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81%,#0da480 100%); filter: progid:DXImageTransform.Microsoft.gradient( startColorstr='#374581', endColorstr='#0da480',GradientType=1 ); } .topbar-shape:before { content: ""; width: 0px; height: 0px; border-style: solid; border-width: 3px 0 3px 5px; border-color: transparent transparent transparent #0DA480; border-radius: 2px; transform: rotate(0deg); position: absolute; right: -4px; top: 0px; } .topbar-shape:after { content: ""; width: 9px; height: 9px; margin-top: -4px; background-color: #0DA480; position: absolute; transform: rotate(45deg); right: -14px; top: 50%; } .site-header-primary-section-right .header-widget-area { position: absolute; top: 0; right: 0; height: auto; display: flex; column-gap: 35px; row-gap: 15px; padding: 25px 0 0; } .site-header-primary-section-right { position: relative; padding-top: 62px; padding-bottom: 38px; transition: all 0.4s ease; } .site-header-primary-section-right .header-widget-area section { margin: 0; display: flex; } .site-header-primary-section-right .header-widget-area section hr { margin: 0 !important; margin-top: 4px !important; } .site-header-primary-section-right .header-widget-area section p { margin: 0; line-height: 1.2; font-family: 'Archivo', sans-serif; font-weight: 500; } .topBar-info a { text-decoration: underline; color: var(--e-global-color-primary); } .ast-desktop .ast-primary-header-bar .main-header-menu > .menu-item { margin-left: 26px; } .main-header-menu .sub-menu .menu-link { background-color: var(--ast-global-color-1); color: #fff; } .main-header-menu .sub-menu .menu-item:hover .menu-link { color: #fff; opacity: 0.8; } .main-header-menu .sub-menu .menu-item.current-menu-item .menu-link { color: rgba(255,255,255,1); } .main-header-menu .sub-menu { padding: 12px 0; background-color: var(--e-global-color-secondary); width: max-content; max-width: unset; min-width: unset; } .main-header-menu .sub-menu .menu-link { padding-top: 9px; padding-bottom: 9px; } .main-header-menu .sub-menu .menu-link:hover { opacity: 0.9; } .header-social-inner-wrap a, .footer-social-inner-wrap a { transition: all 0.4s ease; } /** Sticky **/ #masthead.sticky .site-logo-img img { width: 90%; } .site-header .header-widget-area figure { margin: 0; padding: 0; } #masthead.sticky { background-color: #fff; position: fixed; box-shadow: 0 3px 6px 0 rgb(0 0 0 / 16%); width: 100%; } .site-header.sticky .site-header-primary-section-left .ast-builder-layout-element .site-branding { padding: 0; } .site-header.sticky .site-header-primary-section-right { padding-top: 50px; padding-bottom: 18px; } /** Sticky /**/ @media (max-width: 1024px) { .site-logo-img img { width: 215px; } .ast-desktop .ast-primary-header-bar .main-header-menu > .menu-item { margin-left: 15px; } .ast-builder-menu-1 .menu-item > .menu-link { font-size: 14px; } } @media (max-width: 921px) { .site-primary-header-wrap { padding: 15px !important; } .site-header-primary-section-right .header-widget-area { display: flex !important; } .ast-primary-header-bar .ast-builder-grid-row { grid-template-columns: auto 1fr; } .topbar-shape { width: 120px; } .ast-button-wrap .menu-toggle.main-header-menu-toggle { padding: 4px; } .site-header-primary-section-right { position: static; } .site-header-primary-section-right .header-widget-area { width: 100%; padding: 15px; justify-content: flex-end; } .site-header-primary-section-right .header-widget-area #block-8 { width: 100px; } .site-header-primary-section-right .header-widget-area #block-11 { width: auto; } .topbar-shape { width: 100%; } .site-header-primary-section-right { padding-top: 0; padding-bottom: 0; } .ast-mobile-header-wrap .ast-above-header-bar { min-height: 12px; } .ast-main-header-wrap .site-header-section { padding: 50px 0 0; } .ast-main-header-wrap .site-branding { padding: 0; } #ast-hf-mobile-menu .sub-menu { padding: 0; } .ast-builder-menu-mobile .main-navigation .menu-item:hover .menu-link { color: #fff; } .ast-builder-menu-mobile .main-navigation .menu-item:hover .ast-menu-toggle path { fill: #fff; } } @media (max-width: 767px) { .site-header-primary-section-right .header-widget-area #block-8 { display: none; } .site-header-primary-section-right .header-widget-area #block-11 { text-align: right; } } /****__ Header __/****/ /****__ Footer __****/ .ast-builder-footer-grid-columns { max-width: 1360px !important; grid-column-gap: 15px; } .ast-builder-grid-row-3-cwide .ast-builder-grid-row { grid-template-columns: 250px 3fr 155px; padding: 0 10px; } .menu-footer-menu-container { display: flex; justify-content: flex-end; padding-right: 40px; } .footer-social-inner-wrap:before { content: "Follow Us"; margin-right: 10px; font-family: 'Archivo', sans-serif; font-size: 16px; font-weight: 400; line-height: 16px; color: #fff; } #menu-footer-menu { display: grid; grid-template-columns: repeat(4, auto); grid-column-gap: 75px; grid-row-gap: 15px; } #menu-footer-menu > li { line-height: 1; } #menu-footer-menu .sub-menu { margin-top: 10px; } #menu-footer-menu > li > a { font-weight: 700; pointer-events: none; } #menu-footer-menu li a { font-size: 14px; } .ast-footer-copyright a { color: #fff!important; } .ast-footer-copyright a:hover { color: var(--e-global-color-accent); } #menu-footer-menu a:hover { color: var(--e-global-color-accent); } #menu-footer-menu .sub-menu .menu-item { padding: 0; line-height: 1; } #menu-footer-menu .sub-menu .menu-item:not(:last-child) { margin-bottom: 8px; } #menu-footer-menu li a:not(:hover) { color: #fff; } @media (max-width: 1180px) { .ast-builder-grid-row-3-cwide .ast-builder-grid-row { grid-template-columns: 205px auto 140px; } #menu-footer-menu { grid-column-gap: 40px; } } @media (max-width: 1024px) { .menu-footer-menu-container { padding-right: 10px; } #menu-footer-menu { grid-column-gap: 25px; } } @media (max-width: 980px) { #menu-footer-menu li a { font-size: 13px; } } @media (max-width: 921px) { .ast-builder-grid-row-3-cwide .ast-builder-grid-row { grid-template-columns: 1fr !important; } .menu-footer-menu-container { justify-content: flex-start; } [data-section="section-fb-social-icons-1"] .footer-social-inner-wrap { text-align: left !important; } .site-footer-primary-section-3 .wp-container-1 { justify-content: flex-start !important; } .ast-footer-copyright { text-align: left !important; } .site-primary-footer-wrap[data-section="section-primary-footer-builder"].ast-footer-row-tablet-stack .site-footer-section { margin-bottom: 30px; } .site-primary-footer-wrap[data-section="section-primary-footer-builder"].ast-footer-row-tablet-stack .site-footer-section:last-child { margin-bottom: 0; } .menu-footer-menu-container { padding-right: 0px; } .site-footer-section-2 { margin-bottom: 45px !important; } .site-footer-section-3 .footer-widget-area { margin-bottom: 0; } } @media (max-width: 580px) { #menu-footer-menu { grid-template-columns: repeat(2, auto); grid-column-gap: 75px; } } /****__ Home page __****/ /**__ Banner __**/ @media (min-width: 1301px) { .homeBanner { min-height: calc(100vh - 138px); position: relative; } } .pageBar--fullH { min-height: calc(100vh - 138px); position: relative; } .homeBanner .elementor-background-video-container video { display: block !important; width: 100% !important; height: 100% !important; object-position: right; } .homeBanner__mVid { display: none !important; z-index: -1; width: 100%; height: 100%; } .homeBanner__button .elementor-button { position: relative; } .homeBanner__button .elementor-button span { z-index: 10; } .homeBanner__button .elementor-button:before { content: ""; width: calc(100% + 16px); height: calc(100% + 4px); background-color: var(--e-global-color-accent ); position: absolute; top: -2px; left: -14px; z-index: 0; transform: scaleX(0.062); transform-origin: left; transition: all 0.4s ease; } .homeBanner__button .elementor-button:hover:before { transform: scaleX(1); } @media (max-width: 1300px) { .homeBanner > .homeBanner__cont > .e-con-inner { padding-top: 160px; padding-bottom: 160px; } } @media (max-width: 1200px) { .homeBanner > .homeBanner__cont > .e-con-inner { padding-top: 100px; padding-bottom: 100px; } } @media (max-width: 1100px) { .homeBanner__title .elementor-heading-title { font-size: 60px !important; } .homeBanner__subTitle .elementor-heading-title { font-size: 38px !important; } } @media (max-width: 1024px) { .homeBanner__cont { height: 100%; display: flex; flex-shrink: 0 !important; flex-grow: 1 !important;` } } @media (max-width: 860px) { .homeBanner .homeBanner__cont > .e-con-inner { padding-top: 64px !important; padding-bottom: 76px !important; } } @media (max-width: 820px) { .homeBanner__title .elementor-heading-title { font-size: 50px !important; } .homeBanner__subTitle .elementor-heading-title { font-size: 32px !important; } } @media (max-width: 767px) { .homeBanner__title .elementor-heading-title { font-size: 46px !important; } .homeBanner__subTitle .elementor-heading-title { font-size: 30px !important; } .homeBanner .homeBanner__cont > .e-con-inner > .elementor-background-video-container { display: block !important; } } @media (max-width: 675px) { .homeBanner__title .elementor-heading-title { font-size: 38px !important; } .homeBanner__subTitle .elementor-heading-title { font-size: 24px !important; } } @media (max-width: 600px) { .homeBanner { min-height: calc(100vh - 138px); } .homeBanner .homeBanner__cont > .e-con-inner { padding-top: 40px !important; padding-bottom: 50px !important; } .homeBanner .homeBanner__cont > .e-con-inner > .elementor-background-video-container { display: none !important; } .homeBanner > .homeBanner__cont > .e-con-inner { flex-direction: column-reverse; } .homeBanner__mVid { display: block !important; } .homeBanner__mVid video { object-position: center !important; } } .homeBanner__title span, .pageBar__title span { color: var(--e-global-color-accent); } /****__ Banner __/****/ .oxGrid__boxInner { height: 100%; justify-content: flex-start; } .oxGrid__boxInner .elementor-widget-button { margin-top: auto; } .oxGrid__boxInner > .e-con-inner { justify-content: flex-start !important; } .oxGrid__boxInner > .e-con-inner .elementor-widget-button { margin-top: auto; } .oxGrid__box { flex-direction: column !important; flex-wrap: nowrap !important; } .oExp__gal .gallery-item { padding: 0 !important; max-width: 100% !important; } .oExp__gal .gallery { margin: 0 !important; display: grid; grid-template-columns: repeat( auto-fit, minmax(196px, auto)); align-items: center; grid-column-gap: 30px; grid-row-gap: 30px; } .pageBar__infoTxt p { margin-bottom: 0; } .pageBar__infoShape .elementor-divider-separator:before { content: ""; width: 0px; height: 0px; border-style: solid; border-width: 4px 0 4px 6px; border-color: transparent transparent transparent var(--e-global-color-accent ); border-radius: 2px; position: absolute; right: -4px; top: -7px; } .pageBar__infoShape .elementor-divider-separator:after { content: ""; width: 9px; height: 9px; margin-top: -7px; background-color: var(--e-global-color-accent ); position: absolute; transform: rotate(45deg); right: -15px; top: 50%; } .pageBar__infoShape .elementor-divider-separator { position: relative; } .oList .elementor-icon-list-icon { transform: rotate(45deg); } @media (max-width: 767px) { .oExp .e-con-inner { display: grid; } } .wDefine__grid .e-con-inner { display: grid; grid-template-columns: 1fr 1fr; grid-column-gap: 0; margin-left: 0; } .wDefine__grid .e-con-inner .wDefine__gItem:first-child:before { content: ""; width: 2px; height: 100%; background-color: var(--e-global-color-primary); position: absolute; right: 0; top: 0; } .wDefine__grid .e-con-inner .wDefine__gItem p { width: 450px; max-width: 100%; margin-left: auto; margin-right: auto; } .oxoDemand__grid > .e-con-inner { display: grid; grid-template-columns: repeat( auto-fit, minmax(245px, auto)); } .oxoDemand__fImg { width: 100%; height: 100%; z-index: -1; } .oxoDemand > .e-con-inner > *:not(.oxoDemand__fImg) { position: relative; z-index: 10; } .oxoDemand__fImg img { height: 125%; object-fit: contain; margin-right: -88%; position: relative; margin-top: -50px; } @media (max-width:767px) { .wDefine__grid .e-con-inner { grid-template-columns: 1fr; } } /****__ Career Page __****/ @media (min-width: 768px) { .careerInfo__title .elementor-widget-container { background-image: unset !important; } } @media (max-width: 767px){ .careerInfo .careerInfo__item { max-width: 100%; } } /****__ OmniaBio in the News __****/ .oIconList ul { list-style-type: none; padding: 0; margin: 0; } .oIconList ul li { position: relative; padding-left: 35px; } .oIconList ul li:before { content: "\f45c"; font-family: "Font Awesome 5 Free"; font-weight: 900; font-size: 13px; color: var(--e-global-color-secondary ); margin-right: 18px; position: absolute; left: 0; top: 1px; transform: rotate(45deg); } .oIconList ul li:not(:last-child) { margin-bottom: 20px; } .oEvents__grid > .e-con-inner { display: grid; grid-template-columns: repeat( auto-fit, minmax(313.75px, 1fr)); } /****__ Team Page __****/ .teamGrid .ae-post-collection .ae-post-item { transform: unset; } .teamClick { cursor: pointer; } .teamBox .ue-simple-popup-trigger-wrapper { display: none; } .teamBox__mLink .ue-simple-popup-wrapper { height: auto !important; max-height: 90vh !important; } .teamBox__title .ae-element-post-title { margin-bottom: 0; } .teamDetail__title .ae-element-post-title { margin: 0; } .teamClick .ae_thumb_wrapper { opacity: 1; transition: opacity 0.4s ease; } .teamClick:hover .ae_thumb_wrapper { opacity: 0.8; } .teamBox__mLink .ue-simple-popup-inner { max-width: 100%; } .teamBox__mLink .ue-simple-popup-wrapper { max-width: 100%; } @media (max-width: 640px) { .teamBox__mLink .ue-simple-popup-wrapper { padding: 50px 25px 35px !important; } .teamBox__mLink .ue-simple-popup-close { right: 0 !important; top: 5px !important; } } /****__ Resources __****/ .resBox__tax .ae-term-item { line-height: 1.2; } .resBox__tax.resBox__sArea .ae-custom-tax .ae-term-item:not(:first-child) { /* display: none; */ } .resBox__tax { line-height: 0.5; } .resBox { height: 100%; } .snf ul { padding: 0; margin: 0; display: flex; flex-wrap: wrap; column-gap: 20px; row-gap: 10px; align-items: center; } .snf form > ul:before { content: "Filter by:"; font-weight: 700; } .snf ul li { margin: 0; padding: 0; } .snf ul .search-filter-reset { padding: 10px 30px; background-color: var(--e-global-color-primary ) !important; color: #fff; transition: all 0.4s ease; } .snf ul .search-filter-reset:hover { background-color: #ECA100 !important; } .snf ul li * { font-size: 16px !important; font-family: inherit !important; font-weight: 400 !important; color: #000; } .snf ul li select { height: 40px; padding: 8px 10px; background-color: #fff; border-color: #000; border-radius: 0; } @media (max-width: 767px) { .resGrid .ae-post-item { width: 496px; max-width: 100%; } } @media (max-width: 640px) { .snf ul:before { width: 100%; } } .single-post .ast-container { padding: 0; } .newsDet__cont h1, .newsDet__cont h2, .newsDet__cont h3, .newsDet__cont h4, .newsDet__cont h5, .newsDet__cont h6 { margin-bottom: 5px; margin-top: 25px; } .newsDet__cont a:hover { color: var(--e-global-color-accent ); } .nbcShape { position: absolute; top: -150px; right: -125px; line-height: 1; font-size: 0; } .nbcShape .ae-element-post-category span { width: 200px; height: 200px; background-color: var(--e-global-color-accent ); font-size: 0; border-radius: 100%; line-height: 0; } .nbcShape * { font-size: 0; line-height: 1; } .fNewsBlock, .newsBlock { overflow: hidden; } .nbcShape .ae-element-post-category .ae-category-news { background-color: var(--e-global-color-accent ); } .fNewsBlock__title .ae-element-post-title, .newsBlock__title .ae-element-post-title { margin-bottom: 0 !important; } .fNewsBlock__title a, .newsBlock__title a { text-decoration: unset !important; } .fNewsBlock__cat a, .newsBlock__cat a { text-decoration: unset !important; } .newsBlock { height: 100%; } .snf--news .sf-field-category li { min-width: 99px; text-align: center; padding: 4px 15px; background-color: transparent; position: relative; overflow: hidden; border: 2px solid var(--e-global-color-primary); cursor: pointer; } .snf--news .sf-field-category li label { font-weight: bold !important; margin: 0; padding: 0; line-height: 1; color: var(--e-global-color-primary); } .snf--news .sf-field-category li:hover, .snf--news .sf-field-category li.sf-option-active { background-color: var(--e-global-color-primary); } .snf--news .sf-field-category li .sf-input-radio { position: absolute; width: 100%; height: 100%; top: 0; left: 0; z-index: 0; opacity: 0; cursor: pointer; } .snf--news .sf-field-category li { transition: all 0.4s ease; } .snf--news .sf-field-category li.sf-item-6 { background: transparent; border-color: #393F79; } .snf--news .sf-field-category li.sf-item-6 label { color: #393F79; } .snf--news .sf-field-category li.sf-item-6:hover, .snf--news .sf-field-category li.sf-item-6.sf-option-active { background: #393F79; } .snf--news .sf-field-category li.sf-item-1 { background: transparent; border-color: var(--e-global-color-secondary); } .snf--news .sf-field-category li.sf-item-1 label { color: var(--e-global-color-secondary); } .snf--news .sf-field-category li.sf-item-1:hover, .snf--news .sf-field-category li.sf-item-1.sf-option-active { background: var(--e-global-color-secondary); } .snf--news .sf-field-category li.sf-item-7 { background: transparent; border-color: var(--e-global-color-d969f71); } .snf--news .sf-field-category li.sf-item-7 label { color: var(--e-global-color-d969f71); } .snf--news .sf-field-category li.sf-item-7:hover, .snf--news .sf-field-category li.sf-item-7.sf-option-active { background: var(--e-global-color-d969f71); } .snf--news .sf-field-category li:hover label, .snf--news .sf-field-category li.sf-option-active label { color: #fff; } .newsBlock__cat .ae-category-news, .fNewsBlock__cat .ae-category-news{ color: #393F79 !important; } .newsBlock__cat .ae-category-press-releases, .fNewsBlock__cat .ae-category-press-releases { color: var(--e-global-color-secondary) !important; } .newsBlock__cat .ae-category-recent-highlights, .fNewsBlock__cat .ae-category-recent-highlights{ color: var(--e-global-color-d969f71) !important; } .newsDet__cat .ae-category-news { border-color: #393F79 !important; color: #393F79 !important; } .newsDet__cat .ae-category-press-releases { border-color: var(--e-global-color-secondary) !important; color: var(--e-global-color-secondary) !important; } .newsDet__cat .ae-category-recent-highlights { border-color: var(--e-global-color-d969f71) !important; color: var(--e-global-color-d969f71) !important; } .nbcShape .ae-category-news { background-color: #393F79 !important; } .nbcShape .ae-category-press-releases { background-color: var(--e-global-color-secondary) !important; } .nbcShape .ae-category-recent-highlights { background-color: var(--e-global-color-d96f71) !important; } .resGrid .ae-post-collection .search-filter-scroll-loading, .newsPosts__grid .ae-post-collection .search-filter-scroll-loading { animation: unset; border: unset; margin: 0; padding: 0; height: auto; width: auto; display: flex; justify-content: center; grid-column: 1 / -1; } .resGrid .ae-post-collection .search-filter-scroll-loading:before, .newsPosts__grid .ae-post-collection .search-filter-scroll-loading:before{ content: ""; display: inline-block; margin: 0; height: 50px; width: 50px; animation: search-filter-loader-rotate .7s infinite linear; border: 8px solid rgba(0,0,0,.15); border-right-color: rgba(0,0,0,.6); border-radius: 50%; } @media (max-width: 767px) { .oeodSec__fImg { top: unset !important; bottom: 0; } } /****__ Hubspot Form __****/ .hsForm fieldset { max-width: 100% !important; margin-bottom: 20px !important; } .hsForm .form-columns-2 { display: grid !important; grid-template-columns: 1fr 1fr; grid-column-gap: 20px; grid-row-gap: 20px; } .hsForm .form-columns-2 .hs-form-field { width: unset !important; float: unset !important; } .hsForm .hs-form-field { margin-bottom: 20px; } .hsForm fieldset .hs-form-field { margin-bottom: 0; } .hsForm .hs-form-field .input { margin: 5px 0 0 !important; } .hsForm .hs-form-field .input input { height: 55px; } .hsForm .hs-form-field .input .hs-input:not([type="radio"]):not([type="checkbox"]) { width: 100% !important; padding: 10px; background: #fff; border: 1px solid #bababa; } .hsForm .hs-form-field label:not(.hs-error-msg) { font-weight: 700; font-size: 18px; } .hsForm .hs-form-field .hs-field-desc { font-size: 15px; line-height: 15px; margin: 0; padding: 0; color: #343434; } .hsForm .hs-error-msgs { list-style-type: none !important; padding: 0; margin: 0; font-size: 14px; color: red; } .hsForm .hs-form-field textarea { width: 100% !important; background: #fff; } .hsForm .hs-richtext { font-size: 18px; } .hsForm .legal-consent-container .hs-form-field .input { margin: 0 !important; } .hsForm .legal-consent-container .hs-form-field .input .inputs-list, .hsForm .hs-fieldtype-radio .inputs-list { list-style-type: none; padding: 0; } .hsForm .hs-fieldtype-booleancheckbox input.hs-input, .hsForm .hs-fieldtype-radio input.hs-input { width: unset !important; padding: unset !important; height: unset !important; margin-top: 5px; margin-right: 12px; } .hsForm .hs-fieldtype-radio .inputs-list label { font-weight: 500 !important; font-size: 15px !important; } .hsForm .hs-input { font-size: 15px; } .hsForm .hs_submit { margin-top: 45px; } .hsForm .hs_submit .hs-button { transition: all 0.4s ease; } .hsForm .hs-input { border-style: solid !important; } .hsForm .hs-input:focus { border-color: var(--e-global-color-primary) !important; } .hsForm .hs_error_rollup { margin-top: 30px; } @media (max-width: 767px) { .hsForm .form-columns-2 { grid-template-columns: 1fr; } } .cky-notice-btn-wrapper .cky-btn { font-size: 14px !important; line-height: 16px; padding: 10px 22px; } /*** Events item ***/ .oEvents__item{ max-height:360px; } @media (max-width:768px){ .oEvents__item{ max-height:400px; } } /*** Media Inquiries ***/ .media-inquiries a{ color:#fff; } .mediaInq{ border:2px solid #164790; border-radius:5px; padding:15px; max-width:380px; } /* fix for teams box */ .elementor-2018 .elementor-element.elementor-element-4011872 { --display: flex; --gap: 0px 0px; --background-transition: 0.3s; --padding-block-start: 0px; --padding-block-end: 0px; --padding-inline-start: 0px; --padding-inline-end: 0px; } .elementor-2018 .elementor-element.elementor-element-572da0d { --display: flex; --gap: 0px 0px; --background-transition: 0.3s; --padding-block-start: 0px; --padding-block-end: 0px; --padding-inline-start: 0px; --padding-inline-end: 0px; } .elementor-2018 .elementor-element.elementor-element-bc9ae7d { --display: flex; --gap: 0px 0px; --background-transition: 0.3s; --padding-block-start: 0px; --padding-block-end: 0px; --padding-inline-start: 0px; --padding-inline-end: 0px; } .elementor-2018 .elementor-element.elementor-element-51bed3d { text-align: center; } .elementor-2018 .elementor-element.elementor-element-6e6d479 { --display: flex; --gap: 0px 0px; --background-transition: 0.3s; --padding-block-start: 0px; --padding-block-end: 0px; --padding-inline-start: 0px; --padding-inline-end: 0px; } .elementor-2018 .elementor-element.elementor-element-d9f69ab .ae-element-post-title { text-align: center; font-family: "Archivo", Sans-serif; font-size: 25px; font-weight: 700; line-height: 1.1em; } .elementor-2018 .elementor-element.elementor-element-d9f69ab > .elementor-widget-container { margin: 20px 0px 0px 0px; padding: 0px 0px 0px 0px; } .elementor-2018 .elementor-element.elementor-element-0e94954.ae-acf-field-type-image { text-align: center; } .elementor-2018 .elementor-element.elementor-element-0e94954 .ae-acf-wrapper { text-align: center; } .elementor-2018 .elementor-element.elementor-element-0e94954 .ae-acf-content-wrapper { display: inline-block; } .elementor-2018 .elementor-element.elementor-element-0e94954.ae-align-justify .ae-acf-content-wrapper { width: 100%; text-align: center; } .elementor-2018 .elementor-element.elementor-element-0e94954 .ae-acf-content-wrapper, .elementor-2018 .elementor-element.elementor-element-0e94954 .ae-acf-content-wrapper a, .elementor-2018 .elementor-element.elementor-element-0e94954 span { font-family: "Roboto", Sans-serif; font-size: 18px; font-weight: 400; } .elementor-2018 .elementor-element.elementor-element-0e94954 .ae-acf-content-wrapper, .elementor-2018 .elementor-element.elementor-element-0e94954 .ae-acf-content-wrapper a { color: var( --e-global-color-secondary ); } .elementor-2018 .elementor-element.elementor-element-0e94954 span { color: var( --e-global-color-secondary ); } .elementor-2018 .elementor-element.elementor-element-5b91a93 .ue-simple-popup-overlay { align-items: center; justify-content: center; background-color: rgba(0, 0, 0, 0.50); padding: 20px 20px 20px 20px; } .elementor-2018 .elementor-element.elementor-element-5b91a93 .ue-simple-popup-trigger-wrapper { text-align: center; } .elementor-2018 .elementor-element.elementor-element-5b91a93 .ue-simple-popup-trigger { padding: 5px 5px 5px 5px; border-radius: 5px 5px 5px 5px; font-family: "Roboto", Sans-serif; font-weight: 400; text-decoration: none; background-color: #3e3e3e; color: #ffffff; } .elementor-2018 .elementor-element.elementor-element-5b91a93 .ue-simple-popup-trigger svg { fill: #ffffff; } .elementor-2018 .elementor-element.elementor-element-5b91a93 .ue-simple-popup-btn { flex-direction: row; gap: 0px; } .elementor-2018 .elementor-element.elementor-element-5b91a93 .ue-simple-popup-wrapper { width: 1120px; height: 90vh; padding: 70px 60px 60px 60px; background-color: #ffffff; } .resBox__btn a:link { text-decoration:none; } .elementor-2018 .elementor-element.elementor-element-5b91a93 .ue-simple-popup-close { font-size: 20px; color: #000000; width: 30px; height: 30px; border-radius: 100px 100px 100px 100px; } .elementor-2018 .elementor-element.elementor-element-5b91a93 .ue-simple-popup-close svg { min-width: 20px; fill: #000000; } .white-link a{ color:#ffffff; } /* Blog */ .single-omniabio-blog.ast-page-builder-template .site-main > article { padding-top: 0; padding-left: 0; padding-right: 0; } a.meta-category{ color: #000; text-transform: uppercase; text-decoration: none !important; } .meta-category{ color: #000; text-transform: uppercase; text-decoration: none !important; } h2.blog-post-title { color:#174791; } .meta-author{ color: #0E6F79; } span.meta-author, a { text-decoration: none !important; color:#000; } .meta-date { color: #174791; } .postid-5344 .entry-meta { display:none; } .snf-blog ul li select { height: 40px; padding: 0.3rem 2rem; background-color: #174791; border-color: #fff; border-radius: 10px; text-align:center } .snf-blog ul li * { font-size: 1.1rem!important; font-family: inherit !important; font-weight: 500 !important; color: #fff; -webkit-appearance: none; -moz-appearance: none; appearance: none; } .snf-blog ul .search-filter-reset { padding: 10px 30px; background-color: var(--e-global-color-primary ) !important; color: #fff; transition: all 0.4s ease; border-radius:10px; text-transform:none; } .elementor-kit-15 input[type="submit"]:hover { color: #fff; } .snf-blog ul { padding: 0; margin: 0; display: flex; flex-wrap: wrap; column-gap: 20px; row-gap: 10px; align-items: center; } @media (max-width:768px) { .snf-blog ul { margin:0 0 0 10px; } } // Resource tempate .resource-header { display: flex; align-items: center; margin-left: 0; padding-left: 0!important; } .resource-header .entry-title { margin: 0; } .resource-header .wp-block-button { margin-left: 2rem; } .ast-container .resource-header { padding-left:0; margin-top:2rem; margin-bottom:2rem; } /* Post single template */ [id^="poster-cat-id"].ae-custom-tax { font-size: 18px; font-weight: bold; padding: 10px; background-color: #f5f5f5; border-radius: 5px; } .techposter-img { max-width:550px!important; } [id^="poster-cat-id"].ae-custom-tax .ae-term-item { text-transform: uppercase; display: inline-block; margin-right: 10px; padding: 5px 10px; background-color: #e0e0e0; border-radius: 3px; } /* Poster single template */ [id^="poster-cat-id"].ae-custom-tax, #poster-cat-id .ae-term-item { font-size: 18px; font-weight: bold; text-transform: uppercase; } #poster-cat-id .ae-term-item:not(:first-child)::before { content: " | "; margin-right: 5px; } .post-5339 .entry-meta { display: none; } /* headers */ .single-omniabio-blog p a { color:#108bc8 !important; text-decoration:underline !important; } .single-omniabio-blog .ast-footer-copyright a { color:#fff!important; text-decoration:none!important; } .single-omniabio-blog h1 { color:#174791!important; font-size:3rem!important; } .single-omniabio-blog h2 { color: #209f90!important; font-size:2rem!important; } .single-omniabio-blog h3 { color:#2C2D2C !important; font-size:2.5rem!important; } .single-omniabio-blog h3 a { color:#0051A8; font-size:2.5rem!important; } .single-omniabio-blog h4 { color:#2C2D2C !important; font-size:2.2rem!important; } .single-omniabio-blog h4 a { color:#0051A8; font-size:2.2rem!important; } .single-omniabio-blog h5 { color: #209f90!important; font-size:2rem!important; } .single-omniabio-blog h5 a{ color: #209f90!important; font-size:2rem!important; } .single-omniabio-blog h6 { color: #209f90!important; font-size:1.7rem!important; } .single-omniabio-blog h6 a{ color: #209f90!important; font-size:1.7rem!important; } .yellow-button { background-color:#FEAD00; color:#2C2D2C; } .green-button { color:#fff; background-color:1b8377; } //Featured Blog .featured-omniabio-blog { width: 100%; } .featured-image-cover{ padding-top:10px!important; } .featured-omniabio-blog .featured-image-cover { background-size: cover; background-position: center; background-repeat: no-repeat; width: 100%; } .featured-omniabio-blog .post-content { padding: 20px 0px; } .featured-omniabio-blog .blog-category { color: var(--e-global-color-text ); background-color: #FFFFFF; font-family: "Roboto", Sans-serif; font-size: 1rem; font-weight: 400; text-transform: uppercase; padding: 3px 5px 3px 0px; border-radius: 3px 3px 3px 3px; } .featured-omniabio-blog h3 { font-size: 24px; margin-bottom: 10px; } .featured-omniabio-blog .published-date { color: var(--e-global-color-text ); gap: 0px; width: auto; font-size:1rem; } h2.featured-title a{ color:#174791; font-size:3rem; font-weight:400; } .featured-omniabio-blog .excerpt { color: var(--e-global-color-text ); font-family: "Roboto", Sans-serif; font-weight: 400; margin-top: 10px; } .resources-title h1 { color:#174791; font-size:3rem; } /* Salesforce forms */ div.form-wrapper { border: 0px solid #CCC; padding: 10px; } .e-con-inner.has-form { display: flex !important; flex-wrap: wrap !important; } .e-con-inner.has-form > .main-content-column { width: 66% !important; flex: 0 0 66% !important; max-width: 66% !important; transition: all 0.3s ease; } .e-con-inner.has-form > .form-content-column { width: 33% !important; flex: 0 0 33% !important; max-width: 33% !important; display: block !important; transition: all 0.3s ease; } .e-con-inner.no-form > .main-content-column { width: 100% !important; flex: 0 0 100% !important; max-width: 100% !important; transition: all 0.3s ease; } .e-con-inner.no-form > .form-content-column { display: none !important; } .download-field.ae-visibility-hidden { display: none !important; } @media (max-width: 767px) { .e-con-inner.has-form > .main-content-column, .e-con-inner.has-form > .form-content-column, .e-con-inner.no-form > .main-content-column { width: 100% !important; flex: 0 0 100% !important; max-width: 100% !important; } } /* Relationship content */ .relationship-content-grid { display: grid; grid-template-columns: repeat(auto-fill, minmax(300px, 1fr)); gap: 20px; } .relationship-item { border: 0px solid #e0e0e0; border-radius: 8px; overflow: hidden; } .relationship-item-image img { width: 100%; height: auto; display: block; } .relationship-item-content { padding: 15px; } .relationship-item-title { font-size: 1rem; margin: 0 0 10px; } .relationship-item-title a { color: #000 !important; text-decoration: none; } .relationship-item-date { font-size: 1rem; color: #000; margin: 0 0 10px; } .relationship-item-terms { font-size: 1rem; margin: 0; text-transform:uppercase; } p.relationship-item-terms a { color: #000!important; text-decoration: none !important; } /* Download content type */ .resource-dynamic-title h2{ color:#174791!important; } /* featured date and title */ .published-date { font-weight:bold; } h2.featured-title{ font-weight:400; } /* LinkedIn Share */ .linkedin-button { display: inline-flex; align-items: center; justify-content: center; width: 40px; height: 40px; background-color: #174791; color: white; border-radius: 50%; text-decoration: none; transition: background-color 0.3s ease; } .linkedin-button a { color:#fff!important; } .linkedin-button:hover { background-color: #174791 /* Darker blue on hover */ color: #fff; } .linkedin-button i { font-size: 20px; color:#fff; } /* cftIframe */ #cgtIframe { width: 100%; height: 1950px; border: none; overflow: hidden; } @media screen and (max-width: 1120px) { #cgtIframe { height: 2000px; } } @media screen and (max-width: 991px) { #cgtIframe { height: 2100px; } } @media screen and (max-width: 768px) { #cgtIframe { height:2000px; } } @media screen and (max-width: 500px) { #cgtIframe { height:2200px; } } /* Custom Buttons */ .blue-btn { color:#fff ; font-family: "Roboto", Sans-serif; font-size: 1rem; font-weight: 500; line-height: 16px; background: #004896; padding: 12px 15px 12px 15px; border-radius: 10px 10px 10px 10px; display:inline-block; } .single-omniabio-blog p a.blue-btn { color:#fff !important; text-decoration:none !important; } .purple-btn { color:#fff; font-family: "Roboto", Sans-serif; font-size: 1rem; font-weight: 500; line-height: 16px; background: #3D4E98; padding: 12px 15px 12px 15px; border-radius: 10px 10px 10px 10px;display: inline-block; } .single-omniabio-blog p a.purple-btn { color:#fff !important; text-decoration:none !important; } .green-btn { color:#fff; font-family: "Roboto", Sans-serif; font-size: 1rem; font-weight: 500; line-height: 16px; background: #1B8377; padding: 12px 15px 12px 15px; border-radius: 10px 10px 10px 10px; display:inline-block; } .single-omniabio-blog p a.green-btn { color:#fff !important; text-decoration:none !important; } .yellow-btn { color:#2C2D2C !important; font-family: "Roboto", Sans-serif; font-size: 1rem; font-weight: 500; line-height: 16px; background: #FEAD00; padding: 12px 15px 12px 15px; border-radius: 10px 10px 10px 10px; display:inline-block; } .single-omniabio-blog p a.yellow-btn { color:#2C2D2C !important; text-decoration:none !important; } .related-post-image img{ aspect-ratio: 16/9; /* Adjust ratio as needed */ width: 100%; height: auto; } /* iframe contact */ #iframe-contact { width: 100%; height: 1800px; } @media (max-width: 1200px) { #iframe-contact { height: 1900px; } } @media (max-width: 768px) { #iframe-contact { height: 2250px; } } /* Foot Menu Top Level Links */ #menu-footer-menu li a { font-size: 14px; pointer-events: auto; } </style> </head> <body itemtype='https://schema.org/Blog' itemscope='itemscope' class="post-template-default single single-post postid-8168 single-format-standard wp-custom-logo wp-embed-responsive ast-desktop ast-plain-container ast-no-sidebar astra-4.8.3 group-blog ast-blog-single-style-1 ast-single-post ast-inherit-site-logo-transparent ast-hfb-header ast-normal-title-enabled elementor-default elementor-kit-15 elementor-page elementor-page-8168"> <a class="skip-link screen-reader-text" href="#content" title="Skip to content"> Skip to content</a> <div class="hfeed site" id="page"> <header class="site-header header-main-layout-1 ast-primary-menu-enabled ast-hide-custom-menu-mobile ast-builder-menu-toggle-link 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</ul></div></nav></div></div> </div> </div> </div> </header> <div id="content" class="site-content"> <div class="ast-container"> <div id="primary" class="content-area primary"> <main id="main" class="site-main" role="main"> <article itemtype="http://schema.org/CreativeWork" itemscope="itemscope" id="post-8168" class="post-8168 post type-post status-publish format-standard hentry category-press-releases tag-featured ast-article-single"> <div class="ae_data elementor elementor-2274" data-aetid="2274"> <div data-elementor-type="wp-post" data-elementor-id="2274" class="elementor elementor-2274"> <div class="has_ae_slider elementor-element elementor-element-78c5dc2 newsDet e-flex e-con-boxed ae-bg-gallery-type-default e-con e-parent" data-id="78c5dc2" data-element_type="container"> <div class="e-con-inner"> <div class="has_ae_slider elementor-element elementor-element-afb0786 e-con-full newsDet__global e-flex ae-bg-gallery-type-default e-con e-parent" data-id="afb0786" 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ae-pm-layout-mobile-"> <div class="ae-post-meta-item-wrapper ae-post-cat"> <span class="ae-element-post-category-label"> </span> <span class="ae-element-post-category"> <span class="ae-category-press-releases">Press Releases</span> </span> </div> </div> </div> </div> <div class="elementor-element elementor-element-ee65695 elementor-widget elementor-widget-ae-post-title" data-id="ee65695" data-element_type="widget" data-widget_type="ae-post-title.default"> <div class="elementor-widget-container"> <h1 itemprop="name" class="ae-element-post-title">LineaBio submits Drug Master File for Linea 1 GMP iPSC line to U.S. Food and Drug Administration</h1> </div> </div> <div class="elementor-element elementor-element-a34f35e newsDet__date elementor-widget elementor-widget-ae-post-meta" data-id="a34f35e" data-element_type="widget" data-settings="{"layout_mode":"horizontal"}" data-widget_type="ae-post-meta.default"> <div class="elementor-widget-container"> <div class="ae-post-meta-list-wrapper ae-pm-layout-horizontal ae-pm-layout-tablet- ae-pm-layout-mobile-"> <div class="ae-post-meta-item-wrapper ae-post-date-11-20-2024"> <span class="ae-element-post-date-label"> </span> <span class="ae-element-post-date" title="2:42 PM" rel="date"> <span class="ae-post-date-11-20-2024">November 20, 2024</span> </span> </div> </div> </div> </div> </div> <div class="has_ae_slider elementor-element elementor-element-92cfeb9 e-con-full newsDet__cont e-flex ae-bg-gallery-type-default e-con e-parent" data-id="92cfeb9" data-element_type="container"> <div class="elementor-element elementor-element-f8f2aff elementor-widget elementor-widget-spacer" data-id="f8f2aff" data-element_type="widget" data-widget_type="spacer.default"> <div class="elementor-widget-container"> <div class="elementor-spacer"> <div class="elementor-spacer-inner"></div> </div> </div> </div> <div class="elementor-element elementor-element-d5b070e elementor-widget elementor-widget-ae-post-content" data-id="d5b070e" data-element_type="widget" data-widget_type="ae-post-content.default"> <div class="elementor-widget-container"> <div class="ae-element-post-content"> <style>.elementor-8168 .elementor-element.elementor-element-f913d1c{--display:flex;--background-transition:0.3s;}.elementor-widget-text-editor{color:var( --e-global-color-text );font-family:var( --e-global-typography-text-font-family ), Sans-serif;font-weight:var( --e-global-typography-text-font-weight );}.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:var( --e-global-color-primary );}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap, .elementor-widget-text-editor.elementor-drop-cap-view-default .elementor-drop-cap{color:var( --e-global-color-primary );border-color:var( --e-global-color-primary );}</style> <div data-elementor-type="wp-post" data-elementor-id="8168" class="elementor elementor-8168"> <div class="has_ae_slider elementor-element elementor-element-f913d1c e-flex e-con-boxed ae-bg-gallery-type-default e-con e-parent" data-id="f913d1c" data-element_type="container"> <div class="e-con-inner"> <div class="elementor-element elementor-element-c0ab7e2 elementor-widget elementor-widget-text-editor" data-id="c0ab7e2" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong>November 20, 2024</strong> (Toronto, Ontario) – LineaBio, a cell line company, today announced it has submitted a Type II Drug Master File (DMF) to the U.S. Food and Drug Administration (FDA) for its flagship unmodified, off-the-shelf, Good Manufacturing Practices (GMP)-compliant induced pluripotent stem cell (iPSC) line, Linea 1.</p><p>LineaBio was launched in 2023 by parent companies <a href="http://www.ccrm.ca/">CCRM</a>, a global leader in iPSC capabilities and platform development, and <a href="http://www.omniabio.com/">OmniaBio</a>, a technology-focused cell and gene therapy clinical and commercial contract development and manufacturing organization. The company’s off-the-shelf iPSC lines will enable cell therapy developers by accelerating time to GMP by 12 months and reducing cell line development costs by up to 60 per cent.</p><p>The DMF provides a comprehensive chemistry, manufacturing and controls (CMC) data package for Linea 1. More broadly, the DMF includes information related to the manufacturers, manufacturing process, control of materials, specifications and analytical procedures used in the manufacturing of Linea 1. Any developer that executes a commercial license with LineaBio to conduct clinical research using the Linea 1 line will be provided a Letter of Authorization (LOA) at the time of its Investigational New Drug (IND) submission to the FDA. The LOA will allow the FDA to refer to the contents of the DMF during review of an IND submission.</p><p>“Ultimately, LineaBio’s mission is to enable the cell and gene therapy industry. Drug master files are an essential component of high-quality, off-the-shelf iPSC lines, as they standardize the CMC data package,” says Mark Curtis, CEO of LineaBio. “LineaBio is committed to ensuring all current and prospective off-the-shelf Linea iPSC lines are covered by a DMF, so drug developers can readily incorporate a comprehensive CMC data package into their regulatory submissions by reference.”</p><p>LineaBio engaged <a href="https://www.darkhorseconsultinggroup.com/">Dark Horse Consulting</a> (DHC) to author the DMF. DHC’s team of technical writers has considerable experience in preparing master files for submission to the FDA and deep technical expertise in the field of iPSCs.</p><p>LineaBio is actively working on characterizing the Linea 1 GMP iPSC line. The DMF for Linea 1 will be updated as necessary to support client needs and programs.</p><p><strong> </strong></p><p><strong>About LineaBio </strong></p><p>LineaBio’s mission is to enable the cell and gene therapy industry by providing access to high-quality, off-the-shelf iPSC lines manufactured under GMP that streamline drug product manufacturing. By allowing therapeutic developers to cut costs and accelerate timelines for GMP reprogramming, LineaBio strives to achieve its vision of making cell therapy universally accessible and affordable. Founded in 2023 by parent companies <a href="http://www.ccrm.ca/">CCRM</a> and <a href="http://www.omniabio.com/">OmniaBio</a>, LineaBio draws on a team of iPSC experts that have been developing an iPSC platform since 2012. 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