Specific Biomarker Level and Function Outcome Changes in Treatment of Patients with Frozen Shoulder Using Dextrose Prolotherapy Injection

<!DOCTYPE html> <html lang="en" dir="ltr"> <head>  <script async src="https://www.googletagmanager.com/gtag/js?id=G-P63WKM1TM1"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-P63WKM1TM1'); </script>  <script type="text/javascript" > (function(m,e,t,r,i,k,a){m[i]=m[i]||function(){(m[i].a=m[i].a||[]).push(arguments)}; m[i].l=1*new Date(); for (var j = 0; j < document.scripts.length; j++) {if (document.scripts[j].src === r) { return; }} k=e.createElement(t),a=e.getElementsByTagName(t)[0],k.async=1,k.src=r,a.parentNode.insertBefore(k,a)}) (window, document, "script", "https://mc.yandex.ru/metrika/tag.js", "ym"); ym(55165297, "init", { clickmap:false, trackLinks:true, accurateTrackBounce:true, webvisor:false }); </script> <noscript><div><img src="https://mc.yandex.ru/watch/55165297" style="position:absolute; left:-9999px;" alt="" /></div></noscript>    <title>Specific Biomarker Level and Function Outcome Changes in Treatment of Patients with Frozen Shoulder Using Dextrose Prolotherapy Injection</title> <meta name="description" content="Specific Biomarker Level and Function Outcome Changes in Treatment of Patients with Frozen Shoulder Using Dextrose Prolotherapy Injection"> <meta name="keywords" content="Frozen Shoulder, ROM, DASH Score, prolotherapy, MMP-1, TIMP-1."> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <meta name="citation_title" content="Specific Biomarker Level and Function Outcome Changes in Treatment of Patients with Frozen Shoulder Using Dextrose Prolotherapy Injection"> <meta name="citation_author" content="Nuralam Sam"> <meta name="citation_author" content="Irawan Yusuf"> <meta name="citation_author" content="Irfan Idris"> <meta name="citation_author" content="Endi Adnan"> <meta name="citation_publication_date" content="2023/03/09"> <meta 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action="https://publications.waset.org/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value=""> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 33093</div> </div> </div> </div> <div class="card publication-listing mt-3 mb-3"> <h5 class="card-header" style="font-size:.9rem">Specific Biomarker Level and Function Outcome Changes in Treatment of Patients with Frozen Shoulder Using Dextrose Prolotherapy Injection</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Nuralam%20Sam">Nuralam Sam</a>, <a href="https://publications.waset.org/search?q=Irawan%20Yusuf"> Irawan Yusuf</a>, <a href="https://publications.waset.org/search?q=Irfan%20Idris"> Irfan Idris</a>, <a href="https://publications.waset.org/search?q=Endi%20Adnan"> Endi Adnan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>Frozen shoulder (FS) is an insidious, painful condition caused by an inflammatory condition that causes fibrosis of the glenohumeral joint capsule, which causes progressive stiffness and restriction of the active and passive range of motion (ROM) of the shoulder. The studies of FS are still limited. This single-blinded randomized controlled trial involved participants with FS. The study participants were divided into two groups. The Prolotherapy group was the study group, and the Normal Saline (NS) group was the control group. Both groups were given injections at weeks 0, 2, 4, and 6. Matrix Metalloproteinase-1 (MMP-1) and Tissue Inhibitor Metalloproteinase-1 (TIMP-1) were measured at week six and week 12 after the last injection. The Disabilities of The Arm, Shoulder, and Hand (DASH) Score and ROM were measured at weeks 0, 2, 4, and 6 before and after injection and week 12. Comparative analysis was performed using repeated measures Paired T-Test, and data processing to assess correlation was using ANOVA. The result showed a significant decrease in The Disability of the Arm, Shoulder, and Hand (DASH) score in prolotherapy injection patients in each measurement week (p < 0.05). While the measurement of ROM, each direction of shoulder motion showed a significant difference in average each week, from week 0 to week 6 (p < 0.05). Dextrose prolotherapy injection results significantly improved the functional outcome of the shoulder joint and ROM. They did not show significant results in assessing the specific biomarker, MMP-1, and TIMP-1, in tissue repair. This study suggests an alternative to injection prolotherapy in FS patients; it has minimal adverse effects and is efficient in time and cost.</p> <iframe src="https://publications.waset.org/10012998.pdf" style="width:100%; height:400px;" frameborder="0"></iframe> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Frozen%20Shoulder" title="Frozen Shoulder">Frozen Shoulder</a>, <a href="https://publications.waset.org/search?q=ROM" title=" ROM"> ROM</a>, <a href="https://publications.waset.org/search?q=DASH%20Score" title=" DASH Score"> DASH Score</a>, <a href="https://publications.waset.org/search?q=prolotherapy" title=" prolotherapy"> prolotherapy</a>, <a href="https://publications.waset.org/search?q=MMP-1" title=" MMP-1"> MMP-1</a>, <a href="https://publications.waset.org/search?q=TIMP-1." title=" TIMP-1."> TIMP-1.</a> </p> <a href="https://publications.waset.org/10012998/specific-biomarker-level-and-function-outcome-changes-in-treatment-of-patients-with-frozen-shoulder-using-dextrose-prolotherapy-injection" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/10012998/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/10012998/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/10012998/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/10012998/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/10012998/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/10012998/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/10012998/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/10012998/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/10012998/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/10012998/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/10012998.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">475</span> </span> <p class="card-text"><strong>References:</strong></p> <br>[1] Hubbard MJ, Hildebrand BA, Battafarano MM, Battafarano DF. (2018). Common Soft Tissue Musculoskeletal Pain Disorders. Prim Care. Jun; 45(2):289-303. (PubMed). <br>[2] Joseph D. Zuckerman; Andrew Rokito (2011). Frozen shoulder: a consensus definition, 20(2), 0–325. doi:10.1016/j.jse.2010.07.008 <br>[3] Cho, C.-H., Song, K.-S., Kim, B.-S., Kim, D. H., & Lho, Y.-M. (2018). Biological Aspect of Pathophysiology for Frozen Shoulder. BioMed Research International, 2018, 1–8. doi:10.1155/2018/7274517 <br>[4] Lubis, A. (2013). Matrix metalloproteinase, tissue inhibitor of metalloproteinase and transforming growth factor-beta 1 in frozen shoulder, and their changes as response to intensive stretching and supervised neglect exercise. Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 18. doi : 10.1007/s00776-013-0387-0 <br>[5] Kim, Y.-S., Kim, J.-M., Lee, Y.-G., Hong, O.-K., Kwon, H.-S., & Ji, J.-H. (2013). Intercellular Adhesion Molecule-1 (ICAM-1, CD54) Is Increased in Adhesive Capsulitis. The Journal of Bone and Joint Surgery-American Volume, 95(4), e18–1– 8. doi:10.2106/jbjs.k.00525 <br>[6] Lee, H. V.; Lee, S. J.; Nazarian, A.; Rodriguez, E. K. (2016). Adhesive capsulitis of the shoulder: review of pathophysiology and current clinical treatments. Shoulder & Elbow, 9(2), 75-84. doi:10.1177/1758573216676786. <br>[7] Xiao RC, DeAngelis JP, Smith CC, Ramappa AJ. (2017). Evaluating Nonoperative Treatments for Adhesive Capsulitis. WINTERJ Surg Orthop Adv. 26(4):193-199. <br>[8] Zreik NH, Malik RA, Charalambous CP. (2016). Adhesive capsulitis of the shoulder and diabetes: a metaanalysis of prevalence. Muscles Ligaments Tendons J; 6:26. <br>[9] Nasiri A., Jahromi M., Vafei M. A., Parvin R., Fakheri M. S., Sadeghi S. (2021). Comparison of the Effectiveness of Ultrasound‑Guided Prolotherapy in Supraspinatus Tendon with Ultrasound‑Guided Corticosteroid Injection of Subacromial Subdeltoid Bursa in Rotator Cuff‑Related Shoulder Pain: A Clinical Trial Study. Advance Biomed Research, 10 (12). doi: 10.4103/abr.abr_181_20 <br>[10] Robinson, D. M., Eng, C., Makovitch, S., Rothenberg, J. B., DeLuca, S., Douglas, S., … Borg-Stein, J. (2021). Non-operative orthobiologic use for rotator cuff disorders and glenohumeral osteoarthritis: A systematic review. Journal of Back and Musculoskeletal Rehabilitation, 34(1), 17–32. doi:10.3233/bmr-201844 <br>[11] Bertrand, H., Reeves, K. D., Bennett, C. J., Bicknell, S., & Cheng, A.-L. (2016). Dextrose Prolotherapy Versus Control Injections in Painful Rotator Cuff Tendinopathy. Archives of Physical Medicine and Rehabilitation, 97(1), 17–25. doi:10.1016/j.apmr.2015.08.412 <br>[12] Lin, C.-L., Huang, C.-C., & Huang, S.-W. (2019). Effects of hypertonic dextrose injection in chronic supraspinatus tendinopathy of the shoulder: a randomized placebo-controlled trial. 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Specific Biomarker Level and Function Outcome Changes in Treatment of Patients with Frozen Shoulder Using Dextrose Prolotherapy Injection