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menu-item-type-post_type menu-item-object-page menu-item-458"><a href="https://verismotherapeutics.com/join-us/">Join Us</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-228"><a href="https://verismotherapeutics.com/contact/">Contact</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-710"><a href="https://verismotherapeutics.com/for-patients/">For Patients</a></li> </ul> </div> <div id="header_clear" ></div> <div id="content_wrapper"> <style> .page_top_brg{ background-image: url('https://verismotherapeutics.com/wp-content/uploads/2022/09/science-banner-v2-scaled.jpg'); } </style> <div id="page_top" > <div class="page_top_brg"></div> <div class="container"> <div class="row align-items-center hasBannerImage"> <div class="col-12 col-md-6 col-lg-5"> <h1> Revolutionizing the Treatment of Solid Tumors </h1> </div> </div> </div> </div><div class="single-page" id="Science-Page"> <section id="sci-r1" class="lightblue"> <div class="container"> <div class="row justify-content-center"> <div class="col-12 col-md-9 text-center"> <h2>What Makes SynKIR™ Uniquely Effective</h2> <p>SynKIR™ is a CAR T cell therapy that uses a novel KIR-CAR platform technology to transform the treatment of solid tumors via a nature-inspired multichain receptor.</p> </div> </div> <div class="row"> <div class="col-12 col-md-6 mb-4 sci-col text-center"> <p><img decoding="async" class="aligncenter size-full wp-image-253" style="display: inline-block;" src="https://verismotherapeutics.com/wp-content/uploads/2022/10/sci-diag1-10-6.png" /></p> <h3>Designed to Decouple when at rest</h3> <p>The independent binding and signal chains are designed to separate tumor binding from T cell activation and demonstrate long-term T cell function.</p> </div> <div class="col-12 col-md-6 sci-col text-center"> <p><img decoding="async" class="aligncenter size-full wp-image-258" src="https://verismotherapeutics.com/wp-content/uploads/2022/10/sci-diag2-10-6.png" /></p> <h3>… AND COUPLE WHEN TUMOR IS ENGAGED</h3> <p>The dual binding and signal chains are designed to come together to form a single receptor complex when bound to a tumor target. Dual chain signaling provides prolonged T cell activation even in challenging solid-tumor environments.</p> </div> </div> </div> </section> <section class="sci-r2"> <div class="container"> <div class="row"> <div class="col-12 text-center text-md-right mb-5 pb-5"> <h2>Inspired by Nature.<br /> Engineered to Perfection.</h2> </div> <div class="col-12 sci-repeater-single scir-1"> <div class="srs-content"> <div class="srs-c-inner"> <h4>Natural Switch Design for Solid Tumors</h4> <p>The KIR-CAR platform (SynKIR™) is the first CAR T cell therapy with long-term T cell functionality. Its naturally-inspired unique structure designed to couple and decouple to allow T cells to remain effective even under repeated tumor encounters in the harshest of solid tumor microenvironments.</p> </div> </div> <div class="srs-image"> <img src="https://verismotherapeutics.com/wp-content/uploads/2022/09/sci-dia-1-v2.png"> </div> </div> <div class="col-12 sci-repeater-single scir-2"> <div class="srs-content"> <div class="srs-c-inner"> <h4>Powerful Parallel Activation Pathway Independent of Costimulation</h4> <p>SynKIR™ uses a parallel DAP12 activation pathway, bypassing the high-traffic CD3-ζ pathway used by CAR and TCR T cell therapies. In preclinical in vivo studies, SynKIR™ T cells maintained activation and potent cytotoxic activities in solid tumors compared with the CD28 and 4-1BB co-stimulated CD3-ζ -based traditional CAR T cells. The DAP12 signal functions as both activation and co-stimulation for T cells, circumventing the CD3-ζ pathway to allow prolonged KIR-CAR function.</p> </div> </div> <div class="srs-image"> <img src="https://verismotherapeutics.com/wp-content/uploads/2022/09/sci-diag-2-v3.png"> </div> </div> <div class="col-12 sci-repeater-single scir-3"> <div class="srs-content"> <div class="srs-c-inner"> <h4>Long-term T Cell Function & Sustained Efficacy in Aggressive Tumor Models</h4> <p>Inspired by Natural Killer (NK) cell Killer Immunoglobulin-like Receptors (KIR), SynKIR™ provides a naturally-induced stimulation to T cells. This more natural signaling is designed to prolong KIR-CAR T cells’ efficacy period by coupling the receptor chains during activation and decoupling them during rest, avoiding T cell exhaustion. SynKIR™ has shown sustained efficacy in CAR T-resistant mouse models of mesothelioma and glioblastoma leading to complete tumor remissions.</p> </div> </div> <div class="srs-image"> <img src=""> </div> </div> <div class="col-12 sci-repeater-single scir-4"> <div class="srs-content"> <div class="srs-c-inner"> <h4>Enhanced Surface Stability</h4> <p>KIR-CARs have shown long-term sustained receptor expression on both activated and resting T cell surfaces. This sustained KIR-CAR expression coincides with ongoing continued anti-tumor functions, even in demanding solid tumor microenvironments. As a result, KIR-CAR T cells have shown superior anti-tumor function including complete tumor eradications in mouse models where CD3-ζ-based CAR T have failed.</p> </div> </div> <div class="srs-image"> <img src=""> </div> </div> <div class="col-12 sci-repeater-single scir-5"> <div class="srs-content"> <div class="srs-c-inner"> <h4>Best of Both Worlds</h4> <p>NK cells are known for their powerful innate activity against tumors, but are short-lived. T cells, on the other hand, have durable persistence, up to years or decades. SynKIR™ combines the power of NK cell KIR receptors with the long-term durability of T cells, resulting in a long-lasting and powerful anti-cancer efficacy in mouse models.</p> </div> </div> <div class="srs-image"> <img src="https://verismotherapeutics.com/wp-content/uploads/2022/09/sci-dia-3.png"> </div> </div> </div> <div class="row"> </div> </div> </section> <section id="sci-r3" class="lightblue"> <div class="container"> <div class="row justify-content-center"> <div class="col-12 col-md-10 text-center"> <h2>The Past Paradigm of CAR T</h2> <p>A traditional CAR consists of multiple parts combined into a single (mono-chain) protein. Different parts are borrowed from other proteins that do not normally combine in the body. This multi-part recombined unit is called the chimeric receptor.</p> <div><img decoding="async" class="aligncenter size-full wp-image-255" src="https://verismotherapeutics.com/wp-content/uploads/2022/09/TIMELINE-graphicv2.png" alt="" width="2935" /></div> <p>A traditional CAR consists of a mono-chain protein, comprising an intracellular domain, a transmembrane domain, a spacer domain, and a targeting extracellular scFv portion. To date, seven CAR T therapies (all 2nd generation) have been approved using this mono-chain design, all for cancers originating from blood cells: Kymriah<sup>®</sup>, Yescarta<sup>®</sup>, Tecartus<sup>®</sup>, Breyanzi<sup>®</sup>, Abecma<sup>®</sup>, Carvykti<sup>®</sup>, and Carteyva<sup>®</sup>.</p> </div> </div> </div> </section> <section id="sci-r4" class=""> <div class="container"> <div class="row justify-content-center"> <div class="col-12 col-md-10 text-center"> <h2>The KIR-CAR Paradigm Shift of CAR T</h2> <p>Verismo Therapeutics’ scientific founders recognized that the classic mono-chain CAR design could be improved with a dual-chain coupling/decoupling design that acts as a natural on/off switch.</p> <p>Inspired by Natural Killer cell KIR receptors, the KIR-CAR platform provides a naturally evolved stimulation signal to T cells. This more natural signaling may increase T cells’ efficacy period by coupling the receptor chains for activation and decoupling them for rest, improving functional persistence and limiting exhaustion.<br /> <div class="d-none d-md-block"><br /> <img fetchpriority="high" decoding="async" class="aligncenter size-full wp-image-256" src="https://verismotherapeutics.com/wp-content/uploads/2022/09/sci-d-4.png" alt="" width="2234" height="1065" srcset="https://verismotherapeutics.com/wp-content/uploads/2022/09/sci-d-4.png 2234w, https://verismotherapeutics.com/wp-content/uploads/2022/09/sci-d-4-300x143.png 300w, https://verismotherapeutics.com/wp-content/uploads/2022/09/sci-d-4-1024x488.png 1024w, https://verismotherapeutics.com/wp-content/uploads/2022/09/sci-d-4-768x366.png 768w, https://verismotherapeutics.com/wp-content/uploads/2022/09/sci-d-4-1536x732.png 1536w, https://verismotherapeutics.com/wp-content/uploads/2022/09/sci-d-4-2048x976.png 2048w" sizes="(max-width: 2234px) 100vw, 2234px" /><br /> </div><br /> <div class="d-block d-md-none"><br /> <img decoding="async" class="aligncenter size-full wp-image-419" src="https://verismotherapeutics.com/wp-content/uploads/2022/11/science-kir-mobile.png" alt="" width="381" height="939" srcset="https://verismotherapeutics.com/wp-content/uploads/2022/11/science-kir-mobile.png 381w, https://verismotherapeutics.com/wp-content/uploads/2022/11/science-kir-mobile-122x300.png 122w" sizes="(max-width: 381px) 100vw, 381px" /><br /> </div></p> </div> </div> </div> </section> <section id="sci-r5" class="lightblue"> <div class="container"> <div class="row"> <div class="col-12 col-md-6"> <h2>The Future of SynKIR™</h2> <p>SynKIR™ is eliminating solid tumors in models where traditional CAR T have failed. 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