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href="https://ca.wikipedia.org/wiki/Esclerosi_(medicina)" title="Esclerosi (medicina) – Catalan" lang="ca" hreflang="ca" data-title="Esclerosi (medicina)" data-language-autonym="Català" data-language-local-name="Catalan" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Sklerose" title="Sklerose – German" lang="de" hreflang="de" data-title="Sklerose" data-language-autonym="Deutsch" data-language-local-name="German" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Esclerosis" title="Esclerosis – Spanish" lang="es" hreflang="es" data-title="Esclerosis" data-language-autonym="Español" data-language-local-name="Spanish" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-eu mw-list-item"><a href="https://eu.wikipedia.org/wiki/Esklerosi" title="Esklerosi – Basque" lang="eu" hreflang="eu" data-title="Esklerosi" data-language-autonym="Euskara" data-language-local-name="Basque" class="interlanguage-link-target"><span>Euskara</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D8%B3%D8%AE%D8%AA%D8%A7%DA%A9" title="سختاک – Persian" lang="fa" hreflang="fa" data-title="سختاک" data-language-autonym="فارسی" data-language-local-name="Persian" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Scl%C3%A9rose" title="Sclérose – French" lang="fr" hreflang="fr" data-title="Sclérose" data-language-autonym="Français" data-language-local-name="French" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-hy mw-list-item"><a href="https://hy.wikipedia.org/wiki/%D4%BF%D5%A1%D6%80%D5%AE%D6%80%D5%A1%D5%AD%D5%BF" title="Կարծրախտ – Armenian" lang="hy" hreflang="hy" data-title="Կարծրախտ" data-language-autonym="Հայերեն" data-language-local-name="Armenian" class="interlanguage-link-target"><span>Հայերեն</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Sclerosi" title="Sclerosi – Italian" lang="it" hreflang="it" data-title="Sclerosi" data-language-autonym="Italiano" data-language-local-name="Italian" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/%D7%98%D7%A8%D7%A9%D7%AA" title="טרשת – Hebrew" lang="he" hreflang="he" data-title="טרשת" data-language-autonym="עברית" data-language-local-name="Hebrew" class="interlanguage-link-target"><span>עברית</span></a></li><li class="interlanguage-link interwiki-kk mw-list-item"><a href="https://kk.wikipedia.org/wiki/%D0%A1%D0%BA%D0%BB%D0%B5%D1%80%D0%BE%D0%B7" title="Склероз – Kazakh" lang="kk" hreflang="kk" data-title="Склероз" data-language-autonym="Қазақша" data-language-local-name="Kazakh" class="interlanguage-link-target"><span>Қазақша</span></a></li><li class="interlanguage-link interwiki-ky mw-list-item"><a href="https://ky.wikipedia.org/wiki/%D0%A1%D0%BA%D0%BB%D0%B5%D1%80%D0%BE%D0%B7" title="Склероз – Kyrgyz" lang="ky" hreflang="ky" data-title="Склероз" data-language-autonym="Кыргызча" data-language-local-name="Kyrgyz" class="interlanguage-link-target"><span>Кыргызча</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Sclerose" title="Sclerose – Dutch" lang="nl" hreflang="nl" data-title="Sclerose" data-language-autonym="Nederlands" data-language-local-name="Dutch" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-nn mw-list-item"><a href="https://nn.wikipedia.org/wiki/Sklerose" title="Sklerose – Norwegian Nynorsk" lang="nn" hreflang="nn" data-title="Sklerose" data-language-autonym="Norsk nynorsk" data-language-local-name="Norwegian Nynorsk" class="interlanguage-link-target"><span>Norsk nynorsk</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%A1%D0%BA%D0%BB%D0%B5%D1%80%D0%BE%D0%B7" title="Склероз – Russian" lang="ru" hreflang="ru" data-title="Склероз" data-language-autonym="Русский" data-language-local-name="Russian" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/Skleros_(medicin)" title="Skleros (medicin) – Swedish" lang="sv" hreflang="sv" data-title="Skleros (medicin)" data-language-autonym="Svenska" data-language-local-name="Swedish" class="interlanguage-link-target"><span>Svenska</span></a></li><li class="interlanguage-link interwiki-ta mw-list-item"><a href="https://ta.wikipedia.org/wiki/%E0%AE%A4%E0%AE%BF%E0%AE%9A%E0%AF%81_%E0%AE%A4%E0%AE%9F%E0%AE%BF%E0%AE%AE%E0%AE%A9%E0%AE%BE%E0%AE%A4%E0%AE%B2%E0%AF%8D_(%E0%AE%AE%E0%AE%B0%E0%AF%81%E0%AE%A4%E0%AF%8D%E0%AE%A4%E0%AF%81%E0%AE%B5%E0%AE%AE%E0%AF%8D)" title="திசு தடிமனாதல் (மருத்துவம்) – Tamil" lang="ta" hreflang="ta" data-title="திசு தடிமனாதல் (மருத்துவம்)" data-language-autonym="தமிழ்" data-language-local-name="Tamil" class="interlanguage-link-target"><span>தமிழ்</span></a></li><li class="interlanguage-link interwiki-tt mw-list-item"><a href="https://tt.wikipedia.org/wiki/%D0%A1%D0%BA%D0%BB%D0%B5%D1%80%D0%BE%D0%B7" title="Склероз – Tatar" lang="tt" hreflang="tt" data-title="Склероз" data-language-autonym="Татарча / tatarça" data-language-local-name="Tatar" class="interlanguage-link-target"><span>Татарча / tatarça</span></a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/Skleroz" title="Skleroz – Turkish" lang="tr" 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i{font-style:normal}.mw-parser-output .hatnote+link+.hatnote{margin-top:-0.5em}@media print{body.ns-0 .mw-parser-output .hatnote{display:none!important}}</style><div role="note" class="hatnote navigation-not-searchable">For other uses, see <a href="/wiki/Sclerosis_(disambiguation)" class="mw-redirect mw-disambig" title="Sclerosis (disambiguation)">Sclerosis (disambiguation)</a>.</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Not to be confused with <a href="/wiki/Scoliosis" title="Scoliosis">Scoliosis</a>.</div> <div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Medical condition</div><style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox ib-medical-condition"><tbody><tr><th colspan="2" class="infobox-above" style="background:#ccc">Sclerosis</th></tr><tr><th scope="row" class="infobox-label">Other names</th><td class="infobox-data">Sclerosus</td></tr><tr style="background-color: #f8f9fa;"><td colspan="2" class="infobox-full-data"><span class="mw-default-size" typeof="mw:File/Frameless"><a href="/wiki/File:Lichen_sclerosus_-_very_high_mag.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/a/ab/Lichen_sclerosus_-_very_high_mag.jpg/220px-Lichen_sclerosus_-_very_high_mag.jpg" decoding="async" width="220" height="147" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/ab/Lichen_sclerosus_-_very_high_mag.jpg/330px-Lichen_sclerosus_-_very_high_mag.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/ab/Lichen_sclerosus_-_very_high_mag.jpg/440px-Lichen_sclerosus_-_very_high_mag.jpg 2x" data-file-width="4272" data-file-height="2848" /></a></span></td></tr><tr><td colspan="2" class="infobox-full-data"><a href="/wiki/Micrograph" title="Micrograph">Micrograph</a> of subepithelial sclerosus (middle third of image) in a case of <a href="/wiki/Lichen_sclerosus" title="Lichen sclerosus">lichen sclerosus</a>. <a href="/wiki/H%26E_stain" title="H&E stain">H&E stain</a>.</td></tr></tbody></table> <p><b>Sclerosis</b> (from <a href="/wiki/Ancient_Greek_language" class="mw-redirect" title="Ancient Greek language">Ancient Greek</a> <i> </i>σκληρός<i> (sklērós)</i> 'hard') is the stiffening of a <a href="/wiki/Tissue_(biology)" title="Tissue (biology)">tissue</a> or anatomical feature, usually caused by a replacement of the normal <a href="/wiki/Organ_(biology)" title="Organ (biology)">organ</a>-specific tissue with <a href="/wiki/Connective_tissue" title="Connective tissue">connective tissue</a>. The structure may be said to have undergone sclerotic changes or display sclerotic <a href="/wiki/Lesions" class="mw-redirect" title="Lesions">lesions</a>, which refers to the process of sclerosis. </p><p>Common medical conditions whose pathology involves sclerosis include: </p> <ul><li><a href="/wiki/Amyotrophic_lateral_sclerosis" class="mw-redirect" title="Amyotrophic lateral sclerosis">Amyotrophic lateral sclerosis</a>—also known as <a href="/wiki/Lou_Gehrig" title="Lou Gehrig">Lou Gehrig</a>'s disease or motor neurone disease—a progressive, incurable, usually fatal disease of <a href="/wiki/Motor_neurons" class="mw-redirect" title="Motor neurons">motor neurons</a>.</li> <li><a href="/wiki/Atherosclerosis" title="Atherosclerosis">Atherosclerosis</a>, a deposit of fatty materials, such as cholesterol, in the arteries which causes hardening.</li> <li><a href="/wiki/Focal_segmental_glomerulosclerosis" title="Focal segmental glomerulosclerosis">Focal segmental glomerulosclerosis</a> is a disease that attacks the <a href="/wiki/Kidney" title="Kidney">kidney</a>'s filtering system (<a href="/wiki/Glomerulus_(kidney)" title="Glomerulus (kidney)">glomeruli</a>) causing serious scarring and thus a cause of <a href="/wiki/Nephrotic_syndrome" title="Nephrotic syndrome">nephrotic syndrome</a> in children and adolescents,<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> as well as an important cause of kidney failure in adults.</li> <li><a href="/wiki/Hippocampal_sclerosis" title="Hippocampal sclerosis">Hippocampal sclerosis</a>, a brain damage often seen in individuals with temporal lobe epilepsy.</li> <li><a href="/wiki/Lichen_sclerosus" title="Lichen sclerosus">Lichen sclerosus</a>, an inflammatory skin disease that most often affects the vulva and the penis.</li> <li><a href="/wiki/Multiple_sclerosis" title="Multiple sclerosis">Multiple sclerosis</a>, or focal sclerosis,<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> is a central nervous system disease which affects coordination.</li> <li><a href="/wiki/Osteosclerosis" title="Osteosclerosis">Osteosclerosis</a>, a condition where the bone density is significantly increased, resulting in decreased lucency on radiographs.</li> <li><a href="/wiki/Otosclerosis" title="Otosclerosis">Otosclerosis</a>, a disease of the ears.</li> <li><a href="/wiki/Primary_lateral_sclerosis" title="Primary lateral sclerosis">Primary lateral sclerosis</a>, progressive muscle weakness in the voluntary muscles.</li> <li><a href="/wiki/Primary_sclerosing_cholangitis" title="Primary sclerosing cholangitis">Primary sclerosing cholangitis</a>, a hardening of the bile duct by scarring and repeated inflammation.</li> <li><a href="/wiki/Systemic_sclerosis" class="mw-redirect" title="Systemic sclerosis">Systemic sclerosis</a> (progressive systemic <a href="/wiki/Scleroderma" title="Scleroderma">scleroderma</a>), a rare, chronic disease which affects the skin, and in some cases also blood vessels and internal organs.</li> <li><a href="/wiki/Tuberous_sclerosis" title="Tuberous sclerosis">Tuberous sclerosis</a>, a rare genetic disease which affects multiple systems.</li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Sclerosis_(medicine)&action=edit&section=1" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output 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q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited 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.cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20090602184312/http://www.nephcure.org/fsgs-facts.htm">"Welcome To The NephCure Foundation"</a>. Archived from <a rel="nofollow" class="external text" href="http://www.nephcure.org/fsgs-facts.htm">the original</a> on 2009-06-02.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Welcome+To+The+NephCure+Foundation&rft_id=http%3A%2F%2Fwww.nephcure.org%2Ffsgs-facts.htm&rfr_id=info%3Asid%2Fen.wikipedia.org%3ASclerosis+%28medicine%29" class="Z3988"></span></span> </li> <li id="cite_note-2"><span class="mw-cite-backlink"><b><a href="#cite_ref-2">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.medterms.com/script/main/art.asp?articlekey=25814">"Focal sclerosis definition - Medical Dictionary definitions of popular medical terms easily defined on MedTerms"</a>. Medterms.com. 2012-09-20<span class="reference-accessdate">. Retrieved <span class="nowrap">2013-01-12</span></span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Focal+sclerosis+definition+-+Medical+Dictionary+definitions+of+popular+medical+terms+easily+defined+on+MedTerms&rft.pub=Medterms.com&rft.date=2012-09-20&rft_id=http%3A%2F%2Fwww.medterms.com%2Fscript%2Fmain%2Fart.asp%3Farticlekey%3D25814&rfr_id=info%3Asid%2Fen.wikipedia.org%3ASclerosis+%28medicine%29" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Sclerosis_(medicine)&action=edit&section=2" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1236075235">.mw-parser-output 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dt:last-child::after,.mw-parser-output .hlist li li:last-child::after{content:")";font-weight:normal}.mw-parser-output .hlist ol{counter-reset:listitem}.mw-parser-output .hlist ol>li{counter-increment:listitem}.mw-parser-output .hlist ol>li::before{content:" "counter(listitem)"\a0 "}.mw-parser-output .hlist dd ol>li:first-child::before,.mw-parser-output .hlist dt ol>li:first-child::before,.mw-parser-output .hlist li ol>li:first-child::before{content:" ("counter(listitem)"\a0 "}</style></div><div role="navigation" class="navbox" aria-label="Navbox" style="width:100%; margin:0.5em 0 0.5em 0;;padding:3px"><table class="nowraplinks navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background: #EAECF0;color:black;">Classification</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><div style="position:relative; float:right; font-size:0.8em;"><a href="https://www.wikidata.org/wiki/Q140067" class="extiw" title="d:Q140067">D</a></div><div class="hlist" style="text-align:left;"><ul><li><b><a href="/wiki/Medical_Subject_Headings" title="Medical Subject Headings">MeSH</a></b>: <a rel="nofollow" class="external text" href="https://meshb.nlm.nih.gov/record/ui?ui=D012598">D012598</a></li></ul></div></div></td></tr></tbody></table></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Retrieved from "<a dir="ltr" href="https://en.wikipedia.org/w/index.php?title=Sclerosis_(medicine)&oldid=1238112681">https://en.wikipedia.org/w/index.php?title=Sclerosis_(medicine)&oldid=1238112681</a>"</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Help:Category" 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