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</ul> </li> <li id="toc-Hereditary_hypotrichosis" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Hereditary_hypotrichosis"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.2</span> <span>Hereditary hypotrichosis</span> </div> </a> <ul id="toc-Hereditary_hypotrichosis-sublist" class="vector-toc-list"> <li id="toc-Mapping" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Mapping"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.2.1</span> <span>Mapping</span> </div> </a> <ul id="toc-Mapping-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Molecular_genetics" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Molecular_genetics"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.2.2</span> <span>Molecular genetics</span> </div> </a> <ul id="toc-Molecular_genetics-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> </ul> </li> <li id="toc-Interactions" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Interactions"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Interactions</span> </div> </a> <ul id="toc-Interactions-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>References</span> </div> </a> <ul id="toc-References-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Further_reading" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Further_reading"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>Further reading</span> </div> </a> <ul id="toc-Further_reading-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Contents" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Toggle the table of contents" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Toggle the table of contents</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">DSC3</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Go to an article in another language. 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data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Appearance</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">move to sidebar</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">hide</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Protein-coding gene in the species Homo sapiens</div> <table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">DSC3</th></tr><tr><td colspan="4" style="text-align:center"></td></tr><tr><th colspan="4" style="text-align:center;background-color:#ddd">Identifiers</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><span class="plainlinks"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/3037">DSC3</a></span>, CDHF3, DSC, DSC1, DSC2, DSC4, HT-CP, desmocollin 3</td></tr><tr><th scope="row" style="background-color:#c3fdb8">External IDs</th><td colspan="3" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/600271">600271</a>; <a href="/wiki/Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:1194993">1194993</a>; <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=1462">1462</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=DSC3">DSC3</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000134762">DSC3 - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_human_chromosome_18.svg" class="mw-file-description" title="Chromosome 18 (human)"><img alt="Chromosome 18 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/f/f2/Ideogram_human_chromosome_18.svg/300px-Ideogram_human_chromosome_18.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/f2/Ideogram_human_chromosome_18.svg/450px-Ideogram_human_chromosome_18.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/f2/Ideogram_human_chromosome_18.svg/600px-Ideogram_human_chromosome_18.svg.png 2x" data-file-width="474" data-file-height="189" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Chromosome_18_(human)" class="mw-redirect" title="Chromosome 18 (human)">Chromosome 18 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Human_chromosome_18_ideogram.svg" class="mw-file-description" title="Chromosome 18 (human)"><img alt="Chromosome 18 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/9/94/Human_chromosome_18_ideogram.svg/300px-Human_chromosome_18_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/94/Human_chromosome_18_ideogram.svg/450px-Human_chromosome_18_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/94/Human_chromosome_18_ideogram.svg/600px-Human_chromosome_18_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 108.10614576956px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for DSC3"><img alt="Genomic location for DSC3" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 114.1px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for DSC3"><img alt="Genomic location for DSC3" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">18q12.1</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">30,989,365 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">31,042,815 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_house_mouse_chromosome_18.svg" class="mw-file-description" title="Chromosome 18 (mouse)"><img alt="Chromosome 18 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/5/5c/Ideogram_house_mouse_chromosome_18.svg/260px-Ideogram_house_mouse_chromosome_18.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/5c/Ideogram_house_mouse_chromosome_18.svg/390px-Ideogram_house_mouse_chromosome_18.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/5c/Ideogram_house_mouse_chromosome_18.svg/520px-Ideogram_house_mouse_chromosome_18.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks">Chromosome 18 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Ideogram_of_house_mouse_chromosome_18.svg" class="mw-file-description" title="Chromosome 18 (mouse)"><img alt="Chromosome 18 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/8/86/Ideogram_of_house_mouse_chromosome_18.svg/300px-Ideogram_of_house_mouse_chromosome_18.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/86/Ideogram_of_house_mouse_chromosome_18.svg/450px-Ideogram_of_house_mouse_chromosome_18.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/86/Ideogram_of_house_mouse_chromosome_18.svg/600px-Ideogram_of_house_mouse_chromosome_18.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 59.82853588314px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for DSC3"><img alt="Genomic location for DSC3" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 65.8px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for DSC3"><img alt="Genomic location for DSC3" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">18 A2|18 11.11 cM</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">20,093,987 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">20,135,408 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Human_genome" title="Human genome">Human</a></b></th><th><b><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000134762">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">skin of thigh</li><br /><li style="line-height: 137%;">gingival epithelium</li><br /><li style="line-height: 137%;">skin of hip</li><br /><li style="line-height: 137%;">vulva</li><br /><li style="line-height: 137%;">human penis</li><br /><li style="line-height: 137%;">hair follicle</li><br /><li style="line-height: 137%;">nipple</li><br /><li style="line-height: 137%;">skin of arm</li><br /><li style="line-height: 137%;">skin of abdomen</li><br /><li style="line-height: 137%;">oral cavity</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000059898">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">epidermis</li><br /><li style="line-height: 137%;">skin of external ear</li><br /><li style="line-height: 137%;">hair follicle</li><br /><li style="line-height: 137%;">skin of back</li><br /><li style="line-height: 137%;">skin of abdomen</li><br /><li style="line-height: 137%;">lip</li><br /><li style="line-height: 137%;">molar</li><br /><li style="line-height: 137%;">mesenteric lymph nodes</li><br /><li style="line-height: 137%;">cornea</li><br /><li style="line-height: 137%;">conjunctival fornix</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000134762">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:PBB_GE_DSC3_206032_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/4/4f/PBB_GE_DSC3_206032_at_fs.png/250px-PBB_GE_DSC3_206032_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/4f/PBB_GE_DSC3_206032_at_fs.png/375px-PBB_GE_DSC3_206032_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/4f/PBB_GE_DSC3_206032_at_fs.png/500px-PBB_GE_DSC3_206032_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span><br /><br /><span typeof="mw:File"><a href="/wiki/File:PBB_GE_DSC3_206033_s_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/3/3e/PBB_GE_DSC3_206033_s_at_fs.png/250px-PBB_GE_DSC3_206033_s_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/3e/PBB_GE_DSC3_206033_s_at_fs.png/375px-PBB_GE_DSC3_206033_s_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/3e/PBB_GE_DSC3_206033_s_at_fs.png/500px-PBB_GE_DSC3_206033_s_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="http://biogps.org/gene/1825/">More reference expression data</a></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Molecular function</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005509">calcium ion binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045295">gamma-catenin binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0046872">metal ion binding</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Cellular component</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005911">cell-cell junction</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016021">integral component of membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030057">desmosome</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016020">membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001533">cornified envelope</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005886">plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030054">cell junction</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005576">extracellular region</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005737">cytoplasm</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Biological process</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007156">homophilic cell adhesion via plasma membrane adhesion molecules</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050821">protein stabilization</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007155">cell adhesion</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031424">keratinization</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0070268">cornification</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001701">in utero embryonic development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0098609">cell-cell adhesion</a></li></ul> </div></td></tr><tr><td colspan="4" style="background-color:#eee;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:#c3fdb8">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=1825&rn=1">1825</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=13507&rn=1">13507</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000134762;db=core">ENSG00000134762</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000059898;db=core">ENSMUSG00000059898</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q14574">Q14574</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P55850">P55850</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (mRNA)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_024423">NM_024423</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001941">NM_001941</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001291809">NM_001291809</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_007882">NM_007882</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (protein)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001932">NP_001932</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_077741">NP_077741</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001278738">NP_001278738</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_031908">NP_031908</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">Location (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr18:30989365-31042815">Chr 18: 30.99 – 31.04 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr18:20093987-20135408">Chr 18: 20.09 – 20.14 Mb</a></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q17914814" class="extiw" title="d:Q17914814">View/Edit Human</a></td><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q18250251" class="extiw" title="d:Q18250251">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table> <p><b>Desmocollin-3</b> is a <a href="/wiki/Protein" title="Protein">protein</a> that in humans is encoded by the <i>DSC3</i> <a href="/wiki/Gene" title="Gene">gene</a>.<sup id="cite_ref-pmid7774948_5-0" class="reference"><a href="#cite_note-pmid7774948-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid8486729_6-0" class="reference"><a href="#cite_note-pmid8486729-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-entrez_7-0" class="reference"><a href="#cite_note-entrez-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Gene">Gene</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=DSC3&action=edit&section=1" title="Edit section: Gene"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms.<sup id="cite_ref-entrez_7-1" class="reference"><a href="#cite_note-entrez-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Function">Function</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=DSC3&action=edit&section=2" title="Edit section: Function"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Desmocollin-3 is a calcium-dependent <a href="/wiki/Glycoprotein" title="Glycoprotein">glycoprotein</a> that is a member of the <a href="/wiki/Desmocollin" title="Desmocollin">desmocollin</a> subfamily of the <a href="/wiki/Cadherin" title="Cadherin">cadherin</a> superfamily. These <a href="/wiki/Desmosome" title="Desmosome">desmosomal</a> family members, along with the <a href="/wiki/Desmoglein" title="Desmoglein">desmogleins</a>, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation.<sup id="cite_ref-entrez_7-2" class="reference"><a href="#cite_note-entrez-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> The loss of these components leads to a lack of adhesion and a gain of cellular mobility.<sup id="cite_ref-pmid16168112_8-0" class="reference"><a href="#cite_note-pmid16168112-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Clinical_significance">Clinical significance</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=DSC3&action=edit&section=3" title="Edit section: Clinical significance"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Breast_cancer">Breast cancer</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=DSC3&action=edit&section=4" title="Edit section: Breast cancer"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Through the process of <a href="/wiki/Epigenetic" class="mw-redirect" title="Epigenetic">epigenetic</a> <a href="/wiki/Gene_silencing" title="Gene silencing">silencing</a>, the expression of the desmocollin-3 protein is down regulated in many <a href="/wiki/Breast_cancer" title="Breast cancer">breast cancers</a>.<sup id="cite_ref-pmid16168112_8-1" class="reference"><a href="#cite_note-pmid16168112-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Hereditary_hypotrichosis">Hereditary hypotrichosis</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=DSC3&action=edit&section=5" title="Edit section: Hereditary hypotrichosis"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>A <a href="/wiki/Consanguinity" title="Consanguinity">consanguineous</a> Afghan family in which 3 sisters, 12 to 18 years of age, and their 5-year-old brother displayed features of hereditary <a href="/wiki/Hypotrichosis" class="mw-redirect" title="Hypotrichosis">hypotrichosis</a>, associated with vesicles on the scalp and skin.<sup id="cite_ref-pmid19765682_9-0" class="reference"><a href="#cite_note-pmid19765682-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> At birth, scalp hair was present, and after ritual shaving at 1 week of age, scalp hair grew back; however, the hair was fragile and began falling out at 2 to 3 months of age, eventually leaving only sparse hair on the scalp. Vesicles that were less than 1 cm in diameter were observed on the scalp and skin of most of the body, occasionally disappearing but then reappearing; intermittently, the vesicles would burst with a release of fluid, leaving scars on the site that took 3 to 4 months to heal. There were no mucosal vesicles. Upon examination, the affected individuals were nearly devoid of eyebrows, eyelashes, axillary hair, and body hair. Teeth, nails, palms, soles, sweating, and hearing were normal, as was electrocardiography. Serum <a href="/wiki/Immunoglobulin_A" title="Immunoglobulin A">IgA</a>, <a href="/wiki/Immunoglobulin_E" title="Immunoglobulin E">IgE</a>, and <a href="/wiki/Immunoglobulin_D" title="Immunoglobulin D">IgD</a> were measured in 1 individual and showed no change compared to controls. The parents were clinically unaffected. A scalp biopsy of the 18-year-old sister showed slight follicular plugging, mild perivascular and periadnexal inflammatory cell presence, and normal hair follicles. The sebaceous glands appeared morphologically normal and connected to the hair follicles.<sup id="cite_ref-pmid19765682_9-1" class="reference"><a href="#cite_note-pmid19765682-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading4"><h4 id="Mapping">Mapping</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=DSC3&action=edit&section=6" title="Edit section: Mapping"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><a href="/wiki/Genotyping" title="Genotyping">Genotyping</a> and <a href="/wiki/Genetic_linkage" title="Genetic linkage">linkage analysis</a> of the consanguineous Afghan family resulted in a maximum 2-point load score of 2.68 (theta = 0.0) at markers D18S36 and D18S547. Multipoint analysis generated a maximum load score of 3.30 at marker D18S877. <a href="/wiki/Genetic_recombination" title="Genetic recombination">Recombination</a> events defined an 8.30-cM critical interval on chromosome 18q12.1, flanked by markers D18S66 and D18S1139, containing 30 genes.<sup id="cite_ref-pmid19765682_9-2" class="reference"><a href="#cite_note-pmid19765682-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading4"><h4 id="Molecular_genetics">Molecular genetics</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=DSC3&action=edit&section=7" title="Edit section: Molecular genetics"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>A nonsense mutation in the DSC3 gene (600271.0001) mapping to chromosome 18q12.1 was identified in the consanguineous Afghan family with hypotrichosis and recurrent skin vesicles (613102). The unaffected parents and 3 healthy siblings were heterozygous for the mutation, which was not found in 100 unrelated ethnically matched controls.<sup id="cite_ref-pmid19765682_9-3" class="reference"><a href="#cite_note-pmid19765682-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> In affected members of this family with hypotrichosis were <a href="/wiki/Zygosity#Homozygous" title="Zygosity">homozygous</a> for a 2129T-G transversion in exon 14 of the DSC3 gene, resulting in a leu710-to-ter (L710X; Ayub et al. 2009) substitution at the junction of the transmembrane and the C-terminal cytoplasmic domain, predicted to cause premature termination and nonsense mediated decay of the mRNA or instability of the truncated protein. The unaffected parents and 3 healthy siblings were heterozygous for the mutation, which was not found in 100 unrelated ethnically matched controls.<sup id="cite_ref-pmid19765682_9-4" class="reference"><a href="#cite_note-pmid19765682-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Interactions">Interactions</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=DSC3&action=edit&section=8" title="Edit section: Interactions"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>DSC3 has been shown to <a href="/wiki/Protein-protein_interaction" class="mw-redirect" title="Protein-protein interaction">interact</a> with <a href="/wiki/PKP3" class="mw-redirect" title="PKP3">PKP3</a>.<sup id="cite_ref-pmid12707304_10-0" class="reference"><a href="#cite_note-pmid12707304-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=DSC3&action=edit&section=9" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-refGRCh38Ensembl-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCh38Ensembl_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000134762">GRCh38: Ensembl release 89: ENSG00000134762</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-refGRCm38Ensembl-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCm38Ensembl_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000059898">GRCm38: Ensembl release 89: ENSMUSG00000059898</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=1825">"Human PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=National+Center+for+Biotechnology+Information%2C+U.S.+National+Library+of+Medicine&rft.atitle=Human+PubMed+Reference%3A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fdb%3Dgene%26cmd%3DLink%26LinkName%3Dgene_pubmed%26from_uid%3D1825&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADSC3" class="Z3988"></span></span> </li> <li id="cite_note-4"><span class="mw-cite-backlink"><b><a href="#cite_ref-4">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=13507">"Mouse PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=National+Center+for+Biotechnology+Information%2C+U.S.+National+Library+of+Medicine&rft.atitle=Mouse+PubMed+Reference%3A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fdb%3Dgene%26cmd%3DLink%26LinkName%3Dgene_pubmed%26from_uid%3D13507&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADSC3" class="Z3988"></span></span> </li> <li id="cite_note-pmid7774948-5"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid7774948_5-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFAmagaiWangMinoshimaKawamura1995" class="citation journal cs1">Amagai M, Wang Y, Minoshima S, Kawamura K, Green KJ, Nishikawa T, Shimizu N (Jul 1995). "Assignment of the human genes for desmocollin 3 (DSC3) and desmocollin 4 (DSC4) to chromosome 18q12". <i>Genomics</i>. <b>25</b> (1): 330–2. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2F0888-7543%2895%2980154-E">10.1016/0888-7543(95)80154-E</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/7774948">7774948</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Genomics&rft.atitle=Assignment+of+the+human+genes+for+desmocollin+3+%28DSC3%29+and+desmocollin+4+%28DSC4%29+to+chromosome+18q12&rft.volume=25&rft.issue=1&rft.pages=330-2&rft.date=1995-07&rft_id=info%3Adoi%2F10.1016%2F0888-7543%2895%2980154-E&rft_id=info%3Apmid%2F7774948&rft.aulast=Amagai&rft.aufirst=M&rft.au=Wang%2C+Y&rft.au=Minoshima%2C+S&rft.au=Kawamura%2C+K&rft.au=Green%2C+KJ&rft.au=Nishikawa%2C+T&rft.au=Shimizu%2C+N&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADSC3" class="Z3988"></span></span> </li> <li id="cite_note-pmid8486729-6"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid8486729_6-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBuxtonCowinFrankeGarrod1993" class="citation journal cs1">Buxton RS, Cowin P, Franke WW, Garrod DR, Green KJ, King IA, Koch PJ, Magee AI, Rees DA, Stanley JR, et al. (Jun 1993). <a rel="nofollow" class="external text" href="http://spiral.imperial.ac.uk/bitstream/10044/1/21146/2/Nomenclature%20of%20the%20desmosomal%20cadherins..pdf">"Nomenclature of the desmosomal cadherins"</a> <span class="cs1-format">(PDF)</span>. <i>J Cell Biol</i>. <b>121</b> (3): 481–3. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1083%2Fjcb.121.3.481">10.1083/jcb.121.3.481</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2119574">2119574</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/8486729">8486729</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J+Cell+Biol&rft.atitle=Nomenclature+of+the+desmosomal+cadherins&rft.volume=121&rft.issue=3&rft.pages=481-3&rft.date=1993-06&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2119574%23id-name%3DPMC&rft_id=info%3Apmid%2F8486729&rft_id=info%3Adoi%2F10.1083%2Fjcb.121.3.481&rft.aulast=Buxton&rft.aufirst=RS&rft.au=Cowin%2C+P&rft.au=Franke%2C+WW&rft.au=Garrod%2C+DR&rft.au=Green%2C+KJ&rft.au=King%2C+IA&rft.au=Koch%2C+PJ&rft.au=Magee%2C+AI&rft.au=Rees%2C+DA&rft.au=Stanley%2C+JR&rft_id=http%3A%2F%2Fspiral.imperial.ac.uk%2Fbitstream%2F10044%2F1%2F21146%2F2%2FNomenclature%2520of%2520the%2520desmosomal%2520cadherins..pdf&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADSC3" class="Z3988"></span></span> </li> <li id="cite_note-entrez-7"><span class="mw-cite-backlink">^ <a href="#cite_ref-entrez_7-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-entrez_7-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-entrez_7-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1825">"Entrez Gene: DSC3 desmocollin 3"</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Entrez+Gene%3A+DSC3+desmocollin+3&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3FDb%3Dgene%26Cmd%3DShowDetailView%26TermToSearch%3D1825&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADSC3" class="Z3988"></span></span> </li> <li id="cite_note-pmid16168112-8"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid16168112_8-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid16168112_8-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFOshiroKimWozniakJunk2005" class="citation journal cs1">Oshiro MM, Kim CJ, Wozniak RJ, Junk DJ, Muñoz-Rodríguez JL, Burr JA, Fitzgerald M, Pawar SC, Cress AE, Domann FE, Futscher BW (2005). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1242132">"Epigenetic silencing of DSC3 is a common event in human breast cancer"</a>. <i>Breast Cancer Res</i>. <b>7</b> (5): R669–80. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1186%2Fbcr1273">10.1186/bcr1273</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1242132">1242132</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16168112">16168112</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Breast+Cancer+Res.&rft.atitle=Epigenetic+silencing+of+DSC3+is+a+common+event+in+human+breast+cancer&rft.volume=7&rft.issue=5&rft.pages=R669-80&rft.date=2005&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1242132%23id-name%3DPMC&rft_id=info%3Apmid%2F16168112&rft_id=info%3Adoi%2F10.1186%2Fbcr1273&rft.aulast=Oshiro&rft.aufirst=MM&rft.au=Kim%2C+CJ&rft.au=Wozniak%2C+RJ&rft.au=Junk%2C+DJ&rft.au=Mu%C3%B1oz-Rodr%C3%ADguez%2C+JL&rft.au=Burr%2C+JA&rft.au=Fitzgerald%2C+M&rft.au=Pawar%2C+SC&rft.au=Cress%2C+AE&rft.au=Domann%2C+FE&rft.au=Futscher%2C+BW&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1242132&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADSC3" class="Z3988"></span></span> </li> <li id="cite_note-pmid19765682-9"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid19765682_9-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid19765682_9-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-pmid19765682_9-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-pmid19765682_9-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-pmid19765682_9-4"><sup><i><b>e</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFAyubBasitJelaniUr_Rehman2009" class="citation journal cs1">Ayub M, Basit S, Jelani M, Ur Rehman F, Iqbal M, Yasinzai M, Ahmad W (October 2009). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756559">"A Homozygous Nonsense Mutation in the Human Desmocollin-3 (DSC3) Gene Underlies Hereditary Hypotrichosis and Recurrent Skin Vesicles"</a>. <i>Am. J. Hum. Genet</i>. <b>85</b> (4): 515–20. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.ajhg.2009.08.015">10.1016/j.ajhg.2009.08.015</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756559">2756559</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/19765682">19765682</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Am.+J.+Hum.+Genet.&rft.atitle=A+Homozygous+Nonsense+Mutation+in+the+Human+Desmocollin-3+%28DSC3%29+Gene+Underlies+Hereditary+Hypotrichosis+and+Recurrent+Skin+Vesicles&rft.volume=85&rft.issue=4&rft.pages=515-20&rft.date=2009-10&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2756559%23id-name%3DPMC&rft_id=info%3Apmid%2F19765682&rft_id=info%3Adoi%2F10.1016%2Fj.ajhg.2009.08.015&rft.aulast=Ayub&rft.aufirst=M&rft.au=Basit%2C+S&rft.au=Jelani%2C+M&rft.au=Ur+Rehman%2C+F&rft.au=Iqbal%2C+M&rft.au=Yasinzai%2C+M&rft.au=Ahmad%2C+W&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2756559&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADSC3" class="Z3988"></span></span> </li> <li id="cite_note-pmid12707304-10"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid12707304_10-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBonnéGilbertHatzfeldChen2003" class="citation journal cs1">Bonné S, Gilbert B, Hatzfeld M, Chen X, Green KJ, van Roy F (April 2003). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172904">"Defining desmosomal plakophilin-3 interactions"</a>. <i>J. Cell Biol</i>. <b>161</b> (2): 403–16. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1083%2Fjcb.200303036">10.1083/jcb.200303036</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172904">2172904</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12707304">12707304</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J.+Cell+Biol.&rft.atitle=Defining+desmosomal+plakophilin-3+interactions&rft.volume=161&rft.issue=2&rft.pages=403-16&rft.date=2003-04&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2172904%23id-name%3DPMC&rft_id=info%3Apmid%2F12707304&rft_id=info%3Adoi%2F10.1083%2Fjcb.200303036&rft.aulast=Bonn%C3%A9&rft.aufirst=S&rft.au=Gilbert%2C+B&rft.au=Hatzfeld%2C+M&rft.au=Chen%2C+X&rft.au=Green%2C+KJ&rft.au=van+Roy%2C+F&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2172904&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADSC3" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=DSC3&action=edit&section=10" title="Edit section: Further reading"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin refbegin-columns references-column-width" style="column-width: 30em"> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFArnemannSpurrWheeler1991" class="citation journal cs1">Arnemann J, Spurr NK, Wheeler GN, et al. (1991). "Chromosomal assignment of the human genes coding for the major proteins of the desmosome junction, desmoglein DGI (DSG), desmocollins DGII/III (DSC), desmoplakins DPI/II (DSP), and plakoglobin DPIII (JUP)". <i>Genomics</i>. <b>10</b> (3): 640–5. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2F0888-7543%2891%2990446-L">10.1016/0888-7543(91)90446-L</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/1889810">1889810</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Genomics&rft.atitle=Chromosomal+assignment+of+the+human+genes+coding+for+the+major+proteins+of+the+desmosome+junction%2C+desmoglein+DGI+%28DSG%29%2C+desmocollins+DGII%2FIII+%28DSC%29%2C+desmoplakins+DPI%2FII+%28DSP%29%2C+and+plakoglobin+DPIII+%28JUP%29&rft.volume=10&rft.issue=3&rft.pages=640-5&rft.date=1991&rft_id=info%3Adoi%2F10.1016%2F0888-7543%2891%2990446-L&rft_id=info%3Apmid%2F1889810&rft.aulast=Arnemann&rft.aufirst=J&rft.au=Spurr%2C+NK&rft.au=Wheeler%2C+GN&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADSC3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKingSullivanBennettBuxton1995" class="citation journal cs1">King IA, Sullivan KH, Bennett R, Buxton RS (1995). <a rel="nofollow" class="external text" href="https://doi.org/10.1111%2F1523-1747.ep12319935">"The desmocollins of human foreskin epidermis: identification and chromosomal assignment of a third gene and expression patterns of the three isoforms"</a>. <i>J. Invest. Dermatol</i>. <b>105</b> (3): 314–21. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1111%2F1523-1747.ep12319935">10.1111/1523-1747.ep12319935</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/7665906">7665906</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J.+Invest.+Dermatol.&rft.atitle=The+desmocollins+of+human+foreskin+epidermis%3A+identification+and+chromosomal+assignment+of+a+third+gene+and+expression+patterns+of+the+three+isoforms&rft.volume=105&rft.issue=3&rft.pages=314-21&rft.date=1995&rft_id=info%3Adoi%2F10.1111%2F1523-1747.ep12319935&rft_id=info%3Apmid%2F7665906&rft.aulast=King&rft.aufirst=IA&rft.au=Sullivan%2C+KH&rft.au=Bennett%2C+R&rft.au=Buxton%2C+RS&rft_id=https%3A%2F%2Fdoi.org%2F10.1111%252F1523-1747.ep12319935&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADSC3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKawamuraWatanabeSuzuki1994" class="citation journal cs1">Kawamura K, Watanabe K, Suzuki T, et al. (1994). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0021-9258%2818%2947193-1">"cDNA cloning and expression of a novel human desmocollin"</a>. <i>J. Biol. Chem</i>. <b>269</b> (42): 26295–302. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0021-9258%2818%2947193-1">10.1016/S0021-9258(18)47193-1</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/7929347">7929347</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J.+Biol.+Chem.&rft.atitle=cDNA+cloning+and+expression+of+a+novel+human+desmocollin&rft.volume=269&rft.issue=42&rft.pages=26295-302&rft.date=1994&rft_id=info%3Adoi%2F10.1016%2FS0021-9258%2818%2947193-1&rft_id=info%3Apmid%2F7929347&rft.aulast=Kawamura&rft.aufirst=K&rft.au=Watanabe%2C+K&rft.au=Suzuki%2C+T&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252FS0021-9258%252818%252947193-1&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADSC3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBuxtonWheelerPidsley1994" class="citation journal cs1">Buxton RS, Wheeler GN, Pidsley SC, et al. (1994). "Mouse desmocollin (Dsc3) and desmoglein (Dsg1) genes are closely linked in the proximal region of chromosome 18". <i>Genomics</i>. <b>21</b> (3): 510–6. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1006%2Fgeno.1994.1309">10.1006/geno.1994.1309</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/7959727">7959727</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Genomics&rft.atitle=Mouse+desmocollin+%28Dsc3%29+and+desmoglein+%28Dsg1%29+genes+are+closely+linked+in+the+proximal+region+of+chromosome+18&rft.volume=21&rft.issue=3&rft.pages=510-6&rft.date=1994&rft_id=info%3Adoi%2F10.1006%2Fgeno.1994.1309&rft_id=info%3Apmid%2F7959727&rft.aulast=Buxton&rft.aufirst=RS&rft.au=Wheeler%2C+GN&rft.au=Pidsley%2C+SC&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADSC3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFNuberSchäferStehr1997" class="citation journal cs1">Nuber UA, Schäfer S, Stehr S, et al. (1997). "Patterns of desmocollin synthesis in human epithelia: immunolocalization of desmocollins 1 and 3 in special epithelia and in cultured cells". <i>Eur. J. Cell Biol</i>. <b>71</b> (1): 1–13. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/8884173">8884173</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Eur.+J.+Cell+Biol.&rft.atitle=Patterns+of+desmocollin+synthesis+in+human+epithelia%3A+immunolocalization+of+desmocollins+1+and+3+in+special+epithelia+and+in+cultured+cells&rft.volume=71&rft.issue=1&rft.pages=1-13&rft.date=1997&rft_id=info%3Apmid%2F8884173&rft.aulast=Nuber&rft.aufirst=UA&rft.au=Sch%C3%A4fer%2C+S&rft.au=Stehr%2C+S&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADSC3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKurzenMollMoll1998" class="citation journal cs1">Kurzen H, Moll I, Moll R, et al. (1998). "Compositionally different desmosomes in the various compartments of the human hair follicle". <i>Differentiation</i>. <b>63</b> (5): 295–304. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1046%2Fj.1432-0436.1998.6350295.x">10.1046/j.1432-0436.1998.6350295.x</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9810708">9810708</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Differentiation&rft.atitle=Compositionally+different+desmosomes+in+the+various+compartments+of+the+human+hair+follicle&rft.volume=63&rft.issue=5&rft.pages=295-304&rft.date=1998&rft_id=info%3Adoi%2F10.1046%2Fj.1432-0436.1998.6350295.x&rft_id=info%3Apmid%2F9810708&rft.aulast=Kurzen&rft.aufirst=H&rft.au=Moll%2C+I&rft.au=Moll%2C+R&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADSC3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMollHoudekSchäfer1999" class="citation journal cs1">Moll I, Houdek P, Schäfer S, et al. (1999). "Diversity of desmosomal proteins in regenerating epidermis: immunohistochemical study using a human skin organ culture model". <i>Arch. Dermatol. Res</i>. <b>291</b> (7–8): 437–46. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2Fs004030050435">10.1007/s004030050435</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10482015">10482015</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:6183331">6183331</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Arch.+Dermatol.+Res.&rft.atitle=Diversity+of+desmosomal+proteins+in+regenerating+epidermis%3A+immunohistochemical+study+using+a+human+skin+organ+culture+model&rft.volume=291&rft.issue=7%E2%80%938&rft.pages=437-46&rft.date=1999&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A6183331%23id-name%3DS2CID&rft_id=info%3Apmid%2F10482015&rft_id=info%3Adoi%2F10.1007%2Fs004030050435&rft.aulast=Moll&rft.aufirst=I&rft.au=Houdek%2C+P&rft.au=Sch%C3%A4fer%2C+S&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADSC3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFHanakawaAmagaiShirakata2000" class="citation journal cs1">Hanakawa Y, Amagai M, Shirakata Y, et al. (2000). <a rel="nofollow" class="external text" href="https://doi.org/10.1242%2Fjcs.113.10.1803">"Different effects of dominant negative mutants of desmocollin and desmoglein on the cell-cell adhesion of keratinocytes"</a>. <i>J. Cell Sci</i>. <b>113</b> (10): 1803–11. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1242%2Fjcs.113.10.1803">10.1242/jcs.113.10.1803</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10769211">10769211</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J.+Cell+Sci.&rft.atitle=Different+effects+of+dominant+negative+mutants+of+desmocollin+and+desmoglein+on+the+cell-cell+adhesion+of+keratinocytes&rft.volume=113&rft.issue=10&rft.pages=1803-11&rft.date=2000&rft_id=info%3Adoi%2F10.1242%2Fjcs.113.10.1803&rft_id=info%3Apmid%2F10769211&rft.aulast=Hanakawa&rft.aufirst=Y&rft.au=Amagai%2C+M&rft.au=Shirakata%2C+Y&rft_id=https%3A%2F%2Fdoi.org%2F10.1242%252Fjcs.113.10.1803&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADSC3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWhittockHuntRickman2000" class="citation journal cs1">Whittock NV, Hunt DM, Rickman L, et al. (2000). "Genomic organization and amplification of the human desmosomal cadherin genes DSC1 and DSC3, encoding desmocollin types 1 and 3". <i>Biochem. Biophys. Res. Commun</i>. <b>276</b> (2): 454–60. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1006%2Fbbrc.2000.3500">10.1006/bbrc.2000.3500</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11027496">11027496</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Biochem.+Biophys.+Res.+Commun.&rft.atitle=Genomic+organization+and+amplification+of+the+human+desmosomal+cadherin+genes+DSC1+and+DSC3%2C+encoding+desmocollin+types+1+and+3&rft.volume=276&rft.issue=2&rft.pages=454-60&rft.date=2000&rft_id=info%3Adoi%2F10.1006%2Fbbrc.2000.3500&rft_id=info%3Apmid%2F11027496&rft.aulast=Whittock&rft.aufirst=NV&rft.au=Hunt%2C+DM&rft.au=Rickman%2C+L&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADSC3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFGadhaviGreenwoodStrom2001" class="citation journal cs1">Gadhavi PL, Greenwood MD, Strom M, et al. (2001). "The regulatory region of the human desmocollin 3 promoter forms a DNA four-way junction". <i>Biochem. Biophys. Res. Commun</i>. <b>281</b> (2): 520–8. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1006%2Fbbrc.2001.4375">10.1006/bbrc.2001.4375</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11181078">11181078</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Biochem.+Biophys.+Res.+Commun.&rft.atitle=The+regulatory+region+of+the+human+desmocollin+3+promoter+forms+a+DNA+four-way+junction&rft.volume=281&rft.issue=2&rft.pages=520-8&rft.date=2001&rft_id=info%3Adoi%2F10.1006%2Fbbrc.2001.4375&rft_id=info%3Apmid%2F11181078&rft.aulast=Gadhavi&rft.aufirst=PL&rft.au=Greenwood%2C+MD&rft.au=Strom%2C+M&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADSC3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKlusRokaeusBittner2001" class="citation journal cs1">Klus GT, Rokaeus N, Bittner ML, et al. (2001). "Down-regulation of the desmosomal cadherin desmocollin 3 in human breast cancer". <i>Int. J. Oncol</i>. <b>19</b> (1): 169–74. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.3892%2Fijo.19.1.169">10.3892/ijo.19.1.169</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11408939">11408939</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Int.+J.+Oncol.&rft.atitle=Down-regulation+of+the+desmosomal+cadherin+desmocollin+3+in+human+breast+cancer&rft.volume=19&rft.issue=1&rft.pages=169-74&rft.date=2001&rft_id=info%3Adoi%2F10.3892%2Fijo.19.1.169&rft_id=info%3Apmid%2F11408939&rft.aulast=Klus&rft.aufirst=GT&rft.au=Rokaeus%2C+N&rft.au=Bittner%2C+ML&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADSC3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWeiskeSchönebergSchröder2001" class="citation journal cs1">Weiske J, Schöneberg T, Schröder W, et al. (2001). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M105769200">"The fate of desmosomal proteins in apoptotic cells"</a>. <i>J. Biol. Chem</i>. <b>276</b> (44): 41175–81. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M105769200">10.1074/jbc.M105769200</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11500511">11500511</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J.+Biol.+Chem.&rft.atitle=The+fate+of+desmosomal+proteins+in+apoptotic+cells&rft.volume=276&rft.issue=44&rft.pages=41175-81&rft.date=2001&rft_id=info%3Adoi%2F10.1074%2Fjbc.M105769200&rft_id=info%3Apmid%2F11500511&rft.aulast=Weiske&rft.aufirst=J&rft.au=Sch%C3%B6neberg%2C+T&rft.au=Schr%C3%B6der%2C+W&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.M105769200&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADSC3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFHatzfeldGreenSauter2003" class="citation journal cs1">Hatzfeld M, Green KJ, Sauter H (2003). <a rel="nofollow" class="external text" href="https://doi.org/10.1242%2Fjcs.00275">"Targeting of p0071 to desmosomes and adherens junctions is mediated by different protein domains"</a>. <i>J. Cell Sci</i>. <b>116</b> (Pt 7): 1219–33. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1242%2Fjcs.00275">10.1242/jcs.00275</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12615965">12615965</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J.+Cell+Sci.&rft.atitle=Targeting+of+p0071+to+desmosomes+and+adherens+junctions+is+mediated+by+different+protein+domains&rft.volume=116&rft.issue=Pt+7&rft.pages=1219-33&rft.date=2003&rft_id=info%3Adoi%2F10.1242%2Fjcs.00275&rft_id=info%3Apmid%2F12615965&rft.aulast=Hatzfeld&rft.aufirst=M&rft.au=Green%2C+KJ&rft.au=Sauter%2C+H&rft_id=https%3A%2F%2Fdoi.org%2F10.1242%252Fjcs.00275&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADSC3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBonnéGilbertHatzfeld2003" class="citation journal cs1">Bonné S, Gilbert B, Hatzfeld M, et al. (2003). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172904">"Defining desmosomal plakophilin-3 interactions"</a>. <i>J. Cell Biol</i>. <b>161</b> (2): 403–16. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1083%2Fjcb.200303036">10.1083/jcb.200303036</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172904">2172904</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12707304">12707304</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J.+Cell+Biol.&rft.atitle=Defining+desmosomal+plakophilin-3+interactions&rft.volume=161&rft.issue=2&rft.pages=403-16&rft.date=2003&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2172904%23id-name%3DPMC&rft_id=info%3Apmid%2F12707304&rft_id=info%3Adoi%2F10.1083%2Fjcb.200303036&rft.aulast=Bonn%C3%A9&rft.aufirst=S&rft.au=Gilbert%2C+B&rft.au=Hatzfeld%2C+M&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2172904&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADSC3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFOshiroWattsWozniak2003" class="citation journal cs1">Oshiro MM, Watts GS, Wozniak RJ, et al. (2003). "Mutant p53 and aberrant cytosine methylation cooperate to silence gene expression". <i>Oncogene</i>. <b>22</b> (23): 3624–34. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fsj.onc.1206545">10.1038/sj.onc.1206545</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12789271">12789271</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:9578959">9578959</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=Mutant+p53+and+aberrant+cytosine+methylation+cooperate+to+silence+gene+expression&rft.volume=22&rft.issue=23&rft.pages=3624-34&rft.date=2003&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A9578959%23id-name%3DS2CID&rft_id=info%3Apmid%2F12789271&rft_id=info%3Adoi%2F10.1038%2Fsj.onc.1206545&rft.aulast=Oshiro&rft.aufirst=MM&rft.au=Watts%2C+GS&rft.au=Wozniak%2C+RJ&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADSC3" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFZhangWolf-YadlinRoss2005" class="citation journal cs1">Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fmcp.M500089-MCP200">"Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules"</a>. <i>Mol. Cell. Proteomics</i>. <b>4</b> (9): 1240–50. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fmcp.M500089-MCP200">10.1074/mcp.M500089-MCP200</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15951569">15951569</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Mol.+Cell.+Proteomics&rft.atitle=Time-resolved+mass+spectrometry+of+tyrosine+phosphorylation+sites+in+the+epidermal+growth+factor+receptor+signaling+network+reveals+dynamic+modules&rft.volume=4&rft.issue=9&rft.pages=1240-50&rft.date=2005&rft_id=info%3Adoi%2F10.1074%2Fmcp.M500089-MCP200&rft_id=info%3Apmid%2F15951569&rft.aulast=Zhang&rft.aufirst=Y&rft.au=Wolf-Yadlin%2C+A&rft.au=Ross%2C+PL&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fmcp.M500089-MCP200&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADSC3" class="Z3988"></span></li></ul> </div> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline 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ul{display:inline-block;white-space:nowrap;line-height:inherit}.mw-parser-output .navbar-brackets::before{margin-right:-0.125em;content:"[ "}.mw-parser-output .navbar-brackets::after{margin-left:-0.125em;content:" ]"}.mw-parser-output .navbar li{word-spacing:-0.125em}.mw-parser-output .navbar a>span,.mw-parser-output .navbar a>abbr{text-decoration:inherit}.mw-parser-output .navbar-mini abbr{font-variant:small-caps;border-bottom:none;text-decoration:none;cursor:inherit}.mw-parser-output .navbar-ct-full{font-size:114%;margin:0 7em}.mw-parser-output .navbar-ct-mini{font-size:114%;margin:0 4em}html.skin-theme-clientpref-night .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}@media(prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}}@media print{.mw-parser-output .navbar{display:none!important}}</style><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Cell_adhesion_molecules" title="Template:Cell adhesion molecules"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Cell_adhesion_molecules" title="Template talk:Cell adhesion molecules"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Cell_adhesion_molecules" title="Special:EditPage/Template:Cell adhesion molecules"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Membrane_proteins:_cell_adhesion_molecules" style="font-size:114%;margin:0 4em"><a href="/wiki/Membrane_protein" title="Membrane protein">Membrane proteins</a>: <a href="/wiki/Cell_adhesion_molecule" title="Cell adhesion molecule">cell adhesion molecules</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Cell_adhesion_molecule#Calcium-independent" title="Cell adhesion molecule">Calcium-independent</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/IgSF_CAM" title="IgSF CAM">IgSF CAM</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Neural_cell_adhesion_molecule" title="Neural cell adhesion molecule">N-CAM</a> (<a href="/wiki/Myelin_protein_zero" title="Myelin protein zero">Myelin protein zero</a>)</li> <li><a href="/wiki/Intercellular_adhesion_molecule" title="Intercellular adhesion molecule">ICAM</a> (<a href="/wiki/ICAM-1" title="ICAM-1">1</a>, <a href="/wiki/ICAM5" title="ICAM5">5</a>)</li> <li><a href="/wiki/VCAM-1" title="VCAM-1">VCAM-1</a></li> <li><a href="/wiki/CD31" title="CD31">PE-CAM</a></li> <li><a href="/wiki/L1_family" title="L1 family">L1 family</a> <ul><li><a href="/wiki/L1_(protein)" title="L1 (protein)">L1-CAM</a></li> <li><a href="/wiki/NRCAM" title="NRCAM">NRCAM</a></li> <li><a href="/wiki/NFASC" title="NFASC">NFASC</a></li> <li><a href="/wiki/CHL1" title="CHL1">CHL1</a></li></ul></li> <li><a href="/wiki/Nectin" title="Nectin">Nectin</a> <ul><li><a href="/wiki/PVRL1" class="mw-redirect" title="PVRL1">PVRL1</a></li> <li><a href="/wiki/PVRL2" class="mw-redirect" title="PVRL2">PVRL2</a></li> <li><a href="/wiki/PVRL3" class="mw-redirect" title="PVRL3">PVRL3</a></li> <li><a href="/wiki/CADM1" class="mw-redirect" title="CADM1">CADM1</a></li> <li><a href="/wiki/CADM3" title="CADM3">CADM3</a></li> <li><a href="/wiki/CD155" title="CD155">CD155</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Integrin" title="Integrin">Integrins</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Lymphocyte_function-associated_antigen_1" title="Lymphocyte function-associated antigen 1">LFA-1</a> (<a href="/wiki/CD11a" class="mw-redirect" title="CD11a">CD11a</a>+<a href="/wiki/CD18" class="mw-redirect" title="CD18">CD18</a>)</li> <li><a href="/wiki/Integrin_alphaXbeta2" title="Integrin alphaXbeta2">Integrin alphaXbeta2</a> (<a href="/wiki/CD11c" class="mw-redirect" title="CD11c">CD11c</a>+<a href="/wiki/CD18" class="mw-redirect" title="CD18">CD18</a>)</li> <li><a href="/wiki/Macrophage-1_antigen" title="Macrophage-1 antigen">Macrophage-1 antigen</a> (<a href="/wiki/CD11b" class="mw-redirect" title="CD11b">CD11b</a>+<a href="/wiki/CD18" class="mw-redirect" title="CD18">CD18</a>)</li> <li><a href="/wiki/VLA-4" title="VLA-4">VLA-4</a> (<a href="/wiki/CD49d" class="mw-redirect" title="CD49d">CD49d</a>+<a href="/wiki/CD29" class="mw-redirect" title="CD29">CD29</a>)</li> <li><a href="/wiki/Glycoprotein_IIb/IIIa" title="Glycoprotein IIb/IIIa">Glycoprotein IIb/IIIa</a> (<a href="/wiki/ITGA2B" class="mw-redirect" title="ITGA2B">ITGA2B</a>+<a href="/wiki/ITGB3" class="mw-redirect" title="ITGB3">ITGB3</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Cell_adhesion_molecule#Calcium-dependent" title="Cell adhesion molecule">Calcium-dependent</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Cadherin" title="Cadherin">Cadherins</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Classical</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CDH1_(gene)" class="mw-redirect" title="CDH1 (gene)">CDH1</a></li> <li><a href="/wiki/CDH2" class="mw-redirect" title="CDH2">CDH2</a></li> <li><a href="/wiki/CDH3_(gene)" title="CDH3 (gene)">CDH3</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Desmosome" title="Desmosome">Desmosomal</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Desmoglein" title="Desmoglein">Desmoglein</a> (<a href="/wiki/Desmoglein-1" title="Desmoglein-1">DSG1</a>, <a href="/wiki/Desmoglein-2" title="Desmoglein-2">DSG2</a>, <a href="/wiki/Desmoglein-3" title="Desmoglein-3">DSG3</a>, <a href="/wiki/Desmoglein-4" title="Desmoglein-4">DSG4</a>)</li> <li><a href="/wiki/Desmocollin" title="Desmocollin">Desmocollin</a> (<a href="/wiki/DSC1" title="DSC1">DSC1</a>, <a href="/wiki/DSC2" title="DSC2">DSC2</a>, <a class="mw-selflink selflink">DSC3</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Protocadherin" title="Protocadherin">Protocadherin</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/PCDH1" title="PCDH1">PCDH1</a></li> <li><a href="/wiki/PCDH15" title="PCDH15">PCDH15</a></li> <li><a href="/wiki/Protocadherin_19" title="Protocadherin 19">PCDH19</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Unconventional/ungrouped</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/T-cadherin" title="T-cadherin">T-cadherin</a></li> <li><a href="/wiki/CDH4" title="CDH4">CDH4</a></li> <li><a href="/wiki/VE-cadherin" title="VE-cadherin">CDH5</a></li> <li><a href="/wiki/CDH6" title="CDH6">CDH6</a></li> <li><a href="/wiki/CDH8" title="CDH8">CDH8</a></li> <li><a href="/wiki/CDH11" title="CDH11">CDH11</a></li> <li><a href="/wiki/CDH12" title="CDH12">CDH12</a></li> <li><a href="/wiki/CDH15" title="CDH15">CDH15</a></li> <li><a href="/wiki/CDH16" title="CDH16">CDH16</a></li> <li><a href="/wiki/CDH17" title="CDH17">CDH17</a></li> <li><a href="/wiki/CDH9" title="CDH9">CDH9</a></li> <li><a href="/wiki/CDH10" title="CDH10">CDH10</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Selectin" title="Selectin">Selectins</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/E-selectin" title="E-selectin">E-selectin</a></li> <li><a href="/wiki/L-selectin" title="L-selectin">L-selectin</a></li> <li><a href="/wiki/P-selectin" title="P-selectin">P-selectin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Lymphocyte_homing_receptor" title="Lymphocyte homing receptor">Lymphocyte homing receptor</a>: <a href="/wiki/CD44" title="CD44">CD44</a></li> <li><a href="/wiki/L-selectin" title="L-selectin">L-selectin</a></li> <li><i><a href="/wiki/Integrin" title="Integrin">integrin</a></i> (<a href="/wiki/VLA-4" title="VLA-4">VLA-4</a>, <a href="/wiki/LFA-1" class="mw-redirect" title="LFA-1">LFA-1</a>)</li></ul> <ul><li><a href="/wiki/Carcinoembryonic_antigen" title="Carcinoembryonic antigen">Carcinoembryonic antigen</a></li> <li><a href="/wiki/CD24" title="CD24">CD24</a></li> <li><a href="/wiki/CD44" title="CD44">CD44</a></li> <li><a href="/wiki/CD146" title="CD146">CD146</a></li> <li><a href="/wiki/Epithelial_cell_adhesion_molecule" title="Epithelial cell adhesion molecule">EpCAM</a></li></ul> </div></td></tr></tbody></table></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Retrieved from "<a dir="ltr" href="https://en.wikipedia.org/w/index.php?title=DSC3&oldid=1188051035">https://en.wikipedia.org/w/index.php?title=DSC3&oldid=1188051035</a>"</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Help:Category" title="Help:Category">Category</a>: <ul><li><a href="/wiki/Category:Genes_on_human_chromosome_18" title="Category:Genes on human chromosome 18">Genes on human chromosome 18</a></li></ul></div><div id="mw-hidden-catlinks" class="mw-hidden-catlinks mw-hidden-cats-hidden">Hidden categories: <ul><li><a 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