In Review | SpringerNature | Publish your research

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data-track-component="teaser-navigation-full - Policies - /la/policies">Policies</a> </div> </div></div></li><li class="collection-navigation-header-level-3--listwrap" id=""><div id="c12211730" class="teaser-navigation-full--style-theme-orange teaser teaser-navigation-full item-8 item-8-18"><div> <div class="core"> <a href="/la/librarians" class="link" data-track="click" data-track-label="/la/authors/campaigns/in-review" data-track-category="sn:content-page-mainnav" data-track-component="teaser-navigation-full - Librarians - /la/librarians">Librarians</a> </div> </div></div></li><li class="collection-navigation-header-level-3--listwrap" id=""><div id="c19250658" class="teaser-navigation-full--style-theme-green teaser teaser-navigation-full item-9 item-9-18"><div> <div class="core"> <a href="/la/booksellers" class="link" data-track="click" data-track-label="/la/authors/campaigns/in-review" data-track-category="sn:content-page-mainnav" data-track-component="teaser-navigation-full - Booksellers - /la/booksellers">Booksellers</a> </div> </div></div></li><li class="collection-navigation-header-level-3--listwrap" id=""><div id="c12147376" class="teaser-navigation-full--style-theme-lilac teaser teaser-navigation-full item-10 item-10-18"><div> <div class="core"> <a href="/la/societies" class="link" data-track="click" data-track-label="/la/authors/campaigns/in-review" data-track-category="sn:content-page-mainnav" data-track-component="teaser-navigation-full - Societies - /la/societies">Societies</a> </div> </div></div></li><li class="collection-navigation-header-level-3--listwrap" id=""><div id="c12147382" class="teaser-navigation-full--style-theme-lime teaser teaser-navigation-full item-11 item-11-18"><div> <div class="core"> <a href="/la/partners" class="link" data-track="click" data-track-label="/la/authors/campaigns/in-review" data-track-category="sn:content-page-mainnav" data-track-component="teaser-navigation-full - Partners - /la/partners">Partners</a> </div> </div></div></li><li class="collection-navigation-header-level-3--listwrap" id=""><div id="c12147378" class="teaser-navigation-full--style-theme-neutral teaser teaser-navigation-full item-12 item-12-18"><div> <div class="core"> <a href="/la/shop" class="link" data-track="click" data-track-label="/la/authors/campaigns/in-review" data-track-category="sn:content-page-mainnav" data-track-component="teaser-navigation-full - Shop - /la/shop">Shop</a> </div> </div></div></li><li class="collection-navigation-header-level-3--listwrap" id=""><div id="c12279240" class="teaser-navigation-full--style-theme-blue teaser teaser-navigation-full item-13 item-13-18"><div> <div class="core"> <a href="/la/advancing-discovery" class="link" data-track="click" data-track-label="/la/authors/campaigns/in-review" data-track-category="sn:content-page-mainnav" data-track-component="teaser-navigation-full - What we do - /la/advancing-discovery">What we do</a> </div> </div></div></li><li class="collection-navigation-header-level-3--listwrap" id=""><div id="c12147360" class="teaser-navigation-full--style-theme-neutral teaser teaser-navigation-full item-14 item-14-18"><div> <div class="core"> <a href="/la/contact" class="link" data-track="click" data-track-label="/la/authors/campaigns/in-review" data-track-category="sn:content-page-mainnav" data-track-component="teaser-navigation-full - Contact - /la/contact">Contact</a> </div> </div></div></li><li class="collection-navigation-header-level-3--listwrap" id=""><div id="c27718490" class="teaser teaser-navigation-full item-15 item-15-18"><div> <div class="core"> <div class="richtext richtext-default"><p>-------</p></div> </div> </div></div></li><li class="collection-navigation-header-level-3--listwrap" id=""><div id="c12270944" class="teaser-navigation-full--style-theme-blue teaser teaser-navigation-full item-16 item-16-18"><div> <div class="core"> <a href="/la/group" class="link" data-track="click" data-track-label="/la/authors/campaigns/in-review" data-track-category="sn:content-page-mainnav" data-track-component="teaser-navigation-full - Corporate Site ↗ - /la/group">Corporate Site ↗</a> </div> </div></div></li><li class="collection-navigation-header-level-3--listwrap" id=""><div id="c27718494" class="teaser-navigation-full--style-theme-blue teaser teaser-navigation-full item-17 item-17-18"><div> <div class="core"> <a href="/la/group/media" class="link" data-track="click" data-track-label="/la/authors/campaigns/in-review" data-track-category="sn:content-page-mainnav" data-track-component="teaser-navigation-full - Media Centre ↗ - /la/group/media">Media Centre ↗</a> </div> </div></div></li><li class="collection-navigation-header-level-3--listwrap" id=""><div id="c14237826" class="teaser-navigation-full--style-theme-blue teaser teaser-navigation-full item-18 item-18-18 last-item end"><div> <div class="core"> <a href="/la/group/careers" class="link" data-track="click" data-track-label="/la/authors/campaigns/in-review" data-track-category="sn:content-page-mainnav" data-track-component="teaser-navigation-full - Careers ↗ - /la/group/careers">Careers ↗</a> </div> </div></div></li></ul> </div> </div></div></li></ul> </div> </div> </div></div></li><li class="collection-navigation-header--listwrap column" id=""><div id="c25958676" class="teaser teaser-navigation item-2 item-2-4"><div> <div class="core"> <a href="/la/authors/publish-an-article" class="link" data-track="click" data-track-label="/la/authors/campaigns/in-review" data-track-category="sn:content-page-mainnav" data-track-component="teaser-navigation - Publish an article - /la/authors/publish-an-article">Publish an article</a> </div> </div></div></li><li class="collection-navigation-header--listwrap column" id="publish-a-book"><div id="c25985944" class="collection-navigation-header-level-2--style-default collection collection-navigation-header-level-2 item-3 item-3-4"><div> <div class="core"> <a href="#/la/authors/publish-a-book" class="link flap--mobile " data-section-link="/la/authors/publish-a-book" data-track-category="sn:content-page-mainnav">Publish a book</a> <div> <ul class="row row-block-grid small-up-1 medium-up-2 large-up-2"><li class="collection-navigation-header-level-2--listwrap column" id="" data-mh="25985944"><div id="c25985956" class="collection collection-navigation-header-level-3 item-1 item-1-2"><div> <div class="core"> <ul class=""><li class="collection-navigation-header-level-3--listwrap" id=""><div id="c24626694" class="teaser teaser-navigation-full item-1 item-1-6"><div> <div class="core"> <a href="/la/authors/publish-a-book/roles-and-responsibilities" class="link" data-track="click" data-track-label="/la/authors/campaigns/in-review" data-track-category="sn:content-page-mainnav" data-track-component="teaser-navigation-full - Roles and responsibilities - /la/authors/publish-a-book/roles-and-responsibilities">Roles and responsibilities</a> </div> </div></div></li><li class="collection-navigation-header-level-3--listwrap" id=""><div id="c25345108" class="teaser teaser-navigation-full item-2 item-2-6"><div> <div class="core"> <a href="/la/authors/publish-a-book/signing-your-contract" class="link" data-track="click" data-track-label="/la/authors/campaigns/in-review" data-track-category="sn:content-page-mainnav" data-track-component="teaser-navigation-full - Signing your contract - /la/authors/publish-a-book/signing-your-contract">Signing your contract</a> </div> </div></div></li><li class="collection-navigation-header-level-3--listwrap" id=""><div id="c25345114" class="teaser teaser-navigation-full item-3 item-3-6"><div> <div class="core"> <a href="/la/authors/publish-a-book/writing-your-manuscript" class="link" data-track="click" data-track-label="/la/authors/campaigns/in-review" data-track-category="sn:content-page-mainnav" data-track-component="teaser-navigation-full - Writing your manuscript - /la/authors/publish-a-book/writing-your-manuscript">Writing your manuscript</a> </div> </div></div></li><li class="collection-navigation-header-level-3--listwrap" id=""><div id="c25345620" class="teaser teaser-navigation-full item-4 item-4-6"><div> <div class="core"> <a href="/la/authors/publish-a-book/submitting-your-manuscript" class="link" data-track="click" data-track-label="/la/authors/campaigns/in-review" data-track-category="sn:content-page-mainnav" data-track-component="teaser-navigation-full - Submitting your manuscript - /la/authors/publish-a-book/submitting-your-manuscript">Submitting your manuscript</a> </div> </div></div></li><li class="collection-navigation-header-level-3--listwrap" id=""><div id="c25345622" class="teaser teaser-navigation-full item-5 item-5-6"><div> <div class="core"> <a href="/la/authors/publish-a-book/producing-your-book" class="link" data-track="click" data-track-label="/la/authors/campaigns/in-review" data-track-category="sn:content-page-mainnav" data-track-component="teaser-navigation-full - Producing your book - /la/authors/publish-a-book/producing-your-book">Producing your book</a> </div> </div></div></li><li class="collection-navigation-header-level-3--listwrap" id=""><div id="c25345624" class="teaser teaser-navigation-full item-6 item-6-6 last-item end"><div> <div class="core"> <a href="/la/authors/publish-a-book/promoting-your-book" class="link" data-track="click" data-track-label="/la/authors/campaigns/in-review" data-track-category="sn:content-page-mainnav" data-track-component="teaser-navigation-full - Promoting your book - /la/authors/publish-a-book/promoting-your-book">Promoting your book</a> </div> </div></div></li></ul> </div> </div></div></li><li class="collection-navigation-header-level-2--listwrap column" id="" data-mh="25985944"><div id="c25985958" class="collection collection-navigation-header-level-3 item-2 item-2-2 last-item end"><div> <div class="core"> <ul class=""><li class="collection-navigation-header-level-3--listwrap" id=""><div id="c26015176" class="teaser teaser-navigation-full item-1 item-1-6"><div> <div class="core"> <a href="https://springer.public.springernature.app/link/publish-a-book?utm_source=sn_RM&utm_content=&utm_campaign=CONR_BOOKS_AWA_GL_PBOK_03JC4_SNBPUB24&imprint=SN" class="link" data-track="click" data-track-label="/la/authors/campaigns/in-review" data-track-category="sn:content-page-mainnav" data-track-component="teaser-navigation-full - Submit your book idea - https://springer.public.springernature.app/link/publish-a-book?utm_source=sn_RM&utm_content=&utm_campaign=CONR_BOOKS_AWA_GL_PBOK_03JC4_SNBPUB24&imprint=SN">Submit your book idea</a> </div> </div></div></li><li class="collection-navigation-header-level-3--listwrap" id=""><div id="c25345642" class="teaser teaser-navigation-full item-2 item-2-6"><div> <div class="core"> <a href="/la/authors/publish-a-book/book-types" class="link" data-track="click" data-track-label="/la/authors/campaigns/in-review" data-track-category="sn:content-page-mainnav" data-track-component="teaser-navigation-full - Book types - /la/authors/publish-a-book/book-types">Book types</a> </div> </div></div></li><li class="collection-navigation-header-level-3--listwrap" id=""><div id="c25883332" class="teaser teaser-navigation-full item-3 item-3-6"><div> <div class="core"> <a href="/la/authors/publish-a-book/manuscript-guidelines" class="link" data-track="click" data-track-label="/la/authors/campaigns/in-review" data-track-category="sn:content-page-mainnav" data-track-component="teaser-navigation-full - Manuscript guidelines - /la/authors/publish-a-book/manuscript-guidelines">Manuscript guidelines</a> </div> </div></div></li><li class="collection-navigation-header-level-3--listwrap" id=""><div id="c24621426" class="teaser teaser-navigation-full item-4 item-4-6"><div> <div class="core"> <a href="/la/authors/publish-a-book/book-author-services" class="link" data-track="click" data-track-label="/la/authors/campaigns/in-review" data-track-category="sn:content-page-mainnav" data-track-component="teaser-navigation-full - Book author services - /la/authors/publish-a-book/book-author-services">Book author services</a> </div> </div></div></li><li class="collection-navigation-header-level-3--listwrap" id=""><div id="c27492038" class="teaser teaser-navigation-full item-5 item-5-6"><div> <div class="core"> <a href="/la/authors/publish-a-book/book-author-benefits" class="link" data-track="click" data-track-label="/la/authors/campaigns/in-review" data-track-category="sn:content-page-mainnav" data-track-component="teaser-navigation-full - Book author benefits - /la/authors/publish-a-book/book-author-benefits">Book author benefits</a> </div> </div></div></li><li class="collection-navigation-header-level-3--listwrap" id=""><div id="c25958674" class="teaser teaser-navigation-full item-6 item-6-6 last-item end"><div> <div class="core"> <a href="/la/authors/publish-a-book" class="link" data-track="click" data-track-label="/la/authors/campaigns/in-review" data-track-category="sn:content-page-mainnav" data-track-component="teaser-navigation-full - Publish a book - /la/authors/publish-a-book">Publish a book</a> </div> </div></div></li></ul> </div> </div></div></li></ul> </div> </div> </div></div></li><li class="collection-navigation-header--listwrap column" id=""><div id="c26012208" class="teaser teaser-navigation item-4 item-4-4 last-item end"><div> <div class="core"> <a href="/la/authors/publish-a-book/step-by-step-conference-proceedings" class="link" data-track="click" data-track-label="/la/authors/campaigns/in-review" data-track-category="sn:content-page-mainnav" data-track-component="teaser-navigation - Publish conference proceedings - /la/authors/publish-a-book/step-by-step-conference-proceedings">Publish conference proceedings</a> </div> </div></div></li></ul> </div> </div></div> </div> </div> </div></div></div> </div></div><div id="c-row-2" class="collection collection-page-grid-row item-2 item-2-3"><div> <div class="core"><div id="cmain" class="has-no-image collection collection-page-grid-placement item-1 item-1-1 last-item end"><div> <div class="core"> <div style="data-background-image:url("https://media.springernature.com/full/springer-cms/rest/v1/content/13335174/data/v2");background-color:#0070a8;" id="c16508102" class="has-background-image has-background-color has-no-icon teaser teaser-stage-2 item-1 item-1-7 odd-item section even-item-custom"><div> <div class="row row-block-grid"><div class="column"><div class="core"> <div class="row"> <div class="column small-12 large-8"> <div data-mh="16508102" class="text-group"> <div> <h1 class="headline stage-headline-style-default">In Review</h1> </div> <div class="richtext richtext-default"><p>Journal-integrated preprint sharing from Springer Nature and Research Square</p></div> </div> </div> </div> </div></div></div> </div></div><div id="c16508138" class="has-no-image collection collection-default item-2 item-2-7 even-item section odd-item-custom"><div> <div class="row row-block-grid"><div class="column"><div data-setting-hasHeadline="true" data-setting-grid-columns-small="100" data-setting-grid-columns-medium="auto,33" class="core"> <div class="row row-block-grid"><div class="column medium-8" id="see-your-manuscript-s-review-progress-with-our-first-of-its-kind"><div id="c16505304" class="article article-default item-1 item-1-2"><div> <div class="core"> <div class=""> <div class="richtext richtext-default"><p class="intro--paragraph">Share your preprint and track your manuscript’s review progress with our <em>In Review</em> service</p><p>Our commitment to early sharing and transparency in peer review inspires us to think about how to help our authors in new ways. So, in October 2018, we added a new option for you when you submit to select Springer Nature journals. This first-of-its-kind option, called <em>In Review</em>, brought to you by our partners at Research Square, makes it easy to share a preprint of your manuscript on the Research Square platform and gives you real time updates on your manuscript’s progress through peer review. <em>In Review</em> clearly links your manuscript to the journal reviewing it, while it’s in review. </p><h4>How can you participate?</h4><p>It's simple! Just select the <a href="https://www.researchsquare.com/company/publishers/pre-publication-platform" target="_self" class="is-external" data-track="click" data-track-label="/la/authors/campaigns/in-review" data-track-category="sn:content-page-main-content" data-track-component="richtext-link - In Review - https://www.researchsquare.com/company/publishers/pre-publication-platform"><strong><em>In Review</em></strong></a> option when you submit your next article to one of the participating journals. (<strong>But be sure all your coauthors agree to opt-in</strong>, too.) And here is a <a class="inline-content" data-id="16655860" data-type="CMChannel" href="/la/authors/campaigns/in-review/journals" data-track="click" data-track-label="/la/authors/campaigns/in-review" data-track-category="sn:content-page-main-content" data-track-component="richtext-link - list of journals - /la/authors/campaigns/in-review/journals">list of journals</a> currently on <em>In Review</em>. </p></div> </div> </div> </div></div></div><div class="column medium-4" id="in-review-from-research-square"><div id="c18045094" class="video video-teaser item-2 item-2-2 last-item end"><div> <div class="core"> <div><div id="-N6HrhZ7G7Zpfqc7yPUmjn_-JNN9P8FGp-ZErh3dNx3-g" mi24-video-player="mi24-video-player" video-id="-JNN9P8FGp-ZErh3dNx3-g" player-id="-N6HrhZ7G7Zpfqc7yPUmjn" data-track="click" data-track-component="mi24-video - Learn more about In Review" data-track-label="/springernature-la/la/in-review-from-research-square/18045094" config-type="vmpro" flash-path="//e.video-cdn.net/v2/" api-url="//d.video-cdn.net/play" data-video-mi24-fullscreen="true" class=""> </div><script src="//e.video-cdn.net/v2/embed.js"></script></div> <div class="text-group"> <h3 class="headline headline-h3">Learn more about In Review</h3> <div class="richtext richtext-default"><p>Brought to you by Research Square</p></div> </div> </div> </div></div></div></div> </div></div></div> </div></div><div id="c16508276" class="has-no-image collection collection-general-grid item-3 item-3-7 odd-item section even-item-custom"><div> <div class="row row-block-grid"><div class="column"><div class="core"> <div class="row row-block-grid small-up-1 medium-up-2 large-up-2"><div class="column" id="new-content-item"><div id="c16505960" class="article article-default item-1 item-1-2"><div> <div class="core"> <div class=""> <h2 class="headline headline-h2">With In Review you can:</h2> <div class="richtext richtext-default"><ul><li><strong>Share your work early </strong>with funders and others as a preprint on <a href="https://www.researchsquare.com" target="_self" class="is-external" data-track="click" data-track-label="/la/authors/campaigns/in-review" data-track-category="sn:content-page-main-content" data-track-component="richtext-link - Research Square - https://www.researchsquare.com">Research Square</a> in a citeable way while it is under review, and engage the wider community in discussion to help make your article even better including through the Hypothes.is open annotation tool. And social sharing of your preprint is easy—every article page has social media buttons at the top</li><li><strong>Track the status of your manuscript</strong>, including when reviews have been received (see below for details)</li><li><strong>Benefit from early sharing,</strong> such as more collaboration opportunities and earlier citations</li></ul><h1>Your peers will be able to:</h1><ul><li>Comment on/see emerging science in full HTML—in both phone and desktop-friendly sizes</li><li>Find new discoveries with fully-indexed search</li><li>Gain insight into the peer review pipeline at participating journals</li></ul></div> </div> </div> </div></div></div><div class="column" id="new-content-item"><div id="c16505964" class="article article-default item-2 item-2-2 last-item end"><div> <div class="core"> <div class=""> <h2 class="headline headline-h2">What can you expect if you opt in?</h2> <div class="richtext richtext-default"><p class="intro--paragraph">The editorial and peer review process will continue through the peer review systems as usual. You can use <em>In Review</em> to access up-to-date information on where your article is in the peer review process. </p><p>The system will also immediately post a preprint of your manuscript to the <em>In Review</em> section of Research Square, in easy-to-read HTML, and with a citeable DOI. There, it will become a <strong>permanent part of the scholarly record</strong>—that means that your manuscript will permanently remain publicly available, regardless of whether the journal you submitted it to accepts it or not. (The <strong><a href="/la/authors/campaigns/in-review/faqs" target="_self" data-track="click" data-track-label="/la/authors/campaigns/in-review" data-track-category="sn:content-page-main-content" data-track-component="richtext-link - FAQ - /la/authors/campaigns/in-review/faqs">FAQ</a></strong> has more details about the mechanics of how this works.)</p><p><a href="https://www.researchsquare.com/article/rs-954/v1" target="_self" class="is-external" data-track="click" data-track-label="/la/authors/campaigns/in-review" data-track-category="sn:content-page-main-content" data-track-component="richtext-link - How your article will look on In Review © CC-BY 4.0 - https://www.researchsquare.com/article/rs-954/v1"><img alt="How your article will look on In Review © CC-BY 4.0" class="float--right" title="How your article will look on In Review © CC-BY 4.0" src="//media.springernature.com/full/springer-cms/rest/v1/content/18044284/data/v4" /></a></p><p>You can see an example in the <a href="https://www.researchsquare.com/article/rs-954/v1" target="_self" class="is-external" data-track="click" data-track-label="/la/authors/campaigns/in-review" data-track-category="sn:content-page-main-content" data-track-component="richtext-link - article above - https://www.researchsquare.com/article/rs-954/v1">article above</a>.  </p></div> </div> </div> </div></div></div></div> </div></div></div> </div></div><div id="c16508092" class="has-no-image collection collection-general-grid item-4 item-4-7 even-item section odd-item-custom"><div> <div class="row row-block-grid"><div class="column"><div class="core"> <h2 class="headline headline-h2">What happens when you opt in to In Review? </h2> <div class="row row-block-grid small-up-1 medium-up-2 large-up-4"><div class="column" id=""><div id="c16508072" class="teaser teaser-default item-1 item-1-8" data-mh="16508092"><div> <div class="teaser-default__no-link core"> <div class="image"><span><img src="data:image/svg+xml;utf8,<%3Fxml version='1.0' encoding='UTF-8'%3F><svg width='1024px' height='768px' viewBox='0 0 1024 768' version='1.1' xmlns='http://www.w3.org/2000/svg' xmlns:xlink='http://www.w3.org/1999/xlink'><title>Loading IMG</title><desc>Created with Sketch.</desc><g id='Loading-IMG' stroke='none' stroke-width='1' fill='none' fill-rule='evenodd'><rect fill='%23EBF1F5' x='0' y='0' width='1024' height='768'></rect><rect id='Rectangle' fill='%23DFEDF2' x='0' y='0' width='1024' height='770'></rect><path d='M546.960938,374.039062 C543.510399,374.039062 540.2715,373.388027 537.244141,372.085938 C534.216782,370.783848 531.580089,368.993501 529.333984,366.714844 C527.087879,364.436187 525.297533,361.783218 523.962891,358.755859 C522.628249,355.7285 521.960938,352.489601 521.960938,349.039062 C521.960938,345.588524 522.628249,342.349625 523.962891,339.322266 C525.297533,336.294907 527.087879,333.641938 529.333984,331.363281 C531.580089,329.084624 534.216782,327.294277 537.244141,325.992188 C540.2715,324.690098 543.510399,324.039062 546.960938,324.039062 C550.411476,324.039062 553.666651,324.690098 556.726562,325.992188 C559.786474,327.294277 562.439442,329.084624 564.685547,331.363281 C566.931652,333.641938 568.705723,336.294907 570.007812,339.322266 C571.309902,342.349625 571.960938,345.588524 571.960938,349.039062 C571.960938,352.489601 571.309902,355.7285 570.007812,358.755859 C568.705723,361.783218 566.931652,364.436187 564.685547,366.714844 C562.439442,368.993501 559.786474,370.783848 556.726562,372.085938 C553.666651,373.388027 550.411476,374.039062 546.960938,374.039062 Z M546.960938,334 C542.859354,334 539.343765,335.464829 536.414062,338.394531 C533.48436,341.324233 532.019531,344.872375 532.019531,349.039062 C532.019531,353.20575 533.48436,356.753892 536.414062,359.683594 C539.343765,362.613296 542.859354,364.078125 546.960938,364.078125 C551.127625,364.078125 554.675767,362.613296 557.605469,359.683594 C560.535171,356.753892 562,353.20575 562,349.039062 C562,344.872375 560.535171,341.324233 557.605469,338.394531 C554.675767,335.464829 551.127625,334 546.960938,334 Z M596.960938,284 C601.127625,284 604.675767,285.464829 607.605469,288.394531 C610.535171,291.324233 612,294.872375 612,299.039062 L612,469.058594 C612,473.160177 610.535171,476.675767 607.605469,479.605469 C604.675767,482.535171 601.127625,484 596.960938,484 L427.039062,484 C422.872375,484 419.324233,482.535171 416.394531,479.605469 C413.464829,476.675767 412,473.160177 412,469.058594 L412,299.039062 C412,294.872375 413.464829,291.324233 416.394531,288.394531 C419.324233,285.464829 422.872375,284 427.039062,284 L596.960938,284 Z M421.960938,469.058594 C421.960938,470.425788 422.449214,471.597651 423.425781,472.574219 C424.402349,473.550786 425.606764,474.039062 427.039062,474.039062 L565.320312,474.039062 L470.300781,374.722656 C469.84505,374.266925 469.340498,373.925131 468.787109,373.697266 C468.233721,373.4694 467.664065,373.355469 467.078125,373.355469 C466.492185,373.355469 465.938805,373.485676 465.417969,373.746094 C464.897133,374.006512 464.408856,374.364581 463.953125,374.820312 L421.960938,421.011719 L421.960938,469.058594 Z M602.039062,469.058594 L602.039062,299.039062 C602.039062,297.671868 601.550786,296.500005 600.574219,295.523438 C599.597651,294.54687 598.393236,294.058594 596.960938,294.058594 L427.039062,294.058594 C425.606764,294.058594 424.402349,294.54687 423.425781,295.523438 C422.449214,296.500005 421.960938,297.671868 421.960938,299.039062 L421.960938,406.070312 L456.53125,368.082031 C457.898444,366.584628 459.477205,365.429041 461.267578,364.615234 C463.057952,363.801428 464.962229,363.361979 466.980469,363.296875 C468.998708,363.296875 470.902986,363.687496 472.693359,364.46875 C474.483733,365.250004 476.095045,366.356764 477.527344,367.789062 L579.089844,474.039062 L596.960938,474.039062 C598.393236,474.039062 599.597651,473.550786 600.574219,472.574219 C601.550786,471.597651 602.039062,470.425788 602.039062,469.058594 Z' id='%EE%9C%8E' fill='%238FAEC1' fill-rule='nonzero' opacity='0.5'></path></g></svg>" alt="1. Opt in" data-src="https://media.springernature.com/full/springer-cms/rest/v1/content/18076908/data/v1" style="max-height: 230px" title="1. Opt in | © Springer Nature" /></span></div> <div class="text-group"> <h3 class="headline">1. Opt in</h3> <div class="richtext richtext-default"><p>When you submit your article through the manuscript submission system you will get the chance to opt in to <em>In Review</em>. <strong>All coauthors must agree to post a preprint and participate in <em>In Review</em>. </strong></p></div> </div> </div> </div></div></div><div class="column" id=""><div id="c16508078" class="teaser teaser-default item-2 item-2-8" data-mh="16508092"><div> <div class="teaser-default__no-link core"> <div class="image"><span><img src="data:image/svg+xml;utf8,<%3Fxml version='1.0' encoding='UTF-8'%3F><svg width='1024px' height='768px' viewBox='0 0 1024 768' version='1.1' xmlns='http://www.w3.org/2000/svg' xmlns:xlink='http://www.w3.org/1999/xlink'><title>Loading IMG</title><desc>Created with Sketch.</desc><g id='Loading-IMG' stroke='none' stroke-width='1' fill='none' fill-rule='evenodd'><rect fill='%23EBF1F5' x='0' y='0' width='1024' height='768'></rect><rect id='Rectangle' fill='%23DFEDF2' x='0' y='0' width='1024' height='770'></rect><path d='M546.960938,374.039062 C543.510399,374.039062 540.2715,373.388027 537.244141,372.085938 C534.216782,370.783848 531.580089,368.993501 529.333984,366.714844 C527.087879,364.436187 525.297533,361.783218 523.962891,358.755859 C522.628249,355.7285 521.960938,352.489601 521.960938,349.039062 C521.960938,345.588524 522.628249,342.349625 523.962891,339.322266 C525.297533,336.294907 527.087879,333.641938 529.333984,331.363281 C531.580089,329.084624 534.216782,327.294277 537.244141,325.992188 C540.2715,324.690098 543.510399,324.039062 546.960938,324.039062 C550.411476,324.039062 553.666651,324.690098 556.726562,325.992188 C559.786474,327.294277 562.439442,329.084624 564.685547,331.363281 C566.931652,333.641938 568.705723,336.294907 570.007812,339.322266 C571.309902,342.349625 571.960938,345.588524 571.960938,349.039062 C571.960938,352.489601 571.309902,355.7285 570.007812,358.755859 C568.705723,361.783218 566.931652,364.436187 564.685547,366.714844 C562.439442,368.993501 559.786474,370.783848 556.726562,372.085938 C553.666651,373.388027 550.411476,374.039062 546.960938,374.039062 Z M546.960938,334 C542.859354,334 539.343765,335.464829 536.414062,338.394531 C533.48436,341.324233 532.019531,344.872375 532.019531,349.039062 C532.019531,353.20575 533.48436,356.753892 536.414062,359.683594 C539.343765,362.613296 542.859354,364.078125 546.960938,364.078125 C551.127625,364.078125 554.675767,362.613296 557.605469,359.683594 C560.535171,356.753892 562,353.20575 562,349.039062 C562,344.872375 560.535171,341.324233 557.605469,338.394531 C554.675767,335.464829 551.127625,334 546.960938,334 Z M596.960938,284 C601.127625,284 604.675767,285.464829 607.605469,288.394531 C610.535171,291.324233 612,294.872375 612,299.039062 L612,469.058594 C612,473.160177 610.535171,476.675767 607.605469,479.605469 C604.675767,482.535171 601.127625,484 596.960938,484 L427.039062,484 C422.872375,484 419.324233,482.535171 416.394531,479.605469 C413.464829,476.675767 412,473.160177 412,469.058594 L412,299.039062 C412,294.872375 413.464829,291.324233 416.394531,288.394531 C419.324233,285.464829 422.872375,284 427.039062,284 L596.960938,284 Z M421.960938,469.058594 C421.960938,470.425788 422.449214,471.597651 423.425781,472.574219 C424.402349,473.550786 425.606764,474.039062 427.039062,474.039062 L565.320312,474.039062 L470.300781,374.722656 C469.84505,374.266925 469.340498,373.925131 468.787109,373.697266 C468.233721,373.4694 467.664065,373.355469 467.078125,373.355469 C466.492185,373.355469 465.938805,373.485676 465.417969,373.746094 C464.897133,374.006512 464.408856,374.364581 463.953125,374.820312 L421.960938,421.011719 L421.960938,469.058594 Z M602.039062,469.058594 L602.039062,299.039062 C602.039062,297.671868 601.550786,296.500005 600.574219,295.523438 C599.597651,294.54687 598.393236,294.058594 596.960938,294.058594 L427.039062,294.058594 C425.606764,294.058594 424.402349,294.54687 423.425781,295.523438 C422.449214,296.500005 421.960938,297.671868 421.960938,299.039062 L421.960938,406.070312 L456.53125,368.082031 C457.898444,366.584628 459.477205,365.429041 461.267578,364.615234 C463.057952,363.801428 464.962229,363.361979 466.980469,363.296875 C468.998708,363.296875 470.902986,363.687496 472.693359,364.46875 C474.483733,365.250004 476.095045,366.356764 477.527344,367.789062 L579.089844,474.039062 L596.960938,474.039062 C598.393236,474.039062 599.597651,473.550786 600.574219,472.574219 C601.550786,471.597651 602.039062,470.425788 602.039062,469.058594 Z' id='%EE%9C%8E' fill='%238FAEC1' fill-rule='nonzero' opacity='0.5'></path></g></svg>" alt="2. Quality control checks" data-src="https://media.springernature.com/full/springer-cms/rest/v1/content/18076902/data/v1" style="max-height: 230px" title="2. Quality control checks | © Springer Nature" /></span></div> <div class="text-group"> <h3 class="headline">2. Quality control checks</h3> <div class="richtext richtext-default"><p>If you choose to opt in, your article will undergo some basic quality control checks before being sent to the <em>In Review</em> platform. </p></div> </div> </div> </div></div></div><div class="column" id=""><div id="c16508080" class="teaser teaser-default item-3 item-3-8" data-mh="16508092"><div> <div class="teaser-default__no-link core"> <div class="image"><span><img src="data:image/svg+xml;utf8,<%3Fxml version='1.0' encoding='UTF-8'%3F><svg width='1024px' height='768px' viewBox='0 0 1024 768' version='1.1' xmlns='http://www.w3.org/2000/svg' xmlns:xlink='http://www.w3.org/1999/xlink'><title>Loading IMG</title><desc>Created with Sketch.</desc><g id='Loading-IMG' stroke='none' stroke-width='1' fill='none' fill-rule='evenodd'><rect fill='%23EBF1F5' x='0' y='0' width='1024' height='768'></rect><rect id='Rectangle' fill='%23DFEDF2' x='0' y='0' width='1024' height='770'></rect><path d='M546.960938,374.039062 C543.510399,374.039062 540.2715,373.388027 537.244141,372.085938 C534.216782,370.783848 531.580089,368.993501 529.333984,366.714844 C527.087879,364.436187 525.297533,361.783218 523.962891,358.755859 C522.628249,355.7285 521.960938,352.489601 521.960938,349.039062 C521.960938,345.588524 522.628249,342.349625 523.962891,339.322266 C525.297533,336.294907 527.087879,333.641938 529.333984,331.363281 C531.580089,329.084624 534.216782,327.294277 537.244141,325.992188 C540.2715,324.690098 543.510399,324.039062 546.960938,324.039062 C550.411476,324.039062 553.666651,324.690098 556.726562,325.992188 C559.786474,327.294277 562.439442,329.084624 564.685547,331.363281 C566.931652,333.641938 568.705723,336.294907 570.007812,339.322266 C571.309902,342.349625 571.960938,345.588524 571.960938,349.039062 C571.960938,352.489601 571.309902,355.7285 570.007812,358.755859 C568.705723,361.783218 566.931652,364.436187 564.685547,366.714844 C562.439442,368.993501 559.786474,370.783848 556.726562,372.085938 C553.666651,373.388027 550.411476,374.039062 546.960938,374.039062 Z M546.960938,334 C542.859354,334 539.343765,335.464829 536.414062,338.394531 C533.48436,341.324233 532.019531,344.872375 532.019531,349.039062 C532.019531,353.20575 533.48436,356.753892 536.414062,359.683594 C539.343765,362.613296 542.859354,364.078125 546.960938,364.078125 C551.127625,364.078125 554.675767,362.613296 557.605469,359.683594 C560.535171,356.753892 562,353.20575 562,349.039062 C562,344.872375 560.535171,341.324233 557.605469,338.394531 C554.675767,335.464829 551.127625,334 546.960938,334 Z M596.960938,284 C601.127625,284 604.675767,285.464829 607.605469,288.394531 C610.535171,291.324233 612,294.872375 612,299.039062 L612,469.058594 C612,473.160177 610.535171,476.675767 607.605469,479.605469 C604.675767,482.535171 601.127625,484 596.960938,484 L427.039062,484 C422.872375,484 419.324233,482.535171 416.394531,479.605469 C413.464829,476.675767 412,473.160177 412,469.058594 L412,299.039062 C412,294.872375 413.464829,291.324233 416.394531,288.394531 C419.324233,285.464829 422.872375,284 427.039062,284 L596.960938,284 Z M421.960938,469.058594 C421.960938,470.425788 422.449214,471.597651 423.425781,472.574219 C424.402349,473.550786 425.606764,474.039062 427.039062,474.039062 L565.320312,474.039062 L470.300781,374.722656 C469.84505,374.266925 469.340498,373.925131 468.787109,373.697266 C468.233721,373.4694 467.664065,373.355469 467.078125,373.355469 C466.492185,373.355469 465.938805,373.485676 465.417969,373.746094 C464.897133,374.006512 464.408856,374.364581 463.953125,374.820312 L421.960938,421.011719 L421.960938,469.058594 Z M602.039062,469.058594 L602.039062,299.039062 C602.039062,297.671868 601.550786,296.500005 600.574219,295.523438 C599.597651,294.54687 598.393236,294.058594 596.960938,294.058594 L427.039062,294.058594 C425.606764,294.058594 424.402349,294.54687 423.425781,295.523438 C422.449214,296.500005 421.960938,297.671868 421.960938,299.039062 L421.960938,406.070312 L456.53125,368.082031 C457.898444,366.584628 459.477205,365.429041 461.267578,364.615234 C463.057952,363.801428 464.962229,363.361979 466.980469,363.296875 C468.998708,363.296875 470.902986,363.687496 472.693359,364.46875 C474.483733,365.250004 476.095045,366.356764 477.527344,367.789062 L579.089844,474.039062 L596.960938,474.039062 C598.393236,474.039062 599.597651,473.550786 600.574219,472.574219 C601.550786,471.597651 602.039062,470.425788 602.039062,469.058594 Z' id='%EE%9C%8E' fill='%238FAEC1' fill-rule='nonzero' opacity='0.5'></path></g></svg>" alt="3. Preprint deposition" data-src="https://media.springernature.com/full/springer-cms/rest/v1/content/18076904/data/v1" style="max-height: 230px" title="3. Preprint deposition | © Springer Nature" /></span></div> <div class="text-group"> <h3 class="headline">3. Preprint deposition</h3> <div class="richtext richtext-default"><p>Research Square converts the manuscript to HTML, assigns a DOI, and posts on the platform with a CC-BY license. This is public, and permanent. </p></div> </div> </div> </div></div></div><div class="column" id=""><div id="c16508082" class="teaser teaser-default item-4 item-4-8" data-mh="16508092"><div> <div class="teaser-default__no-link core"> <div class="image"><span><img src="data:image/svg+xml;utf8,<%3Fxml version='1.0' encoding='UTF-8'%3F><svg width='1024px' height='768px' viewBox='0 0 1024 768' version='1.1' xmlns='http://www.w3.org/2000/svg' xmlns:xlink='http://www.w3.org/1999/xlink'><title>Loading IMG</title><desc>Created with Sketch.</desc><g id='Loading-IMG' stroke='none' stroke-width='1' fill='none' fill-rule='evenodd'><rect fill='%23EBF1F5' x='0' y='0' width='1024' height='768'></rect><rect id='Rectangle' fill='%23DFEDF2' x='0' y='0' width='1024' height='770'></rect><path d='M546.960938,374.039062 C543.510399,374.039062 540.2715,373.388027 537.244141,372.085938 C534.216782,370.783848 531.580089,368.993501 529.333984,366.714844 C527.087879,364.436187 525.297533,361.783218 523.962891,358.755859 C522.628249,355.7285 521.960938,352.489601 521.960938,349.039062 C521.960938,345.588524 522.628249,342.349625 523.962891,339.322266 C525.297533,336.294907 527.087879,333.641938 529.333984,331.363281 C531.580089,329.084624 534.216782,327.294277 537.244141,325.992188 C540.2715,324.690098 543.510399,324.039062 546.960938,324.039062 C550.411476,324.039062 553.666651,324.690098 556.726562,325.992188 C559.786474,327.294277 562.439442,329.084624 564.685547,331.363281 C566.931652,333.641938 568.705723,336.294907 570.007812,339.322266 C571.309902,342.349625 571.960938,345.588524 571.960938,349.039062 C571.960938,352.489601 571.309902,355.7285 570.007812,358.755859 C568.705723,361.783218 566.931652,364.436187 564.685547,366.714844 C562.439442,368.993501 559.786474,370.783848 556.726562,372.085938 C553.666651,373.388027 550.411476,374.039062 546.960938,374.039062 Z M546.960938,334 C542.859354,334 539.343765,335.464829 536.414062,338.394531 C533.48436,341.324233 532.019531,344.872375 532.019531,349.039062 C532.019531,353.20575 533.48436,356.753892 536.414062,359.683594 C539.343765,362.613296 542.859354,364.078125 546.960938,364.078125 C551.127625,364.078125 554.675767,362.613296 557.605469,359.683594 C560.535171,356.753892 562,353.20575 562,349.039062 C562,344.872375 560.535171,341.324233 557.605469,338.394531 C554.675767,335.464829 551.127625,334 546.960938,334 Z M596.960938,284 C601.127625,284 604.675767,285.464829 607.605469,288.394531 C610.535171,291.324233 612,294.872375 612,299.039062 L612,469.058594 C612,473.160177 610.535171,476.675767 607.605469,479.605469 C604.675767,482.535171 601.127625,484 596.960938,484 L427.039062,484 C422.872375,484 419.324233,482.535171 416.394531,479.605469 C413.464829,476.675767 412,473.160177 412,469.058594 L412,299.039062 C412,294.872375 413.464829,291.324233 416.394531,288.394531 C419.324233,285.464829 422.872375,284 427.039062,284 L596.960938,284 Z M421.960938,469.058594 C421.960938,470.425788 422.449214,471.597651 423.425781,472.574219 C424.402349,473.550786 425.606764,474.039062 427.039062,474.039062 L565.320312,474.039062 L470.300781,374.722656 C469.84505,374.266925 469.340498,373.925131 468.787109,373.697266 C468.233721,373.4694 467.664065,373.355469 467.078125,373.355469 C466.492185,373.355469 465.938805,373.485676 465.417969,373.746094 C464.897133,374.006512 464.408856,374.364581 463.953125,374.820312 L421.960938,421.011719 L421.960938,469.058594 Z M602.039062,469.058594 L602.039062,299.039062 C602.039062,297.671868 601.550786,296.500005 600.574219,295.523438 C599.597651,294.54687 598.393236,294.058594 596.960938,294.058594 L427.039062,294.058594 C425.606764,294.058594 424.402349,294.54687 423.425781,295.523438 C422.449214,296.500005 421.960938,297.671868 421.960938,299.039062 L421.960938,406.070312 L456.53125,368.082031 C457.898444,366.584628 459.477205,365.429041 461.267578,364.615234 C463.057952,363.801428 464.962229,363.361979 466.980469,363.296875 C468.998708,363.296875 470.902986,363.687496 472.693359,364.46875 C474.483733,365.250004 476.095045,366.356764 477.527344,367.789062 L579.089844,474.039062 L596.960938,474.039062 C598.393236,474.039062 599.597651,473.550786 600.574219,472.574219 C601.550786,471.597651 602.039062,470.425788 602.039062,469.058594 Z' id='%EE%9C%8E' fill='%238FAEC1' fill-rule='nonzero' opacity='0.5'></path></g></svg>" alt="4. Author notification" data-src="https://media.springernature.com/full/springer-cms/rest/v1/content/18076912/data/v1" style="max-height: 230px" title="4. Author notification | © Springer Nature" /></span></div> <div class="text-group"> <h3 class="headline">4. Author notification</h3> <div class="richtext richtext-default"><p>Research Square notifies authors of preprint posting, and sends a link to the author dashboard. Authors will need to create an account (i.e., password) before logging in to see the dashboard.</p></div> </div> </div> </div></div></div><div class="column" id=""><div id="c16508084" class="teaser teaser-default item-5 item-5-8" data-mh="16508092"><div> <div class="teaser-default__no-link core"> <div class="image"><span><img src="data:image/svg+xml;utf8,<%3Fxml version='1.0' encoding='UTF-8'%3F><svg width='1024px' height='768px' viewBox='0 0 1024 768' version='1.1' xmlns='http://www.w3.org/2000/svg' xmlns:xlink='http://www.w3.org/1999/xlink'><title>Loading IMG</title><desc>Created with Sketch.</desc><g id='Loading-IMG' stroke='none' stroke-width='1' fill='none' fill-rule='evenodd'><rect fill='%23EBF1F5' x='0' y='0' width='1024' height='768'></rect><rect id='Rectangle' fill='%23DFEDF2' x='0' y='0' width='1024' height='770'></rect><path d='M546.960938,374.039062 C543.510399,374.039062 540.2715,373.388027 537.244141,372.085938 C534.216782,370.783848 531.580089,368.993501 529.333984,366.714844 C527.087879,364.436187 525.297533,361.783218 523.962891,358.755859 C522.628249,355.7285 521.960938,352.489601 521.960938,349.039062 C521.960938,345.588524 522.628249,342.349625 523.962891,339.322266 C525.297533,336.294907 527.087879,333.641938 529.333984,331.363281 C531.580089,329.084624 534.216782,327.294277 537.244141,325.992188 C540.2715,324.690098 543.510399,324.039062 546.960938,324.039062 C550.411476,324.039062 553.666651,324.690098 556.726562,325.992188 C559.786474,327.294277 562.439442,329.084624 564.685547,331.363281 C566.931652,333.641938 568.705723,336.294907 570.007812,339.322266 C571.309902,342.349625 571.960938,345.588524 571.960938,349.039062 C571.960938,352.489601 571.309902,355.7285 570.007812,358.755859 C568.705723,361.783218 566.931652,364.436187 564.685547,366.714844 C562.439442,368.993501 559.786474,370.783848 556.726562,372.085938 C553.666651,373.388027 550.411476,374.039062 546.960938,374.039062 Z M546.960938,334 C542.859354,334 539.343765,335.464829 536.414062,338.394531 C533.48436,341.324233 532.019531,344.872375 532.019531,349.039062 C532.019531,353.20575 533.48436,356.753892 536.414062,359.683594 C539.343765,362.613296 542.859354,364.078125 546.960938,364.078125 C551.127625,364.078125 554.675767,362.613296 557.605469,359.683594 C560.535171,356.753892 562,353.20575 562,349.039062 C562,344.872375 560.535171,341.324233 557.605469,338.394531 C554.675767,335.464829 551.127625,334 546.960938,334 Z M596.960938,284 C601.127625,284 604.675767,285.464829 607.605469,288.394531 C610.535171,291.324233 612,294.872375 612,299.039062 L612,469.058594 C612,473.160177 610.535171,476.675767 607.605469,479.605469 C604.675767,482.535171 601.127625,484 596.960938,484 L427.039062,484 C422.872375,484 419.324233,482.535171 416.394531,479.605469 C413.464829,476.675767 412,473.160177 412,469.058594 L412,299.039062 C412,294.872375 413.464829,291.324233 416.394531,288.394531 C419.324233,285.464829 422.872375,284 427.039062,284 L596.960938,284 Z M421.960938,469.058594 C421.960938,470.425788 422.449214,471.597651 423.425781,472.574219 C424.402349,473.550786 425.606764,474.039062 427.039062,474.039062 L565.320312,474.039062 L470.300781,374.722656 C469.84505,374.266925 469.340498,373.925131 468.787109,373.697266 C468.233721,373.4694 467.664065,373.355469 467.078125,373.355469 C466.492185,373.355469 465.938805,373.485676 465.417969,373.746094 C464.897133,374.006512 464.408856,374.364581 463.953125,374.820312 L421.960938,421.011719 L421.960938,469.058594 Z M602.039062,469.058594 L602.039062,299.039062 C602.039062,297.671868 601.550786,296.500005 600.574219,295.523438 C599.597651,294.54687 598.393236,294.058594 596.960938,294.058594 L427.039062,294.058594 C425.606764,294.058594 424.402349,294.54687 423.425781,295.523438 C422.449214,296.500005 421.960938,297.671868 421.960938,299.039062 L421.960938,406.070312 L456.53125,368.082031 C457.898444,366.584628 459.477205,365.429041 461.267578,364.615234 C463.057952,363.801428 464.962229,363.361979 466.980469,363.296875 C468.998708,363.296875 470.902986,363.687496 472.693359,364.46875 C474.483733,365.250004 476.095045,366.356764 477.527344,367.789062 L579.089844,474.039062 L596.960938,474.039062 C598.393236,474.039062 599.597651,473.550786 600.574219,472.574219 C601.550786,471.597651 602.039062,470.425788 602.039062,469.058594 Z' id='%EE%9C%8E' fill='%238FAEC1' fill-rule='nonzero' opacity='0.5'></path></g></svg>" alt="5. Author dashboard (private)" data-src="https://media.springernature.com/full/springer-cms/rest/v1/content/18076920/data/v1" style="max-height: 230px" title="5. Author dashboard (private) | © Springer Nature" /></span></div> <div class="text-group"> <h3 class="headline">5. Author dashboard (private)</h3> <div class="richtext richtext-default"><p>Authors will get real time updates on their manuscript’s progress through peer review in the private author dashboard. </p></div> </div> </div> </div></div></div><div class="column" id=""><div id="c16508088" class="teaser teaser-default item-6 item-6-8" data-mh="16508092"><div> <div class="teaser-default__no-link core"> <div class="image"><span><img src="data:image/svg+xml;utf8,<%3Fxml version='1.0' encoding='UTF-8'%3F><svg width='1024px' height='768px' viewBox='0 0 1024 768' version='1.1' xmlns='http://www.w3.org/2000/svg' xmlns:xlink='http://www.w3.org/1999/xlink'><title>Loading IMG</title><desc>Created with Sketch.</desc><g id='Loading-IMG' stroke='none' stroke-width='1' fill='none' fill-rule='evenodd'><rect fill='%23EBF1F5' x='0' y='0' width='1024' height='768'></rect><rect id='Rectangle' fill='%23DFEDF2' x='0' y='0' width='1024' height='770'></rect><path d='M546.960938,374.039062 C543.510399,374.039062 540.2715,373.388027 537.244141,372.085938 C534.216782,370.783848 531.580089,368.993501 529.333984,366.714844 C527.087879,364.436187 525.297533,361.783218 523.962891,358.755859 C522.628249,355.7285 521.960938,352.489601 521.960938,349.039062 C521.960938,345.588524 522.628249,342.349625 523.962891,339.322266 C525.297533,336.294907 527.087879,333.641938 529.333984,331.363281 C531.580089,329.084624 534.216782,327.294277 537.244141,325.992188 C540.2715,324.690098 543.510399,324.039062 546.960938,324.039062 C550.411476,324.039062 553.666651,324.690098 556.726562,325.992188 C559.786474,327.294277 562.439442,329.084624 564.685547,331.363281 C566.931652,333.641938 568.705723,336.294907 570.007812,339.322266 C571.309902,342.349625 571.960938,345.588524 571.960938,349.039062 C571.960938,352.489601 571.309902,355.7285 570.007812,358.755859 C568.705723,361.783218 566.931652,364.436187 564.685547,366.714844 C562.439442,368.993501 559.786474,370.783848 556.726562,372.085938 C553.666651,373.388027 550.411476,374.039062 546.960938,374.039062 Z M546.960938,334 C542.859354,334 539.343765,335.464829 536.414062,338.394531 C533.48436,341.324233 532.019531,344.872375 532.019531,349.039062 C532.019531,353.20575 533.48436,356.753892 536.414062,359.683594 C539.343765,362.613296 542.859354,364.078125 546.960938,364.078125 C551.127625,364.078125 554.675767,362.613296 557.605469,359.683594 C560.535171,356.753892 562,353.20575 562,349.039062 C562,344.872375 560.535171,341.324233 557.605469,338.394531 C554.675767,335.464829 551.127625,334 546.960938,334 Z M596.960938,284 C601.127625,284 604.675767,285.464829 607.605469,288.394531 C610.535171,291.324233 612,294.872375 612,299.039062 L612,469.058594 C612,473.160177 610.535171,476.675767 607.605469,479.605469 C604.675767,482.535171 601.127625,484 596.960938,484 L427.039062,484 C422.872375,484 419.324233,482.535171 416.394531,479.605469 C413.464829,476.675767 412,473.160177 412,469.058594 L412,299.039062 C412,294.872375 413.464829,291.324233 416.394531,288.394531 C419.324233,285.464829 422.872375,284 427.039062,284 L596.960938,284 Z M421.960938,469.058594 C421.960938,470.425788 422.449214,471.597651 423.425781,472.574219 C424.402349,473.550786 425.606764,474.039062 427.039062,474.039062 L565.320312,474.039062 L470.300781,374.722656 C469.84505,374.266925 469.340498,373.925131 468.787109,373.697266 C468.233721,373.4694 467.664065,373.355469 467.078125,373.355469 C466.492185,373.355469 465.938805,373.485676 465.417969,373.746094 C464.897133,374.006512 464.408856,374.364581 463.953125,374.820312 L421.960938,421.011719 L421.960938,469.058594 Z M602.039062,469.058594 L602.039062,299.039062 C602.039062,297.671868 601.550786,296.500005 600.574219,295.523438 C599.597651,294.54687 598.393236,294.058594 596.960938,294.058594 L427.039062,294.058594 C425.606764,294.058594 424.402349,294.54687 423.425781,295.523438 C422.449214,296.500005 421.960938,297.671868 421.960938,299.039062 L421.960938,406.070312 L456.53125,368.082031 C457.898444,366.584628 459.477205,365.429041 461.267578,364.615234 C463.057952,363.801428 464.962229,363.361979 466.980469,363.296875 C468.998708,363.296875 470.902986,363.687496 472.693359,364.46875 C474.483733,365.250004 476.095045,366.356764 477.527344,367.789062 L579.089844,474.039062 L596.960938,474.039062 C598.393236,474.039062 599.597651,473.550786 600.574219,472.574219 C601.550786,471.597651 602.039062,470.425788 602.039062,469.058594 Z' id='%EE%9C%8E' fill='%238FAEC1' fill-rule='nonzero' opacity='0.5'></path></g></svg>" alt="6. Peer review timeline" data-src="https://media.springernature.com/full/springer-cms/rest/v1/content/18076906/data/v1" style="max-height: 231px" title="6. Peer review timeline | © Springer Nature" /></span></div> <div class="text-group"> <h3 class="headline">6. Peer review timeline</h3> <div class="richtext richtext-default"><p>Updates appear on the public peer review timeline as the manuscript progresses through peer review* (*Not available on Nature-branded journals.)</p></div> </div> </div> </div></div></div><div class="column" id=""><div id="c16508090" class="teaser teaser-default item-7 item-7-8" data-mh="16508092"><div> <div class="teaser-default__no-link core"> <div class="image"><span><img src="data:image/svg+xml;utf8,<%3Fxml version='1.0' encoding='UTF-8'%3F><svg width='1024px' height='768px' viewBox='0 0 1024 768' version='1.1' xmlns='http://www.w3.org/2000/svg' xmlns:xlink='http://www.w3.org/1999/xlink'><title>Loading IMG</title><desc>Created with Sketch.</desc><g id='Loading-IMG' stroke='none' stroke-width='1' fill='none' fill-rule='evenodd'><rect fill='%23EBF1F5' x='0' y='0' width='1024' height='768'></rect><rect id='Rectangle' fill='%23DFEDF2' x='0' y='0' width='1024' height='770'></rect><path d='M546.960938,374.039062 C543.510399,374.039062 540.2715,373.388027 537.244141,372.085938 C534.216782,370.783848 531.580089,368.993501 529.333984,366.714844 C527.087879,364.436187 525.297533,361.783218 523.962891,358.755859 C522.628249,355.7285 521.960938,352.489601 521.960938,349.039062 C521.960938,345.588524 522.628249,342.349625 523.962891,339.322266 C525.297533,336.294907 527.087879,333.641938 529.333984,331.363281 C531.580089,329.084624 534.216782,327.294277 537.244141,325.992188 C540.2715,324.690098 543.510399,324.039062 546.960938,324.039062 C550.411476,324.039062 553.666651,324.690098 556.726562,325.992188 C559.786474,327.294277 562.439442,329.084624 564.685547,331.363281 C566.931652,333.641938 568.705723,336.294907 570.007812,339.322266 C571.309902,342.349625 571.960938,345.588524 571.960938,349.039062 C571.960938,352.489601 571.309902,355.7285 570.007812,358.755859 C568.705723,361.783218 566.931652,364.436187 564.685547,366.714844 C562.439442,368.993501 559.786474,370.783848 556.726562,372.085938 C553.666651,373.388027 550.411476,374.039062 546.960938,374.039062 Z M546.960938,334 C542.859354,334 539.343765,335.464829 536.414062,338.394531 C533.48436,341.324233 532.019531,344.872375 532.019531,349.039062 C532.019531,353.20575 533.48436,356.753892 536.414062,359.683594 C539.343765,362.613296 542.859354,364.078125 546.960938,364.078125 C551.127625,364.078125 554.675767,362.613296 557.605469,359.683594 C560.535171,356.753892 562,353.20575 562,349.039062 C562,344.872375 560.535171,341.324233 557.605469,338.394531 C554.675767,335.464829 551.127625,334 546.960938,334 Z M596.960938,284 C601.127625,284 604.675767,285.464829 607.605469,288.394531 C610.535171,291.324233 612,294.872375 612,299.039062 L612,469.058594 C612,473.160177 610.535171,476.675767 607.605469,479.605469 C604.675767,482.535171 601.127625,484 596.960938,484 L427.039062,484 C422.872375,484 419.324233,482.535171 416.394531,479.605469 C413.464829,476.675767 412,473.160177 412,469.058594 L412,299.039062 C412,294.872375 413.464829,291.324233 416.394531,288.394531 C419.324233,285.464829 422.872375,284 427.039062,284 L596.960938,284 Z M421.960938,469.058594 C421.960938,470.425788 422.449214,471.597651 423.425781,472.574219 C424.402349,473.550786 425.606764,474.039062 427.039062,474.039062 L565.320312,474.039062 L470.300781,374.722656 C469.84505,374.266925 469.340498,373.925131 468.787109,373.697266 C468.233721,373.4694 467.664065,373.355469 467.078125,373.355469 C466.492185,373.355469 465.938805,373.485676 465.417969,373.746094 C464.897133,374.006512 464.408856,374.364581 463.953125,374.820312 L421.960938,421.011719 L421.960938,469.058594 Z M602.039062,469.058594 L602.039062,299.039062 C602.039062,297.671868 601.550786,296.500005 600.574219,295.523438 C599.597651,294.54687 598.393236,294.058594 596.960938,294.058594 L427.039062,294.058594 C425.606764,294.058594 424.402349,294.54687 423.425781,295.523438 C422.449214,296.500005 421.960938,297.671868 421.960938,299.039062 L421.960938,406.070312 L456.53125,368.082031 C457.898444,366.584628 459.477205,365.429041 461.267578,364.615234 C463.057952,363.801428 464.962229,363.361979 466.980469,363.296875 C468.998708,363.296875 470.902986,363.687496 472.693359,364.46875 C474.483733,365.250004 476.095045,366.356764 477.527344,367.789062 L579.089844,474.039062 L596.960938,474.039062 C598.393236,474.039062 599.597651,473.550786 600.574219,472.574219 C601.550786,471.597651 602.039062,470.425788 602.039062,469.058594 Z' id='%EE%9C%8E' fill='%238FAEC1' fill-rule='nonzero' opacity='0.5'></path></g></svg>" alt="7. Final Decision" data-src="https://media.springernature.com/full/springer-cms/rest/v1/content/18076914/data/v1" style="max-height: 230px" title="7. Final Decision | © Springer Nature" /></span></div> <div class="text-group"> <h3 class="headline">7. Final Decision</h3> <div class="richtext richtext-default"><p>If the article is published, the preprint is updated with a link to the version of record. If that article is rejected, the journal name and public peer review timeline will be removed but the preprint and any versions of it, if any, will remain public. </p></div> </div> </div> </div></div></div><div class="column" id=""><div id="c16508190" class="teaser teaser-default item-8 item-8-8 last-item end" data-mh="16508092"><div> <div class="core"> <a href="/la/authors/campaigns/in-review/faqs" title="FAQs" data-track="click" data-track-category="sn:content-page-main-content" data-track-component="teaser-default - Still have more questions about In Review? - /la/authors/campaigns/in-review/faqs" data-track-label="/la/authors/campaigns/in-review" class="teaser-default__link"> <div class="text-group"> <h3 class="headline">Still have more questions about In Review?</h3> <div class="richtext richtext-default"><p>If you still have questions about what <em>In Review</em> can do for you or how it works, read our FAQ. </p></div> <span class="teaser-default__arrow-icon"></span> </div> </a> </div> </div></div></div></div> </div></div></div> </div></div><div id="c18035942" class="has-no-image collection collection-general-grid item-5 item-5-7 odd-item section even-item-custom"><div> <div class="row row-block-grid"><div class="column"><div class="core"> <h2 class="headline headline-h2">Find out more about In Review across Springer Nature</h2> <div class="row row-block-grid small-up-1 medium-up-2 large-up-3"><div class="column" id="bmc-and-springeropen"><div id="c18040370" class="article article-default item-1 item-1-3"><div> <div class="core"> <div class=""> <div class="richtext richtext-default"><p><img alt="L_biomedcentral_boxtransparent_600x150" title="L_biomedcentral_boxtransparent_600x150" src="//media.springernature.com/full/springer-cms/rest/v1/content/12250474/data/v2" /></p><p><img alt="Springer Open" title="Springer Open" src="//resource-cms.springernature.com/springer-cms/rest/v1/content/12355788/data/v2" /></p><ul><li>Authors’ original submitted version and all versions are released in real time as peer review progresses</li><li>Public peer review timeline</li><li><p>Authors will be able to track peer review on their private author dashboard</p></li></ul></div> </div> </div> </div></div></div><div class="column" id="nature-research"><div id="c18040358" class="article article-default item-2 item-2-3"><div> <div class="core"> <div class=""> <div class="richtext richtext-default"><p><a href="https://www.nature.com/nature-research/for-authors/in-review" target="_self" class="is-external" data-track="click" data-track-label="/la/authors/campaigns/in-review" data-track-category="sn:content-page-main-content" data-track-component="richtext-link - 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