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href="https://www.fps-pharma.com/category-product/micronizing-mills/spare-parts-for-micronization/">Spare parts</a></div></div></div></div></div></div></div><div class="container-fluid nopad"><div class="row"><div class="col-12 posrel"><div id="carouselPrincipale" class="carousel slide carousel-fade" data-bs-ride="carousel" data-bs-pause="false"><div class="carousel-inner"><div class="carousel-item active" style="background:transparent url(https://www.fps-pharma.com/wp-content/uploads/2022/07/fps-1130-5520-1.jpg) no-repeat center center;background-size:cover;"></div></div></div><div class="titolosucarousel"><div class="breadcrumbs"><ul id="breadcrumbs_list" class="breadcrumbs_list"><li class="item-parent item-parent-316"><a class="bread-parent bread-parent-316" href="https://www.fps-pharma.com/solutions/" title="Solutions">Solutions</a></li><li class="item-current item-318"><strong title="Fine Grinding聽and Micronization"> Fine Grinding聽and Micronization</strong></li></ul></div><h1>Fine Grinding聽and Micronization</h1></div></div></div></div><div class="pt-5 pb-5 mt-5 mb-5"><div class="container pt-5 pb-5 mt-5 mb-5"><div class="row"><div class="col-12"><div class="wp-block-columns is-layout-flex wp-container-core-columns-is-layout-1 wp-block-columns-is-layout-flex"><div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow"><figure class="wp-block-image size-large"><img decoding="async" src="https://www.fps-pharma.com/wp-content/uploads/2022/07/macinazione-setacciatura.jpg" alt=""/></figure></div><div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow"><h2 class="wp-block-heading">What is micronization?</h2><p>Micronization is the technique for <strong>reducing the particle size</strong> of an excipient鈥檚 active ingredient.</p><p>In the <a href="http://www.fps-pharma.com/sectors/pharmacheutical/">pharmaceutical field</a>, powders consist of a heterogeneous group of solid particles and can be considered the simplest pharmaceutical form as such and/or can be used to produce other formulations such as tablets, capsules, or suspensions.</p><p>Generally, the particles are heterogeneous, differing in shape, size, and surface area: hence, powders are a collection of solid, dry, separated particles of regular shape and varying in size from 0.5 to 1000 渭m and are the basis for the preparation of granules, tablets, and capsules.</p><p><strong>Fine grinding is the mechanical reduction of a coarse solid material into smaller particles.</strong> It is also known as “<strong>particle size reduction</strong>“.</p><h2 class="wp-block-heading">Particle size reduction</h2><p>Depending on the size of the starting material and the type of product obtained we have:</p><ul class="wp-block-list"><li>Crushing (50-10 mm)</li><li>Pulverization (or fine grinding) (down to 100 to 50 渭m)</li><li>Micronization (down to 1 渭m)</li></ul><p>Dedicated special equipment is available for each of these operations.</p><p>The <a href="http://www.fps-pharma.com/category-product/micronizing-mills/">reduction of particle size</a> below 100碌m, is a key process and requirement in laboratories and in small- and large-scale production. The benefits obtained from this operation are several: bioavailability, dispersion (aerosol) in pharmaceutical applications, dispersion, blending effect, adherence, long-lasting effect and silky touch for cosmetic applications, increased surface area for other applications.</p></div></div></div></div><div class="row"><div class="col-sm-12 col-md-10 offset-md-1"><div class="accordion" id="accordionExample"><div class="accordion-item"><h2 class="accordion-header" id="heading1"> <button class="accordion-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapse1" aria-expanded="true" aria-controls="collapse1"> What is micronization process? </button></h2><div id="collapse1" class="accordion-collapse collapse" aria-labelledby="heading1" data-bs-parent="#accordionExample"><div class="accordion-body"><p>Micronization process is the state-of-the-art technique for <strong>reducing the particle size</strong> of an excipient’s active ingredient. It is used to meet the particle size requirements of APIs and excipients, parameters that are very often critical to the formulation of the finished product and necessary for achieving the desired bioavailability of the product.</p><p>Micronization, which reduces particles down to the micrometer or, in some cases, nanometer (1/1000 of a micrometer) size, can be used to <strong>improve the bioavailability</strong> of poorly soluble APIs by increasing particle surface area and accelerating dissolution rates. Micronization can also be used to <strong>improve formulation homogeneity and control particle size</strong>. A wide range of drug types, including solid dosage, injectable, ocular, and inhaled products, can benefit from micronization.</p><p>Micronization is most often used to describe processes that reduce particle size by using fluid energy, such as a jet mill, rather than by mechanical means.</p><p>There are <strong>multiple advantages</strong> of using a jet mill to grind dry powders over other particle size reduction technologies.</p><p>Jet milling offers:</p><ul class="stileul"><li>High degree of material fineness</li><li>Low contamination due to absence of media, blades, knives, or screens</li><li>Internal classifier and good uniformity of size distribution</li><li>Low maintenance due to an absence of moving parts</li><li>Rapid disassembly of the system and ease of cleaning</li><li>Cryogenic application: possibility of working at low temperatures</li><li>Good productivity given by constant and continuous processing</li><li>No temperature rise in the mill due to expanding air creating a cooling effect, especially important for temperature sensitive materials, such as cosmetics</li></ul></div></div></div><div class="accordion-item"><h2 class="accordion-header" id="heading2"> <button class="accordion-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapse2" aria-expanded="true" aria-controls="collapse2"> How does the milling process take place? </button></h2><div id="collapse2" class="accordion-collapse collapse" aria-labelledby="heading2" data-bs-parent="#accordionExample"><div class="accordion-body"><p>Grinding is done by the application of a specific force and technique depending on the material that can deform individual particles until they are broken.</p><ul class="stileul"><li>Cutting for fibrous, naturally occurring materials</li><li>Compression for crystalline products</li><li>Impact (high-speed collisions) for friable materials</li><li>Friction (pressure-friction)</li></ul><p>The adoption of fluid jet mill technology is the “clean” alternative to mechanical milling and has several advantages:</p><ul class="stileul"><li>involves no moving mechanical parts and no friction,</li><li>it allows processing of heat-sensitive products,</li><li>assembly/disassembly is lighter</li><li>easier and faster cleaning.</li></ul><p>The pharmaceutical micronization process uses no mechanical parts, as the reduction of product particles occurs solely by impact between the fragments themselves, which are fed into the grinding chamber through a Venturi injector. The flow of gas (compressed air, nitrogen, argon or steam) is injected into the chamber through nozzles and favors dragging the particles into a vortex, which repeatedly collide with each other and progressively reduce their diameter and mass.</p><p>The material particles are dragged by the fluid at very high speed, and as they collide with each other, they undergo changes in speed and direction due to the shape of the chamber. In this way, the reduction of their size to values predefined by process operating conditions takes place.</p><p>In order to meet the particle size requirements of the APIs and/or excipients, which are necessary to meet the formulation parameters on the finished product, the selection of the various sizes of the micronized particles takes place through the presence of a “classifier” at the exit of the micronization chamber.</p></div></div></div><div class="accordion-item"><h2 class="accordion-header" id="heading3"> <button class="accordion-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapse3" aria-expanded="true" aria-controls="collapse3"> Which type of micronizer is the most suitable? </button></h2><div id="collapse3" class="accordion-collapse collapse" aria-labelledby="heading3" data-bs-parent="#accordionExample"><div class="accordion-body"><p>The choice of micronizer type depends on several variables, including:</p><ul class="stileul"><li>Type of material (hardness, hygroscopicity, particle size, melting point, flammability, elasticity, etc.).</li><li>Type of operation (desired size, cleanliness, sterility, versatility, space occupied, cost, etc.).</li><li>Safety level</li><li>Accessories</li></ul><p>Spiral jet mill technology is recommended for target particle size distribution below 30 碌m, while QMill technology or pin mill is suitable for PSD in the 30-100 碌m range.</p><p>FPS offers a full range of equipment that ensures complete and safe micronization of powders of all types of materials. Starting from the early stages of research and customer dialogue to the design and implementation of production facilities and complete after-sales support, FPS ensures the appropriate equipment for any batch size and at every step of development.</p></div></div></div></div></div></div></div></div><div class="container-fluid fpsgreen"><div class="row"><div class="col-12 col-sm-12 col-md-7 relatednews"> <span class="intestazionefascia ms-0 mb-5">Related products</span><div id="carouselCorrelate" class="carousel slide" data-bs-ride="carousel"><div class="carousel-inner"><div class="carousel-item active"> <a href="https://www.fps-pharma.com/category-product/micronizing-mills/spiral-jet-mill/" class="row posrel"><div class="col-3 col-sm-2"> <img src="https://www.fps-pharma.com/wp-content/uploads/2022/09/Spiral-jett-copertina.jpg" class="fullwidth"></div><div class="col-9 col-sm-10 spaziadess"> Spiral Jet Mill<p>With spiral jet mill technology, the size reduction is achieved by collisions between particles of the substance, previously accelerated by high-speed jet streams. Target PSD is generally below 30渭m when adopting this technology. Jet milling does not use mechanical components, but instead uses p [...]</p></div> <img src="https://www.fps-pharma.com/wp-content/themes/fps/img/ionic-ios-arrow-round-up.svg" class="svgfreccia" alt=""> </a> <a href="https://www.fps-pharma.com/category-product/micronizing-mills/qmill/" class="row posrel"><div class="col-3 col-sm-2"> <img src="https://www.fps-pharma.com/wp-content/uploads/2022/06/Immagine-47.png" class="fullwidth"></div><div class="col-9 col-sm-10 spaziadess"> Q-Mills<p>QMills technology: the alternative to mechanical mills. Oval chamber mills (Loop mills or Q-Mills) were introduced in 1941, and FPS launched its custom series in 2006. Interchangeable with spiral jet mills, QMill series is designed to be a pharmaceutical alternative to pin mills and hammer mills. [...]</p></div> <img src="https://www.fps-pharma.com/wp-content/themes/fps/img/ionic-ios-arrow-round-up.svg" class="svgfreccia" alt=""> </a></div><div class="carousel-item"> <a href="https://www.fps-pharma.com/category-product/micronizing-mills/multimilling-platform/" class="row posrel"><div class="col-3 col-sm-2"> <img src="https://www.fps-pharma.com/wp-content/uploads/2022/06/multimilling.jpg" class="fullwidth"></div><div class="col-9 col-sm-10 spaziadess"> Multimilling Platform<p>The multimilling station is the best choice for the execution of milling operations in research departments and pilot plants, with different technologies integrated on a single system. The platform considers: Spiral jet mill type PILOTMILL-4, PILOTMILL-5 or PILOTMILL-6 Pin mill 100 Loo [...]</p></div> <img src="https://www.fps-pharma.com/wp-content/themes/fps/img/ionic-ios-arrow-round-up.svg" class="svgfreccia" alt=""> </a> <a href="https://www.fps-pharma.com/category-product/micronizing-mills/mechanical-mills/" class="row posrel"><div class="col-3 col-sm-2"> <img src="https://www.fps-pharma.com/wp-content/uploads/2022/06/pin-mill.jpg" class="fullwidth"></div><div class="col-9 col-sm-10 spaziadess"> Mechanical Mills<p>Mechanical milling remains an important formulation step in the pharmaceutical industry, typically best suited to delivering uniform particle sizes above 20 microns. Whether your drug is in development, starting clinical trials, or ready for commercial production, FPS mills can deliver a mechanical [...]</p></div> <img src="https://www.fps-pharma.com/wp-content/themes/fps/img/ionic-ios-arrow-round-up.svg" class="svgfreccia" alt=""> </a></div></div><div class="carousel-indicators"> <button type="button" data-bs-target="#carouselCorrelate" data-bs-slide-to="0" class="active"></button> <button type="button" data-bs-target="#carouselCorrelate" data-bs-slide-to="1" class=""></button></div></div></div><div class="col-12 col-sm-12 col-md-5 requestcontact"> <span class="intestazionefascia ms-0 mb-5">Request contact</span><div><div class="wpcf7 no-js" id="wpcf7-f1305-o1" lang="en-US" dir="ltr" data-wpcf7-id="1305"><div class="screen-reader-response"><p role="status" aria-live="polite" aria-atomic="true"></p><ul></ul></div><form action="/solutions/fine-grinding-and-micronization/#wpcf7-f1305-o1" method="post" class="wpcf7-form init" aria-label="Contact form" 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value="Kazakhstan">Kazakhstan</option><option value="Kenya">Kenya</option><option value="Kingman Reef">Kingman Reef</option><option value="Kiribati">Kiribati</option><option value="Kerguelen Archipelago">Kerguelen Archipelago</option><option value="Kosovo">Kosovo</option><option value="Kuwait">Kuwait</option><option value="Kyrgyzstan">Kyrgyzstan</option><option value="Laos">Laos</option><option value="Latvia">Latvia</option><option value="Lebanon">Lebanon</option><option value="Lesotho">Lesotho</option><option value="Liberia">Liberia</option><option value="Libya">Libya</option><option value="Liechtenstein">Liechtenstein</option><option value="Lithuania">Lithuania</option><option value="Luxembourg">Luxembourg</option><option value="Macau">Macau</option><option value="Macedonia">Macedonia</option><option value="Madagascar">Madagascar</option><option value="Malawi">Malawi</option><option value="Malaysia">Malaysia</option><option value="Maldives">Maldives</option><option value="Mali">Mali</option><option value="Malta">Malta</option><option value="Marshall Islands">Marshall Islands</option><option value="Martinique">Martinique</option><option value="Mauritania">Mauritania</option><option value="Mauritius">Mauritius</option><option value="Mayotte">Mayotte</option><option value="Mexico">Mexico</option><option value="Micronesia">Micronesia</option><option value="Midway Islands">Midway Islands</option><option value="Moldova">Moldova</option><option value="Monaco">Monaco</option><option value="Mongolia">Mongolia</option><option value="Montenegro">Montenegro</option><option value="Montserrat">Montserrat</option><option value="Morocco">Morocco</option><option value="Mozambique">Mozambique</option><option value="Myanmar">Myanmar</option><option value="Namibia">Namibia</option><option value="Nauru">Nauru</option><option value="Navassa Island">Navassa Island</option><option value="Nepal">Nepal</option><option value="Netherlands">Netherlands</option><option value="Netherlands Antilles">Netherlands Antilles</option><option value="New Caledonia">New Caledonia</option><option value="New Zealand">New Zealand</option><option value="Nicaragua">Nicaragua</option><option value="Niger">Niger</option><option value="Nigeria">Nigeria</option><option value="Niue">Niue</option><option value="Norfolk Island">Norfolk Island</option><option value="North Korea">North Korea</option><option value="North Sea">North Sea</option><option value="Northern Mariana Islands">Northern Mariana Islands</option><option value="Norway">Norway</option><option value="Oman">Oman</option><option value="Pacific Ocean">Pacific Ocean</option><option value="Pakistan">Pakistan</option><option value="Palau">Palau</option><option value="Palmyra Atoll">Palmyra Atoll</option><option value="Panama">Panama</option><option value="Papua New Guinea">Papua New Guinea</option><option value="Paracel Islands">Paracel Islands</option><option value="Paraguay">Paraguay</option><option value="Peru">Peru</option><option value="Philippines">Philippines</option><option value="Pitcairn Islands">Pitcairn Islands</option><option value="Poland">Poland</option><option value="Portugal">Portugal</option><option value="Puerto Rico">Puerto Rico</option><option value="Qatar">Qatar</option><option value="Reunion">Reunion</option><option value="Republic of the Congo">Republic of the Congo</option><option value="Romania">Romania</option><option value="Russia">Russia</option><option value="Rwanda">Rwanda</option><option value="Saint Helena">Saint Helena</option><option value="Saint Kitts and Nevis">Saint Kitts and Nevis</option><option value="Saint Lucia">Saint Lucia</option><option value="Saint Pierre and Miquelon">Saint Pierre and Miquelon</option><option value="Saint Vincent and the Grenadines">Saint Vincent and the Grenadines</option><option value="Samoa">Samoa</option><option value="San Marino">San Marino</option><option value="Sao Tome and Principe">Sao Tome and Principe</option><option value="Saudi Arabia">Saudi Arabia</option><option value="Senegal">Senegal</option><option value="Serbia">Serbia</option><option value="Seychelles">Seychelles</option><option value="Sierra Leone">Sierra Leone</option><option value="Singapore">Singapore</option><option value="Slovakia">Slovakia</option><option value="Slovenia">Slovenia</option><option value="Solomon Islands">Solomon Islands</option><option value="Somalia">Somalia</option><option value="South Africa">South Africa</option><option value="South Georgia and the South Sandwich Islands">South Georgia and the South Sandwich Islands</option><option value="South Korea">South Korea</option><option value="Spain">Spain</option><option value="Spratly Islands">Spratly Islands</option><option value="Sri Lanka">Sri Lanka</option><option value="Sudan">Sudan</option><option value="Suriname">Suriname</option><option value="Svalbard">Svalbard</option><option value="Swaziland">Swaziland</option><option value="Sweden">Sweden</option><option value="Switzerland">Switzerland</option><option value="Syria">Syria</option><option value="Taiwan">Taiwan</option><option value="Tajikistan">Tajikistan</option><option value="Tanzania">Tanzania</option><option value="Thailand">Thailand</option><option value="Togo">Togo</option><option value="Tokelau">Tokelau</option><option value="Tonga">Tonga</option><option value="Trinidad and Tobago">Trinidad and Tobago</option><option value="Tromelin Island">Tromelin Island</option><option value="Tunisia">Tunisia</option><option value="Turkey">Turkey</option><option value="Turkmenistan">Turkmenistan</option><option value="Turks and Caicos Islands">Turks and Caicos Islands</option><option value="Tuvalu">Tuvalu</option><option value="Uganda">Uganda</option><option value="Ukraine">Ukraine</option><option value="United Arab Emirates">United Arab Emirates</option><option value="United Kingdom">United Kingdom</option><option value="USA">USA</option><option value="Uruguay">Uruguay</option><option value="Uzbekistan">Uzbekistan</option><option value="Vanuatu">Vanuatu</option><option value="Venezuela">Venezuela</option><option value="Viet Nam">Viet Nam</option><option value="Virgin Islands">Virgin Islands</option><option value="Wake Island">Wake Island</option><option value="Wallis and Futuna">Wallis and Futuna</option><option value="West Bank">West Bank</option><option value="Western Sahara">Western Sahara</option><option value="Yemen">Yemen</option><option value="Yugoslavia">Yugoslavia</option><option value="Zambia">Zambia</option><option value="Zimbabwe">Zimbabwe</option></select></span></label></div></div><div class="row"><div class="col-12 col-sm-12 col-md-6"><label>Number of products to be micronised* <span class="wpcf7-form-control-wrap" data-name="num-product"><input size="40" maxlength="400" class="wpcf7-form-control wpcf7-text wpcf7-validates-as-required form-control inputprodform" aria-required="true" aria-invalid="false" value="" type="text" name="num-product" /></span></label></div><div class="col-12 col-sm-12 col-md-6"><label>Available quantity for each product* <span class="wpcf7-form-control-wrap" data-name="qnt-product"><input size="40" maxlength="400" class="wpcf7-form-control wpcf7-text wpcf7-validates-as-required form-control inputprodform" aria-required="true" aria-invalid="false" value="" type="text" name="qnt-product" /></span></label></div></div><div class="row"><div class="col-12 col-sm-12 col-md-6"><label>Required PSD* <span class="wpcf7-form-control-wrap" data-name="req-psd"><input size="40" maxlength="400" class="wpcf7-form-control wpcf7-text wpcf7-validates-as-required form-control inputprodform" aria-required="true" aria-invalid="false" value="" type="text" name="req-psd" /></span></label></div><div class="col-12 col-sm-12 col-md-6"><label>Required productivity* <span class="wpcf7-form-control-wrap" data-name="req-productivity"><input size="40" maxlength="400" class="wpcf7-form-control wpcf7-text wpcf7-validates-as-required form-control inputprodform" aria-required="true" aria-invalid="false" value="" type="text" name="req-productivity" /></span></label></div></div><div class="row"><div class="col-12 col-sm-12 col-md-6"><label>MSDS of the product* <span class="wpcf7-form-control-wrap" data-name="msds-product"><input size="40" maxlength="400" class="wpcf7-form-control wpcf7-text wpcf7-validates-as-required form-control inputprodform" aria-required="true" aria-invalid="false" value="" type="text" name="msds-product" /></span></label></div></div><div class="row"><div class="col-12 allargacampo"><label>Notes <span class="wpcf7-form-control-wrap" data-name="your-message"><textarea cols="40" rows="10" maxlength="2000" class="wpcf7-form-control wpcf7-textarea form-control inputprodform" aria-invalid="false" name="your-message"></textarea></span></label></div></div><div class="row"><div class="col-12 privacytext"><span class="wpcf7-form-control-wrap" data-name="acceptance-379"><span class="wpcf7-form-control wpcf7-acceptance"><span class="wpcf7-list-item"><label><input type="checkbox" name="acceptance-379" value="1" aria-invalid="false" /><span class="wpcf7-list-item-label">Yes, I give authorization to manage my personal data according to the EU Reg. 2016/679.</span></label></span></span></span></div></div><div class="row"><div class="col-12 col-sm-12 privacytext"><label><span class="wpcf7-form-control-wrap" data-name="checkbox-newsletter"><span class="wpcf7-form-control wpcf7-checkbox"><span class="wpcf7-list-item first last"><label><input type="checkbox" name="checkbox-newsletter[]" value="Yes" /><span class="wpcf7-list-item-label">Yes</span></label></span></span></span>, I want to subscribe to your newsletter.</label></div></div><div class="row"><div class="col-12"><span class="wpcf7-form-control-wrap recaptcha" data-name="recaptcha"><span data-sitekey="6LcKg0IhAAAAAFEr-s97rppPG60mfTBxwdRSEiIl" class="wpcf7-form-control 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class="cmplz-logo"></div><div class="cmplz-title" id="cmplz-header-1-optin">Manage Cookie Consent</div><div class="cmplz-close" tabindex="0" role="button" aria-label="Close dialog"> <svg aria-hidden="true" focusable="false" data-prefix="fas" data-icon="times" class="svg-inline--fa fa-times fa-w-11" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 352 512"><path fill="currentColor" d="M242.72 256l100.07-100.07c12.28-12.28 12.28-32.19 0-44.48l-22.24-22.24c-12.28-12.28-32.19-12.28-44.48 0L176 189.28 75.93 89.21c-12.28-12.28-32.19-12.28-44.48 0L9.21 111.45c-12.28 12.28-12.28 32.19 0 44.48L109.28 256 9.21 356.07c-12.28 12.28-12.28 32.19 0 44.48l22.24 22.24c12.28 12.28 32.2 12.28 44.48 0L176 322.72l100.07 100.07c12.28 12.28 32.2 12.28 44.48 0l22.24-22.24c12.28-12.28 12.28-32.19 0-44.48L242.72 256z"></path></svg></div></div><div class="cmplz-divider cmplz-divider-header"></div><div class="cmplz-body"><div class="cmplz-message" id="cmplz-message-1-optin">To provide the best experiences, we use technologies like technical cookies to store and/or access device information. The analytics data聽are saved anonymously and are not shared with any external service.</div><div class="cmplz-categories"> <details class="cmplz-category cmplz-functional" > <summary> <span class="cmplz-category-header"> <span class="cmplz-category-title">Functional</span> <span class='cmplz-always-active'> <span class="cmplz-banner-checkbox"> <input type="checkbox" id="cmplz-functional-optin" data-category="cmplz_functional" class="cmplz-consent-checkbox cmplz-functional" size="40" value="1"/> <label class="cmplz-label" for="cmplz-functional-optin" tabindex="0"><span class="screen-reader-text">Functional</span></label> </span> Always active </span> <span class="cmplz-icon cmplz-open"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512" height="18" ><path d="M224 416c-8.188 0-16.38-3.125-22.62-9.375l-192-192c-12.5-12.5-12.5-32.75 0-45.25s32.75-12.5 45.25 0L224 338.8l169.4-169.4c12.5-12.5 32.75-12.5 45.25 0s12.5 32.75 0 45.25l-192 192C240.4 412.9 232.2 416 224 416z"/></svg> </span> </span> </summary><div class="cmplz-description"> <span class="cmplz-description-functional">The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.</span></div> </details> <details class="cmplz-category cmplz-preferences" > <summary> <span class="cmplz-category-header"> <span class="cmplz-category-title">Preferences</span> <span class="cmplz-banner-checkbox"> <input type="checkbox" id="cmplz-preferences-optin" data-category="cmplz_preferences" class="cmplz-consent-checkbox cmplz-preferences" size="40" value="1"/> <label class="cmplz-label" for="cmplz-preferences-optin" tabindex="0"><span class="screen-reader-text">Preferences</span></label> </span> <span class="cmplz-icon cmplz-open"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512" height="18" ><path d="M224 416c-8.188 0-16.38-3.125-22.62-9.375l-192-192c-12.5-12.5-12.5-32.75 0-45.25s32.75-12.5 45.25 0L224 338.8l169.4-169.4c12.5-12.5 32.75-12.5 45.25 0s12.5 32.75 0 45.25l-192 192C240.4 412.9 232.2 416 224 416z"/></svg> </span> </span> </summary><div class="cmplz-description"> <span class="cmplz-description-preferences">The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.</span></div> </details> <details class="cmplz-category cmplz-statistics" > <summary> <span class="cmplz-category-header"> <span class="cmplz-category-title">Statistics</span> <span class="cmplz-banner-checkbox"> <input type="checkbox" id="cmplz-statistics-optin" data-category="cmplz_statistics" class="cmplz-consent-checkbox cmplz-statistics" size="40" value="1"/> <label class="cmplz-label" for="cmplz-statistics-optin" tabindex="0"><span class="screen-reader-text">Statistics</span></label> </span> <span class="cmplz-icon cmplz-open"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512" height="18" ><path d="M224 416c-8.188 0-16.38-3.125-22.62-9.375l-192-192c-12.5-12.5-12.5-32.75 0-45.25s32.75-12.5 45.25 0L224 338.8l169.4-169.4c12.5-12.5 32.75-12.5 45.25 0s12.5 32.75 0 45.25l-192 192C240.4 412.9 232.2 416 224 416z"/></svg> </span> </span> </summary><div class="cmplz-description"> <span class="cmplz-description-statistics">The technical storage or access that is used exclusively for statistical purposes.</span> <span class="cmplz-description-statistics-anonymous">The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.</span></div> </details> <details class="cmplz-category cmplz-marketing" > <summary> <span class="cmplz-category-header"> <span class="cmplz-category-title">Marketing</span> <span class="cmplz-banner-checkbox"> <input type="checkbox" id="cmplz-marketing-optin" data-category="cmplz_marketing" class="cmplz-consent-checkbox cmplz-marketing" size="40" value="1"/> <label class="cmplz-label" for="cmplz-marketing-optin" tabindex="0"><span class="screen-reader-text">Marketing</span></label> </span> <span class="cmplz-icon cmplz-open"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512" height="18" ><path d="M224 416c-8.188 0-16.38-3.125-22.62-9.375l-192-192c-12.5-12.5-12.5-32.75 0-45.25s32.75-12.5 45.25 0L224 338.8l169.4-169.4c12.5-12.5 32.75-12.5 45.25 0s12.5 32.75 0 45.25l-192 192C240.4 412.9 232.2 416 224 416z"/></svg> </span> </span> </summary><div class="cmplz-description"> <span class="cmplz-description-marketing">The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.</span></div> </details></div></div><div class="cmplz-links cmplz-information"> <a class="cmplz-link cmplz-manage-options cookie-statement" href="#" data-relative_url="#cmplz-manage-consent-container">Manage options</a> <a class="cmplz-link cmplz-manage-third-parties cookie-statement" href="#" data-relative_url="#cmplz-cookies-overview">Manage services</a> <a class="cmplz-link cmplz-manage-vendors tcf cookie-statement" href="#" data-relative_url="#cmplz-tcf-wrapper">Manage {vendor_count} vendors</a> <a class="cmplz-link cmplz-external cmplz-read-more-purposes tcf" target="_blank" rel="noopener noreferrer nofollow" 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