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href="/w/index.php?title=%E0%AC%AC%E0%AC%BF%E0%AC%B6%E0%AD%87%E0%AC%B7:%E0%AC%96%E0%AC%BE%E0%AC%A4%E0%AC%BE%E0%AC%96%E0%AD%8B%E0%AC%B2%E0%AC%BF%E0%AC%AC%E0%AD%87&returnto=%E0%AC%86%E0%AC%AB%E0%AC%BE%E0%AC%9F%E0%AC%BF%E0%AC%A8%E0%AC%BF%E0%AC%AC&returntoquery=printable%3Dyes" title="ଆପଣଙ୍କୁ ଗୋଟେ ଖାତା ଖୋଲି ଲଗ ଇନ କରିବା ପାଇଁ ପ୍ରୋତ୍ସାହିତ କରାଯାଉଛି, ଏମିତିବି ଏହା କରିବା ନିତାନ୍ତ ଆବଶ୍ୟକ ନୁହେଁ ।" class=""><span>ଖାତାଟିଏ ଖୋଲନ୍ତୁ</span></a> </li> <li id="pt-login-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="/w/index.php?title=%E0%AC%AC%E0%AC%BF%E0%AC%B6%E0%AD%87%E0%AC%B7:%E0%AC%B8%E0%AC%AD%E0%AD%8D%E0%AD%9F%E0%AC%B2%E0%AC%97%E0%AC%87%E0%AC%A8&returnto=%E0%AC%86%E0%AC%AB%E0%AC%BE%E0%AC%9F%E0%AC%BF%E0%AC%A8%E0%AC%BF%E0%AC%AC&returntoquery=printable%3Dyes" title="ଆପଣଙ୍କୁ ଲଗ-ଇନ କରିବାକୁ କୁହାଯାଉଅଛି ସିନା, ବାଧ୍ୟ କରାଯାଉନାହିଁ [o]" accesskey="o" class=""><span>ଲଗ-ଇନ</span></a> </li> </ul> </div> </div> </div> <div id="vector-user-links-dropdown" 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<h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">ଆଫାଟିନିବ</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Go to an article in another language. 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href="https://de.wikipedia.org/wiki/Afatinib" title="Afatinib – ଜର୍ମାନ" lang="de" hreflang="de" data-title="Afatinib" data-language-autonym="Deutsch" data-language-local-name="ଜର୍ମାନ" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Afatinib" title="Afatinib – ଇଂରାଜୀ" lang="en" hreflang="en" data-title="Afatinib" data-language-autonym="English" data-language-local-name="ଇଂରାଜୀ" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Afatinib" title="Afatinib – ସ୍ପେନିୟ" lang="es" hreflang="es" data-title="Afatinib" data-language-autonym="Español" data-language-local-name="ସ୍ପେନିୟ" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D8%A2%D9%81%D8%A7%D8%AA%DB%8C%D9%86%DB%8C%D8%A8" title="آفاتینیب – ପର୍ସିଆନ୍" lang="fa" hreflang="fa" data-title="آفاتینیب" data-language-autonym="فارسی" data-language-local-name="ପର୍ସିଆନ୍" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Afatinibi" title="Afatinibi – ଫିନ୍ନିସ୍" lang="fi" hreflang="fi" data-title="Afatinibi" data-language-autonym="Suomi" data-language-local-name="ଫିନ୍ନିସ୍" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Afatinib" title="Afatinib – ଫରାସୀ" lang="fr" hreflang="fr" data-title="Afatinib" data-language-autonym="Français" data-language-local-name="ଫରାସୀ" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Afatinib" title="Afatinib – ଇଟାଲୀୟ" lang="it" hreflang="it" data-title="Afatinib" data-language-autonym="Italiano" data-language-local-name="ଇଟାଲୀୟ" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%82%A2%E3%83%95%E3%82%A1%E3%83%81%E3%83%8B%E3%83%96" title="アファチニブ – ଜାପାନୀ" lang="ja" hreflang="ja" data-title="アファチニブ" data-language-autonym="日本語" data-language-local-name="ଜାପାନୀ" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Afatynib" title="Afatynib – ପୋଲିଶ୍" lang="pl" hreflang="pl" data-title="Afatynib" data-language-autonym="Polski" data-language-local-name="ପୋଲିଶ୍" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Afatinib" title="Afatinib – ସର୍ବୋ-କ୍ରୋଆଟିଆନ୍" lang="sh" hreflang="sh" data-title="Afatinib" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="ସର୍ବୋ-କ୍ରୋଆଟିଆନ୍" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-sl mw-list-item"><a href="https://sl.wikipedia.org/wiki/Afatinib" title="Afatinib – ସ୍ଲୋଭେନିଆନ୍" lang="sl" hreflang="sl" data-title="Afatinib" data-language-autonym="Slovenščina" data-language-local-name="ସ୍ଲୋଭେନିଆନ୍" class="interlanguage-link-target"><span>Slovenščina</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Afatinib" title="Afatinib – ସର୍ବିୟ" lang="sr" hreflang="sr" data-title="Afatinib" data-language-autonym="Српски / srpski" data-language-local-name="ସର୍ବିୟ" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%90%D1%84%D0%B0%D1%82%D0%B8%D0%BD%D1%96%D0%B1" title="Афатиніб – ୟୁକ୍ରାନିଆନ୍" lang="uk" hreflang="uk" data-title="Афатиніб" data-language-autonym="Українська" data-language-local-name="ୟୁକ୍ରାନିଆନ୍" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-vi mw-list-item"><a href="https://vi.wikipedia.org/wiki/Afatinib" title="Afatinib – ଭିଏତନାମିଜ୍" lang="vi" hreflang="vi" data-title="Afatinib" data-language-autonym="Tiếng Việt" data-language-local-name="ଭିଏତନାମିଜ୍" class="interlanguage-link-target"><span>Tiếng Việt</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E9%98%BF%E6%B3%95%E6%9B%BF%E5%B0%BC" title="阿法替尼 – ଚାଇନିଜ୍‌" lang="zh" hreflang="zh" data-title="阿法替尼" data-language-autonym="中文" data-language-local-name="ଚାଇନିଜ୍‌" class="interlanguage-link-target"><span>中文</span></a></li> </ul> <div class="after-portlet 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print{body.ns-0 .mw-parser-output .hatnote{display:none!important}}</style><div role="note" class="hatnote navigation-not-searchable">Not to be confused with <a href="/w/index.php?title=Apatinib&action=edit&redlink=1" class="new" title="Apatinib (ପୃଷ୍ଠାଟି ନାହିଁ)">apatinib</a>.</div><style data-mw-deduplicate="TemplateStyles:r488502">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}body.skin-minerva .mw-parser-output .infobox-header,body.skin-minerva .mw-parser-output .infobox-subheader,body.skin-minerva .mw-parser-output .infobox-above,body.skin-minerva .mw-parser-output .infobox-title,body.skin-minerva .mw-parser-output .infobox-image,body.skin-minerva .mw-parser-output .infobox-full-data,body.skin-minerva .mw-parser-output .infobox-below{text-align:center}</style><table class="infobox" style="border-spacing:2px;"><caption class="infobox-title"><span title="International nonproprietary name (INN): ଆଫାଟିନିବ">ଆଫାଟିନିବ</span></caption><tbody><tr><td colspan="2" class="infobox-image"><span class="mw-default-size" typeof="mw:File/Frameless"><a href="/wiki/%E0%AC%AB%E0%AC%BE%E0%AC%87%E0%AC%B2:Afatinib2DACS.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a1/Afatinib2DACS.svg/220px-Afatinib2DACS.svg.png" decoding="async" width="220" height="146" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a1/Afatinib2DACS.svg/330px-Afatinib2DACS.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a1/Afatinib2DACS.svg/440px-Afatinib2DACS.svg.png 2x" data-file-width="512" data-file-height="340" /></a></span></td></tr><tr><td colspan="2" class="infobox-image"><span class="mw-default-size" typeof="mw:File/Frameless"><a href="/wiki/%E0%AC%AB%E0%AC%BE%E0%AC%87%E0%AC%B2:Afatinib_3D_ball-and-stick_4G5P.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/1/1b/Afatinib_3D_ball-and-stick_4G5P.png/220px-Afatinib_3D_ball-and-stick_4G5P.png" decoding="async" width="220" height="194" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/1b/Afatinib_3D_ball-and-stick_4G5P.png/330px-Afatinib_3D_ball-and-stick_4G5P.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/1b/Afatinib_3D_ball-and-stick_4G5P.png/440px-Afatinib_3D_ball-and-stick_4G5P.png 2x" data-file-width="2000" data-file-height="1764" /></a></span></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Clinical data</th></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/w/index.php?title=Drug_nomenclature&action=edit&redlink=1" class="new" title="Drug nomenclature (ପୃଷ୍ଠାଟି ନାହିଁ)">Trade names</a></th><td class="infobox-data">Gilotrif, Giotrif, Afanix</td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;">Synonyms</th><td class="infobox-data">BIBW 2992</td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/w/index.php?title=American_Society_of_Health-System_Pharmacists&action=edit&redlink=1" class="new" title="American Society of Health-System Pharmacists (ପୃଷ୍ଠାଟି ନାହିଁ)">AHFS</a>/<a href="/w/index.php?title=Drugs.com&action=edit&redlink=1" class="new" title="Drugs.com (ପୃଷ୍ଠାଟି ନାହିଁ)">Drugs.com</a></th><td class="infobox-data"><span class="reflink plainlinks nourlexpansion"><a rel="nofollow" class="external text" href="https://www.drugs.com/monograph/afatinib-dimaleate.html">monograph</a></span></td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/w/index.php?title=MedlinePlus&action=edit&redlink=1" class="new" title="MedlinePlus (ପୃଷ୍ଠାଟି ନାହିଁ)">MedlinePlus</a></th><td class="infobox-data"><span title="medlineplus.gov"><a rel="nofollow" class="external text" href="https://medlineplus.gov/druginfo/meds/a613044.html">a613044</a></span></td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/w/index.php?title=Regulation_of_therapeutic_goods&action=edit&redlink=1" class="new" title="Regulation of therapeutic goods (ପୃଷ୍ଠାଟି ନାହିଁ)"> data</a></th><td class="infobox-data"><div class="plainlist"> <ul><li><small><abbr title="European Union">EU</abbr></small> <a href="/w/index.php?title=European_Medicines_Agency&action=edit&redlink=1" class="new" title="European Medicines Agency (ପୃଷ୍ଠାଟି ନାହିଁ)">EMA</a>: <span title="www.ema.europa.eu"><a rel="nofollow" class="external text" href="http://www.ema.europa.eu/ema/index.jsp?curl=%2Fpages%2Fmedicines%2Flanding%2Fepar_search.jsp&mid=&searchTab=searchByKey&alreadyLoaded=true&isNewQuery=true&status=Authorised&status=Withdrawn&status=Suspended&status=Refused&keywordSearch=Submit&searchType=name&taxonomyPath=&treeNumber=&searchGenericType=generics&keyword=yes">yes</a></span></li> <li><small><abbr title="United States">US</abbr></small> <a href="/w/index.php?title=DailyMed&action=edit&redlink=1" class="new" title="DailyMed (ପୃଷ୍ଠାଟି ନାହିଁ)">DailyMed</a>: <span title="dailymed.nlm.nih.gov"><a rel="nofollow" class="external text" href="https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=Afatinib">Afatinib</a></span></li></ul></div> </td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/w/index.php?title=Pregnancy_category&action=edit&redlink=1" class="new" title="Pregnancy category (ପୃଷ୍ଠାଟି ନାହିଁ)">Pregnancy<br />category</a></th><td class="infobox-data"><div class="plainlist"> <ul><li><small><abbr title="Australia">AU</abbr>:</small> <a href="/w/index.php?title=Pregnancy_category&action=edit&redlink=1" class="new" title="Pregnancy category (ପୃଷ୍ଠାଟି ନାହିଁ)">C</a> </li></ul> <ul><li class="mw-empty-elt"></li></ul> </div></td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/w/index.php?title=Route_of_administration&action=edit&redlink=1" class="new" title="Route of administration (ପୃଷ୍ଠାଟି ନାହିଁ)">Routes of<br />administration</a></th><td class="infobox-data"><a href="/w/index.php?title=Oral_administration&action=edit&redlink=1" class="new" title="Oral administration (ପୃଷ୍ଠାଟି ନାହିଁ)">By mouth</a></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Legal status</th></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/w/index.php?title=Regulation_of_therapeutic_goods&action=edit&redlink=1" class="new" title="Regulation of therapeutic goods (ପୃଷ୍ଠାଟି ନାହିଁ)">Legal status</a></th><td class="infobox-data"><div class="plainlist"> <ul><li><small><abbr title="Australia">AU</abbr>:</small> <a href="/w/index.php?title=Standard_for_the_Uniform_Scheduling_of_Drugs_and_Poisons&action=edit&redlink=1" class="new" title="Standard for the Uniform Scheduling of Drugs and Poisons (ପୃଷ୍ଠାଟି ନାହିଁ)">S4</a> (Prescription only) </li> <li><small><abbr title="Canada">CA</abbr></small>: <a href="/w/index.php?title=Prescription_drug&action=edit&redlink=1" class="new" title="Prescription drug (ପୃଷ୍ଠାଟି ନାହିଁ)"> ℞-only</a> </li> <li><small><abbr title="United Kingdom">UK</abbr>:</small> <a href="/w/index.php?title=Prescription_drug&action=edit&redlink=1" class="new" title="Prescription drug (ପୃଷ୍ଠାଟି ନାହିଁ)">POM</a> (Prescription only) </li> <li><small><abbr title="United States">US</abbr>:</small> <a href="/w/index.php?title=Prescription_drug&action=edit&redlink=1" class="new" title="Prescription drug (ପୃଷ୍ଠାଟି ନାହିଁ)">℞-only</a> <sup id="cite_ref-PI2022_1-0" class="reference"><a href="#cite_note-PI2022-1"><span class="cite-bracket">[</span>୧<span class="cite-bracket">]</span></a></sup></li> <li><small><abbr title="European Union">EU</abbr>:</small> Rx-only </li></ul></div> </td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd"><a href="/w/index.php?title=Pharmacokinetics&action=edit&redlink=1" class="new" title="Pharmacokinetics (ପୃଷ୍ଠାଟି ନାହିଁ)">Pharmacokinetic</a> data</th></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/w/index.php?title=Plasma_protein_binding&action=edit&redlink=1" class="new" title="Plasma protein binding (ପୃଷ୍ଠାଟି ନାହିଁ)">Protein binding</a></th><td class="infobox-data">95%</td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/w/index.php?title=Drug_metabolism&action=edit&redlink=1" class="new" title="Drug metabolism (ପୃଷ୍ଠାଟି ନାହିଁ)">Metabolism</a></th><td class="infobox-data"><a href="/w/index.php?title=Cytochrome_P450&action=edit&redlink=1" class="new" title="Cytochrome P450 (ପୃଷ୍ଠାଟି ନାହିଁ)">CYP</a> not involved</td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/w/index.php?title=Biological_half-life&action=edit&redlink=1" class="new" title="Biological half-life (ପୃଷ୍ଠାଟି ନାହିଁ)">Elimination <span class="nowrap">half-life</span></a></th><td class="infobox-data">37 hours</td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/w/index.php?title=Excretion&action=edit&redlink=1" class="new" title="Excretion (ପୃଷ୍ଠାଟି ନାହିଁ)">Excretion</a></th><td class="infobox-data">Faeces (85%), urine (4%)</td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Identifiers</th></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/w/index.php?title=IUPAC_nomenclature_of_chemistry&action=edit&redlink=1" class="new" title="IUPAC nomenclature of chemistry (ପୃଷ୍ଠାଟି ନାହିଁ)">IUPAC name</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all; text-align:left; padding-left:1.5em; text-indent:-1.5em;"><li style="line-height: inherit; margin: 0"><span style="font-size: 11px;"><i>N</i>-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3<i>S</i>)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4(dimethylamino)-2-butenamide</span></li></ul> </div></td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/w/index.php?title=ECHA_InfoCard&action=edit&redlink=1" class="new" title="ECHA InfoCard (ପୃଷ୍ଠାଟି ନାହିଁ)"><span title="echa.europa.eu">ECHA InfoCard</span></a></th><td class="infobox-data"><a rel="nofollow" class="external text" href="https://echa.europa.eu/substance-information/-/substanceinfo/100.239.035">100.239.035</a> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q4688818#P2566" title="Edit this at Wikidata"><img alt="Edit this at Wikidata" src="//upload.wikimedia.org/wikipedia/commons/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Chemical and physical data</th></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/w/index.php?title=Chemical_formula&action=edit&redlink=1" class="new" title="Chemical formula (ପୃଷ୍ଠାଟି ନାହିଁ)">Formula</a></th><td class="infobox-data"><span title="Carbon">C</span><sub>24</sub><span title="Hydrogen">H</span><sub>25</sub><span title="Chlorine">Cl</span><span title="Fluorine">F</span><span title="Nitrogen">N</span><sub>5</sub><span title="Oxygen">O</span><sub>3</sub></td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/w/index.php?title=Molar_mass&action=edit&redlink=1" class="new" title="Molar mass (ପୃଷ୍ଠାଟି ନାହିଁ)">Molar mass</a></th><td class="infobox-data">୪୮୫.୯୪ g·mol<sup>−1</sup></td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;">3D model (<a href="/w/index.php?title=JSmol&action=edit&redlink=1" class="new" title="JSmol (ପୃଷ୍ଠାଟି ନାହିଁ)">JSmol</a>)</th><td class="infobox-data"><style data-mw-deduplicate="TemplateStyles:r489528">.mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}</style><div class="plainlist"><ul><li><span title="chemapps.stolaf.edu (3D interactive model)"><a rel="nofollow" class="external text" href="http://chemapps.stolaf.edu/jmol/jmol.php?model=CN%28C%29C%5CC%3DC%5CC%28%3DO%29Nc3cc1c%28Nc%28cc2Cl%29ccc2F%29ncnc1cc3OC4COCC4">Interactive image</a></span></li></ul></div></td></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/w/index.php?title=Simplified_molecular-input_line-entry_system&action=edit&redlink=1" class="new" title="Simplified molecular-input line-entry system (ପୃଷ୍ଠାଟି ନାହିଁ)">SMILES</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:11px; line-height:120%;">CN(C)C\C=C\C(=O)Nc3cc1c(Nc(cc2Cl)ccc2F)ncnc1cc3OC4COCC4</div></li></ul> </div></td></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/w/index.php?title=International_Chemical_Identifier&action=edit&redlink=1" class="new" title="International Chemical Identifier (ପୃଷ୍ଠାଟି ନାହିଁ)">InChI</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:11px; line-height:120%;">InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1<sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></div></li><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:11px; line-height:120%;">Key:ULXXDDBFHOBEHA-CWDCEQMOSA-N<sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></div></li></ul> </div></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd"><style data-mw-deduplicate="TemplateStyles:r467594">.mw-parser-output .nobold{font-weight:normal}</style><span class="nobold">  <span class="reflink plainlinks nourlexpansion"><a class="external text" href="https://or.wikipedia.org/w/index.php?title=%E0%AC%AC%E0%AC%BF%E0%AC%B6%E0%AD%87%E0%AC%B7:ComparePages&rev1=645735594&page2=%E0%AC%86%E0%AC%AB%E0%AC%BE%E0%AC%9F%E0%AC%BF%E0%AC%A8%E0%AC%BF%E0%AC%AC">(verify)</a></span></span></th></tr></tbody></table> <p><b>ଆଫାଟିନିବ,</b> ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେଏକ ବେପାର ନାମ <b>ଗିଲୋଟ୍ରିଫ୍,</b> ହେଉଛି ଏକ ଔଷଧ ଯାହା ଅଣ-ଛୋଟ କୋଷ ଫୁସଫୁସ କର୍କଟ (NSCLC) ରୋଗର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ । <sup id="cite_ref-PI2022_1-1" class="reference"><a href="#cite_note-PI2022-1"><span class="cite-bracket">[</span>୧<span class="cite-bracket">]</span></a></sup> ଏହା ମୁଖ୍ୟତଃ ଏକ ଅଣ-ପ୍ରତିରୋଧକ ଏପିଡର୍ମାଲ୍ ଅଭିବୃଦ୍ଧି ଫ୍ୟାକ୍ଟର୍ ରିସେପ୍ଟର (EGFR) ମ୍ୟୁଟେସନ୍ ସହିତ ଆଗେଇ ଯାଇଥିବା ରୋଗରେ ବ୍ୟବହୃତ ହୁଏ । <sup id="cite_ref-PI2022_1-2" class="reference"><a href="#cite_note-PI2022-1"><span class="cite-bracket">[</span>୧<span class="cite-bracket">]</span></a></sup> ଏହା ପାଟିରେ ଦିଆଯାଏ । <sup id="cite_ref-PI2022_1-3" class="reference"><a href="#cite_note-PI2022-1"><span class="cite-bracket">[</span>୧<span class="cite-bracket">]</span></a></sup> </p><p>ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ତରଳ ଝାଡ଼ା, ରାସ, ପାଟି ପ୍ରଦାହ, ଶୁଷ୍କ ଚର୍ମ, ବାନ୍ତି, ଏବଂ ଗଲୁ ହୋଇପାରେ । <sup id="cite_ref-PI2022_1-4" class="reference"><a href="#cite_note-PI2022-1"><span class="cite-bracket">[</span>୧<span class="cite-bracket">]</span></a></sup> ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଇଣ୍ଟରସ୍ଟିସିଆଲ୍ ଫୁସଫୁସ ରୋଗ, ଯକୃତ ସମସ୍ୟା, <a href="/wiki/%E0%AC%9C%E0%AC%A0%E0%AC%B0%E0%AC%BE%E0%AC%A8%E0%AD%8D%E0%AC%A4%E0%AD%8D%E0%AC%B0_%E0%AC%9B%E0%AC%BF%E0%AC%A6%E0%AD%8D%E0%AC%B0" title="ଜଠରାନ୍ତ୍ର ଛିଦ୍ର">ଜଠରାନ୍ତ୍ର ଛିଦ୍ର,</a> ଏବଂ କର୍ଣ୍ଣିଆ ପ୍ରଦାହ ହୋଇପାରେ। <sup id="cite_ref-PI2022_1-5" class="reference"><a href="#cite_note-PI2022-1"><span class="cite-bracket">[</span>୧<span class="cite-bracket">]</span></a></sup> ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର ଶିଶୁର କ୍ଷତି କରିପାରେ । <sup id="cite_ref-PI2022_1-6" class="reference"><a href="#cite_note-PI2022-1"><span class="cite-bracket">[</span>୧<span class="cite-bracket">]</span></a></sup> ଏହା ଏକ ଟାଇରୋସିନ୍ କାଇନେଜ ଇନହିବିଟର ଯାହା ପ୍ରୋଟିନର ଏରବିବି ପରିବାରକୁ ଅବରୋଧ କରି କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ । <sup id="cite_ref-EPAR2022_2-0" class="reference"><a href="#cite_note-EPAR2022-2"><span class="cite-bracket">[</span>୨<span class="cite-bracket">]</span></a></sup> <sup id="cite_ref-AHFS2022_3-0" class="reference"><a href="#cite_note-AHFS2022-3"><span class="cite-bracket">[</span>୩<span class="cite-bracket">]</span></a></sup> </p><p>୨୦୧୩ ମସିହାରେ ଆମେରିକା ଏବଂ ୟୁରୋପରେ ଡାକ୍ତରୀ ବ୍ୟବହାର ପାଇଁ ଅନୁମୋଦନ <a href="/wiki/%E0%AC%8F%E0%AC%B0%E0%AD%8D%E0%AC%B2%E0%AD%8B%E0%AC%9F%E0%AC%BF%E0%AC%A8%E0%AC%BF%E0%AC%AC" title="ଏର୍ଲୋଟିନିବ">କରାଯାଇଥିଲା</a> ।<sup id="cite_ref-PI2022_1-7" class="reference"><a href="#cite_note-PI2022-1"><span class="cite-bracket">[</span>୧<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-EPAR2022_2-1" class="reference"><a href="#cite_note-EPAR2022-2"><span class="cite-bracket">[</span>୨<span class="cite-bracket">]</span></a></sup> ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଅତ୍ୟାବଶ୍ୟକୀୟ ତାଲିକାରରେ ଏହାର ନାମ ଏର୍ଲୋଟିନିବ ବିନିମୟରେ ଅଛି ।<sup id="cite_ref-WHO22nd_4-0" class="reference"><a href="#cite_note-WHO22nd-4"><span class="cite-bracket">[</span>୪<span class="cite-bracket">]</span></a></sup> ଯୁକ୍ତରାଜ୍ୟରେ ୪ ସପ୍ତାହ ଖର୍ଚ୍ଚର ମୂଲ୍ୟ ୨୦୨୧ ସୁଦ୍ଧା ପ୍ରାୟ ୨,୦୦୦ ପାଉଣ୍ଡ ଥିଲା । <sup id="cite_ref-BNF81_5-0" class="reference"><a href="#cite_note-BNF81-5"><span class="cite-bracket">[</span>୫<span class="cite-bracket">]</span></a></sup> ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ରାଶି ପ୍ରାୟ ୯,୮୦୦ ଡଲାର ଅଟେ । <sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>୬<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="ଆଧାର"><span id=".E0.AC.86.E0.AC.A7.E0.AC.BE.E0.AC.B0"></span>ଆଧାର</h2></div> <ol class="references"> <li id="cite_note-PI2022-1"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-PI2022_1-0">୧.୦</a></sup> <sup><a href="#cite_ref-PI2022_1-1">୧.୧</a></sup> <sup><a href="#cite_ref-PI2022_1-2">୧.୨</a></sup> <sup><a href="#cite_ref-PI2022_1-3">୧.୩</a></sup> <sup><a href="#cite_ref-PI2022_1-4">୧.୪</a></sup> <sup><a href="#cite_ref-PI2022_1-5">୧.୫</a></sup> <sup><a href="#cite_ref-PI2022_1-6">୧.୬</a></sup> <sup><a href="#cite_ref-PI2022_1-7">୧.୭</a></sup></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r485312">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free a,.mw-parser-output .citation .cs1-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited a,.mw-parser-output .id-lock-registration a,.mw-parser-output .citation .cs1-lock-limited a,.mw-parser-output .citation .cs1-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output 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href="http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=fd638e5e-8032-e7ca-0179-95e96ab5d387">"Gilotrif (afatinib) tablet, film coated"</a>. <i>DailyMed</i>. Boehringer Ingelheim Pharmaceuticals, Inc. 18 October 2019. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20140202100631/http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=fd638e5e-8032-e7ca-0179-95e96ab5d387">Archived</a> from the original on 2 February 2014<span class="reference-accessdate">. Retrieved <span class="nowrap">4 November</span> 2020</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=DailyMed&rft.atitle=Gilotrif+%28afatinib%29+tablet%2C+film+coated&rft.date=2019-10-18&rft_id=http%3A%2F%2Fdailymed.nlm.nih.gov%2Fdailymed%2Flookup.cfm%3Fsetid%3Dfd638e5e-8032-e7ca-0179-95e96ab5d387&rfr_id=info%3Asid%2For.wikipedia.org%3A%E0%AC%86%E0%AC%AB%E0%AC%BE%E0%AC%9F%E0%AC%BF%E0%AC%A8%E0%AC%BF%E0%AC%AC" class="Z3988"></span></span> </li> <li id="cite_note-EPAR2022-2"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-EPAR2022_2-0">୨.୦</a></sup> <sup><a href="#cite_ref-EPAR2022_2-1">୨.୧</a></sup></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r485312"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20211122105016/https://www.ema.europa.eu/en/medicines/human/EPAR/giotrif">"Giotrif"</a>. Archived from <a rel="nofollow" class="external text" href="https://www.ema.europa.eu/en/medicines/human/EPAR/giotrif">the original</a> on 22 November 2021<span class="reference-accessdate">. Retrieved <span class="nowrap">13 January</span> 2022</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Giotrif&rft_id=https%3A%2F%2Fwww.ema.europa.eu%2Fen%2Fmedicines%2Fhuman%2FEPAR%2Fgiotrif&rfr_id=info%3Asid%2For.wikipedia.org%3A%E0%AC%86%E0%AC%AB%E0%AC%BE%E0%AC%9F%E0%AC%BF%E0%AC%A8%E0%AC%BF%E0%AC%AC" class="Z3988"></span></span> </li> <li id="cite_note-AHFS2022-3"><span class="mw-cite-backlink"><a href="#cite_ref-AHFS2022_3-0">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r485312"><cite class="citation web cs1 cs1-prop-foreign-lang-source"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20211210204157/https://www.drugs.com/monograph/afatinib.html">"Afatinib Monograph for Professionals"</a>. <i>Drugs.com</i> (in ଇଂରାଜୀ). Archived from <a rel="nofollow" class="external text" href="https://www.drugs.com/monograph/afatinib.html">the original</a> on 10 December 2021<span class="reference-accessdate">. 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Geneva: World Health Organization. <a href="/w/index.php?title=Hdl_(identifier)&action=edit&redlink=1" class="new" title="Hdl (identifier) (ପୃଷ୍ଠାଟି ନାହିଁ)">hdl</a>:<span class="cs1-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://hdl.handle.net/10665%2F345533">10665/345533</a></span>. 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