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Estimation of Enantioresolution of Multiple Stereogenic Drugs Using Mobilized and/or Immobilized Polysaccharide-Based HPLC Chiral Stationary Phases
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/></div></noscript> <!-- /Yandex.Metrika counter --> <!-- Matomo --> <!-- End Matomo Code --> <title>Estimation of Enantioresolution of Multiple Stereogenic Drugs Using Mobilized and/or Immobilized Polysaccharide-Based HPLC Chiral Stationary Phases</title> <meta name="description" content="Estimation of Enantioresolution of Multiple Stereogenic Drugs Using Mobilized and/or Immobilized Polysaccharide-Based HPLC Chiral Stationary Phases"> <meta name="keywords" content="HPLC, polysaccharide columns, enantio-resolution, indenolol, nadolol, labetalol"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link 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This study objectives to evaluate the efficiency of different mobilized and/or immobilized polysaccharide-based chiral stationary phases to separate enantiomers of some drugs containing multiple stereogenic centers namely indenolol, nadolol, labetalol. The critical mobile phase variables (composition of organic solvents, acid/base ratios) were carefully studied to compare the retention time and elution order of all isomers. Different chromatographic parameters such as capacity factor (k), selectivity (伪) and resolution (Rs) were calculated. Experimental conditions and the possible chiral recognition mechanisms have been discussed. <iframe src="https://publications.waset.org/abstracts/21594.pdf" style="width:100%; height:400px;" frameborder="0"></iframe> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=HPLC" title="HPLC">HPLC</a>, <a href="https://publications.waset.org/abstracts/search?q=polysaccharide%20columns" title=" polysaccharide columns"> polysaccharide columns</a>, <a href="https://publications.waset.org/abstracts/search?q=enantio-resolution" title=" enantio-resolution"> enantio-resolution</a>, <a href="https://publications.waset.org/abstracts/search?q=indenolol" title=" indenolol"> indenolol</a>, <a href="https://publications.waset.org/abstracts/search?q=nadolol" title=" nadolol"> nadolol</a>, <a href="https://publications.waset.org/abstracts/search?q=labetalol" title=" labetalol"> labetalol</a> </p> <a href="https://publications.waset.org/abstracts/21594/estimation-of-enantioresolution-of-multiple-stereogenic-drugs-using-mobilized-andor-immobilized-polysaccharide-based-hplc-chiral-stationary-phases" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/21594.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">450</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates 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