Immuno-oncology Research Area

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class="system_main_block"> <article> <div> <div> <div> <div class="paragraph paragraph--type--_-1-text-to-media mb-4 paragraph--view-mode--default p-3"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--75-25"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:3_1_text_to_media:field_header_2_global"> <div><br><br><h2>Immuno-Oncology Research - From Bench to Bedside</h2></div> </div> <div class="field_block:paragraph:3_1_text_to_media:field_lg_sngl_frmtd_text_global"> <div><p>Immuno-oncology research is helping to advance cancer therapy. 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Easily find the antibody that you need to detect lineage, activation, and exhaustion markers with our wide selection of unlabeled and fluorochrome-conjugated antibodies.</p></div> </div> <div class="card-bottom-link"> <div> <a href="/methods/flow-cytometry" > Flow Cytometry </a> </div> </div> </div> </div> </div> <div class="col-md-4"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="/applications/immuno-oncology-immunoassays" > <div class="card-img-top text-center mb-3" style="background-repeat: no-repeat; background-color: #f5f5f5; height:200px; width: 100%;"> <div class="teaser-valign-container" style=""> <div class="valign"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/simple-plex-ella-aav.png" alt="Ella, the benchtop automated ELISA platform for Simple Plex assays" loading="lazy" > </div> </div> </div> </a> <a class="card_title_link" href="/applications/immuno-oncology-immunoassays" > <h3 class="card_title_htag"> <div><h3>Expedite with Analytical Instruments</h3></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>With Luminex<sup>®</sup> multiplexing, automated Ella, Simple Western assays and ready-to-use Quantikine ELISAs—we're here to expedite your biomarker discovery.</p></div> </div> <div class="card-bottom-link"> <div> <a href="/applications/immuno-oncology-immunoassays" > Immunoassays </a> </div> </div> </div> </div> </div> <div class="col-md-4"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="/reagents/rnascope-ish-technology" > <div class="teaser-card-image-crop mb-3"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/webinars/visualization-and-analysis-of-rnascope-results-using-qupath-webinar-500x325.jpg" alt="Visualization and analysis of RNAscope results using QuPath webinar" loading="lazy" > </div> </a> <a class="card_title_link" href="/reagents/rnascope-ish-technology" > <h3 class="card_title_htag"> <div><h3>Visualize with RNAscope™ ISH</h3></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>Visualize cell-cell interactions, identify immune cell sub-populations secreting pro and anti-inflammatory cytokines, or check the efficacy of your immune checkpoint therapeutics. Our innovative RNAscope™ ISH Technology enables the simultaneous detection of RNA and protein while keeping the tumor tissue architecture intact.</p></div> </div> <div class="card-bottom-link"> <div> <a href="/reagents/rnascope-ish-technology" > RNAscope ISH </a> </div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><h2><a name="checkpoint-marker-assessment"></a>Checkpoint Marker Assessment</h2></div> </div> </div> <div> <div class="paragraph paragraph--type--card-paragraph paragraph--view-mode--default card-para-default"> <div class="row card_row"> <div class="col-md-4"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="/reagents/proteins/immune-checkpoint-proteins" > <div class="teaser-card-image-crop mb-3"> <img loading="lazy" class="card-background-image card-img-top" src="https://resources.bio-techne.com/bio-techne-assets/images/banners/black-blue-gradient-525x315.png" /> </div> <div class="card-foreground-image"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/immuno-oncology-hero-solo.png" alt="Immuno-oncology" loading="lazy" > </div> </a> <a class="card_title_link" href="/reagents/proteins/immune-checkpoint-proteins" > <h3 class="card_title_htag"> <div><h3>Identify with Immune Checkpoint Proteins</h3></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>Develop a highly sensitive inhibitor screening assay and confirm the activity of your most promising candidates with our immune checkpoint proteins and blocking/neutralization antibodies. Our products provide the performance and consistency needed to advance your drug discovery research.</p></div> </div> <div class="card-bottom-link"> <div> <a href="/reagents/proteins/immune-checkpoint-proteins" > Immune Checkpoint Proteins </a> </div> </div> </div> </div> </div> <div class="col-md-4"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="/reagents/elisa-kits/immune-checkpoint-assays" > <div class="card-img-top text-center mb-3" style="background-repeat: no-repeat; background-color: #f5f5f5; height:200px; width: 100%;"> <div class="teaser-valign-container" style=""> <div class="valign"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/vaccine-lp-jess-v2.png" alt="ProteinSimple instrument Jess - automated simple western" loading="lazy" > </div> </div> </div> </a> <a class="card_title_link" href="/reagents/elisa-kits/immune-checkpoint-assays" > <h3 class="card_title_htag"> <div><h3>Specify with Analytical Platforms</h3></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>Check your checkpoint with specificity and sensitivity–whether it’s PD-L1, CTLA-4 or another promising molecule, we offer immunoassay platforms for all your specificity needs. From plate based ELISAs, to multiplex options with Luminex, to our fully automated Simple Plex and Simple Western platforms -- our solutions ensure that you get accurate and consistent results in minimal time.</p></div> </div> <div class="card-bottom-link"> <div> <a href="/reagents/elisa-kits/immune-checkpoint-assays" > Immune Checkpoint Instrumentation </a> </div> </div> </div> </div> </div> <div class="col-md-4"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="/applications/spatial-biology/rnascope-cancer" > <div class="teaser-card-image-crop mb-3"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/therapeutic-manufacturing/human-breast-cancer-il21r-manual-rnascope-2.5-brown.jpg" alt=" Detection of IL21R in human breast cancer using RNAscope 2.5 HD Brown Assay" loading="lazy" > </div> </a> <a class="card_title_link" href="/applications/spatial-biology/rnascope-cancer" > <h3 class="card_title_htag"> <div><h3>Detect with Spatial Assays</h3></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>Rapidly detect the inter- and intratumor heterogeneity of checkpoint marker expression in situ with RNAscope ISH assays, and Multiplex, Duplex (R&D Systems) and HiPlex assays – the most sensitive, single cell spatial-platforms to assess checkpoint marker gene expression.</p></div> </div> <div class="card-bottom-link"> <div> <a href="/applications/spatial-biology/rnascope-cancer" > Spatial Immuno-Oncology Solutions </a> </div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><h2><a name="immune-cell-culture"></a>Investigating Immune Cells</h2></div> </div> </div> <div> <div class="paragraph paragraph--type--card-paragraph paragraph--view-mode--default card-para-default"> <div class="row card_row"> <div class="col-md-4"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="/instruments/single-cell-dispensers" > <div class="card-img-top text-center mb-3" style="background-repeat: no-repeat; background-color: #f5f5f5; height:200px; width: 100%;"> <div class="teaser-valign-container" style=""> <div class="valign"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/io-research-lp_immune-checkpoints-thumb.png" alt="Tools for Investigating Immune Checkpoint Targets Product Guide" loading="lazy" > </div> </div> </div> </a> <a class="card_title_link" href="/instruments/single-cell-dispensers" > <h3 class="card_title_htag"> <div><h3>Select and Isolate with Pala</h3></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>Traditional cell sorting methods have their challenges when your work calls for simplicity, flexibility, and accessibility. Whether you are cloning transfected single cells, isolating a specific population, or finding rare cancer cells, the compact and incredibly simple to Pala single cell dispenser allows you to gently sort single cells or target cell populations in any lab.</p></div> </div> <div class="card-bottom-link"> <div> <a href="/instruments/single-cell-dispensers" > Meet Pala </a> </div> </div> </div> </div> </div> <div class="col-md-4"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="/reagents/proteins/immune-cell-culture-proteins" > <div class="card-img-top text-center mb-3" style="background-repeat: no-repeat; background-color: #f5f5f5; height:200px; width: 100%;"> <div class="teaser-valign-container" style=""> <div class="valign"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/io-research-lp_select.png" alt="Select Icon" loading="lazy" > </div> </div> </div> </a> <a class="card_title_link" href="/reagents/proteins/immune-cell-culture-proteins" > <h3 class="card_title_htag"> <div><h3>Expand and Differentiate with Proteins</h3></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>Achieve robust, reproducible immune cell cultures with R&D Systems<sup>TM</sup> proteins. Our proteins are rigorously tested to ensure that they will provide superior performance and lot-to-lot consistency, so you can have confidence in their ability to promote optimal immune cell expansion and differentiation.</p></div> </div> <div class="card-bottom-link"> <div> <a href="/reagents/proteins/immune-cell-culture-proteins" > Explore Proteins for Immune Cell Culture </a> </div> </div> </div> </div> </div> <div class="col-md-4"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="/research-areas/immunology/immune-response-analysis" > <div class="card-img-top text-center mb-3" style="background-repeat: no-repeat; background-color: #f5f5f5; height:200px; width: 100%;"> <div class="teaser-valign-container" style=""> <div class="valign"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/io-research-lp_expand.png" alt="Expand Icon" loading="lazy" > </div> </div> </div> </a> <a class="card_title_link" href="/research-areas/immunology/immune-response-analysis" > <h3 class="card_title_htag"> <div><h3>Characterize with Analytical Systems</h3></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>Characterize immune cell types with highly sensitivity analytical tools. 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