金属离子在难治性癫痫发病机制中的研究进展

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2.广西脑科学研究重点实验室，南宁  530021; 3.广西职业技术学院，南宁  530226</li> </ol> </address> <ul class="list-unstyled code-style" style="overflow: hidden;"> <li> <span> <code>收稿日期:</code>2024-03-30 </span> <span> <code>修回日期:</code>2024-05-08 </span> <span> </span> <span> <code>出版日期:</code>2024-10-06 </span> <span> <code>发布日期:</code>2024-10-06 </span> </li> <li> <code>通讯作者:</code> 刘媛媛 E-mail:yyliush@163.com </li> <li> </li> <li> </li> </ul> </div>   <h3 class="abs-tit"> Current progress of metal ions in the pathogenesis of refractory epilepsy  </h3> <p data-toggle="collapse" data-target="#divPanelEn"> <span> LI  Hao<sup>1,2</sup>  ZHANG  Ying<sup>3</sup>  LIU  Yuan-yuan<sup>1,2*</sup>    <span data-placement="right" type="button"> <i class="glyphicon glyphicon-menu-down" style="cursor:pointer;"></i> </span> </span> </p> <div id="divPanelEn" class="collapse bs-callout"> <address class="address"> <ol class="list-unstyled"> <li><div style="text-align:justify;"> 1.School of Basic Medical Sciences, Guangxi Medical University, Nanning  530021, China; 2.Guangxi Key Laboratory of Brain Science, Nanning  530021, China; 3.Guangxi Vocational & Technical College, Nanning  530226, China </div></li> </ol> </address> <ul class="list-unstyled code-style" style="overflow: hidden;"> <li> <span> <code>Received:</code>2024-03-30 </span> <span> <code>Revised:</code>2024-05-08 </span> <span> </span> <span> <code>Online:</code>2024-10-06 </span> <span> <code>Published:</code>2024-10-06 </span> </li> <li> <code>Contact:</code> LIU Yuan-yuan E-mail:yyliush@163.com </li> <li> </li> <li> </li> </ul> </div>   <div class="group clearfix"> <div class="row diyihangdg"> <div class="col-xs-6 col-sm-4 col-md-2 col-lg-2 margin-bottom-10"> <span class="change-section"> <a href="#1" onClick="lsdy1('PDF','2863','https://jpxb.bjmu.edu.cn','2024','119');return false;" class="black-bg btn-menu"> <i class="fa fa-file-pdf-o text-danger"></i> <h2>PDF</h2> <span class="badge"> <span id="mag-getXiaZaiShu-2863"></span> <script> $("#mag-getXiaZaiShu-2863").load('/CN/article/getXiaZaiShu.jsp?articleid=2863&ajax=true'); </script> </span> </a> </span> </div>  <div class="col-xs-6 col-sm-4 col-md-2 col-lg-2 margin-bottom-10" id="knowledge_map_div" style="display:none;"> <span class="change-section" onmouseover="changeKnowledgeMapImg(2)" onmouseout="changeKnowledgeMapImg(1)"> <a href="../lexeme/showArticleByLexeme.do?articleID=2863" class="black-bg btn-menu"> <i class="fa text-muted"><img src="../../images/knowledge_map1.png" height="40" style="margin:0px;" width="36" id="knowledge_map_img"></i> <h2>可视化</h2> <span class="badge" id="knowledge_map_count">0</span> </a> </span> </div> </div>  </div>  </div> </div> </div> <div class="row" id="pin"> <div class="col-lg-11 col-md-10 col-sm-12 col-sm-12">  <div class="panel-group" id="accordion" role="tablist" aria-multiselectable="true"> <div class="panel panel-default"> <div class="panel-heading" role="tab" id="zhaiyao" onClick="xianshi(this)" style="cursor: pointer;"> <h4 class="panel-title"> <a id="abstract"> 摘要/Abstract </a> </h4> </div> <div id="collapseOne" class="panel-collapse collapse" role="tabpanel" aria-labelledby="headingOne" name="#abstract" style="display:block;"> <div class="panel-body line-height text-justify"> <p><strong>摘要： </strong><span>癫痫是一种常见的由大脑异常电活动引起的慢性神经系统疾病，其发病机制尚未完全阐明。近年来有越来越多研究证明，大脑中的铁、锌、铜参与癫痫的发生发展过程，可能通过影响相应的离子通道的功能、膜电位的平衡、动作电位的传导、氧化还原等方面，进而影响神经元的兴奋性和信号传导。本文中我们就此进行综述，旨在增进我们对癫痫发病机制的理解，为寻找基于金属离子防治癫痫策略提供新思路。 </span></p> <form name="refForm" action="showCorrelativeArticle.do" method=post target=_blank> <input type="hidden" name="searchSQL" value="" /> <input type=hidden name="keyword" value="" id="keyword"> <input type=hidden name="author" value="" id="author"> <p><strong>关键词: </strong> <a href="#" onClick="searchKeyword('https://jpxb.bjmu.edu.cn','1','癫痫｜金属离子｜神经系统｜离子通道｜螯合治疗&nbsp')">癫痫｜金属离子｜神经系统｜离子通道｜螯合治疗&nbsp</a> </p> <p><strong>Abstract: </strong><div style="text-align:justify;"> Epilepsy is a common chronic neurological disorder caused by abnormal electrical activity in the brain, and its pathogenesis has not been fully clarified. In recent years, more and more studies have shown that iron, zinc and copper in the brain are involved in the occurrence and development of epilepsy. These metal ions possibly play a role in epileptogenesis by affecting neuronal excitability and signal transduction through alterating ion channel function, potential balance, action potential propagation, redox and so on. In this review, we mainly analyse the effects of these metal ions on epilepsy, in order to explore the underlying mechanisms of epilepsy and provide promising therapeutic strategies for epilepsy based on metal ions.  </div></p> </form>  <form name="subjectSchemeForm" action="" method=post target=_blank> <input type="hidden" name="searchSQL" /> <input type="hidden" name="language" /> </form>  <p> <strong> 中图分类号:  </strong> </p> <ul class="list-unstyled pacs"> <li> <p> <a href="#" onclick="subjectScheme('https://jpxb.bjmu.edu.cn','R741','1');return false;" target="_blank"> R741 </a> </p> </li> </ul>  <div class="row hidden-xs hidden-sm"> <div class="col-xs-12 col-sm-2 col-md-2 col-lg-2 margin-bottom-10 text-center"> <div class="text-primary btn-menu"> <h4>引用本文</h4> </div> </div> <div class="col-xs-12 col-sm-10 col-md-10 col-lg-10 margin-bottom-10"> <div class="primary-border"> <p>李昊张莹刘媛媛. 金属离子在难治性癫痫发病机制中的研究进展[J]. 解剖学报, 2024, 55(5): 641-646. </p> <p>LI Hao ZHANG Ying LIU Yuan-yuan. Current progress of metal ions in the pathogenesis of refractory epilepsy [J]. Acta Anatomica Sinica, 2024, 55(5): 641-646.</p> </div> </div> </div> <div class="row hidden-xs hidden-sm"> <div class="col-xs-12 col-sm-2 col-md-2 col-lg-2 margin-bottom-10 text-center"> <div class="btn-menu bs-callout-warning"> <h4>使用本文</h4> </div> </div> <div class="col-xs-12 col-sm-10 col-md-10 col-lg-10 margin-bottom-10"> <div class="primary-border"> <p> <b> <form name=mail action="https://jpxb.bjmu.edu.cn/CN/article/sendMail.jsp" method=post target=_blank> <div class="bshare-custom pull-left"><div class="bsPromo bsPromo2"></div><a title="分享到微信" class="bshare-weixin" href="javascript:void(0);"></a><a title="分享到新浪微博" class="bshare-sinaminiblog" href="javascript:void(0);"></a><a title="分享到QQ空间" class="bshare-qzone"></a><a title="分享到腾讯微博" class="bshare-qqmb"></a><a title="更多平台" class="bshare-more bshare-more-icon more-style-addthis"></a><span class="BSHARE_COUNT bshare-share-count" style="float: none;">0</span></div><script type="text/javascript" charset="utf-8" src="https://static.bshare.cn/b/buttonLite.js#style=-1&uuid=&pophcol=2&lang=zh"></script><script type="text/javascript" charset="utf-8" src="https://static.bshare.cn/b/bshareC0.js"></script>     /   <a href="#" id="collectArticle" class="shouc"></a> <span id="collectCount"></span> /   <a onclick="mail.submit()" href="javascript:void(null)" class="tuij">推荐</a> <input type="hidden" value='我在《解剖学报》上发现了关于“金属离子在难治性癫痫发病机制中的研究进展”的文章，特向您推荐。请打开下面的网址：https://jpxb.bjmu.edu.cn/CN/abstract/abstract2863.shtml' name="neirong"> <input type="hidden" name="thishref" value="https://jpxb.bjmu.edu.cn/CN/abstract/abstract2863.shtml"> <input type="hidden" name="jname" value="解剖学报"> <input type="hidden" name="title" value='金属离子在难治性癫痫发病机制中的研究进展'> <form> </b> </p> <p><b>导出引用管理器</b> <span class="daochu"><a href="https://jpxb.bjmu.edu.cn/CN/article/getTxtFile.do?fileType=EndNote&id=2863" id="ris_export">EndNote</a>|<a href="https://jpxb.bjmu.edu.cn/CN/article/getTxtFile.do?fileType=Ris&id=2863">Reference Manager</a>|<a href="https://jpxb.bjmu.edu.cn/CN/article/getTxtFile.do?fileType=ProCite&id=2863">ProCite</a>|<a id="bibtex_export" href="https://jpxb.bjmu.edu.cn/CN/article/getTxtFile.do?fileType=BibTeX&id=2863">BibTeX</a>|<a href="https://jpxb.bjmu.edu.cn/CN/article/getTxtFile.do?fileType=RefWorks&id=2863">RefWorks</a></span> </p> <p><strong>链接本文:</strong> <a href="https://jpxb.bjmu.edu.cn/CN/10.16098/j.issn.0529-1356.2024.05.017" class="txt_zhaiyao1">https://jpxb.bjmu.edu.cn/CN/10.16098/j.issn.0529-1356.2024.05.017</a> </p> <p> <strong> </strong>              <a href="https://jpxb.bjmu.edu.cn/CN/Y2024/V55/I5/641" class="txt_zhaiyao1"> https://jpxb.bjmu.edu.cn/CN/Y2024/V55/I5/641</a> </p> </div> </div> </div> </div> </div> </div> <div class="panel panel-default" > <div class="panel-heading" role="tab" id="cankaowenxian" onClick="xianshi(this)"> <a name="reference"></a> <h4 class="panel-title"> <a id="reference" class="collapsed" href="javascript:;"> 参考文献 </a> </h4> </div> <div id="collapseThree" class="panel-collapse collapse" role="tabpanel" aria-labelledby="headingThree" style="display: none;"> <div class="panel-body">  <table width="98%" border="0" align="center" cellpadding="0" cellspacing="8"> <tr> <td class="J_author"> <div style="text-align:justify;">    [1］  Tan GH, Liu YY, Hu XL, et al. Neuregulin 1 represses limbic epileptogenesis through ErbB4 in parvalbumin-expressing interneurons ［J］. Nat Neurosci, 2011, 15(2):258-266. </div> <div style="text-align:justify;">   ［2］  Thijs RD, Surges R, O’Brien TJ, et al. Epilepsy in adults ［J］. Lancet, 2019, 393(10172):689-701. </div> <div style="text-align:justify;">   ［3］  Miziak B, Konarzewska A, U?amek-Kozio? M, et al. Anti-epileptogenic effects of antiepileptic drugs ［J］. Int J Mol Sci, 2020, 21(7):2340. </div> <div style="text-align:justify;">   ［4］  Mathie A, Sutton GL, Clarke CE, et al. Zinc and copper: pharmacological probes and endogenous modulators of neuronal excitability ［J］. Pharmacol Ther, 2006, 111(3):567-583. </div> <div style="text-align:justify;">   ［5］  Li L, Guo L, Gao R, et al. Ferroptosis: a new regulatory mechanism in neuropathic pain ［J］. Front Aging Neurosci, 2023, 15:1206851. </div> <div style="text-align:justify;">   ［6］  Luo D, Liu Y, Li J, et al. Systematic Analysis of the Relationship Between Elevated Zinc and Epilepsy ［J］. J Mol Neurosci, 2024, 74(2):39. </div> <div style="text-align:justify;">   ［7］  Ozturk-Sonmez L, Tutkun E, Agar E, et al. The effect of vitamin E supplementation on brain tissue element levels in epileptic rats ［J］. Arch Ital Biol, 2022, 160(1-2):42-53. </div> <div style="text-align:justify;">   ［8］  Zimmer TS, David B, Broekaart DWM, et al. Seizure-mediated iron accumulation and dysregulated iron metabolism after status epilepticus and in temporal lobe epilepsy ［J］. Acta Neuropathol, 2021, 142(4):729-759. </div> <div style="text-align:justify;">   ［9］  Sande R, Doshi G, Godad A. Deciphering the role of metal and non-metals in the treatment of epilepsy ［J］. Neurochem Int, 2023, 167:105536. </div> <div style="text-align:justify;">   ［10］  Chen S, Chen Y, Zhang Y, et al. Iron Metabolism and Ferroptosis in Epilepsy ［J］. Front Neurosci, 2020, 14:601193. </div> <div style="text-align:justify;">   ［11］  Cheah JH, Kim SF, Hester LD, et al. NMDA receptor-nitric oxide transmission mediates neuronal iron homeostasis via the GTPase Dexras1 ［J］. Neuron, 2006, 51(4):431-440. </div> <div style="text-align:justify;">   ［12］  Guan P, Wang N, Duan XL, et al. Effects of intranigeral injection of glutamate and gaba on the expression of divalent metal transporter 1 and hephaestin in the caudate putamen nucleus of rats ［J］. Acta Anatomica Sinica, 2008, 39(6):795-799. （in Chinese）  </div> <div style="text-align:justify;"> 关鹏, 王娜, 段相林, 等. 谷氨酸钠、γ-氨基丁酸注入黑质对大鼠尾壳核二价金属离子转运体1和膜铁转运辅助蛋白表达的影响［J］. 解剖学报, 2008, 39(6):795-799. </div> <div style="text-align:justify;">   ［13］  Su Y, Cao N, Zhang D, et al. The effect of ferroptosis-related mitochondrial dysfunction in the development of temporal lobe epilepsy ［J］. Ageing Res Rev, 2024, 96:102248. </div> <div style="text-align:justify;">   ［14］  Chen J, Li M, Liu Z, et al. Molecular mechanisms of neuronal death in brain injury after subarachnoid hemorrhage ［J］. Front Cell Neurosci, 2022, 16:1025708. </div> <div style="text-align:justify;">   ［15］  Ye L, Zeng Q, Ling M, et al. Inhibition of IP3R/Ca2+ dysregulation protects mice from ventilator-induced lung injury via endoplasmic reticulum and mitochondrial pathways ［J］. Front Immunol, 2021, 12:729094. </div> <div style="text-align:justify;">   ［16］  Lü Z, Han J, Li J, et al. Single cell RNA-seq analysis identifies ferroptotic chondrocyte cluster and reveals TRPV1 as an anti-ferroptotic target in osteoarthritis ［J］. EBioMedicine, 2022, 84:104258. </div> <div style="text-align:justify;">   ［17］  Yang N, Zhang K, Guan QW, et al. D-Penicillamine reveals the amelioration of seizure-induced neuronal injury via inhibiting aqp11-dependent ferroptosis ［J］. Antioxidants (Basel), 2022, 11(8):1602. </div> <div style="text-align:justify;">   ［18］  Jia JN, Yin XX, Li Q, et al. Neuroprotective effects of the anti-cancer drug lapatinib against epileptic seizures via suppressing glutathione peroxidase 4-dependent ferroptosis ［J］. Front Pharmacol, 2020, 11:601572. </div> <div style="text-align:justify;">   ［19］  Li Y, Liu P, Lin Q, et al. Postoperative seizure and memory outcome of temporal lobe epilepsy with hippocampal sclerosis: A systematic review ［J］. Epilepsia, 2023, 64(11):2845-2860. </div> <div style="text-align:justify;">   ［20］  Frederickson CJ, Bush AI. Synaptically released zinc: physiological functions and pathological effects ［J］. Biometals, 2001, 14(3-4):353-366. </div> <div style="text-align:justify;">   ［21］  Crichton RR, Dexter DT, Ward RJ. Metal based neurodegenerative diseases—From molecular mechanisms to therapeutic strategies ［J］. Coord Chem Rev, 2008,252(10/11):1189-1199. </div> <div style="text-align:justify;">   ［22］  Saghazadeh A, Mahmoudi M, Meysamie A, et al. Possible role of trace elements in epilepsy and febrile seizures: a meta-analysis ［J］. Nutr Rev, 2015, 73(11):760-779. </div> <div style="text-align:justify;">   ［23］  Choi S, Hong DK, Choi BY, et al. Zinc in the brain: friend or foe ［J］? Int J Mol Sci, 2020, 21(23):8941. </div> <div style="text-align:justify;">   ［24］  Imbrici P, D’Adamo MC, Cusimano A, et al. Episodic ataxia type 1 mutation F184C alters Zn2+ -induced modulation of the human K+ channel Kv1.4-Kv1.1/Kvbeta1.1 ［J］. Am J Physiol Cell Physiol, 2007, 292(2):C77-C787. </div> <div style="text-align:justify;">   ［25］  van Loo KMJ, Schaub C, Pitsch J, et al. Zinc regulates a key transcriptional pathway for epileptogenesis via metal-regulatory transcription factor 1 ［J］. Nat Commun, 2015, 6:8688. </div> <div style="text-align:justify;">   ［26］  Khalil A, Kovac S, Morris G, et al. Carvacrol after status epilepticus (SE) prevents recurrent SE, early seizures, cell death, and cognitive decline ［J］. Epilepsia, 2017, 58(2):263-273. </div> <div style="text-align:justify;">   ［27］  Khalil A, Shekh-Ahmad T, Kovac S, et al. Drugs acting at TRPM7 channels inhibit seizure-like activity ［J］. Epilepsia Open, 2023, 8(3):1169-1174. </div> <div style="text-align:justify;">   ［28］  Hong DK, Kho AR, Lee SH, et al. Pathophysiological roles of transient receptor potential (Trp) channels and zinc toxicity in brain disease ［J］. Int J Mol Sci, 2023, 24(7):6665. </div> <div style="text-align:justify;">   ［29］  Kim YJ, Kang TC. The role of TRPC6 in seizure susceptibility and seizure-related neuronal damage in the rat dentate gyrus ［J］. Neuroscience, 2015, 307:215-230. </div> <div style="text-align:justify;">   ［30］  Lee CJ, Lee SH, Kang BS, et al. Effects of L-type voltage-gated calcium channel (LTCC) inhibition on hippocampal neuronal death after pilocarpine-induced seizure ［J］. Antioxidants (Basel), 2024, 13(4)：389. </div> <div style="text-align:justify;">   ［31］  Choi BY, Jang BG, Kim JH, et al. Copper/zinc chelation by clioquinol reduces spinal cord white matter damage and behavioral deficits in a murine MOG-induced multiple sclerosis model ［J］. Neurobiol Dis, 2013, 54:382-391. </div> <div style="text-align:justify;">   ［32］  Kho AR, Choi BY, Kim JH, et al. Prevention of hypoglycemia-induced hippocampal neuronal death by N-acetyl-L-cysteine (NAC) ［J］. Amino Acids, 2017, 49(2):367-378. </div> <div style="text-align:justify;">   ［33］  Zhu S, Wu H, Cui H, et al. Induction of mitophagy via ROS-dependent pathway protects copper-induced hypothalamic nerve cell injury ［J］. Food Chem Toxicol, 2023, 181:114097. </div> <div style="text-align:justify;">   ［34］  Gündo?du A, Bolattürk ?F, Aygül R, et al. The relationship of fatigue and depression with trace element levels in epileptic patients ［J］. Biol Trace Elem Res, 2023, 201(3):1135-1142. </div> <div style="text-align:justify;">   ［35］  Talat MA, Ahmed A, Mohammed L. Serum levels of zinc and copper in epileptic children during long-term therapy with anticonvulsants ［J］. Neurosciences (Riyadh), 2015, 20(4):341-345. </div> <div style="text-align:justify;">   ［36］  Liao W, Zhu Z, Feng C, et al. Toxicity mechanisms and bioavailability of copper to fish based on an adverse outcome pathway analysis ［J］. J Environ Sci (China), 2023, 127:495-507. </div> <div style="text-align:justify;">   ［37］  Morera FJ, Wolff D, Vergara C. External copper inhibits the activity of the large-conductance calcium- and voltage-sensitive potassium channel from skeletal muscle ［J］. J Membr Biol, 2003, 192(1):65-72. </div> <div style="text-align:justify;">   ［38］  Peters C, Mu?oz B, Sepúlveda FJ, et al. Biphasic effects of copper on neurotransmission in rat hippocampal neurons ［J］. J Neurochem, 2011, 119(1):78-88. </div> <div style="text-align:justify;">   ［39］  Wen F, Tan Z-G, Xiang J. Cu-Zn SOD suppresses epilepsy in pilocarpine-treated rats and alters SCN2A/Nrf2/HO-1 expression ［J］. Epileptic Disord, 2022, 24(4):647-656. </div> <div style="text-align:justify;">   ［40］  Susankova K, Tousova K, Vyklicky L, et al. Reducing and oxidizing agents sensitize heat-activated vanilloid receptor (TRPV1) current ［J］. Mol Pharmacol, 2006, 70(1):383-394. </div> <div style="text-align:justify;">   ［41］  White AR, Du T, Laughton KM, et al. Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity ［J］. J Biol Chem, 2006, 281(26):17670-17680. </div> <div style="text-align:justify;">   ［42］  Huang Z, Luo Y, Zhang T, et al. A Stimuli-Responsive Small-Molecule Metal-Carrying Prochelator: A Novel Prodrug Design Strategy for Metal Complexes ［J］. Angew Chem Int Ed Engl, 2022, 61(28):e202203500. </div> <div style="text-align:justify;">   ［43］  Palm R, Hallmans G. Zinc and copper metabolism in phenytoin therapy ［J］. Epilepsia, 1982, 23(5):453-461. </div> <div style="text-align:justify;">   ［44］  Verrotti A, Basciani F, Trotta D, et al. Serum copper, zinc, selenium, glutathione peroxidase and superoxide dismutase levels in epileptic children before and after 1 year of sodium valproate and carbamazepine therapy ［J］. Epilepsy Res, 2002, 48(1-2):71-75. </div> <div style="text-align:justify;">   ［45］  Ahn JE, Bathena SPR, Brundage RC, et al. Iron supplements in nursing home patients associated with reduced carbamazepine absorption ［J］. Epilepsy Res, 2018, 147:115-118. </div> <div style="text-align:justify;">   ［46］  Kürek?i AE, Alpay F, Tanindi S, et al. Plasma trace element, plasma glutathione peroxidase, and superoxide dismutase levels in epileptic children receiving antiepileptic drug therapy ［J］. Epilepsia, 1995, 36(6):600-604. </div> <div style="text-align:justify;">   ［47］  Grünspan LD, Mussulini BHM, Baggio S, et al. Teratogenic and anticonvulsant effects of zinc and copper valproate complexes in zebrafish ［J］. 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