CINXE.COM
Just a moment...
<!DOCTYPE html><html lang="en-US"><head><title>Just a moment...</title><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta http-equiv="X-UA-Compatible" content="IE=Edge"><meta name="robots" content="noindex,nofollow"><meta name="viewport" content="width=device-width,initial-scale=1"><style>*{box-sizing:border-box;margin:0;padding:0}html{line-height:1.15;-webkit-text-size-adjust:100%;color:#313131;font-family:system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica Neue,Arial,Noto Sans,sans-serif,Apple Color Emoji,Segoe UI Emoji,Segoe UI Symbol,Noto Color Emoji}body{display:flex;flex-direction:column;height:100vh;min-height:100vh}.main-content{margin:8rem auto;max-width:60rem;padding-left:1.5rem}@media (width <= 720px){.main-content{margin-top:4rem}}.h2{font-size:1.5rem;font-weight:500;line-height:2.25rem}@media (width <= 720px){.h2{font-size:1.25rem;line-height:1.5rem}}#challenge-error-text{background-image:url(data:image/svg+xml;base64,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);background-repeat:no-repeat;background-size:contain;padding-left:34px}@media (prefers-color-scheme:dark){body{background-color:#222;color:#d9d9d9}}</style><meta http-equiv="refresh" content="390"></head><body class="no-js"><div class="main-wrapper" role="main"><div class="main-content"><noscript><div class="h2"><span id="challenge-error-text">Enable JavaScript and cookies to continue</span></div></noscript></div></div><script>(function(){window._cf_chl_opt={cvId: '3',cZone: "www.science.org",cType: 'managed',cRay: '8e6ff707ccd7ce31',cH: 'tQCbvW6bEPVwrMDVNZz5k4kIvK4dsgDP3LT8R22hq3E-1732352385-1.2.1.1-Ar_mC8b1TkfgktFvGm5VlXzp5wR7CT9eBFBlY3p8bspjA7nvzS848EKM87T20iX9',cUPMDTk: "\/doi\/10.1126\/science.aad1329?__cf_chl_tk=eSr9TG_AB7tByJYkb9wj1ysSzVxWGc_xinqm6K2BKF8-1732352385-1.0.1.1-L53s3vybxgx1VzUra7TEi9YzAnYVmo4hTfSgzBEbruI",cFPWv: 'g',cITimeS: '1732352385',cTTimeMs: '1000',cMTimeMs: '390000',cTplC: 0,cTplV: 5,cTplB: 'cf',cK: "",fa: "\/doi\/10.1126\/science.aad1329?__cf_chl_f_tk=eSr9TG_AB7tByJYkb9wj1ysSzVxWGc_xinqm6K2BKF8-1732352385-1.0.1.1-L53s3vybxgx1VzUra7TEi9YzAnYVmo4hTfSgzBEbruI",md: "FyUZuVSP28c6tVjdJzNhVuJcbujP_l3Li9nM.seRipw-1732352385-1.2.1.1-9ibSnYVPF6VEZzCSlHtsDJmYVBjFTxeYiZJBymqB14SZiQbP7HW4vo9Sh2WBVTyDbSTNgqvRncz02dBiGVNizzBSIc_8Ky5VcfPHp.4gh_9Qfq.ZGtiOE.iGxrMCUnuBBjj9ZoDsgoX61ff.jA8tGqMogd15zF1JYi3ldfUUGPZrN_DmPOU4OB_njeOajoNV5abM8KPckpshh0wWhMmi7a5tZQzAFCTSM6mSEpmM31JQuV27UF5ppLBMhFQsNLEPkMqgsG9JEfkfPG5ou4oaHCl1I5XeqloP.zYOI9XF1MzfiucEPa6MWbJMzFP.G2zN_O3mH6TsbJMvYM51lXcvs_jtqLjcfHpQ2DBeohtTtIQI_hiTeDEj7xN_freZebMdYiSgN1KDM68xNNO8W9NeIqhRMpwlHkkUgE.8QJBV_xbc1k5.t6jya.DdbcshOQ0J1RZ5aYzVGA8SwCr1K202sXEpOLWrzgTodvkmiH.cI6lJmg1d207eff8__lZbbET.p1CI_7KK06mhiL7baSNHclOfqzdLjT6cya779qvFpYAahb6qkUc67B4z_fuJKpsPYEyGR6dvG6spzxPTGxcacjaqpsHqEsdmrp_RCnEjdKgS.gd8WmGJiNSJU7AqbeQQrWU.DKDVyM9XIOyJkInf9D5ImGlv64SUWObRa0BBkF3CMEM..Bt3ynLXAFbDGrTPpQZiy5_BaHtK0HDFfiBLfnaCouJeXDjIXijr9uQVl3H7CVvjKf8g8WoJ4.SEJPbTY8.fs9MmXUaTWGufDWSSR2YV_d3HwVoSuYd1rnf2DFHUU6GaIcRCwuuJjS8VahHMWC96pqupFmQkzzrlpUvQQ3vZgDDUuEa8nQWakX8hz.dckmorD6hWErWgyQLjXZ_pq4VDsH_ExQ1VdrXArcokLGS_ToFTB9C9OV8BvB7o_x0A9wesIgJ9DfEl6gV_2C6eCRQ6eape8TfbScBQq7VXvS.6XNIxE7ANUaUwNo3FB5W9n0u4nVtrJUlf5xt0S93tJasf03ZXnstYO.jJi1FnUTM6.3sp78zqvVEadYJifzGp_nuXzzRdC0jNrorDSWkToGhs8QzvUm1RFsZgJxZqYiEHzn53TD5YCKInKvGijygKiCCghrmrieMOxIU7nYbK4ZbNXwWCho7JaUX88HEuyVyJHvU.pXEFpLzcbwNXJyzzWr4xXbcj8fJT82Gsbw1JPSZantPoP_boxt8Z38_sHSO2ceMPooJzYoCF11h2GV2Rol2Gzqgzw1i6haxIX06bG6Vbie69dDabguPJ2oxwNTltVTpxjz2y.lMtML2dB7hvZn_5R3ogvVQnYvLDALwI4ePrb77NFS7Wz5FbVPXmnQUk5HE5H1zS.2lG_1wkH6Yw_qaDmNepguFqzmW8gkIEC05Tf0POsXu6TugfTe6phs3_LOs3VwUVfbRT31xi_cXNutCiGmdmhgm2lTtK2yZXg_.sJaAsC_cMnkEdtXSuAKv5Rv7cKanl8W6oz.P78HwHDuWH6wkbP3JVKLKS0L_Td7qOAnkJp_sXWlRm1sqjI1SA8bMCA7aGVTkvlpPhW4_P06.zxek3wCKw5Pv6T7_cOjEntiptPWZNYREqg7NttCAH7GfxxGCB.40kO9IsmVZWWZgCy5WSeKc321RGGPG9Mj_spezzbiT6pyXMr.O0bW8oMbzQBtiJwjnyjni8D955gUEonXlWkuRUJQp6cANgy.PmLCKbHS4XzuiDn6r1jQt1LJXSG1P7eGITSaXQ2IIVWMPzx_J.N5qdF.ua4xiXOmVpWGUz0RNHKZ9fJXECSi_tbgikt6NGtKot0lmD17fuEpaFZEhfpGXahGQKGUqu36dUw2dFJ4.iJOuBT1z0KJIa.jnu0ozu3vmaBeXl9NTHArdNWblNcmnq8gzvh3._nXsce_mk72wVpLs35kgvucmOMxmfLC369KFtetaum5B_MBd5ZPfHGuzxjO0GPdQGXx0fnp0B.lBNSd8KLOnWE5P4lV3GXUimSAwvYbK7rlhMhsD8CqkNYYn1kOgY094yB94JJimNfehX_jpA_Dy3K140StWgtNgcTqkBMcUM3wNuC90sjpNN59PpoztzMezzIhe_7vZPzOvDVBhi4K4gtT4WhJ6VqntFZiJEIIr5RbXSR0667cbPhLjGEbu4.eSu6tjnBpR.8IIZD7BuzmflxlzXnWdJAzSzEr8BH2PiBFke0G9zf42_Yxf54MH0sfrO3qP7slHjIrsfcyhdWXyxS0dgdhWZd_50XttMuPYBhBNATiGxGEykha6TlBhqoo3GmhycJTBoGi4xP6..utcHQeiXLR04lebxiDfofjwTTxV2WQ3WbRvZ4Cw6T0gCDAtuAlR1j9u3CKl6Sc2D5PFMXUO0.YQnDshwWkFu_IlC1aOQytOMenXh5GXaL2L_raoTpzvJ7Deazp6MyKdksLg.McLJDgOIjbTu1Oz3w3dtXXDR68zm.LWh7xrEgTsGTOl_RE3TlFwtLr5BRd_xpSHwDA2KVZtl7oEj01Efs1NBr3l_hMXEmgkIG_L_jJTeWdWmhtiaD433ubmMUuf5UvvCoqYZUStnqeogx798cesQcw3RI7L.D_XKtLqYz3fbJ5O90CRBLhFNqoBgcdTnLLpYphfnhU36q3otpwgh33KTHr_mE7KfjDpvaefBR.K9T9Fs1mdIOQAqqu3ZX9lMrSYpUSzoriBzFOvVF6_8IWwwyQCnTwmqEW2NeDfBWf_.Qozk_CWx4bWLfGPN.jmj9AAOTvO8uqL1mik3ArVdCoGyWc9WKV.dVsNlxM3faJ1r.f91nmI2Lzy3d42JFyz_1cOuytMzD4CGqDWl4Xw.8.XUQqph0CFernA9BxCx9RtOG6zUsoM869q2zlt8NFKMkuwG8DW4e_JPJOW4_w9JGjzPefuEChjwzVltvncilwEQ.puQE1aqya9oBgxeKlAjxZyRf.lGKzaPbfi4ydWbUV38ZbQ",mdrd: "qn9ZX_5PFY1WW7rGwpjV4lFLkKSEiINkSzZhU1gwpj4-1732352385-1.2.1.1-VSDGDotGy1u2Z0kmman0h1A1.uT1ZG0Cql1p1ZP1lgGmqPyeAFfApi4t6JcNN9dpiuNo1Ml5mZpEruVf42Glq9tzlpySPq.URbmYPZLo0mYwM.yzmJ10dyB.lE3nY8WVOfiiKKpJNU7nuqixohasLciY_Yv8VtvJJukfVQDnQWOg_iVmqOck0UOTx5T3FUjjhf2SPiGU5.RUi0v4QqMb4QsM2h9rWDf5J5hFw0V4VExgThbbn93RCaJZlxreln.ON3_DA_rTvu5n2tBDuyvKE4UoT2iqyXhUqozM01gNJKYpJ4K4ROwgKTKRO5ILOeJieL3L0KkkIUas61T1fdEGWGlcv4yzcxiOfxPSvfOmQU6ll.Zh7Unl38eZPyIkgd5CKYX7pXLqwVd_gQuiONCRk7NmzcZMuG7.3T4S5.0S_1CObO0vAW5dFxsZAym__Sgi5rGGvLXzV3UyxeViCBeSsYlafF4gFj9bK8ojo9PBQedtXFF8alLc9TJGsnOjyghfu7i00DOizq0vA0jHygWbpR7MwkcqASkEWAvMt0pvKJ2AsdnmcnD5dXkaJRNh2tp0UUAD8hJekGgt4g.qIn5MUad.cOC.dlFBfZYhKVJfmY16jT43r__bOoxov9ReVqZhYEEa2mH8nVoeL7XMfAjldK0UmLlR4zng4om_HJQf7VhOZ8TSmjXPJYMQGsFDNnerB0xoA3nrLjM.6QL4e2hZonN7p7KzsbDq0teQ1.PS_bDQCwd8hvGMzy_LtKMElD7wevqVLqYrRcip3ADKWFAYkfZFX9QWHazfpkOwdfSMCrwZQFB1_jhQ7gtLAdkG2_zwUBJEuJDahLRkTGrh.y7y6T.WMreMwKu8YwlC6HuBKpUsKmT_.KK8X.2LRgy1LobVw8YNq8gNNa2usCm..AUnFbOGkVueqoondJyFZGBI2a7bSqo1fYhwGDKw6cunC8j3AbUED8.nBflwRR6uPWX9BdyqldmLKIpE73zrL.OahgJGZHGwRHPQti5USsj9XMYpVOCuwIq0xbTwmXlEQ69XvJDDZMOKu2PU_ApeA5rrA69abst6f4pFFGzNUcYr_jBTXsG0n_Y2U5Ax.1Tv7J.GD5n.oS7M79Uep0KVQDsLcnSrbziCN2HJr73PIsVkbsAt7zHLkiQ4GgRII1IoS4Avn284cpODRcGl7DSNrofwWOU2yEBefdkObgtHCCieGHl1_DsMm3vn0oMq.5rVsPXia3jFqH.CbJ90cBywPdJTSrJS4WRI54eArgJKJmeLM07PcFcnNrWXqrBPzLnHkZNp9TEJ4FXKBApEvJ6FvkRoRB5pVw5Qxa7B5w.l4eXV678OcMMygceIS7C7esOajomxeemU3m5ACNeVaLJw0sIP1DgXJvNGWo3PoiQbZkGoUdACGTTx5565dPROmnDGe0brDA_MSbGf1ayfZ5jzEqPi1mNM9zXUywjYw.FlZQYYOVshniewHxI_xkgD9ANqGYhbhFBcNVopIthL_g22sL357a8xAPiPJKbB9jdU.rI05_fu_yNgwinzmji_wbODbocFJ91eL0xgtxWHWBToh4LymYFsOyG6TpoP4rzcxdqg.2HSXrrRK.ms5Br_750rJvuaT2gbqUTtOG3SGpIPsHvCSlDhVRp7hUjBdHgNhngOKQW5rmUEc7pdE0.n6zIER.lrkdL2M.3gaw.5l4.lKwSOhwj84pscKAySTeuRIXtmYbElKqQjgBQsUEbBJ3LlylgNJldZo5CWisx6mxGzNZGRYwam1KCwKyXdw8GuB0up5b48c2rMPBKgMC.yeIcDNHSGU3wkCiYtQrjPORxzx7auVU6v5Nb.NPKaig2ns1XOD9KXB8wf86M.xCcN7ILcPFvwm7j8QcWeur8z0HBRsVe1sOv11uFz8OC4wCaQ6MVaSSEUksSWldTLzvldq.eZy3Ops3OxDoLcOGXScb3tQzECExQ"};var cpo = document.createElement('script');cpo.src = '/cdn-cgi/challenge-platform/h/g/orchestrate/chl_page/v1?ray=8e6ff707ccd7ce31';window._cf_chl_opt.cOgUHash = location.hash === '' && location.href.indexOf('#') !== -1 ? '#' : location.hash;window._cf_chl_opt.cOgUQuery = location.search === '' && location.href.slice(0, location.href.length - window._cf_chl_opt.cOgUHash.length).indexOf('?') !== -1 ? '?' : location.search;if (window.history && window.history.replaceState) {var ogU = location.pathname + window._cf_chl_opt.cOgUQuery + window._cf_chl_opt.cOgUHash;history.replaceState(null, null, "\/doi\/10.1126\/science.aad1329?__cf_chl_rt_tk=eSr9TG_AB7tByJYkb9wj1ysSzVxWGc_xinqm6K2BKF8-1732352385-1.0.1.1-L53s3vybxgx1VzUra7TEi9YzAnYVmo4hTfSgzBEbruI" + window._cf_chl_opt.cOgUHash);cpo.onload = function() {history.replaceState(null, null, ogU);}}document.getElementsByTagName('head')[0].appendChild(cpo);}());</script></body></html>