Drug Target Review – Issue 3 2022

<!DOCTYPE html> <html lang="en"> <head>  <script src="https://www.googleoptimize.com/optimize.js?id=OPT-NTHPPD3"></script>  <meta charset="utf-8"/><link rel="preconnect" href="https://fonts.gstatic.com/" crossorigin /><script>WebFontConfig={google:{families:["Titillium Web:300,400,600","Muli:300,300i,400,400i,600"]}};if ( typeof WebFont === "object" && typeof WebFont.load === "function" ) { WebFont.load( WebFontConfig ); }</script><script data-optimized="1" src="https://www.drugtargetreview.com/wp-content/plugins/litespeed-cache/assets/js/webfontloader.min.js"></script> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <link href="/favicon.ico?v=2" type="image/x-icon" rel="shortcut icon" /> <title>Drug Target Review – Issue 3 2022</title> <meta name="viewport" content="width=device-width, minimum-scale=1.0, maximum-scale=1.0" />  <link rel="preconnect" href="https://fonts.gstatic.com" crossorigin /> <link rel="preload" as="style" href="https://fonts.googleapis.com/css?family=Titillium+Web:300,400,600&display=swap" /> <link rel="preload" as="style" href="https://fonts.googleapis.com/css?family=Muli:300,300i,400,400i,600&display=swap" /> <script src="https://kit.fontawesome.com/c03cee598b.js" crossorigin="anonymous"></script> <link href="https://www.drugtargetreview.com/wp-content/themes/dtr19/style.css?1707434961" rel="stylesheet" type="text/css"> <link href="https://www.drugtargetreview.com/wp-content/themes/dtr19/style-zform.css?174" rel="stylesheet" type="text/css">  <link href="https://www.drugtargetreview.com/wp-content/themes/dtr19/responsive.css?72" rel="stylesheet" type="text/css"> <link href="https://www.drugtargetreview.com/wp-content/themes/dtr19/style-grid.css?66" rel="stylesheet" type="text/css" id="grid">  <script type="text/javascript" src="https://www.drugtargetreview.com/wp-content/themes/dtr19/js/term_more5.js"></script> <script type = "text/javascript" src = "https://www.drugtargetreview.com/wp-content/themes/dtr19/js/wallpaper8.js"></script> <script type = "text/javascript"> window.onscroll = myFunction; //calling myFunction each time we scroll </script> <meta name='robots' content='index, follow, max-image-preview:large, max-snippet:-1, max-video-preview:-1' /> <meta property="og:locale" content="en_GB" /> <meta property="og:type" content="article" /> <meta property="og:title" content="Drug Target Review – Issue 3 2022" /> <meta property="og:description" content="In this issue are articles on engineered bacteria, how smFRET was used to image GPCRs and an assay to identify COVID-19 drugs." /> <meta property="og:url" content="https://www.drugtargetreview.com/article/104912/drug-target-review-issue-3-2022/" /> <meta property="og:site_name" content="Drug Target Review" /> <meta property="og:image" content="https://www.drugtargetreview.com/wp-content/uploads/DTR-Issue-3-Feature-750-x-500.jpg" /> <meta property="og:image:secure_url" content="https://www.drugtargetreview.com/wp-content/uploads/DTR-Issue-3-Feature-750-x-500.jpg" />  <meta name="description" content="In this issue are articles on engineered bacteria, how smFRET was used to image GPCRs and an assay to identify COVID-19 drugs." /> <link rel="canonical" href="https://www.drugtargetreview.com/article/104912/drug-target-review-issue-3-2022/" /> <meta property="og:locale" content="en_GB" /> <meta property="og:type" content="article" /> <meta property="og:title" content="Drug Target Review – Issue 3 2022" /> <meta property="og:description" content="In this issue are articles on engineered bacteria, how smFRET was used to image GPCRs and an assay to identify COVID-19 drugs." /> <meta property="og:url" content="https://www.drugtargetreview.com/article/104912/drug-target-review-issue-3-2022/" /> <meta property="og:site_name" content="Drug Target Review" /> <meta property="article:publisher" content="https://www.facebook.com/DrugTargetReview" /> <meta property="article:modified_time" content="2022-12-06T11:24:40+00:00" /> <meta property="og:image" content="https://www.drugtargetreview.com/wp-content/uploads/DTR-Issue-3-Feature-750-x-500.jpg" /> <meta property="og:image:width" content="750" /> <meta property="og:image:height" content="500" /> <meta property="og:image:type" content="image/jpeg" /> <meta name="twitter:label1" content="Estimated reading time" /> <meta name="twitter:data1" content="1 minute" /> <script type="application/ld+json" class="yoast-schema-graph">{"@context":"https://schema.org","@graph":[{"@type":"WebPage","@id":"https://www.drugtargetreview.com/article/104912/drug-target-review-issue-3-2022/","url":"https://www.drugtargetreview.com/article/104912/drug-target-review-issue-3-2022/","name":"Drug Target Review – Issue 3 2022","isPartOf":{"@id":"https://www.drugtargetreview.com/#website"},"primaryImageOfPage":{"@id":"https://www.drugtargetreview.com/article/104912/drug-target-review-issue-3-2022/#primaryimage"},"image":{"@id":"https://www.drugtargetreview.com/article/104912/drug-target-review-issue-3-2022/#primaryimage"},"thumbnailUrl":"https://www.drugtargetreview.com/wp-content/uploads/DTR-Issue-3-Feature-750-x-500.jpg","datePublished":"2022-09-14T10:29:57+00:00","dateModified":"2022-12-06T11:24:40+00:00","description":"In this issue are articles on engineered bacteria, how smFRET was used to image GPCRs and an assay to identify COVID-19 drugs.","breadcrumb":{"@id":"https://www.drugtargetreview.com/article/104912/drug-target-review-issue-3-2022/#breadcrumb"},"inLanguage":"en-GB","potentialAction":[{"@type":"ReadAction","target":["https://www.drugtargetreview.com/article/104912/drug-target-review-issue-3-2022/"]}]},{"@type":"ImageObject","inLanguage":"en-GB","@id":"https://www.drugtargetreview.com/article/104912/drug-target-review-issue-3-2022/#primaryimage","url":"https://www.drugtargetreview.com/wp-content/uploads/DTR-Issue-3-Feature-750-x-500.jpg","contentUrl":"https://www.drugtargetreview.com/wp-content/uploads/DTR-Issue-3-Feature-750-x-500.jpg","width":750,"height":500,"caption":"DTR Issue 3 Feature 750 x 500"},{"@type":"BreadcrumbList","@id":"https://www.drugtargetreview.com/article/104912/drug-target-review-issue-3-2022/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://www.drugtargetreview.com/"},{"@type":"ListItem","position":2,"name":"Articles","item":"https://www.drugtargetreview.com/article/"},{"@type":"ListItem","position":3,"name":"Drug Target Review – Issue 3 2022"}]},{"@type":"WebSite","@id":"https://www.drugtargetreview.com/#website","url":"https://www.drugtargetreview.com/","name":"Drug Target Review","description":"The leading drug discovery website","publisher":{"@id":"https://www.drugtargetreview.com/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https://www.drugtargetreview.com/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-GB"},{"@type":"Organization","@id":"https://www.drugtargetreview.com/#organization","name":"Drug Target Review","url":"https://www.drugtargetreview.com/","logo":{"@type":"ImageObject","inLanguage":"en-GB","@id":"https://www.drugtargetreview.com/#/schema/logo/image/","url":"https://www.drugtargetreview.com/wp-content/uploads/dtr-logo-large.png","contentUrl":"https://www.drugtargetreview.com/wp-content/uploads/dtr-logo-large.png","width":408,"height":212,"caption":"Drug Target Review"},"image":{"@id":"https://www.drugtargetreview.com/#/schema/logo/image/"},"sameAs":["https://www.facebook.com/DrugTargetReview","https://x.com/DrugTargetRev","https://www.linkedin.com/company/european-drug-target-review"]}]}</script>  <link rel='dns-prefetch' href='//js.stripe.com' /> <link rel='dns-prefetch' href='//cdn.jsdelivr.net' /> <link rel='dns-prefetch' href='//use.fontawesome.com' /> <script type="text/javascript"> /* <![CDATA[ */ window._wpemojiSettings = {"baseUrl":"https:\/\/s.w.org\/images\/core\/emoji\/15.0.3\/72x72\/","ext":".png","svgUrl":"https:\/\/s.w.org\/images\/core\/emoji\/15.0.3\/svg\/","svgExt":".svg","source":{"concatemoji":"https:\/\/www.drugtargetreview.com\/wp-includes\/js\/wp-emoji-release.min.js?ver=62f62f3de500b9c925887338eccd4afd"}}; /*! This file is auto-generated */ !function(i,n){var o,s,e;function c(e){try{var t={supportTests:e,timestamp:(new Date).valueOf()};sessionStorage.setItem(o,JSON.stringify(t))}catch(e){}}function p(e,t,n){e.clearRect(0,0,e.canvas.width,e.canvas.height),e.fillText(t,0,0);var t=new Uint32Array(e.getImageData(0,0,e.canvas.width,e.canvas.height).data),r=(e.clearRect(0,0,e.canvas.width,e.canvas.height),e.fillText(n,0,0),new Uint32Array(e.getImageData(0,0,e.canvas.width,e.canvas.height).data));return t.every(function(e,t){return e===r[t]})}function u(e,t,n){switch(t){case"flag":return n(e,"\ud83c\udff3\ufe0f\u200d\u26a7\ufe0f","\ud83c\udff3\ufe0f\u200b\u26a7\ufe0f")?!1:!n(e,"\ud83c\uddfa\ud83c\uddf3","\ud83c\uddfa\u200b\ud83c\uddf3")&&!n(e,"\ud83c\udff4\udb40\udc67\udb40\udc62\udb40\udc65\udb40\udc6e\udb40\udc67\udb40\udc7f","\ud83c\udff4\u200b\udb40\udc67\u200b\udb40\udc62\u200b\udb40\udc65\u200b\udb40\udc6e\u200b\udb40\udc67\u200b\udb40\udc7f");case"emoji":return!n(e,"\ud83d\udc26\u200d\u2b1b","\ud83d\udc26\u200b\u2b1b")}return!1}function f(e,t,n){var r="undefined"!=typeof WorkerGlobalScope&&self instanceof WorkerGlobalScope?new OffscreenCanvas(300,150):i.createElement("canvas"),a=r.getContext("2d",{willReadFrequently:!0}),o=(a.textBaseline="top",a.font="600 32px Arial",{});return e.forEach(function(e){o[e]=t(a,e,n)}),o}function t(e){var t=i.createElement("script");t.src=e,t.defer=!0,i.head.appendChild(t)}"undefined"!=typeof Promise&&(o="wpEmojiSettingsSupports",s=["flag","emoji"],n.supports={everything:!0,everythingExceptFlag:!0},e=new Promise(function(e){i.addEventListener("DOMContentLoaded",e,{once:!0})}),new Promise(function(t){var n=function(){try{var e=JSON.parse(sessionStorage.getItem(o));if("object"==typeof e&&"number"==typeof e.timestamp&&(new Date).valueOf()<e.timestamp+604800&&"object"==typeof e.supportTests)return e.supportTests}catch(e){}return null}();if(!n){if("undefined"!=typeof Worker&&"undefined"!=typeof OffscreenCanvas&&"undefined"!=typeof URL&&URL.createObjectURL&&"undefined"!=typeof Blob)try{var e="postMessage("+f.toString()+"("+[JSON.stringify(s),u.toString(),p.toString()].join(",")+"));",r=new Blob([e],{type:"text/javascript"}),a=new Worker(URL.createObjectURL(r),{name:"wpTestEmojiSupports"});return void(a.onmessage=function(e){c(n=e.data),a.terminate(),t(n)})}catch(e){}c(n=f(s,u,p))}t(n)}).then(function(e){for(var t in e)n.supports[t]=e[t],n.supports.everything=n.supports.everything&&n.supports[t],"flag"!==t&&(n.supports.everythingExceptFlag=n.supports.everythingExceptFlag&&n.supports[t]);n.supports.everythingExceptFlag=n.supports.everythingExceptFlag&&!n.supports.flag,n.DOMReady=!1,n.readyCallback=function(){n.DOMReady=!0}}).then(function(){return e}).then(function(){var e;n.supports.everything||(n.readyCallback(),(e=n.source||{}).concatemoji?t(e.concatemoji):e.wpemoji&&e.twemoji&&(t(e.twemoji),t(e.wpemoji)))}))}((window,document),window._wpemojiSettings); /* ]]> */ </script> <script id="drugt-ready"> window.advanced_ads_ready=function(e,a){a=a||"complete";var d=function(e){return"interactive"===a?"loading"!==e:"complete"===e};d(document.readyState)?e():document.addEventListener("readystatechange",(function(a){d(a.target.readyState)&&e()}),{once:"interactive"===a})},window.advanced_ads_ready_queue=window.advanced_ads_ready_queue||[]; </script> <link rel='stylesheet' id='font-awesome-free-css' href='//use.fontawesome.com/releases/v5.6.1/css/all.css?ver=62f62f3de500b9c925887338eccd4afd' type='text/css' media='all' /> <style id='wp-emoji-styles-inline-css' type='text/css'> img.wp-smiley, img.emoji { display: inline !important; border: none !important; box-shadow: none !important; height: 1em !important; width: 1em !important; margin: 0 0.07em !important; vertical-align: -0.1em !important; background: none !important; padding: 0 !important; } </style> <link rel='stylesheet' id='wp-block-library-css' href='https://www.drugtargetreview.com/wp-includes/css/dist/block-library/style.min.css?ver=62f62f3de500b9c925887338eccd4afd' type='text/css' media='all' /> <style id='powerpress-player-block-style-inline-css' type='text/css'> </style> <style id='classic-theme-styles-inline-css' type='text/css'> /*! This file is auto-generated */ .wp-block-button__link{color:#fff;background-color:#32373c;border-radius:9999px;box-shadow:none;text-decoration:none;padding:calc(.667em + 2px) calc(1.333em + 2px);font-size:1.125em}.wp-block-file__button{background:#32373c;color:#fff;text-decoration:none} </style> <style id='global-styles-inline-css' type='text/css'> :root{--wp--preset--aspect-ratio--square: 1;--wp--preset--aspect-ratio--4-3: 4/3;--wp--preset--aspect-ratio--3-4: 3/4;--wp--preset--aspect-ratio--3-2: 3/2;--wp--preset--aspect-ratio--2-3: 2/3;--wp--preset--aspect-ratio--16-9: 16/9;--wp--preset--aspect-ratio--9-16: 9/16;--wp--preset--color--black: #000000;--wp--preset--color--cyan-bluish-gray: #abb8c3;--wp--preset--color--white: #ffffff;--wp--preset--color--pale-pink: #f78da7;--wp--preset--color--vivid-red: #cf2e2e;--wp--preset--color--luminous-vivid-orange: #ff6900;--wp--preset--color--luminous-vivid-amber: #fcb900;--wp--preset--color--light-green-cyan: #7bdcb5;--wp--preset--color--vivid-green-cyan: #00d084;--wp--preset--color--pale-cyan-blue: #8ed1fc;--wp--preset--color--vivid-cyan-blue: #0693e3;--wp--preset--color--vivid-purple: #9b51e0;--wp--preset--gradient--vivid-cyan-blue-to-vivid-purple: linear-gradient(135deg,rgba(6,147,227,1) 0%,rgb(155,81,224) 100%);--wp--preset--gradient--light-green-cyan-to-vivid-green-cyan: linear-gradient(135deg,rgb(122,220,180) 0%,rgb(0,208,130) 100%);--wp--preset--gradient--luminous-vivid-amber-to-luminous-vivid-orange: linear-gradient(135deg,rgba(252,185,0,1) 0%,rgba(255,105,0,1) 100%);--wp--preset--gradient--luminous-vivid-orange-to-vivid-red: linear-gradient(135deg,rgba(255,105,0,1) 0%,rgb(207,46,46) 100%);--wp--preset--gradient--very-light-gray-to-cyan-bluish-gray: linear-gradient(135deg,rgb(238,238,238) 0%,rgb(169,184,195) 100%);--wp--preset--gradient--cool-to-warm-spectrum: linear-gradient(135deg,rgb(74,234,220) 0%,rgb(151,120,209) 20%,rgb(207,42,186) 40%,rgb(238,44,130) 60%,rgb(251,105,98) 80%,rgb(254,248,76) 100%);--wp--preset--gradient--blush-light-purple: linear-gradient(135deg,rgb(255,206,236) 0%,rgb(152,150,240) 100%);--wp--preset--gradient--blush-bordeaux: linear-gradient(135deg,rgb(254,205,165) 0%,rgb(254,45,45) 50%,rgb(107,0,62) 100%);--wp--preset--gradient--luminous-dusk: linear-gradient(135deg,rgb(255,203,112) 0%,rgb(199,81,192) 50%,rgb(65,88,208) 100%);--wp--preset--gradient--pale-ocean: linear-gradient(135deg,rgb(255,245,203) 0%,rgb(182,227,212) 50%,rgb(51,167,181) 100%);--wp--preset--gradient--electric-grass: linear-gradient(135deg,rgb(202,248,128) 0%,rgb(113,206,126) 100%);--wp--preset--gradient--midnight: linear-gradient(135deg,rgb(2,3,129) 0%,rgb(40,116,252) 100%);--wp--preset--font-size--small: 13px;--wp--preset--font-size--medium: 20px;--wp--preset--font-size--large: 36px;--wp--preset--font-size--x-large: 42px;--wp--preset--spacing--20: 0.44rem;--wp--preset--spacing--30: 0.67rem;--wp--preset--spacing--40: 1rem;--wp--preset--spacing--50: 1.5rem;--wp--preset--spacing--60: 2.25rem;--wp--preset--spacing--70: 3.38rem;--wp--preset--spacing--80: 5.06rem;--wp--preset--shadow--natural: 6px 6px 9px rgba(0, 0, 0, 0.2);--wp--preset--shadow--deep: 12px 12px 50px rgba(0, 0, 0, 0.4);--wp--preset--shadow--sharp: 6px 6px 0px rgba(0, 0, 0, 0.2);--wp--preset--shadow--outlined: 6px 6px 0px -3px rgba(255, 255, 255, 1), 6px 6px rgba(0, 0, 0, 1);--wp--preset--shadow--crisp: 6px 6px 0px rgba(0, 0, 0, 1);}:where(.is-layout-flex){gap: 0.5em;}:where(.is-layout-grid){gap: 0.5em;}body .is-layout-flex{display: flex;}.is-layout-flex{flex-wrap: wrap;align-items: center;}.is-layout-flex > :is(*, div){margin: 0;}body .is-layout-grid{display: grid;}.is-layout-grid > :is(*, div){margin: 0;}:where(.wp-block-columns.is-layout-flex){gap: 2em;}:where(.wp-block-columns.is-layout-grid){gap: 2em;}:where(.wp-block-post-template.is-layout-flex){gap: 1.25em;}:where(.wp-block-post-template.is-layout-grid){gap: 1.25em;}.has-black-color{color: var(--wp--preset--color--black) !important;}.has-cyan-bluish-gray-color{color: var(--wp--preset--color--cyan-bluish-gray) !important;}.has-white-color{color: var(--wp--preset--color--white) !important;}.has-pale-pink-color{color: var(--wp--preset--color--pale-pink) !important;}.has-vivid-red-color{color: var(--wp--preset--color--vivid-red) !important;}.has-luminous-vivid-orange-color{color: var(--wp--preset--color--luminous-vivid-orange) !important;}.has-luminous-vivid-amber-color{color: var(--wp--preset--color--luminous-vivid-amber) !important;}.has-light-green-cyan-color{color: var(--wp--preset--color--light-green-cyan) !important;}.has-vivid-green-cyan-color{color: var(--wp--preset--color--vivid-green-cyan) !important;}.has-pale-cyan-blue-color{color: var(--wp--preset--color--pale-cyan-blue) !important;}.has-vivid-cyan-blue-color{color: var(--wp--preset--color--vivid-cyan-blue) !important;}.has-vivid-purple-color{color: var(--wp--preset--color--vivid-purple) !important;}.has-black-background-color{background-color: var(--wp--preset--color--black) !important;}.has-cyan-bluish-gray-background-color{background-color: var(--wp--preset--color--cyan-bluish-gray) !important;}.has-white-background-color{background-color: var(--wp--preset--color--white) !important;}.has-pale-pink-background-color{background-color: var(--wp--preset--color--pale-pink) !important;}.has-vivid-red-background-color{background-color: var(--wp--preset--color--vivid-red) !important;}.has-luminous-vivid-orange-background-color{background-color: var(--wp--preset--color--luminous-vivid-orange) !important;}.has-luminous-vivid-amber-background-color{background-color: var(--wp--preset--color--luminous-vivid-amber) !important;}.has-light-green-cyan-background-color{background-color: var(--wp--preset--color--light-green-cyan) !important;}.has-vivid-green-cyan-background-color{background-color: var(--wp--preset--color--vivid-green-cyan) !important;}.has-pale-cyan-blue-background-color{background-color: var(--wp--preset--color--pale-cyan-blue) !important;}.has-vivid-cyan-blue-background-color{background-color: var(--wp--preset--color--vivid-cyan-blue) !important;}.has-vivid-purple-background-color{background-color: var(--wp--preset--color--vivid-purple) !important;}.has-black-border-color{border-color: var(--wp--preset--color--black) !important;}.has-cyan-bluish-gray-border-color{border-color: var(--wp--preset--color--cyan-bluish-gray) !important;}.has-white-border-color{border-color: var(--wp--preset--color--white) !important;}.has-pale-pink-border-color{border-color: var(--wp--preset--color--pale-pink) !important;}.has-vivid-red-border-color{border-color: var(--wp--preset--color--vivid-red) !important;}.has-luminous-vivid-orange-border-color{border-color: var(--wp--preset--color--luminous-vivid-orange) !important;}.has-luminous-vivid-amber-border-color{border-color: var(--wp--preset--color--luminous-vivid-amber) !important;}.has-light-green-cyan-border-color{border-color: var(--wp--preset--color--light-green-cyan) !important;}.has-vivid-green-cyan-border-color{border-color: var(--wp--preset--color--vivid-green-cyan) !important;}.has-pale-cyan-blue-border-color{border-color: var(--wp--preset--color--pale-cyan-blue) !important;}.has-vivid-cyan-blue-border-color{border-color: var(--wp--preset--color--vivid-cyan-blue) !important;}.has-vivid-purple-border-color{border-color: var(--wp--preset--color--vivid-purple) !important;}.has-vivid-cyan-blue-to-vivid-purple-gradient-background{background: var(--wp--preset--gradient--vivid-cyan-blue-to-vivid-purple) !important;}.has-light-green-cyan-to-vivid-green-cyan-gradient-background{background: var(--wp--preset--gradient--light-green-cyan-to-vivid-green-cyan) !important;}.has-luminous-vivid-amber-to-luminous-vivid-orange-gradient-background{background: var(--wp--preset--gradient--luminous-vivid-amber-to-luminous-vivid-orange) !important;}.has-luminous-vivid-orange-to-vivid-red-gradient-background{background: var(--wp--preset--gradient--luminous-vivid-orange-to-vivid-red) !important;}.has-very-light-gray-to-cyan-bluish-gray-gradient-background{background: var(--wp--preset--gradient--very-light-gray-to-cyan-bluish-gray) !important;}.has-cool-to-warm-spectrum-gradient-background{background: var(--wp--preset--gradient--cool-to-warm-spectrum) !important;}.has-blush-light-purple-gradient-background{background: var(--wp--preset--gradient--blush-light-purple) !important;}.has-blush-bordeaux-gradient-background{background: var(--wp--preset--gradient--blush-bordeaux) !important;}.has-luminous-dusk-gradient-background{background: var(--wp--preset--gradient--luminous-dusk) !important;}.has-pale-ocean-gradient-background{background: var(--wp--preset--gradient--pale-ocean) !important;}.has-electric-grass-gradient-background{background: var(--wp--preset--gradient--electric-grass) !important;}.has-midnight-gradient-background{background: var(--wp--preset--gradient--midnight) !important;}.has-small-font-size{font-size: var(--wp--preset--font-size--small) !important;}.has-medium-font-size{font-size: var(--wp--preset--font-size--medium) !important;}.has-large-font-size{font-size: var(--wp--preset--font-size--large) !important;}.has-x-large-font-size{font-size: var(--wp--preset--font-size--x-large) !important;} :where(.wp-block-post-template.is-layout-flex){gap: 1.25em;}:where(.wp-block-post-template.is-layout-grid){gap: 1.25em;} :where(.wp-block-columns.is-layout-flex){gap: 2em;}:where(.wp-block-columns.is-layout-grid){gap: 2em;} :root :where(.wp-block-pullquote){font-size: 1.5em;line-height: 1.6;} </style> <link rel='stylesheet' id='arve-css' href='https://www.drugtargetreview.com/wp-content/plugins/advanced-responsive-video-embedder/build/main.css?ver=755e5bf2bfafc15e7cc1' type='text/css' media='all' /> <link rel='stylesheet' id='arve-pro-css' href='https://www.drugtargetreview.com/wp-content/plugins/arve-pro/build/main.css?ver=eea34735566740155d0f' type='text/css' media='all' /> <link rel='stylesheet' id='wpcf7-redirect-script-frontend-css' href='https://www.drugtargetreview.com/wp-content/plugins/contact-form-7-redirection-pro/assets/css/wpcf7-redirect-script-frontend-css.min.css?ver=62f62f3de500b9c925887338eccd4afd' type='text/css' media='all' /> <link rel='stylesheet' id='contact-form-7-css' href='https://www.drugtargetreview.com/wp-content/plugins/contact-form-7/includes/css/styles.css?ver=5.9.8' type='text/css' media='all' /> <style id='contact-form-7-inline-css' type='text/css'> .wpcf7 .wpcf7-recaptcha iframe {margin-bottom: 0;}.wpcf7 .wpcf7-recaptcha[data-align="center"] > div {margin: 0 auto;}.wpcf7 .wpcf7-recaptcha[data-align="right"] > div {margin: 0 0 0 auto;} </style> <link rel='stylesheet' id='ditty-news-ticker-font-css' href='https://www.drugtargetreview.com/wp-content/plugins/ditty-news-ticker/legacy/inc/static/libs/fontastic/styles.css?ver=3.1.48' type='text/css' media='all' /> <link rel='stylesheet' id='ditty-news-ticker-css' href='https://www.drugtargetreview.com/wp-content/plugins/ditty-news-ticker/legacy/inc/static/css/style.css?ver=3.1.48' type='text/css' media='all' /> <link rel='stylesheet' id='ditty-displays-css' href='https://www.drugtargetreview.com/wp-content/plugins/ditty-news-ticker/build/dittyDisplays.css?ver=3.1.48' type='text/css' media='all' /> <link rel='stylesheet' id='ditty-fontawesome-css' href='https://www.drugtargetreview.com/wp-content/plugins/ditty-news-ticker/includes/libs/fontawesome-6.4.0/css/all.css?ver=6.4.0' type='text/css' media='' /> <link rel='stylesheet' id='events-manager-css' href='https://www.drugtargetreview.com/wp-content/plugins/events-manager/includes/css/events-manager.min.css?ver=6.6.3' type='text/css' media='all' /> <style id='events-manager-inline-css' type='text/css'> body .em { --font-family : inherit; --font-weight : inherit; --font-size : 1em; --line-height : inherit; } </style> <link rel='stylesheet' id='events-manager-pro-css' href='https://www.drugtargetreview.com/wp-content/plugins/events-manager-pro/includes/css/events-manager-pro.css?ver=3.4.1' type='text/css' media='all' /> <link rel='stylesheet' id='cookie-law-info-css' href='https://www.drugtargetreview.com/wp-content/plugins/webtoffee-gdpr-cookie-consent/public/css/cookie-law-info-public.css?ver=2.4.0' type='text/css' media='all' /> <link rel='stylesheet' id='cookie-law-info-gdpr-css' href='https://www.drugtargetreview.com/wp-content/plugins/webtoffee-gdpr-cookie-consent/public/css/cookie-law-info-gdpr.css?ver=2.4.0' type='text/css' media='all' /> <style id='cookie-law-info-gdpr-inline-css' type='text/css'> .cli-modal-content, .cli-tab-content { background-color: #ffffff; }.cli-privacy-content-text, .cli-modal .cli-modal-dialog, .cli-tab-container p, a.cli-privacy-readmore { color: #000000; }.cli-tab-header { background-color: #f2f2f2; }.cli-tab-header, .cli-tab-header a.cli-nav-link,span.cli-necessary-caption,.cli-switch .cli-slider:after { color: #000000; }.cli-switch .cli-slider:before { background-color: #ffffff; }.cli-switch input:checked + .cli-slider:before { background-color: #ffffff; }.cli-switch .cli-slider { background-color: #e3e1e8; }.cli-switch input:checked + .cli-slider { background-color: #28a745; }.cli-modal-close svg { fill: #000000; }.cli-tab-footer .wt-cli-privacy-accept-all-btn { background-color: #00acad; color: #ffffff}.cli-tab-footer .wt-cli-privacy-accept-btn { background-color: #00acad; color: #ffffff}.cli-tab-header a:before{ border-right: 1px solid #000000; border-bottom: 1px solid #000000; } </style> <link rel='stylesheet' id='wpa-style-css' href='https://www.drugtargetreview.com/wp-content/plugins/wp-accessibility/css/wpa-style.css?ver=1.7.6' type='text/css' media='all' /> <style id='wpa-style-inline-css' type='text/css'> :root { --admin-bar-top : 7px; } </style> <link rel='stylesheet' id='subscribe-forms-css-css' href='https://www.drugtargetreview.com/wp-content/plugins/easy-social-share-buttons3/assets/modules/subscribe-forms.min.css?ver=9.3' type='text/css' media='all' /> <link rel='stylesheet' id='click2tweet-css-css' href='https://www.drugtargetreview.com/wp-content/plugins/easy-social-share-buttons3/assets/modules/click-to-tweet.min.css?ver=9.3' type='text/css' media='all' /> <link rel='stylesheet' id='easy-social-share-buttons-css' href='https://www.drugtargetreview.com/wp-content/plugins/easy-social-share-buttons3/assets/css/easy-social-share-buttons.min.css?ver=9.3' type='text/css' media='all' /> <link rel='stylesheet' id='ditty-posts-ticker-css' href='https://www.drugtargetreview.com/wp-content/plugins/ditty-posts-ticker/legacy/assets/css/style.css?ver=3.1.5' type='text/css' media='all' /> <link rel='stylesheet' id='searchwp-forms-css' href='https://www.drugtargetreview.com/wp-content/plugins/searchwp/assets/css/frontend/search-forms.css?ver=4.3.17' type='text/css' media='all' /> <link rel='stylesheet' id='cf7cf-style-css' href='https://www.drugtargetreview.com/wp-content/plugins/cf7-conditional-fields/style.css?ver=2.5' type='text/css' media='all' /> <link rel='stylesheet' id='ubermenu-css' href='https://www.drugtargetreview.com/wp-content/plugins/ubermenu/pro/assets/css/ubermenu.min.css?ver=3.8.1' type='text/css' media='all' /> <link rel='stylesheet' id='ubermenu-grey-white-css' href='https://www.drugtargetreview.com/wp-content/plugins/ubermenu/assets/css/skins/blackwhite.css?ver=62f62f3de500b9c925887338eccd4afd' type='text/css' media='all' /> <link rel='stylesheet' id='ubermenu-font-awesome-all-css' href='https://www.drugtargetreview.com/wp-content/plugins/ubermenu/assets/fontawesome/css/all.min.css?ver=62f62f3de500b9c925887338eccd4afd' type='text/css' media='all' /> <link rel='stylesheet' id='ubermenu-custom-stylesheet-css' href='https://www.drugtargetreview.com/wp-content/plugins/ubermenu/custom/custom.css?ver=3.8.1' type='text/css' media='all' /> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-includes/js/jquery/jquery.min.js?ver=3.7.1" id="jquery-core-js"></script> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-includes/js/jquery/jquery-migrate.min.js?ver=3.4.1" id="jquery-migrate-js"></script> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-content/plugins/peekaboo/assets/global.js?ver=1.1" id="peekaboo_plugin-js"></script> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-includes/js/jquery/ui/core.min.js?ver=1.13.3" id="jquery-ui-core-js"></script> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-includes/js/jquery/ui/mouse.min.js?ver=1.13.3" id="jquery-ui-mouse-js"></script> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-includes/js/jquery/ui/sortable.min.js?ver=1.13.3" id="jquery-ui-sortable-js"></script> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-includes/js/jquery/ui/datepicker.min.js?ver=1.13.3" id="jquery-ui-datepicker-js"></script> <script type="text/javascript" id="jquery-ui-datepicker-js-after"> /* <![CDATA[ */ jQuery(function(jQuery){jQuery.datepicker.setDefaults({"closeText":"Close","currentText":"Today","monthNames":["January","February","March","April","May","June","July","August","September","October","November","December"],"monthNamesShort":["Jan","Feb","Mar","Apr","May","Jun","Jul","Aug","Sep","Oct","Nov","Dec"],"nextText":"Next","prevText":"Previous","dayNames":["Sunday","Monday","Tuesday","Wednesday","Thursday","Friday","Saturday"],"dayNamesShort":["Sun","Mon","Tue","Wed","Thu","Fri","Sat"],"dayNamesMin":["S","M","T","W","T","F","S"],"dateFormat":"MM d, yy","firstDay":1,"isRTL":false});}); /* ]]> */ </script> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-includes/js/jquery/ui/resizable.min.js?ver=1.13.3" id="jquery-ui-resizable-js"></script> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-includes/js/jquery/ui/draggable.min.js?ver=1.13.3" id="jquery-ui-draggable-js"></script> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-includes/js/jquery/ui/controlgroup.min.js?ver=1.13.3" id="jquery-ui-controlgroup-js"></script> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-includes/js/jquery/ui/checkboxradio.min.js?ver=1.13.3" id="jquery-ui-checkboxradio-js"></script> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-includes/js/jquery/ui/button.min.js?ver=1.13.3" id="jquery-ui-button-js"></script> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-includes/js/jquery/ui/dialog.min.js?ver=1.13.3" id="jquery-ui-dialog-js"></script> <script type="text/javascript" id="events-manager-js-extra"> /* <![CDATA[ */ var EM = {"ajaxurl":"https:\/\/www.drugtargetreview.com\/wp-admin\/admin-ajax.php","locationajaxurl":"https:\/\/www.drugtargetreview.com\/wp-admin\/admin-ajax.php?action=locations_search","firstDay":"1","locale":"en","dateFormat":"yy-mm-dd","ui_css":"https:\/\/www.drugtargetreview.com\/wp-content\/plugins\/events-manager\/includes\/css\/jquery-ui\/build.min.css","show24hours":"0","is_ssl":"1","autocomplete_limit":"10","calendar":{"breakpoints":{"small":560,"medium":908,"large":false}},"phone":"","datepicker":{"format":"d\/m\/Y"},"search":{"breakpoints":{"small":650,"medium":850,"full":false}},"url":"https:\/\/www.drugtargetreview.com\/wp-content\/plugins\/events-manager","google_maps_api":"AIzaSyBI-BOK09R4i1op3O3wUFC1ovd4AU7VYgA","txt_search":"Search","txt_searching":"Searching...","txt_loading":"Loading...","cache":"1","api_nonce":"80bef059e0"}; /* ]]> */ </script> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-content/plugins/events-manager/includes/js/events-manager.js?ver=6.6.3" id="events-manager-js"></script> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-content/plugins/events-manager-pro/includes/js/events-manager-pro.js?ver=3.4.1" id="events-manager-pro-js"></script> <script type="text/javascript" id="cookie-law-info-js-extra"> /* <![CDATA[ */ var Cli_Data = {"nn_cookie_ids":["one_signal_sdk_db","cf_ob_info","cf_use_ob","ls_smartpush","free_subscription_only","vuid","VISITOR_INFO1_LIVE","GPS","YSC","IDE","advanced_ads_pro_server_info","advanced_ads_pro_visitor_referrer","bcookie","bscookie","lissc","wow.anonymousId","wow.schedule","wow.session","wow.utmvalues","_gid","_gat","li_sugr","lang","lidc","UserMatchHistory","advanced_ads_browser_width","advanced_ads_page_impressions","_ga"],"non_necessary_cookies":{"advertising-targeting":["VISITOR_INFO1_LIVE","IDE","advanced_ads_pro_server_info","advanced_ads_pro_visitor_referrer","bscookie","li_sugr","UserMatchHistory","advanced_ads_browser_width","advanced_ads_page_impressions"],"analytics":["vuid","GPS","bcookie","lissc","wow.anonymousId","wow.schedule","wow.session","wow.utmvalues","_gid","_gat","lang","lidc","_ga"],"performance":["one_signal_sdk_db","cf_ob_info","cf_use_ob","ls_smartpush","free_subscription_only","YSC"]},"cookielist":{"necessary":{"id":63248,"status":true,"priority":0,"title":"Necessary","strict":true,"default_state":false,"ccpa_optout":false,"loadonstart":false},"advertising-targeting":{"id":63250,"status":true,"priority":0,"title":"Advertising & Targeting","strict":false,"default_state":true,"ccpa_optout":false,"loadonstart":false},"analytics":{"id":63251,"status":true,"priority":0,"title":"Analytics","strict":false,"default_state":true,"ccpa_optout":false,"loadonstart":false},"performance":{"id":63940,"status":true,"priority":0,"title":"Performance","strict":false,"default_state":true,"ccpa_optout":false,"loadonstart":false}},"ajax_url":"https:\/\/www.drugtargetreview.com\/wp-admin\/admin-ajax.php","current_lang":"en","security":"41407dc3f0","eu_countries":["GB"],"geoIP":"disabled","use_custom_geolocation_api":"","custom_geolocation_api":"https:\/\/geoip.cookieyes.com\/geoip\/checker\/result.php","consentVersion":"2","strictlyEnabled":["necessary","obligatoire"],"cookieDomain":"","privacy_length":"250","ccpaEnabled":"","ccpaRegionBased":"","ccpaBarEnabled":"","ccpaType":"gdpr","triggerDomRefresh":"","secure_cookies":""}; var log_object = {"ajax_url":"https:\/\/www.drugtargetreview.com\/wp-admin\/admin-ajax.php"}; /* ]]> */ </script> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-content/plugins/webtoffee-gdpr-cookie-consent/public/js/cookie-law-info-public.js?ver=2.4.0" id="cookie-law-info-js"></script> <script type="text/javascript" id="advanced-ads-advanced-js-js-extra"> /* <![CDATA[ */ var advads_options = {"blog_id":"1","privacy":{"enabled":false,"state":"not_needed"}}; /* ]]> */ </script> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-content/uploads/289/679/public/assets/js/333.js?ver=1.55.0" id="advanced-ads-advanced-js-js"></script> <script type="text/javascript" id="advanced_ads_pro/visitor_conditions-js-extra"> /* <![CDATA[ */ var advanced_ads_pro_visitor_conditions = {"referrer_cookie_name":"advanced_ads_pro_visitor_referrer","referrer_exdays":"365","page_impr_cookie_name":"advanced_ads_page_impressions","page_impr_exdays":"730"}; /* ]]> */ </script> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-content/uploads/289/985/489/853/463/170.js?ver=2.27.0" id="advanced_ads_pro/visitor_conditions-js"></script> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-content/plugins/wp-accessibility/js/fingerprint.min.js?ver=1.7.6" id="wpa-fingerprintjs-js"></script> <link rel="https://api.w.org/" href="https://www.drugtargetreview.com/wp-json/" /><link rel="EditURI" type="application/rsd+xml" title="RSD" href="https://www.drugtargetreview.com/xmlrpc.php?rsd" /> <link rel='shortlink' href='https://www.drugtargetreview.com/?p=104912' /> <link rel="alternate" title="oEmbed (JSON)" type="application/json+oembed" href="https://www.drugtargetreview.com/wp-json/oembed/1.0/embed?url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F" /> <link rel="alternate" title="oEmbed (XML)" type="text/xml+oembed" href="https://www.drugtargetreview.com/wp-json/oembed/1.0/embed?url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F&format=xml" /> <script type='text/javascript' data-cfasync='false'>/* Function to detect opted out users */ function __gaTrackerIsOptedOut() { return document.cookie.indexOf(disableStr + '=true') > -1; } /* Disable tracking if the opt-out cookie exists. */ var disableStr = 'ga-disable-UA-10556842-14'; if ( __gaTrackerIsOptedOut() ) { window[disableStr] = true; } /* Opt-out function */ function __gaTrackerOptout() { document.cookie = disableStr + '=true; expires=Thu, 31 Dec 2099 23:59:59 UTC; path=/'; window[disableStr] = true; } (function(i,s,o,g,r,a,m){i['GoogleAnalyticsObject']=r;i[r]=i[r]||function(){ (i[r].q=i[r].q||[]).push(arguments)},i[r].l=1*new Date();a=s.createElement(o), m=s.getElementsByTagName(o)[0];a.async=1;a.src=g;m.parentNode.insertBefore(a,m) })(window,document,'script','//www.google-analytics.com/analytics.js','__gaTracker'); __gaTracker('create', 'UA-10556842-14', 'auto'); __gaTracker('set', 'forceSSL', true); __gaTracker('require', 'displayfeatures'); __gaTracker('require', 'linkid', 'linkid.js'); __gaTracker('set', 'dimension1', 'issue-3-2022 past-issue'); __gaTracker('set', 'dimension4', 'antibodies assays cns crispr drug-development drug-discovery neurosciences proteomics vaccine'); __gaTracker('set', 'dimension6', 'article'); __gaTracker('set', 'dimension7', 'imaging omics screening targets'); __gaTracker('set', 'dimension8', 'drug-target-review'); __gaTracker('set', 'dimension9', 'ecapon'); __gaTracker('set', 'dimension10', '20220914'); __gaTracker('send','pageview',{'anonymizeIp': true}); </script> <script type='text/javascript'> var _wow = _wow || []; (function () { try{ _wow.push(['setClientId', '96c22c17-e6e3-46d8-936e-89c284cdd9d2']); _wow.push(['enableDownloadTracking']); // set custom values _wow.push(['SetCustomData', 'imaging omics screening targets','antibodies assays cns crispr drug-development drug-discovery neurosciences proteomics vaccine','article']); // track page _wow.push(['trackPageView']); var d = document, g = d.createElement('script'), s = d.getElementsByTagName('script')[0]; g.type = 'text/javascript'; g.defer = true; g.async = true; g.src = '//t.wowanalytics.co.uk/Scripts/tracker.js'; s.parentNode.insertBefore(g, s); }catch(err){}})(); </script> <script type="text/javascript"> function scrsize_load_url(div_id, adbutler_id, placement_id, width, height) { var ad_content = ' \ <script type="text/javascript">if (!window.AdButler){(function(){var s = document.createElement("script"); s.async = true; s.type = "text/javascript";s.src = "https://servedbyadbutler.com/app.js";var n = document.getElementsByTagName("script")[0]; n.parentNode.insertBefore(s, n);}());}<\/script> \ <script type="text/javascript"> \ var AdButler = AdButler || {}; AdButler.ads = AdButler.ads || []; \ var abkw = window.abkw || ""; \ var plc' + placement_id + ' = window.plc' + placement_id + ' || 0; \ AdButler.ads.push({handler: function(opt){ AdButler.register(' + adbutler_id + ', ' + placement_id + ', [' + width + ', ' + height + '], "' + div_id + '", opt); }, opt: { place: plc' + placement_id + '++, keywords: abkw, domain: "servedbyadbutler.com", click:"CLICK_MACRO_PLACEHOLDER" }}); \ <\/script> \ '; //console.log(ad_content); jQuery("#" + div_id).append(ad_content); /* var ajaxurl = "https://www.drugtargetreview.com/wp-admin/admin-ajax.php"; var data = { 'action': 'screensize_content', 'div_id': div_id, 'adbutler_id': adbutler_id, 'placement_id': placement_id, 'width': width, 'height': height }; jQuery.post(ajaxurl, data, function(response) { jQuery("#" + div_id).append(response); }); */ } </script>   <script>(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer','GTM-KM6ZDN2');</script>   <script src="https://www.googleoptimize.com/optimize.js?id=OPT-NTHPPD3"></script>   <script async src="https://www.googletagmanager.com/gtag/js?id=AW-964653157"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'AW-964653157'); </script> <script> gtag('event', 'page_view', { 'send_to': 'AW-964653157', 'value': 'replace with value', 'items': [{ 'id': 'replace with value', 'location_id': 'replace with value', 'google_business_vertical': 'custom' }] }); </script> <style id="ubermenu-custom-generated-css"> /** Font Awesome 4 Compatibility **/ .fa{font-style:normal;font-variant:normal;font-weight:normal;font-family:FontAwesome;} /** UberMenu Responsive Styles (Breakpoint Setting) **/ @media screen and (min-width: 1181px){ .ubermenu{ display:block !important; } .ubermenu-responsive .ubermenu-item.ubermenu-hide-desktop{ display:none !important; } .ubermenu-responsive.ubermenu-retractors-responsive .ubermenu-retractor-mobile{ display:none; } /* Top level items full height */ .ubermenu.ubermenu-horizontal.ubermenu-items-vstretch .ubermenu-nav{ display:flex; align-items:stretch; } .ubermenu.ubermenu-horizontal.ubermenu-items-vstretch .ubermenu-item.ubermenu-item-level-0{ display:flex; flex-direction:column; } .ubermenu.ubermenu-horizontal.ubermenu-items-vstretch .ubermenu-item.ubermenu-item-level-0 > .ubermenu-target{ flex:1; display:flex; align-items:center; flex-wrap:wrap; } .ubermenu.ubermenu-horizontal.ubermenu-items-vstretch .ubermenu-item.ubermenu-item-level-0 > .ubermenu-target > .ubermenu-target-divider{ position:static; flex-basis:100%; } .ubermenu.ubermenu-horizontal.ubermenu-items-vstretch .ubermenu-item.ubermenu-item-level-0 > .ubermenu-target.ubermenu-item-layout-image_left > .ubermenu-target-text{ padding-left:1em; } .ubermenu.ubermenu-horizontal.ubermenu-items-vstretch .ubermenu-item.ubermenu-item-level-0 > .ubermenu-target.ubermenu-item-layout-image_right > .ubermenu-target-text{ padding-right:1em; } .ubermenu.ubermenu-horizontal.ubermenu-items-vstretch .ubermenu-item.ubermenu-item-level-0 > .ubermenu-target.ubermenu-item-layout-image_above, .ubermenu.ubermenu-horizontal.ubermenu-items-vstretch .ubermenu-item.ubermenu-item-level-0 > .ubermenu-target.ubermenu-item-layout-image_below{ flex-direction:column; } .ubermenu.ubermenu-horizontal.ubermenu-items-vstretch .ubermenu-item.ubermenu-item-level-0 > .ubermenu-submenu-drop{ top:100%; } .ubermenu.ubermenu-horizontal.ubermenu-items-vstretch .ubermenu-item-level-0:not(.ubermenu-align-right) + .ubermenu-item.ubermenu-align-right{ margin-left:auto; } .ubermenu.ubermenu-horizontal.ubermenu-items-vstretch .ubermenu-item.ubermenu-item-level-0 > .ubermenu-target.ubermenu-content-align-left{ justify-content:flex-start; } .ubermenu.ubermenu-horizontal.ubermenu-items-vstretch .ubermenu-item.ubermenu-item-level-0 > .ubermenu-target.ubermenu-content-align-center{ justify-content:center; } .ubermenu.ubermenu-horizontal.ubermenu-items-vstretch .ubermenu-item.ubermenu-item-level-0 > .ubermenu-target.ubermenu-content-align-right{ justify-content:flex-end; } /* Force current submenu always open but below others */ .ubermenu-force-current-submenu .ubermenu-item-level-0.ubermenu-current-menu-item > .ubermenu-submenu-drop, .ubermenu-force-current-submenu .ubermenu-item-level-0.ubermenu-current-menu-ancestor > .ubermenu-submenu-drop { display: block!important; opacity: 1!important; visibility: visible!important; margin: 0!important; top: auto!important; height: auto; z-index:19; } /* Invert Horizontal menu to make subs go up */ .ubermenu-invert.ubermenu-horizontal .ubermenu-item-level-0 > .ubermenu-submenu-drop, .ubermenu-invert.ubermenu-horizontal.ubermenu-items-vstretch .ubermenu-item.ubermenu-item-level-0>.ubermenu-submenu-drop{ top:auto; bottom:100%; } .ubermenu-invert.ubermenu-horizontal.ubermenu-sub-indicators .ubermenu-item-level-0.ubermenu-has-submenu-drop > .ubermenu-target > .ubermenu-sub-indicator{ transform:rotate(180deg); } /* Make second level flyouts fly up */ .ubermenu-invert.ubermenu-horizontal .ubermenu-submenu .ubermenu-item.ubermenu-active > .ubermenu-submenu-type-flyout{ top:auto; bottom:0; } /* Clip the submenus properly when inverted */ .ubermenu-invert.ubermenu-horizontal .ubermenu-item-level-0 > .ubermenu-submenu-drop{ clip: rect(-5000px,5000px,auto,-5000px); } /* Invert Vertical menu to make subs go left */ .ubermenu-invert.ubermenu-vertical .ubermenu-item-level-0 > .ubermenu-submenu-drop{ right:100%; left:auto; } .ubermenu-invert.ubermenu-vertical.ubermenu-sub-indicators .ubermenu-item-level-0.ubermenu-item-has-children > .ubermenu-target > .ubermenu-sub-indicator{ right:auto; left:10px; transform:rotate(90deg); } .ubermenu-vertical.ubermenu-invert .ubermenu-item > .ubermenu-submenu-drop { clip: rect(-5000px,5000px,5000px,-5000px); } /* Vertical Flyout > Flyout */ .ubermenu-vertical.ubermenu-invert.ubermenu-sub-indicators .ubermenu-has-submenu-drop > .ubermenu-target{ padding-left:25px; } .ubermenu-vertical.ubermenu-invert .ubermenu-item > .ubermenu-target > .ubermenu-sub-indicator { right:auto; left:10px; transform:rotate(90deg); } .ubermenu-vertical.ubermenu-invert .ubermenu-item > .ubermenu-submenu-drop.ubermenu-submenu-type-flyout, .ubermenu-vertical.ubermenu-invert .ubermenu-submenu-type-flyout > .ubermenu-item > .ubermenu-submenu-drop { right: 100%; left: auto; } .ubermenu-responsive-toggle{ display:none; } } @media screen and (max-width: 1180px){ .ubermenu-responsive-toggle, .ubermenu-sticky-toggle-wrapper { display: block; } .ubermenu-responsive{ width:100%; max-height:600px; visibility:visible; overflow:visible; -webkit-transition:max-height 1s ease-in; transition:max-height .3s ease-in; } .ubermenu-responsive.ubermenu-mobile-accordion:not(.ubermenu-mobile-modal):not(.ubermenu-in-transition):not(.ubermenu-responsive-collapse){ max-height:none; } .ubermenu-responsive.ubermenu-items-align-center{ text-align:left; } .ubermenu-responsive.ubermenu{ margin:0; } .ubermenu-responsive.ubermenu .ubermenu-nav{ display:block; } .ubermenu-responsive.ubermenu-responsive-nocollapse, .ubermenu-repsonsive.ubermenu-no-transitions{ display:block; max-height:none; } .ubermenu-responsive.ubermenu-responsive-collapse{ max-height:none; visibility:visible; overflow:visible; } .ubermenu-responsive.ubermenu-responsive-collapse{ max-height:0; overflow:hidden !important; visibility:hidden; } .ubermenu-responsive.ubermenu-in-transition, .ubermenu-responsive.ubermenu-in-transition .ubermenu-nav{ overflow:hidden !important; visibility:visible; } .ubermenu-responsive.ubermenu-responsive-collapse:not(.ubermenu-in-transition){ border-top-width:0; border-bottom-width:0; } .ubermenu-responsive.ubermenu-responsive-collapse .ubermenu-item .ubermenu-submenu{ display:none; } .ubermenu-responsive .ubermenu-item-level-0{ width:50%; } .ubermenu-responsive.ubermenu-responsive-single-column .ubermenu-item-level-0{ float:none; clear:both; width:100%; } .ubermenu-responsive .ubermenu-item.ubermenu-item-level-0 > .ubermenu-target{ border:none; box-shadow:none; } .ubermenu-responsive .ubermenu-item.ubermenu-has-submenu-flyout{ position:static; } .ubermenu-responsive.ubermenu-sub-indicators .ubermenu-submenu-type-flyout .ubermenu-has-submenu-drop > .ubermenu-target > .ubermenu-sub-indicator{ transform:rotate(0); right:10px; left:auto; } .ubermenu-responsive .ubermenu-nav .ubermenu-item .ubermenu-submenu.ubermenu-submenu-drop{ width:100%; min-width:100%; max-width:100%; top:auto; left:0 !important; } .ubermenu-responsive.ubermenu-has-border .ubermenu-nav .ubermenu-item .ubermenu-submenu.ubermenu-submenu-drop{ left: -1px !important; /* For borders */ } .ubermenu-responsive .ubermenu-submenu.ubermenu-submenu-type-mega > .ubermenu-item.ubermenu-column{ min-height:0; border-left:none; float:left; /* override left/center/right content alignment */ display:block; } .ubermenu-responsive .ubermenu-item.ubermenu-active > .ubermenu-submenu.ubermenu-submenu-type-mega{ max-height:none; height:auto;/*prevent overflow scrolling since android is still finicky*/ overflow:visible; } .ubermenu-responsive.ubermenu-transition-slide .ubermenu-item.ubermenu-in-transition > .ubermenu-submenu-drop{ max-height:1000px; /* because of slide transition */ } .ubermenu .ubermenu-submenu-type-flyout .ubermenu-submenu-type-mega{ min-height:0; } .ubermenu.ubermenu-responsive .ubermenu-column, .ubermenu.ubermenu-responsive .ubermenu-column-auto{ min-width:50%; } .ubermenu.ubermenu-responsive .ubermenu-autoclear > .ubermenu-column{ clear:none; } .ubermenu.ubermenu-responsive .ubermenu-column:nth-of-type(2n+1){ clear:both; } .ubermenu.ubermenu-responsive .ubermenu-submenu-retractor-top:not(.ubermenu-submenu-retractor-top-2) .ubermenu-column:nth-of-type(2n+1){ clear:none; } .ubermenu.ubermenu-responsive .ubermenu-submenu-retractor-top:not(.ubermenu-submenu-retractor-top-2) .ubermenu-column:nth-of-type(2n+2){ clear:both; } .ubermenu-responsive-single-column-subs .ubermenu-submenu .ubermenu-item { float: none; clear: both; width: 100%; min-width: 100%; } .ubermenu.ubermenu-responsive .ubermenu-tabs, .ubermenu.ubermenu-responsive .ubermenu-tabs-group, .ubermenu.ubermenu-responsive .ubermenu-tab, .ubermenu.ubermenu-responsive .ubermenu-tab-content-panel{ /** TABS SHOULD BE 100% ACCORDION */ width:100%; min-width:100%; max-width:100%; left:0; } .ubermenu.ubermenu-responsive .ubermenu-tabs, .ubermenu.ubermenu-responsive .ubermenu-tab-content-panel{ min-height:0 !important;/* Override Inline Style from JS */ } .ubermenu.ubermenu-responsive .ubermenu-tabs{ z-index:15; } .ubermenu.ubermenu-responsive .ubermenu-tab-content-panel{ z-index:20; } /* Tab Layering */ .ubermenu-responsive .ubermenu-tab{ position:relative; } .ubermenu-responsive .ubermenu-tab.ubermenu-active{ position:relative; z-index:20; } .ubermenu-responsive .ubermenu-tab > .ubermenu-target{ border-width:0 0 1px 0; } .ubermenu-responsive.ubermenu-sub-indicators .ubermenu-tabs > .ubermenu-tabs-group > .ubermenu-tab.ubermenu-has-submenu-drop > .ubermenu-target > .ubermenu-sub-indicator{ transform:rotate(0); right:10px; left:auto; } .ubermenu-responsive .ubermenu-tabs > .ubermenu-tabs-group > .ubermenu-tab > .ubermenu-tab-content-panel{ top:auto; border-width:1px; } .ubermenu-responsive .ubermenu-tab-layout-bottom > .ubermenu-tabs-group{ /*position:relative;*/ } .ubermenu-reponsive .ubermenu-item-level-0 > .ubermenu-submenu-type-stack{ /* Top Level Stack Columns */ position:relative; } .ubermenu-responsive .ubermenu-submenu-type-stack .ubermenu-column, .ubermenu-responsive .ubermenu-submenu-type-stack .ubermenu-column-auto{ /* Stack Columns */ width:100%; max-width:100%; } .ubermenu-responsive .ubermenu-item-mini{ /* Mini items */ min-width:0; width:auto; float:left; clear:none !important; } .ubermenu-responsive .ubermenu-item.ubermenu-item-mini > a.ubermenu-target{ padding-left:20px; padding-right:20px; } .ubermenu-responsive .ubermenu-item.ubermenu-hide-mobile{ /* Hiding items */ display:none !important; } .ubermenu-responsive.ubermenu-hide-bkgs .ubermenu-submenu.ubermenu-submenu-bkg-img{ /** Hide Background Images in Submenu */ background-image:none; } .ubermenu.ubermenu-responsive .ubermenu-item-level-0.ubermenu-item-mini{ min-width:0; width:auto; } .ubermenu-vertical .ubermenu-item.ubermenu-item-level-0{ width:100%; } .ubermenu-vertical.ubermenu-sub-indicators .ubermenu-item-level-0.ubermenu-item-has-children > .ubermenu-target > .ubermenu-sub-indicator{ right:10px; left:auto; transform:rotate(0); } .ubermenu-vertical .ubermenu-item.ubermenu-item-level-0.ubermenu-relative.ubermenu-active > .ubermenu-submenu-drop.ubermenu-submenu-align-vertical_parent_item{ top:auto; } .ubermenu.ubermenu-responsive .ubermenu-tabs{ position:static; } /* Tabs on Mobile with mouse (but not click) - leave space to hover off */ .ubermenu:not(.ubermenu-is-mobile):not(.ubermenu-submenu-indicator-closes) .ubermenu-submenu .ubermenu-tab[data-ubermenu-trigger="mouseover"] .ubermenu-tab-content-panel, .ubermenu:not(.ubermenu-is-mobile):not(.ubermenu-submenu-indicator-closes) .ubermenu-submenu .ubermenu-tab[data-ubermenu-trigger="hover_intent"] .ubermenu-tab-content-panel{ margin-left:6%; width:94%; min-width:94%; } /* Sub indicator close visibility */ .ubermenu.ubermenu-submenu-indicator-closes .ubermenu-active > .ubermenu-target > .ubermenu-sub-indicator-close{ display:block; display: flex; align-items: center; justify-content: center; } .ubermenu.ubermenu-submenu-indicator-closes .ubermenu-active > .ubermenu-target > .ubermenu-sub-indicator{ display:none; } .ubermenu .ubermenu-tabs .ubermenu-tab-content-panel{ box-shadow: 0 5px 10px rgba(0,0,0,.075); } /* When submenus and items go full width, move items back to appropriate positioning */ .ubermenu .ubermenu-submenu-rtl { direction: ltr; } /* Fixed position mobile menu */ .ubermenu.ubermenu-mobile-modal{ position:fixed; z-index:9999999; opacity:1; top:0; left:0; width:100%; width:100vw; max-width:100%; max-width:100vw; height:100%; height:calc(100vh - calc(100vh - 100%)); height:-webkit-fill-available; max-height:calc(100vh - calc(100vh - 100%)); max-height:-webkit-fill-available; border:none; box-sizing:border-box; display:flex; flex-direction:column; justify-content:flex-start; overflow-y:auto !important; /* for non-accordion mode */ overflow-x:hidden !important; overscroll-behavior: contain; transform:scale(1); transition-duration:.1s; transition-property: all; } .ubermenu.ubermenu-mobile-modal.ubermenu-mobile-accordion.ubermenu-interaction-press{ overflow-y:hidden !important; } .ubermenu.ubermenu-mobile-modal.ubermenu-responsive-collapse{ overflow:hidden !important; opacity:0; transform:scale(.9); visibility:hidden; } .ubermenu.ubermenu-mobile-modal .ubermenu-nav{ flex:1; overflow-y:auto !important; overscroll-behavior: contain; } .ubermenu.ubermenu-mobile-modal .ubermenu-item-level-0{ margin:0; } .ubermenu.ubermenu-mobile-modal .ubermenu-mobile-close-button{ border:none; background:none; border-radius:0; padding:1em; color:inherit; display:inline-block; text-align:center; font-size:14px; } .ubermenu.ubermenu-mobile-modal .ubermenu-mobile-footer .ubermenu-mobile-close-button{ width: 100%; display: flex; align-items: center; justify-content: center; } .ubermenu.ubermenu-mobile-modal .ubermenu-mobile-footer .ubermenu-mobile-close-button .ubermenu-icon-essential, .ubermenu.ubermenu-mobile-modal .ubermenu-mobile-footer .ubermenu-mobile-close-button .fas.fa-times{ margin-right:.2em; } /* Header/Footer Mobile content */ .ubermenu .ubermenu-mobile-header, .ubermenu .ubermenu-mobile-footer{ display:block; text-align:center; color:inherit; } /* Accordion submenus mobile (single column tablet) */ .ubermenu.ubermenu-responsive-single-column.ubermenu-mobile-accordion.ubermenu-interaction-press .ubermenu-item > .ubermenu-submenu-drop, .ubermenu.ubermenu-responsive-single-column.ubermenu-mobile-accordion.ubermenu-interaction-press .ubermenu-tab > .ubermenu-tab-content-panel{ box-sizing:border-box; border-left:none; border-right:none; box-shadow:none; } .ubermenu.ubermenu-responsive-single-column.ubermenu-mobile-accordion.ubermenu-interaction-press .ubermenu-item.ubermenu-active > .ubermenu-submenu-drop, .ubermenu.ubermenu-responsive-single-column.ubermenu-mobile-accordion.ubermenu-interaction-press .ubermenu-tab.ubermenu-active > .ubermenu-tab-content-panel{ position:static; } /* Accordion indented - remove borders and extra spacing from headers */ .ubermenu.ubermenu-mobile-accordion-indent .ubermenu-submenu.ubermenu-submenu-drop, .ubermenu.ubermenu-mobile-accordion-indent .ubermenu-submenu .ubermenu-item-header.ubermenu-has-submenu-stack > .ubermenu-target{ border:none; } .ubermenu.ubermenu-mobile-accordion-indent .ubermenu-submenu .ubermenu-item-header.ubermenu-has-submenu-stack > .ubermenu-submenu-type-stack{ padding-top:0; } /* Accordion dropdown indentation padding */ .ubermenu.ubermenu-mobile-accordion-indent .ubermenu-submenu-drop .ubermenu-submenu-drop .ubermenu-item > .ubermenu-target, .ubermenu.ubermenu-mobile-accordion-indent .ubermenu-submenu-drop .ubermenu-tab-content-panel .ubermenu-item > .ubermenu-target{ padding-left:calc( var(--ubermenu-accordion-indent) * 2 ); } .ubermenu.ubermenu-mobile-accordion-indent .ubermenu-submenu-drop .ubermenu-submenu-drop .ubermenu-submenu-drop .ubermenu-item > .ubermenu-target, .ubermenu.ubermenu-mobile-accordion-indent .ubermenu-submenu-drop .ubermenu-tab-content-panel .ubermenu-tab-content-panel .ubermenu-item > .ubermenu-target{ padding-left:calc( var(--ubermenu-accordion-indent) * 3 ); } .ubermenu.ubermenu-mobile-accordion-indent .ubermenu-submenu-drop .ubermenu-submenu-drop .ubermenu-submenu-drop .ubermenu-submenu-drop .ubermenu-item > .ubermenu-target, .ubermenu.ubermenu-mobile-accordion-indent .ubermenu-submenu-drop .ubermenu-tab-content-panel .ubermenu-tab-content-panel .ubermenu-tab-content-panel .ubermenu-item > .ubermenu-target{ padding-left:calc( var(--ubermenu-accordion-indent) * 4 ); } /* Reverse Accordion dropdown indentation padding */ .rtl .ubermenu.ubermenu-mobile-accordion-indent .ubermenu-submenu-drop .ubermenu-submenu-drop .ubermenu-item > .ubermenu-target, .rtl .ubermenu.ubermenu-mobile-accordion-indent .ubermenu-submenu-drop .ubermenu-tab-content-panel .ubermenu-item > .ubermenu-target{ padding-left:0; padding-right:calc( var(--ubermenu-accordion-indent) * 2 ); } .rtl .ubermenu.ubermenu-mobile-accordion-indent .ubermenu-submenu-drop .ubermenu-submenu-drop .ubermenu-submenu-drop .ubermenu-item > .ubermenu-target, .rtl .ubermenu.ubermenu-mobile-accordion-indent .ubermenu-submenu-drop .ubermenu-tab-content-panel .ubermenu-tab-content-panel .ubermenu-item > .ubermenu-target{ padding-left:0; padding-right:calc( var(--ubermenu-accordion-indent) * 3 ); } .rtl .ubermenu.ubermenu-mobile-accordion-indent .ubermenu-submenu-drop .ubermenu-submenu-drop .ubermenu-submenu-drop .ubermenu-submenu-drop .ubermenu-item > .ubermenu-target, .rtl .ubermenu.ubermenu-mobile-accordion-indent .ubermenu-submenu-drop .ubermenu-tab-content-panel .ubermenu-tab-content-panel .ubermenu-tab-content-panel .ubermenu-item > .ubermenu-target{ padding-left:0; padding-right:calc( var(--ubermenu-accordion-indent) * 4 ); } .ubermenu-responsive-toggle{ display:block; } } @media screen and (max-width: 480px){ .ubermenu.ubermenu-responsive .ubermenu-item-level-0{ width:100%; } .ubermenu.ubermenu-responsive .ubermenu-column, .ubermenu.ubermenu-responsive .ubermenu-column-auto{ min-width:100%; } .ubermenu .ubermenu-autocolumn:not(:first-child), .ubermenu .ubermenu-autocolumn:not(:first-child) .ubermenu-submenu-type-stack{ padding-top:0; } .ubermenu .ubermenu-autocolumn:not(:last-child), .ubermenu .ubermenu-autocolumn:not(:last-child) .ubermenu-submenu-type-stack{ padding-bottom:0; } .ubermenu .ubermenu-autocolumn > .ubermenu-submenu-type-stack > .ubermenu-item-normal:first-child{ margin-top:0; } /* Accordion submenus mobile */ .ubermenu.ubermenu-responsive.ubermenu-mobile-accordion.ubermenu-interaction-press .ubermenu-item > .ubermenu-submenu-drop, .ubermenu.ubermenu-responsive.ubermenu-mobile-accordion.ubermenu-interaction-press .ubermenu-tab > .ubermenu-tab-content-panel{ box-shadow:none; box-sizing:border-box; border-left:none; border-right:none; } .ubermenu.ubermenu-responsive.ubermenu-mobile-accordion.ubermenu-interaction-press .ubermenu-item.ubermenu-active > .ubermenu-submenu-drop, .ubermenu.ubermenu-responsive.ubermenu-mobile-accordion.ubermenu-interaction-press .ubermenu-tab.ubermenu-active > .ubermenu-tab-content-panel{ position:static; } } /* Status: Loaded from Transient */ @media \0screen { .ubermenu .ubermenu-image { width: auto } } /* Prevent height distortion in IE8. */ </style>  <meta name="twitter:card" content="summary_large_image" /> <meta name="twitter:site" content="@DrugTargetRev" /> <meta name="twitter:title" content="Drug Target Review – Issue 3 2022" /> <meta name="twitter:description" content="In this issue are articles on synthetically engineered bacteria to deliver therapeutics, how single-molecule …" /> <meta name="twitter:image" content="https://www.drugtargetreview.com/wp-content/uploads/DTR-Issue-3-Feature-750-x-500.jpg"> <meta name="twitter:image:alt" content="DTR Issue 3 Feature 750 x 500">  <script type="text/javascript">var essb_settings = {"ajax_url":"https:\/\/www.drugtargetreview.com\/wp-admin\/admin-ajax.php","essb3_nonce":"6b27a80c94","essb3_plugin_url":"https:\/\/www.drugtargetreview.com\/wp-content\/plugins\/easy-social-share-buttons3","essb3_stats":true,"essb3_ga":true,"essb3_ga_ntg":false,"essb3_ga_mode":"layers","blog_url":"https:\/\/www.drugtargetreview.com\/","post_id":"104912"};</script><script>advads_items = { conditions: {}, display_callbacks: {}, display_effect_callbacks: {}, hide_callbacks: {}, backgrounds: {}, effect_durations: {}, close_functions: {}, showed: [] };</script><style type="text/css" id="drugt-layer-custom-css"></style>   <script data-cfasync='false' type='text/javascript'> var _wow = _wow || []; (function () { try{ _wow.push(['setClientId', '96c22c17-e6e3-46d8-936e-89c284cdd9d2']); _wow.push(['enableDownloadTracking']); _wow.push(['trackPageView']); var d = document, g = d.createElement('script'), s = d.getElementsByTagName('script')[0]; g.type = 'text/javascript'; g.defer = true; g.async = true; g.src = '//t.gatorleads.co.uk/Scripts/tracker.js'; s.parentNode.insertBefore(g, s); }catch(err){}})(); </script> <script type="text/javascript"> var advadsCfpQueue = []; var advadsCfpAd = function( adID ){ if ( 'undefined' == typeof advadsProCfp ) { advadsCfpQueue.push( adID ) } else { advadsProCfp.addElement( adID ) } }; </script> <meta name="onesignal" content="wordpress-plugin"/> <script> window.OneSignal = window.OneSignal || []; OneSignal.push( function() { OneSignal.SERVICE_WORKER_UPDATER_PATH = "OneSignalSDKUpdaterWorker.js.php"; OneSignal.SERVICE_WORKER_PATH = "OneSignalSDKWorker.js.php"; OneSignal.SERVICE_WORKER_PARAM = { scope: "/" }; OneSignal.setDefaultNotificationUrl("https://www.drugtargetreview.com"); var oneSignal_options = {}; window._oneSignalInitOptions = oneSignal_options; oneSignal_options['wordpress'] = true; oneSignal_options['appId'] = 'ef205720-1780-4939-bf29-1bf36ec3b684'; oneSignal_options['allowLocalhostAsSecureOrigin'] = true; oneSignal_options['welcomeNotification'] = { }; oneSignal_options['welcomeNotification']['title'] = ""; oneSignal_options['welcomeNotification']['message'] = ""; oneSignal_options['path'] = "https://www.drugtargetreview.com/wp-content/plugins/onesignal-free-web-push-notifications/sdk_files/"; oneSignal_options['persistNotification'] = true; oneSignal_options['promptOptions'] = { }; oneSignal_options['promptOptions']['actionMessage'] = "We would like to send you push notifications. Turn them off anytime via browser settings."; oneSignal_options['promptOptions']['acceptButtonText'] = "ALLOW"; oneSignal_options['promptOptions']['cancelButtonText'] = "NO THANKS"; oneSignal_options['notifyButton'] = { }; oneSignal_options['notifyButton']['enable'] = true; oneSignal_options['notifyButton']['position'] = 'bottom-right'; oneSignal_options['notifyButton']['theme'] = 'default'; oneSignal_options['notifyButton']['size'] = 'medium'; oneSignal_options['notifyButton']['showCredit'] = false; oneSignal_options['notifyButton']['text'] = {}; OneSignal.init(window._oneSignalInitOptions); OneSignal.showSlidedownPrompt(); }); function documentInitOneSignal() { var oneSignal_elements = document.getElementsByClassName("OneSignal-prompt"); var oneSignalLinkClickHandler = function(event) { OneSignal.push(['registerForPushNotifications']); event.preventDefault(); }; for(var i = 0; i < oneSignal_elements.length; i++) oneSignal_elements[i].addEventListener('click', oneSignalLinkClickHandler, false); } if (document.readyState === 'complete') { documentInitOneSignal(); } else { window.addEventListener("load", function(event){ documentInitOneSignal(); }); } </script> <script type="text/javascript"> if ( typeof advadsGATracking === 'undefined' ) { window.advadsGATracking = { delayedAds: {}, deferedAds: {} }; } </script> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-content/themes/dtr19/js/toggle_view4.js"></script> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-content/themes/dtr19/js/facet_scroller.js"></script> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-content/themes/dtr19/js/hide_empty_facets.js"></script> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-content/themes/dtr19/js/random_order.js"></script> </head> <body class="article-template-default single single-article postid-104912 single-format-standard zform z-lead-form essb-9.3 aa-prefix-drugt- aa-disabled-page"> <div id="tickerContainer"> <div id="mtphr-dnt-56707" class="mtphr-dnt mtphr-dnt-56707 mtphr-dnt-default mtphr-dnt-scroll mtphr-dnt-scroll-left"><div class="mtphr-dnt-wrapper mtphr-dnt-clearfix"><h3 class="mtphr-dnt-title mtphr-dnt-inline-title">Recommended</h3><div class="mtphr-dnt-tick-container" style="padding-top:10px;padding-bottom:10px;"><div class="mtphr-dnt-tick-contents"><div class="mtphr-dnt-tick mtphr-dnt-default-tick mtphr-dnt-clearfix "><a href="https://www.drugtargetreview.com/webinar/153145/overcoming-critical-challenges-in-ai-driven-drug-discovery/?zcs=NewsTicker&campaign_source=NewsTicker&utm_medium=email&utm_source=content&utm_campaign=Overcoming%20critical%20challenges%20in%20AI-driven%20drug%20discovery%2025%20Nov%2024" target="_self">New webinar: Overcoming critical challenges in AI-driven drug discovery </a></div><div class="mtphr-dnt-tick mtphr-dnt-default-tick mtphr-dnt-clearfix "><a href="https://www.drugtargetreview.com/webinar/151803/rapid-functional-cell-based-activity-profiling-of-multi-receptor-targeted-anti-obesity-therapies/?zcs=NewsTicker&campaign_source=Newsticker_Euro2oct" target="_self">Watch on demand: Rapid cell-based profiling of multi-target anti-obesity drugs Watch here!</a></div><div class="mtphr-dnt-tick mtphr-dnt-default-tick mtphr-dnt-clearfix "><a href="https://www.drugtargetreview.com/whitepaper/143234/beyond-the-lab-cell-and-gene-therapy/?zcs=NewsTicker&campaign_source=NewsTicker" target="_self">Download now: Unlock the power of stem cell therapy and discover the potential for new therapies for primary open-angle glaucoma</a></div><div class="mtphr-dnt-tick mtphr-dnt-default-tick mtphr-dnt-clearfix "><a href="https://www.drugtargetreview.com/whitepaper/153630/beyond-the-lab-antibodies/?zcs=NewsTicker&campaign_source=NewsTicker&utm_medium=referral&utm_source=news%20ticker&utm_campaign=Beyond%20the%20Lab%20report%2025%20Oct%2024" target="_self">Brand new Beyond the Lab report on antibodies… Download NOW!</a></div></div></div></div></div></div> <div id="headerContainer"> <header id="banner" role="banner"> <div id="mainLogo"><a href="https://www.drugtargetreview.com"><img data-lazyloaded="1" src="data:image/gif;base64,R0lGODdhAQABAPAAAMPDwwAAACwAAAAAAQABAAACAkQBADs=" data-src="https://www.drugtargetreview.com/wp-content/themes/dtr19/images/dtr-logo-large.png"><noscript><img src="https://www.drugtargetreview.com/wp-content/themes/dtr19/images/dtr-logo-large.png"></noscript></a></div><div id="responsiveLogins"><script> var data_responsive = { action: 'is_user_logged_in' }; jQuery.post('/wp-admin/admin-ajax.php', data_responsive, function(response) { var params_responsive = jQuery.parseJSON(response); var manage_responsive; var nav_image_responsive; if(params_responsive.state == 'logout') { manage_responsive = '<div id="responsiveManage"><a href="https://www.drugtargetreview.com/zmember/subscribers/manage_account?lasturl=https://www.drugtargetreview.com/article/104912/drug-target-review-issue-3-2022/" title="Manage account" rel="nofollow"><img src="https://www.drugtargetreview.com/wp-content/themes/dtr19/images/manage-responsive.png" /></a></div>'; nav_image_responsive = 'logout-responsive.png'; } else { manage_responsive = ''; nav_image_responsive = 'login-responsive.png'; } jQuery('#subscription_status_responsive').replaceWith('<div id="responsive'+params_responsive.title_first+'"><a href="https://www.drugtargetreview.com/zmember/subscribers/'+params_responsive.url_first+'?lasturl=https://www.drugtargetreview.com/article/104912/drug-target-review-issue-3-2022/" title="'+params_responsive.title_first+'" rel="nofollow"><img src="https://www.drugtargetreview.com/wp-content/themes/dtr19/images/'+nav_image_responsive+'" /></a></div>'+manage_responsive); }); </script> <div id="subscription_status_responsive" style="float: right; margin-right: 10%;"> <p><img data-lazyloaded="1" src="data:image/gif;base64,R0lGODdhAQABAPAAAMPDwwAAACwAAAAAAQABAAACAkQBADs=" data-src="https://www.drugtargetreview.com/wp-content/themes/dtr19/images/ajax-loader-responsive.gif"><noscript><img src="https://www.drugtargetreview.com/wp-content/themes/dtr19/images/ajax-loader-responsive.gif"></noscript></p> </div></div> <div id="headerBanner"> <div id="ad27"></div> <script type="text/javascript"> jQuery(document).ready(function() { var cur_width = jQuery(document).width(); console.log("Screen width: " + cur_width); if ( cur_width > 0 ) { console.log("Showing show-if-gt in ad27 (167548)"); scrsize_load_url("ad27", 167548, 367658, 300, 123); } }); </script> </div> <div id="headerRight"> <div id="headerTop"><div id="links"><p><a href="https://www.drugtargetreview.com/about-us">About us</a> | <a href="https://www.drugtargetreview.com/advertising-editorial/">Advertise with us</a> | <a href="https://www.drugtargetreview.com/contact-us/">Contact us</a></p> </div><div id="social"><p><a href="https://www.linkedin.com/company/drug-target-review" target="blank"><i class="fab fa-linkedin-in"></i></a> <a href="https://www.facebook.com/DrugTargetReview" target="blank"><i class="fab fa-facebook"></i></a> <a href="https://twitter.com/DrugTargetRev" target="blank"><i class="fab fa-twitter"></i></a>  <a href="http://feeds.feedburner.com/DrugTargetReview" target="blank"><i class="fas fa-rss"></i></a></p></div></div> <div id="headerSearch"> <form role="search" method="get" class="search-form" action="https://www.drugtargetreview.com/"> <input type="search" class="search-field" placeholder="Search..." value="" name="s" title="Search" /> </form> </div> <div id="logins"><script> var data = { action: 'is_user_logged_in' }; jQuery.post('/wp-admin/admin-ajax.php', data, function(response) { var params = jQuery.parseJSON(response); jQuery('#subscription_status').replaceWith('<p><a href="https://www.drugtargetreview.com/zmember/subscribers/'+params.state+'?lasturl=https://www.drugtargetreview.com/article/104912/drug-target-review-issue-3-2022/" title="'+params.title_first+'" rel="nofollow">'+params.title_first+'</a> | <a href="https://www.drugtargetreview.com/zmember/subscribers/'+params.url_second+'?lasturl=https://www.drugtargetreview.com/article/104912/drug-target-review-issue-3-2022/" title="'+params.title_second+'" rel="nofollow">'+params.title_second+'</a> | <a href="https://www.drugtargetreview.com/zmember/subscribers/register_new?lasturl=https://www.drugtargetreview.com/article/104912/drug-target-review-issue-3-2022/">Email Sign-up</a></p> '); }); </script> <div id="subscription_status"> <p><img data-lazyloaded="1" src="data:image/gif;base64,R0lGODdhAQABAPAAAMPDwwAAACwAAAAAAQABAAACAkQBADs=" data-src="https://www.drugtargetreview.com/wp-content/themes/dtr19/images/ajax-loader.gif"><noscript><img src="https://www.drugtargetreview.com/wp-content/themes/dtr19/images/ajax-loader.gif"></noscript></p> </div></div> </div> </header> </div> <div id="navContainerPrimary"> <nav>  <a class="ubermenu-responsive-toggle ubermenu-responsive-toggle-main ubermenu-skin-grey-white ubermenu-loc- ubermenu-responsive-toggle-content-align-left ubermenu-responsive-toggle-align-full " tabindex="0" data-ubermenu-target="ubermenu-main-15" ><i class="fas fa-bars" ></i>Menu</a><nav id="ubermenu-main-15" class="ubermenu ubermenu-nojs ubermenu-main ubermenu-menu-15 ubermenu-responsive ubermenu-responsive-1180 ubermenu-responsive-collapse ubermenu-horizontal ubermenu-transition-slide ubermenu-trigger-hover_intent ubermenu-skin-grey-white ubermenu-bar-align-left ubermenu-items-align-left ubermenu-bound ubermenu-sub-indicators ubermenu-retractors-responsive ubermenu-submenu-indicator-closes"><ul id="ubermenu-nav-main-15" class="ubermenu-nav" data-title="Primary Nav"><li id="menu-item-15495" class="ubermenu-item ubermenu-item-type-post_type ubermenu-item-object-page ubermenu-item-home ubermenu-item-15495 ubermenu-item-level-0 ubermenu-column ubermenu-column-auto" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" title="Home" href="https://www.drugtargetreview.com/" tabindex="0"><span class="ubermenu-target-title ubermenu-target-text">Home</span></a></li><li id="menu-item-112848" class="ubermenu-item ubermenu-item-type-post_type ubermenu-item-object-research_hub ubermenu-item-112848 ubermenu-item-level-0 ubermenu-column ubermenu-column-auto" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="https://www.drugtargetreview.com/research_hub/cancer-research-hub/" tabindex="0"><span class="ubermenu-target-title ubermenu-target-text">Cancer Research hub</span></a></li><li id="menu-item-15496" class="ubermenu-item ubermenu-item-type-post_type_archive ubermenu-item-object-news ubermenu-item-15496 ubermenu-item-level-0 ubermenu-column ubermenu-column-auto" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" title="News" href="https://www.drugtargetreview.com/news/" tabindex="0"><span class="ubermenu-target-title ubermenu-target-text">News</span></a></li><li id="menu-item-15498" class="ubermenu-item ubermenu-item-type-post_type_archive ubermenu-item-object-article ubermenu-current-menu-item ubermenu-item-15498 ubermenu-item-level-0 ubermenu-column ubermenu-column-auto" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" title="Articles" href="https://www.drugtargetreview.com/article/" tabindex="0"><span class="ubermenu-target-title ubermenu-target-text">Articles</span></a></li><li id="menu-item-15499" class="ubermenu-item ubermenu-item-type-post_type ubermenu-item-object-page ubermenu-item-15499 ubermenu-item-level-0 ubermenu-column ubermenu-column-auto" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" title="Issue Archive" href="https://www.drugtargetreview.com/publications/" tabindex="0"><span class="ubermenu-target-title ubermenu-target-text">Publications</span></a></li><li id="menu-item-58908" class="ubermenu-item ubermenu-item-type-post_type_archive ubermenu-item-object-video ubermenu-item-58908 ubermenu-item-level-0 ubermenu-column ubermenu-column-auto" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" title="Videos" href="https://www.drugtargetreview.com/video/" tabindex="0"><span class="ubermenu-target-title ubermenu-target-text">Videos</span></a></li><li id="menu-item-103631" class="ubermenu-item ubermenu-item-type-post_type_archive ubermenu-item-object-podcasts ubermenu-item-103631 ubermenu-item-level-0 ubermenu-column ubermenu-column-auto" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="https://www.drugtargetreview.com/podcasts/" tabindex="0"><span class="ubermenu-target-title ubermenu-target-text">Podcasts</span></a></li><li id="menu-item-15500" class="ubermenu-item ubermenu-item-type-post_type_archive ubermenu-item-object-webinar ubermenu-item-15500 ubermenu-item-level-0 ubermenu-column ubermenu-column-auto" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" title="Webinars" href="https://www.drugtargetreview.com/webinar/" tabindex="0"><span class="ubermenu-target-title ubermenu-target-text">Webinars</span></a></li><li id="menu-item-15502" class="ubermenu-item ubermenu-item-type-post_type_archive ubermenu-item-object-whitepaper ubermenu-item-15502 ubermenu-item-level-0 ubermenu-column ubermenu-column-auto" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" title="Whitepapers / App Notes" href="https://www.drugtargetreview.com/whitepaper/" tabindex="0"><span class="ubermenu-target-title ubermenu-target-text">Whitepapers / App Notes</span></a></li><li id="menu-item-15503" class="ubermenu-item ubermenu-item-type-post_type_archive ubermenu-item-object-company_profile ubermenu-item-15503 ubermenu-item-level-0 ubermenu-column ubermenu-column-auto" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" title="Content Hubs" href="https://www.drugtargetreview.com/company_profile/" tabindex="0"><span class="ubermenu-target-title ubermenu-target-text">Content Hubs</span></a></li><li id="menu-item-15504" class="ubermenu-item ubermenu-item-type-post_type_archive ubermenu-item-object-event ubermenu-item-has-children ubermenu-item-15504 ubermenu-item-level-0 ubermenu-column ubermenu-column-auto ubermenu-has-submenu-drop ubermenu-has-submenu-flyout" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" title="Events" href="https://www.drugtargetreview.com/events/" tabindex="0"><span class="ubermenu-target-title ubermenu-target-text">Events</span><i class='ubermenu-sub-indicator fas fa-angle-down'></i></a><ul class="ubermenu-submenu ubermenu-submenu-id-15504 ubermenu-submenu-type-flyout ubermenu-submenu-drop ubermenu-submenu-align-left_edge_item" ><li id="menu-item-111535" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-111535 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-1" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="https://drugdiscovery.events/liverpool-breakfast-briefing/"><span class="ubermenu-target-title ubermenu-target-text">Liverpool Breakfast Briefing</span></a></li><li id="menu-item-113216" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-113216 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-1" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="https://www.drugtargetreview.com/events/"><span class="ubermenu-target-title ubermenu-target-text">Industry Events</span></a></li><li class="ubermenu-retractor ubermenu-retractor-mobile"><i class="fas fa-times"></i> Close</li></ul></li></ul></nav>  </nav> </div> <div id="navContainerSecondary"> <nav> <div class="menu-topic-menu-container"><ul id="menu-topic-menu" class="menu"><li id="menu-item-17601" class="menu-item menu-item-type-taxonomy menu-item-object-core_topic current-article-ancestor current-menu-parent current-article-parent menu-item-17601"><a title="Targets" href="https://www.drugtargetreview.com/core_topic/targets/">Targets</a></li> <li id="menu-item-17602" class="menu-item menu-item-type-taxonomy menu-item-object-core_topic current-article-ancestor current-menu-parent current-article-parent menu-item-17602"><a title="Screening" href="https://www.drugtargetreview.com/core_topic/screening/">Screening</a></li> <li id="menu-item-17603" class="menu-item menu-item-type-taxonomy menu-item-object-core_topic menu-item-17603"><a title="Stem Cells" href="https://www.drugtargetreview.com/core_topic/stem-cells/">Stem Cells</a></li> <li id="menu-item-17606" class="menu-item menu-item-type-taxonomy menu-item-object-core_topic menu-item-17606"><a title="Hit-to-Lead" href="https://www.drugtargetreview.com/core_topic/hit-to-lead/">Hit-to-Lead</a></li> <li id="menu-item-17604" class="menu-item menu-item-type-taxonomy menu-item-object-core_topic current-article-ancestor current-menu-parent current-article-parent menu-item-17604"><a title="Omics" href="https://www.drugtargetreview.com/core_topic/omics/">Omics</a></li> <li id="menu-item-17528" class="menu-item menu-item-type-taxonomy menu-item-object-core_topic current-article-ancestor current-menu-parent current-article-parent menu-item-17528"><a title="Imaging" href="https://www.drugtargetreview.com/core_topic/imaging/">Imaging</a></li> <li id="menu-item-17605" class="menu-item menu-item-type-taxonomy menu-item-object-core_topic menu-item-17605"><a title="Informatics" href="https://www.drugtargetreview.com/core_topic/informatics/">Informatics</a></li> <li id="menu-item-17531" class="menu-item menu-item-type-taxonomy menu-item-object-core_topic menu-item-17531"><a title="Regulation & Legislation" href="https://www.drugtargetreview.com/core_topic/regs-legs/">Regs & Legs</a></li> <li id="menu-item-111656" class="menu-item menu-item-type-taxonomy menu-item-object-core_topic menu-item-111656"><a href="https://www.drugtargetreview.com/core_topic/women-in-stem/">Women in Stem</a></li> </ul></div></nav> </div> <div id="contentContainer"> <div id="outerWrapper"> <div id="innerWrapper"> <div id="wrapLeft" class="wraps"> <div id="ad1"></div> <script type="text/javascript"> jQuery(document).ready(function() { var cur_width = jQuery(document).width(); console.log("Screen width: " + cur_width); if ( cur_width > 1597 ) { console.log("Showing show-if-gt in ad1 (167548)"); scrsize_load_url("ad1", 167548, 259435, 210, 900); } }); </script>  </div> <div id="content"> <style> [v-cloak] { display: none; } </style> <div id="left"> <div id="fullLeft"> <div class="cpt"><span>article</span></div> <main> <article class="single"> <h1>Drug Target Review – Issue 3 2022</h1> <div id="metaInfo"> <div class="dateTime"> <p>By <a href="https://www.drugtargetreview.com/content_author/drug-target-review/" rel="tag">Drug Target Review</a></p> <div class="leadDate"><p>14 September 2022</p></div> </div> <div id="essb"> <h3>Shares</h3> <div class="essb-total center" data-network-list="facebook,twitter,linkedin,print,mail" data-url="https://www.drugtargetreview.com/article/104912/drug-target-review-issue-3-2022/" data-full-number="false" data-post="104912" ><div class="essb-total-value essb-block">7</div></div></div> <div id="essbShares"> <h3>Share this post</h3> <div class="essb_links essb_counter_modern_right essb_displayed_shortcode essb_share essb_template_metro-retina essb_1083901612 essb_width_columns essb_width_columns_3 essb_links_center print-no" id="essb_displayed_shortcode_1083901612" data-essb-postid="104912" data-essb-position="shortcode" data-essb-button-style="icon" data-essb-template="metro-retina" data-essb-counter-pos="right" data-essb-url="https://www.drugtargetreview.com/article/104912/drug-target-review-issue-3-2022/" data-essb-fullurl="https://www.drugtargetreview.com/article/104912/drug-target-review-issue-3-2022/" data-essb-instance="1083901612"><ul class="essb_links_list essb_force_hide_name essb_force_hide"><li class="essb_item essb_link_facebook nolightbox"> <a href="https://www.facebook.com/sharer/sharer.php?u=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F&t=Drug+Target+Review+%E2%80%93+Issue+3+2022" title="Share on Facebook" onclick="essb.window('https://www.facebook.com/sharer/sharer.php?u=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F&t=Drug+Target+Review+%E2%80%93+Issue+3+2022','facebook','1083901612'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-facebook essb-s-bgh-facebook essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_facebook"></span><span class="essb_network_name essb_noname"></span></a></li><li class="essb_item essb_link_twitter nolightbox"> <a href="#" title="Share on Twitter" onclick="essb.window('https://twitter.com/intent/tweet?text=Drug%20Target%20Review%20–%20Issue%203%202022&url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F&counturl=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F','twitter','1083901612'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-twitter essb-s-bgh-twitter essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_twitter"></span><span class="essb_network_name essb_noname"></span></a></li><li class="essb_item essb_link_linkedin nolightbox"> <a href="https://www.linkedin.com/shareArticle?mini=true&ro=true&trk=EasySocialShareButtons&title=Drug+Target+Review+%E2%80%93+Issue+3+2022&url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F" title="Share on LinkedIn" onclick="essb.window('https://www.linkedin.com/shareArticle?mini=true&ro=true&trk=EasySocialShareButtons&title=Drug+Target+Review+%E2%80%93+Issue+3+2022&url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F','linkedin','1083901612'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-linkedin essb-s-bgh-linkedin essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_linkedin"></span><span class="essb_network_name essb_noname"></span></a></li><li class="essb_item essb_link_print nolightbox"> <a href="#" title="Share on Print" onclick="essb.print('1083901612'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-print essb-s-bgh-print essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_print"></span><span class="essb_network_name essb_noname"></span></a></li><li class="essb_item essb_link_mail nolightbox"> <a href="/cdn-cgi/l/email-protection#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" title="Share on Email" onclick="essb.tracking_only('', 'mail', '1083901612', true);" target="_self" rel="nofollow" class="nolightbox essb-s-bg-mail essb-s-bgh-mail essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network"><span class="essb_icon essb_icon_mail"></span><span class="essb_network_name essb_noname"></span></a></li><li class="essb_item essb_link_more nolightbox"> <a href="#" title="Share on More Button" onclick="essb.toggle_more_popup('1083901612'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-more essb-s-bgh-more essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_more"></span><span class="essb_network_name essb_noname"></span></a></li></ul></div><div class="essb_morepopup essb_morepopup_1083901612 essb_morepopup_shortcode essb-forced-hidden"> <div class="essb_morepopup_header"> <span>Share via</span> <a href="#" class="essb_morepopup_close" onclick="essb.toggle_less_popup('1083901612'); return false;"><svg style="width: 24px; height: 24px; padding: 5px;" height="32" viewBox="0 0 32 32" width="32" version="1.1" xmlns="http://www.w3.org/2000/svg"><path d="M32,25.7c0,0.7-0.3,1.3-0.8,1.8l-3.7,3.7c-0.5,0.5-1.1,0.8-1.9,0.8c-0.7,0-1.3-0.3-1.8-0.8L16,23.3l-7.9,7.9C7.6,31.7,7,32,6.3,32c-0.8,0-1.4-0.3-1.9-0.8l-3.7-3.7C0.3,27.1,0,26.4,0,25.7c0-0.8,0.3-1.3,0.8-1.9L8.7,16L0.8,8C0.3,7.6,0,6.9,0,6.3c0-0.8,0.3-1.3,0.8-1.9l3.7-3.6C4.9,0.2,5.6,0,6.3,0C7,0,7.6,0.2,8.1,0.8L16,8.7l7.9-7.9C24.4,0.2,25,0,25.7,0c0.8,0,1.4,0.2,1.9,0.8l3.7,3.6C31.7,4.9,32,5.5,32,6.3c0,0.7-0.3,1.3-0.8,1.8L23.3,16l7.9,7.9C31.7,24.4,32,25,32,25.7z"/></svg></a> </div> <div class="essb_morepopup_content essb_morepopup_content_1083901612"><div class="essb_links essb_displayed_more_popup essb_share essb_template_metro-retina essb_405935443 essb_width_columns essb_width_columns_3 print-no" id="essb_displayed_more_popup_405935443" data-essb-postid="104912" data-essb-position="more_popup" data-essb-button-style="button" data-essb-template="metro-retina" data-essb-counter-pos="left" data-essb-url="https://www.drugtargetreview.com/article/104912/drug-target-review-issue-3-2022/" data-essb-fullurl="https://www.drugtargetreview.com/article/104912/drug-target-review-issue-3-2022/" data-essb-instance="405935443"><ul class="essb_links_list"><li class="essb_item essb_link_facebook nolightbox"> <a href="https://www.facebook.com/sharer/sharer.php?u=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F&t=Drug+Target+Review+%E2%80%93+Issue+3+2022" title="Share on Facebook" onclick="essb.window('https://www.facebook.com/sharer/sharer.php?u=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F&t=Drug+Target+Review+%E2%80%93+Issue+3+2022','facebook','405935443'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-facebook essb-s-bgh-facebook essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_facebook"></span><span class="essb_network_name">Facebook</span></a></li><li class="essb_item essb_link_facebook nolightbox"> <a href="https://www.facebook.com/plugins/like.php?href=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F" title="Share on Like" onclick="essb.window('https://www.facebook.com/plugins/like.php?href=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F','facebook_like','405935443'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-facebook essb-s-bgh-facebook essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_facebook-official"></span><span class="essb_network_name">Like</span></a></li><li class="essb_item essb_link_twitter nolightbox"> <a href="#" title="Share on Twitter" onclick="essb.window('https://twitter.com/intent/tweet?text=Drug%20Target%20Review%20–%20Issue%203%202022&url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F&counturl=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F','twitter','405935443'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-twitter essb-s-bgh-twitter essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_twitter"></span><span class="essb_network_name">Twitter</span></a></li><li class="essb_item essb_link_pinterest nolightbox"> <a href="#" title="Share on Pinterest" onclick="essb.pinterest_picker('405935443'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-pinterest essb-s-bgh-pinterest essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_pinterest"></span><span class="essb_network_name">Pinterest</span></a></li><li class="essb_item essb_link_linkedin nolightbox"> <a href="https://www.linkedin.com/shareArticle?mini=true&ro=true&trk=EasySocialShareButtons&title=Drug+Target+Review+%E2%80%93+Issue+3+2022&url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F" title="Share on LinkedIn" onclick="essb.window('https://www.linkedin.com/shareArticle?mini=true&ro=true&trk=EasySocialShareButtons&title=Drug+Target+Review+%E2%80%93+Issue+3+2022&url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F','linkedin','405935443'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-linkedin essb-s-bgh-linkedin essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_linkedin"></span><span class="essb_network_name">LinkedIn</span></a></li><li class="essb_item essb_link_digg nolightbox"> <a href="http://digg.com/submit?url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F&title=Drug+Target+Review+%E2%80%93+Issue+3+2022" title="Share on Digg" onclick="essb.window('http://digg.com/submit?url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F&title=Drug+Target+Review+%E2%80%93+Issue+3+2022','digg','405935443'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-digg essb-s-bgh-digg essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_digg"></span><span class="essb_network_name">Digg</span></a></li><li class="essb_item essb_link_del nolightbox"> <a href="https://del.icio.us/login?log=out&provider=essb&title=Drug+Target+Review+%E2%80%93+Issue+3+2022&url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F&v=5" title="Share on Del" onclick="essb.window('https://del.icio.us/login?log=out&provider=essb&title=Drug+Target+Review+%E2%80%93+Issue+3+2022&url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F&v=5','del','405935443'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-del essb-s-bgh-del essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_del"></span><span class="essb_network_name">Del</span></a></li><li class="essb_item essb_link_tumblr nolightbox"> <a href="https://www.tumblr.com/widgets/share/tool?canonicalUrl=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F&title=Drug+Target+Review+%E2%80%93+Issue+3+2022&posttype=link" title="Share on Tumblr" onclick="essb.window('https://www.tumblr.com/widgets/share/tool?canonicalUrl=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F&title=Drug+Target+Review+%E2%80%93+Issue+3+2022&posttype=link','tumblr','405935443'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-tumblr essb-s-bgh-tumblr essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_tumblr"></span><span class="essb_network_name">Tumblr</span></a></li><li class="essb_item essb_link_vk nolightbox"> <a href="http://vk.com/share.php?url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F&image=https://www.drugtargetreview.com/wp-content/uploads/DTR-Issue-3-Feature-750-x-500.jpg&description=In+this+issue+are+articles+on+engineered+bacteria%2C+how+smFRET+was+used+to+image+GPCRs+and+an+assay+to+identify+COVID-19+drugs.&title=Drug+Target+Review+%E2%80%93+Issue+3+2022" title="Share on VKontakte" onclick="essb.window('http://vk.com/share.php?url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F&image=https://www.drugtargetreview.com/wp-content/uploads/DTR-Issue-3-Feature-750-x-500.jpg&description=In+this+issue+are+articles+on+engineered+bacteria%2C+how+smFRET+was+used+to+image+GPCRs+and+an+assay+to+identify+COVID-19+drugs.&title=Drug+Target+Review+%E2%80%93+Issue+3+2022','vk','405935443'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-vk essb-s-bgh-vk essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_vk"></span><span class="essb_network_name">VKontakte</span></a></li><li class="essb_item essb_link_print nolightbox"> <a href="#" title="Share on Print" onclick="essb.print('405935443'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-print essb-s-bgh-print essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_print"></span><span class="essb_network_name">Print</span></a></li><li class="essb_item essb_link_mail nolightbox"> <a href="/cdn-cgi/l/email-protection#28175b5d4a424d4b5c157e415b415c0d1a185c40415b0d1a185b415c4d0d1a18405c5c585b0d1b690d1a6e0d1a6e5f5f5f064c5a5d4f5c495a4f4d5c5a4d5e414d5f064b47450e494558134a474c511560410d1a6b0d1a185c40415b0d1a184549510d1a184a4d0d1a1841465c4d5a4d5b5c41464f0d1a1851475d0d1b690d1a186c5a5d4f0d1a187c495a4f4d5c0d1a187a4d5e414d5f0d1a180d6d1a0d10180d111b0d1a18615b5b5d4d0d1a181b0d1a181a181a1a0d1a190d1a187c40415b0d1a18415b0d1a185c404d0d1a18444146430d1b690d1a18405c5c585b0d1b690d1a6e0d1a6e5f5f5f064c5a5d4f5c495a4f4d5c5a4d5e414d5f064b47450d1a6e495a5c414b444d0d1a6e19181c11191a0d1a6e4c5a5d4f055c495a4f4d5c055a4d5e414d5f05415b5b5d4d051b051a181a1a0d1a6e" title="Share on Email" onclick="essb.tracking_only('', 'mail', '405935443', true);" target="_self" rel="nofollow" class="nolightbox essb-s-bg-mail essb-s-bgh-mail essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network"><span class="essb_icon essb_icon_mail"></span><span class="essb_network_name">Email</span></a></li><li class="essb_item essb_link_reddit nolightbox"> <a href="https://reddit.com/submit?url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F&title=Drug+Target+Review+%E2%80%93+Issue+3+2022" title="Share on Reddit" onclick="essb.window('https://reddit.com/submit?url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F&title=Drug+Target+Review+%E2%80%93+Issue+3+2022','reddit','405935443'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-reddit essb-s-bgh-reddit essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_reddit"></span><span class="essb_network_name">Reddit</span></a></li><li class="essb_item essb_link_buffer nolightbox"> <a href="https://bufferapp.com/add?url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F&text=Drug+Target+Review+%E2%80%93+Issue+3+2022&via=&picture=&count=horizontal&source=button" title="Share on Buffer" onclick="essb.window('https://bufferapp.com/add?url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F&text=Drug+Target+Review+%E2%80%93+Issue+3+2022&via=&picture=&count=horizontal&source=button','buffer','405935443'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-buffer essb-s-bgh-buffer essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_buffer"></span><span class="essb_network_name">Buffer</span></a></li><li class="essb_item essb_link_love nolightbox"> <a href="#" title="Share on Love This" onclick="essb.loveThis('405935443'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-love essb-s-bgh-love essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_love"></span><span class="essb_network_name">Love This</span></a></li><li class="essb_item essb_link_weibo nolightbox"> <a href="http://service.weibo.com/share/share.php?url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F&title=Drug+Target+Review+%E2%80%93+Issue+3+2022&pic=https://www.drugtargetreview.com/wp-content/uploads/DTR-Issue-3-Feature-750-x-500.jpg" title="Share on Weibo" onclick="essb.window('http://service.weibo.com/share/share.php?url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F&title=Drug+Target+Review+%E2%80%93+Issue+3+2022&pic=https://www.drugtargetreview.com/wp-content/uploads/DTR-Issue-3-Feature-750-x-500.jpg','weibo','405935443'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-weibo essb-s-bgh-weibo essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_weibo"></span><span class="essb_network_name">Weibo</span></a></li><li class="essb_item essb_link_pocket nolightbox"> <a href="https://getpocket.com/save?title=Drug+Target+Review+%E2%80%93+Issue+3+2022&url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F" title="Share on Pocket" onclick="essb.window('https://getpocket.com/save?title=Drug+Target+Review+%E2%80%93+Issue+3+2022&url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F','pocket','405935443'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-pocket essb-s-bgh-pocket essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_pocket"></span><span class="essb_network_name">Pocket</span></a></li><li class="essb_item essb_link_xing nolightbox"> <a href="https://www.xing.com/spi/shares/new?url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F" title="Share on Xing" onclick="essb.window('https://www.xing.com/spi/shares/new?url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F','xing','405935443'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-xing essb-s-bgh-xing essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_xing"></span><span class="essb_network_name">Xing</span></a></li><li class="essb_item essb_link_ok nolightbox"> <a href="https://connect.ok.ru/offer?url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F&title=Drug+Target+Review+%E2%80%93+Issue+3+2022&imageUrl=https://www.drugtargetreview.com/wp-content/uploads/DTR-Issue-3-Feature-750-x-500.jpg" title="Share on Odnoklassniki" onclick="essb.window('https://connect.ok.ru/offer?url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F&title=Drug+Target+Review+%E2%80%93+Issue+3+2022&imageUrl=https://www.drugtargetreview.com/wp-content/uploads/DTR-Issue-3-Feature-750-x-500.jpg','ok','405935443'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-ok essb-s-bgh-ok essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_ok"></span><span class="essb_network_name">Odnoklassniki</span></a></li><li class="essb_item essb_link_whatsapp nolightbox"> <a href="whatsapp://send?text=Drug%20Target%20Review%20–%20Issue%203%202022%20https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F" title="Share on WhatsApp" onclick="essb.tracking_only('', 'whatsapp', '405935443', true);" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-whatsapp essb-s-bgh-whatsapp essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_whatsapp"></span><span class="essb_network_name">WhatsApp</span></a></li><li class="essb_item essb_link_meneame nolightbox"> <a href="http://www.meneame.net/submit.php?url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F" title="Share on Meneame" onclick="essb.window('http://www.meneame.net/submit.php?url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F','meneame','405935443'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-meneame essb-s-bgh-meneame essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_meneame"></span><span class="essb_network_name">Meneame</span></a></li><li class="essb_item essb_link_blogger nolightbox"> <a href="https://www.blogger.com/blog_this.pyra?t&u=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F&n=Drug+Target+Review+%E2%80%93+Issue+3+2022" title="Share on Blogger" onclick="essb.window('https://www.blogger.com/blog_this.pyra?t&u=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F&n=Drug+Target+Review+%E2%80%93+Issue+3+2022','blogger','405935443'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-blogger essb-s-bgh-blogger essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_blogger"></span><span class="essb_network_name">Blogger</span></a></li><li class="essb_item essb_link_amazon nolightbox"> <a href="https://www.amazon.com/gp/wishlist/static-add?u=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F&t=Drug+Target+Review+%E2%80%93+Issue+3+2022" title="Share on Amazon" onclick="essb.window('http://www.amazon.com/gp/wishlist/static-add?u=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F&t=Drug+Target+Review+%E2%80%93+Issue+3+2022','amazon','405935443'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-amazon essb-s-bgh-amazon essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network"><span class="essb_icon essb_icon_amazon"></span><span class="essb_network_name">Amazon</span></a></li><li class="essb_item essb_link_yahoomail nolightbox"> <a href="http://compose.mail.yahoo.com/?body=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F" title="Share on Yahoo Mail" onclick="essb.window('http://compose.mail.yahoo.com/?body=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F','yahoomail','405935443'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-yahoomail essb-s-bgh-yahoomail essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_yahoomail"></span><span class="essb_network_name">Yahoo Mail</span></a></li><li class="essb_item essb_link_gmail nolightbox"> <a href="https://mail.google.com/mail/u/0/?view=cm&fs=1&su=Drug+Target+Review+%E2%80%93+Issue+3+2022&body=In+this+issue+are+articles+on+engineered+bacteria%2C+how+smFRET+was+used+to+image+GPCRs+and+an+assay+to+identify+COVID-19+drugs. https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F&ui=2&tf=1" title="Share on Gmail" onclick="essb.window('https://mail.google.com/mail/u/0/?view=cm&fs=1&su=Drug+Target+Review+%E2%80%93+Issue+3+2022&body=In+this+issue+are+articles+on+engineered+bacteria%2C+how+smFRET+was+used+to+image+GPCRs+and+an+assay+to+identify+COVID-19+drugs. https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F&ui=2&tf=1','gmail','405935443'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-gmail essb-s-bgh-gmail essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_gmail"></span><span class="essb_network_name">Gmail</span></a></li><li class="essb_item essb_link_aol nolightbox"> <a href="http://webmail.aol.com/Mail/ComposeMessage.aspx?subject=Drug+Target+Review+%E2%80%93+Issue+3+2022&body=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F" title="Share on AOL" onclick="essb.window('http://webmail.aol.com/Mail/ComposeMessage.aspx?subject=Drug+Target+Review+%E2%80%93+Issue+3+2022&body=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F','aol','405935443'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-aol essb-s-bgh-aol essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_aol"></span><span class="essb_network_name">AOL</span></a></li><li class="essb_item essb_link_newsvine nolightbox"> <a href="http://www.newsvine.com/_tools/seed&save?u=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F&h=Drug+Target+Review+%E2%80%93+Issue+3+2022" title="Share on Newsvine" onclick="essb.window('http://www.newsvine.com/_tools/seed&save?u=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F&h=Drug+Target+Review+%E2%80%93+Issue+3+2022','newsvine','405935443'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-newsvine essb-s-bgh-newsvine essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_newsvine"></span><span class="essb_network_name">Newsvine</span></a></li><li class="essb_item essb_link_hackernews nolightbox"> <a href="https://news.ycombinator.com/submitlink?u=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F&t=Drug+Target+Review+%E2%80%93+Issue+3+2022" title="Share on HackerNews" onclick="essb.window('https://news.ycombinator.com/submitlink?u=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F&t=Drug+Target+Review+%E2%80%93+Issue+3+2022','hackernews','405935443'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-hackernews essb-s-bgh-hackernews essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_hackernews"></span><span class="essb_network_name">HackerNews</span></a></li><li class="essb_item essb_link_evernote nolightbox"> <a href="https://www.evernote.com/clip.action?url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F&title=Drug+Target+Review+%E2%80%93+Issue+3+2022" title="Share on Evernote" onclick="essb.window('http://www.evernote.com/clip.action?url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F&title=Drug+Target+Review+%E2%80%93+Issue+3+2022','evernote','405935443'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-evernote essb-s-bgh-evernote essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network"><span class="essb_icon essb_icon_evernote"></span><span class="essb_network_name">Evernote</span></a></li><li class="essb_item essb_link_myspace nolightbox"> <a href="https://myspace.com/post?u=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F" title="Share on MySpace" onclick="essb.window('https://myspace.com/post?u=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F','myspace','405935443'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-myspace essb-s-bgh-myspace essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_myspace"></span><span class="essb_network_name">MySpace</span></a></li><li class="essb_item essb_link_mailru nolightbox"> <a href="http://connect.mail.ru/share?url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F&title=Drug+Target+Review+%E2%80%93+Issue+3+2022&description=In+this+issue+are+articles+on+engineered+bacteria%2C+how+smFRET+was+used+to+image+GPCRs+and+an+assay+to+identify+COVID-19+drugs." title="Share on Mail.ru" onclick="essb.window('http://connect.mail.ru/share?url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F&title=Drug+Target+Review+%E2%80%93+Issue+3+2022&description=In+this+issue+are+articles+on+engineered+bacteria%2C+how+smFRET+was+used+to+image+GPCRs+and+an+assay+to+identify+COVID-19+drugs.','mailru','405935443'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-mailru essb-s-bgh-mailru essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_mailru"></span><span class="essb_network_name">Mail.ru</span></a></li><li class="essb_item essb_link_viadeo nolightbox"> <a href="https://www.viadeo.com/?url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F&title=Drug+Target+Review+%E2%80%93+Issue+3+2022" title="Share on Viadeo" onclick="essb.window('https://www.viadeo.com/?url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F&title=Drug+Target+Review+%E2%80%93+Issue+3+2022','viadeo','405935443'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-viadeo essb-s-bgh-viadeo essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_viadeo"></span><span class="essb_network_name">Viadeo</span></a></li><li class="essb_item essb_link_line nolightbox"> <a href="https://social-plugins.line.me/lineit/share?url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F" title="Share on Line" onclick="essb.tracking_only('', 'line', '405935443', true);" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-line essb-s-bgh-line essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_line"></span><span class="essb_network_name">Line</span></a></li><li class="essb_item essb_link_flipboard nolightbox"> <a href="https://share.flipboard.com/bookmarklet/popout?url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F&title=Drug+Target+Review+%E2%80%93+Issue+3+2022" title="Share on Flipboard" onclick="essb.window('https://share.flipboard.com/bookmarklet/popout?url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F&title=Drug+Target+Review+%E2%80%93+Issue+3+2022','flipboard','405935443'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-flipboard essb-s-bgh-flipboard essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_flipboard"></span><span class="essb_network_name">Flipboard</span></a></li><li class="essb_item essb_link_comments nolightbox"> <a href="#comments" title="Share on Comments" onclick="essb.tracking_only('', 'comments', '405935443', true);" target="_self" rel="nofollow" class="nolightbox essb-s-bg-comments essb-s-bgh-comments essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_comments"></span><span class="essb_network_name">Comments</span></a></li><li class="essb_item essb_link_yummly nolightbox"> <a href="http://www.yummly.com/urb/verify?url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F&title=Drug+Target+Review+%E2%80%93+Issue+3+2022&image=https://www.drugtargetreview.com/wp-content/uploads/DTR-Issue-3-Feature-750-x-500.jpg&yumtype=button" title="Share on Yummly" onclick="essb.window('http://www.yummly.com/urb/verify?url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F&title=Drug+Target+Review+%E2%80%93+Issue+3+2022&image=https://www.drugtargetreview.com/wp-content/uploads/DTR-Issue-3-Feature-750-x-500.jpg&yumtype=button','yummly','405935443'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-yummly essb-s-bgh-yummly essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_yummly"></span><span class="essb_network_name">Yummly</span></a></li><li class="essb_item essb_link_sms nolightbox"> <a href="sms:&body=Drug%20Target%20Review%20–%20Issue%203%202022%20https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F" title="Share on SMS" onclick="essb.sms('Drug%20Target%20Review%20–%20Issue%203%202022%20https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F', '405935443'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-sms essb-s-bgh-sms essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_sms"></span><span class="essb_network_name">SMS</span></a></li><li class="essb_item essb_link_viber nolightbox"> <a href="viber://forward?text=Drug%20Target%20Review%20–%20Issue%203%202022%20https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F" title="Share on Viber" onclick="essb.tracking_only('', 'viber', '405935443', true);" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-viber essb-s-bgh-viber essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_viber"></span><span class="essb_network_name">Viber</span></a></li><li class="essb_item essb_link_telegram nolightbox"> <a href="tg://msg?text=Drug%20Target%20Review%20–%20Issue%203%202022%20https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F" title="Share on Telegram" onclick="essb.tracking_only('', 'telegram', '405935443', true);" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-telegram essb-s-bgh-telegram essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_telegram"></span><span class="essb_network_name">Telegram</span></a></li><li class="essb_item essb_link_subscribe nolightbox"> <a href="#" title="Share on Subscribe" onclick="essb.toggle_subscribe('405935443'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-subscribe essb-s-bgh-subscribe essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_subscribe"></span><span class="essb_network_name">Subscribe</span></a></li><li class="essb_item essb_link_skype nolightbox"> <a href="https://web.skype.com/share?url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F" title="Share on Skype" onclick="essb.window('https://web.skype.com/share?url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F','skype','405935443'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-skype essb-s-bgh-skype essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_skype"></span><span class="essb_network_name">Skype</span></a></li><li class="essb_item essb_link_messenger nolightbox"> <a href="fb-messenger://share/?link=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F" title="Share on Facebook Messenger" onclick="essb.fbmessenger('', 'https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F', '405935443'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-messenger essb-s-bgh-messenger essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_messenger"></span><span class="essb_network_name">Facebook Messenger</span></a></li><li class="essb_item essb_link_kakaotalk nolightbox"> <a href="https://story.kakao.com/share?url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F" title="Share on Kakao" onclick="essb.window('https://story.kakao.com/share?url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F','kakaotalk','405935443'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-kakaotalk essb-s-bgh-kakaotalk essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_kakaotalk"></span><span class="essb_network_name">Kakao</span></a></li><li class="essb_item essb_link_livejournal nolightbox"> <a href="http://www.livejournal.com/update.bml?subject=Drug Target Review – Issue 3 2022&event=%3Ca+href%3D%22https%253A%252F%252Fwww.drugtargetreview.com%252Farticle%252F104912%252Fdrug-target-review-issue-3-2022%252F%22%3EDrug+Target+Review+%E2%80%93+Issue+3+2022%3C%2Fa%3E" title="Share on LiveJournal" onclick="essb.window('http://www.livejournal.com/update.bml?subject=Drug Target Review – Issue 3 2022&event=%3Ca+href%3D%22https%253A%252F%252Fwww.drugtargetreview.com%252Farticle%252F104912%252Fdrug-target-review-issue-3-2022%252F%22%3EDrug+Target+Review+%E2%80%93+Issue+3+2022%3C%2Fa%3E','livejournal','405935443'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-livejournal essb-s-bgh-livejournal essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_livejournal"></span><span class="essb_network_name">LiveJournal</span></a></li><li class="essb_item essb_link_yammer nolightbox"> <a href="https://www.yammer.com/messages/new?login=true&trk_event=yammer_share&status=Drug%20Target%20Review%20–%20Issue%203%202022 https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F" title="Share on Yammer" onclick="essb.window('https://www.yammer.com/messages/new?login=true&trk_event=yammer_share&status=Drug%20Target%20Review%20–%20Issue%203%202022 https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F','yammer','405935443'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-yammer essb-s-bgh-yammer essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_yammer"></span><span class="essb_network_name">Yammer</span></a></li><li class="essb_item essb_link_meetedgar nolightbox"> <a href="javascript:(function()%7B!function()%7Bvar e%3Ddocument.getElementsByTagName("head")%5B0%5D,t%3Ddocument.createElement("script")%3Bt.type%3D"text/javascript",t.src%3D"//app.meetedgar.com/share.js%3F"%2BMath.floor(99999*Math.random()),e.appendChild(t)%7D()%7D)()%3B" title="Share on Edgar" onclick="essb.tracking_only('', 'meetedgar', '405935443', true);" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-meetedgar essb-s-bgh-meetedgar essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_meetedgar"></span><span class="essb_network_name">Edgar</span></a></li><li class="essb_item essb_link_fintel nolightbox"> <a href="https://fintel.io/submit?url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F" title="Share on Fintel" onclick="essb.window('https://fintel.io/submit?url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F','fintel','405935443'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-fintel essb-s-bgh-fintel essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_fintel"></span><span class="essb_network_name">Fintel</span></a></li><li class="essb_item essb_link_mix nolightbox"> <a href="https://mix.com/add?url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F" title="Share on Mix" onclick="essb.window('https://mix.com/add?url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F','mix','405935443'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-mix essb-s-bgh-mix essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_mix"></span><span class="essb_network_name">Mix</span></a></li><li class="essb_item essb_link_instapaper nolightbox"> <a href="https://www.instapaper.com/hello2?url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F&title=Drug+Target+Review+%E2%80%93+Issue+3+2022&description=In+this+issue+are+articles+on+engineered+bacteria%2C+how+smFRET+was+used+to+image+GPCRs+and+an+assay+to+identify+COVID-19+drugs." title="Share on Instapaper" onclick="essb.window('https://www.instapaper.com/hello2?url=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F&title=Drug+Target+Review+%E2%80%93+Issue+3+2022&description=In+this+issue+are+articles+on+engineered+bacteria%2C+how+smFRET+was+used+to+image+GPCRs+and+an+assay+to+identify+COVID-19+drugs.','instapaper','405935443'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-instapaper essb-s-bgh-instapaper essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_instapaper"></span><span class="essb_network_name">Instapaper</span></a></li><li class="essb_item essb_link_copy nolightbox"> <a href="#" title="Share on Copy Link" onclick="essb.copy_link('405935443','https://www.drugtargetreview.com/article/104912/drug-target-review-issue-3-2022/'); return false;" target="_blank" rel="nofollow" class="nolightbox essb-s-bg-copy essb-s-bgh-copy essb-s-c-light essb-s-hover-effect essb-s-bg-network essb-s-bgh-network" ><span class="essb_icon essb_icon_copy"></span><span class="essb_network_name">Copy Link</span></a></li></ul></div></div></div> <div class="essb_morepopup_shadow essb_morepopup_shadow_1083901612" onclick="essb.toggle_less_popup('1083901612'); return false;"></div><div class="essb-subscribe-form essb-subscribe-form-405935443 essb-subscribe-form-popup" data-popup="1" style="display: none;"><div class="essb-subscribe-form-close" onclick="essb.subscribe_popup_close('405935443');"><i class="essb_svg_icon essb_svg_icon_close"><svg class="essb-svg-icon" aria-hidden="true" role="img" focusable="false" height="32" viewBox="0 0 32 32" width="32" xmlns="http://www.w3.org/2000/svg"><path d="M32,25.7c0,0.7-0.3,1.3-0.8,1.8l-3.7,3.7c-0.5,0.5-1.1,0.8-1.9,0.8c-0.7,0-1.3-0.3-1.8-0.8L16,23.3l-7.9,7.9C7.6,31.7,7,32,6.3,32c-0.8,0-1.4-0.3-1.9-0.8l-3.7-3.7C0.3,27.1,0,26.4,0,25.7c0-0.8,0.3-1.3,0.8-1.9L8.7,16L0.8,8C0.3,7.6,0,6.9,0,6.3c0-0.8,0.3-1.3,0.8-1.9l3.7-3.6C4.9,0.2,5.6,0,6.3,0C7,0,7.6,0.2,8.1,0.8L16,8.7l7.9-7.9C24.4,0.2,25,0,25.7,0c0.8,0,1.4,0.2,1.9,0.8l3.7,3.6C31.7,4.9,32,5.5,32,6.3c0,0.7-0.3,1.3-0.8,1.8L23.3,16l7.9,7.9C31.7,24.4,32,25,32,25.7z" /></svg></i></div></div><div class="essb-subscribe-form-overlay essb-subscribe-form-overlay-405935443" onclick="essb.subscribe_popup_close('405935443');"></div> </div> </div> <div class="excerpt"><p>In this issue are articles on synthetically engineered bacteria to deliver therapeutics, how single-molecule fluorescence resonance energy transfer was used to image GPCRs and a new assay to identify coronavirus drugs. Also included are pieces on vaccine development, monoclonal antibodies and neuroscience.</p> </div> <p>Included in this issue: </p> <ul> <li><strong>SYNTHETIC BIOLOGY <br /> </strong><strong>Synthetic biology is ready for the therapeutic limelight<br /> </strong>Dr Dan Mandell, GRO Biosciences</li> <li><strong style="font-family: Muli, Arial, sans-serif;">TARGETS<br /> </strong><strong style="font-family: Muli, Arial, sans-serif;">Insights into GPCRs via innovative imaging<br /> </strong><span style="font-family: Muli, Arial, sans-serif;">Dr Jonathan Javitch, </span>Columbia University</li> <li><strong>ANTIBODIES<br /> </strong><strong>T-cell redirecting bispecific antibodies: the next era of immune-based therapies for multiple myeloma?<br /> </strong>Dr Edmond Chan, Janssen</li> <li><strong>COVID-19<br /> </strong><strong>In search of COVID-19 antibodies<br /> </strong>Ria Kakkad, <em>Drug Target Review</em></li> <li><strong>ASSAYS<br /> </strong><strong>Building a powerful portfolio of sepsis biomarker signatures for therapeutic clinical trials<br /> </strong>Dr Rolland Carlson and Dr Richard Brandon, Immunexpress</li> <li><strong>VACCINE DEVELOPMENT<br /> </strong><strong>Advancing vaccines with extracellular vesicles<br /> </strong>Dr Christopher Locher, Versatope Therapeutics</li> <li><strong>NEUROSCIENCE<br /> </strong><strong>Right model, right complexity: using <em>in vitro</em> human disease cell models in drug discovery<br /> </strong>Dr Beth Hoffman, Origami Therapeutics</li> </ul> </article> </main> </div> </div> <aside id="right"> <div class="cpt zform-hide-later"><span>Download</span></div> <script data-cfasync="false" src="/cdn-cgi/scripts/5c5dd728/cloudflare-static/email-decode.min.js"></script><script type="text/javascript">window.ajaxurl = "https://www.drugtargetreview.com/wp-admin/admin-ajax.php";window.zmember_base_url = "https://www.drugtargetreview.com/zmember";window.zform_do_user_lookup = false;window.zform_lead_data = JSON.parse('{"zform_post_id":104916,"post_id":104912,"lead_name":"Drug Target Review - Issue #3 2022","lead_form_type":"Redirect","workbooks_event_id":"2422","workbooks_campaign_reference":"CAMP-20717","thanks_url":"https:\/\/edition.pagesuite.com\/html5\/reader\/production\/default.aspx?pubname=&edid=694163a4-97e0-462d-8e04-38365533ea76","additional_questions":[],"additional_questions_conditional":true,"wba":"ZGE1a3RDSmJhZjh3YzVTd29ta1BZdmtQVVpKbEJYYTdzQXhSVmJWSUM5VStjdkVVOTNvTTdnPT0=","brand_code":"DTR","lead_type":"Reader","campaign_source":"","success_url":"http:\/\/localhost:8082\/form\/success","failure_url":"http:\/\/localhost:8082\/form\/failure","topics":"","captcha_enabled":true,"skip_registration":false,"require_digital_subs":true,"has_sponsors":true,"sponsor_count":1,"auto_optin":false,"enabled_emails":["1","2","4","5"]}');window.zform_site_data = JSON.parse('{"areas_of_interest":{"analysis":"Analysis","assays":"Assays","biomarkers":"Biomarkers","clinical_trials":"Clinical Trials","drug_discovery_processes":"Drug Discovery Processes","genomics":"Genomics","hit_to_lead":"Hit-to-Lead","imaging":"Imaging","informatics":"Informatics","lab_automation":"Lab Automation","molecular_diagnostics":"Molecular Diagnostics (MDX)","personalised_medicine":"Personalised Medicine","screening":"Screening","sequencing":"Sequencing","stem_cells":"Stem Cells","targets":"Targets","translational_medicine":"Translational Science"},"email_preferences":{"1":"Newsletter: News, articles and analysis by email","2":"Third party: Application notes, product developments and updates from our trusted partners by email","4":"Webinar: Information about webinars by email","5":"Event: Information about events by email"},"secondary_interests":{"1":"Cardiovascular Disease","2":"Immunology","3":"Infectious Disease","4":"Inflammation","5":"Metabolic Disease","6":"Microbiome Research","7":"Musculoskeletal Disease","8":"Neuroscience","9":"Oncology","10":"Ophthalmology","11":"Rare Diseases","12":"Renal Disorders","13":"Respiratory Disease","14":"COVID"},"secondary_label":"Therapeutic interests","titles":{"Mr":"Mr","Dr":"Dr","Miss":"Miss","Mrs":"Mrs","Ms":"Ms","Other":"Other"},"vatnum_countries":[14,22,24,98,54,55,58,63,70,75,56,89,100,102,110,135,133,134,152,165,178,183,188,201,199,67,196,77,166,43]}');</script> <div id="zform-app" v-cloak> <data-loader-component></data-loader-component> <h3 class="zform-hide-later">Download Issue #3 2022</h3> <p class="zform-hide-later"></p> <div v-if="current_page == 'unlogged'"> <p> To download Issue #3 2022 please login or create an account. If you choose to create an account you'll gain access to our website content, as well as the opportunity to subscribe free-of-charge to Drug Target Review's magazine and email communications. </p> <button @click="changePage('login')" class="button">Login</button> <button @click="changePage('step1')" class="button">Create an account</button> </div> <div v-if="current_page == 'wantcreate'"> <p>Do you want to create an account?</p> <button class="button" @click="changePage('step1')">Yes</button> <button class="button" @click="changePage('step7')">No</button> </div> <login-component inline-template v-if="current_page == 'login'"> <div id="zform=login"> <h3>Login</h3> <p>Enter your email and password for Drug Target Review below.</p> <p><label for="email">Email address</label> <input type="email" name="email" v-model="user.email"></p> <p><label for="password">Password</label> <input type="password" name="password" v-model="user.password"></p> <p><a class="forgot" href="https://www.drugtargetreview.com/zmember/subscribers/getpassword?lasturl=https%3A%2F%2Fwww.drugtargetreview.com%2Farticle%2F104912%2Fdrug-target-review-issue-3-2022%2F">I've forgotten my password</a></p> <p><button class="button" @click.prevent="changePage('step1')">I don't have an account</button> <input class="inline" :class="buttonClass" type="submit" :value="busy.login ? 'Working...' : 'Continue'" id="zform-login-button" @click.prevent="login" :disabled="busy.login"> </p> </div> </login-component> <form method="post" action="https://www.drugtargetreview.com/zmember/zform/leads_submit" id="zform-main-form" novalidate> <input type="hidden" name="thanks_url" value="https://edition.pagesuite.com/html5/reader/production/default.aspx?pubname=&edid=694163a4-97e0-462d-8e04-38365533ea76"> <input type="hidden" name="form_url" value="https://www.drugtargetreview.com/article/104912/drug-target-review-issue-3-2022/"> <input type="hidden" name="post_id" value="104912" /> <input type="hidden" name="zform_post_id" value="104916" /> <input type="hidden" name="lead[lead_type]" value="Reader" /> <input type="hidden" name="lead[campaign_source]" value="" /> <input type="hidden" name="lead[brand_code]" value="DTR" /> <input type="hidden" name="lead[workbooks_event_id]" value="2422"> <input type="hidden" name="lead[workbooks_campaign_reference]" value="CAMP-20717"> <input type="hidden" name="lead[lead_name]" value="Drug Target Review - Issue #3 2022"> <input type="hidden" name="lead[success_url]" value="http://localhost:8082/form/success"> <input type="hidden" name="lead[failure_url]" value="http://localhost:8082/form/failure"> <input type="hidden" name="lead[wba]" value="ZGE1a3RDSmJhZjh3YzVTd29ta1BZdmtQVVpKbEJYYTdzQXhSVmJWSUM5VStjdkVVOTNvTTdnPT0="> <step1-component inline-template v-show="current_page == 'step1'"> <div> <h4>Step 1 - Download Issue #3 2022</h4> <p>Please enter your email and choose a password for your account. Passwords must include at least 8 characters, a mixture of both uppercase and lowercase letters, at least one letter and number and at least one special character, e.g. ! @ # ? ]</p> <p><label for="email">Email address</label> <input type="text" v-model="account_details.email" name="email"><span class="error">{{errors.email}}</span></p> <p><label for="password">Password</label> <input type="password" v-model="account_details.password" name="password"><span class="error">{{errors.password}}</span></p> <p><label for="confirm_password">Confirm password</label> <input type="password" v-model="account_details.confirm_password" name="confirm_password"><span class="error">{{errors.confirm_password}}</span></p> <p><span class="error">{{errors.general}}</span></p> <button class="button" @click.prevent="changePage('login')">Back</button> <button class="button brandColour" :class="buttonClass" @click.prevent="submit">Continue</button> </div> </step1-component> <step2-component inline-template v-show="current_page == 'step2'"> <div> <h4>Step 2 - Subscription preferences</h4> <p>Please select whether you would like to receive Drug Target Review journal in printed and/or digital form, and choose which types of email communication you would like to receive.</p> <p>Check all that apply:</p> <ul class="checkboxes"> <li><input type="checkbox" v-model="selectAllValue" @change="selectAll"><label for="">Select all</label></li> </ul> <div v-if="showPrinted"> <ul class="checkboxes"> <li><input type="checkbox" value="1" name="zform[sub_printed]" v-model="confirmation.sub_free_print"><label>Printed version of Drug Target Review journal (Sent free-of-charge by post 4 times a year)</label></li> </ul> </div> <div v-if="showDigital"> <ul class="checkboxes"> <li><input type="checkbox" value="1" name="zform[sub_online]" v-model="confirmation.sub_free_digital"><label>Digital version of the Drug Target Review journal (Sent free-of-charge via email 4 times a year)</label></li> </ul> </div> <template v-for="(v, k) in site_data.email_preferences"> <div v-if="showEmailOption(k)"> <ul class="checkboxes"> <li><input type="checkbox" :value="k" v-model="confirmation.email_preferences"><label>{{v}}</label></li> </ul> </div> </template> <button @click.prevent="advancePage" :disabled="busy.save">{{busy.save ? 'Saving...' : (digitalSubsError ? 'You must subscribe to the online edition to proceed' : 'Next')}}</button> </div> </step2-component> <step3-component inline-template v-show="current_page == 'step3'"> <div> <h4>Step 3 - Personal details</h4> <p>Please enter your personal details.</p> <div id="zform-details"> <p><label for="title">Title</label> <validator required :value="user_data.title" ident="title" @validation-status="checkValidation"> <select v-model="user_data.title"> <option :value="null">- select - </option> <option :value="title" v-for="(v, title) in site_data.titles" :key="title">{{title}}</option> </select> </validator> </p> <div v-show="showTitleOther"> <p><label for="title_other">Title other</label> <validator :required-if="user_data.title" :required-if-val="'Other'" minlength="2" :value="user_data.title_other" ident="title_other" @validation-status="checkValidation"> <input type="text" name="title_other" v-model="user_data.title_other"> </validator> </p> </div> <p><label for="name">First name</label> <validator required minlength="2" :value="user_data.name" ident="name" @validation-status="checkValidation"> <input type="text" name="name" v-model="user_data.name"> </validator> </p> <p><label for="surname">Last name</label> <validator required minlength="2" :value="user_data.surname" ident="surname" @validation-status="checkValidation"> <input type="text" name="surname" v-model="user_data.surname"> </validator> </p> <p><label for="job_title">Job title</label> <validator required minlength="2" :value="user_data.contact_job_title" ident="contact_job_title" @validation-status="checkValidation"> <input type="text" name="job_title" v-model="user_data.contact_job_title"> </validator> </p> <p><label for="company">Your employer</label> <validator required minlength="2" :value="user_data.contact_company_name" ident="contact_company_name" @validation-status="checkValidation"> <input type="text" name="company" v-model="user_data.contact_company_name"> </validator> </p> <p><label for="phone">Telephone</label> <validator required minlength="6" :value="user_data.contact_phone" ident="contact_phone" @validation-status="checkValidation"> <input type="text" name="phone" v-model="user_data.contact_phone"> </validator> </p> </div> <button class="button" @click.prevent="changePage('step2')">Previous</button> <button class="button brandColour" @click.prevent="advancePage" :disabled="!formComplete || busy.save">{{!formComplete ? 'Please complete all of the fields' : busy.save ? 'Saving...' : 'Next'}}</button> </div> </step3-component> <step4-component inline-template v-show="current_page == 'step4'"> <div> <h4>Step 4 - Location details</h4> <p>Please enter your location details. We may use these details to personalise the content you see.</p> <div v-if="form_data.confirmation.sub_free_print"> <p><label for="address">Address 1</label> <validator required minlength="2" :value="address.contact_address" ident="contact_address" @validation-status="checkValidation"> <input type="text" name="address" v-model="address.contact_address"> </validator></p> </div> <div v-if="form_data.confirmation.sub_free_print"> <p><label for="address">Address 2</label> <input type="text" name="address2" v-model="address.contact_address2"> </p> </div> <p><label for="city">Town/City</label> <validator required minlength="2" maxlength="100" :value="address.contact_city" ident="contact_city" @validation-status="checkValidation"> <input type="text" name="city" v-model="address.contact_city"> </validator></p> <div v-if="form_data.confirmation.sub_free_print"> <p><label for="postal_code">Zip/Post code</label> <validator required :minlength="postalMinLength" :maxlength="postalMaxLength":value="address.contact_postal_code" ident="contact_postal_code" @validation-status="checkValidation"> <input type="text" name="postal_code" v-model="address.contact_postal_code"> </validator></p> </div> <p><label for="country">Country</label> <validator required :value="address.contact_country_id" ident="contact_country_id" @validation-status="checkValidation"> <select name="country" class="form-dropdown" v-model="address.contact_country_id" @change="resetState"> <option :value="null">- select country -</option> <option value="3" >Afghanistan</option> <option value="17" >Aland Islands</option> <option value="6" >Albania</option> <option value="61" >Algeria</option> <option value="13" >American Samoa</option> <option value="1" >Andorra</option> <option value="9" >Angola</option> <option value="5" >Anguilla</option> <option value="11" >Antarctica</option> <option value="4" >Antigua and Barbuda</option> <option value="12" >Argentina</option> <option value="7" >Armenia</option> <option value="16" >Aruba</option> <option value="10" >Asia/Pacific Region</option> <option value="15" >Australia</option> <option value="14" >Austria</option> <option value="18" >Azerbaijan</option> <option value="32" >Bahamas</option> <option value="25" >Bahrain</option> <option value="21" >Bangladesh</option> <option value="20" >Barbados</option> <option value="36" >Belarus</option> <option value="22" >Belgium</option> <option value="37" >Belize</option> <option value="27" >Benin</option> <option value="28" >Bermuda</option> <option value="33" >Bhutan</option> <option value="30" >Bolivia</option> <option value="19" >Bosnia and Herzegovina</option> <option value="35" >Botswana</option> <option value="34" >Bouvet Island</option> <option value="31" >Brazil</option> <option value="106" >British Indian Ocean Territory</option> <option value="29" >Brunei Darussalam</option> <option value="24" >Bulgaria</option> <option value="23" >Burkina Faso</option> <option value="26" >Burundi</option> <option value="117" >Cambodia</option> <option value="47" >Cameroon</option> <option value="38" >Canada</option> <option value="52" >Cape Verde</option> <option value="124" >Cayman Islands</option> <option value="41" >Central African Republic</option> <option value="212" >Chad</option> <option value="46" >Chile</option> <option value="48" >China</option> <option value="53" >Christmas Island</option> <option value="39" >Cocos (Keeling) Islands</option> <option value="49" >Colombia</option> <option value="119" >Comoros</option> <option value="42" >Congo</option> <option value="40" >Congo, The Democratic Republic of the</option> <option value="45" >Cook Islands</option> <option value="50" >Costa Rica</option> <option value="44" >Cote d'Ivoire</option> <option value="98" >Croatia</option> <option value="51" >Cuba</option> <option value="54" >Cyprus</option> <option value="55" >Czechia</option> <option value="58" >Denmark</option> <option value="57" >Djibouti</option> <option value="59" >Dominica</option> <option value="60" >Dominican Republic</option> <option value="62" >Ecuador</option> <option value="64" >Egypt</option> <option value="208" >El Salvador</option> <option value="88" >Equatorial Guinea</option> <option value="66" >Eritrea</option> <option value="63" >Estonia</option> <option value="68" >Ethiopia</option> <option value="69" >Europe</option> <option value="72" >Falkland Islands (Malvinas)</option> <option value="74" >Faroe Islands</option> <option value="71" >Fiji</option> <option value="70" >Finland</option> <option value="75" >France</option> <option value="80" >French Guiana</option> <option value="174" >French Polynesia</option> <option value="213" >French Southern Territories</option> <option value="76" >Gabon</option> <option value="85" >Gambia</option> <option value="79" >Georgia</option> <option value="56" >Germany</option> <option value="82" >Ghana</option> <option value="83" >Gibraltar</option> <option value="89" >Greece</option> <option value="84" >Greenland</option> <option value="78" >Grenada</option> <option value="87" >Guadeloupe</option> <option value="92" >Guam</option> <option value="91" >Guatemala</option> <option value="81" >Guernsey</option> <option value="86" >Guinea</option> <option value="93" >Guinea-Bissau</option> <option value="94" >Guyana</option> <option value="99" >Haiti</option> <option value="96" >Heard Island and McDonald Islands</option> <option value="233" >Holy See (Vatican City State)</option> <option value="97" >Honduras</option> <option value="95" >Hong Kong</option> <option value="100" >Hungary</option> <option value="109" >Iceland</option> <option value="105" >India</option> <option value="101" >Indonesia</option> <option value="108" >Iran, Islamic Republic of</option> <option value="107" >Iraq</option> <option value="102" >Ireland</option> <option value="104" >Isle of Man</option> <option value="103" >Israel</option> <option value="110" >Italy</option> <option value="112" >Jamaica</option> <option value="114" >Japan</option> <option value="111" >Jersey</option> <option value="113" >Jordan</option> <option value="125" >Kazakhstan</option> <option value="115" >Kenya</option> <option value="118" >Kiribati</option> <option value="121" >Korea, Democratic People's Republic of</option> <option value="122" >Korea, Republic of</option> <option value="123" >Kuwait</option> <option value="116" >Kyrgyzstan</option> <option value="126" >Lao People's Democratic Republic</option> <option value="135" >Latvia</option> <option value="127" >Lebanon</option> <option value="132" >Lesotho</option> <option value="131" >Liberia</option> <option value="136" >Libyan Arab Jamahiriya</option> <option value="129" >Liechtenstein</option> <option value="133" >Lithuania</option> <option value="134" >Luxembourg</option> <option value="147" >Macao</option> <option value="143" >Macedonia</option> <option value="141" >Madagascar</option> <option value="155" >Malawi</option> <option value="157" >Malaysia</option> <option value="154" >Maldives</option> <option value="144" >Mali</option> <option value="152" >Malta</option> <option value="142" >Marshall Islands</option> <option value="149" >Martinique</option> <option value="150" >Mauritania</option> <option value="153" >Mauritius</option> <option value="243" >Mayotte</option> <option value="156" >Mexico</option> <option value="73" >Micronesia, Federated States of</option> <option value="139" >Moldova, Republic of</option> <option value="138" >Monaco</option> <option value="146" >Mongolia</option> <option value="140" >Montenegro</option> <option value="151" >Montserrat</option> <option value="137" >Morocco</option> <option value="158" >Mozambique</option> <option value="145" >Myanmar</option> <option value="159" >Namibia</option> <option value="168" >Nauru</option> <option value="167" >Nepal</option> <option value="165" >Netherlands</option> <option value="8" >Netherlands Antilles</option> <option value="160" >New Caledonia</option> <option value="170" >New Zealand</option> <option value="164" >Nicaragua</option> <option value="161" >Niger</option> <option value="163" >Nigeria</option> <option value="169" >Niue</option> <option value="162" >Norfolk Island</option> <option value="148" >Northern Mariana Islands</option> <option value="166" >Norway</option> <option value="0" >Not selected</option> <option value="171" >Oman</option> <option value="177" >Pakistan</option> <option value="184" >Palau</option> <option value="182" >Palestinian Territory</option> <option value="172" >Panama</option> <option value="175" >Papua New Guinea</option> <option value="185" >Paraguay</option> <option value="173" >Peru</option> <option value="176" >Philippines</option> <option value="180" >Pitcairn</option> <option value="178" >Poland</option> <option value="183" >Portugal</option> <option value="181" >Puerto Rico</option> <option value="186" >Qatar</option> <option value="187" >Reunion</option> <option value="188" >Romania</option> <option value="190" >Russian Federation</option> <option value="191" >Rwanda</option> <option value="198" >Saint Helena</option> <option value="120" >Saint Kitts and Nevis</option> <option value="128" >Saint Lucia</option> <option value="179" >Saint Pierre and Miquelon</option> <option value="234" >Saint Vincent and the Grenadines</option> <option value="241" >Samoa</option> <option value="203" >San Marino</option> <option value="207" >Sao Tome and Principe</option> <option value="192" >Saudi Arabia</option> <option value="204" >Senegal</option> <option value="189" >Serbia</option> <option value="194" >Seychelles</option> <option value="202" >Sierra Leone</option> <option value="197" >Singapore</option> <option value="201" >Slovakia</option> <option value="199" >Slovenia</option> <option value="193" >Solomon Islands</option> <option value="205" >Somalia</option> <option value="244" >South Africa</option> <option value="90" >South Georgia and the South Sandwich Islands</option> <option value="67" >Spain</option> <option value="130" >Sri Lanka</option> <option value="195" >Sudan</option> <option value="206" >Suriname</option> <option value="200" >Svalbard and Jan Mayen</option> <option value="210" >Swaziland</option> <option value="196" >Sweden</option> <option value="43" >Switzerland</option> <option value="209" >Syrian Arab Republic</option> <option value="225" >Taiwan</option> <option value="216" >Tajikistan</option> <option value="226" >Tanzania, United Republic of</option> <option value="215" >Thailand</option> <option value="218" >Timor-Leste</option> <option value="214" >Togo</option> <option value="217" >Tokelau</option> <option value="221" >Tonga</option> <option value="223" >Trinidad and Tobago</option> <option value="220" >Tunisia</option> <option value="222" >Turkey</option> <option value="219" >Turkmenistan</option> <option value="211" >Turks and Caicos Islands</option> <option value="224" >Tuvalu</option> <option value="228" >Uganda</option> <option value="227" >Ukraine</option> <option value="2" >United Arab Emirates</option> <option value="77" >United Kingdom</option> <option value="229" >United States Minor Outlying Islands</option> <option value="230" >United States of America</option> <option value="231" >Uruguay</option> <option value="232" >Uzbekistan</option> <option value="239" >Vanuatu</option> <option value="235" >Venezuela</option> <option value="238" >Vietnam</option> <option value="236" >Virgin Islands, British</option> <option value="237" >Virgin Islands, U.S.</option> <option value="240" >Wallis and Futuna</option> <option value="65" >Western Sahara</option> <option value="242" >Yemen</option> <option value="245" >Zambia</option> <option value="246" >Zimbabwe</option> </select> </validator></p> <template v-if="address.contact_country_id === '230'"> <p><label for="us_ca_state">State</label> <validator required :value="address.contact_county" ident="contact_state_code_us" @validation-status="checkValidation" :key="'contact_state_us'"> <select name="us_ca_state" class="form-dropdown" v-model="address.contact_county"> <option :value="null">- select state -</option> <option value="AA">AA</option> <option value="AE">AE</option> <option value="AK">AK</option> <option value="AL">AL</option> <option value="AP">AP</option> <option value="AR">AR</option> <option value="AZ">AZ</option> <option value="CA">CA</option> <option value="CO">CO</option> <option value="CT">CT</option> <option value="DC ">DC </option> <option value="DE">DE</option> <option value="FL">FL</option> <option value="GA">GA</option> <option value="GU">GU</option> <option value="HI">HI</option> <option value="IA">IA</option> <option value="ID">ID</option> <option value="IL">IL</option> <option value="IN">IN</option> <option value="KS">KS</option> <option value="KY">KY</option> <option value="LA">LA</option> <option value="MA">MA</option> <option value="MD">MD</option> <option value="ME">ME</option> <option value="MI">MI</option> <option value="MN">MN</option> <option value="MO">MO</option> <option value="MS">MS</option> <option value="MT">MT</option> <option value="NC">NC</option> <option value="ND">ND</option> <option value="NE">NE</option> <option value="NH">NH</option> <option value="NJ">NJ</option> <option value="NM">NM</option> <option value="NV">NV</option> <option value="NY">NY</option> <option value="OH">OH</option> <option value="OK">OK</option> <option value="OR">OR</option> <option value="PA">PA</option> <option value="PR">PR</option> <option value="RI">RI</option> <option value="SC">SC</option> <option value="SD">SD</option> <option value="TN">TN</option> <option value="TX">TX</option> <option value="UT">UT</option> <option value="VA">VA</option> <option value="VI">VI</option> <option value="VT">VT</option> <option value="WA">WA</option> <option value="WI">WI</option> <option value="WV">WV</option> <option value="WY">WY</option> </select> </validator></p> </template> <template v-if="address.contact_country_id === '38'"> <p><label for="us_ca_state">State</label> <validator required :value="address.contact_county" ident="contact_state_code_ca" @validation-status="checkValidation" :key="'contact_state_ca'"> <select name="us_ca_state" class="form-dropdown" v-model="address.contact_county"> <option :value="null">- select state -</option> <option value="AB">AB</option> <option value="BC">BC</option> <option value="MB">MB</option> <option value="NB">NB</option> <option value="NL">NL</option> <option value="NS">NS</option> <option value="NT">NT</option> <option value="NU">NU</option> <option value="ON">ON</option> <option value="PE">PE</option> <option value="QC">QC</option> <option value="SK">SK</option> <option value="YT">YT</option> </select> </validator></p> </template> <template v-if="address.contact_country_id !== '230' && address.contact_country_id !== '38'"> <p><label for="county" >State/Province/Region</label> <validator required minlength="2" maxlength="100" :value="address.contact_county" ident="contact_county" @validation-status="checkValidation" :key="'contact_county'"> <input type="text" name="county" v-model="address.contact_county"> </validator></p> </template> <button class="button" @click.prevent="changePage('step3')">Previous</button> <button class="button brandColour" @click.prevent="advancePage" :disabled="!formComplete || busy.save">{{!formComplete ? 'Please complete all of the fields' : busy.save ? 'Saving...' : 'Next'}}</button> </div> </step4-component> <step5-component inline-template v-show="current_page == 'step5'"> <div> <h4>Step 5 - Areas of interest</h4> <p>Please select your areas of interest. We may use these details to personalise the content you see.</p> <p>Tick all that apply:</p> <ul class="checkboxes"> <li><input type="checkbox" v-model="select_all"><label>Select all</label></li> <template v-for="(v, k) in site_data.areas_of_interest"> <li><input type="checkbox" :value="k" v-model="areas_of_interest"><label>{{v}}</label></li> </template> </ul> <button class="button" @click.prevent="changePage('terms')">Previous</button> <button class="button brandColour" @click.prevent="advancePage" :disabled="!formComplete || busy.save">{{!formComplete ? 'Please select at least one area of interest' : busy.save ? 'Saving...' : 'Next'}}</button> </div> </step5-component> <step6-component inline-template v-show="current_page == 'step6'"> <div> <h4>Step 6 - Therapeutic areas of interest</h4> <p>Please select the therapeutic areas you are interested in. We may use these details to personalise the content you see.</p> <h5>{{site_data.secondary_label}}</h5> <p>Tick all that apply:</p> <ul class="checkboxes"> <li><input type="checkbox" v-model="select_all"><label>Select all</label></li> <template v-for="(v, k) in site_data.secondary_interests"> <li><input type="checkbox" :value="k" v-model="secondary_interests.interests"><label>{{v}}</label></li> </template> </ul> <p> <input type="text" v-model="secondary_interests.other" v-if="showOther" placeholder="Please specify"> </p> <button class="button" @click.prevent="changePage('step5')">Previous</button> <button class="button brandColour" @click.prevent="advancePage" :disabled="!formComplete || busy.save">{{!formComplete ? 'Please select at least one area of interest' : busy.save ? 'Saving...' : 'Next'}}</button> </div> </step6-component> <step7-component inline-template v-show="current_page == 'step7'"> <div id="zform-details"> <template v-if="!logged_in || lead_data.skip_registration"> <fieldset> <p><label for="name">First name</label> <validator required minlength="2" :value="main_form.contact_name" ident="contact_name" @validation-status="checkValidation"> <input type="text" name="name" v-model="main_form.contact_name"> </validator></p> <p><label for="surname">Last name</label> <validator required minlength="2" :value="main_form.contact_surname" ident="contact_surname" @validation-status="checkValidation"> <input type="text" name="surname" v-model="main_form.contact_surname"> </validator></p> <p><label for="email">Email address</label> <validator required :value="main_form.email" ident="email" @validation-status="checkValidation" validate-type="email"> <input type="email" name="email" v-model="main_form.email"> </validator></p> <p><label for="phone">Telephone</label> <validator required minlength="6" :value="main_form.contact_phone" ident="contact_phone" @validation-status="checkValidation"> <input type="text" name="phone" v-model="main_form.contact_phone"> </validator></p> <p><label for="job_title">Job title</label> <validator required minlength="2" maxlength="100" :value="main_form.contact_job_title" ident="contact_job_title" @validation-status="checkValidation"> <input type="text" name="job_title" v-model="main_form.contact_job_title"> </validator></p> <p><label for="company">Your employer</label> <validator required minlength="2" maxlength="100" :value="main_form.contact_company_name" ident="contact_company_name" @validation-status="checkValidation"> <input type="text" name="company" v-model="main_form.contact_company_name"> </validator></p> <p><label for="city">Town/City</label> <validator required minlength="2" maxlength="100" :value="main_form.contact_city" ident="contact_city" @validation-status="checkValidation"> <input type="text" name="city" v-model="main_form.contact_city"> </validator></p> <p><label for="country">Country</label> <validator required :value="main_form.contact_country_id" ident="contact_country_id" @validation-status="checkValidation"> <select name="country" class="form-dropdown" v-model="main_form.contact_country_id" @change="resetState"> <option :value="null">- select country -</option> <option value="3" >Afghanistan</option> <option value="17" >Aland Islands</option> <option value="6" >Albania</option> <option value="61" >Algeria</option> <option value="13" >American Samoa</option> <option value="1" >Andorra</option> <option value="9" >Angola</option> <option value="5" >Anguilla</option> <option value="11" >Antarctica</option> <option value="4" >Antigua and Barbuda</option> <option value="12" >Argentina</option> <option value="7" >Armenia</option> <option value="16" >Aruba</option> <option value="10" >Asia/Pacific Region</option> <option value="15" >Australia</option> <option value="14" >Austria</option> <option value="18" >Azerbaijan</option> <option value="32" >Bahamas</option> <option value="25" >Bahrain</option> <option value="21" >Bangladesh</option> <option value="20" >Barbados</option> <option value="36" >Belarus</option> <option value="22" >Belgium</option> <option value="37" >Belize</option> <option value="27" >Benin</option> <option value="28" >Bermuda</option> <option value="33" >Bhutan</option> <option value="30" >Bolivia</option> <option value="19" >Bosnia and Herzegovina</option> <option value="35" >Botswana</option> <option value="34" >Bouvet Island</option> <option value="31" >Brazil</option> <option value="106" >British Indian Ocean Territory</option> <option value="29" >Brunei Darussalam</option> <option value="24" >Bulgaria</option> <option value="23" >Burkina Faso</option> <option value="26" >Burundi</option> <option value="117" >Cambodia</option> <option value="47" >Cameroon</option> <option value="38" >Canada</option> <option value="52" >Cape Verde</option> <option value="124" >Cayman Islands</option> <option value="41" >Central African Republic</option> <option value="212" >Chad</option> <option value="46" >Chile</option> <option value="48" >China</option> <option value="53" >Christmas Island</option> <option value="39" >Cocos (Keeling) Islands</option> <option value="49" >Colombia</option> <option value="119" >Comoros</option> <option value="42" >Congo</option> <option value="40" >Congo, The Democratic Republic of the</option> <option value="45" >Cook Islands</option> <option value="50" >Costa Rica</option> <option value="44" >Cote d'Ivoire</option> <option value="98" >Croatia</option> <option value="51" >Cuba</option> <option value="54" >Cyprus</option> <option value="55" >Czechia</option> <option value="58" >Denmark</option> <option value="57" >Djibouti</option> <option value="59" >Dominica</option> <option value="60" >Dominican Republic</option> <option value="62" >Ecuador</option> <option value="64" >Egypt</option> <option value="208" >El Salvador</option> <option value="88" >Equatorial Guinea</option> <option value="66" >Eritrea</option> <option value="63" >Estonia</option> <option value="68" >Ethiopia</option> <option value="69" >Europe</option> <option value="72" >Falkland Islands (Malvinas)</option> <option value="74" >Faroe Islands</option> <option value="71" >Fiji</option> <option value="70" >Finland</option> <option value="75" >France</option> <option value="80" >French Guiana</option> <option value="174" >French Polynesia</option> <option value="213" >French Southern Territories</option> <option value="76" >Gabon</option> <option value="85" >Gambia</option> <option value="79" >Georgia</option> <option value="56" >Germany</option> <option value="82" >Ghana</option> <option value="83" >Gibraltar</option> <option value="89" >Greece</option> <option value="84" >Greenland</option> <option value="78" >Grenada</option> <option value="87" >Guadeloupe</option> <option value="92" >Guam</option> <option value="91" >Guatemala</option> <option value="81" >Guernsey</option> <option value="86" >Guinea</option> <option value="93" >Guinea-Bissau</option> <option value="94" >Guyana</option> <option value="99" >Haiti</option> <option value="96" >Heard Island and McDonald Islands</option> <option value="233" >Holy See (Vatican City State)</option> <option value="97" >Honduras</option> <option value="95" >Hong Kong</option> <option value="100" >Hungary</option> <option value="109" >Iceland</option> <option value="105" >India</option> <option value="101" >Indonesia</option> <option value="108" >Iran, Islamic Republic of</option> <option value="107" >Iraq</option> <option value="102" >Ireland</option> <option value="104" >Isle of Man</option> <option value="103" >Israel</option> <option value="110" >Italy</option> <option value="112" >Jamaica</option> <option value="114" >Japan</option> <option value="111" >Jersey</option> <option value="113" >Jordan</option> <option value="125" >Kazakhstan</option> <option value="115" >Kenya</option> <option value="118" >Kiribati</option> <option value="121" >Korea, Democratic People's Republic of</option> <option value="122" >Korea, Republic of</option> <option value="123" >Kuwait</option> <option value="116" >Kyrgyzstan</option> <option value="126" >Lao People's Democratic Republic</option> <option value="135" >Latvia</option> <option value="127" >Lebanon</option> <option value="132" >Lesotho</option> <option value="131" >Liberia</option> <option value="136" >Libyan Arab Jamahiriya</option> <option value="129" >Liechtenstein</option> <option value="133" >Lithuania</option> <option value="134" >Luxembourg</option> <option value="147" >Macao</option> <option value="143" >Macedonia</option> <option value="141" >Madagascar</option> <option value="155" >Malawi</option> <option value="157" >Malaysia</option> <option value="154" >Maldives</option> <option value="144" >Mali</option> <option value="152" >Malta</option> <option value="142" >Marshall Islands</option> <option value="149" >Martinique</option> <option value="150" >Mauritania</option> <option value="153" >Mauritius</option> <option value="243" >Mayotte</option> <option value="156" >Mexico</option> <option value="73" >Micronesia, Federated States of</option> <option value="139" >Moldova, Republic of</option> <option value="138" >Monaco</option> <option value="146" >Mongolia</option> <option value="140" >Montenegro</option> <option value="151" >Montserrat</option> <option value="137" >Morocco</option> <option value="158" >Mozambique</option> <option value="145" >Myanmar</option> <option value="159" >Namibia</option> <option value="168" >Nauru</option> <option value="167" >Nepal</option> <option value="165" >Netherlands</option> <option value="8" >Netherlands Antilles</option> <option value="160" >New Caledonia</option> <option value="170" >New Zealand</option> <option value="164" >Nicaragua</option> <option value="161" >Niger</option> <option value="163" >Nigeria</option> <option value="169" >Niue</option> <option value="162" >Norfolk Island</option> <option value="148" >Northern Mariana Islands</option> <option value="166" >Norway</option> <option value="0" >Not selected</option> <option value="171" >Oman</option> <option value="177" >Pakistan</option> <option value="184" >Palau</option> <option value="182" >Palestinian Territory</option> <option value="172" >Panama</option> <option value="175" >Papua New Guinea</option> <option value="185" >Paraguay</option> <option value="173" >Peru</option> <option value="176" >Philippines</option> <option value="180" >Pitcairn</option> <option value="178" >Poland</option> <option value="183" >Portugal</option> <option value="181" >Puerto Rico</option> <option value="186" >Qatar</option> <option value="187" >Reunion</option> <option value="188" >Romania</option> <option value="190" >Russian Federation</option> <option value="191" >Rwanda</option> <option value="198" >Saint Helena</option> <option value="120" >Saint Kitts and Nevis</option> <option value="128" >Saint Lucia</option> <option value="179" >Saint Pierre and Miquelon</option> <option value="234" >Saint Vincent and the Grenadines</option> <option value="241" >Samoa</option> <option value="203" >San Marino</option> <option value="207" >Sao Tome and Principe</option> <option value="192" >Saudi Arabia</option> <option value="204" >Senegal</option> <option value="189" >Serbia</option> <option value="194" >Seychelles</option> <option value="202" >Sierra Leone</option> <option value="197" >Singapore</option> <option value="201" >Slovakia</option> <option value="199" >Slovenia</option> <option value="193" >Solomon Islands</option> <option value="205" >Somalia</option> <option value="244" >South Africa</option> <option value="90" >South Georgia and the South Sandwich Islands</option> <option value="67" >Spain</option> <option value="130" >Sri Lanka</option> <option value="195" >Sudan</option> <option value="206" >Suriname</option> <option value="200" >Svalbard and Jan Mayen</option> <option value="210" >Swaziland</option> <option value="196" >Sweden</option> <option value="43" >Switzerland</option> <option value="209" >Syrian Arab Republic</option> <option value="225" >Taiwan</option> <option value="216" >Tajikistan</option> <option value="226" >Tanzania, United Republic of</option> <option value="215" >Thailand</option> <option value="218" >Timor-Leste</option> <option value="214" >Togo</option> <option value="217" >Tokelau</option> <option value="221" >Tonga</option> <option value="223" >Trinidad and Tobago</option> <option value="220" >Tunisia</option> <option value="222" >Turkey</option> <option value="219" >Turkmenistan</option> <option value="211" >Turks and Caicos Islands</option> <option value="224" >Tuvalu</option> <option value="228" >Uganda</option> <option value="227" >Ukraine</option> <option value="2" >United Arab Emirates</option> <option value="77" >United Kingdom</option> <option value="229" >United States Minor Outlying Islands</option> <option value="230" >United States of America</option> <option value="231" >Uruguay</option> <option value="232" >Uzbekistan</option> <option value="239" >Vanuatu</option> <option value="235" >Venezuela</option> <option value="238" >Vietnam</option> <option value="236" >Virgin Islands, British</option> <option value="237" >Virgin Islands, U.S.</option> <option value="240" >Wallis and Futuna</option> <option value="65" >Western Sahara</option> <option value="242" >Yemen</option> <option value="245" >Zambia</option> <option value="246" >Zimbabwe</option> </select> </validator></p> </fieldset> </template> <fieldset v-if="lead_data.has_sponsors"> <div v-show="!lead_data.auto_optin"> <div class="sponsorField"><div class="sponsorFieldLabel"><p>I would like to receive relevant information and insights from the sponsors of this issue, Aviva Systems, bit.bio, Merck, Ncardia, Thermo Fisher Scientific and Sartorius.<br /> <br /> </p> </div> <validator required :value="main_form.sponsor_opt_in[0]" ident="sponsor_1_opt_in" @validation-status="checkValidation"> <select name="sponsor_1_opt_in" class="form-dropdown" v-model="main_form.sponsor_opt_in[0]"> <option value="" >- select -</option> <option value="Yes" >Yes</option> <option value="No" >No</option> </select> </validator></div> </div> <template v-if="sponsorInfoRequired === 'required' || lead_data.auto_optin"> </template> </fieldset> <template v-if="!logged_in || lead_data.skip_registration"> <fieldset> <h3 class="fauxLabel">Email preferences</h3> <p>Please select which types of emails you would like to receive from Drug Target Review:</p> <ul class="checkboxes noBold"> <li><input type="checkbox" v-model="main_form.communications" value="news"><label>Newsletters and content updates</label></li> <li><input type="checkbox" v-model="main_form.communications" value="webinars"><label>Details of upcoming webinars</label></li> <li><input type="checkbox" v-model="main_form.communications" value="events"><label>Details of upcoming events</label></li> <li><input type="checkbox" v-model="main_form.communications" value="third_party"><label>Details of webinars, whitepapers, and new product developments from our trusted partners</label></li> </ul> </fieldset> </template> <ul class="checkboxes"> <li> <input type="checkbox" v-model="give_consent"> <label>I agree to Drug Target Review's <a href="https://www.drugtargetreview.com/terms-conditions" target="_blank">terms and conditions</a> and <a href="https://www.drugtargetreview.com/privacy-policy" target="_blank">privacy policy</a>. Your information will be processed in accordance with GDPR.</label> </li> </ul> <div class="hcaptcha"> <template> <vue-hcaptcha sitekey="b06c31fc-e90c-4c87-9a7c-cd4a82302865" @verify="hCaptchaVerify" :re-captcha-compat="false"></vue-hcaptcha> </template> </div> <button class="button" @click.prevent="changePage(prevPage)" v-if="showPrev">Previous</button> <button class="button brandColour" @click.prevent="finish" :disabled="!formComplete || busy.save">{{!formComplete ? 'Please complete all fields' : busy.save ? 'Saving...' : 'Submit'}}</button> </div> </step7-component> <terms-component inline-template v-show="current_page == 'terms'"> <div> <h4>Privacy policy / terms & conditions</h4> <p>Please review and accept Drug Target Review's privacy policy and terms & conditions</p> <ul class="checkboxes"> <li> <input type="checkbox" v-model="terms.accepted_terms"> <label>I confirm that by creating an account with Drug Target Review I accept the <a href="https://www.drugtargetreview.com/terms-conditions" target="_blank">terms and conditions</a> and <a href="https://www.drugtargetreview.com/privacy-policy" target="_blank">privacy policy</a></label> </li> </ul> <button class="button" @click.prevent="changePage('step4')">Previous</button> <button class="button brandColour" @click.prevent="advancePage" :disabled="!formComplete || busy.save">{{!formComplete ? 'Please accept the terms and conditions to proceed' : busy.save ? 'Saving...' : 'Next'}}</button> </div> </terms-component> <div id="the-content" v-show="current_page == 'completed'"> </div> </form> </div> </aside>  </div> <div id="wrapRight" class="wraps"> <div id="ad2"></div> <script type="text/javascript"> jQuery(document).ready(function() { var cur_width = jQuery(document).width(); console.log("Screen width: " + cur_width); if ( cur_width > 1597 ) { console.log("Showing show-if-gt in ad2 (167548)"); scrsize_load_url("ad2", 167548, 259436, 210, 900); } }); </script>  </div> </div> </div> </div> <div id="footerContainer"> <footer id="footer"> <div id="footerColumns"> <div class="column"> <h3>Content</h3> <ul> <li><a href="https://www.drugtargetreview.com/article">Articles</a></li> <li><a href="https://www.drugtargetreview.com/news">News</a></li> <li><a href="https://www.drugtargetreview.com/whitepaper">Whitepapers & App Notes</a></li> <li><a href="https://www.drugtargetreview.com/company_profile">Corporate Content</a></li> <li><a href="https://www.drugtargetreview.com/webinar">Webinars</a></li> <li><a href="https://www.drugtargetreview.com/news_type/blog">Blogs</a></li> <li><a href="https://www.drugtargetreview.com/events">Events</a></li> <li><a href="https://www.drugtargetreview.com/product">Products</a></li> <li><a href="https://www.drugtargetreview.com/journal">Issue Archive</a></li> </ul> </div> <div class="column"> <h3>Topics</h3> <ul> <li><a href="https://www.drugtargetreview.com/core_topic/targets">Targets</a></li> <li><a href="https://www.drugtargetreview.com/core_topic/screening">Screening</a></li> <li><a href="https://www.drugtargetreview.com/core_topic/stem-cells">Stem Cells</a></li> <li><a href="https://www.drugtargetreview.com/core_topic/hit-to-lead">Hit-to-lead</a></li> <li><a href="https://www.drugtargetreview.com/core_topic/omics">Omics</a></li> <li><a href="https://www.drugtargetreview.com/core_topic/imaging">Imaging</a></li> <li><a href="https://www.drugtargetreview.com/core_topic/informatics">Informatics</a></li> <li><a href="https://www.drugtargetreview.com/core_topic/regs-legs">Regs & Legs</a></li> </ul> </div> <div class="column"> <h3>Advertising & Editorial</h3> <ul> <li><a href="https://www.drugtargetreview.com/advertising-editorial/?target=media-planner">Media Planner</a></li> <li><a href="https://www.drugtargetreview.com/advertising-editorial/?target=publishing-schedule">Publishing Schedule</a></li> <li><a href="https://www.drugtargetreview.com/advertising-editorial/?target=advertising-opportunities">Advertising Opportunities</a></li> <li><a href="https://www.drugtargetreview.com/advertising-editorial/?target=advertising-tech-specs">Advertising Tech Specs</a></li> <li><a href="https://www.drugtargetreview.com/advertising-editorial/?target=author-information">Author Information</a></li> <li><a href="https://www.drugtargetreview.com/about-us/permission-to-reuse-our-content/">Permission to reuse our content</a></li> </ul> </div> <div class="column"> <p class="action"><a href="https://www.drugtargetreview.com/advertising-editorial/?target=author-information">Write for us</a> | <a href="https://www.drugtargetreview.com/advertising-editorial/?target=advertising-opportunities">Advertise with us</a></p> <a class="button contact" href="https://www.drugtargetreview.com/contact-us">Contact</a> <a class="button register" href="https://www.drugtargetreview.com/zmember/subscribers/register?lasturl=https://www.drugtargetreview.com/article/104912/drug-target-review-issue-3-2022/">Subscribe Today</a> <p><span>T:</span> +44 (0)1959 563311<br /> <span>F:</span> +44 (0)1959 563123</p> <div id="socialFooter"><p><a href="https://www.linkedin.com/company/drug-target-review" target="blank"><i class="fab fa-linkedin-in"></i></a> <a href="https://www.facebook.com/DrugTargetReview" target="blank"><i class="fab fa-facebook"></i></a> <a href="https://twitter.com/DrugTargetRev" target="blank"><i class="fab fa-twitter"></i></a>  <a href="http://feeds.feedburner.com/DrugTargetReview" target="blank"><i class="fas fa-rss"></i></a></p></div> </div> <div class="column"> <h3>Company Information</h3> <p><em>Drug Target Review</em> is published by: <br />Russell Publishing Ltd.<br />Court Lodge<br />Hogtrough Hill<br />Brasted, Kent, TN16 1NU<br />United Kingdom</p> <ul> <li><a href="https://www.drugtargetreview.com/about-us">About</a></li> <li><a href="https://www.russellpublishing.com/careers" target="_blank">Careers @ Russell Publishing</a></li> <li><a href="https://www.drugtargetreview.com/terms-conditions">Terms & Conditions</a></li> <li><a href="https://www.drugtargetreview.com/privacy-policy">Privacy Policy</a></li> <li><a href="https://www.drugtargetreview.com/cookie-policy">Cookie Policy</a></li> <li><a id="wt-cli-settings-btn" tabindex="0" role='button' style="display:inline-block; padding:8px 16px 8px; border-radius:4px; text-align:center; font-size:12px; border:solid 0px #fff; line-height:18px;" class="wt-cli-element large cli-plugin-button cli-plugin-main-button cli_settings_button" >Manage your cookies</a></li> </ul> </div> </div> </footer> </div> <div id="copyrightContainer"> <div id="copyright"><div id="footerLeft"><p>© <a href="http://www.russellpublishing.com" target="_blank">Russell Publishing Limited</a>, 2010-2024. All rights reserved. <span class="copyTerms"><a href="https://www.drugtargetreview.com/terms-conditions">Terms & Conditions</a> | <a href="https://www.drugtargetreview.com/privacy-policy">Privacy Policy</a> | <a href="https://www.drugtargetreview.com/cookie-policy">Cookie Policy</a></span></p></div> <div id="footerRight"><p><a href="http://www.e-motivemedia.com" target="blank">Website development by e-Motive Media Limited</a>.</p></div></div> </div> <script>(function(){var advanced_ads_ga_UID="UA-10556842-14",advanced_ads_ga_anonymIP=!!1;window.advanced_ads_check_adblocker=function(t){var n=[],e=null;function a(t){var n=window.requestAnimationFrame||window.mozRequestAnimationFrame||window.webkitRequestAnimationFrame||function(t){return setTimeout(t,16)};n.call(window,t)}return a((function(){var t=document.createElement("div");t.innerHTML=" ",t.setAttribute("class","ad_unit ad-unit text-ad text_ad pub_300x250"),t.setAttribute("style","width: 1px !important; height: 1px !important; position: absolute !important; left: 0px !important; top: 0px !important; overflow: hidden !important;"),document.body.appendChild(t),a((function(){var a,o,i=null===(a=(o=window).getComputedStyle)||void 0===a?void 0:a.call(o,t),d=null==i?void 0:i.getPropertyValue("-moz-binding");e=i&&"none"===i.getPropertyValue("display")||"string"==typeof d&&-1!==d.indexOf("about:");for(var c=0,r=n.length;c<r;c++)n[c](e);n=[]}))})),function(t){"undefined"==typeof advanced_ads_adblocker_test&&(e=!0),null!==e?t(e):n.push(t)}}(),(()=>{function t(t){this.UID=t,this.analyticsObject="function"==typeof gtag;var n=this;return this.count=function(){gtag("event","AdBlock",{event_category:"Advanced Ads",event_label:"Yes",non_interaction:!0,send_to:n.UID})},function(){if(!n.analyticsObject){var e=document.createElement("script");e.src="https://www.googletagmanager.com/gtag/js?id="+t,e.async=!0,document.body.appendChild(e),window.dataLayer=window.dataLayer||[],window.gtag=function(){dataLayer.push(arguments)},n.analyticsObject=!0,gtag("js",new Date)}var a={send_page_view:!1,transport_type:"beacon"};window.advanced_ads_ga_anonymIP&&(a.anonymize_ip=!0),gtag("config",t,a)}(),this}advanced_ads_check_adblocker((function(n){n&&new t(advanced_ads_ga_UID).count()}))})();})();</script>   <noscript><iframe data-lazyloaded="1" src="about:blank" data-src="https://www.googletagmanager.com/ns.html?id=GTM-KM6ZDN2" height="0" width="0"></iframe><noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-KM6ZDN2" height="0" width="0"></iframe></noscript></noscript>  <div class="wt-cli-cookie-bar-container" data-nosnippet="true"><div id="cookie-law-info-bar" role="dialog" aria-live="polite" aria-label="cookieconsent" aria-describedby="wt-cli-cookie-banner" data-cli-geo-loc="0" style="padding:10px; box-sizing:border-box; float:left; border:solid 0px #fff; font-size:14px;" class="wt-cli-cookie-bar"><div class="cli-wrapper"><span id="wt-cli-cookie-banner"><div class="cli-bar-container cli-style-v2"><div class="cli-bar-message">This website uses cookies to enable, optimise and analyse site operations, as well as to provide personalised content and allow you to connect to social media. By clicking "I agree" you consent to the use of cookies for non-essential functions and the related processing of personal data. You can adjust your cookie and associated data processing preferences at any time via our "Cookie Settings". Please view our <a href="/cookie-policy/">Cookie Policy</a> to learn more about the use of cookies on our website.</div><div class="cli-bar-btn_container"><a id="wt-cli-settings-btn" tabindex="0" role='button' style="display:inline-block; padding:8px 16px 8px; border-radius:4px; text-align:center; font-size:12px; border:solid 0px #fff; line-height:18px;" class="wt-cli-element large cli-plugin-button cli-plugin-main-button cli_settings_button" >Manage your cookies</a> <a id="wt-cli-accept-btn" tabindex="0" role='button' style="display:inline-block; padding:8px 16px 8px; border-radius:4px; text-align:center; font-size:12px; border:solid 0px #fff; line-height:18px;" data-cli_action="accept" class="wt-cli-element large cli-plugin-button cli-plugin-main-button cookie_action_close_header cli_action_button" >I agree</a></div></div></span></div></div><div tabindex="0" id="cookie-law-info-again" style="display:none;"><span id="cookie_hdr_showagain">Cookie Settings</span></div><div class="cli-modal" id="cliSettingsPopup" role="dialog" aria-labelledby="wt-cli-privacy-title" tabindex="-1" aria-hidden="true"> <div class="cli-modal-dialog" role="document"> <div class="cli-modal-content cli-bar-popup"> <button aria-label="Close" type="button" class="cli-modal-close" id="cliModalClose"> <svg class="" viewBox="0 0 24 24"><path d="M19 6.41l-1.41-1.41-5.59 5.59-5.59-5.59-1.41 1.41 5.59 5.59-5.59 5.59 1.41 1.41 5.59-5.59 5.59 5.59 1.41-1.41-5.59-5.59z"></path><path d="M0 0h24v24h-24z" fill="none"></path></svg> <span class="wt-cli-sr-only">Close</span> </button> <div class="cli-modal-body"> <div class="wt-cli-element cli-container-fluid cli-tab-container"> <div class="cli-row"> <div class="cli-col-12 cli-align-items-stretch cli-px-0"> <div class="cli-privacy-overview"> <h4 id='wt-cli-privacy-title'>Cookie Settings</h4> <div class="cli-privacy-content"> <div class="cli-privacy-content-text"><p>This website uses cookies to improve your experience while you navigate through the website. Out of these cookies, the cookies that are categorised as "Necessary" are stored on your browser as they are as essential for the working of basic functionalities of the website. For our other types of cookies "Advertising & Targeting", "Analytics" and "Performance", these help us analyse and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these different types of cookies. But opting out of some of these cookies may have an effect on your browsing experience. You can adjust the available sliders to 'Enabled' or 'Disabled', then click 'Save and Accept'. View our <a href="/cookie-policy/">Cookie Policy</a> page.</p></div> </div> <a id="wt-cli-privacy-readmore" tabindex="0" role="button" class="cli-privacy-readmore" data-readmore-text="Show more" data-readless-text="Show less"></a> </div> </div> <div class="cli-col-12 cli-align-items-stretch cli-px-0 cli-tab-section-container" role="tablist"> <div class="cli-tab-section"> <div class="cli-tab-header"> <a id="wt-cli-tab-link-necessary" tabindex="0" role="tab" aria-expanded="false" aria-describedby="wt-cli-tab-necessary" aria-controls="wt-cli-tab-necessary" class="cli-nav-link cli-settings-mobile" data-target="necessary" data-toggle="cli-toggle-tab"> Necessary </a> <div class="wt-cli-necessary-checkbox"> <input type="checkbox" class="cli-user-preference-checkbox" id="wt-cli-checkbox-necessary" aria-label="Necessary" data-id="checkbox-necessary" checked="checked" /> <label class="form-check-label" for="wt-cli-checkbox-necessary"> Necessary </label> </div> <span class="cli-necessary-caption"> Always Enabled </span> </div> <div class="cli-tab-content"> <div id="wt-cli-tab-necessary" tabindex="0" role="tabpanel" aria-labelledby="wt-cli-tab-link-necessary" class="cli-tab-pane cli-fade" data-id="necessary"> <div class="wt-cli-cookie-description"><p>Necessary cookies enable the core functionality of the website, including security, network management and accessibility. These cookies do not store any personal information. You may disable these by changing your browser settings, but this may affect how the website functions.</p> <p><table class="wt-cli-element cookielawinfo-row-cat-table cookielawinfo-winter"><thead><tr><th scope="col" class="cookielawinfo-column-1">Cookie</th><th scope="col" class="cookielawinfo-column-2">Type</th><th scope="col" class="cookielawinfo-column-3">Duration</th><th scope="col" class="cookielawinfo-column-4">Description</th></tr></thead><tbody><tr class="cookielawinfo-row"><td class="cookielawinfo-column-1">cookielawinfo-checkbox-advertising-targeting</td><td class="cookielawinfo-column-2">persistent</td><td class="cookielawinfo-column-3">1 year</td><td class="cookielawinfo-column-4">The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Advertising & Targeting".</td></tr><tr class="cookielawinfo-row"><td class="cookielawinfo-column-1">cookielawinfo-checkbox-analytics</td><td class="cookielawinfo-column-2">persistent</td><td class="cookielawinfo-column-3">1 year</td><td class="cookielawinfo-column-4">This cookie is set by GDPR Cookie Consent WordPress Plugin. The cookie is used to remember the user consent for the cookies under the category "Analytics".</td></tr><tr class="cookielawinfo-row"><td class="cookielawinfo-column-1">cookielawinfo-checkbox-necessary</td><td class="cookielawinfo-column-2">persistent</td><td class="cookielawinfo-column-3">1 year</td><td class="cookielawinfo-column-4">This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Necessary".</td></tr><tr class="cookielawinfo-row"><td class="cookielawinfo-column-1">cookielawinfo-checkbox-performance</td><td class="cookielawinfo-column-2">persistent</td><td class="cookielawinfo-column-3">1 year</td><td class="cookielawinfo-column-4">This cookie is set by GDPR Cookie Consent WordPress Plugin. The cookie is used to remember the user consent for the cookies under the category "Performance".</td></tr><tr class="cookielawinfo-row"><td class="cookielawinfo-column-1">PHPSESSID</td><td class="cookielawinfo-column-2">session</td><td class="cookielawinfo-column-3">1 year</td><td class="cookielawinfo-column-4">This cookie is native to PHP applications. The cookie is used to store and identify a users' unique session ID for the purpose of managing user session on the website. The cookie is a session cookies and is deleted when all the browser windows are closed.</td></tr><tr class="cookielawinfo-row"><td class="cookielawinfo-column-1">viewed_cookie_policy</td><td class="cookielawinfo-column-2">persistent</td><td class="cookielawinfo-column-3">1 year</td><td class="cookielawinfo-column-4">The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. It does not store any personal data.</td></tr><tr class="cookielawinfo-row"><td class="cookielawinfo-column-1">zmember_logged</td><td class="cookielawinfo-column-2">session</td><td class="cookielawinfo-column-3">1 year</td><td class="cookielawinfo-column-4">This session cookie is served by our membership/subscription system and controls whether you are able to see content which is only available to logged in users.</td></tr></tbody></table></p></div> </div> </div> </div> <div class="cli-tab-section"> <div class="cli-tab-header"> <a id="wt-cli-tab-link-advertising-targeting" tabindex="0" role="tab" aria-expanded="false" aria-describedby="wt-cli-tab-advertising-targeting" aria-controls="wt-cli-tab-advertising-targeting" class="cli-nav-link cli-settings-mobile" data-target="advertising-targeting" data-toggle="cli-toggle-tab"> Advertising & Targeting </a> <div class="cli-switch"> <input type="checkbox" class="cli-user-preference-checkbox" id="wt-cli-checkbox-advertising-targeting" aria-label="advertising-targeting" data-id="checkbox-advertising-targeting" role="switch" aria-controls="wt-cli-tab-link-advertising-targeting" aria-labelledby="wt-cli-tab-link-advertising-targeting" checked='checked' /> <label for="wt-cli-checkbox-advertising-targeting" class="cli-slider" data-cli-enable="Enabled" data-cli-disable="Disabled"><span class="wt-cli-sr-only">advertising-targeting</span></label> </div> </div> <div class="cli-tab-content"> <div id="wt-cli-tab-advertising-targeting" tabindex="0" role="tabpanel" aria-labelledby="wt-cli-tab-link-advertising-targeting" class="cli-tab-pane cli-fade" data-id="advertising-targeting"> <div class="wt-cli-cookie-description"><p>Advertising and targeting cookies help us provide our visitors with relevant ads and marketing campaigns.</p> <p><table class="wt-cli-element cookielawinfo-row-cat-table cookielawinfo-winter"><thead><tr><th scope="col" class="cookielawinfo-column-1">Cookie</th><th scope="col" class="cookielawinfo-column-2">Type</th><th scope="col" class="cookielawinfo-column-3">Duration</th><th scope="col" class="cookielawinfo-column-4">Description</th></tr></thead><tbody><tr class="cookielawinfo-row"><td class="cookielawinfo-column-1">advanced_ads_browser_width</td><td class="cookielawinfo-column-2">persistent</td><td class="cookielawinfo-column-3">1 month</td><td class="cookielawinfo-column-4">This cookie is set by Advanced Ads and measures the browser width.</td></tr><tr class="cookielawinfo-row"><td class="cookielawinfo-column-1">advanced_ads_page_impressions</td><td class="cookielawinfo-column-2">persistent</td><td class="cookielawinfo-column-3">2 years</td><td class="cookielawinfo-column-4">This cookie is set by Advanced Ads and measures the number of previous page impressions.</td></tr><tr class="cookielawinfo-row"><td class="cookielawinfo-column-1">advanced_ads_pro_server_info</td><td class="cookielawinfo-column-2">persistent</td><td class="cookielawinfo-column-3">1 month</td><td class="cookielawinfo-column-4">This cookie is set by Advanced Ads and sets geo-location, user role and user capabilities. It is used by cache busting in Advanced Ads Pro when the appropriate visitor conditions are used.</td></tr><tr class="cookielawinfo-row"><td class="cookielawinfo-column-1">advanced_ads_pro_visitor_referrer</td><td class="cookielawinfo-column-2">persistent</td><td class="cookielawinfo-column-3">1 year</td><td class="cookielawinfo-column-4">This cookie is set by Advanced Ads and sets the referrer URL.</td></tr><tr class="cookielawinfo-row"><td class="cookielawinfo-column-1">bscookie</td><td class="cookielawinfo-column-2">persistent</td><td class="cookielawinfo-column-3">2 years</td><td class="cookielawinfo-column-4">This cookie is a browser ID cookie set by LinkedIn share Buttons and ad tags.</td></tr><tr class="cookielawinfo-row"><td class="cookielawinfo-column-1">IDE</td><td class="cookielawinfo-column-2">persistent</td><td class="cookielawinfo-column-3">2 years</td><td class="cookielawinfo-column-4">This cookie is set by Google DoubleClick and stores information about how the user uses the website and any other advertisement before visiting the website. This is used to present users with ads that are relevant to them according to the user profile.</td></tr><tr class="cookielawinfo-row"><td class="cookielawinfo-column-1">li_sugr</td><td class="cookielawinfo-column-2">persistent</td><td class="cookielawinfo-column-3">3 months</td><td class="cookielawinfo-column-4">This cookie is set by LinkedIn and is used for tracking.</td></tr><tr class="cookielawinfo-row"><td class="cookielawinfo-column-1">UserMatchHistory</td><td class="cookielawinfo-column-2">persistent</td><td class="cookielawinfo-column-3">1 month</td><td class="cookielawinfo-column-4">This cookie is set by Linkedin and is used to track visitors on multiple websites, in order to present relevant advertisement based on the visitor's preferences.</td></tr><tr class="cookielawinfo-row"><td class="cookielawinfo-column-1">VISITOR_INFO1_LIVE</td><td class="cookielawinfo-column-2">persistent</td><td class="cookielawinfo-column-3">5 months</td><td class="cookielawinfo-column-4">This cookie is set by YouTube. Used to track the information of the embedded YouTube videos on a website.</td></tr></tbody></table></p></div> </div> </div> </div> <div class="cli-tab-section"> <div class="cli-tab-header"> <a id="wt-cli-tab-link-analytics" tabindex="0" role="tab" aria-expanded="false" aria-describedby="wt-cli-tab-analytics" aria-controls="wt-cli-tab-analytics" class="cli-nav-link cli-settings-mobile" data-target="analytics" data-toggle="cli-toggle-tab"> Analytics </a> <div class="cli-switch"> <input type="checkbox" class="cli-user-preference-checkbox" id="wt-cli-checkbox-analytics" aria-label="analytics" data-id="checkbox-analytics" role="switch" aria-controls="wt-cli-tab-link-analytics" aria-labelledby="wt-cli-tab-link-analytics" checked='checked' /> <label for="wt-cli-checkbox-analytics" class="cli-slider" data-cli-enable="Enabled" data-cli-disable="Disabled"><span class="wt-cli-sr-only">analytics</span></label> </div> </div> <div class="cli-tab-content"> <div id="wt-cli-tab-analytics" tabindex="0" role="tabpanel" aria-labelledby="wt-cli-tab-link-analytics" class="cli-tab-pane cli-fade" data-id="analytics"> <div class="wt-cli-cookie-description"><p>Analytics cookies collect information about your use of the content, and in combination with previously collected information, are used to measure, understand, and report on your usage of this website.</p> <p><table class="wt-cli-element cookielawinfo-row-cat-table cookielawinfo-winter"><thead><tr><th scope="col" class="cookielawinfo-column-1">Cookie</th><th scope="col" class="cookielawinfo-column-2">Type</th><th scope="col" class="cookielawinfo-column-3">Duration</th><th scope="col" class="cookielawinfo-column-4">Description</th></tr></thead><tbody><tr class="cookielawinfo-row"><td class="cookielawinfo-column-1">bcookie</td><td class="cookielawinfo-column-2">persistent</td><td class="cookielawinfo-column-3">2 years</td><td class="cookielawinfo-column-4">This cookie is set by LinkedIn. The purpose of the cookie is to enable LinkedIn functionalities on the page.</td></tr><tr class="cookielawinfo-row"><td class="cookielawinfo-column-1">GPS</td><td class="cookielawinfo-column-2">persistent</td><td class="cookielawinfo-column-3">30 minutes</td><td class="cookielawinfo-column-4">This cookie is set by YouTube and registers a unique ID for tracking users based on their geographical location</td></tr><tr class="cookielawinfo-row"><td class="cookielawinfo-column-1">lang</td><td class="cookielawinfo-column-2">session</td><td class="cookielawinfo-column-3">1 year</td><td class="cookielawinfo-column-4">This cookie is set by LinkedIn and is used to store the language preferences of a user to serve up content in that stored language the next time user visit the website.</td></tr><tr class="cookielawinfo-row"><td class="cookielawinfo-column-1">lidc</td><td class="cookielawinfo-column-2">persistent</td><td class="cookielawinfo-column-3">1 day</td><td class="cookielawinfo-column-4">This cookie is set by LinkedIn and used for routing.</td></tr><tr class="cookielawinfo-row"><td class="cookielawinfo-column-1">lissc</td><td class="cookielawinfo-column-2">persistent</td><td class="cookielawinfo-column-3">11 months</td><td class="cookielawinfo-column-4">This cookie is set by LinkedIn share Buttons and ad tags.</td></tr><tr class="cookielawinfo-row"><td class="cookielawinfo-column-1">vuid</td><td class="cookielawinfo-column-2">persistent</td><td class="cookielawinfo-column-3">2 years</td><td class="cookielawinfo-column-4">We embed videos from our official Vimeo channel. When you press play, Vimeo will drop third party cookies to enable the video to play and to see how long a viewer has watched the video. This cookie does not track individuals.</td></tr><tr class="cookielawinfo-row"><td class="cookielawinfo-column-1">wow.anonymousId</td><td class="cookielawinfo-column-2">persistent</td><td class="cookielawinfo-column-3">2 years</td><td class="cookielawinfo-column-4">This cookie is set by Spotler and tracks an anonymous visitor ID.</td></tr><tr class="cookielawinfo-row"><td class="cookielawinfo-column-1">wow.schedule</td><td class="cookielawinfo-column-2">persistent</td><td class="cookielawinfo-column-3">20 minutes</td><td class="cookielawinfo-column-4">This cookie is set by Spotler and enables it to track the Load Balance Session Queue.</td></tr><tr class="cookielawinfo-row"><td class="cookielawinfo-column-1">wow.session</td><td class="cookielawinfo-column-2">persistent</td><td class="cookielawinfo-column-3">20 minutes</td><td class="cookielawinfo-column-4">This cookie is set by Spotler to track the Internet Information Services (IIS) session state.</td></tr><tr class="cookielawinfo-row"><td class="cookielawinfo-column-1">wow.utmvalues</td><td class="cookielawinfo-column-2">persistent</td><td class="cookielawinfo-column-3">20 minutes</td><td class="cookielawinfo-column-4">This cookie is set by Spotler and stores the UTM values for the session. UTM values are specific text strings that are appended to URLs that allow Communigator to track the URLs and the UTM values when they get clicked on.</td></tr><tr class="cookielawinfo-row"><td class="cookielawinfo-column-1">_ga</td><td class="cookielawinfo-column-2">persistent</td><td class="cookielawinfo-column-3">2 years</td><td class="cookielawinfo-column-4">This cookie is set by Google Analytics and is used to calculate visitor, session, campaign data and keep track of site usage for the site's analytics report. It stores information anonymously and assign a randomly generated number to identify unique visitors.</td></tr><tr class="cookielawinfo-row"><td class="cookielawinfo-column-1">_gat</td><td class="cookielawinfo-column-2">persistent</td><td class="cookielawinfo-column-3">1 minute</td><td class="cookielawinfo-column-4">This cookies is set by Google Universal Analytics to throttle the request rate to limit the collection of data on high traffic sites.</td></tr><tr class="cookielawinfo-row"><td class="cookielawinfo-column-1">_gid</td><td class="cookielawinfo-column-2">persistent</td><td class="cookielawinfo-column-3">1 day</td><td class="cookielawinfo-column-4">This cookie is set by Google Analytics and is used to store information of how visitors use a website and helps in creating an analytics report of how the website is doing. The data collected including the number visitors, the source where they have come from, and the pages visited in an anonymous form.</td></tr></tbody></table></p></div> </div> </div> </div> <div class="cli-tab-section"> <div class="cli-tab-header"> <a id="wt-cli-tab-link-performance" tabindex="0" role="tab" aria-expanded="false" aria-describedby="wt-cli-tab-performance" aria-controls="wt-cli-tab-performance" class="cli-nav-link cli-settings-mobile" data-target="performance" data-toggle="cli-toggle-tab"> Performance </a> <div class="cli-switch"> <input type="checkbox" class="cli-user-preference-checkbox" id="wt-cli-checkbox-performance" aria-label="performance" data-id="checkbox-performance" role="switch" aria-controls="wt-cli-tab-link-performance" aria-labelledby="wt-cli-tab-link-performance" checked='checked' /> <label for="wt-cli-checkbox-performance" class="cli-slider" data-cli-enable="Enabled" data-cli-disable="Disabled"><span class="wt-cli-sr-only">performance</span></label> </div> </div> <div class="cli-tab-content"> <div id="wt-cli-tab-performance" tabindex="0" role="tabpanel" aria-labelledby="wt-cli-tab-link-performance" class="cli-tab-pane cli-fade" data-id="performance"> <div class="wt-cli-cookie-description"><p>Performance cookies include cookies that deliver enhanced functionalities of the website, such as caching. These cookies do not store any personal information.</p> <p><table class="wt-cli-element cookielawinfo-row-cat-table cookielawinfo-winter"><thead><tr><th scope="col" class="cookielawinfo-column-1">Cookie</th><th scope="col" class="cookielawinfo-column-2">Type</th><th scope="col" class="cookielawinfo-column-3">Duration</th><th scope="col" class="cookielawinfo-column-4">Description</th></tr></thead><tbody><tr class="cookielawinfo-row"><td class="cookielawinfo-column-1">cf_ob_info</td><td class="cookielawinfo-column-2">persistent</td><td class="cookielawinfo-column-3">1 minute</td><td class="cookielawinfo-column-4">This cookie is set by Cloudflare content delivery network and, in conjunction with the cookie 'cf_use_ob', is used to determine whether it should continue serving “Always Online” until the cookie expires.</td></tr><tr class="cookielawinfo-row"><td class="cookielawinfo-column-1">cf_use_ob</td><td class="cookielawinfo-column-2">persistent</td><td class="cookielawinfo-column-3">1 minute</td><td class="cookielawinfo-column-4">This cookie is set by Cloudflare content delivery network and is used to determine whether it should continue serving “Always Online” until the cookie expires.</td></tr><tr class="cookielawinfo-row"><td class="cookielawinfo-column-1">free_subscription_only</td><td class="cookielawinfo-column-2">session</td><td class="cookielawinfo-column-3">1 year</td><td class="cookielawinfo-column-4">This session cookie is served by our membership/subscription system and controls which types of content you are able to access.</td></tr><tr class="cookielawinfo-row"><td class="cookielawinfo-column-1">ls_smartpush</td><td class="cookielawinfo-column-2">persistent</td><td class="cookielawinfo-column-3">1 month</td><td class="cookielawinfo-column-4">This cookie is set by Litespeed Server and allows the server to store settings to help improve performance of the site.</td></tr><tr class="cookielawinfo-row"><td class="cookielawinfo-column-1">one_signal_sdk_db</td><td class="cookielawinfo-column-2">persistent</td><td class="cookielawinfo-column-3">Until cleared</td><td class="cookielawinfo-column-4">This cookie is set by OneSignal push notifications and is used for storing user preferences in connection with their notification permission status.</td></tr><tr class="cookielawinfo-row"><td class="cookielawinfo-column-1">YSC</td><td class="cookielawinfo-column-2">session</td><td class="cookielawinfo-column-3">1 year</td><td class="cookielawinfo-column-4">This cookie is set by Youtube and is used to track the views of embedded videos.</td></tr></tbody></table></p></div> </div> </div> </div> </div> </div> </div> </div> <div class="cli-modal-footer"> <div class="wt-cli-element cli-container-fluid cli-tab-container"> <div class="cli-row"> <div class="cli-col-12 cli-align-items-stretch cli-px-0"> <div class="cli-tab-footer wt-cli-privacy-overview-actions"> <a id="wt-cli-privacy-save-btn" role="button" tabindex="0" data-cli-action="accept" class="wt-cli-privacy-btn cli_setting_save_button wt-cli-privacy-accept-btn cli-btn">Save & Accept</a> </div> </div> </div> </div> </div> </div> </div> </div> <div class="cli-modal-backdrop cli-fade cli-settings-overlay"></div> <div class="cli-modal-backdrop cli-fade cli-popupbar-overlay"></div> </div> <script type="text/javascript"> /* <![CDATA[ */ cli_cookiebar_settings='{"animate_speed_hide":"500","animate_speed_show":"500","background":"rgb(255, 255, 255)","border":"#3c3c3b","border_on":false,"button_1_button_colour":"rgb(135, 31, 128)","button_1_button_hover":"rgb(135, 31, 128)","button_1_link_colour":"#fff","button_1_as_button":true,"button_1_new_win":false,"button_2_button_colour":"rgb(51, 51, 51)","button_2_button_hover":"rgb(51, 51, 51)","button_2_link_colour":"#871f80","button_2_as_button":false,"button_2_hidebar":false,"button_2_nofollow":true,"button_3_button_colour":"rgb(0, 0, 0)","button_3_button_hover":"rgb(0, 0, 0)","button_3_link_colour":"#fff","button_3_as_button":true,"button_3_new_win":false,"button_4_button_colour":"#871f80","button_4_button_hover":"#6c1966","button_4_link_colour":"#ffffff","button_4_as_button":true,"button_7_button_colour":"#61a229","button_7_button_hover":"#4e8221","button_7_link_colour":"#fff","button_7_as_button":true,"button_7_new_win":false,"font_family":"inherit","header_fix":false,"notify_animate_hide":true,"notify_animate_show":true,"notify_div_id":"#cookie-law-info-bar","notify_position_horizontal":"right","notify_position_vertical":"bottom","scroll_close":false,"scroll_close_reload":false,"accept_close_reload":false,"reject_close_reload":false,"showagain_tab":true,"showagain_background":"#fff","showagain_border":"#000","showagain_div_id":"#cookie-law-info-again","showagain_x_position":"0px","text":"#3c3c3b","show_once_yn":false,"show_once":"10000","logging_on":false,"as_popup":false,"popup_overlay":true,"bar_heading_text":"","cookie_bar_as":"banner","cookie_setting_popup":true,"accept_all":true,"js_script_blocker":false,"popup_showagain_position":"bottom-right","widget_position":"left","button_1_style":[["display","inline-block"],["padding","8px 16px 8px"],["border-radius","4px"],["text-align","center"],["font-size","12px"],["border","solid 0px #fff"],["line-height","18px"]],"button_2_style":[["display","inline-block"],["text-align","center"],["font-size","14px"],["padding","8px 16px 8px"],["border","solid 0px #fff"],["line-height","18px"]],"button_3_style":[["display","inline-block"],["padding","8px 16px 8px"],["border-radius","4px"],["text-align","center"],["font-size","12px"],["border","solid 0px #fff"],["line-height","18px"]],"button_4_style":[["display","inline-block"],["padding","8px 16px 8px"],["border-radius","4px"],["text-align","center"],["font-size","12px"],["border","solid 0px #fff"],["line-height","18px"]],"button_5_style":[["display","inline-block"],["background","none"],["border-radius","20px"],["border","solid 1px #000"],["color","#000"],["text-align","center"],["font-size","12px"],["width","22px"],["height","22px"],["line-height","22px"],["margin-right","-15px"],["margin-top","-15px"],["float","right"],["cursor","pointer"],[""],["background-color","rgba(0, 0, 0, 0)"]],"button_7_style":[["margin","5px 5px 5px 30px"],["border-radius","0"],["padding","8px 25px 8px 25px"]],"accept_close_page_navigation":false}'; /* ]]> */ </script> <link rel='stylesheet' id='cookie-law-info-table-css' href='https://www.drugtargetreview.com/wp-content/plugins/webtoffee-gdpr-cookie-consent/public/css/cookie-law-info-table.css?ver=2.4.0' type='text/css' media='all' /> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-content/plugins/contact-form-7-redirection-pro/assets/js/wpcf7-redirect-frontend-script.js" id="wpcf7-redirect-script-js"></script> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-includes/js/dist/hooks.min.js?ver=2810c76e705dd1a53b18" id="wp-hooks-js"></script> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-includes/js/dist/i18n.min.js?ver=5e580eb46a90c2b997e6" id="wp-i18n-js"></script> <script type="text/javascript" id="wp-i18n-js-after"> /* <![CDATA[ */ wp.i18n.setLocaleData( { 'text direction\u0004ltr': [ 'ltr' ] } ); wp.i18n.setLocaleData( { 'text direction\u0004ltr': [ 'ltr' ] } ); /* ]]> */ </script> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-content/plugins/contact-form-7/includes/swv/js/index.js?ver=5.9.8" id="swv-js"></script> <script type="text/javascript" id="contact-form-7-js-extra"> /* <![CDATA[ */ var wpcf7 = {"api":{"root":"https:\/\/www.drugtargetreview.com\/wp-json\/","namespace":"contact-form-7\/v1"},"cached":"1"}; /* ]]> */ </script> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-content/plugins/contact-form-7/includes/js/index.js?ver=5.9.8" id="contact-form-7-js"></script> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-content/plugins/ditty-news-ticker/legacy/inc/static/js/swiped-events.min.js?ver=1.1.4" id="swiped-events-js"></script> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-includes/js/imagesloaded.min.js?ver=5.0.0" id="imagesloaded-js"></script> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-includes/js/jquery/ui/effect.min.js?ver=1.13.3" id="jquery-effects-core-js"></script> <script type="text/javascript" id="ditty-news-ticker-js-extra"> /* <![CDATA[ */ var mtphr_dnt_vars = {"is_rtl":""}; /* ]]> */ </script> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-content/plugins/ditty-news-ticker/legacy/inc/static/js/ditty-news-ticker.js?ver=3.1.48" id="ditty-news-ticker-js"></script> <script type="text/javascript" id="advanced-ads-pro/cache_busting-js-extra"> /* <![CDATA[ */ var advanced_ads_pro_ajax_object = {"ajax_url":"https:\/\/www.drugtargetreview.com\/wp-admin\/admin-ajax.php","lazy_load_module_enabled":"","lazy_load":{"default_offset":0,"offsets":[]},"moveintohidden":"","wp_timezone_offset":"0","the_id":"104912","is_singular":"1"}; var advanced_ads_responsive = {"reload_on_resize":"1"}; /* ]]> */ </script> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-content/uploads/289/985/assets/js/221.js?ver=2.27.0" id="advanced-ads-pro/cache_busting-js"></script> <script type="text/javascript" id="advanced-ads-layer-footer-js-js-extra"> /* <![CDATA[ */ var advanced_ads_layer_settings = {"layer_class":"drugt-layer","placements":["before-you-go"]}; /* ]]> */ </script> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-content/uploads/289/667/public/assets/js/898.js?ver=1.7.8" id="advanced-ads-layer-footer-js-js"></script> <script type="text/javascript" id="advanced-ads-sticky-footer-js-js-extra"> /* <![CDATA[ */ var advanced_ads_sticky_settings = {"check_position_fixed":"","sticky_class":"drugt-sticky","placements":["fixed-footer","fixed-footer-fallback-1","fixed-footer-super-leaderboard"]}; /* ]]> */ </script> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-content/uploads/289/986/public/assets/js/300.js?ver=1.8.5" id="advanced-ads-sticky-footer-js-js"></script> <script type="text/javascript" id="tptn_tracker-js-extra"> /* <![CDATA[ */ var ajax_tptn_tracker = {"ajax_url":"https:\/\/www.drugtargetreview.com\/wp-admin\/admin-ajax.php","top_ten_id":"104912","top_ten_blog_id":"1","activate_counter":"11","top_ten_debug":"0","tptn_rnd":"1328823447"}; /* ]]> */ </script> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-content/plugins/top-10/includes/js/top-10-tracker.min.js?ver=4.0.1" id="tptn_tracker-js"></script> <script type="text/javascript" id="advanced-ads-pro/front-js-extra"> /* <![CDATA[ */ var advanced_ads_cookies = {"cookie_path":"\/","cookie_domain":""}; var advadsCfpInfo = {"cfpExpHours":"3","cfpClickLimit":"3","cfpBan":"7","cfpPath":"","cfpDomain":"www.drugtargetreview.com"}; /* ]]> */ </script> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-content/uploads/289/985/assets/js/962.js?ver=2.27.0" id="advanced-ads-pro/front-js"></script> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-content/plugins/page-links-to/dist/new-tab.js?ver=3.3.7" id="page-links-to-js"></script> <script type="text/javascript" src="https://js.stripe.com/v3/" id="zform-stripe-js"></script> <script type="text/javascript" src="https://cdn.jsdelivr.net/npm/jquery-validation@1.19.3/dist/jquery.validate.min.js" id="zform-jquery-validate-js"></script> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-content/plugins/zform/js/z_lead_form/chunk-vendors.js?r=1618756343" id="zform-vuejs-js"></script> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-content/plugins/zform/js/z_lead_form/app.js?r=1339528182" id="zform-app-js"></script> <script type="text/javascript" id="advadsTrackingScript-js-extra"> /* <![CDATA[ */ var advadsTracking = {"impressionActionName":"aatrack-records","clickActionName":"aatrack-click","targetClass":"drugt-target","blogId":"1","frontendPrefix":"drugt-"}; /* ]]> */ </script> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-content/uploads/289/999/public/assets/js/420/839.js?ver=2.8.1" id="advadsTrackingScript-js"></script> <script type="text/javascript" id="advadsTrackingGAFront-js-extra"> /* <![CDATA[ */ var advadsTrackingGAEvents = {"impression":"advanced_ads_impression","click":"advanced_ads_click"}; /* ]]> */ </script> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-content/uploads/289/999/public/assets/js/420/42.js?ver=2.8.1" id="advadsTrackingGAFront-js"></script> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-content/uploads/289/999/public/assets/js/420/588.js?ver=2.8.1" id="advadsTrackingDelayed-js"></script> <script type="text/javascript" id="wpcf7cf-scripts-js-extra"> /* <![CDATA[ */ var wpcf7cf_global_settings = {"ajaxurl":"https:\/\/www.drugtargetreview.com\/wp-admin\/admin-ajax.php"}; /* ]]> */ </script> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-content/plugins/cf7-conditional-fields/js/scripts.js?ver=2.5" id="wpcf7cf-scripts-js"></script> <script type="text/javascript" id="ubermenu-js-extra"> /* <![CDATA[ */ var ubermenu_data = {"remove_conflicts":"on","reposition_on_load":"off","intent_delay":"300","intent_interval":"100","intent_threshold":"7","scrollto_offset":"50","scrollto_duration":"1000","responsive_breakpoint":"1180","accessible":"on","mobile_menu_collapse_on_navigate":"on","retractor_display_strategy":"responsive","touch_off_close":"on","submenu_indicator_close_mobile":"on","collapse_after_scroll":"on","v":"3.8.1","configurations":["main"],"ajax_url":"https:\/\/www.drugtargetreview.com\/wp-admin\/admin-ajax.php","plugin_url":"https:\/\/www.drugtargetreview.com\/wp-content\/plugins\/ubermenu\/","disable_mobile":"off","prefix_boost":"","use_core_svgs":"off","aria_role_navigation":"off","aria_nav_label":"off","aria_expanded":"off","aria_hidden":"off","aria_controls":"","aria_responsive_toggle":"off","icon_tag":"i","esc_close_mobile":"on","keyboard_submenu_trigger":"enter","theme_locations":{"primary_nav":"Primary Navigation","secondary_nav":"Secondary Navigation"}}; /* ]]> */ </script> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-content/plugins/ubermenu/assets/js/ubermenu.min.js?ver=3.8.1" id="ubermenu-js"></script> <script type="text/javascript" id="wpa.longdesc-js-extra"> /* <![CDATA[ */ var wpald = {"url":"https:\/\/www.drugtargetreview.com\/wp-json\/wp\/v2\/media","type":"jquery","text":"<span class=\"dashicons dashicons-media-text\" aria-hidden=\"true\"><\/span><span class=\"screen-reader\">Long Description<\/span>"}; /* ]]> */ </script> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-content/plugins/wp-accessibility/js/longdesc.min.js?ver=1.7.6" id="wpa.longdesc-js"></script> <script type="text/javascript" id="wp-accessibility-js-extra"> /* <![CDATA[ */ var wpa = {"skiplinks":{"enabled":false,"output":""},"target":"","tabindex":"1","underline":{"enabled":false,"target":"a"},"dir":"ltr","lang":"en-GB","titles":"1","labels":"1","wpalabels":{"s":"Search","author":"Name","email":"Email","url":"Website","comment":"Comment"},"current":"","errors":"","tracking":"1","ajaxurl":"https:\/\/www.drugtargetreview.com\/wp-admin\/admin-ajax.php","security":"ee95125644","action":"wpa_stats_action","url":"https:\/\/www.drugtargetreview.com\/article\/104912\/drug-target-review-issue-3-2022\/","post_id":"104912"}; /* ]]> */ </script> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-content/plugins/wp-accessibility/js/wp-accessibility.min.js?ver=1.7.6" id="wp-accessibility-js"></script> <script type="text/javascript" src="https://cdn.onesignal.com/sdks/OneSignalSDK.js?ver=1.0.0" id="remote_sdk-js" async="async" data-wp-strategy="async"></script> <script type="text/javascript" src="https://www.drugtargetreview.com/wp-includes/js/comment-reply.min.js?ver=62f62f3de500b9c925887338eccd4afd" id="comment-reply-js" async="async" data-wp-strategy="async"></script> <script> jQuery( function( $ ) { $( '#mtphr-dnt-56707' ).ditty_news_ticker({ id : '56707', type : 'scroll', scroll_direction : 'left', scroll_speed : 10, scroll_pause : 1, scroll_spacing : 100, scroll_init : 0, scroll_init_delay : 2, rotate_type : 'fade', auto_rotate : 1, rotate_delay : 7, rotate_pause : 0, rotate_speed : 10, rotate_ease : 'easeInOutQuint', nav_reverse : 0, disable_touchswipe : 0, offset : 40, after_load : function( $ticker ) { }, before_change : function( $ticker ) { }, after_change : function( $ticker ) { } }); }); </script> <script type="text/javascript"> CLI_ACCEPT_COOKIE_EXPIRE = 182; </script> <script>window.advads_admin_bar_items = [];</script><script>!function(){window.advanced_ads_ready_queue=window.advanced_ads_ready_queue||[],advanced_ads_ready_queue.push=window.advanced_ads_ready;for(var d=0,a=advanced_ads_ready_queue.length;d<a;d++)advanced_ads_ready(advanced_ads_ready_queue[d])}();</script><script type="text/javascript">(function() { var po = document.createElement('script'); po.type = 'text/javascript'; po.async=true;; po.src = 'https://www.drugtargetreview.com/wp-content/plugins/easy-social-share-buttons3/lib/modules/conversions-pro/assets/share-conversions-tracker.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(po, s); })();(function() { var po = document.createElement('script'); po.type = 'text/javascript'; po.async=true;; po.src = 'https://www.drugtargetreview.com/wp-content/plugins/easy-social-share-buttons3/assets/modules/pinterest-pro.min.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(po, s); })();(function() { var po = document.createElement('script'); po.type = 'text/javascript'; po.async=true;; po.src = 'https://www.drugtargetreview.com/wp-content/plugins/easy-social-share-buttons3/assets/modules/subscribe-forms.min.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(po, s); })();(function() { var po = document.createElement('script'); po.type = 'text/javascript'; po.async=true;; po.src = 'https://www.drugtargetreview.com/wp-content/plugins/easy-social-share-buttons3/assets/js/essb-core.min.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(po, s); })();</script><script type="text/javascript">var essb_handle_stats = function(oService, oPostID, oInstance) { var element = jQuery('.essb_'+oInstance); var instance_postion = jQuery(element).attr("data-essb-position") || ""; var instance_template = jQuery(element).attr("data-essb-template") || ""; var instance_button = jQuery(element).attr("data-essb-button-style") || ""; var instance_counters = jQuery(element).hasClass("essb_counters") ? true : false; var instance_nostats = jQuery(element).hasClass("essb_nostats") ? true : false; if (instance_nostats) { return; } var instance_mobile = false; if( (/Android|webOS|iPhone|iPad|iPod|BlackBerry|IEMobile|Opera Mini/i).test(navigator.userAgent) ) { instance_mobile = true; } if (typeof(essb_settings) != "undefined") { jQuery.post(essb_settings.ajax_url, { 'action': 'essb_stat_log', 'post_id': oPostID, 'service': oService, 'template': instance_template, 'mobile': instance_mobile, 'position': instance_postion, 'button': instance_button, 'counter': instance_counters, 'nonce': essb_settings.essb3_nonce }, function (data) { if (data) { }},'json'); } }; var essb_log_stats_only = function(service, postId, position) { var instance_mobile = false; if( (/Android|webOS|iPhone|iPad|iPod|BlackBerry|IEMobile|Opera Mini/i).test(navigator.userAgent) ) { instance_mobile = true; } if (typeof(essb_settings) != "undefined") { jQuery.post(essb_settings.ajax_url, { 'action': 'essb_stat_log', 'post_id': postId, 'service': service, 'template': position, 'mobile': instance_mobile, 'position': position, 'button': position, 'counter': false, 'nonce': essb_settings.essb3_nonce }, function (data) { if (data) { }},'json'); } };var essb_clicked_lovethis = window.essb_clicked_lovethis = false; var essb_love_you_message_thanks = window.essb_love_you_message_thanks = "Thank you for loving this."; var essb_love_you_message_loved = window.essb_love_you_message_loved = "You already love this today.";</script><script id="drugt-tracking">var advads_tracking_ads = {};var advads_tracking_urls = {"1":"https:\/\/www.drugtargetreview.com\/wp-admin\/admin-ajax.php"};var advads_tracking_methods = {"1":"ga"};var advads_tracking_parallel = {"1":false};var advads_tracking_linkbases = {"1":"https:\/\/www.drugtargetreview.com\/linkout\/"};var advads_gatracking_uids = {"1":["G-Z25Z9J71CW"]};var advads_gatracking_allads = {"1":{"154050":{"title":"Webinar - Editorial - 25 November 2024","target":"https:\/\/www.drugtargetreview.com\/webinar\/153145\/overcoming-critical-challenges-in-ai-driven-drug-discovery\/?zcs=AdvancedAd&campaign_source=AdvancedAd&utm_medium=email&utm_source=content&utm_campaign=Overcoming%20critical%20challenges%20in%20AI-driven%20drug%20discovery%2025%20Nov%2024","impression":true,"click":true},"153973":{"title":"Beyond the lab: Antibodies","target":"https:\/\/www.drugtargetreview.com\/whitepaper\/153630\/beyond-the-lab-antibodies\/?zcs=AdvancedAd&campaign_source=AdvancedAd&utm_medium=website&utm_source=advanced%20ad&utm_campaign=Beyond%20the%20Lab%20report%2024%20Oct%2024","impression":true,"click":true},"153565":{"title":"DTR - Molecular Devices - Podcast Episode 11 - 2024","target":"https:\/\/www.drugtargetreview.com\/podcasts\/scaling-genetic-medicine-with-trna\/?utm_source=advanced_ad&utm_medium_source=referral&utm_campaign=advanced_ad_podcast_ep_11","impression":true,"click":true},"151891":{"title":"Eurofins - 2 October 2024","target":"","impression":true,"click":true},"110806":{"title":"Webinar - Eurofins 14 September 2023","target":"https:\/\/www.drugtargetreview.com\/webinar\/110926\/functional-assays-for-the-development-of-agonistic-antibodies\/?zcs=AdvancedAd&campaign_source=AdvancedAd","impression":true,"click":true},"110191":{"title":"ELRIG - Competition 2023 (copy)","target":"","impression":true,"click":true},"109998":{"title":"ebook - Sartorius - 22 May 2023","target":"https:\/\/www.drugtargetreview.com\/article\/109708\/ebook-advances-in-cell-imaging-and-retrieval\/?zcs=AdvancedAd&campaign_source=AdvancedAd","impression":true,"click":true},"109973":{"title":"Webinar - CN Bio 28 June 2023","target":"https:\/\/www.drugtargetreview.com\/webinar\/109935\/normalization-of-organ-on-a-chip-samples-for-mass-spectrometry-based-proteomics-and-metabolomics-via-dansylation-based-assay\/?zcs=AdvancedAd&campaign_source=AdvancedAd","impression":true,"click":true},"109969":{"title":"ELRIG - Competition 2023","target":"","impression":true,"click":true},"109607":{"title":"App note - Halo Labs - Issue 1 2023","target":"","impression":true,"click":true},"109298":{"title":"ebook - Sartorius - 17 April 2023","target":"https:\/\/www.drugtargetreview.com\/article\/109018\/ebook-never-miss-a-hit-unleash-your-drug-discovery-with-a-label-free-playlist\/?zcs=AdvancedAd&campaign_source=AdvancedAd","impression":true,"click":true},"109207":{"title":"Webinar - Catalent 30 May 2023","target":"https:\/\/www.drugtargetreview.com\/webinar\/109152\/cgmp-compliant-ipsc-manufacturing-and-development-of-differentiated-cells-for-advanced-therapies-strategies-and-challenges\/?zcs=AdvancedAd&campaign_source=AdvancedAd","impression":true,"click":true},"109116":{"title":"Webinar - Genscript ProBio 3 May 2023","target":"https:\/\/www.drugtargetreview.com\/webinar\/109099\/accelerating-biologics-discovery-via-antibody-library-and-reaching-ind-faster-with-cell-line-development\/?zcs=AdvancedAd&campaign_source=AdvancedAd","impression":true,"click":true},"109037":{"title":"Podcast - Mol Dev - Episode 18","target":"https:\/\/www.drugtargetreview.com\/podcasts\/episode-18-scaling-up-organoids\/","impression":true,"click":true},"108740":{"title":"Webinar - Eurofins 12 October 2023","target":"https:\/\/www.drugtargetreview.com\/webinar\/110968\/sh2-domains-as-a-target-class-in-cancer-and-inflammation\/?zcs=AdvancedAd&campaign_source=AdvancedAd","impression":true,"click":true},"108598":{"title":"Podcast - Mol Dev - Episode 17","target":"https:\/\/www.drugtargetreview.com\/podcasts\/episode-17-imaging-data-analysis-of-organoids\/","impression":true,"click":true},"108234":{"title":"Webinar - Eurofins 6 April 2023","target":"https:\/\/www.drugtargetreview.com\/webinar\/108158\/successful-hit-finding-for-pim3-kinase-inhibitors-from-hts-to-extended-hit-characterisation-including-spectral-shift-technology\/?zcs=AdvancedAd&campaign_source=AdvancedAd","impression":true,"click":true},"108137":{"title":"Webinar - Thermo 2 March 2023","target":"https:\/\/www.drugtargetreview.com\/webinar\/108074\/using-integrative-biophysical-approaches-to-understand-gpcr-regulation-by-%ce%b2-arrestins\/","impression":true,"click":true},"108073":{"title":"Podcast - Mol Dev - 24 January","target":"https:\/\/www.drugtargetreview.com\/podcasts\/episode-16-data-acquisition-of-organoids\/","impression":true,"click":true},"107670":{"title":"[Pop-up] Media Planner 2023 \u2013 Before you go","target":"https:\/\/www.drugtargetreview.com\/advertising-editorial\/?target=Media%20Planner\/Content%20Calendar?zcs=WebsiteBanner&campaign_source=PopUpBanner","impression":true,"click":true},"107484":{"title":"Webinar - Eurofins 22 March 2023","target":"https:\/\/www.drugtargetreview.com\/webinar\/107431\/webinar-validate\u20261-2-therapeutics\/?zcs=AdvancedAd&campaign_source=AdvancedAd","impression":true,"click":true},"107114":{"title":"Podcast - Mol Dev - 7 December","target":"https:\/\/www.drugtargetreview.com\/podcasts\/episode-15-minimise-variability-issues-in-your-organoids\/","impression":true,"click":true},"107097":{"title":"SPT Labtech - 13 December 2022 Webinar V2","target":"https:\/\/www.drugtargetreview.com\/webinar\/105712\/making-transfers-of-crystallisation-screens-more-consistent-reliable-and-reproducible\/?zcs=AdvancedAd&campaign_source=AdvancedAd","impression":true,"click":true},"106340":{"title":"Unchained Labs - 16 November 2022 Webinar V2","target":"https:\/\/www.drugtargetreview.com\/webinar\/105567\/power-up-your-lnp-and-aav-sample-prep-with-unagi\/?zcs=AdvancedAd&campaign_source=AdvancedAd","impression":true,"click":true},"106186":{"title":"Podcast - Mol Dev - 1 November 2022","target":"https:\/\/www.drugtargetreview.com\/podcasts\/episode-14-complex-assays-with-ian-shoemaker-beckman-coulter-life-sciences-dr-oksana-sirenko-molecular-devices\/","impression":true,"click":true},"106172":{"title":"Fluidigm - 30 November 2022 Webinar","target":"https:\/\/www.drugtargetreview.com\/webinar\/106023\/translating-complex-high-parameter-immune-data-from-clinical-samples-into-actionable-disease-insights\/?zcs=AdvancedAd&campaign_source=AdvancedAd","impression":true,"click":true},"106066":{"title":"SPT Labtech - 13 December 2022 Webinar","target":"https:\/\/www.drugtargetreview.com\/webinar\/105712\/making-transfers-of-crystallisation-screens-more-consistent-reliable-and-reproducible\/?zcs=AdvancedAd&campaign_source=AdvancedAd","impression":true,"click":true},"106018":{"title":"Takara Bio - ebook - October 2022","target":"https:\/\/www.drugtargetreview.com\/whitepaper\/105651\/ebook-current-and-emerging-strategies-for-engineered-cell-therapies-cancer-immunotherapy\/?zcs=AdvancedAd&campaign_source=AdvancedAd","impression":true,"click":true},"106016":{"title":"Bio-Rad - Survey September 2022 - V3 (copy)","target":"https:\/\/www.surveymonkey.co.uk\/r\/K6Q6BRG","impression":true,"click":true},"105961":{"title":"[Pop-up] Amazon Rainforest DTR Survey","target":"https:\/\/www.surveymonkey.co.uk\/r\/MJ8F7BH","impression":true,"click":true},"105915":{"title":"Cytiva - 7 December 2022 Webinar","target":"https:\/\/www.drugtargetreview.com\/webinar\/105785\/a-novel-serum-free-culture-media-for-improved-car-t-cell-manufacturing\/?zcs=AdvancedAd&campaign_source=AdvancedAd","impression":true,"click":true},"105880":{"title":"Bio-Rad - Survey September 2022 - V3","target":"https:\/\/www.surveymonkey.co.uk\/r\/K6Q6BRG","impression":true,"click":true},"105704":{"title":"Eurofins - 20 October 2022 Webinar V2","target":"https:\/\/www.drugtargetreview.com\/webinar\/104692\/decoding-cancer-and-inflammation-identifying-selective-inhibitors-of-sh2-domains\/?zcs=AdvancedAd&campaign_source=AdvancedAd","impression":true,"click":true},"105671":{"title":"Unchained Labs - 16 November 2022 Webinar","target":"https:\/\/www.drugtargetreview.com\/webinar\/105567\/power-up-your-lnp-and-aav-sample-prep-with-unagi\/?zcs=AdvancedAd&campaign_source=AdvancedAd","impression":true,"click":true},"105540":{"title":"Podcast - Leica - 28 September 2022","target":"https:\/\/www.drugtargetreview.com\/podcasts\/episode-13-multiplexing-with-dr-luke-gammon-queen-mary-university-dr-david-pointu-leica-microsystems\/","impression":true,"click":true},"105330":{"title":"[Pop-up] Survey - Bio-Rad - September 2022","target":"https:\/\/www.surveymonkey.co.uk\/r\/LH3F6CD","impression":true,"click":true},"105258":{"title":"Bio-Rad - Survey September 2022 - V2","target":"https:\/\/www.surveymonkey.co.uk\/r\/K6Q6BRG","impression":true,"click":true},"104987":{"title":"Podcast - Mol Dev - 12 September 2022","target":"https:\/\/www.drugtargetreview.com\/podcasts\/episode-12-elisa-assays-with-dr-ana-miletic-and-anna-dey-kyowa-kirin-dr-cathy-olsen-molecular-devices\/","impression":true,"click":true},"104864":{"title":"Sartorius - 2 November 2022 Webinar","target":"https:\/\/www.drugtargetreview.com\/webinar\/104778\/cho-targeted-integration-platform-for-accelerated-antibody-development\/?zcs=AdvancedAd&campaign_source=AdvancedAd","impression":true,"click":true},"104862":{"title":"Sartorius - 05 October 2022 Webinar","target":"https:\/\/www.drugtargetreview.com\/webinar\/104600\/engineering-cell-lines-for-rare-disease-research-and-precision-therapeutics\/?zcs=AdvancedAd&campaign_source=AdvancedAd","impression":true,"click":true},"104771":{"title":"Bio-Rad - Survey September 2022","target":"https:\/\/www.surveymonkey.co.uk\/r\/K6Q6BRG","impression":true,"click":true},"104741":{"title":"Eurofins - 20 October 2022 Webinar","target":"https:\/\/www.drugtargetreview.com\/webinar\/104692\/decoding-cancer-and-inflammation-identifying-selective-inhibitors-of-sh2-domains\/?zcs=AdvancedAd&campaign_source=AdvancedAd","impression":true,"click":true},"104646":{"title":"Brooks Automation - 10 August 2022 Webinar (copy)","target":"https:\/\/www.drugtargetreview.com\/webinar\/104600\/engineering-cell-lines-for-rare-disease-research-and-precision-therapeutics\/?zcs=AdvancedAd&campaign_source=AdvancedAd","impression":true,"click":true},"104609":{"title":"Eurofins Discovery - 25 August 2022 Webinar (copy)","target":"https:\/\/www.drugtargetreview.com\/webinar\/103875\/comprehensive-in-vitro-approach-to-evaluate-transporter-mediated-drug-interactions-in-drug-discovery\/?zcs=AdvancedAd&campaign_source=AdvancedAd","impression":true,"click":true},"104460":{"title":"Podcast - Mol Dev - 8 August 2022","target":"https:\/\/www.drugtargetreview.com\/podcasts\/episode-11-crispr-with-dr-jakob-haaber-snipr-biome-dr-richard-fox-infinome-biosciences\/","impression":true,"click":true},"104327":{"title":"Mol Dev - 7 September 2022 Webinar","target":"https:\/\/www.drugtargetreview.com\/webinar\/104232\/how-3d-biology-is-shaping-the-future-of-drug-discovery\/?zcs=AdvancedAd&campaign_source=AdvancedAd","impression":true,"click":true},"104136":{"title":"Eurofins - 28 July 2022 Virtual Panel v2","target":"https:\/\/www.drugtargetreview.com\/webinar\/103255\/roundtable-accelerating-your-therapeutics-development-with-bioassays\/?zcs=AdvancedAd&campaign_source=AdvancedAd","impression":true,"click":true},"104012":{"title":"Podcast - Leica - 7 July 2022","target":"https:\/\/www.drugtargetreview.com\/podcasts\/episode-10-microscopy-in-neuroscience-with-dr-tobi-langenhan-leipzig-university-dr-abdullah-ahmed-leica-microsystems\/","impression":true,"click":true},"103973":{"title":"Eurofins - 14 July 2022 Webinar - V2","target":"https:\/\/www.drugtargetreview.com\/webinar\/102880\/leveraging-the-e3scantm-technology-platform-for-next-generation-targeted-protein-degradation\/?zcs=AdvancedAd&campaign_source=AdvancedAd","impression":true,"click":true},"103929":{"title":"Eurofins Discovery - 25 August 2022 Webinar","target":"https:\/\/www.drugtargetreview.com\/webinar\/103875\/comprehensive-in-vitro-approach-to-evaluate-transporter-mediated-drug-interactions-in-drug-discovery\/?zcs=AdvancedAd&campaign_source=AdvancedAd","impression":true,"click":true},"103911":{"title":"Brooks Automation - 10 August 2022 Webinar","target":"https:\/\/www.drugtargetreview.com\/webinar\/103876\/how-robotics-enable-process-automation-in-the-modern-laboratory\/?zcs=AdvancedAd&campaign_source=AdvancedAd","impression":true,"click":true},"103726":{"title":"Podcast - Bio-Rad - 17 June 2022","target":"https:\/\/www.drugtargetreview.com\/podcasts\/episode-9-rdna-detection-with-dr-jorge-haller-prevail-therapeutics-dr-mark-white-bio-rad\/","impression":true,"click":true},"103383":{"title":"bit.bio - 29 June 2022","target":"https:\/\/www.drugtargetreview.com\/webinar\/103231\/improving-huntingtons-disease-drug-discovery-with-new-reproducible-disease-models\/?zcs=AdvancedAd&campaign_source=AdvancedAd","impression":true,"click":true},"103205":{"title":"[Pop-up] Subscribe Banner","target":"https:\/\/www.drugtargetreview.com\/zmember\/subscribers\/register_new","impression":true,"click":true},"100639":{"title":"Thermo Fisher Podcast - 20 December 2021","target":"https:\/\/www.drugtargetreview.com\/podcast\/100338\/episode-4-lims-systems-with-tyler-pascoe-matt-gruver-thermo-fisher-scientific\/","impression":true,"click":true},"98973":{"title":"Takara Bio - 14 December 2021 - Webinar","target":"","impression":true,"click":true},"95686":{"title":"Audience Development Report 11 August 2021 - Generic Launch","target":"https:\/\/www.drugtargetreview.com\/article\/92497\/ai-informatics-drug-discovery\/?campaign_source=AdvancedAdGeneric","impression":true,"click":true},"95163":{"title":"DTR - Online Summit 2021 - Agenda Session 1 Day 1","target":"https:\/\/bit.ly\/3eXXyY3","impression":true,"click":true},"89919":{"title":"IDBS webinar - 20 May 2021: Realise the true power of your online, atline and offline biologics data","target":"","impression":true,"click":true},"58586":{"title":"COVID-19 research hub","target":"https:\/\/www.drugtargetreview.com\/research_hub\/covid-19\/","impression":true,"click":true},"42536":{"title":"[Ad Butler] Sidebar #3 - Mobile","target":"","impression":true,"click":true},"44209":{"title":"Webinar (Sartorius) A high-throughput approach to developing T-cell immunotherapies","target":"https:\/\/attendee.gotowebinar.com\/register\/3221421033967980555?source=Advanced+Ad","impression":true,"click":true},"42537":{"title":"[Ad Butler] Sidebar 300x100 - Mobile","target":"","impression":true,"click":true},"30044":{"title":"[Ad Butler] Super Leaderboard - Fallback #1","target":"","impression":true,"click":true},"30029":{"title":"[Ad Butler] Leaderboard - Fallback #2","target":"","impression":true,"click":true},"30043":{"title":"[Ad Butler] Super Leaderboard","target":"","impression":true,"click":true},"30028":{"title":"[Ad Butler] Leaderboard - Fallback #1","target":"","impression":true,"click":true},"30027":{"title":"[Ad Butler] Leaderboard","target":"","impression":true,"click":true},"30042":{"title":"[Ad Butler] Sidebar 300x100 - Desktop","target":"","impression":true,"click":true},"35405":{"title":"[Ad Butler] Fixed Footer \u2013 Fallback #1","target":"","impression":true,"click":true},"30026":{"title":"[Ad Butler] Fixed Footer - Leaderboard","target":"","impression":true,"click":true},"35406":{"title":"[Ad Butler] Fixed Footer \u2013 Fallback #2","target":"","impression":true,"click":true},"30602":{"title":"[In-page] Merck - SPLASH Lipidomix","target":"https:\/\/www.sigmaaldrich.com\/catalog\/product\/avanti\/330707?&utm_source=drug%20target%20review&utm_medium=product%20listing&utm_campaign=oscar-tid-2017011098","impression":true,"click":true},"30036":{"title":"[Ad Butler] Sidebar #4","target":"","impression":true,"click":true},"30046":{"title":"[Ad Butler] Super Leaderboard - Fallback #3","target":"","impression":true,"click":true},"30045":{"title":"[Ad Butler] Super Leaderboard - Fallback #2","target":"","impression":true,"click":true},"30040":{"title":"[Ad Butler] Sidebar #6","target":"","impression":true,"click":true},"30038":{"title":"[Ad Butler] Sidebar #5","target":"","impression":true,"click":true},"30025":{"title":"[Ad Butler] Fixed Footer - Super Leaderboard","target":"","impression":true,"click":true}}};var advads_gatracking_anonym = false;var advads_gatracking_transmitpageqs = {};</script>   <script src="//rum-static.pingdom.net/pa-606c3b17365abb0011000159.js" async></script>  <script> window.onscroll = function() {myFunction()}; var skyscraper = document.getElementById("skyscraperBespoke"); var sticky = skyscraper.offsetTop; function myFunction() { if (window.pageYOffset > sticky) { skyscraper.classList.add("sticky"); } else { skyscraper.classList.remove("sticky"); } } </script> <script data-no-optimize="1">!function(t,e){"object"==typeof exports&&"undefined"!=typeof module?module.exports=e():"function"==typeof define&&define.amd?define(e):(t="undefined"!=typeof globalThis?globalThis:t||self).LazyLoad=e()}(this,function(){"use strict";function e(){return(e=Object.assign||function(t){for(var e=1;e<arguments.length;e++){var n,a=arguments[e];for(n in a)Object.prototype.hasOwnProperty.call(a,n)&&(t[n]=a[n])}return t}).apply(this,arguments)}function i(t){return e({},it,t)}function o(t,e){var n,a="LazyLoad::Initialized",i=new t(e);try{n=new CustomEvent(a,{detail:{instance:i}})}catch(t){(n=document.createEvent("CustomEvent")).initCustomEvent(a,!1,!1,{instance:i})}window.dispatchEvent(n)}function l(t,e){return t.getAttribute(gt+e)}function c(t){return l(t,bt)}function s(t,e){return function(t,e,n){e=gt+e;null!==n?t.setAttribute(e,n):t.removeAttribute(e)}(t,bt,e)}function r(t){return s(t,null),0}function u(t){return null===c(t)}function d(t){return c(t)===vt}function f(t,e,n,a){t&&(void 0===a?void 0===n?t(e):t(e,n):t(e,n,a))}function _(t,e){nt?t.classList.add(e):t.className+=(t.className?" ":"")+e}function v(t,e){nt?t.classList.remove(e):t.className=t.className.replace(new RegExp("(^|\\s+)"+e+"(\\s+|$)")," ").replace(/^\s+/,"").replace(/\s+$/,"")}function g(t){return t.llTempImage}function b(t,e){!e||(e=e._observer)&&e.unobserve(t)}function p(t,e){t&&(t.loadingCount+=e)}function h(t,e){t&&(t.toLoadCount=e)}function n(t){for(var e,n=[],a=0;e=t.children[a];a+=1)"SOURCE"===e.tagName&&n.push(e);return n}function m(t,e){(t=t.parentNode)&&"PICTURE"===t.tagName&&n(t).forEach(e)}function a(t,e){n(t).forEach(e)}function E(t){return!!t[st]}function I(t){return t[st]}function y(t){return delete t[st]}function A(e,t){var n;E(e)||(n={},t.forEach(function(t){n[t]=e.getAttribute(t)}),e[st]=n)}function k(a,t){var i;E(a)&&(i=I(a),t.forEach(function(t){var e,n;e=a,(t=i[n=t])?e.setAttribute(n,t):e.removeAttribute(n)}))}function L(t,e,n){_(t,e.class_loading),s(t,ut),n&&(p(n,1),f(e.callback_loading,t,n))}function w(t,e,n){n&&t.setAttribute(e,n)}function x(t,e){w(t,ct,l(t,e.data_sizes)),w(t,rt,l(t,e.data_srcset)),w(t,ot,l(t,e.data_src))}function O(t,e,n){var a=l(t,e.data_bg_multi),i=l(t,e.data_bg_multi_hidpi);(a=at&&i?i:a)&&(t.style.backgroundImage=a,n=n,_(t=t,(e=e).class_applied),s(t,ft),n&&(e.unobserve_completed&&b(t,e),f(e.callback_applied,t,n)))}function N(t,e){!e||0<e.loadingCount||0<e.toLoadCount||f(t.callback_finish,e)}function C(t,e,n){t.addEventListener(e,n),t.llEvLisnrs[e]=n}function M(t){return!!t.llEvLisnrs}function z(t){if(M(t)){var e,n,a=t.llEvLisnrs;for(e in a){var i=a[e];n=e,i=i,t.removeEventListener(n,i)}delete t.llEvLisnrs}}function R(t,e,n){var a;delete t.llTempImage,p(n,-1),(a=n)&&--a.toLoadCount,v(t,e.class_loading),e.unobserve_completed&&b(t,n)}function T(o,r,c){var l=g(o)||o;M(l)||function(t,e,n){M(t)||(t.llEvLisnrs={});var a="VIDEO"===t.tagName?"loadeddata":"load";C(t,a,e),C(t,"error",n)}(l,function(t){var e,n,a,i;n=r,a=c,i=d(e=o),R(e,n,a),_(e,n.class_loaded),s(e,dt),f(n.callback_loaded,e,a),i||N(n,a),z(l)},function(t){var e,n,a,i;n=r,a=c,i=d(e=o),R(e,n,a),_(e,n.class_error),s(e,_t),f(n.callback_error,e,a),i||N(n,a),z(l)})}function G(t,e,n){var a,i,o,r,c;t.llTempImage=document.createElement("IMG"),T(t,e,n),E(c=t)||(c[st]={backgroundImage:c.style.backgroundImage}),o=n,r=l(a=t,(i=e).data_bg),c=l(a,i.data_bg_hidpi),(r=at&&c?c:r)&&(a.style.backgroundImage='url("'.concat(r,'")'),g(a).setAttribute(ot,r),L(a,i,o)),O(t,e,n)}function D(t,e,n){var a;T(t,e,n),a=e,e=n,(t=It[(n=t).tagName])&&(t(n,a),L(n,a,e))}function V(t,e,n){var a;a=t,(-1<yt.indexOf(a.tagName)?D:G)(t,e,n)}function F(t,e,n){var a;t.setAttribute("loading","lazy"),T(t,e,n),a=e,(e=It[(n=t).tagName])&&e(n,a),s(t,vt)}function j(t){t.removeAttribute(ot),t.removeAttribute(rt),t.removeAttribute(ct)}function P(t){m(t,function(t){k(t,Et)}),k(t,Et)}function S(t){var e;(e=At[t.tagName])?e(t):E(e=t)&&(t=I(e),e.style.backgroundImage=t.backgroundImage)}function U(t,e){var n;S(t),n=e,u(e=t)||d(e)||(v(e,n.class_entered),v(e,n.class_exited),v(e,n.class_applied),v(e,n.class_loading),v(e,n.class_loaded),v(e,n.class_error)),r(t),y(t)}function $(t,e,n,a){var i;n.cancel_on_exit&&(c(t)!==ut||"IMG"===t.tagName&&(z(t),m(i=t,function(t){j(t)}),j(i),P(t),v(t,n.class_loading),p(a,-1),r(t),f(n.callback_cancel,t,e,a)))}function q(t,e,n,a){var i,o,r=(o=t,0<=pt.indexOf(c(o)));s(t,"entered"),_(t,n.class_entered),v(t,n.class_exited),i=t,o=a,n.unobserve_entered&&b(i,o),f(n.callback_enter,t,e,a),r||V(t,n,a)}function H(t){return t.use_native&&"loading"in HTMLImageElement.prototype}function B(t,i,o){t.forEach(function(t){return(a=t).isIntersecting||0<a.intersectionRatio?q(t.target,t,i,o):(e=t.target,n=t,a=i,t=o,void(u(e)||(_(e,a.class_exited),$(e,n,a,t),f(a.callback_exit,e,n,t))));var e,n,a})}function J(e,n){var t;et&&!H(e)&&(n._observer=new IntersectionObserver(function(t){B(t,e,n)},{root:(t=e).container===document?null:t.container,rootMargin:t.thresholds||t.threshold+"px"}))}function K(t){return Array.prototype.slice.call(t)}function Q(t){return t.container.querySelectorAll(t.elements_selector)}function W(t){return c(t)===_t}function X(t,e){return e=t||Q(e),K(e).filter(u)}function Y(e,t){var n;(n=Q(e),K(n).filter(W)).forEach(function(t){v(t,e.class_error),r(t)}),t.update()}function t(t,e){var n,a,t=i(t);this._settings=t,this.loadingCount=0,J(t,this),n=t,a=this,Z&&window.addEventListener("online",function(){Y(n,a)}),this.update(e)}var Z="undefined"!=typeof window,tt=Z&&!("onscroll"in window)||"undefined"!=typeof navigator&&/(gle|ing|ro)bot|crawl|spider/i.test(navigator.userAgent),et=Z&&"IntersectionObserver"in window,nt=Z&&"classList"in document.createElement("p"),at=Z&&1<window.devicePixelRatio,it={elements_selector:".lazy",container:tt||Z?document:null,threshold:300,thresholds:null,data_src:"src",data_srcset:"srcset",data_sizes:"sizes",data_bg:"bg",data_bg_hidpi:"bg-hidpi",data_bg_multi:"bg-multi",data_bg_multi_hidpi:"bg-multi-hidpi",data_poster:"poster",class_applied:"applied",class_loading:"litespeed-loading",class_loaded:"litespeed-loaded",class_error:"error",class_entered:"entered",class_exited:"exited",unobserve_completed:!0,unobserve_entered:!1,cancel_on_exit:!0,callback_enter:null,callback_exit:null,callback_applied:null,callback_loading:null,callback_loaded:null,callback_error:null,callback_finish:null,callback_cancel:null,use_native:!1},ot="src",rt="srcset",ct="sizes",lt="poster",st="llOriginalAttrs",ut="loading",dt="loaded",ft="applied",_t="error",vt="native",gt="data-",bt="ll-status",pt=[ut,dt,ft,_t],ht=[ot],mt=[ot,lt],Et=[ot,rt,ct],It={IMG:function(t,e){m(t,function(t){A(t,Et),x(t,e)}),A(t,Et),x(t,e)},IFRAME:function(t,e){A(t,ht),w(t,ot,l(t,e.data_src))},VIDEO:function(t,e){a(t,function(t){A(t,ht),w(t,ot,l(t,e.data_src))}),A(t,mt),w(t,lt,l(t,e.data_poster)),w(t,ot,l(t,e.data_src)),t.load()}},yt=["IMG","IFRAME","VIDEO"],At={IMG:P,IFRAME:function(t){k(t,ht)},VIDEO:function(t){a(t,function(t){k(t,ht)}),k(t,mt),t.load()}},kt=["IMG","IFRAME","VIDEO"];return t.prototype={update:function(t){var e,n,a,i=this._settings,o=X(t,i);{if(h(this,o.length),!tt&&et)return H(i)?(e=i,n=this,o.forEach(function(t){-1!==kt.indexOf(t.tagName)&&F(t,e,n)}),void h(n,0)):(t=this._observer,i=o,t.disconnect(),a=t,void i.forEach(function(t){a.observe(t)}));this.loadAll(o)}},destroy:function(){this._observer&&this._observer.disconnect(),Q(this._settings).forEach(function(t){y(t)}),delete this._observer,delete this._settings,delete this.loadingCount,delete this.toLoadCount},loadAll:function(t){var e=this,n=this._settings;X(t,n).forEach(function(t){b(t,e),V(t,n,e)})},restoreAll:function(){var e=this._settings;Q(e).forEach(function(t){U(t,e)})}},t.load=function(t,e){e=i(e);V(t,e)},t.resetStatus=function(t){r(t)},Z&&function(t,e){if(e)if(e.length)for(var n,a=0;n=e[a];a+=1)o(t,n);else o(t,e)}(t,window.lazyLoadOptions),t});!function(e,t){"use strict";function a(){t.body.classList.add("litespeed_lazyloaded")}function n(){console.log("[LiteSpeed] Start Lazy Load Images"),d=new LazyLoad({elements_selector:"[data-lazyloaded]",callback_finish:a}),o=function(){d.update()},e.MutationObserver&&new MutationObserver(o).observe(t.documentElement,{childList:!0,subtree:!0,attributes:!0})}var d,o;e.addEventListener?e.addEventListener("load",n,!1):e.attachEvent("onload",n)}(window,document);</script><script>(function(){function c(){var b=a.contentDocument||a.contentWindow.document;if(b){var d=b.createElement('script');d.innerHTML="window.__CF$cv$params={r:'8e74879858479c2d',t:'MTczMjQwMDI1MC4wMDAwMDA='};var a=document.createElement('script');a.nonce='';a.src='/cdn-cgi/challenge-platform/scripts/jsd/main.js';document.getElementsByTagName('head')[0].appendChild(a);";b.getElementsByTagName('head')[0].appendChild(d)}}if(document.body){var a=document.createElement('iframe');a.height=1;a.width=1;a.style.position='absolute';a.style.top=0;a.style.left=0;a.style.border='none';a.style.visibility='hidden';document.body.appendChild(a);if('loading'!==document.readyState)c();else if(window.addEventListener)document.addEventListener('DOMContentLoaded',c);else{var e=document.onreadystatechange||function(){};document.onreadystatechange=function(b){e(b);'loading'!==document.readyState&&(document.onreadystatechange=e,c())}}}})();</script></body> </html>

CINXE.COM

Drug Target Review – Issue 3 2022