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The program also performs irradiations for non-isotope applications, sells by-products, and explores opportunities for new products and radioisotope applications. </p> <p class="font-plus-2">The <a href="blip.php" target="_blank">Brookhaven Linac Isotope Producer</a> (BLIP) consists of a beam line and target area for isotope production that uses protons up to 200 MeV energy and 165 µA intensity from Brookhaven's Linac. Since the Linac primarily serves as an injector to higher energy synchrotrons, BLIP generally operates parasitically with the Brookhaven nuclear physics program although some independent running of BLIP takes place to extend operations when necessary.</p> <div class="grid_12 alpha"> <img class="fwd" alt="photo of linear accelerator" src="images/linac-tunnel.jpg"/> </div> <div class="grid_12 omega"> <img class="fwd" alt="photo of target preparation" src="images/target-preparation.jpg"/> </div> <p class="caption">At left, the linear accelerator (linac) that supplies beam to BLIP targets. At right, a technician prepares targets for irradition.</p> <h2>Radioisotope Production </h2> <p>The Brookhaven Isotope Program is capable of producing a variety radioisotopes. See the link to the full catalog below. Some isotopes not scheduled for production at Brookhaven Lab may be available from other Department of Energy laboratories. The research offerings are subject to a DOE review process and may not be available every year. Rental of hot cell space as well as irradiations not requiring chemical separation are also possible. Lengthy irradiations for physics experiments can be accommodated if compatible with our ongoing radioisotope production.</p> <div class="accordion"> <h3>Available Isotopes / Ordering</h3> <div> <h4>α-Emitter Updates</h4> <p><strong>Actinium-225</strong> - The DOE IP has historically used a thorium-229 cow to provide actinium-225 and its bismuth-213 daughter. This product is distributed weekly to various groups for R&D and early-stage clinical trials. However, the limited supplies of this material are insufficient to support multiple advanced-stage clinical trials. The Ac-225 Tri-Lab Effort between BNL, LANL, and ORNL has made substantial progress toward increasing production capacity over 100-fold via accelerator-based production. New production and processing methods as well as planned facility upgrades will enable further applications of Ac-225 and Bi-213 to a broader scope of researchers and patient populations. A Drug Master File (DMF) was recently filed on the accelerator-produced Ac-225 product, and a DMF is scheduled to be completed in FY 2021 for the Th-229 cow product. Accelerator-produced Ac-225 samples have been evaluated by the community in dosimetry and toxicology studies, some of which were recently presented and discussed in a virtual forum at the annual Ac-225 User Group meeting. Accelerator-produced Ac-225 is routinely available on an approximately 6-week basis.</p> <h4>Newly Available Isotopes</h4> <p><strong>Copper-67</strong>—The capability to produce Cu-67 has been developed at both Argonne National Laboratory (ANL) and BNL. ANL routinely produces 2 Ci batches of high-specific activity (400 Ci/mg at end of batch) material by phototransmutation using an electron linac. BNL provides lower specific activity material (20 Ci/mg) using a proton linac. </p> <h4>Isotopes Under Development</h4> <p><strong>Selenium-72</strong> —generator (PET imaging agent)—under development </p> <h4>Other Routinely Available Medically Relevant Isotopes </h4> <p><strong>Yttrium-86</strong> —PET imaging agent and theranostic pair to Y-90—available. BNL is working on a <a href="https://www.isotopes.gov/node/215">new batch of Y-86</a>. <br><strong>Zinc-65</strong></p> <p>For more information on the availability of isotopes, quotes and orders, please contact the National Isotope Development Center (NIDC) at <a href="mailto:contact@isotopes.gov"> contact@isotopes.gov</a>.</p> <p>Quotes can be obtained, and orders are placed through the <a target="_blank" href="https://www.isotopes.gov/">National Isotope Development Center</a>.</p> <p>For technical information on BNL produced isotopes, please contact: <br>Dr. Cathy Sue Cutler, Isotope Program Director<br> (631) 344-3873 | <a href="mailto:ccutler@bnl.gov">ccutler@bnl.gov</a></p> </div> </div> <div class="boxed"> <h5 class="center">For technical information on isotope products: </h5> <p class="center"><a class="button reversed" href="https://www.isotopes.gov/">Contact the National Isotope Development Center</a></p> <p class="font-1">The National Isotope Development Center</a> (NIDC) is funded by the U.S. Department of Energy Isotope Program. It serves as an interface with the user community and manages the coordination of isotope production across the program facilities at Argonne, Brookhaven, Idaho, Los Alamos, Oak Ridge, and Pacific Northwest National Laboratories. These facilities produce stable and radioactive isotopes in short supply using reactors, accelerators, and other methods.</p> </div> <h3>Mission and Funding</h3> <p>The Brookhaven National Laboratory Isotope Research and Production Department receives funding from the U.S. Department of Energy Isotope R&D and Production Program (DOE Isotope Program), managed by the Office of Science, as part of a suite of national laboratories and universities focused on isotope R&D and production. The mission of the DOE Isotope Program is to produce and distribute stable and radioactive isotopes for research and applications that are in short supply and critical to the prosperity and security of the Nation. The DOE Isotope Program supports isotope production, R&D on isotope production techniques, workforce development, and reduction of U.S. dependency on foreign supply chains. Those interested in purchasing stable or radioactive isotopes from the DOE Isotope Program should contact the <a target="_blank" href="https://www.isotopes.gov/">National Isotope Development Center</a>.</p> </div> <div class="grid_8"> <a target="_blank" href="https://science.osti.gov/Isotope-Research-Development-and-Production"> <img class="fwd" title="DOE Isotope Program" style="display:block; margin:0em auto 3em auto;width:80%" alt="DOE isotopes program logo" src="images/isotopes-program-logo.png"/> </a> <div class="tabs"> <ul> <li><a href="#tabs-1">Staff</a></li> <li><a href="#tabs-2">Support</a></li> <li><a href="#tabs-3">Administrative</a></li> </ul> <div id="tabs-1"> <ul class='staffBioCards cardType4 images'> <li ln='25604'> <div class='imageContainer'><img alt='Cathy Cutler' src='https://www.bnl.gov/staff/pics/square/25604.jpg' onerror='this.onerror=null;this.src="https://www.bnl.gov/staff/pics/square/no-photo.jpg";' ></div><div class='textContainer'><a title='Full Bio' href='https://www.bnl.gov/staff/ccutler'><h5>Cathy Cutler</h5></a> <p class='jobTitle'>Chair, Isotope Research and Production Department</p> <p class='contactInfo'><span class='phone'>(631) 344-3873</span>, <span class='email'><a href='mailto:ccutler@bnl.gov'>ccutler@bnl.gov</a></span></p> </div><li ln='23641'> <div class='imageContainer'><img alt='Jasmine Hatcher-Lamarre' src='https://www.bnl.gov/staff/pics/square/23641.jpg' onerror='this.onerror=null;this.src="https://www.bnl.gov/staff/pics/square/no-photo.jpg";' ></div><div class='textContainer'><a title='Full Bio' href='https://www.bnl.gov/staff/jhatcherlamarre'><h5>Jasmine Hatcher-Lamarre</h5></a> <p class='contactInfo'><span class='phone'>(631) 344-8257</span>, <span class='email'><a href='mailto:JHatcherLamarre@bnl.gov'>JHatcherLamarre@bnl.gov</a></span></p> </div><li ln='24921'> <div class='imageContainer'><img alt='Dohyun Kim' src='https://www.bnl.gov/staff/pics/square/24921.jpg' onerror='this.onerror=null;this.src="https://www.bnl.gov/staff/pics/square/no-photo.jpg";' ></div><div class='textContainer'><a title='Full Bio' href='https://www.bnl.gov/staff/dohkim'><h5>Dohyun Kim</h5></a> <p class='contactInfo'><span class='phone'>(631) 344-7850</span>, <span class='email'><a href='mailto:dohkim@bnl.gov'>dohkim@bnl.gov</a></span></p> </div><li ln='23423'> <div class='imageContainer'><img alt='Dmitri Medvedev' src='https://www.bnl.gov/staff/pics/square/23423.jpg' onerror='this.onerror=null;this.src="https://www.bnl.gov/staff/pics/square/no-photo.jpg";' ></div><div class='textContainer'><a title='Full Bio' href='https://www.bnl.gov/staff/dmedvede'><h5>Dmitri Medvedev</h5></a> <p class='contactInfo'><span class='phone'>(631) 344-3578</span>, <span class='email'><a href='mailto:dmedvede@bnl.gov'>dmedvede@bnl.gov</a></span></p> </div><li ln='20384'> <div class='imageContainer'><img alt='Lisa Muench' src='https://www.bnl.gov/staff/pics/square/20384.jpg' onerror='this.onerror=null;this.src="https://www.bnl.gov/staff/pics/square/no-photo.jpg";' ></div><div class='textContainer'><a title='Full Bio' href='https://www.bnl.gov/staff/muench'><h5>Lisa Muench</h5></a> <p class='contactInfo'><span class='phone'>(631) 344-8055</span>, <span class='email'><a href='mailto:muench@bnl.gov'>muench@bnl.gov</a></span></p> </div><li ln='25919'> <div class='imageContainer'><img alt='Vanessa Sanders' src='https://www.bnl.gov/staff/pics/square/25919.jpg' onerror='this.onerror=null;this.src="https://www.bnl.gov/staff/pics/square/no-photo.jpg";' ></div><div class='textContainer'><a title='Full Bio' href='https://www.bnl.gov/staff/vsanders'><h5>Vanessa Sanders</h5></a> <p class='jobTitle'>Associate Scientist</p> <p class='contactInfo'><span class='phone'>(631) 344-7230</span>, <span class='email'><a href='mailto:vsanders@bnl.gov'>vsanders@bnl.gov</a></span></p> </div><li ln='26800'> <div class='imageContainer'><img alt='Christopher Vitkun' src='https://www.bnl.gov/staff/pics/square/26800.jpg' onerror='this.onerror=null;this.src="https://www.bnl.gov/staff/pics/square/no-photo.jpg";' ></div><div class='textContainer'><a title='Full Bio' href='https://www.bnl.gov/staff/cvitkun'><h5>Christopher Vitkun</h5></a> <p class='contactInfo'><span class='phone'>(631) 344-8727</span>, <span class='email'><a href='mailto:cvitkun@bnl.gov'>cvitkun@bnl.gov</a></span></p> </div></ul> </div> <div id="tabs-2"> <ul class='staffBioCards cardType4 images'> <li ln='17382'> <div class='imageContainer'><img alt='Mark Davis' src='https://www.bnl.gov/staff/pics/square/17382.jpg' onerror='this.onerror=null;this.src="https://www.bnl.gov/staff/pics/square/no-photo.jpg";' ></div><div class='textContainer'><a title='Full Bio' href='https://www.bnl.gov/staff/mdavis'><h5>Mark Davis</h5></a> <p class='groupName'>Staff</p> <p class='contactInfo'><span class='phone'>(631) 344-2165</span>, <span class='email'><a href='mailto:mdavis@bnl.gov'>mdavis@bnl.gov</a></span></p> </div></ul> </div> <div id="tabs-3"> <ul class='staffBioCards cardType4 images'> <li ln='27025'> <div class='imageContainer'><img alt='Courtney Davidson' src='https://www.bnl.gov/staff/pics/square/27025.jpg' onerror='this.onerror=null;this.src="https://www.bnl.gov/staff/pics/square/no-photo.jpg";' ></div><div class='textContainer'><a title='Full Bio' href='https://www.bnl.gov/staff/cdavidson'><h5>Courtney Davidson</h5></a> <p class='contactInfo'><span class='phone'>(631) 344-3175</span>, <span class='email'><a href='mailto:cdavidson@bnl.gov'>cdavidson@bnl.gov</a></span></p> </div></ul> </div> </div> <ul class='articleSummaries alt1'> <li class=''><a target='_top' href='https://www.bnl.gov/newsroom/news.php?a=221690'><div class='thumbnail'><img onerror='this.src="/assets/global/images/unavailable-minipic.jpg";' src='/today/intra_pics/2024/03/2023-03-17-398-0001-234px.jpg' alt='long-exposure image' /></div> <h3>Brookhaven Lab Staff Receive Secretary of Energy Achievement Awards</h3> </a> <div class='clear'></div> <li class=''><a target='_top' href='https://www.bnl.gov/newsroom/news.php?a=121539'><div class='thumbnail'><img onerror='this.src="/assets/global/images/unavailable-minipic.jpg";' src='/today/intra_pics/2023/10/d2200617-234px.jpg' alt='Cathy Cutler' /></div> <h3>Cathy Sue Cutler Named Chair of Isotope Research and Production Department</h3> </a> <div class='clear'></div> <li class=''><a target='_top' href='https://www.bnl.gov/newsroom/news.php?a=221512'><div class='thumbnail'><img onerror='this.src="/assets/global/images/unavailable-minipic.jpg";' src='/today/intra_pics/2023/10/nidc-listservgraphic_original-234px.jpg' alt='Vanessa Sanders' /></div> <h3>Increasing Access to Radioisotopes by Advancing Radiochemical Training Capabilities</h3> </a> <div class='clear'></div> <li class=''><a target='_top' href='https://www.bnl.gov/newsroom/news.php?a=221204'><div class='thumbnail'><img onerror='this.src="/assets/global/images/unavailable-minipic.jpg";' src='/today/intra_pics/2023/04/2023-03-13-398-0029-234px.jpg' alt='An MIRP researcher, wearing glasses and a white lab coat, looks a hot-cell window that has a yellow' /></div> <h3>Promising Medical Isotope Made <em>and Processed</em> at Brookhaven Lab</h3> </a> <div class='clear'></div> </ul> </div>  </div> </div> <div id="topOfPage"><span class="fa fa-chevron-circle-up fa-lg topOfPageTrigger"></span></div> <div class="footer" id="footer" > <div class="container_24"> <div class="grid_6"> <h3 id="BNL">Brookhaven National Laboratory</h3> <p>PO Box 5000<br/> Upton, NY 11973-5000<br/> (631) 344-8000</p> <p><a id="contactUs" class="extrasmall white button" href="https://www.bnl.gov/contact-us/">Contact us</a></p> <ul class="socialMediaIcons"> <li><a target="_blank" href="https://twitter.com/BrookhavenLab" title="Follow Us on 𝕏"><i class="fa-brands fa-square-x-twitter fa-2x"></i></a> <li><a target="_blank" 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