Search results for: Yoav Ben-Shahar

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Ben-Shahar</title> <meta name="description" content="Search results for: Yoav Ben-Shahar"> <meta name="keywords" content="Yoav Ben-Shahar"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none 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action="https://publications.waset.org/abstracts/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="Yoav Ben-Shahar"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 1</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: Yoav Ben-Shahar</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Suggested Role for Neutrophil Extracellular Traps Formation in Ewing Sarcoma Immune Microenvironment</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Rachel%20Shukrun">Rachel Shukrun</a>, <a href="https://publications.waset.org/abstracts/search?q=Szilvia%20Baron"> Szilvia Baron</a>, <a href="https://publications.waset.org/abstracts/search?q=Victoria%20Fidel"> Victoria Fidel</a>, <a href="https://publications.waset.org/abstracts/search?q=Anna%20Shusterman"> Anna Shusterman</a>, <a href="https://publications.waset.org/abstracts/search?q=Osnat%20Sher"> Osnat Sher</a>, <a href="https://publications.waset.org/abstracts/search?q=Netanya%20Kollender"> Netanya Kollender</a>, <a href="https://publications.waset.org/abstracts/search?q=Dror%20Levin"> Dror Levin</a>, <a href="https://publications.waset.org/abstracts/search?q=Yair%20Peled"> Yair Peled</a>, <a href="https://publications.waset.org/abstracts/search?q=Yair%20Gortzak"> Yair Gortzak</a>, <a href="https://publications.waset.org/abstracts/search?q=Yoav%20Ben-Shahar"> Yoav Ben-Shahar</a>, <a href="https://publications.waset.org/abstracts/search?q=Revital%20Caspi"> Revital Caspi</a>, <a href="https://publications.waset.org/abstracts/search?q=Sagi%20Gordon"> Sagi Gordon</a>, <a href="https://publications.waset.org/abstracts/search?q=Michal%20Manisterski"> Michal Manisterski</a>, <a href="https://publications.waset.org/abstracts/search?q=Ronit%20Elhasid"> Ronit Elhasid</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Ewing sarcoma (EWS) is a highly aggressive cancer with a survival rate of 70–80% for patients with localized disease and under 30% for those with metastatic disease. Tumor-infiltrating neutrophils (TIN) can generate extracellular net-like DNA structures known as neutrophil extracellular traps (NETs). However, little is known about the presence and prognostic significance of tumor-infiltrating NETs in EWS. Herein, we investigated 46 patients diagnosed with EWS and treated in the Tel Aviv Medical Center between 2010 and 2021. TINs and NETs were identified in diagnostic biopsies of EWS by immunofluorescent. In addition, NETs were investigated in neutrophils isolated from peripheral blood samples of EWS patients at diagnosis and following neoadjuvant chemotherapy. The relationships between the presence of TINs and NETs, pathological and clinical features, and outcomes were analyzed. Our results demonstrate that TIN and NETs at diagnosis were higher in EWS patients with metastatic disease compared to those with local disease. High NETs formation at diagnosis predicted poor response to neo-adjuvant chemotherapy, relapse, and death from disease (P < .05). NETs formation in peripheral blood samples at diagnosis was significantly elevated among patients with EWS compared to pediatric controls and decreased significantly following neoadjuvant chemotherapy. In conclusion, NETs formation seems to have a role in the EWS immune microenvironment. Their presence can refine risk stratification, predict chemotherapy resistance and survival, and serve as a therapeutic target in patients with EWS. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ewing%20sarcoma" title="Ewing sarcoma">Ewing sarcoma</a>, <a href="https://publications.waset.org/abstracts/search?q=tumor%20microenvironment" title=" tumor microenvironment"> tumor microenvironment</a>, <a href="https://publications.waset.org/abstracts/search?q=neutrophil" title=" neutrophil"> neutrophil</a>, <a href="https://publications.waset.org/abstracts/search?q=neutrophil%20extracellular%20traps%20%28NETs%29" title=" neutrophil extracellular traps (NETs)"> neutrophil extracellular traps (NETs)</a>, <a href="https://publications.waset.org/abstracts/search?q=prognosis" title=" prognosis"> prognosis</a> </p> <a href="https://publications.waset.org/abstracts/177507/suggested-role-for-neutrophil-extracellular-traps-formation-in-ewing-sarcoma-immune-microenvironment" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/177507.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">64</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th foundational anniversary</a></li> 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Search results for: Yoav Ben-Shahar