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class="n2-ss-slide--focus" tabindex="-1">DNA + Protein</div><div class="n2-ss-layers-container n2-ss-slide-limiter n2-ow"><div class="n2-ss-layer n2-ow n-uc-jfRNeCzmVj9T" data-sstype="slide" data-pm="default"><div class="n2-ss-layer n2-ow n-uc-QQFpku7vSSRM" data-pm="default" data-sstype="content" data-hasbackground="0"><div class="n2-ss-section-main-content n2-ss-layer-with-background n2-ss-layer-content n2-ow n-uc-QQFpku7vSSRM-inner"><div class="n2-ss-layer n2-ow n2-ss-layer--block n2-ss-has-self-align n-uc-HeNbJQjtCgl0" data-pm="normal" data-sstype="row"><div class="n2-ss-layer-row n2-ss-layer-with-background n-uc-HeNbJQjtCgl0-inner"><div class="n2-ss-layer-row-inner "><div class="n2-ss-layer n2-ow n-uc-kOqYotRWB7Wg" data-pm="default" data-hidetabletportrait="1" data-hidemobileportrait="1" data-sstype="col"><div class="n2-ss-layer-col n2-ss-layer-with-background n2-ss-layer-content n-uc-kOqYotRWB7Wg-inner"></div></div><div class="n2-ss-layer n2-ow n-uc-6mioIbipVZwE" data-pm="default" data-hidemobileportrait="1" data-sstype="col"><div class="n2-ss-layer-col n2-ss-layer-with-background n2-ss-layer-content n-uc-6mioIbipVZwE-inner"></div></div><div class="n2-ss-layer n2-ow n-uc-0YZSxBvc39MP" data-pm="default" data-sstype="col"><div class="n2-ss-layer-col n2-ss-layer-with-background n2-ss-layer-content n-uc-0YZSxBvc39MP-inner"><div class="n2-ss-layer n2-ow n-uc-Ln8BgBJYggLo" data-pm="normal" data-sstype="layer"><h1 id="n2-ss-6item1" class="n2-font-70fd489f7531b6875668867099f53e68-hover n2-ss-item-content n2-ss-text n2-ow" style="display:block;">Find the key signatures of cancer through single-cell multi-omics.</h1></div><div class="n2-ss-layer n2-ow n-uc-uFRnPXFxHL01" data-pm="normal" data-sstype="layer"><div class="n2-ss-item-content n2-ss-text n2-ow-all"><div class=""><p class="n2-font-c9428e7d51b0ff6aa8a3a5d9bc3fefba-paragraph ">You seek more than patterns. You seek the sources of disease. The Tapestri Platform analyzes genotype and phenotype simultaneously from single cells, revealing the heterogeneity of your samples with unprecedented resolution. Leverage single-cell multi-omics to target comprehensive biomarkers that help stratify patients more precisely, signal resistance as it begins, and predict relapse.</p> </div></div></div><div class="n2-ss-layer n2-ow n2-ss-layer--block n2-ss-has-self-align n-uc-12572326d2905" data-pm="normal" data-sstype="row"><div class="n2-ss-layer-row n2-ss-layer-with-background n-uc-12572326d2905-inner"><div class="n2-ss-layer-row-inner "><div class="n2-ss-layer n2-ow n-uc-117b1ad10bbd9" data-pm="default" data-sstype="col"><div class="n2-ss-layer-col n2-ss-layer-with-background n2-ss-layer-content n-uc-117b1ad10bbd9-inner"><div class="n2-ss-layer n2-ow n-uc-twVddINDOvRX n2-ss-layer--auto" data-pm="normal" data-sstype="layer"><div class="n2-ss-button-container n2-ss-item-content n2-ow n2-font-46246db450cab399df1d2efca599e90c-link n2-ss-nowrap n2-ss-button-container--non-full-width"><a class="n2-style-27e077d11963793a3c40ec21dc495058-heading n2-ow v-lightbox" href="https://fast.wistia.net/embed/iframe/4dl5mog9cv?autoplay=true"><div><div>View Video</div></div></a></div></div></div></div><div class="n2-ss-layer n2-ow n-uc-10457146926dc" data-pm="default" data-sstype="col"><div class="n2-ss-layer-col n2-ss-layer-with-background n2-ss-layer-content n-uc-10457146926dc-inner"><div class="n2-ss-layer n2-ow n-uc-ELSy6Nn78Eeb n2-ss-layer--auto" data-pm="normal" data-sstype="layer"><div class="n2-ss-button-container n2-ss-item-content n2-ow n2-font-46246db450cab399df1d2efca599e90c-link n2-ss-nowrap n2-ss-button-container--non-full-width"><a class="n2-style-d1eec163d69a4d77eda3c8c8289ae95d-heading n2-ow ss3-btn-more-link" href="https://missionbio.com/resources/technical-notes/protein-correlations-application-note/"><div><div>Download App Note</div></div></a></div></div></div></div><div class="n2-ss-layer n2-ow n-uc-1ec4f3b9ad41a" data-pm="default" data-hidemobileportrait="1" data-sstype="col"><div class="n2-ss-layer-col n2-ss-layer-with-background n2-ss-layer-content n-uc-1ec4f3b9ad41a-inner"></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div> </div> </div> </div> </div> </div><ss3-loader></ss3-loader></div></div><div class="n2_clear"></div></div></ss3-force-full-width></div> <div class="panels-categories"> <div class="_1300-container inner-content capabilities-links"> <div class="panels-links"><a href="#Benefits" class="cap-link">Key Benefits</a> <a href="#Case-Study" class="cap-link">CASE聽STUDY</a> <a href="#Applications" class="cap-link">Applications</a> <a href="#Workflow" class="cap-link">Workflow</a> <a href="#Data" class="cap-link">DATASETS</a> <a href="#Resources" class="cap-link">RESOURCES</a> </div> </div> </div> <div id="Benefits" class="panels-section"> <div class="_1300-container inner-content key-benefits"> <h2 class="h2 c">Why DNA + Protein Single-cell Multi-omics?</h2> <div>Cancer is a complex disease with a mix of cells in varied states. Understanding the effect of genotype on immunophenotype at the single-cell level reveals disease processes and ultimately enables better therapies. A single-cell multi-omics approach is the only way to achieve full resolution of tumor heterogeneity. Perform true multi-omics with simultaneous detection of SNVs, CNVs, and cell-surface proteins at the single-cell level.</div> <p class="highlight-heading"></p> <div class="benefits-cols"> <div class="benefits-card"> <div class="benefit-content"> <img src="/wp-content/themes/missionbio-v2/images/Icon-Genome-Editing.svg" alt="DNA helix icon" class="benefit-icon"> <div>Correlate immunophenotype with genotype from the same cell.</div> </div> </div> <div class="benefits-card"> <div class="benefit-content"> <img src="/wp-content/themes/missionbio-v2/images/Icon-Solid-Tumor.svg" alt="cancer cell icon" class="benefit-icon"> <div>Distinguish subclones from minimal residual disease with single-cell multi-omics based on SNVs, CNVs, and protein expression.</div> </div> </div> <div class="benefits-card"> <div class="benefit-content"><img src="/wp-content/themes/missionbio-v2/images/Icon-Multi-omics.svg" alt="single cell with nucleus and DNA icon " class="benefit-icon"> <div>Eliminate inferences while saving on research budgets and analysis times.</div> </div> </div> </div> </div> </div> <div id="Case-Study" class="panels-section case-study testimonial"> <div class="_1300-container inner-content panels-details"> <div class="mission-cols"> <div class="application-image case-study" style="background-image: url(/wp-content/themes/missionbio-v2/images-2/people/ross-levine.png);"> <a href="https://www.youtube.com/watch?v=722LBD8fxnE" class="w-inline-block video-link v-lightbox"></a> </div> <div class="panel-col"> <img src="/wp-content/themes/missionbio-v2/images-2/logos/Memorial-Sloan-Kettering-Cancer-Center.svg" alt="Memorial Sloan Kettering Cancer Center>" class="case-logo"> <h2 class="h2-thin w">Explore insights of single-cell multi-omics in myeloid malignancies</h2> <p style="color: #FFF;" class="mb30">Ross Levine, MD, Memorial Sloan Kettering Cancer Center</p> <a href="https://www.youtube.com/watch?v=722LBD8fxnE" class="v-lightbox video-link button w w-button" style="width: auto; height: auto;"> Watch Video </a> </div> </div> </div> </div> <div id="Applications" class="panels-section margins"> <div class="applications-cols _1300"> <a href="/products/panels/" class="h-benefits-cols p w-inline-block" data-ix="applications-hover"> <div class="h-application-overlay"></div> <div class="h-application-content"> <div class="h-application-title">View Panels</div> <div>Target the diversity that matters with content in a custom panel, or start with one of our pre-designed panels.</div> <div class="more-link light">LEARN聽MORE</div> </div> </a> <a href="/applications/oncology/hematology/" class="h-benefits-cols h w-inline-block" data-ix="applications-hover"> <div class="h-application-overlay"></div> <div class="h-application-content"> <div class="h-application-title">Explore Hematology</div> <div>See how single-cell DNA sequencing transforms the study of hematological malignancies.</div> <div class="more-link light">LEARN聽MORE</div> </div> </a> </div> </div> <div id="Workflow" class="panels-section"> <div id="Workflow" class="_1300-container inner-content key-benefits"> <h2 class="h2 c">The Tapestri Workflow</h2> <p class="highlight-heading">Integrate seamlessly into your existing NGS workflow with sample prep and analysis solutions using the Tapestri single-cell sequencing platform</p> <div>With our single-cell sequencing platform, use the Tapestri Instrument, reagents, and consumables up-front of your NGS system and then Tapestri Pipeline and Tapestri Insights software for data analysis and visualization.</div> <div class="workflow"> <div class="workflow-col"> <div class="workflow-title">Target Selection</div> <div class="workflow-copy">Choose a <span class="nowrap">pre-designed</span> or custom DNA panel</div> <img src="/wp-content/themes/missionbio-v2/images/Icon-Target-2_1.svg" alt="primer and DNA fragment alignment icon" class="worflow-icon s"> <div class="workflow-links"> <a href="/products/panels/" class="worflow-links">Pre-designed DNA Panels</a> <a href="/products/panels/custom-panels/" class="worflow-links">Custom DNA Panels with Tapestri Designer</a> </div> </div> <div class="workflow-arrow"> <img src="/wp-content/themes/missionbio-v2/images/Workflow-Arrow.svg" alt=""> </div> <div class="workflow-col"> <div class="workflow-title">SAMPLE<br>PREP</div> <div class="workflow-copy">Add a protein panel and simple cell staining protocol</div> <img src="/wp-content/themes/missionbio-v2/images/Icon-Sample.svg" alt="microtube with mixed population of cells icon" class="worflow-icon"> <div class="workflow-links"> <a href="/products/panels/totalseq-d-heme-oncology/" class="worflow-links">Protein Panels</a> </div> </div> <div class="workflow-arrow"> <img src="/wp-content/themes/missionbio-v2/images/Workflow-Arrow.svg" alt=""> </div> <div class="workflow-col"> <div class="workflow-title">LIBRARY<br>PREP</div> <div class="workflow-copy">Single workflow combines DNA and protein panels</div> <img src="/wp-content/themes/missionbio-v2/images/Icon-Prep.svg" alt="Tapestri Platform icon" class="worflow-icon"> <div class="workflow-links"> <a href="/products/platform/" class="worflow-links">Tapestri Instrument</a> </div> </div> <div class="workflow-arrow"> <img src="/wp-content/themes/missionbio-v2/images/Workflow-Arrow.svg" alt=""> </div> <div class="workflow-col"> <div class="workflow-title">SEQUENCING</div> <div class="workflow-copy">Single sequencing run for <span class="nowrap">multi-omics</span> <span class="nowrap">single-cell</span> data</div> <img src="/wp-content/themes/missionbio-v2/images/Icon-Sequence.svg" alt="next-generation sequencing platform icon" class="worflow-icon"> <div class="workflow-links"></div> </div> <div class="workflow-arrow"> <img src="/wp-content/themes/missionbio-v2/images/Workflow-Arrow.svg" alt=""> </div> <div class="workflow-col"> <div class="workflow-title">PIPELINE</div> <div class="workflow-copy">Integrated pipeline for <span class="nowrap">multi-omics</span> analysis</div> <img src="/wp-content/themes/missionbio-v2/images/Icon-pipeline.svg" alt="Tapestri Pipeline Software icon" class="worflow-icon l"> <div class="workflow-links"> <a target="_blank" href="https://portal.missionbio.com" class="worflow-links">Tapestri Pipeline</a> </div> </div> <div class="workflow-arrow"> <img src="/wp-content/themes/missionbio-v2/images/Workflow-Arrow.svg" alt=""> </div> <div class="workflow-col"> <div class="workflow-title">ANALYSIS</div> <div class="workflow-copy">Powerful analysis and visualization software</div> <img src="/wp-content/themes/missionbio-v2/images/Icon-Analyze-V2.svg" alt="monitor with plots icon" class="worflow-icon l"> <div class="workflow-links"> <a target="_blank" href="https://portal.missionbio.com" class="worflow-links">Tapestri Insights</a> </div> </div> </div> </div> </div> <div id="Datasets" class="panels-section alt-bg"> <div id="Data" class="_1300-container inner-content key-benefits r"> <h2 class="h2 c">Datasets</h2> <p class="highlight-heading">Explore the datasets below using single-cell multi-omics analysis.</p> <div class="data-sets-wrap"> <div class="dataset-row t"> <div class="dataset-name t"> <div>NAME</div> </div> <div class="dataset-description t"> <div>DESCRIPTION</div> </div> <div class="dataset-date"> <div>LAST UPDATED</div> </div> </div> <div class="data-sets-wrap-content"> <div class="dataset-row"> <div class="dataset-name"> <a target="_blank" href="https://portal.missionbio.com/datasets/4-cell-lines-AML-multiomics">4 Cell Line Mix for SNV, CNV, and Protein Multi-omics Analysis</a> </div> <div class="dataset-description"> <div><p>Sample dataset for the Tapestri Single Cell DNA AML panel</p> </div> </div> <div class="dataset-date"> <div>12.22.2021</div> </div> </div> </div> </div> </div> </div> <div id="Capabilities" class="_1300-container inner-content capabilities home"> <div class="section-title-small">OTHER CAPABILITIES</div> <div class="red-devider mb"></div> <h2 class="h2">DNA Is Our Foundation</h2> <p>Providing cancer specialists with the only single-cell targeted DNA solution that integrates SNV, CNV, and protein data from the same cell.</p> <div class="h-capabilities-grid"> <div class="h-capabilities-col"> <div class="h-capabilities-titles"><img src="/wp-content/themes/missionbio-v2/images/Icon-Genomics.svg" alt="" class="icon"> <div class="h-capabilities-title">Single-cell Genomics (DNA)</div> </div> <div class="h-capabilities-sub-grid"> <div class="h-capabilities-sub-grid-col" data-ix="show-more-link"> <div class="h-capabilities-sub-grid-col-title">SNV</div> <div>Detect rare clonal populations and identify co-occurrence and zygosity.</div> <a href="/capabilities/snv/" class="more-link">LEARN聽MORE</a> </div> <div class="h-capabilities-divider half"></div> <div class="h-capabilities-sub-grid-col" data-ix="show-more-link"> <div class="h-capabilities-sub-grid-col-title">SNV + CNV</div> <div>Characterize genomic heterogeneity using a single comprehensive platform.</div> <a href="/capabilities/snv-cnv/" class="more-link">LEARN聽MORE</a> </div> </div> </div> </div> </div> <div id="Resources" class="h-resources"> <div class="_1300-container inner-content"> <h3 class="h3 w">Featured Resources</h3> <div class="h-resources-grid"> <div class="h-resource-card tn" data-ix="show-more-link"> <div class="h-resource-image tn" ></div> <div class="h-resource-content"> <div class="h-resource-category d tn">technical note</div> <a href="https://missionbio.com/resources/technical-notes/protein-correlations-application-note/" class="h-resource-title-link"> Correlations between genomic variants and protein expression in AML patient samples </a> <br /> <a href="https://missionbio.com/resources/technical-notes/protein-correlations-application-note/" class="more-link">LEARN聽MORE</a> </div> </div> <div class="h-resource-divider"></div> <div class="h-resource-card eb" data-ix="show-more-link"> <div class="h-resource-image eb" ></div> <div class="h-resource-content"> <div class="h-resource-category d eb">ebook</div> <a href="https://missionbio.com/resources/ebooks/single-cell-sequencing-101/" class="h-resource-title-link"> Single-cell Sequencing 101: DNA & multi-omics for precision medicine </a> <br /> <a href="https://missionbio.com/resources/ebooks/single-cell-sequencing-101/" class="more-link">LEARN聽MORE</a> </div> </div> <div class="h-resource-divider"></div> <div class="h-resource-card rs" data-ix="show-more-link"> <div class="h-resource-image rs" ></div> <div class="h-resource-content"> <div class="h-resource-category d rs">spotlight</div> <a href="https://missionbio.com/resources/spotlights/cummins-2019/" class="h-resource-title-link"> Immune-Based Therapies for Hematology: Single-cell Multi-omics and Cell Therapies for Leukemias </a> <br /> <a href="https://missionbio.com/resources/spotlights/cummins-2019/" class="more-link">LEARN聽MORE</a> </div> </div> <div class="h-resource-divider"></div> </div> 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