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class="mw-page-title-main">Calcifediol</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Ir para um artigo noutra língua. Disponível em 19 línguas" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-19" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">19 línguas</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D9%83%D8%A7%D9%84%D8%B3%D9%8A%D9%81%D9%8A%D8%AF%D9%8A%D9%88%D9%84" title="كالسيفيديول — árabe" lang="ar" hreflang="ar" data-title="كالسيفيديول" data-language-autonym="العربية" data-language-local-name="árabe" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-azb mw-list-item"><a href="https://azb.wikipedia.org/wiki/%DA%A9%D9%84%D8%B3%DB%8C%D9%81%D8%AF%DB%8C%D9%88%D9%84" title="کلسیفدیول — South Azerbaijani" lang="azb" hreflang="azb" data-title="کلسیفدیول" data-language-autonym="تۆرکجه" data-language-local-name="South Azerbaijani" class="interlanguage-link-target"><span>تۆرکجه</span></a></li><li class="interlanguage-link interwiki-cy mw-list-item"><a href="https://cy.wikipedia.org/wiki/Calciffediol" title="Calciffediol — galês" lang="cy" hreflang="cy" data-title="Calciffediol" data-language-autonym="Cymraeg" data-language-local-name="galês" class="interlanguage-link-target"><span>Cymraeg</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Calcidiol" title="Calcidiol — alemão" lang="de" hreflang="de" data-title="Calcidiol" data-language-autonym="Deutsch" data-language-local-name="alemão" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Calcifediol" title="Calcifediol — inglês" lang="en" hreflang="en" data-title="Calcifediol" data-language-autonym="English" data-language-local-name="inglês" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Calcifediol" title="Calcifediol — espanhol" lang="es" hreflang="es" data-title="Calcifediol" data-language-autonym="Español" data-language-local-name="espanhol" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-eu mw-list-item"><a href="https://eu.wikipedia.org/wiki/Kaltzifediol" title="Kaltzifediol — basco" lang="eu" hreflang="eu" data-title="Kaltzifediol" data-language-autonym="Euskara" data-language-local-name="basco" class="interlanguage-link-target"><span>Euskara</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%DA%A9%D9%84%D8%B3%DB%8C%D9%81%D8%AF%DB%8C%D9%88%D9%84" title="کلسیفدیول — persa" lang="fa" hreflang="fa" data-title="کلسیفدیول" data-language-autonym="فارسی" data-language-local-name="persa" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Kalsidioli" title="Kalsidioli — finlandês" lang="fi" hreflang="fi" data-title="Kalsidioli" data-language-autonym="Suomi" data-language-local-name="finlandês" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Calcif%C3%A9diol" title="Calcifédiol — francês" lang="fr" hreflang="fr" data-title="Calcifédiol" data-language-autonym="Français" data-language-local-name="francês" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/Calcifediol" title="Calcifediol — galego" lang="gl" hreflang="gl" data-title="Calcifediol" data-language-autonym="Galego" data-language-local-name="galego" class="interlanguage-link-target"><span>Galego</span></a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Kalsifediol" title="Kalsifediol — indonésio" lang="id" hreflang="id" data-title="Kalsifediol" data-language-autonym="Bahasa Indonesia" data-language-local-name="indonésio" class="interlanguage-link-target"><span>Bahasa Indonesia</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Calcidiolo" title="Calcidiolo — italiano" lang="it" hreflang="it" data-title="Calcidiolo" data-language-autonym="Italiano" data-language-local-name="italiano" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%82%AB%E3%83%AB%E3%82%B7%E3%83%95%E3%82%A7%E3%82%B8%E3%82%AA%E3%83%BC%E3%83%AB" title="カルシフェジオール — japonês" lang="ja" hreflang="ja" data-title="カルシフェジオール" data-language-autonym="日本語" data-language-local-name="japonês" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Calcidiol" title="Calcidiol — neerlandês" lang="nl" hreflang="nl" data-title="Calcidiol" data-language-autonym="Nederlands" data-language-local-name="neerlandês" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Kalcyfediol" title="Kalcyfediol — polaco" lang="pl" hreflang="pl" data-title="Kalcyfediol" data-language-autonym="Polski" data-language-local-name="polaco" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/Calcifediol" title="Calcifediol — romeno" lang="ro" hreflang="ro" data-title="Calcifediol" data-language-autonym="Română" data-language-local-name="romeno" class="interlanguage-link-target"><span>Română</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Kalcifediol" title="Kalcifediol — servo-croata" lang="sh" hreflang="sh" data-title="Kalcifediol" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="servo-croata" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Kalcifediol" title="Kalcifediol — sérvio" lang="sr" hreflang="sr" data-title="Kalcifediol" data-language-autonym="Српски / srpski" data-language-local-name="sérvio" class="interlanguage-link-target"><span>Српски / srpski</span></a></li> </ul> <div 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href="/wiki/Especial:P%C3%A1ginas_afluentes/Calcifediol" title="Lista de todas as páginas que contêm hiperligações para esta [j]" accesskey="j"><span>Páginas afluentes</span></a></li><li id="t-recentchangeslinked" class="mw-list-item"><a href="/wiki/Especial:Altera%C3%A7%C3%B5es_relacionadas/Calcifediol" rel="nofollow" title="Mudanças recentes nas páginas para as quais esta contém hiperligações [k]" accesskey="k"><span>Alterações relacionadas</span></a></li><li id="t-upload" class="mw-list-item"><a href="/wiki/Wikipedia:Carregar_ficheiro" title="Carregar ficheiros [u]" accesskey="u"><span>Carregar ficheiro</span></a></li><li id="t-specialpages" class="mw-list-item"><a href="/wiki/Especial:P%C3%A1ginas_especiais" title="Lista de páginas especiais [q]" accesskey="q"><span>Páginas especiais</span></a></li><li id="t-permalink" class="mw-list-item"><a href="/w/index.php?title=Calcifediol&oldid=66181144" title="Hiperligação permanente para esta revisão desta página"><span>Hiperligação 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vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Aspeto</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">mover para a barra lateral</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">ocultar</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">Origem: Wikipédia, a enciclopédia livre.</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="pt" dir="ltr"><figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/Ficheiro:Calcidiol.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/9/98/Calcidiol.png/220px-Calcidiol.png" decoding="async" width="220" height="175" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/98/Calcidiol.png/330px-Calcidiol.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/98/Calcidiol.png/440px-Calcidiol.png 2x" data-file-width="1473" data-file-height="1175" /></a><figcaption>Estrutura química do Calcidiol.</figcaption></figure> <p><span>O </span><b>Calcifediol</b> (<a href="/wiki/Denomina%C3%A7%C3%A3o_Comum_Internacional" title="Denominação Comum Internacional">INN</a>), também conhecido como <b>calcidiol</b>, <b>25-hidróxi-colecalciferol</b>, ou <b>25-hidróxi-vitamina D</b> (abreviado como <b>25(OH)D</b>),<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span>[</span>1<span>]</span></a></sup> é um <a href="/w/index.php?title=Prehormone&action=edit&redlink=1" class="new" title="Prehormone (página não existe)">pré-hormônio</a> que é produzido no <a href="/wiki/F%C3%ADgado" title="Fígado">fígado</a> através da <a href="/wiki/Hidroxialquila%C3%A7%C3%A3o" title="Hidroxialquilação">hidroxilação</a> da <a href="/wiki/Colecalciferol" title="Colecalciferol">vitamina D<sub>3</sub></a> (colecalciferol) através da enzima <a href="/w/index.php?title=Cholecalciferol_25-hydroxylase&action=edit&redlink=1" class="new" title="Cholecalciferol 25-hydroxylase (página não existe)">colecalciferol 25-hidroxilase</a>, isolada pela primeira vez por <a href="/wiki/Michael_F._Holick" title="Michael F. Holick">Michael F. Holick</a>. Esse metabólito é utilizado para avaliar o estado de vitamina D de um paciente.<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span>[</span>2<span>]</span></a></sup> O calcifediol é convertido então no rim (pela <a href="/wiki/Enzima" title="Enzima">enzima</a> <a href="/w/index.php?title=25-Hydroxyvitamin_D3_1-alpha-hydroxylase&action=edit&redlink=1" class="new" title="25-Hydroxyvitamin D3 1-alpha-hydroxylase (página não existe)">25(OH)D-1α-hidroxilase</a>) em <a href="/wiki/Calcitriol" title="Calcitriol">calcitriol</a> (1,25-(OH)<sub>2</sub>D<sub>3</sub>), um <a href="/wiki/Hormona" title="Hormona">hormônio</a> que é a forma ativa de vitamina D. Ele também pode ser convertido na forma inativa <a href="/w/index.php?title=24-hydroxycalcidiol&action=edit&redlink=1" class="new" title="24-hydroxycalcidiol (página não existe)">24-hidróxi-calcidiol</a> nos rins via 24-hidroxilação.</p><div><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span>[</span>3<span>]</span></a></sup><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span>[</span>4<span>]</span></a></sup></div> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Teste_de_sangue">Teste de sangue</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Calcifediol&veaction=edit&section=1" title="Editar secção: Teste de sangue" class="mw-editsection-visualeditor"><span>editar</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Calcifediol&action=edit&section=1" title="Editar código-fonte da secção: Teste de sangue"><span>editar código-fonte</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>O teste sanguíneo de 25-hidróxi-vitamina D (calcidiol) é usado clinicamente para aferir o conteúdo de vitamina D no corpo.<sup id="cite_ref-MedlinePlus_5-0" class="reference"><a href="#cite_note-MedlinePlus-5"><span>[</span>5<span>]</span></a></sup> A concentração de calcidiol no sangue é considerado o melhor indicador do seu <i>status</i> de vitamina.<sup id="cite_ref-heaney_6-0" class="reference"><a href="#cite_note-heaney-6"><span>[</span>6<span>]</span></a></sup> </p><p>Esse teste pode ser usado para diagnóstico de deficiência de vitamina D e determinar a melhor terapia.<sup id="cite_ref-ASCPfive_7-0" class="reference"><a href="#cite_note-ASCPfive-7"><span>[</span>7<span>]</span></a></sup> Pacientes com <a href="/wiki/Osteoporose" title="Osteoporose">osteoporose</a>, <a href="/wiki/Doen%C3%A7a_renal_cr%C3%B4nica" title="Doença renal crônica">doença renal crônico</a>, <a href="/wiki/M%C3%A1-absor%C3%A7%C3%A3o_intestinal" title="Má-absorção intestinal">malabsorção</a>, <a href="/wiki/Obesidade" title="Obesidade">obesidade</a>, e outras mais podem estar em situação de grande risco, sendo então indicados para fazer esse teste.<sup id="cite_ref-ASCPfive_7-1" class="reference"><a href="#cite_note-ASCPfive-7"><span>[</span>7<span>]</span></a></sup> Apesar da deficiência de vitamina D ser comum em algumas populações, incluindo algumas em altas latitudes e pouca exposição ao sol, o teste de 25(OH)D não é indicado para toda a população.<sup id="cite_ref-ASCPfive_7-2" class="reference"><a href="#cite_note-ASCPfive-7"><span>[</span>7<span>]</span></a></sup> </p><p> É a medida mais <a href="/wiki/Sensibilidade_(epidemiologia)" title="Sensibilidade (epidemiologia)">sensível</a>,<sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span>[</span>8<span>]</span></a></sup>  apesar de experts clamarem por maior padronização e reproducibilidade entre diferentes laboratórios.<sup id="cite_ref-heaney_6-1" class="reference"><a href="#cite_note-heaney-6"><span>[</span>6<span>]</span></a></sup> De acordo com <a href="/wiki/MedlinePlus" title="MedlinePlus">MedlinePlus</a>, a faixa normal de calcidiol é de 30.0 a 74.0 ng/mL.<sup id="cite_ref-MedlinePlus_5-1" class="reference"><a href="#cite_note-MedlinePlus-5"><span>[</span>5<span>]</span></a></sup> A faixa normal varia amplamente dependendo de diversos fatores, como idade e localização geográfica. <span style="background-color: rgba(254, 252, 224, 0.956863);">Uma</span> <a href="/w/index.php?title=Reference_ranges_for_blood_tests&action=edit&redlink=1" class="new" title="Reference ranges for blood tests (página não existe)">faixa de referência</a> de 20–150 nmol/L (8-60 ng/ml) também já foi sugerida,<sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span>[</span>9<span>]</span></a></sup> enquanto outros estudos apontam níveis abaixo de 80 nmol/L (32 ng/ml) como indicativos de deficiência de vitamina D.<sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span>[</span>10<span>]</span></a></sup> </p><p>Nos EUA, os níveis de 25(OH)D são relatados como ng/mL. Em outros países, é comum o uso de nmol/L. Multiplique ng/mL por 2.5 para a conversão aproximada em nmol/L. </p> <div class="mw-heading mw-heading3"><h3 id="Significado_clínico"><span id="Significado_cl.C3.ADnico"></span>Significado clínico</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Calcifediol&veaction=edit&section=2" title="Editar secção: Significado clínico" class="mw-editsection-visualeditor"><span>editar</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Calcifediol&action=edit&section=2" title="Editar código-fonte da secção: Significado clínico"><span>editar código-fonte</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>O aumendo de níveis de calcidiol é associado ao aumento da absorção fracional de cálcio do trato gastrontestinal até níveis de 80 nmol/L (32 ng/mL).<sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/w/index.php?title=Wikip%C3%A9dia:Citation_needed&action=edit&redlink=1" class="new" title="Wikipédia:Citation needed (página não existe)"><span title="This claim needs references to reliable sources. (December 2008)">citation needed</span></a></i>]</sup> A excreção de cálcio urinária balanceia a absorção intestinal, com níveis de calcidiol até ~400 nmol/L (160 ng/mL).<sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span>[</span>11<span>]</span></a></sup> </p><p>Um estudo de Cedric F. Garland e <a href="/w/index.php?title=Frank_C._Garland&action=edit&redlink=1" class="new" title="Frank C. Garland (página não existe)">Frank C. </a><a href="/w/index.php?title=Frank_C._Garland&action=edit&redlink=1" class="new" title="Frank C. Garland (página não existe)">Garland</a> da <a href="/wiki/Universidade_da_Calif%C3%B3rnia_em_San_Diego" title="Universidade da Califórnia em San Diego">University of California, San Diego</a> analisou o sangue de 25,000 voluntários do <a href="/wiki/Condado_de_Washington_(Maryland)" title="Condado de Washington (Maryland)">Condado de Washington, Maryland</a>, achando que altos níveis de calcifediol estavam relacionados com um risco de <a href="/wiki/C%C3%A2ncer_colorretal" title="Câncer colorretal">câncer de colo</a> de 1/5 em relação à taxa típica.<sup id="cite_ref-12" class="reference"><a href="#cite_note-12"><span>[</span>12<span>]</span></a></sup> Contudo, estudos randomizados controlados falharam na detecção de correlações significativas entre suplementação de vitamina D e o risco de câncer de cólon.<sup id="cite_ref-13" class="reference"><a href="#cite_note-13"><span>[</span>13<span>]</span></a></sup> </p><p>Em 2012 um <a href="/w/index.php?title=Registry_study&action=edit&redlink=1" class="new" title="Registry study (página não existe)">estudo de registro</a> ("<i>registry study</i>") da população de <a href="/wiki/Copenhaga" title="Copenhaga">Copenhagen</a>, <a href="/wiki/Dinamarca" title="Dinamarca">Dinamarca</a> encontrou uma correlação de níveis tanto alto quanto baixo dos níveis no soro e aumento de mortalidade, com um nível de  50–60 nmol/L sendo associado com a mortalidade mais baixo. O estudo <a href="/wiki/Cum_hoc_ergo_propter_hoc" class="mw-redirect" title="Cum hoc ergo propter hoc">não mostrou relação de causa</a>.<sup id="cite_ref-14" class="reference"><a href="#cite_note-14"><span>[</span>14<span>]</span></a></sup><sup id="cite_ref-15" class="reference"><a href="#cite_note-15"><span>[</span>15<span>]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Ver_também"><span id="Ver_tamb.C3.A9m"></span>Ver também</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Calcifediol&veaction=edit&section=3" title="Editar secção: Ver também" class="mw-editsection-visualeditor"><span>editar</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Calcifediol&action=edit&section=3" title="Editar código-fonte da secção: Ver também"><span>editar código-fonte</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Hipervitaminose_D" title="Hipervitaminose D">Hipervitaminose D</a></li> <li><a href="/wiki/Hypovitaminosis_D" class="mw-redirect" title="Hypovitaminosis D">Hipovitaminose D</a></li> <li><a href="/wiki/Vitamina_D" title="Vitamina D">Vitamin D</a></li> <li><a href="/wiki/Vitamina_D" title="Vitamina D">Health effects</a> of Vitamin D</li></ul> <h2 id="Referências" style="cursor: help;" title="Esta seção foi configurada para não ser editável diretamente. Edite a página toda ou a seção anterior em vez disso."><span id="Refer.C3.AAncias"></span>Referências</h2> <div class="reflist" style="list-style-type: decimal;"><div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink"><a href="#cite_ref-1">↑</a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://www.chem.qmul.ac.uk/iupac/misc/D.html">"Nomenclature of Vitamin D. </a></span> </li> <li id="cite_note-2"><span class="mw-cite-backlink"><a href="#cite_ref-2">↑</a></span> <span class="reference-text"><cite class="citation journal">Holick, MF; Deluca, HF; Avioli, LV (1972). «Isolation and identification of 25-hydroxycholecalciferol from human plasma». <i>Archives of Internal Medicine</i>. <b>129</b> (1): 56–61. <a href="/wiki/PubMed_Identifier" class="mw-redirect" title="PubMed Identifier">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/4332591">4332591</a>. <a href="/wiki/Digital_object_identifier" title="Digital object identifier">doi</a>:<a rel="nofollow" class="external text" href="https://dx.doi.org/10.1001%2Farchinte.1972.00320010060005">10.1001/archinte.1972.00320010060005</a></cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fpt.wikipedia.org%3ACalcifediol&rft.atitle=Isolation+and+identification+of+25-hydroxycholecalciferol+from+human+plasma&rft.au=Avioli%2C+LV&rft.au=Deluca%2C+HF&rft.aufirst=MF&rft.aulast=Holick&rft.date=1972&rft.genre=article&rft.issue=1&rft.jtitle=Archives+of+Internal+Medicine&rft.pages=56-61&rft.volume=129&rft_id=info%3Adoi%2F10.1001%2Farchinte.1972.00320010060005&rft_id=info%3Apmid%2F4332591&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal" class="Z3988"><span style="display:none;"> </span></span></span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><a href="#cite_ref-3">↑</a></span> <span class="reference-text"><cite class="citation book">Bender, David A.; Mayes, Peter A (2006). «Micronutrients: Vitamins & Minerals». In: Victor W. Rodwell; Murray, Robert F.; Harper, Harold W.; Granner, Darryl K.; Mayes, Peter A. <a rel="nofollow" class="external text" href="http://books.google.com.br/books?id=QrJCZ1v5T6AC"><i>Harper's Illustrated Biochemistry</i></a>. New York: Lange/McGraw-Hill. pp. 492–3. <a href="/wiki/International_Standard_Book_Number" title="International Standard Book Number">ISBN</a> <a href="/wiki/Especial:Fontes_de_livros/0-07-146197-3" title="Especial:Fontes de livros/0-07-146197-3">0-07-146197-3</a></cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fpt.wikipedia.org%3ACalcifediol&rft.atitle=Micronutrients%3A+Vitamins+%26+Minerals&rft.au=Mayes%2C+Peter+A&rft.aufirst=David+A.&rft.aulast=Bender&rft.btitle=Harper%27s+Illustrated+Biochemistry&rft.date=2006&rft.genre=bookitem&rft.isbn=0-07-146197-3&rft.pages=492-3&rft.place=New+York&rft.pub=Lange%2FMcGraw-Hill&rft_id=http%3A%2F%2Fbooks.google.com.br%2Fbooks%3Fid%3DQrJCZ1v5T6AC&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook" class="Z3988"><span style="display:none;"> </span></span><span class="citation-comment" style="display:none; color:#33aa33"> !CS1 manut: Usa parâmetro editores (<a href="/wiki/Categoria:!CS1_manut:_Usa_par%C3%A2metro_editores" title="Categoria:!CS1 manut: Usa parâmetro editores">link</a>)</span></span> </li> <li id="cite_note-4"><span class="mw-cite-backlink"><a href="#cite_ref-4">↑</a></span> <span class="reference-text"><cite class="citation book"><a href="/w/index.php?title=Institute_of_Medicine&action=edit&redlink=1" class="new" title="Institute of Medicine (página não existe)">Institute of Medicine</a> (1997). <a rel="nofollow" class="external text" href="http://www.nap.edu/openbook.php?record_id=5776&page=250">«Vitamin D»</a>. <a rel="nofollow" class="external text" href="http://www.nap.edu/catalog.php?record_id=5776"><i>Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride</i></a>. Washington, D.C: National Academy Press. 254 páginas. <a href="/wiki/International_Standard_Book_Number" title="International Standard Book Number">ISBN</a> <a href="/wiki/Especial:Fontes_de_livros/0-309-06403-1" title="Especial:Fontes de livros/0-309-06403-1">0-309-06403-1</a></cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fpt.wikipedia.org%3ACalcifediol&rft.atitle=Vitamin+D&rft.au=Institute+of+Medicine&rft.btitle=Dietary+Reference+Intakes+for+Calcium%2C+Phosphorus%2C+Magnesium%2C+Vitamin+D%2C+and+Fluoride&rft.date=1997&rft.genre=bookitem&rft.isbn=0-309-06403-1&rft.place=Washington%2C+D.C&rft.pub=National+Academy+Press&rft_id=http%3A%2F%2Fwww.nap.edu%2Fopenbook.php%3Frecord_id%3D5776%26page%3D250&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook" class="Z3988"><span style="display:none;"> </span></span></span> </li> <li id="cite_note-MedlinePlus-5"><span class="mw-cite-backlink">↑ <sup><i><b><a href="#cite_ref-MedlinePlus_5-0">a</a></b></i></sup> <sup><i><b><a href="#cite_ref-MedlinePlus_5-1">b</a></b></i></sup></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://www.nlm.nih.gov/medlineplus/ency/article/003569.htm">"25-hydroxy vitamin D test: Medline Plus"</a>. </span> </li> <li id="cite_note-heaney-6"><span class="mw-cite-backlink">↑ <sup><i><b><a href="#cite_ref-heaney_6-0">a</a></b></i></sup> <sup><i><b><a href="#cite_ref-heaney_6-1">b</a></b></i></sup></span> <span class="reference-text"><cite class="citation journal">Heaney, Robert P (dezembro de 2004). <a rel="nofollow" class="external text" href="http://www.ajcn.org/cgi/content/full/80/6/1706S">«Functional indices of vitamin D status and ramifications of vitamin D deficiency»</a>. <i>American Journal of Clinical Nutrition</i>. <b>80</b> (6): 1706S–9S. <a href="/wiki/PubMed_Identifier" class="mw-redirect" title="PubMed Identifier">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/15585791">15585791</a></cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fpt.wikipedia.org%3ACalcifediol&rft.atitle=Functional+indices+of+vitamin+D+status+and+ramifications+of+vitamin+D+deficiency&rft.aufirst=Robert+P&rft.aulast=Heaney&rft.date=2004-12&rft.genre=article&rft.issue=6&rft.jtitle=American+Journal+of+Clinical+Nutrition&rft.pages=1706S-9S&rft.volume=80&rft_id=http%3A%2F%2Fwww.ajcn.org%2Fcgi%2Fcontent%2Ffull%2F80%2F6%2F1706S&rft_id=info%3Apmid%2F15585791&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal" class="Z3988"><span style="display:none;"> </span></span></span> </li> <li id="cite_note-ASCPfive-7"><span class="mw-cite-backlink">↑ <sup><i><b><a href="#cite_ref-ASCPfive_7-0">a</a></b></i></sup> <sup><i><b><a href="#cite_ref-ASCPfive_7-1">b</a></b></i></sup> <sup><i><b><a href="#cite_ref-ASCPfive_7-2">c</a></b></i></sup></span> <span class="reference-text"><cite id="CITEREFAmerican_Society_for_Clinical_Pathology" class="citation"><a href="/w/index.php?title=American_Society_for_Clinical_Pathology&action=edit&redlink=1" class="new" title="American Society for Clinical Pathology (página não existe)">American Society for Clinical Pathology</a>, <a rel="nofollow" class="external text" href="http://www.choosingwisely.org/doctor-patient-lists/american-society-for-clinical-pathology/">«Five Things Physicians and Patients Should Question»</a>, American Society for Clinical Pathology, <i><a href="/w/index.php?title=Choosing_Wisely&action=edit&redlink=1" class="new" title="Choosing Wisely (página não existe)">Choosing Wisely</a>: an initiative of the <a href="/w/index.php?title=ABIM_Foundation&action=edit&redlink=1" class="new" title="ABIM Foundation (página não existe)">ABIM Foundation</a></i><span class="reference-accessdate">, consultado em 1 de agosto de 2013</span></cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fpt.wikipedia.org%3ACalcifediol&rft.atitle=Five+Things+Physicians+and+Patients+Should+Question&rft.au=American+Society+for+Clinical+Pathology&rft.genre=article&rft.jtitle=Choosing+Wisely%3A+an+initiative+of+the+ABIM+Foundation&rft_id=http%3A%2F%2Fwww.choosingwisely.org%2Fdoctor-patient-lists%2Famerican-society-for-clinical-pathology%2F&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal" class="Z3988"><span style="display:none;"> </span></span>, which cites</span> </li> <li id="cite_note-8"><span class="mw-cite-backlink"><a href="#cite_ref-8">↑</a></span> <span class="reference-text">Institute of Medicine (1997), p. 259</span> </li> <li id="cite_note-9"><span class="mw-cite-backlink"><a href="#cite_ref-9">↑</a></span> <span class="reference-text"><cite class="citation book">Bender, David A. (2003). «Vitamin D». <a rel="nofollow" class="external text" href="http://books.google.com.br/books?id=pxEJNs0IUo4C"><i>Nutritional biochemistry of the vitamins</i></a>. Cambridge: Cambridge University Press. <a href="/wiki/International_Standard_Book_Number" title="International Standard Book Number">ISBN</a> <a href="/wiki/Especial:Fontes_de_livros/0-521-80388-8" title="Especial:Fontes de livros/0-521-80388-8">0-521-80388-8</a></cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fpt.wikipedia.org%3ACalcifediol&rft.atitle=Vitamin+D&rft.au=Bender%2C+David+A.&rft.btitle=Nutritional+biochemistry+of+the+vitamins&rft.date=2003&rft.genre=bookitem&rft.isbn=0-521-80388-8&rft.place=Cambridge&rft.pub=Cambridge+University+Press&rft_id=http%3A%2F%2Fbooks.google.com.br%2Fbooks%3Fid%3DpxEJNs0IUo4C&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook" class="Z3988"><span style="display:none;"> </span></span></span> </li> <li id="cite_note-10"><span class="mw-cite-backlink"><a href="#cite_ref-10">↑</a></span> <span class="reference-text"><cite class="citation journal">Hollis BW (fevereiro de 2005). <a rel="nofollow" class="external text" href="http://jn.nutrition.org/cgi/pmidlookup?view=long&pmid=15671234">«Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a new effective dietary intake recommendation for vitamin D»</a>. <i>J Nutr</i>. <b>135</b> (2): 317–22. <a href="/wiki/PubMed_Identifier" class="mw-redirect" title="PubMed Identifier">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/15671234">15671234</a></cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fpt.wikipedia.org%3ACalcifediol&rft.atitle=Circulating+25-hydroxyvitamin+D+levels+indicative+of+vitamin+D+sufficiency%3A+implications+for+establishing+a+new+effective+dietary+intake+recommendation+for+vitamin+D&rft.au=Hollis+BW&rft.date=2005-02&rft.genre=article&rft.issue=2&rft.jtitle=J+Nutr&rft.pages=317-22&rft.volume=135&rft_id=http%3A%2F%2Fjn.nutrition.org%2Fcgi%2Fpmidlookup%3Fview%3Dlong%26pmid%3D15671234&rft_id=info%3Apmid%2F15671234&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal" class="Z3988"><span style="display:none;"> </span></span></span> </li> <li id="cite_note-11"><span class="mw-cite-backlink"><a href="#cite_ref-11">↑</a></span> <span class="reference-text"><cite class="citation journal">Kimball; et al. (2004). «Safety of vitamin D3 in adults with multiple sclerosis». <i>J Clin Endocrinol Metab</i>. <b>86</b> (3): 645–51. <a href="/wiki/PubMed_Identifier" class="mw-redirect" title="PubMed Identifier">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/17823429">17823429</a></cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fpt.wikipedia.org%3ACalcifediol&rft.atitle=Safety+of+vitamin+D3+in+adults+with+multiple+sclerosis&rft.au=Kimball&rft.au=O%27Connor%2C+P&rft.au=Ursell%2C+MR&rft.au=Vieth%2C+R&rft.date=2004&rft.genre=article&rft.issue=3&rft.jtitle=J+Clin+Endocrinol+Metab&rft.pages=645-51&rft.volume=86&rft_id=info%3Apmid%2F17823429&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal" class="Z3988"><span style="display:none;"> </span></span></span> </li> <li id="cite_note-12"><span class="mw-cite-backlink"><a href="#cite_ref-12">↑</a></span> <span class="reference-text">Maugh II, Thomas H. </span> </li> <li id="cite_note-13"><span class="mw-cite-backlink"><a href="#cite_ref-13">↑</a></span> <span class="reference-text"><cite class="citation journal">Wactawski-Wende, J; Kotchen, JM, Women's Health Initiative Investigators (9 de março de 2006). <a rel="nofollow" class="external text" href="http://www.nejm.org/doi/full/10.1056/NEJMoa055222">«Calcium plus vitamin D supplementation and the risk of colorectal cancer.»</a>. <i>N Engl J Med</i>. <b>954</b> (10). 1102 páginas. <a href="/wiki/PubMed_Identifier" class="mw-redirect" title="PubMed Identifier">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/16481636">16481636</a>. <a href="/wiki/Digital_object_identifier" title="Digital object identifier">doi</a>:<a rel="nofollow" class="external text" href="https://dx.doi.org/10.1056%2FNEJMoa055222">10.1056/NEJMoa055222</a><span class="reference-accessdate">. Consultado em 28 de dezembro de 2013</span></cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fpt.wikipedia.org%3ACalcifediol&rft.atitle=Calcium+plus+vitamin+D+supplementation+and+the+risk+of+colorectal+cancer.&rft.au=Kotchen%2C+JM%2C+Women%27s+Health+Initiative+Investigators&rft.aufirst=J&rft.aulast=Wactawski-Wende&rft.date=2006-03-09&rft.genre=article&rft.issue=10&rft.jtitle=N+Engl+J+Med&rft.volume=954&rft_id=http%3A%2F%2Fwww.nejm.org%2Fdoi%2Ffull%2F10.1056%2FNEJMoa055222&rft_id=info%3Adoi%2F10.1056%2FNEJMoa055222&rft_id=info%3Apmid%2F16481636&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal" class="Z3988"><span style="display:none;"> </span></span></span> </li> <li id="cite_note-14"><span class="mw-cite-backlink"><a href="#cite_ref-14">↑</a></span> <span class="reference-text"><cite class="citation pressrelease"><a rel="nofollow" class="external text" href="http://news.ku.dk/all_news/2012/2012.5/too_much_vitamin_d_can_be_as_unhealthy_as_too_little/">«Too much vitamin D can be as unhealthy as too little»</a> (Nota de imprensa). <a href="/w/index.php?title=University_of_Copenhagen&action=edit&redlink=1" class="new" title="University of Copenhagen (página não existe)">University of Copenhagen</a>. 29 de maio de 2012<span class="reference-accessdate">. Consultado em 27 de maio de 2015</span></cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fpt.wikipedia.org%3ACalcifediol&rft.btitle=Too+much+vitamin+D+can+be+as+unhealthy+as+too+little&rft.date=2012-05-29&rft.genre=unknown&rft.pub=University+of+Copenhagen&rft_id=http%3A%2F%2Fnews.ku.dk%2Fall_news%2F2012%2F2012.5%2Ftoo_much_vitamin_d_can_be_as_unhealthy_as_too_little%2F&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook" class="Z3988"><span style="display:none;"> </span></span></span> </li> <li id="cite_note-15"><span class="mw-cite-backlink"><a href="#cite_ref-15">↑</a></span> <span class="reference-text"><cite class="citation journal">Durup, D.; Jørgensen, H. L.; Christensen, J.; Schwarz, P.; Heegaard, A. M.; Lind, B. (9 de maio de 2012). <a rel="nofollow" class="external text" href="http://press.endocrine.org/doi/abs/10.1210/jc.2012-1176">«A Reverse J-Shaped Association of All-Cause Mortality with Serum 25-Hydroxyvitamin D in General Practice: The CopD Study»</a>. Endocrine Society. <i>The Journal of Clinical Endocrinology & Metabolism</i>. <b>97</b> (8): 2644–2652. <a href="/wiki/Digital_object_identifier" title="Digital object identifier">doi</a>:<a rel="nofollow" class="external text" href="https://dx.doi.org/10.1210%2Fjc.2012-1176">10.1210/jc.2012-1176</a><span class="reference-accessdate">. Consultado em 27 de maio de 2015</span></cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fpt.wikipedia.org%3ACalcifediol&rft.atitle=A+Reverse+J-Shaped+Association+of+All-Cause+Mortality+with+Serum+25-Hydroxyvitamin+D+in+General+Practice%3A+The+CopD+Study&rft.au=Christensen%2C+J.&rft.au=Heegaard%2C+A.+M.&rft.au=J%C3%B8rgensen%2C+H.+L.&rft.au=Lind%2C+B.&rft.au=Schwarz%2C+P.&rft.aufirst=D.&rft.aulast=Durup&rft.date=2012-05-09&rft.genre=article&rft.issue=8&rft.jtitle=The+Journal+of+Clinical+Endocrinology+%26+Metabolism&rft.pages=2644-2652&rft.volume=97&rft_id=http%3A%2F%2Fpress.endocrine.org%2Fdoi%2Fabs%2F10.1210%2Fjc.2012-1176&rft_id=info%3Adoi%2F10.1210%2Fjc.2012-1176&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal" class="Z3988"><span style="display:none;"> </span></span></span> </li> </ol></div></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?useformat=desktop&type=1x1&usesul3=0" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Obtida de "<a dir="ltr" href="https://pt.wikipedia.org/w/index.php?title=Calcifediol&oldid=66181144">https://pt.wikipedia.org/w/index.php?title=Calcifediol&oldid=66181144</a>"</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Especial:Categorias" title="Especial:Categorias">Categorias</a>: <ul><li><a href="/wiki/Categoria:Vitamina_D" title="Categoria:Vitamina D">Vitamina D</a></li><li><a href="/wiki/Categoria:Secosteroides" title="Categoria:Secosteroides">Secosteroides</a></li></ul></div><div id="mw-hidden-catlinks" class="mw-hidden-catlinks mw-hidden-cats-hidden">Categoria oculta: <ul><li><a href="/wiki/Categoria:!CS1_manut:_Usa_par%C3%A2metro_editores" title="Categoria:!CS1 manut: Usa parâmetro editores">!CS1 manut: Usa parâmetro editores</a></li></ul></div></div> </div> </main> </div> <div class="mw-footer-container"> <footer id="footer" class="mw-footer" > <ul id="footer-info"> <li id="footer-info-lastmod"> Esta página foi editada pela última vez às 04h15min de 2 de julho de 2023.</li> <li id="footer-info-copyright">Este texto é disponibilizado nos termos da licença <a rel="nofollow" class="external text" href="https://creativecommons.org/licenses/by-sa/4.0/deed.pt">Atribuição-CompartilhaIgual 4.0 Internacional (CC BY-SA 4.0) da Creative Commons</a>; pode estar sujeito a condições adicionais. 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