Search results for: Y. Landkocz

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Landkocz</title> <meta name="description" content="Search results for: Y. Landkocz"> <meta name="keywords" content="Y. Landkocz"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler ml-auto" type="button" data-toggle="collapse" data-target="#navbarMenu" aria-controls="navbarMenu" aria-expanded="false" aria-label="Toggle navigation"> <span class="navbar-toggler-icon"></span> </button> <div class="w-100"> <div class="d-none d-lg-flex flex-row-reverse"> <form method="get" action="https://waset.org/search" class="form-inline my-2 my-lg-0"> <input class="form-control mr-sm-2" type="search" placeholder="Search Conferences" value="Y. 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Landkocz"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 3</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: Y. Landkocz</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3</span> Toxicological Validation during the Development of New Catalytic Systems Using Air/Liquid Interface Cell Exposure</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=M.%20Al%20Zallouha">M. Al Zallouha</a>, <a href="https://publications.waset.org/abstracts/search?q=Y.%20Landkocz"> Y. Landkocz</a>, <a href="https://publications.waset.org/abstracts/search?q=J.%20Brunet"> J. Brunet</a>, <a href="https://publications.waset.org/abstracts/search?q=R.%20Cousin"> R. Cousin</a>, <a href="https://publications.waset.org/abstracts/search?q=J.%20M.%20Halket"> J. M. Halket</a>, <a href="https://publications.waset.org/abstracts/search?q=E.%20Genty"> E. Genty</a>, <a href="https://publications.waset.org/abstracts/search?q=P.%20J.%20Martin"> P. J. Martin</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Verdin"> A. Verdin</a>, <a href="https://publications.waset.org/abstracts/search?q=D.%20Courcot"> D. Courcot</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Siffert"> S. Siffert</a>, <a href="https://publications.waset.org/abstracts/search?q=P.%20Shirali"> P. Shirali</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Billet"> S. Billet</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Toluene is one of the most used Volatile Organic Compounds (VOCs) in the industry. Amongst VOCs, Benzene, Toluene, Ethylbenzene and Xylenes (BTEX) emitted into the atmosphere have a major and direct impact on human health. It is, therefore, necessary to minimize emissions directly at source. Catalytic oxidation is an industrial technique which provides remediation efficiency in the treatment of these organic compounds. However, during operation, the catalysts can release some compounds, called byproducts, more toxic than the original VOCs. The catalytic oxidation of a gas stream containing 1000ppm of toluene on Pd/伪-Al2O3 can release a few ppm of benzene, according to the operating temperature of the catalyst. The development of new catalysts must, therefore, include chemical and toxicological validation phases. In this project, A549 human lung cells were exposed in air/liquid interface (Vitrocell庐) to gas mixtures derived from the oxidation of toluene with a catalyst of Pd/伪-Al2O3. Both exposure concentrations (i.e. 10 and 100% of catalytic emission) resulted in increased gene expression of Xenobiotics Metabolising Enzymes (XME) (CYP2E1 CYP2S1, CYP1A1, CYP1B1, EPHX1, and NQO1). Some of these XMEs are known to be induced by polycyclic organic compounds conventionally not searched during the development of catalysts for VOCs degradation. The increase in gene expression suggests the presence of undetected compounds whose toxicity must be assessed before the adoption of new catalyst. This enhances the relevance of toxicological validation of such systems before scaling-up and marketing. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=BTEX%20toxicity" title="BTEX toxicity">BTEX toxicity</a>, <a href="https://publications.waset.org/abstracts/search?q=air%2Fliquid%20interface%20cell%20exposure" title=" air/liquid interface cell exposure"> air/liquid interface cell exposure</a>, <a href="https://publications.waset.org/abstracts/search?q=Vitrocell%C2%AE" title=" Vitrocell庐"> Vitrocell庐</a>, <a href="https://publications.waset.org/abstracts/search?q=catalytic%20oxidation" title=" catalytic oxidation"> catalytic oxidation</a> </p> <a href="https://publications.waset.org/abstracts/18384/toxicological-validation-during-the-development-of-new-catalytic-systems-using-airliquid-interface-cell-exposure" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/18384.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">411</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> Influence of Smoking on Fine And Ultrafine Air Pollution Pm in Their Pulmonary Genetic and Epigenetic Toxicity</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Y.%20Landkocz">Y. Landkocz</a>, <a href="https://publications.waset.org/abstracts/search?q=C.%20Lepers"> C. Lepers</a>, <a href="https://publications.waset.org/abstracts/search?q=P.J.%20Martin"> P.J. Martin</a>, <a href="https://publications.waset.org/abstracts/search?q=B.%20Foug%C3%A8re"> B. Foug猫re</a>, <a href="https://publications.waset.org/abstracts/search?q=F.%20Roy%20Saint-Georges.%20A.%20Verdin"> F. Roy Saint-Georges. A. Verdin</a>, <a href="https://publications.waset.org/abstracts/search?q=F.%20Cazier"> F. Cazier</a>, <a href="https://publications.waset.org/abstracts/search?q=F.%20Ledoux"> F. Ledoux</a>, <a href="https://publications.waset.org/abstracts/search?q=D.%20Courcot"> D. Courcot</a>, <a href="https://publications.waset.org/abstracts/search?q=F.%20Sichel"> F. Sichel</a>, <a href="https://publications.waset.org/abstracts/search?q=P.%20Gosset"> P. Gosset</a>, <a href="https://publications.waset.org/abstracts/search?q=P.%20Shirali"> P. Shirali</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Billet"> S. Billet</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In 2013, the International Agency for Research on Cancer (IARC) classified air pollution and fine particles as carcinogenic to humans. Causal relationships exist between elevated ambient levels of airborne particles and increase of mortality and morbidity including pulmonary diseases, like lung cancer. However, due to a double complexity of both physicochemical Particulate Matter (PM) properties and tumor mechanistic processes, mechanisms of action remain not fully elucidated. Furthermore, because of several common properties between air pollution PM and tobacco smoke, like the same route of exposure and chemical composition, potential mechanisms of synergy could exist. Therefore, smoking could be an aggravating factor of the particles toxicity. In order to identify some mechanisms of action of particles according to their size, two samples of PM were collected: PM0.03 2.5 and PM0.33 2.5 in the urban-industrial area of Dunkerque. The overall cytotoxicity of the fine particles was determined on human bronchial cells (BEAS-2B). Toxicological study focused then on the metabolic activation of the organic compounds coated onto PM and some genetic and epigenetic changes induced on a co-culture model of BEAS-2B and alveolar macrophages isolated from bronchoalveolar lavages performed in smokers and non-smokers. The results showed (i) the contribution of the ultrafine fraction of atmospheric particles to genotoxic (eg. DNA double-strand breaks) and epigenetic mechanisms (eg. promoter methylation) involved in tumor processes, and (ii) the influence of smoking on the cellular response. Three main conclusions can be discussed. First, our results showed the ability of the particles to induce deleterious effects potentially involved in the stages of initiation and promotion of carcinogenesis. The second conclusion is that smoking affects the nature of the induced genotoxic effects. Finally, the in vitro developed cell model, using bronchial epithelial cells and alveolar macrophages can take into account quite realistically, some of the existing cell interactions existing in the lung. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=air%20pollution" title="air pollution">air pollution</a>, <a href="https://publications.waset.org/abstracts/search?q=fine%20and%20ultrafine%20particles" title=" fine and ultrafine particles"> fine and ultrafine particles</a>, <a href="https://publications.waset.org/abstracts/search?q=genotoxic%20and%20epigenetic%20alterations" title=" genotoxic and epigenetic alterations"> genotoxic and epigenetic alterations</a>, <a href="https://publications.waset.org/abstracts/search?q=smoking" title=" smoking"> smoking</a> </p> <a href="https://publications.waset.org/abstracts/18385/influence-of-smoking-on-fine-and-ultrafine-air-pollution-pm-in-their-pulmonary-genetic-and-epigenetic-toxicity" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/18385.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">347</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Indirect Genotoxicity of Diesel Engine Emission: An in vivo Study Under Controlled Conditions</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Y.%20Landkocz">Y. Landkocz</a>, <a href="https://publications.waset.org/abstracts/search?q=P.%20Gosset"> P. Gosset</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20H%C3%A9liot"> A. H茅liot</a>, <a href="https://publications.waset.org/abstracts/search?q=C.%20Corbi%C3%A8re"> C. Corbi猫re</a>, <a href="https://publications.waset.org/abstracts/search?q=C.%20Vendeville"> C. Vendeville</a>, <a href="https://publications.waset.org/abstracts/search?q=V.%20Keravec"> V. Keravec</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Billet"> S. Billet</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Verdin"> A. Verdin</a>, <a href="https://publications.waset.org/abstracts/search?q=C.%20Monteil"> C. Monteil</a>, <a href="https://publications.waset.org/abstracts/search?q=D.%20Pr%C3%A9terre"> D. Pr茅terre</a>, <a href="https://publications.waset.org/abstracts/search?q=J-P.%20Morin"> J-P. Morin</a>, <a href="https://publications.waset.org/abstracts/search?q=F.%20Sichel"> F. Sichel</a>, <a href="https://publications.waset.org/abstracts/search?q=T.%20Douki"> T. Douki</a>, <a href="https://publications.waset.org/abstracts/search?q=P.%20J.%20Martin"> P. J. Martin</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Air Pollution produced by automobile traffic is one of the main sources of pollutants in urban atmosphere and is largely due to exhausts of the diesel engine powered vehicles. The International Agency for Research on Cancer, which is part of the World Health Organization, classified in 2012 diesel engine exhaust as carcinogenic to humans (Group 1), based on sufficient evidence that exposure is associated with an increased risk for lung cancer. Amongst the strategies aimed at limiting exhausts in order to take into consideration the health impact of automobile pollution, filtration of the emissions and use of biofuels are developed, but their toxicological impact is largely unknown. Diesel exhausts are indeed complex mixtures of toxic substances difficult to study from a toxicological point of view, due to both the necessary characterization of the pollutants, sampling difficulties, potential synergy between the compounds and the wide variety of biological effects. Here, we studied the potential indirect genotoxicity of emission of Diesel engines through on-line exposure of rats in inhalation chambers to a subchronic high but realistic dose. Following exposure to standard gasoil +/- rapeseed methyl ester either upstream or downstream of a particle filter or control treatment, rats have been sacrificed and their lungs collected. The following indirect genotoxic parameters have been measured: (i) telomerase activity and telomeres length associated with rTERT and rTERC gene expression by RT-qPCR on frozen lungs, (ii) 纬H2AX quantification, representing double-strand DNA breaks, by immunohistochemistry on formalin fixed-paraffin embedded (FFPE) lung samples. These preliminary results will be then associated with global cellular response analyzed by pan-genomic microarrays, monitoring of oxidative stress and the quantification of primary DNA lesions in order to identify biological markers associated with a potential pro-carcinogenic response of diesel or biodiesel, with or without filters, in a relevant system of in vivo exposition. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=diesel%20exhaust%20exposed%20rats" title="diesel exhaust exposed rats">diesel exhaust exposed rats</a>, <a href="https://publications.waset.org/abstracts/search?q=%CE%B3H2AX" title=" 纬H2AX"> 纬H2AX</a>, <a href="https://publications.waset.org/abstracts/search?q=indirect%20genotoxicity" title=" indirect genotoxicity"> indirect genotoxicity</a>, <a href="https://publications.waset.org/abstracts/search?q=lung%20carcinogenicity" title=" lung carcinogenicity"> lung carcinogenicity</a>, <a href="https://publications.waset.org/abstracts/search?q=telomerase%20activity" title=" telomerase activity"> telomerase activity</a>, <a href="https://publications.waset.org/abstracts/search?q=telomeres%20length" title=" telomeres length"> telomeres length</a> </p> <a href="https://publications.waset.org/abstracts/18346/indirect-genotoxicity-of-diesel-engine-emission-an-in-vivo-study-under-controlled-conditions" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/18346.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">390</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a 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Search results for: Y. Landkocz