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Nowe spojrzenie na mechanizmy pamięci |

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left: 50%; margin-left: -90px; overflow: hidden; } .flashing{ font-weight: 500; -webkit-animation: bgcolorchange 2s infinite; /* Chrome, Safari, Opera */ animation: 2s infinite bgcolorchange; } @keyframes bgcolorchange { 50% { text-decoration: underline; } 51% { text-decoration: none; } } @-webkit-keyframes bgcolorchange { 0% {text-decoration: underline;} 100% {text-decoration: none;} } #secondary-menu .sub-menu > .menu-item > a{ line-height: 1.3; padding: 10px; } .sub-menu > .menu-item { text-align: center; background: #eee; border: 1px solid #bbb; border-bottom-color: rgb(187, 187, 187); border-bottom-style: solid; border-bottom-width: 1px; border-bottom: 0; } .sub-menu > .menu-item:first-child { position: relative; margin-top: 10px; border-radius: 2px 2px 0 0; } #secondary-menu .menu-item:hover>.sub-menu{ display: block; } .sub-menu > .menu-item > a { display: block; line-height: 3; font-weight: 500; font-size: 0.9em; } .sub-menu > .menu-item > a:hover { font-weight: 700; text-decoration: none; } .sub-menu > .menu-item:hover{ background: #dedede; cursor: pointer; } .sub-menu > .menu-item { text-align: center; background: #eee; border: 1px solid #bbb; border-bottom: 0; } .smalldwn{ text-align: right; float: right; margin-right: 220px; } .icmbanner h2{ font-family: 'Bebas Neue', sans-serif; letter-spacing: 2px !important; font-size: 45px; text-align: center; } .icmbanner .col-md-12>*{ padding-left: 0px; } .icmbanner .links .col-md-1{ margin-left: 40px; margin-right: 20px; } .icmbanner .links{ margin-top: 15px; text-align: center; } .icmbanner .links a{ font-family: "Source Sans Pro", sans-serif; text-transform: uppercase; letter-spacing: 1px; font-size: 17px; padding: 15px 30px; font-weight: 3 00; border-radius: 0px; border: 1px solid white; display: inline; } .icmbanner .links a:hover { opacity: 1; text-decoration: none; } .icmbanner .links a:focus{ text-decoration: none; } .icmbanner li h5{ margin-left: 7px; font-family: "Source Sans Pro", sans-serif; font-size: 14px; font-weight: 300; margin-bottom: 20px; letter-spacing: 2px; } .icmbanner .col-md-12>h2{ margin-top: 0px; margin-bottom: 0; } .icmbanner .col-md-12>h4{ margin-top: 0px; margin-bottom: 60px; font-family: "Source Sans Pro", sans-serif; letter-spacing: 1px; text-align: center; font-weight: 300; font-size: 19px; } .smalldwn .download .pdf-button { width: 150px; margin: auto; background: #4182a2; color: white; padding: 0.4rem; font-size: 18px; font-weight: 700; } .nextseminar.gray-background { border-radius: 5px !important; margin-bottom: 20px;padding: 15px !important; font-family: "Fira Sans Extra Condensed",Impact,sans-serif; margin-top: 25px; margin-left: 15px; } .seminartable{ margin: auto; } .seminartable tr{ border-top: 1px solid rgb(0,0,0,0.3); } .seminartable tr:last-child{ border-bottom: 1px solid rgb(0,0,0,0.3); } .seminartable tr:first-child td{ padding: 10px 0; } .seminartable tr td{ padding: 0px 0; } .seminartable tr a{ text-decoration: underline } .seminartable tr td{ vertical-align: baseline; } .seminartable tr p, .seminartable tr span{ margin-bottom: 0; line-height: 1em } .iframeresponsive iframe{ width: 100%; height: 350px; margin-top: 15px; } .iframeresponsive.col-md-6 iframe{ height: 200px; margin-bottom: 15px; } .slick-dots{ bottom: 23px; z-index: 999; } .slick-dots li button:before{ color: white; font-size: 9px !important; } .slick-dots li.slick-active button:before { color: white; } .slick-dots li{ line-height: 1.7rem; } .slick-dots li a{ color: white; } .slick-dots li.slick-active a{ color: #ff7f00; } .orange{ color: #ff7f00 } .main-banner .slick-slide>.container>.row>.col-md-12{ height: 427.8px; display: flex; flex-direction: column; justify-content: center; } .main-banner .slick-slide{ height: 427.8px; } .nextseminar img{ max-width: 150px !important; } .post-widgets .nextseminar{ margin-left:0;} .gray-background { background: #263238; color: white; padding: 30px 0; } .nextseminar > h2 { color: #ff7f00; } .nextseminar h2 { font-size: 23px !important; margin: 0; font-family: "Fira Sans Extra Condensed",Impact,sans-serif; } .nextseminar h2 span { font-weight: 500 !important; color: white; } .nextseminar ul{ font-size: 14px; } .nextseminar .gray span { font-size: 18px; } .gray-background h3 { margin: 5px 0 0 0 !important; margin-bottom: 0px; font-size: 18px !important; font-weight: 400; text-transform: none; padding: 0 !important; font-family: "Fira Sans Extra Condensed",Impact,sans-serif; } .nextseminar h3 { margin-bottom: 5px !important; } .nextseminar .btn-primary{ background-image: -webkit-linear-gradient(top,#ffa000 0,#c27a00 100%); background-image: -o-linear-gradient(top,#ffa000 0,#c27a00 100%); background-image: -webkit-gradient(linear,left top,left bottom,from(#ffa000),to(#c27a00)); background-image: linear-gradient(to bottom,#ffa000 0,#c27a00 100%); filter: progid:DXImageTransform.Microsoft.gradient(startColorstr='#ffffa000', endColorstr='#ffc27a00', GradientType=0); filter: progid:DXImageTransform.Microsoft.gradient(enabled=false); background-repeat: repeat-x; border-color: #b87300; padding: 5px; margin-top: 15px; margin-bottom: 0; } .nextseminar p{ margin-bottom:0; } .gray-background .title, .nextseminar .title { font-size: 16px !important; line-height: 1em; } .underline{ text-decoration: underline; } .menu-secondary-container{ position: relative; top: 20px; right: 9px; } .navbar{ min-height: 80px; } .sub-nav > li > a, .sub-nav > li{ background: none !important; color: #555; } .menu-item-5221>a{ color: #999 !important } .menu-item-4910 a{ color: #ff7f00 !important; } .scfe2020-redirections .rpwe-title{ display: none} .iobanner a{ color: white; padding: 8px 0; display: block; } .iobanner{ font-weight: 100; } .iobanner p a{ padding: 0; } .iobanner a img{ margin-right: 7px; display: inline-block !important; } .iobanner .leftbaner{ text-align:right;padding: 6.34em 6em 5em 0; max-height: 391.583px; } .iobanner .rightbaner{ padding: 00em 0em 0em 9em; } 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img[src*='https://icm.edu.pl/wp-content/uploads/2021/03/logo_ICM_nazwa_EN_biale.png'],.downloadpdf img[src*='https://icm.edu.pl/wp-content/uploads/2021/03/logo_ICM_biale.png'],.downloadpdf img[src*='https://icm.edu.pl/wp-content/uploads/2021/03/logo_ICM_nazwa_PL_biale.png']{ background: #333 } .videoSidebar p{ color: #000; } .downloadpdf, .videoSidebar p, .videoSidebar a { font-size: 0.85em; } .downloadpdf a{ color: #000 !important } .videosidebar p { font-size: 0.85em; } .downloadpdf div{ margin-top: 10px; } .downloadpdf a{ color: black; text-align: left; } .single-post-slider{ margin-top: 3rem; } .post-widgets .iframereponsive{ height: 188px; } .youtubescfe{ position: relative; text-align: right; border-bottom: 1px solid #eee; padding-bottom: 1.5rem; } .youtubescfe p{ text-align: left; } .youtubescfe .banner-button{ width: 81px; font-size: 12px; text-align: center; position: relative; color: white !important; background: #ff7f00; padding: 0.5rem 1.8rem; border-radius: 2px; box-shadow: 2px 1px 7px rgba(0,0,0,0.3); transform: scale(1); transition: 0.2s; margin-top: 1rem; } .iframereponsive{ max-width: 100%; width: 100%; margin-top: 3rem; } #news-column{ clear: both; } .scfe2020-redirections .rpwe-clearfix{ display: none; } .scfe2020-redirections .rpwe-clearfix:first-child{ display: block; } .single-post-nav-slider img{ padding: 0.5rem 0.25rem; } #shailan-countdown-2_1{ background: #4182a2; color: white; margin: 10px 0; border-radius: 3px; font-weight: 300; } #page-widget-menu:nth-child(2){ margin-top: 2rem; text-align: center; text-transform: uppercase; font-size: 10px; border: 1px solid #4182a2; padding: 1rem; } .text-table{ border: none; } .text-table tr:first-child{ background: #4182a2 !important; border-bottom: 0; } .text-table tr, .text-table td{ height: auto !important; border: none; } .text-table td{ border-bottom: 1px solid #ddd; padding: 0.5rem 0 } .banners #news-column .content{ margin-top: 0; padding-top: 0; } .main-banner .item{ position: relative; } .main-banner .carousel-caption{ background: rgba(0,0,0,0); padding-top: 3rem; } .banner-button{ color: white !important; background: #ff7f00; padding: 0.5rem 1rem; border-radius: 2px; box-shadow: 2px 1px 7px rgba(0,0,0,0.3); transform: scale(1); transition: 0.2s; top: -10px; position: absolute; margin-left: 0; } @media screen and (max-width: 1024px){ .navSliderWT{ display: none; } .mainSliderWT .slick-dots{ bottom: -10px; } .mainSliderWT .slick-dots li button::before{ color: black !important } } @media screen and (max-width: 1200px){ .banner-button{ font-size: 12px; margin-left: 0; } .main-banner .carousel-caption{ padding-top: 2rem; } .logo img{ max-height: 50px; } #navbar{ padding-left: 0; } } @media screen and (max-width: 991px){ .banner-button{ font-size: 9px; margin-left: -9px; } .main-banner .carousel-caption{ padding-top: 1rem; } } .movies{ margin: 30px 0 0 0; } .inMediaMainPage .row{ border-bottom: 1px solid #ccc; margin-bottom: 5px; margin-left:0; margin-right: 0; 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M. Nenckiego oraz ICM UW, pt. &#8220;<a rel="noreferrer noopener" href="https://doi.org/10.1038/s41380-024-02738-8" target="_blank">Spatio-temporal mechanisms of consolidation, recall and reconsolidation in reward-related memory trace</a>&#8220;. Naukowcy odkryli, jak mózg organizuje i utrwala wspomnienia związane z nagrodą. Uzyskane wyniki mają praktyczne znaczenie dla badań nad uzależnieniami.</h4> <p>Naukowcy odkryli, jak mózg organizuje i utrwala wspomnienia związane z nagrodą. Badania na szczurach wykazały, że podczas procesu tzw. <strong>konsolidacji</strong> aktywność konkretnych grup neuronów staje się bardziej wyspecjalizowana, co stanowi mechanizm dojrzewania pamięci.</p> <p>W eksperymencie zwizualizowano i zmierzono niezależnie aktywację genów związanych z uczeniem w <strong>ponad 2 milionach neuronów</strong> w <strong>14 strukturach mózgu</strong>, na podstawie zbioru <strong>prawie 8 TB zdjęć mikroskopowych</strong>; w analizie zaś zastosowano zaawansowane metody obliczeniowe i uczenie maszynowe.</p> <div style="height:20px" aria-hidden="true" class="wp-block-spacer"></div> <div class="wp-block-image"> <figure class="aligncenter size-full is-resized"><a href="https://icm.edu.pl/wp-content/uploads/2024/09/reward-memory-img.png" data-lbwps-width="717" data-lbwps-height="709"><img decoding="async" loading="lazy" src="https://icm.edu.pl/wp-content/uploads/2024/09/reward-memory-img.png" alt="" class="wp-image-12559" width="377" height="373" srcset="https://icm.edu.pl/wp-content/uploads/2024/09/reward-memory-img.png 717w, https://icm.edu.pl/wp-content/uploads/2024/09/reward-memory-img-300x297.png 300w, https://icm.edu.pl/wp-content/uploads/2024/09/reward-memory-img-45x45.png 45w" sizes="(max-width: 377px) 100vw, 377px" /></a><figcaption class="wp-element-caption"><em>Kolorowe kropki pokazują miejsca aktywacji dwóch ważnych genów pamięci. Każda komórka nerwowa ma ich po dwie kopie, po jednej od każdego z rodziców. Niektóre neurony aktywują oba geny; to na nich skupiła się uwaga autorów.</em></figcaption></figure></div> <div style="height:20px" aria-hidden="true" class="wp-block-spacer"></div> <p>Wyniki pozwoliły uchwycić dojrzewanie pamięci, w szczególności proces przenoszenia informacji do coraz to mniejszych, ale wyspecjalizowanych populacji neuronów.</p> <p>Pokazano także, że wspomnienia związane z podążaniem za przyjemnością są budowane dzięki współpracy struktur odpowiedzialnych zarówno za pamięć przestrzenną i nawigację, jak i za stany emocjonalne. Poznawszy dokładną lokalizację tych wspomnień, można je modyfikować, a nawet wygaszać z użyciem celowanych interwencji łączących manipulacje genetyczne i farmakologiczne.</p> <p>Dane zebrane z całej populacji pokazały, że ekspresja pamięci w zachowaniu jest&nbsp; w dużym stopniu zależna od indywidualnych cech i zmienności. Innymi słowy, każdy z nas zapamiętuje przyjemne wydarzenia nieco inaczej: dla niektórych ważniejsze są emocje, dla innych fakty i detale. Ukazanie tego zróżnicowania dowodzi, że to właśnie badania molekularne pozwalają na skuteczną analizę mechanizmów pamięci, co daje im przewagę jakościową nad eksperymentami czysto behawioralnymi i farmakologicznymi.</p> <p><strong>Uzyskane wyniki mają praktyczne znaczenie dla badań nad uzależnieniami</strong>, czyli stanami, w których wspomnienie przyjemnej nagrody i chęć dążenia do niej przybierają formę patologiczną. Ukazują także ogromną skalę neuroróżnorodności w populacjach biologicznych.</p> <div class="wp-block-uagb-separator uagb-block-c569d5ae"><div class="wp-block-uagb-separator__inner" style="--my-background-image:"></div></div> <h4>Autorzy</h4> <ul> <li><strong>Adam Hamed</strong>, Instytut Biologii Doświadczalnej im. Marcelego Nenckiego, Polska Akademia Nauk</li> <li><strong>Miron Bartosz Kursa</strong>, Interdyscyplinarne Centrum Modelowania Matematycznego i Komputerowego, Uniwersytet Warszawski</li> <li><strong>Wiktoria Mrozek</strong>, Instytut Biologii Doświadczalnej im. Marcelego Nenckiego, Polska Akademia Nauk</li> <li><strong>Krzysztof Piotr Piwoński</strong>, Interdyscyplinarne Centrum Modelowania Matematycznego i Komputerowego, Uniwersytet Warszawski</li> <li><strong>Monika Falińska</strong>, Instytut Biologii Doświadczalnej im. Marcelego Nenckiego, Polska Akademia Nauk</li> <li><strong>Konrad Danielewski</strong>, Instytut Biologii Doświadczalnej im. Marcelego Nenckiego, Polska Akademia Nauk</li> <li><strong>Emilia Rejmak</strong>, Instytut Biologii Doświadczalnej im. Marcelego Nenckiego, Polska Akademia Nauk</li> <li><strong>Urszula Włodkowska</strong>, Instytut Biologii Doświadczalnej im. Marcelego Nenckiego, Polska Akademia Nauk</li> <li><strong>Stepan Kubik</strong>, Instytut Fizjologii, Akademia Nauk Republiki Czeskiej</li> <li><strong>Rafał Czajkowski</strong>, Instytut Biologii Doświadczalnej im. Marcelego Nenckiego, Polska Akademia Nauk</li> </ul> <div class="wp-block-uagb-separator uagb-block-6a771d16"><div class="wp-block-uagb-separator__inner" style="--my-background-image:"></div></div> <p>Link do artykułu: <a rel="noreferrer noopener" href="https://doi.org/10.1038/s41380-024-02738-8" target="_blank">https://doi.org/10.1038/s41380-024-02738-8</a></p> </article> <div class="single-post-slider"> </div> <div class="single-post-nav-slider"> </div> </div><!-- /#post- --> <div class="col-sm-4 col-md-3 col-lg-4 post-widgets"> <!-- <div class="nextseminar gray-background"> <img style="margin-bottom: 10px;" src="https://supercomputingfrontiers.eu/2020/wp-content/uploads/sites/15/2020/06/sfce2020-2.png" class="img-responsive" /> <div class="row"> <div class="col-md-12"> <h2 class="gray"><span style="font-weight: 300">AUG – SEPT, 2020</span></h2> <div class="row"> <div class="col-md-12"> <h3>Tutorials & Workshops</h3> <div class="title"><ul class="affilation" style="padding-left: 15px;width: 100%;list-style: circle !important;"> <li>SOL – Transparent Neural Network Acceleration (NEC)</li> <li>Urica XC – AI environment and graph methods (Cray)</li> <li>Trovares – Graph analytics on enterprise systems</li> </ul></div> <a target="_blank" href="https://supercomputingfrontiers.eu/2020/seminars/" class="btn btn-primary btn-lg" role="button" style="margin-top: 10px;display: block;font-size: 15px;text-transform: uppercase;width: 100%;">Details soon</a> </div> </div> </div> </div> </div> --> <div class="widget" id="news-column"><style>.rpwe-block ul{ list-style: none !important; margin-left: 0 !important; padding-left: 0 !important; } .rpwe-block li{ border-bottom: 1px solid #eee; margin-bottom: 10px; padding-bottom: 10px; list-style-type: none; } .rpwe-block a{ display: inline !important; text-decoration: none; } .post-widgets .rpwe-block a.rpwe-img { display: none !important; } .rpwe-block h3{ background: none !important; clear: none; margin-bottom: 0 !important; margin-top: 0 !important; font-weight: 400; line-height: 1.4em; } .rpwe-block h3 a { color: #333; } .rpwe-thumb{ border: 1px solid #eee !important; box-shadow: none !important; margin: 2px 10px 2px 0; padding: 3px !important; } .rpwe-summary{ font-size: 12px; } .rpwe-time{ color: #319494; font-size: 10px; font-weight: 700; } .rpwe-comment{ color: #bbb; font-size: 11px; padding-left: 5px; } .rpwe-alignleft{ display: inline; float: left; } .rpwe-alignright{ display: inline; float: right; } .rpwe-aligncenter{ display: block; margin-left: auto; margin-right: auto; } .rpwe-clearfix:before, .rpwe-clearfix:after{ content: &quot;&quot;; display: table !important; } .rpwe-clearfix:after{ clear: both; } .rpwe-clearfix{ zoom: 1; } </style><h2>Aktualności</h2><div class="content"><div class="rpwe-block"><ul class="rpwe-ul"><li class="rpwe-li rpwe-clearfix"><a class="rpwe-img" href="https://icm.edu.pl/blog/2024/11/12/icm-uw-realizuje-zadanie-w-ramach-rzadowego-programu-strategicznego-hydrostrateg/" target="_self"><img class="rpwe-alignleft rpwe-thumb" src="https://icm.edu.pl/wp-content/uploads/2024/11/Hydrostrateg-NCBR-165x110.png" alt="ICM UW realizuje zadanie w ramach Rządowego Programu Strategicznego Hydrostrateg" height="110" width="165" loading="lazy" decoding="async"></a><h3 class="rpwe-title"><a href="https://icm.edu.pl/blog/2024/11/12/icm-uw-realizuje-zadanie-w-ramach-rzadowego-programu-strategicznego-hydrostrateg/" target="_self">ICM UW realizuje zadanie w ramach Rządowego Programu Strategicznego Hydrostrateg</a></h3><time class="rpwe-time published" datetime="2024-11-12T09:59:21+01:00">12 listopada 2024</time><div class="rpwe-summary">ICM otrzymał finasowanie ze środków krajowych Narodowego Centrum Badań i Rozwoju na projekt pn. „System Optymalizacji Bieżącej Eksploatacji Kanalizacyjnych sieci ogólnospławnych oraz deszczowych dla zjawisk ekstremalnych (SOBEK)”.</div></li><li class="rpwe-li rpwe-clearfix"><a class="rpwe-img" href="https://icm.edu.pl/blog/2024/10/23/dr-hab-dominik-batorski-w-radzie-polskiego-instytutu-ekonomicznego/" target="_self"><img class="rpwe-alignleft rpwe-thumb" src="https://icm.edu.pl/wp-content/uploads/2024/10/Radia-PIE-165x110.png" alt="Dr hab. 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