Macrophage Cell Biology from Development to Dysfunction in I

<!doctype html> <html lang="te"> <head> <meta charset="utf-8"> <meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"> <title>Macrophage Cell Biology from Development to Dysfunction in I | 110549</title> <meta name="keywords" content="Harriet Langford, Callum Hargrove, Isla Pendleton, Rowan Tinsley, Beatrix Hammond, "/> <meta name="description" content="Macrophages are fundamental components of the immune system, orchestrating responses to pathogens, maintaining tissue integrity, and mediating repair p..110549"/> <meta name="citation_publisher" content="హిలారిస్ SRL" /> <meta name="citation_journal_title" content="జర్నల్ ఆఫ్ ఇమ్యునోబయాలజీ"> <meta name="citation_title" content="Macrophage Cell Biology from Development to Dysfunction in Inflammatory Diseases"> <meta name="citation_author" content="Harriet Langford" /> <meta name="citation_author" content="Callum Hargrove" /> <meta name="citation_author" content="Isla Pendleton" /> <meta name="citation_author" content="Rowan Tinsley" /> <meta name="citation_author" content="Beatrix Hammond" /> <meta name="citation_year" content=""> <meta name="citation_volume" content="9"> <meta name="citation_issue" content="3"> <meta name="citation_abstract" content="Macrophages are fundamental components of the immune system, orchestrating responses to pathogens, maintaining tissue integrity, and mediating repair processes. These versatile cells arise from yolk sac progenitors or monocyte precursors, differentiating into tissue-resident macrophages influenced by local microenvironments. Their functional diversity enables macrophages to adopt specific roles, ranging from pathogen clearance to the regulation of inflammation. In inflammatory diseases, such as rheumatoid arthritis, atherosclerosis, and inflammatory bowel disease, macrophage dysfunction has emerged as a critical driver of pathogenesis. Dysregulation of their polarization into pro-inflammatory (M1) or anti-inflammatory (M2) phenotypes contributes to chronic inflammation and tissue damage. Additionally, alterations in macrophage metabolism and epigenetic profiles further exacerbate their pathological roles, disrupting the delicate balance required for immune homeostasis. Recent advancements in macrophage-targeted therapies, including strategies for functional modulation and reprogramming, are highlighted as promising approaches to mitigate inflammation-driven damage and restore immune balance. Understanding these processes offers critical insights into innovative therapeutic strategies for treating inflammatory diseases."> <meta name="citation_abstract_html_url" content="https://telugu.hilarispublisher.com/abstract/macrophage-cell-biology-from-development-to-dysfunction-in-inflammatory-diseases-110549.html">  <link rel="alternate" href="https://telugu.hilarispublisher.com/abstract/macrophage-cell-biology-from-development-to-dysfunction-in-inflammatory-diseases-110549.html" hreflang="te-in"/> <link rel="canonical" href="https://telugu.hilarispublisher.com/abstract/macrophage-cell-biology-from-development-to-dysfunction-in-inflammatory-diseases-110549.html"> <meta name="google-site-verification" content="oWMEafdcaiOzLHBHrMgGBwtQrvUtl_diAl2cELZt1Ks" /> <meta name="ROBOTS" content="INDEX,FOLLOW"> <meta name="googlebot" content="INDEX,FOLLOW"> <link rel="stylesheet" href="https://stackpath.bootstrapcdn.com/bootstrap/4.4.1/css/bootstrap.min.css"> <link rel="stylesheet" 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<div class="col-lg col-md"> <h1 class="h2 text-primary">జర్నల్ ఆఫ్ ఇమ్యునోబయాలజీ</h1> <div class="row"> <div class="col"> <p class="mb-1">ISSN: 2476-1966 </p> </div> <div class="col"> అందరికి ప్రవేశం </div> <div class="nav-item dropdown multi_lang j_multi_lang"> <a class="nav-link dropdown-toggle" href="#" id="multi_lang" role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false">Language</a> <div class="dropdown-menu" aria-labelledby=""> <a class="dropdown-item" href="https://www.hilarispublisher.com/abstract/macrophage-cell-biology-from-development-to-dysfunction-in-inflammatory-diseases-110549.html" title="English"> <img src="https://www.hilarispublisher.com/admin/flags/usa.png">English </a> <a class="dropdown-item" href="https://spanish.hilarispublisher.com/abstract/macrophage-cell-biology-from-development-to-dysfunction-in-inflammatory-diseases-110549.html" title="Spanish"> <img src="https://www.hilarispublisher.com/admin/flags/spain.png">Spanish </a> <a 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class="container"> <div class="row"> <div class="col-sm"> <h2>Macrophage Cell Biology from Development to Dysfunction in Inflammatory Diseases</h2> <h3>Abstract</h3> <p><i class="fas fa-user"></i> Harriet Langford, Callum Hargrove, Isla Pendleton, Rowan Tinsley, Beatrix Hammond</p> <p><p>Macrophages are fundamental components of the immune system, orchestrating responses to pathogens, maintaining tissue integrity, and mediating repair processes. These versatile cells arise from yolk sac progenitors or monocyte precursors, differentiating into tissue-resident macrophages influenced by local microenvironments. Their functional diversity enables macrophages to adopt specific roles, ranging from pathogen clearance to the regulation of inflammation. In inflammatory diseases, such as rheumatoid arthritis, atherosclerosis, and inflammatory bowel disease, macrophage dysfunction has emerged as a critical driver of pathogenesis. Dysregulation of their polarization into pro-inflammatory (M1) or anti-inflammatory (M2) phenotypes contributes to chronic inflammation and tissue damage. Additionally, alterations in macrophage metabolism and epigenetic profiles further exacerbate their pathological roles, disrupting the delicate balance required for immune homeostasis. Recent advancements in macrophage-targeted therapies, including strategies for functional modulation and reprogramming, are highlighted as promising approaches to mitigate inflammation-driven damage and restore immune balance. Understanding these processes offers critical insights into innovative therapeutic strategies for treating inflammatory diseases.</p></p> <div class="alert alert-info text-left"><b>నిరాకరణ:</b> ఈ సారాంశం ఆర్టిఫిషియల్ ఇంటెలిజెన్స్ టూల్స్ ఉపయోగించి అనువదించబడింది మరియు ఇంకా సమీక్షించబడలేదు లేదా నిర్ధారించబడలేదు</div> <div class="row mt-3"> <div class="col-12 col-sm-auto"> <p class="lead">ఈ కథనాన్ని భాగస్వామ్యం చేయండి</p> </div> <div class="col-12 col-sm-auto"> <div class="nav social-icons"> <a title="ఇక్కడ నొక్కండి" target="_blank" href="https://www.facebook.com/sharer.php?u=https://telugu.hilarispublisher.com/abstract/macrophage-cell-biology-from-development-to-dysfunction-in-inflammatory-diseases-110549.html" class="nav-link bg-facebook fab fa-facebook-f text-white"> </a> <a title="ఇక్కడ నొక్కండి" target="_blank" href="https://twitter.com/share?url=https://telugu.hilarispublisher.com/abstract/macrophage-cell-biology-from-development-to-dysfunction-in-inflammatory-diseases-110549.html" 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