The Clinical Proteomic Technologies for Cancer

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aria-hidden="true"></i> PRINT</a></div> </div> <h1 id="page-title" class="title">Carboxypeptidase E (mouse)</h1> <hr /> </div> <div id="block-system-main" class="block block-system block-system-main" > <div class="content" id="detail_page_content"> <article id="node-27" class="node node-page view-mode-full" about="https://proteomics.cancer.gov/antibody-portal/available-antibodies/antibody-portal" typeof="foaf:Document"> <span property="dc:title" content="Antibody Portal" class="rdf-meta element-hidden"></span> <span property="sioc:num_replies" content="0" datatype="xsd:integer" class="rdf-meta element-hidden"></span> </article>  <div id="search-fields-container_antibody-browse"> <a title="Expand all page details" href="javascript:void(0);" onclick="showAllAntigenDataBlock('open',3)">Expand All</a> - <a title="Collapse all page details" href="javascript:void(0);" onclick="showAllAntigenDataBlock('close',3)">Collapse All</a> </div> <div class="clear"></div> <div id="detail-menu"> <div class="detail-menu-title"><h2>Antibodies</h2></div> <ul> <li class="antibody-name"> <h3><a href="#CPTC-CPE-1">CPTC-CPE-1</a></h3>  <a class="manageMenuBlock-link" href="javascript:void(0)" id="top-antibody-1" onclick="manageMenuBlock(this.id); showDataBlock('antibody-1',false)">[hide details]</a> <div class="top_links" id="menu-top-antibody-1"> <ul class="sub-menu"> <li><a href="#CPTC-CPE-1-Background">Background</a>| <a href="#CPTC-CPE-1-Characterization">Characterization Data</a></li> </ul> </div> </li> <li class="antibody-name"> <h3><a href="#CPTC-CPE-2">CPTC-CPE-2</a></h3>  <a class="manageMenuBlock-link" href="javascript:void(0)" id="top-antibody-2" onclick="manageMenuBlock(this.id); showDataBlock('antibody-2',false)">[hide details]</a> <div class="top_links" id="menu-top-antibody-2"> <ul class="sub-menu"> <li><a href="#CPTC-CPE-2-Background">Background</a>| <a href="#CPTC-CPE-2-Characterization">Characterization Data</a></li> </ul> </div> </li> <li class="antibody-name"> <h3><a href="#CPTC-CPE-3">CPTC-CPE-3</a></h3>  <a class="manageMenuBlock-link" href="javascript:void(0)" id="top-antibody-3" onclick="manageMenuBlock(this.id); showDataBlock('antibody-3',false)">[hide details]</a> <div class="top_links" id="menu-top-antibody-3"> <ul class="sub-menu"> <li><a href="#CPTC-CPE-3-Background">Background</a>| <a href="#CPTC-CPE-3-Characterization">Characterization Data</a></li> </ul> </div> </li> </ul> <div class="detail-menu-title"><h2>Antigen</h2></div> <ul> <li class="antibody-name"><h3><a href="#Carboxypeptidase_E_(mouse)">Carboxypeptidase E (mouse)</a></h3> <a title="hide/show details" class="manageMenuBlock-link" href="javascript:void(0)" id="top-antigen" onclick="manageMenuBlock(this.id); showDataBlock('block-antigen')">[hide details]</a> <div class="top_links" id="menu-top-antigen"> <ul class="sub-menu"> <li><a href="#Carboxypeptidase E (mouse)-Background">Background</a>| <a href="#Carboxypeptidase E (mouse)-Characterization">Characterization Data</a>| <a href="#Carboxypeptidase E (mouse)-SOPs">SOPs</a>| <a href="#Carboxypeptidase E (mouse)-Links">Links</a></li> </ul> </div> </li> </ul> </div> <a name="CPTC-CPE-1"></a> <div class="well"> <div class="detail-type-header"> <a title="hide/show details" class="manageMenuBlock-link" href="javascript:void(0)" onclick="showDataBlock('antibody-1',true)"> <h4><i class="fa fa-minus icon-antibody-1" aria-hidden="true"></i>Antibody: CPTC-CPE-1</h4> </a> </div> <div id="antibody-menu-1" title="Click to display Antibody data" class="block_record_menu_down_icon" onclick="manageMenuBlock('top-antibody-1'); showDataBlock('antibody-1',false)"> </div> <div class="block_record" id="antibody-1"> <a name="CPTC-CPE-1-Background"></a> <h5 class="nopadding">Background</h5> <div class="detail-label"><p>Catalog Number:</p></div> <div class="detail-value"><p>CPTC-CPE-1</p></div> <div class="clear"></div> <div class="detail-label"><p>RRID:</p></div> <div class="detail-value"><p>AB_2756531</p></div> <div class="clear"></div> <div class="detail-label"><p>Target Antigen:</p></div> <div class="detail-value"><p>Carboxypeptidase E (mouse)</p></div> <div class="clear"></div> <div class="detail-label"><p>Isotype:</p></div> <div class="detail-value"><p>IgG2b</p></div> <div class="clear"></div> <div class="detail-label"><p>Species:</p></div> <div class="detail-value"><p>Mouse Monoclonal Antibody</p></div> <div class="clear"></div> <div class="detail-label"><p>Last Updated:</p></div> <div class="detail-value"><p>08/24/2022</p></div> <div class="clear"></div> <div class="detail-label"><p>Antigen Recognition(s):</p></div> <div class="detail-value"><p>Recombinant Full-length</p></div> <div class="clear"></div> <h5>Purchase</h5> <ul class="url-list"> <a name="CPTC-CPE-1-Links"></a> <li class="cart"> <strong>DSHB</strong> <a href="../cart/Q1BUQy1DUEUtMQ%3D%3D"> CPTC-CPE-1 </a> </li> </ul> <a name="CPTC-CPE-1-Characterization"></a> <h5>Characterization Data <a title="Compare characterization data" class="show-for-medium-up" href="#" data-open="compareModal" onclick="showCompare(213);">[Compare Characterization Data]</a></h5> <div id="characterization_results_0"> <div class="image-container"> <a href="#" class="characterization_toggle closed" data-char-toggle="characterization_1"> <h6><i class="fa fa-plus characterization_1" aria-hidden="true"></i>  IHC HPA</h6> </a> <div class="characterization_container" id="characterization_1"> Download <a href='/file/download/antibody_original/ddb7823998e555987884a20adb73156e' title='Click to download This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)'>This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)</a> (350.4 KB) <h3 class="detail-type-header align-left">CPTC-CPE-1 Evaluation by the Human Protein Atlas</h3> <div><p>Result: <strong>Negative</strong></p></div> <p class="detail-type-text">This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)</p><br /> <div class="download-file-container"> <div class="antibody-char-sop-box"> <h3 class="detail-type-header">Characterization SOP Files</h3> <ul class="sop-file-list"> <li> <img style="border: 0px;" align="absmiddle" alt="Download file document type" src="/resources/images/site/application_pdf.gif" />  <a title="Download Antibody Evaluation by Human Protein Atlas (62.6 KB)" href="/file/download/characterization_image_sop/2b9c44e43c5c9761c168c019666b3d8f">Antibody Evaluation by Human Protein Atlas (62.6 KB)</a></li> </ul></div> </div> </div> </div> <div class="image-container"> <a href="#" class="characterization_toggle closed" data-char-toggle="characterization_2"> <h6><i class="fa fa-plus characterization_2" aria-hidden="true"></i>  Indirect ELISA</h6> </a> <div class="characterization_container" id="characterization_2"> <div class="center_align"> <a data-open="characterization_image_2" href="#"> <img class="characterization_image image-characterization" data-full-sized-image="characterization_image_2" data-full-sized-image-path="/file/view/antibody_original/22662e83789c1687dcf9cc08d311df69" height="233" width="255" alt="Click to enlarge image Indirect ELISA (ie, binding of Antibody to Antigen coated plate). Note: B50% represents the concentration of Ab required to generate 50% of maximum binding." src="/file/view/antibody/f6ae3387e00065299d3510e357a51301" data-width="500" /> </a> <span>Click image to enlarge</span> </div> <div id="characterization_image_2" class="reveal" style="width: 500px;" data-reveal aria-labelledby="firstModalTitle" aria-hidden="true" role="dialog"> <div class="close-characterization-image" title="Click to close the IHC Cell Line Reference Image"> <a class="close-reveal-modal" aria-label="Close" href="#">×</a> </div> <img alt="Indirect ELISA (ie, binding of Antibody to Antigen coated plate). Note: B50% represents the concentration of Ab required to generate 50% of maximum binding." src="" /> </div> <h3 class="detail-type-header align-left">CPTC-CPE-1 Indirect ELISA</h3> <div><p>Result: <strong>Positive</strong></p></div> <p class="detail-type-text">Indirect ELISA (ie, binding of Antibody to Antigen coated plate). Note: B50% represents the concentration of Ab required to generate 50% of maximum binding.</p><br /> <div class="download-file-container"> <div class="antibody-char-sop-box"> <h3 class="detail-type-header">Characterization SOP Files</h3> <ul class="sop-file-list"> <li> <img style="border: 0px;" align="absmiddle" alt="Download file document type" src="/resources/images/site/application_pdf.gif" />  <a title="Download Evaluation using Indirect ELISA (250.5 KB)" href="/file/download/characterization_image_sop/e4795ed47b3aef0a402939ebbe36f0a1">Evaluation using Indirect ELISA (250.5 KB)</a></li> </ul></div> </div> </div> </div> <div class="image-container"> <a href="#" class="characterization_toggle closed" data-char-toggle="characterization_3"> <h6><i class="fa fa-plus characterization_3" aria-hidden="true"></i>  Western Blot - Recombinant Protein or Peptide</h6> </a> <div class="characterization_container" id="characterization_3"> <div class="center_align"> <a data-open="characterization_image_3" href="#"> <img class="characterization_image image-characterization" data-full-sized-image="characterization_image_3" data-full-sized-image-path="/file/view/antibody_original/778af26da1b3b84fe8ac9e06666dc452" height="255" width="105" alt="Click to enlarge image Western blot of CPTC-CPE-1 antibody with full length CPE recombinant protein (NCI ID#00236)." src="/file/view/antibody/4b8c491e8e72c837a40f6f310009ed3a" data-width="176" /> </a> <span>Click image to enlarge</span> </div> <div id="characterization_image_3" class="reveal" style="width: 176px;" data-reveal aria-labelledby="firstModalTitle" aria-hidden="true" role="dialog"> <div class="close-characterization-image" title="Click to close the IHC Cell Line Reference Image"> <a class="close-reveal-modal" aria-label="Close" href="#">×</a> </div> <img alt="Western blot of CPTC-CPE-1 antibody with full length CPE recombinant protein (NCI ID#00236)." src="" /> </div> <h3 class="detail-type-header align-left">CPTC-CPE-1 Western blot</h3> <div><p>Result: <strong>Positive</strong></p></div> <p class="detail-type-text">Western blot of CPTC-CPE-1 antibody with full length CPE recombinant protein (NCI ID#00236).</p><br /> <div class="download-file-container"> <div class="antibody-char-sop-box"> <h3 class="detail-type-header">Characterization SOP Files</h3> <ul class="sop-file-list"> <li> <img style="border: 0px;" align="absmiddle" alt="Download file document type" src="/resources/images/site/application_pdf.gif" />  <a title="Download Evaluation using Western Blot (108.9 KB)" href="/file/download/characterization_image_sop/b367b4a842bf659e980a30556dc349b3">Evaluation using Western Blot (108.9 KB)</a></li> </ul></div> </div> </div> </div> </div> <div class="top-link"><a title="Back to top of page" href="#top">[top]</a></div> <a name="CPTC-CPE-1-SOPs"></a> <div class="clear"></div> </div> </div> <a name="CPTC-CPE-2"></a> <div class="well"> <div class="detail-type-header"> <a title="hide/show details" class="manageMenuBlock-link" href="javascript:void(0)" onclick="showDataBlock('antibody-2',true)"> <h4><i class="fa fa-minus icon-antibody-2" aria-hidden="true"></i>Antibody: CPTC-CPE-2</h4> </a> </div> <div id="antibody-menu-2" title="Click to display Antibody data" class="block_record_menu_down_icon" onclick="manageMenuBlock('top-antibody-2'); showDataBlock('antibody-2',false)"> </div> <div class="block_record" id="antibody-2"> <a name="CPTC-CPE-2-Background"></a> <h5 class="nopadding">Background</h5> <div class="detail-label"><p>Catalog Number:</p></div> <div class="detail-value"><p>CPTC-CPE-2</p></div> <div class="clear"></div> <div class="detail-label"><p>RRID:</p></div> <div class="detail-value"><p>AB_2756532</p></div> <div class="clear"></div> <div class="detail-label"><p>Target Antigen:</p></div> <div class="detail-value"><p>Carboxypeptidase E (mouse)</p></div> <div class="clear"></div> <div class="detail-label"><p>Isotype:</p></div> <div class="detail-value"><p>IgG2c</p></div> <div class="clear"></div> <div class="detail-label"><p>Species:</p></div> <div class="detail-value"><p>Mouse Monoclonal Antibody</p></div> <div class="clear"></div> <div class="detail-label"><p>Last Updated:</p></div> <div class="detail-value"><p>08/24/2022</p></div> <div class="clear"></div> <div class="detail-label"><p>Antigen Recognition(s):</p></div> <div class="detail-value"><p>Recombinant Full-length</p></div> <div class="clear"></div> <h5>Purchase</h5> <ul class="url-list"> <a name="CPTC-CPE-2-Links"></a> <li class="cart"> <strong>DSHB</strong> <a href="../cart/Q1BUQy1DUEUtMg%3D%3D"> CPTC-CPE-2 </a> </li> </ul> <a name="CPTC-CPE-2-Characterization"></a> <h5>Characterization Data <a title="Compare characterization data" class="show-for-medium-up" href="#" data-open="compareModal" onclick="showCompare(213);">[Compare Characterization Data]</a></h5> <div id="characterization_results_1"> <div class="image-container"> <a href="#" class="characterization_toggle closed" data-char-toggle="characterization_4"> <h6><i class="fa fa-plus characterization_4" aria-hidden="true"></i>  IHC HPA</h6> </a> <div class="characterization_container" id="characterization_4"> Download <a href='/file/download/antibody_original/ab299d38e79a9664ee09a83c2a9b7ec4' title='Click to download This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)'>This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)</a> (328.9 KB) <h3 class="detail-type-header align-left">CPTC-CPE-2 Evaluation by the Human Protein Atlas</h3> <div><p>Result: <strong>Negative</strong></p></div> <p class="detail-type-text">This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)</p><br /> <div class="download-file-container"> <div class="antibody-char-sop-box"> <h3 class="detail-type-header">Characterization SOP Files</h3> <ul class="sop-file-list"> <li> <img style="border: 0px;" align="absmiddle" alt="Download file document type" src="/resources/images/site/application_pdf.gif" />  <a title="Download Antibody Evaluation by Human Protein Atlas (62.6 KB)" href="/file/download/characterization_image_sop/2b9c44e43c5c9761c168c019666b3d8f">Antibody Evaluation by Human Protein Atlas (62.6 KB)</a></li> </ul></div> </div> </div> </div> <div class="image-container"> <a href="#" class="characterization_toggle closed" data-char-toggle="characterization_5"> <h6><i class="fa fa-plus characterization_5" aria-hidden="true"></i>  Indirect ELISA</h6> </a> <div class="characterization_container" id="characterization_5"> <div class="center_align"> <a data-open="characterization_image_5" href="#"> <img class="characterization_image image-characterization" data-full-sized-image="characterization_image_5" data-full-sized-image-path="/file/view/antibody_original/b214b8b5c1b3683af30c808ff8a847db" height="233" width="255" alt="Click to enlarge image Indirect ELISA (ie, binding of Antibody to Antigen coated plate). Note: B50% represents the concentration of Ab required to generate 50% of maximum binding." src="/file/view/antibody/e6e78ceb62bfd95443ad5b09abc75499" data-width="500" /> </a> <span>Click image to enlarge</span> </div> <div id="characterization_image_5" class="reveal" style="width: 500px;" data-reveal aria-labelledby="firstModalTitle" aria-hidden="true" role="dialog"> <div class="close-characterization-image" title="Click to close the IHC Cell Line Reference Image"> <a class="close-reveal-modal" aria-label="Close" href="#">×</a> </div> <img alt="Indirect ELISA (ie, binding of Antibody to Antigen coated plate). Note: B50% represents the concentration of Ab required to generate 50% of maximum binding." src="" /> </div> <h3 class="detail-type-header align-left">CPTC-CPE-2 Indirect ELISA</h3> <div><p>Result: <strong>Positive</strong></p></div> <p class="detail-type-text">Indirect ELISA (ie, binding of Antibody to Antigen coated plate). Note: B50% represents the concentration of Ab required to generate 50% of maximum binding.</p><br /> <div class="download-file-container"> <div class="antibody-char-sop-box"> <h3 class="detail-type-header">Characterization SOP Files</h3> <ul class="sop-file-list"> <li> <img style="border: 0px;" align="absmiddle" alt="Download file document type" src="/resources/images/site/application_pdf.gif" />  <a title="Download Evaluation using Indirect ELISA (250.5 KB)" href="/file/download/characterization_image_sop/e4795ed47b3aef0a402939ebbe36f0a1">Evaluation using Indirect ELISA (250.5 KB)</a></li> </ul></div> </div> </div> </div> <div class="image-container"> <a href="#" class="characterization_toggle closed" data-char-toggle="characterization_6"> <h6><i class="fa fa-plus characterization_6" aria-hidden="true"></i>  Western Blot - Recombinant Protein or Peptide</h6> </a> <div class="characterization_container" id="characterization_6"> <div class="center_align"> <a data-open="characterization_image_6" href="#"> <img class="characterization_image image-characterization" data-full-sized-image="characterization_image_6" data-full-sized-image-path="/file/view/antibody_original/b1e086ce2e9b2b8b99769cbed9717613" height="255" width="106" alt="Click to enlarge image Western blot of CPTC-CPE-2 antibody with full length CPE recombinant protein (NCI ID#00236)." src="/file/view/antibody/07cac6d3f11a6f404d4bd6b378657efb" data-width="177" /> </a> <span>Click image to enlarge</span> </div> <div id="characterization_image_6" class="reveal" style="width: 177px;" data-reveal aria-labelledby="firstModalTitle" aria-hidden="true" role="dialog"> <div class="close-characterization-image" title="Click to close the IHC Cell Line Reference Image"> <a class="close-reveal-modal" aria-label="Close" href="#">×</a> </div> <img alt="Western blot of CPTC-CPE-2 antibody with full length CPE recombinant protein (NCI ID#00236)." src="" /> </div> <h3 class="detail-type-header align-left">CPTC-CPE-2 Western blot</h3> <div><p>Result: <strong>Positive</strong></p></div> <p class="detail-type-text">Western blot of CPTC-CPE-2 antibody with full length CPE recombinant protein (NCI ID#00236).</p><br /> <div class="download-file-container"> <div class="antibody-char-sop-box"> <h3 class="detail-type-header">Characterization SOP Files</h3> <ul class="sop-file-list"> <li> <img style="border: 0px;" align="absmiddle" alt="Download file document type" src="/resources/images/site/application_pdf.gif" />  <a title="Download Evaluation using Western Blot (108.9 KB)" href="/file/download/characterization_image_sop/b367b4a842bf659e980a30556dc349b3">Evaluation using Western Blot (108.9 KB)</a></li> </ul></div> </div> </div> </div> </div> <div class="top-link"><a title="Back to top of page" href="#top">[top]</a></div> <a name="CPTC-CPE-2-SOPs"></a> <div class="clear"></div> </div> </div> <a name="CPTC-CPE-3"></a> <div class="well"> <div class="detail-type-header"> <a title="hide/show details" class="manageMenuBlock-link" href="javascript:void(0)" onclick="showDataBlock('antibody-3',true)"> <h4><i class="fa fa-minus icon-antibody-3" aria-hidden="true"></i>Antibody: CPTC-CPE-3</h4> </a> </div> <div id="antibody-menu-3" title="Click to display Antibody data" class="block_record_menu_down_icon" onclick="manageMenuBlock('top-antibody-3'); showDataBlock('antibody-3',false)"> </div> <div class="block_record" id="antibody-3"> <a name="CPTC-CPE-3-Background"></a> <h5 class="nopadding">Background</h5> <div class="detail-label"><p>Catalog Number:</p></div> <div class="detail-value"><p>CPTC-CPE-3</p></div> <div class="clear"></div> <div class="detail-label"><p>RRID:</p></div> <div class="detail-value"><p>AB_2756533</p></div> <div class="clear"></div> <div class="detail-label"><p>Target Antigen:</p></div> <div class="detail-value"><p>Carboxypeptidase E (mouse)</p></div> <div class="clear"></div> <div class="detail-label"><p>Isotype:</p></div> <div class="detail-value"><p>IgG1</p></div> <div class="clear"></div> <div class="detail-label"><p>Species:</p></div> <div class="detail-value"><p>Mouse Monoclonal Antibody</p></div> <div class="clear"></div> <div class="detail-label"><p>Last Updated:</p></div> <div class="detail-value"><p>01/03/2024</p></div> <div class="clear"></div> <div class="detail-label"><p>Antigen Recognition(s):</p></div> <div class="detail-value"><p>Recombinant Full-length</p></div> <div class="clear"></div> <h5>Purchase</h5> <ul class="url-list"> <a name="CPTC-CPE-3-Links"></a> <li class="cart"> <strong>DSHB</strong> <a href="../cart/Q1BUQy1DUEUtMw%3D%3D"> CPTC-CPE-3 </a> </li> </ul> <h5>External Links</h5> <ul class="url-list"> <li class="link"> <strong>Human Protein Atlas</strong> <a target="_blank" title="Link to CPTC-CPE-3" href="https://www.proteinatlas.org/ENSG00000109472-CPE/summary/antibody"> CPTC-CPE-3 </a> </li> </ul> <a name="CPTC-CPE-3-Characterization"></a> <h5>Characterization Data <a title="Compare characterization data" class="show-for-medium-up" href="#" data-open="compareModal" onclick="showCompare(213);">[Compare Characterization Data]</a></h5> <div id="characterization_results_2"> <div class="image-container"> <a href="#" class="characterization_toggle closed" data-char-toggle="characterization_7"> <h6><i class="fa fa-plus characterization_7" aria-hidden="true"></i>  IHC HPA</h6> </a> <div class="characterization_container" id="characterization_7"> Download <a href='/file/download/antibody_original/0bcf0c56affeba689c5d35c186bd0f38' title='Click to download This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)'>This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)</a> (196.0 KB) <h3 class="detail-type-header align-left">CPTC-CPE-3 Evaluation by the Human Protein Atlas</h3> <div><p>Result: <strong>Positive</strong></p></div> <p class="detail-type-text">This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)</p><br /> <div class="download-file-container"> <div class="antibody-char-sop-box"> <h3 class="detail-type-header">Characterization SOP Files</h3> <ul class="sop-file-list"> <li> <img style="border: 0px;" align="absmiddle" alt="Download file document type" src="/resources/images/site/application_pdf.gif" />  <a title="Download Antibody Evaluation by Human Protein Atlas (62.6 KB)" href="/file/download/characterization_image_sop/2b9c44e43c5c9761c168c019666b3d8f">Antibody Evaluation by Human Protein Atlas (62.6 KB)</a></li> </ul></div> </div> </div> </div> <div class="image-container"> <a href="#" class="characterization_toggle closed" data-char-toggle="characterization_8"> <h6><i class="fa fa-plus characterization_8" aria-hidden="true"></i>  Indirect ELISA</h6> </a> <div class="characterization_container" id="characterization_8"> <div class="center_align"> <a data-open="characterization_image_8" href="#"> <img class="characterization_image image-characterization" data-full-sized-image="characterization_image_8" data-full-sized-image-path="/file/view/antibody_original/cdff0b38e2f2a327a806898a0cc0bf06" height="233" width="255" alt="Click to enlarge image Indirect ELISA (ie, binding of Antibody to Antigen coated plate). Note: B50% represents the concentration of Ab required to generate 50% of maximum binding." src="/file/view/antibody/188d97ca1e6b336af8fcece1e9d21d50" data-width="500" /> </a> <span>Click image to enlarge</span> </div> <div id="characterization_image_8" class="reveal" style="width: 500px;" data-reveal aria-labelledby="firstModalTitle" aria-hidden="true" role="dialog"> <div class="close-characterization-image" title="Click to close the IHC Cell Line Reference Image"> <a class="close-reveal-modal" aria-label="Close" href="#">×</a> </div> <img alt="Indirect ELISA (ie, binding of Antibody to Antigen coated plate). Note: B50% represents the concentration of Ab required to generate 50% of maximum binding." src="" /> </div> <h3 class="detail-type-header align-left">CPTC-CPE-3 Indirect ELISA</h3> <div><p>Result: <strong>Positive</strong></p></div> <p class="detail-type-text">Indirect ELISA (ie, binding of Antibody to Antigen coated plate). Note: B50% represents the concentration of Ab required to generate 50% of maximum binding.</p><br /> <div class="download-file-container"> <div class="antibody-char-sop-box"> <h3 class="detail-type-header">Characterization SOP Files</h3> <ul class="sop-file-list"> <li> <img style="border: 0px;" align="absmiddle" alt="Download file document type" src="/resources/images/site/application_pdf.gif" />  <a title="Download Evaluation using Indirect ELISA (250.5 KB)" href="/file/download/characterization_image_sop/e4795ed47b3aef0a402939ebbe36f0a1">Evaluation using Indirect ELISA (250.5 KB)</a></li> </ul></div> </div> </div> </div> <div class="image-container"> <a href="#" class="characterization_toggle closed" data-char-toggle="characterization_9"> <h6><i class="fa fa-plus characterization_9" aria-hidden="true"></i>  Western Blot - Recombinant Protein or Peptide</h6> </a> <div class="characterization_container" id="characterization_9"> <div class="center_align"> <a data-open="characterization_image_9" href="#"> <img class="characterization_image image-characterization" data-full-sized-image="characterization_image_9" data-full-sized-image-path="/file/view/antibody_original/b9d112bad25c9d58a84da49880364131" height="255" width="106" alt="Click to enlarge image Western blot of CPTC-CPE-3 antibody with full length CPE recombinant protein (NCI ID#00236)." src="/file/view/antibody/f6cd6df3441d4b1aadb5f7ba340a6933" data-width="177" /> </a> <span>Click image to enlarge</span> </div> <div id="characterization_image_9" class="reveal" style="width: 177px;" data-reveal aria-labelledby="firstModalTitle" aria-hidden="true" role="dialog"> <div class="close-characterization-image" title="Click to close the IHC Cell Line Reference Image"> <a class="close-reveal-modal" aria-label="Close" href="#">×</a> </div> <img alt="Western blot of CPTC-CPE-3 antibody with full length CPE recombinant protein (NCI ID#00236)." src="" /> </div> <h3 class="detail-type-header align-left">CPTC-CPE-3 Western blot</h3> <div><p>Result: <strong>Positive</strong></p></div> <p class="detail-type-text">Western blot of CPTC-CPE-3 antibody with full length CPE recombinant protein (NCI ID#00236).</p><br /> <div class="download-file-container"> <div class="antibody-char-sop-box"> <h3 class="detail-type-header">Characterization SOP Files</h3> <ul class="sop-file-list"> <li> <img style="border: 0px;" align="absmiddle" alt="Download file document type" src="/resources/images/site/application_pdf.gif" />  <a title="Download Evaluation using Western Blot (108.9 KB)" href="/file/download/characterization_image_sop/b367b4a842bf659e980a30556dc349b3">Evaluation using Western Blot (108.9 KB)</a></li> </ul></div> </div> </div> </div> </div> <div class="top-link"><a title="Back to top of page" href="#top">[top]</a></div> <a name="CPTC-CPE-3-SOPs"></a> <div class="clear"></div> </div> </div> <a name="Carboxypeptidase_E_(mouse)"></a> <div class="well"> <div class="detail-type-header"> <a title="hide/show details" class="manageMenuBlock-link" href="javascript:void(0)" onclick="showDataBlock('block-antigen',true)"> <h4><i class="fa fa-minus icon-block-antigen" aria-hidden="true"></i>Antigen: Carboxypeptidase E (mouse)</h4> </a> </div> <div id="antigen-menu-down" title="Click to display Antigen data" class="block_record_menu_down_icon" onclick="manageMenuBlock('top-antigen'); showDataBlock('block-antigen',false)"> </div> <div class="block_record" id="block-antigen"> <a name="Carboxypeptidase E (mouse)-Background"></a> <h5 class="nopadding">Background</h5> <p> <div class="detail-label"><p>NCI Identification Number:</p></div> <div class="detail-value"><p>00236</p></div> <div class="clear"></div> <div class="detail-label"><p>Antigen Name:</p></div> <div class="detail-value"><p>Carboxypeptidase E (mouse)</p></div> <div class="clear"></div> <div class="detail-label"><p>CPTC Name:</p></div> <div class="detail-value"><p>CPTC-CPE</p></div> <div class="clear"></div> <div class="detail-label"><p>Aliases:</p></div> <div class="detail-value"><p>Carboxypeptidase E; Enkephalin Convertase; Carboxypeptidase H; Cobalt-Stimulated Chromaffin Granule Carboxypeptidase; Insulin Granule-Associated Carboxypeptidase; Prohormone-Processing Carboxypeptidase; EC 3.4.17.10; CPH; EC 3.4.17</p></div> <div class="clear"></div> <div class="detail-label"><p>Function:</p></div> <div class="detail-value"><p>This gene encodes a member of the M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. This protein may also function independently of its peptidase activity, as a neurotrophic factor that promotes neuronal survival, and as a sorting receptor that binds to regulated secretory pathway proteins, including prohormones. Mutations in this gene are implicated in type 2 diabetes. <br /> <br /> CPE (Carboxypeptidase E) is a Protein Coding gene. Diseases associated with CPE include Hyperproinsulinemia and Phlebotomus Fever. Among its related pathways are Allograft rejection and Peptide hormone metabolism. GO annotations related to this gene include cell adhesion molecule binding and carboxypeptidase activity. An important paralog of this gene is CPD.<br /> <br /> Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin.</p></div> <div class="clear"></div> <div class="detail-label"><p>Chromosomal Localization:</p></div> <div class="detail-value"><p>4q32.3</p></div> <div class="clear"></div> <div class="detail-label"><p>Expression System:</p></div> <div class="detail-value"><p>Baculovirus</p></div> <div class="clear"></div> <div class="detail-label"><p>Accession Number:</p></div> <div class="detail-value"><p>NP_038522.2</p></div> <div class="clear"></div> <div class="detail-label"><p>UniProt Accession Number:</p></div> <div class="detail-value"><p>Q00493</p></div> <div class="clear"></div> <div class="detail-label"><p>DNA Source:</p></div> <div class="detail-value"><p>N/A</p></div> <div class="clear"></div> <div class="detail-label"><p>Immunogen:</p></div> <div class="detail-value"><p>Recombinant Full Length Protein</p></div> <div class="clear"></div> <div class="detail-label"><p>Vector Name:</p></div> <div class="detail-value"><p>Not provided</p></div> <div class="clear"></div> <div class="detail-label"><p>Extinction Coefficient:</p></div> <div class="detail-value"><p></p></div> <div class="clear"></div> <div class="detail-label"><p>Buffers:</p></div> <div class="detail-value"><p>PBS, pH 7.2</p></div> <div class="clear"></div> <div class="detail-label sequence"><p>Expressed Sequence:</p></div> <div class="detail-value sequence"> <p><span class="format-sequence">MAGRGGRVLLALCAALVAGGWLLTAEAQEPGAPAAGMRRRRRLQQEDGIS<br />FEYHRYPELREALVSVWLQCTAISRIYTVGRSFEGRELLVIELSDNPGVH<br />EPGEPEFKYIGNMHGNEAVGRELLIFLAQYLCNEYQKGNETIVNLIHSTR<br />IHIMPSLNPDGFEKAASQPGELKDWFVGRSNAQGIDLNRNFPDLDRIVYV<br />NEKEGGPNNHLLKNLKKIVDQNSKLAPETKAVIHWIMDIPFVLSANLHGG<br />DLVANYPYDETRSGTAHEYSSCPDDAIFQSLARAYSSFNPVMSDPNRPPC<br />RKNDDDSSFVDGTTNGGAWYSVPGGMQDFNYLSSNCFEITVELSCEKFPP<br />EETLKSYWEDNKNSLISYLEQIHRGVKGFVRDLQGNPIANATISVDGIDH<br />DVTSAKDGDYWRLLAPGNYKLTASAPGYLAITKKVAVPFSPAVGVDFELE<br />SFSERKEEEKEELMEWWKMMSETLNFHHHHHH</span></p></div> <div class="clear"></div> <div class="detail-label sequence"><p>Native Sequence:</p></div> <div class="detail-value sequence"><p><span class="format-sequence"></span></p></div> <div class="clear"></div> <div class="detail-label"><p>Calculated Isoelectric Point:</p></div> <div class="detail-value"><p>0</p></div> <div class="clear"></div> <div class="detail-label"><p>Molecular Weight:</p></div> <div class="detail-value"><p>53000</p></div> <div class="clear"></div> <div class="detail-label"><p>Last Updated:</p></div> <div class="detail-value"><p>06/18/2020</p></div> <div class="clear"></div> </p> <a name="Carboxypeptidase E (mouse)-Links"></a> <h3>Links</h3> <p> <ul class="antigen-url-list"> <li> <strong> EnsEMBL </strong> - <a title="View EnsEMBL link in new window" href="http://useast.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000109472;r=4:165361194-165498547" target="_blank">EnsEMBL CPE</a> </li> <li> <strong> Entrez </strong> - <a title="View Entrez link in new window" href="https://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=full_report&list_uids=1363" target="_blank">Entrez CPE</a> </li> <li> <strong> Uniprot </strong> - <a title="View link in new window" href="https://www.uniprot.org/uniprot/Q00493" target="_blank">Uniprot Q00493</a> </li> </ul> </p> <a name="Carboxypeptidase E (mouse)-Characterization"></a> <h5>Characterization Data</h5> <a name="Carboxypeptidase E (mouse)-SOPs"></a> <h3>SOPs</h3> <div class="download-file-container"> <p>No SOPs available.</p> <div class="top-link"><a title="Back to top of page" href="#top">[top]</a></div> </div> </div> </div> <div class="clear"></div> <div id="compareModal" class="reveal" data-reveal aria-labelledby="Compare Antibody Details" aria-hidden="true" role="dialog"> <div id="antibody_compare_details"></div> </div> <input id="mouseX" type="hidden" value="0" /> <input id="mouseY" type="hidden" value="0" /> <div id="compare-original-images"></div>  </div> </div> </div>  <div id="adobe-required"> <h3>Don't have Adobe Reader™? 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The Clinical Proteomic Technologies for Cancer | Details for CPTC-CPE-1