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class="block-views-blockheader"> <div class="view-content"> <div class="fixed-element field field--name-field-paragraph"> <div class="view-row"> <div class="paragraph-view-type-banner flex"> <div class="bgr-image-header"> <img src="https://www.reactionbiology.com/wp-content/uploads/2023/07/banner-FINAL-option-2.jpg" alt="CAR-T Cell Therapy Platform"> </div> <div class="container center"> <div class="field field--name-field-headline-big field--type-string field--label-hidden field__items"> <div class="field__item">Immuno-Oncology Platform</div> </div> </div> </div> </div> </div> </div> </div> </section> <div id="main-content"> <div id="block-proquinase-breadcrumbs" class="color-scheme-turquoise block block-system block-system-breadcrumb-block"> <div class="container"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <ol> <li><a href="https://www.reactionbiology.com">Home</a></li> <li>Services</li><li><a href="https://www.reactionbiology.com/services/immuno-oncology-platform/">Immuno-Oncology Platform</a></li><li><a href="https://www.reactionbiology.com/services/in-vivo-pharmacology/immuno-oncology-tumor-models/">Immuno-Oncology Tumor Models</a></li> <li>CAR-T Cell Therapy Platform</li> </ol> </nav> </div> </div> <div class="view-container view-simple-page-conent"> <div class="container"> <article id="post-8024" class="post-8024 page type-page status-publish hentry" itemtype="https://schema.org/CreativeWork" itemscope=""> <div class="entry-content entry-content-servises "> <h1>CAR T-Cell Therapy Platform</h1> <div class="text-mit-bild-text"> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__items"> <p>CAR T-cell therapy, especially when directed against CD19 for B cell cancers, has demonstrated remarkable efficacy and received <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996391/" rel="noopener" target="_blank">FDA approval</a> in 2017. Nonetheless, despite its achievements, there exist challenges that must be addressed for CAR T-cells to realize their complete therapeutic potential against both solid tumors and haematological malignancies. Reaction Biology stands at the forefront of preclinical cancer immunotherapy, providing a wide array of CAR T-cell development services. Our dedicated platform, crafted by our team of immuno-oncology specialists, employs a blend of <em>in vitro</em> and <em>in vivo</em> studies to accelerate your research endeavors.</p> <p>We offer a range of services, including: </p> <ul> <li>Evaluating the potency and pharmacokinetics of your CAR T candidate within <em>in vivo</em> models of cancer biology</li> <li>Assessing the <em>in vitro</em> cytotoxicity of your CAR T candidate across established cancer cell lines</li> <li>Delving into the activation and memory status of CAR T-cells to illuminate their therapeutic potential</li> <li>Testing the efficacy of CAR T candidates in xenograft models of solid tumors</li> </ul> <p>With our platform’s capabilities, we empower you to refine and advance your therapeutic strategies, driving forward progress in cancer immunotherapy.</p> </div> <div class="contact-buttons"> <div class="color-scheme-turquoise block block-block-content block-block-content9594f627-1f8b-4f13-b65e-979c19e399c0"> <a href="https://www.reactionbiology.com/contact/contact-us"> <div class="field field--name-field-icon field--type-image field--label-hidden field__items"> <img decoding="async" src="https://www.reactionbiology.com/wp-content/themes/Divi-child/images/icons-email.svg" alt="E-Mail" title="E-Mail" typeof="foaf:Image"> </div> <div class="field field--name-field-text field--type-string field--label-hidden field__items"> Contact an expert </div> </a> </div> <div class="color-scheme-turquoise block block-block-content block-block-contentc2ce2ae7-66e6-4f1b-87fb-ded5e6bcfb90"> <a class="newsletter-icon-box" href="#"> <div class="field field--name-field-icon field--type-image field--label-hidden field__items"> <img decoding="async" src="https://www.reactionbiology.com/wp-content/themes/Divi-child/images/icons-newsletter.svg" alt="Subscribe to Newsletter" title="Subscribe to Newsletter" typeof="foaf:Image"> </div> <div class="field field--name-field-text field--type-string field--label-hidden field__items"> Subscribe to our newsletter </div> </a> </div> <div class="color-scheme-turquoise block block-block-content block-block-content427638f8-6c52-46af-9064-2fe39ae6579d"> <a href="/#conferences"> <div class="field field--name-field-icon field--type-image field--label-hidden field__items"> <img decoding="async" src="https://www.reactionbiology.com/wp-content/themes/Divi-child/images/icons-meeting.svg" alt="Meet us at your next conference" title="Meet us at your next conference" typeof="foaf:Image"> </div> <div class="field field--name-field-text field--type-string field--label-hidden field__items"> Meet us at your next conference </div> </a> </div> <div class="color-scheme-turquoise block block-block-content block-block-contentff27f1d7-2f17-4dd2-ad72-3ef66b6982de"> <a href="/cdn-cgi/l/email-protection#bb84c8ced9d1ded8cf86f29bccdad5cf9bcfd49bc8d3dac9de9bcfd3d2c89be9dedad8cfd2d4d59bf9d2d4d7d4dcc29bd7d2d5d09bccd2cfd39bc2d4ce9ddad6cb80d9d4dfc286d3cfcfcbc8819494cccccc95c9dedad8cfd2d4d5d9d2d4d7d4dcc295d8d4d694c8dec9cdd2d8dec894d2d6d6ced5d496d4d5d8d4d7d4dcc296cbd7dacfddd4c9d694d8dac9cf96cfd3dec9dacbc296cbd7dacfddd4c9d6"> <div class="field field--name-field-icon field--type-image field--label-hidden field__items"> <img decoding="async" src="https://www.reactionbiology.com/wp-content/themes/Divi-child/images/icons-share.svg" alt="Share" title="Share" typeof="foaf:Image"> </div> <div class="field field--name-field-text field--type-string field--label-hidden field__items"> Share </div> </a> </div> </div> </div> </div> </article> </div> </div> <div id="teaser-boxes-5_anchor" class="paragraph weiss black paragraph--type--paragraph-container paragraph--view-mode--default"><div id="tcka-id" class="paragraph text-right images-1 headline-right contact-buttons- paragraph--type--text-with-image paragraph--view-mode--default"><div class="container center"><div class="text-wrapper"><h3>Strategies for successful <br />CAR T-cell therapy development</h3> <div class="text-mit-bild-text"> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__items"> <p>Barriers to effective CAR T-cell therapy encompass on-target off-tumor toxicities, limited anti-tumor activity across diverse tumor profiles, antigen escape, an immunosuppressive tumor microenvironment, and restricted trafficking and infiltration into tumors. Strategies to mitigate these challenges include: </p> <ul> <li>Employing assays to evaluate tumor-specific post-translational modifications for refined targeting. </li> <li>Assessing donor-to-donor heterogeneity in response to anti-tumor activity to optimize therapeutic efficacy. </li> <li>Utilizing dual or tandem CARs to target multiple antigens concurrently. </li> <li>Utilizing combination immunotherapy with CAR T-cells and checkpoint blockade, or engineering CAR T-cells to provide immunostimulatory signals. </li> <li>Engineering CAR T-cells to enhance penetration through tumor stroma, or modulating chemokine receptors on CAR T-cells to respond to tumor-derived chemokines.</li> </ul> </div> </div> <div class="text-mit-bild-bild field field--name-field-images field--type-image field--label-hidden field__items"> <div class="text-mit-bild-bild-rahmen"> <div class="field__item"><img decoding="async" src="https://www.reactionbiology.com/wp-content/uploads/2023/07/car-t-cell-therapy.png" alt="" width="750" /></div> </div> </div> </div></div></div><div id="tcka-id3" class="paragraph paragraph--type--tab-container paragraph--view-mode--default"><div class="container center"><h2>CAR T-cell therapy platform by Reaction Biology</h2> <div class="tab-container"><ul class="tab-navigation"><li class="tab-active" data-id="#tab-tcka-id321">Haematological malignancies</li><li data-id="#tab-tcka-id322">Solid tumor</li></ul><div class="field field--name-field-paragraph field--type-entity-reference-revisions field--label-hidden field__items"><div id="tab-tcka-id321" class="tab-content-active paragraph paragraph--type--tab-text-with-image paragraph--view-mode--default"><div class="field field--name-field-title field--type-string field--label-hidden field__items">Haematological malignancies</div><div class="tab-content"><div class="tab-content-wrapper"><div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__items"><p>Our robust CD19 CAR T cell assay suite is ideal for you to study the efficacy and pharmacokinetic properties by monitoring the anti-CD19 CAR T-cells in various preclinical <em>in vitro</em> and <em>in vivo</em> assay models.</p> <p><span style="font-size:16px;"><strong>Case I: Assess donor-to-donor variability of CD19 CAR T-cells in B cell leukemia model</strong></span></p> <p align="center"><img decoding="async" src="https://www.reactionbiology.com/wp-content/uploads/2023/07/case-1.jpg" width="900"></p> <p><span style="font-size:16px;"><strong>Case II: Measure <i>in vitro</i> cytotoxicity of CD19 CAR T-cells in NALM-6 and MOLM-13 cell lines</strong></span></p> <p align="center"><img decoding="async" src="https://www.reactionbiology.com/wp-content/uploads/2023/07/case-2.jpg" width="900"></p> <p><span style="font-size:16px;"><strong>Case III: Evaluate the activation and memory status of CD19 CAR T-cells via flow cytometry</strong></span></p> <p align="center"><img decoding="async" src="https://www.reactionbiology.com/wp-content/uploads/2023/07/case3.png" width="800"></p> </div></div></div></div><div id="tab-tcka-id322" class=" paragraph paragraph--type--tab-text-with-image paragraph--view-mode--default"><div class="field field--name-field-title field--type-string field--label-hidden field__items">Solid tumor</div><div class="tab-content"><div class="tab-content-wrapper"><div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__items"><p>Our scientists have rigorously optimized the development of various <em>in vivo</em> and <em>in vitro</em> service portfolio to evaluate novel CAR T-cells, with a specific focus on addressing the challenges associated with CAR T therapy for solid tumors.</p> <p><strong>Case IV: Anti-tumor activity of CAR T-cells in NSG mice engrafted with a subcutaneous THP-1 xenograft tumor model</strong></p> <p align="center"><img decoding="async" 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