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class="vector-toc-list"> </ul> </li> <li id="toc-Further_reading" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Further_reading"> <div class="vector-toc-text"> <span class="vector-toc-numb">9</span> <span>Further reading</span> </div> </a> <ul id="toc-Further_reading-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-External_links" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#External_links"> <div class="vector-toc-text"> <span class="vector-toc-numb">10</span> <span>External links</span> </div> </a> <ul id="toc-External_links-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Contents" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Toggle the table of contents" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Toggle the table of contents</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Fibroblast growth factor receptor 2</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Go to an article in another language. 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data-language-local-name="Arabic" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-bs mw-list-item"><a href="https://bs.wikipedia.org/wiki/FGFR2" title="FGFR2 – Bosnian" lang="bs" hreflang="bs" data-title="FGFR2" data-language-autonym="Bosanski" data-language-local-name="Bosnian" class="interlanguage-link-target"><span>Bosanski</span></a></li><li class="interlanguage-link interwiki-cy mw-list-item"><a href="https://cy.wikipedia.org/wiki/FGFR2" title="FGFR2 – Welsh" lang="cy" hreflang="cy" data-title="FGFR2" data-language-autonym="Cymraeg" data-language-local-name="Welsh" class="interlanguage-link-target"><span>Cymraeg</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%DA%AF%DB%8C%D8%B1%D9%86%D8%AF%D9%87_%DB%B2_%D9%81%D8%A7%DA%A9%D8%AA%D9%88%D8%B1_%D8%B1%D8%B4%D8%AF_%D9%81%DB%8C%D8%A8%D8%B1%D9%88%D8%A8%D9%84%D8%A7%D8%B3%D8%AA" title="گیرنده ۲ فاکتور رشد فیبروبلاست – Persian" lang="fa" hreflang="fa" data-title="گیرنده ۲ فاکتور رشد فیبروبلاست" data-language-autonym="فارسی" data-language-local-name="Persian" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-arz mw-list-item"><a href="https://arz.wikipedia.org/wiki/%D9%85%D8%B3%D8%AA%D9%82%D8%A8%D9%84_%D8%B9%D8%A7%D9%85%D9%84_%D9%86%D9%85%D9%88_%D8%A7%D9%84%D8%AE%D9%84%D9%8A%D9%87_%D8%A7%D9%84%D9%84%D9%8A%D9%81%D9%8A%D9%87_2" title="مستقبل عامل نمو الخليه الليفيه 2 – Egyptian Arabic" lang="arz" hreflang="arz" data-title="مستقبل عامل نمو الخليه الليفيه 2" data-language-autonym="مصرى" data-language-local-name="Egyptian Arabic" class="interlanguage-link-target"><span>مصرى</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%A0%D0%B5%D1%86%D0%B5%D0%BF%D1%82%D0%BE%D1%80_%D1%84%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D0%B0_%D1%80%D0%BE%D1%81%D1%82%D0%B0_%D1%84%D0%B8%D0%B1%D1%80%D0%BE%D0%B1%D0%BB%D0%B0%D1%81%D1%82%D0%BE%D0%B2_2" title="Рецептор фактора роста фибробластов 2 – Russian" lang="ru" hreflang="ru" data-title="Рецептор фактора роста фибробластов 2" data-language-autonym="Русский" data-language-local-name="Russian" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Receptor_2_fibroblastnog_faktora_rasta" title="Receptor 2 fibroblastnog faktora rasta – Serbo-Croatian" lang="sh" hreflang="sh" data-title="Receptor 2 fibroblastnog faktora rasta" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="Serbo-Croatian" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-tt mw-list-item"><a href="https://tt.wikipedia.org/wiki/FGFR2" title="FGFR2 – Tatar" lang="tt" hreflang="tt" data-title="FGFR2" data-language-autonym="Татарча / tatarça" data-language-local-name="Tatar" class="interlanguage-link-target"><span>Татарча / tatarça</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/FGFR2" title="FGFR2 – Ukrainian" lang="uk" hreflang="uk" data-title="FGFR2" data-language-autonym="Українська" data-language-local-name="Ukrainian" class="interlanguage-link-target"><span>Українська</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q14911644#sitelinks-wikipedia" title="Edit interlanguage links" class="wbc-editpage">Edit links</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav 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id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Protein-coding gene in the species Homo sapiens</div> <table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">FGFR2</th></tr><tr><td colspan="4" style="text-align:center"><span typeof="mw:File"><a href="/wiki/File:Protein_FGFR2_PDB_1djs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/9/92/Protein_FGFR2_PDB_1djs.png/250px-Protein_FGFR2_PDB_1djs.png" decoding="async" width="250" height="131" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/92/Protein_FGFR2_PDB_1djs.png/375px-Protein_FGFR2_PDB_1djs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/92/Protein_FGFR2_PDB_1djs.png/500px-Protein_FGFR2_PDB_1djs.png 2x" data-file-width="1018" data-file-height="534" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Available structures</th></tr><tr><th rowspan="2" style="background-color:#c3fdb8;width:43px"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td colspan="2" style="background-color:#eee">Ortholog search: <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/searchResults.html?display=both&term=P21803%20or%20P21802">PDBe</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_name:UniProt%20AND%20rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_accession:P21803,P21802">RCSB</a> </span></td></tr><tr><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr style="background-color:#ddd;text-align:center"><th colspan="2">List of PDB id codes</th></tr><tr><td colspan="2" style="background-color:#eee"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1DJS">1DJS</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1E0O">1E0O</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1EV2">1EV2</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1GJO">1GJO</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1II4">1II4</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1IIL">1IIL</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1NUN">1NUN</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1OEC">1OEC</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1WVZ">1WVZ</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2FDB">2FDB</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2PSQ">2PSQ</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2PVF">2PVF</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2PVY">2PVY</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2PWL">2PWL</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2PY3">2PY3</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2PZ5">2PZ5</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2PZP">2PZP</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2PZR">2PZR</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2Q0B">2Q0B</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3B2T">3B2T</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3CAF">3CAF</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3CLY">3CLY</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3CU1">3CU1</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3DAR">3DAR</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3EUU">3EUU</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3OJ2">3OJ2</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3OJM">3OJM</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3RI1">3RI1</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4J95">4J95</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4J96">4J96</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4J97">4J97</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4J98">4J98</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4J99">4J99</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4J23">4J23</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4WV1">4WV1</a></span></p></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><th colspan="4" style="text-align:center;background-color:#ddd">Identifiers</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><span class="plainlinks"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/3689">FGFR2</a></span>, BBDS, BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25, fibroblast growth factor receptor 2</td></tr><tr><th scope="row" style="background-color:#c3fdb8">External IDs</th><td colspan="3" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/176943">176943</a>; <a href="/wiki/Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:95523">95523</a>; <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=22566">22566</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=FGFR2">FGFR2</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000066468">FGFR2 - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_human_chromosome_10.svg" class="mw-file-description" title="Chromosome 10 (human)"><img alt="Chromosome 10 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/2/2f/Ideogram_human_chromosome_10.svg/300px-Ideogram_human_chromosome_10.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/2f/Ideogram_human_chromosome_10.svg/450px-Ideogram_human_chromosome_10.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/2f/Ideogram_human_chromosome_10.svg/600px-Ideogram_human_chromosome_10.svg.png 2x" data-file-width="474" data-file-height="189" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Chromosome_10_(human)" class="mw-redirect" title="Chromosome 10 (human)">Chromosome 10 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Human_chromosome_10_ideogram.svg" class="mw-file-description" title="Chromosome 10 (human)"><img alt="Chromosome 10 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/e/e0/Human_chromosome_10_ideogram.svg/300px-Human_chromosome_10_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/e/e0/Human_chromosome_10_ideogram.svg/450px-Human_chromosome_10_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/e/e0/Human_chromosome_10_ideogram.svg/600px-Human_chromosome_10_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 261.78360122226px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for FGFR2"><img alt="Genomic location for FGFR2" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 267.8px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for FGFR2"><img alt="Genomic location for FGFR2" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">10q26.13</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">121,478,332 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">121,598,458 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_house_mouse_chromosome_7.svg" class="mw-file-description" title="Chromosome 7 (mouse)"><img alt="Chromosome 7 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/e/e4/Ideogram_house_mouse_chromosome_7.svg/260px-Ideogram_house_mouse_chromosome_7.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/e/e4/Ideogram_house_mouse_chromosome_7.svg/390px-Ideogram_house_mouse_chromosome_7.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/e/e4/Ideogram_house_mouse_chromosome_7.svg/520px-Ideogram_house_mouse_chromosome_7.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks">Chromosome 7 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Ideogram_of_house_mouse_chromosome_7.svg" class="mw-file-description" title="Chromosome 7 (mouse)"><img alt="Chromosome 7 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/2/2c/Ideogram_of_house_mouse_chromosome_7.svg/300px-Ideogram_of_house_mouse_chromosome_7.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/2c/Ideogram_of_house_mouse_chromosome_7.svg/450px-Ideogram_of_house_mouse_chromosome_7.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/2c/Ideogram_of_house_mouse_chromosome_7.svg/600px-Ideogram_of_house_mouse_chromosome_7.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 260.02227553366px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for FGFR2"><img alt="Genomic location for FGFR2" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 264px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_6x18.png" class="mw-file-description" title="Genomic location for FGFR2"><img alt="Genomic location for FGFR2" src="//upload.wikimedia.org/wikipedia/commons/5/5a/Red_rectangle_6x18.png" decoding="async" width="6" height="18" class="mw-file-element" data-file-width="6" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">7|7 F3</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">129,764,181 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">132,725,079 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Human_genome" title="Human genome">Human</a></b></th><th><b><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000066468">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">C1 segment</li><br /><li style="line-height: 137%;">corpus callosum</li><br /><li style="line-height: 137%;">inferior olivary nucleus</li><br /><li style="line-height: 137%;">ventricular zone</li><br /><li style="line-height: 137%;">parotid gland</li><br /><li style="line-height: 137%;">inferior ganglion of vagus nerve</li><br /><li style="line-height: 137%;">external globus pallidus</li><br /><li style="line-height: 137%;">subthalamic nucleus</li><br /><li style="line-height: 137%;">substantia nigra</li><br /><li style="line-height: 137%;">skin of thigh</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000030849">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">calvaria</li><br /><li style="line-height: 137%;">genital tubercle</li><br /><li style="line-height: 137%;">adrenal gland</li><br /><li style="line-height: 137%;">ventricular zone</li><br /><li style="line-height: 137%;">left lung lobe</li><br /><li style="line-height: 137%;">choroid plexus of fourth ventricle</li><br /><li style="line-height: 137%;">epithelium of trachea</li><br /><li style="line-height: 137%;">retinal pigment epithelium</li><br /><li style="line-height: 137%;">medullary collecting duct</li><br /><li style="line-height: 137%;">wall of esophagus</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000066468">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:PBB_GE_FGFR2_208228_s_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/1/1f/PBB_GE_FGFR2_208228_s_at_fs.png/250px-PBB_GE_FGFR2_208228_s_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/1f/PBB_GE_FGFR2_208228_s_at_fs.png/375px-PBB_GE_FGFR2_208228_s_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/1f/PBB_GE_FGFR2_208228_s_at_fs.png/500px-PBB_GE_FGFR2_208228_s_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span><br /><br /><span typeof="mw:File"><a href="/wiki/File:PBB_GE_FGFR2_203638_s_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/7/7a/PBB_GE_FGFR2_203638_s_at_fs.png/250px-PBB_GE_FGFR2_203638_s_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/7a/PBB_GE_FGFR2_203638_s_at_fs.png/375px-PBB_GE_FGFR2_203638_s_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/7a/PBB_GE_FGFR2_203638_s_at_fs.png/500px-PBB_GE_FGFR2_203638_s_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span><br /><br /><span typeof="mw:File"><a href="/wiki/File:PBB_GE_FGFR2_203639_s_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/e/e2/PBB_GE_FGFR2_203639_s_at_fs.png/250px-PBB_GE_FGFR2_203639_s_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/e/e2/PBB_GE_FGFR2_203639_s_at_fs.png/375px-PBB_GE_FGFR2_203639_s_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/e/e2/PBB_GE_FGFR2_203639_s_at_fs.png/500px-PBB_GE_FGFR2_203639_s_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="http://biogps.org/gene/2263/">More reference expression data</a></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Molecular function</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008201">heparin binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016301">kinase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004714">transmembrane receptor protein tyrosine kinase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0017134">fibroblast growth factor binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005524">ATP binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004672">protein kinase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005007">fibroblast growth factor-activated receptor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016740">transferase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042803">protein homodimerization activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005515">protein binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0000166">nucleotide binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004713">protein tyrosine kinase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016303">1-phosphatidylinositol-3-kinase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0046934">phosphatidylinositol-4,5-bisphosphate 3-kinase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042802">identical protein binding</a></li> <li><a href="https://www.wikidata.org/wiki/Q420511" class="extiw" title="d:Q420511">receptor tyrosine kinase</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004888">transmembrane signaling receptor activity</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Cellular component</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005737">cytoplasm</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016020">membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005576">extracellular region</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005634">nucleus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0009986">cell surface</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016021">integral component of membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005794">Golgi apparatus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043231">intracellular membrane-bounded organelle</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031012">extracellular matrix</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005886">plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005654">nucleoplasm</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005938">cell cortex</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005887">integral component of plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060076">excitatory synapse</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031410">cytoplasmic vesicle</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043235">receptor complex</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0062023">collagen-containing extracellular matrix</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Biological process</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0035607">fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001657">ureteric bud development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0035265">organ growth</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060174">limb bud formation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0009880">embryonic pattern specification</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060449">bud elongation involved in lung branching</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0090263">positive regulation of canonical Wnt signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0003149">membranous septum morphogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0035604">fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048562">embryonic organ morphogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0009791">post-embryonic development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060529">squamous basal epithelial stem cell differentiation involved in prostate gland acinus development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048755">branching morphogenesis of a nerve</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048608">reproductive structure development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0035602">fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0055010">ventricular cardiac muscle tissue morphogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006468">protein phosphorylation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060045">positive regulation of cardiac muscle cell proliferation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048762">mesenchymal cell differentiation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0002053">positive regulation of mesenchymal cell proliferation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045667">regulation of osteoblast differentiation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060527">prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001525">angiogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060512">prostate gland morphogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0070374">positive regulation of ERK1 and ERK2 cascade</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0021769">orbitofrontal cortex development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050680">negative regulation of epithelial cell proliferation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0009887">animal organ morphogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048557">embryonic digestive tract morphogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031069">hair follicle morphogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016331">morphogenesis of embryonic epithelium</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060667">branch elongation involved in salivary gland morphogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006915">apoptotic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060445">branching involved in salivary gland morphogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045165">cell fate commitment</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030324">lung development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048568">embryonic organ development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0035603">fibroblast growth factor receptor signaling pathway involved in hemopoiesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001701">in utero embryonic development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060601">lateral sprouting from an epithelium</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030177">positive regulation of Wnt signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0022612">gland morphogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045787">positive regulation of cell cycle</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060670">branching involved in labyrinthine layer morphogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060442">branching involved in prostate gland morphogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0070372">regulation of ERK1 and ERK2 cascade</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0046777">protein autophosphorylation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060615">mammary gland bud formation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0021860">pyramidal neuron development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032808">lacrimal gland development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043410">positive regulation of MAPK cascade</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051150">regulation of smooth muscle cell differentiation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010453">regulation of cell fate commitment</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030282">bone mineralization</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060687">regulation of branching involved in prostate gland morphogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060501">positive regulation of epithelial cell proliferation involved in lung morphogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030855">epithelial cell differentiation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016310">phosphorylation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0035264">multicellular organism growth</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050679">positive regulation of epithelial cell proliferation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0021847">ventricular zone neuroblast division</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048730">epidermis morphogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048705">skeletal system morphogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060688">regulation of morphogenesis of a branching structure</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0000122">negative regulation of transcription by RNA polymerase II</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0003148">outflow tract septum morphogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042476">odontogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001837">epithelial to mesenchymal transition</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048286">lung alveolus development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060463">lung lobe morphogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030901">midbrain development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048661">positive regulation of smooth muscle cell proliferation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060595">fibroblast growth factor receptor signaling pathway involved in mammary gland specification</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060916">mesenchymal cell proliferation involved in lung development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060523">prostate epithelial cord elongation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060915">mesenchymal cell differentiation involved in lung development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007409">axonogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0040014">regulation of multicellular organism growth</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030916">otic vesicle formation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060664">epithelial cell proliferation involved in salivary gland morphogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007267">cell-cell signaling</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0040036">regulation of fibroblast growth factor receptor signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060349">bone morphogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0000165">MAPK cascade</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0033688">regulation of osteoblast proliferation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010518">positive regulation of phospholipase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008543">fibroblast growth factor receptor signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008589">regulation of smoothened signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042472">inner ear morphogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008284">positive regulation of cell population proliferation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048333">mesodermal cell differentiation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0018108">peptidyl-tyrosine phosphorylation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048565">digestive tract development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060484">lung-associated mesenchyme development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060348">bone development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051781">positive regulation of cell division</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045944">positive regulation of transcription by RNA polymerase II</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0046854">phosphatidylinositol phosphate biosynthetic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0036092">phosphatidylinositol-3-phosphate biosynthetic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0003416">endochondral bone growth</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032496">response to lipopolysaccharide</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042060">wound healing</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0044344">cellular response to fibroblast growth factor stimulus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045471">response to ethanol</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0071300">cellular response to retinoic acid</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0071560">cellular response to transforming growth factor beta stimulus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048701">embryonic cranial skeleton morphogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051897">positive regulation of protein kinase B signaling</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0009968">negative regulation of signal transduction</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030154">cell differentiation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043066">negative regulation of apoptotic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007169">transmembrane receptor protein tyrosine kinase signaling pathway</a></li></ul> </div></td></tr><tr><td colspan="4" style="background-color:#eee;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:#c3fdb8">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=2263&rn=1">2263</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=14183&rn=1">14183</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000066468;db=core">ENSG00000066468</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000030849;db=core">ENSMUSG00000030849</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P21802">P21802</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P21803">P21803</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (mRNA)</th><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_000141">NM_000141</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001144913">NM_001144913</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001144914">NM_001144914</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001144915">NM_001144915</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001144916">NM_001144916</a><br /></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001144917">NM_001144917</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001144918">NM_001144918</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001144919">NM_001144919</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_022970">NM_022970</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_022971">NM_022971</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_022972">NM_022972</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_022973">NM_022973</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_022974">NM_022974</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_022975">NM_022975</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_022976">NM_022976</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_023028">NM_023028</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_023029">NM_023029</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_023030">NM_023030</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001320654">NM_001320654</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001320658">NM_001320658</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_023031">NM_023031</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_010207">NM_010207</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_201601">NM_201601</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001347638">NM_001347638</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (protein)</th><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_000132">NP_000132</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001138385">NP_001138385</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001138386">NP_001138386</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001138387">NP_001138387</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001138388">NP_001138388</a><br /></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001138389">NP_001138389</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001138390">NP_001138390</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001138391">NP_001138391</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001307583">NP_001307583</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001307587">NP_001307587</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_075259">NP_075259</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_075418">NP_075418</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001334567">NP_001334567</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_034337">NP_034337</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_963895">NP_963895</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">Location (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr10:121478332-121598458">Chr 10: 121.48 – 121.6 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr7:129764181-132725079">Chr 7: 129.76 – 132.73 Mb</a></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q14911644" class="extiw" title="d:Q14911644">View/Edit Human</a></td><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q14911645" class="extiw" title="d:Q14911645">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table> <p><b>Fibroblast growth factor receptor 2</b> (<b>FGFR-2</b>) also known as <b>CD332</b> (<a href="/wiki/Cluster_of_differentiation" title="Cluster of differentiation">cluster of differentiation</a> 332) is a <a href="/wiki/Protein" title="Protein">protein</a> that in humans is encoded by the <i>FGFR2</i> <a href="/wiki/Gene" title="Gene">gene</a> residing on <a href="/wiki/Chromosome_10" title="Chromosome 10">chromosome 10</a>.<sup id="cite_ref-pmid2172978_5-0" class="reference"><a href="#cite_note-pmid2172978-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid1697263_6-0" class="reference"><a href="#cite_note-pmid1697263-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> FGFR2 is a receptor for <a href="/wiki/Fibroblast_growth_factor" title="Fibroblast growth factor">fibroblast growth factor</a>. </p><p>FGFR-2 is a member of the <a href="/wiki/Fibroblast_growth_factor_receptor" title="Fibroblast growth factor receptor">fibroblast growth factor receptor</a> family, where amino acid sequence is highly conserved between members and throughout evolution.<sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three <a href="/wiki/Immunoglobulin_domain" title="Immunoglobulin domain">immunoglobulin domains</a>, a single <a href="/wiki/Hydrophone" title="Hydrophone">hydrophobic</a> membrane-spanning segment and a <a href="/wiki/Cytoplasm" title="Cytoplasm">cytoplasmic</a> <a href="/wiki/Tyrosine_kinase" title="Tyrosine kinase">tyrosine kinase</a> domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing <a href="/wiki/Mitogenesis" class="mw-redirect" title="Mitogenesis">mitogenesis</a> and <a href="/wiki/Cellular_differentiation" title="Cellular differentiation">differentiation</a>. This particular family member is a high-affinity receptor for acidic, basic and/or <a href="/wiki/Keratinocyte" title="Keratinocyte">keratinocyte</a> growth factor, depending on the <a href="/wiki/Isoform" class="mw-redirect" title="Isoform">isoform</a>. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Function">Function</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Fibroblast_growth_factor_receptor_2&action=edit&section=1" title="Edit section: Function"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>FGFR2 has important roles in embryonic development and tissue repair, especially bone and blood vessels. Like the other members of the <a href="/wiki/Fibroblast_growth_factor_receptor" title="Fibroblast growth factor receptor">fibroblast growth factor receptor</a> family, these <a href="/wiki/Receptor_(biochemistry)" title="Receptor (biochemistry)">receptors</a> signal by binding to their <a href="/wiki/Ligand" title="Ligand">ligand</a> and <a href="/wiki/Dimer_(chemistry)" class="mw-redirect" title="Dimer (chemistry)">dimerisation</a> (pairing of receptors), which causes the tyrosine kinase domains to initiate a cascade of intracellular signals. On a molecular level these signals mediate cell division, growth and differentiation. </p> <div class="mw-heading mw-heading2"><h2 id="Isoforms">Isoforms</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Fibroblast_growth_factor_receptor_2&action=edit&section=2" title="Edit section: Isoforms"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>FGFR2 has two naturally occurring isoforms, FGFR2IIIb and FGFR2IIIc, created by splicing of the third immunoglobulin-like domain. FGFR2IIIb is predominantly found in <a href="/wiki/Ectoderm" title="Ectoderm">ectoderm</a> derived tissues and <a href="/wiki/Endothelium" title="Endothelium">endothelial</a> organ lining, i.e. skin and internal organs.<sup id="cite_ref-pmid8393815_8-0" class="reference"><a href="#cite_note-pmid8393815-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> FGFR2IIIc is found in <a href="/wiki/Mesenchyme" title="Mesenchyme">mesenchyme</a>, which includes <a href="/wiki/Craniofacial" class="mw-redirect" title="Craniofacial">craniofacial</a> bone and for this reason the mutations of this gene and isoform are associated with <a href="/wiki/Craniosynostosis" title="Craniosynostosis">craniosynostosis</a>. </p> <div class="mw-heading mw-heading2"><h2 id="Interactions">Interactions</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Fibroblast_growth_factor_receptor_2&action=edit&section=3" title="Edit section: Interactions"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Fibroblast growth factor receptor 2 has been shown to <a href="/wiki/Protein-protein_interaction" class="mw-redirect" title="Protein-protein interaction">interact</a> with <a href="/wiki/FGF1" class="mw-redirect" title="FGF1">FGF1</a>.<sup id="cite_ref-pmid10618369_9-0" class="reference"><a href="#cite_note-pmid10618369-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid11069186_10-0" class="reference"><a href="#cite_note-pmid11069186-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid8576175_11-0" class="reference"><a href="#cite_note-pmid8576175-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> </p><p>The spliced isoforms, however differ in binding:<sup id="cite_ref-pmid8663044_12-0" class="reference"><a href="#cite_note-pmid8663044-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> </p> <ul><li>FGFR2IIIb binds to <a href="/wiki/FGF1" class="mw-redirect" title="FGF1">FGF-1</a>, <a href="/wiki/FGF3" title="FGF3">-3</a>, <a href="/wiki/FGF7" title="FGF7">-7</a>, <a href="/wiki/FGF10" title="FGF10">-10</a>, <a href="/wiki/FGF22" title="FGF22">-22</a></li> <li>FGFR2IIIc binds to FGF-1, <a href="/wiki/Basic_fibroblast_growth_factor" class="mw-redirect" title="Basic fibroblast growth factor">-2</a>, <a href="/wiki/FGF4" title="FGF4">-4</a>, <a href="/wiki/FGF6" title="FGF6">-6</a>, <a href="/wiki/FGF8" class="mw-redirect" title="FGF8">-8</a>, <a href="/wiki/FGF9" title="FGF9">-9</a>, <a href="/wiki/FGF17" title="FGF17">-17</a> and <a href="/wiki/FGF18" title="FGF18">-18</a></li></ul> <p>These differences in binding are not surprising, since FGF ligand is known to bind to the second and third <a href="/wiki/Immunoglobulin_domain" title="Immunoglobulin domain">immunoglobulin domain</a> of the receptor. </p> <div class="mw-heading mw-heading2"><h2 id="Clinical_significance">Clinical significance</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Fibroblast_growth_factor_receptor_2&action=edit&section=4" title="Edit section: Clinical significance"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Mutations (changes) are associated with numerous medical conditions that include abnormal bone development (e.g. craniosynostosis syndromes) and cancer. </p> <div class="mw-heading mw-heading3"><h3 id="Craniosynostosis_syndromes">Craniosynostosis syndromes</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Fibroblast_growth_factor_receptor_2&action=edit&section=5" title="Edit section: Craniosynostosis syndromes"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>FGFR2 mutations are the cause of several <a href="/wiki/Craniosynostosis" title="Craniosynostosis">craniosynostosis</a> syndromes:<sup id="cite_ref-13" class="reference"><a href="#cite_note-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> </p> <ul><li>Acrocephalosyndactyly type 1 (<a href="/wiki/Apert_syndrome" title="Apert syndrome">Apert syndrome</a>)</li> <li><a href="/wiki/Beare%E2%80%93Stevenson_cutis_gyrata_syndrome" title="Beare–Stevenson cutis gyrata syndrome">Beare-Stevenson cutis gyrata syndrome</a></li> <li><a href="/wiki/Crouzon_syndrome" title="Crouzon syndrome">Crouzon syndrome</a></li> <li><a href="/wiki/Jackson%E2%80%93Weiss_syndrome" title="Jackson–Weiss syndrome">Jackson-Weiss syndrome</a></li> <li><a href="/wiki/Pfeiffer_syndrome" title="Pfeiffer syndrome">Pfeiffer syndrome</a></li></ul> <div class="mw-heading mw-heading3"><h3 id="Cancer">Cancer</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Fibroblast_growth_factor_receptor_2&action=edit&section=6" title="Edit section: Cancer"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Breast_cancer" title="Breast cancer">Breast cancer</a>, a mutation or <a href="/wiki/Single_nucleotide_polymorphism" class="mw-redirect" title="Single nucleotide polymorphism">single nucleotide polymorphism</a> (SNP) in <a href="/wiki/Intron" title="Intron">intron</a> 2 of the FGFR2 <a href="/wiki/Gene" title="Gene">gene</a> is associated with a higher breast cancer risk; however the risk is only mildly increased from about 10% lifetime breast cancer risk in the average woman in the industrialized world, to 12-14% risk in carriers of the SNP.<sup id="cite_ref-14" class="reference"><a href="#cite_note-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup></li></ul> <p>Missense mutations of FGFR2 have been found in <a href="/wiki/Endometrial_cancer" title="Endometrial cancer">endometrial cancer</a> and <a href="/wiki/Melanoma" title="Melanoma">melanoma</a>.<sup id="cite_ref-Katoh_2014_15-0" class="reference"><a href="#cite_note-Katoh_2014-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="As_a_drug_target">As a drug target</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Fibroblast_growth_factor_receptor_2&action=edit&section=7" title="Edit section: As a drug target"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>AZD4547 is a tyrosine kinase inhibitor which targets FGFR1-3. It has demonstrated early evidence of efficacy in <a href="/wiki/Gastric_cancer" class="mw-redirect" title="Gastric cancer">gastric cancer</a> patients with high level FGFR2 amplification (Cancer Discovery 2016). <a href="/w/index.php?title=FPA144&action=edit&redlink=1" class="new" title="FPA144 (page does not exist)">FPA144</a> is a <a href="/wiki/Monoclonal_antibody" title="Monoclonal antibody">monoclonal antibody</a> that binds to FGFR2b (a form of FGFR2) and preventing binding of certain FGFs. In 2014, a clinical trial began to treat gastric tumours that overexpress FGFR2b.<sup id="cite_ref-16" class="reference"><a href="#cite_note-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> Another approach of FGFR2 targeting is use of <a href="/wiki/Allosteric_inhibitor" class="mw-redirect" title="Allosteric inhibitor">allosteric inhibitors</a>. <a href="/w/index.php?title=Alofanib&action=edit&redlink=1" class="new" title="Alofanib (page does not exist)">Alofanib</a> is a novel first-in-class allosteric small-molecular inhibitor of FGFR2. It binds to the extracellular domain of FGFR2 and has an inhibitory effect on FGF2-induced <a href="/wiki/Phosphorylation" title="Phosphorylation">phosphorylation</a>. Principal benefits of allosteric inhibitors are high selectivity and low <a href="/wiki/Toxicity" title="Toxicity">toxicity</a> [Tsimafeyeu et al. ESMO Asia 2016]. A phase Ib clinical study protocol has been selected for ECCO-AACR-EORTC-ESMO Workshop on Methods in Clinical Cancer Research, better known as the ‘Flims’ Workshop and clinical study of safety and preliminary efficacy of alofanib will be initiated at the beginning of 2017. </p> <div class="mw-heading mw-heading2"><h2 id="Mutations">Mutations</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Fibroblast_growth_factor_receptor_2&action=edit&section=8" title="Edit section: Mutations"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>FGFR2 mutations are associated with <a href="/wiki/Craniosynostosis" title="Craniosynostosis">craniosynostosis</a> syndromes, which are skull malformations caused by premature fusion of cranial sutures and other disease features according to the mutation itself. Analysis of chromosomal anomalies in patients led to the identification and confirmation of FGFR2 as a cleft lip and/or palate locus.<sup id="cite_ref-17" class="reference"><a href="#cite_note-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> On a molecular level, mutations that affect FGFR2IIIc are associated with marked changes in <a href="/wiki/Osteoblast" title="Osteoblast">osteoblast</a> proliferation and differentiation.<sup id="cite_ref-pmid20004243_18-0" class="reference"><a href="#cite_note-pmid20004243-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup> Alteration in FGFR2 signalling is thought to underlie the craniosynostosis syndromes. To date, there are two mechanisms of altered FGFR2 signalling. The first is associated with constitutive activation of FGFR, where the FGFR2 receptor is always signalling, regardless of the amount of FGF ligand.<sup id="cite_ref-pmid9315632_19-0" class="reference"><a href="#cite_note-pmid9315632-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> This mechanism is found in patients with Crouzon and Pfeiffer syndrome. The second, which is associated with Apert syndrome is a loss of specificity of the FGFR2 isoform, resulting in the receptor binding to FGFs that it does not normally bind.<sup id="cite_ref-pmid18773495_20-0" class="reference"><a href="#cite_note-pmid18773495-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Fibroblast_growth_factor_receptor_2&action=edit&section=9" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Cluster_of_differentiation" title="Cluster of differentiation">Cluster of differentiation</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Fibroblast_growth_factor_receptor_2&action=edit&section=10" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist reflist-columns references-column-width" style="column-width: 33em;"> <ol class="references"> <li id="cite_note-refGRCh38Ensembl-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCh38Ensembl_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000066468">GRCh38: Ensembl release 89: ENSG00000066468</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-refGRCm38Ensembl-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCm38Ensembl_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000030849">GRCm38: Ensembl release 89: ENSMUSG00000030849</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=2263">"Human PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=National+Center+for+Biotechnology+Information%2C+U.S.+National+Library+of+Medicine&rft.atitle=Human+PubMed+Reference%3A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fdb%3Dgene%26cmd%3DLink%26LinkName%3Dgene_pubmed%26from_uid%3D2263&rfr_id=info%3Asid%2Fen.wikipedia.org%3AFibroblast+growth+factor+receptor+2" class="Z3988"></span></span> </li> <li id="cite_note-4"><span class="mw-cite-backlink"><b><a href="#cite_ref-4">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=14183">"Mouse PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=National+Center+for+Biotechnology+Information%2C+U.S.+National+Library+of+Medicine&rft.atitle=Mouse+PubMed+Reference%3A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fdb%3Dgene%26cmd%3DLink%26LinkName%3Dgene_pubmed%26from_uid%3D14183&rfr_id=info%3Asid%2Fen.wikipedia.org%3AFibroblast+growth+factor+receptor+2" class="Z3988"></span></span> </li> <li id="cite_note-pmid2172978-5"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid2172978_5-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFHoussaintBlanquetChampion-ArnaudGesnel1990" class="citation journal cs1">Houssaint E, Blanquet PR, Champion-Arnaud P, Gesnel MC, Torriglia A, Courtois Y, Breathnach R (Oct 1990). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC54916">"Related fibroblast growth factor receptor genes exist in the human genome"</a>. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. <b>87</b> (20): 8180–4. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/1990PNAS...87.8180H">1990PNAS...87.8180H</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1073%2Fpnas.87.20.8180">10.1073/pnas.87.20.8180</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC54916">54916</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/2172978">2172978</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Related+fibroblast+growth+factor+receptor+genes+exist+in+the+human+genome&rft.volume=87&rft.issue=20&rft.pages=8180-4&rft.date=1990-10&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC54916%23id-name%3DPMC&rft_id=info%3Apmid%2F2172978&rft_id=info%3Adoi%2F10.1073%2Fpnas.87.20.8180&rft_id=info%3Abibcode%2F1990PNAS...87.8180H&rft.aulast=Houssaint&rft.aufirst=E&rft.au=Blanquet%2C+PR&rft.au=Champion-Arnaud%2C+P&rft.au=Gesnel%2C+MC&rft.au=Torriglia%2C+A&rft.au=Courtois%2C+Y&rft.au=Breathnach%2C+R&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC54916&rfr_id=info%3Asid%2Fen.wikipedia.org%3AFibroblast+growth+factor+receptor+2" class="Z3988"></span></span> </li> <li id="cite_note-pmid1697263-6"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid1697263_6-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFDionneCrumleyBellotKaplow1990" class="citation journal cs1">Dionne CA, Crumley G, Bellot F, Kaplow JM, Searfoss G, Ruta M, Burgess WH, Jaye M, Schlessinger J (Sep 1990). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC551973">"Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors"</a>. <i>The EMBO Journal</i>. <b>9</b> (9): 2685–92. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fj.1460-2075.1990.tb07454.x">10.1002/j.1460-2075.1990.tb07454.x</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC551973">551973</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/1697263">1697263</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+EMBO+Journal&rft.atitle=Cloning+and+expression+of+two+distinct+high-affinity+receptors+cross-reacting+with+acidic+and+basic+fibroblast+growth+factors&rft.volume=9&rft.issue=9&rft.pages=2685-92&rft.date=1990-09&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC551973%23id-name%3DPMC&rft_id=info%3Apmid%2F1697263&rft_id=info%3Adoi%2F10.1002%2Fj.1460-2075.1990.tb07454.x&rft.aulast=Dionne&rft.aufirst=CA&rft.au=Crumley%2C+G&rft.au=Bellot%2C+F&rft.au=Kaplow%2C+JM&rft.au=Searfoss%2C+G&rft.au=Ruta%2C+M&rft.au=Burgess%2C+WH&rft.au=Jaye%2C+M&rft.au=Schlessinger%2C+J&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC551973&rfr_id=info%3Asid%2Fen.wikipedia.org%3AFibroblast+growth+factor+receptor+2" class="Z3988"></span></span> </li> <li id="cite_note-7"><span class="mw-cite-backlink"><b><a href="#cite_ref-7">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2263">"Entrez Gene: FGFR2 fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson–Weiss syndrome)"</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Entrez+Gene%3A+FGFR2+fibroblast+growth+factor+receptor+2+%28bacteria-expressed+kinase%2C+keratinocyte+growth+factor+receptor%2C+craniofacial+dysostosis+1%2C+Crouzon+syndrome%2C+Pfeiffer+syndrome%2C+Jackson%E2%80%93Weiss+syndrome%29&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3FDb%3Dgene%26Cmd%3DShowDetailView%26TermToSearch%3D2263&rfr_id=info%3Asid%2Fen.wikipedia.org%3AFibroblast+growth+factor+receptor+2" class="Z3988"></span></span> </li> <li id="cite_note-pmid8393815-8"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid8393815_8-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFOrr-UrtregerBedfordBurakovaArman1993" class="citation journal cs1">Orr-Urtreger A, Bedford MT, Burakova T, Arman E, Zimmer Y, Yayon A, Givol D, Lonai P (Aug 1993). "Developmental localization of the splicing alternatives of fibroblast growth factor receptor-2 (FGFR2)". <i>Developmental Biology</i>. <b>158</b> (2): 475–86. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1006%2Fdbio.1993.1205">10.1006/dbio.1993.1205</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/8393815">8393815</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Developmental+Biology&rft.atitle=Developmental+localization+of+the+splicing+alternatives+of+fibroblast+growth+factor+receptor-2+%28FGFR2%29&rft.volume=158&rft.issue=2&rft.pages=475-86&rft.date=1993-08&rft_id=info%3Adoi%2F10.1006%2Fdbio.1993.1205&rft_id=info%3Apmid%2F8393815&rft.aulast=Orr-Urtreger&rft.aufirst=A&rft.au=Bedford%2C+MT&rft.au=Burakova%2C+T&rft.au=Arman%2C+E&rft.au=Zimmer%2C+Y&rft.au=Yayon%2C+A&rft.au=Givol%2C+D&rft.au=Lonai%2C+P&rfr_id=info%3Asid%2Fen.wikipedia.org%3AFibroblast+growth+factor+receptor+2" class="Z3988"></span></span> </li> <li id="cite_note-pmid10618369-9"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid10618369_9-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFStauberDiGabrieleHendrickson2000" class="citation journal cs1">Stauber DJ, DiGabriele AD, Hendrickson WA (Jan 2000). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC26614">"Structural interactions of fibroblast growth factor receptor with its ligands"</a>. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. <b>97</b> (1): 49–54. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2000PNAS...97...49S">2000PNAS...97...49S</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1073%2Fpnas.97.1.49">10.1073/pnas.97.1.49</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC26614">26614</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10618369">10618369</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Structural+interactions+of+fibroblast+growth+factor+receptor+with+its+ligands&rft.volume=97&rft.issue=1&rft.pages=49-54&rft.date=2000-01&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC26614%23id-name%3DPMC&rft_id=info%3Apmid%2F10618369&rft_id=info%3Adoi%2F10.1073%2Fpnas.97.1.49&rft_id=info%3Abibcode%2F2000PNAS...97...49S&rft.aulast=Stauber&rft.aufirst=DJ&rft.au=DiGabriele%2C+AD&rft.au=Hendrickson%2C+WA&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC26614&rfr_id=info%3Asid%2Fen.wikipedia.org%3AFibroblast+growth+factor+receptor+2" class="Z3988"></span></span> </li> <li id="cite_note-pmid11069186-10"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid11069186_10-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFPellegriniBurkevon_DelftMulloy2000" class="citation journal cs1">Pellegrini L, Burke DF, von Delft F, Mulloy B, Blundell TL (Oct 2000). "Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin". <i>Nature</i>. <b>407</b> (6807): 1029–34. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2000Natur.407.1029P">2000Natur.407.1029P</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2F35039551">10.1038/35039551</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11069186">11069186</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:4418272">4418272</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Crystal+structure+of+fibroblast+growth+factor+receptor+ectodomain+bound+to+ligand+and+heparin&rft.volume=407&rft.issue=6807&rft.pages=1029-34&rft.date=2000-10&rft_id=info%3Adoi%2F10.1038%2F35039551&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A4418272%23id-name%3DS2CID&rft_id=info%3Apmid%2F11069186&rft_id=info%3Abibcode%2F2000Natur.407.1029P&rft.aulast=Pellegrini&rft.aufirst=L&rft.au=Burke%2C+DF&rft.au=von+Delft%2C+F&rft.au=Mulloy%2C+B&rft.au=Blundell%2C+TL&rfr_id=info%3Asid%2Fen.wikipedia.org%3AFibroblast+growth+factor+receptor+2" class="Z3988"></span></span> </li> <li id="cite_note-pmid8576175-11"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid8576175_11-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSantos-OcampoColvinChellaiahOrnitz1996" class="citation journal cs1">Santos-Ocampo S, Colvin JS, Chellaiah A, Ornitz DM (Jan 1996). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.271.3.1726">"Expression and biological activity of mouse fibroblast growth factor-9"</a>. <i>The Journal of Biological Chemistry</i>. <b>271</b> (3): 1726–31. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.271.3.1726">10.1074/jbc.271.3.1726</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/8576175">8576175</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:27191391">27191391</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=Expression+and+biological+activity+of+mouse+fibroblast+growth+factor-9&rft.volume=271&rft.issue=3&rft.pages=1726-31&rft.date=1996-01&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A27191391%23id-name%3DS2CID&rft_id=info%3Apmid%2F8576175&rft_id=info%3Adoi%2F10.1074%2Fjbc.271.3.1726&rft.aulast=Santos-Ocampo&rft.aufirst=S&rft.au=Colvin%2C+JS&rft.au=Chellaiah%2C+A&rft.au=Ornitz%2C+DM&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.271.3.1726&rfr_id=info%3Asid%2Fen.wikipedia.org%3AFibroblast+growth+factor+receptor+2" class="Z3988"></span></span> </li> <li id="cite_note-pmid8663044-12"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid8663044_12-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFOrnitzXuColvinMcEwen1996" class="citation journal cs1">Ornitz DM, Xu J, Colvin JS, McEwen DG, MacArthur CA, Coulier F, Gao G, Goldfarb M (Jun 1996). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.271.25.15292">"Receptor specificity of the fibroblast growth factor family"</a>. <i>The Journal of Biological Chemistry</i>. <b>271</b> (25): 15292–7. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.271.25.15292">10.1074/jbc.271.25.15292</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/8663044">8663044</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:31736768">31736768</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=Receptor+specificity+of+the+fibroblast+growth+factor+family&rft.volume=271&rft.issue=25&rft.pages=15292-7&rft.date=1996-06&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A31736768%23id-name%3DS2CID&rft_id=info%3Apmid%2F8663044&rft_id=info%3Adoi%2F10.1074%2Fjbc.271.25.15292&rft.aulast=Ornitz&rft.aufirst=DM&rft.au=Xu%2C+J&rft.au=Colvin%2C+JS&rft.au=McEwen%2C+DG&rft.au=MacArthur%2C+CA&rft.au=Coulier%2C+F&rft.au=Gao%2C+G&rft.au=Goldfarb%2C+M&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.271.25.15292&rfr_id=info%3Asid%2Fen.wikipedia.org%3AFibroblast+growth+factor+receptor+2" class="Z3988"></span></span> </li> <li id="cite_note-13"><span class="mw-cite-backlink"><b><a href="#cite_ref-13">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/medgen/850742">"FGFR2-related craniosynostosis (Concept Id: CN231480)"</a>. <i>www.ncbi.nlm.nih.gov</i><span class="reference-accessdate">. Retrieved <span class="nowrap">2023-07-17</span></span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=www.ncbi.nlm.nih.gov&rft.atitle=FGFR2-related+craniosynostosis+%28Concept+Id%3A+CN231480%29&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fmedgen%2F850742&rfr_id=info%3Asid%2Fen.wikipedia.org%3AFibroblast+growth+factor+receptor+2" class="Z3988"></span></span> </li> <li id="cite_note-14"><span class="mw-cite-backlink"><b><a href="#cite_ref-14">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFHunterKraftJacobsCox2007" class="citation journal cs1">Hunter DJ, Kraft P, Jacobs KB, Cox DG, Yeager M, Hankinson SE, Wacholder S, Wang Z, Welch R, Hutchinson A, Wang J, Yu K, Chatterjee N, Orr N, Willett WC, Colditz GA, Ziegler RG, Berg CD, Buys SS, McCarty CA, Feigelson HS, Calle EE, Thun MJ, Hayes RB, Tucker M, Gerhard DS, Fraumeni JF, Hoover RN, Thomas G, Chanock SJ (Jul 2007). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493132">"A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer"</a>. <i>Nature Genetics</i>. <b>39</b> (7): 870–4. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fng2075">10.1038/ng2075</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493132">3493132</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17529973">17529973</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nature+Genetics&rft.atitle=A+genome-wide+association+study+identifies+alleles+in+FGFR2+associated+with+risk+of+sporadic+postmenopausal+breast+cancer&rft.volume=39&rft.issue=7&rft.pages=870-4&rft.date=2007-07&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3493132%23id-name%3DPMC&rft_id=info%3Apmid%2F17529973&rft_id=info%3Adoi%2F10.1038%2Fng2075&rft.aulast=Hunter&rft.aufirst=DJ&rft.au=Kraft%2C+P&rft.au=Jacobs%2C+KB&rft.au=Cox%2C+DG&rft.au=Yeager%2C+M&rft.au=Hankinson%2C+SE&rft.au=Wacholder%2C+S&rft.au=Wang%2C+Z&rft.au=Welch%2C+R&rft.au=Hutchinson%2C+A&rft.au=Wang%2C+J&rft.au=Yu%2C+K&rft.au=Chatterjee%2C+N&rft.au=Orr%2C+N&rft.au=Willett%2C+WC&rft.au=Colditz%2C+GA&rft.au=Ziegler%2C+RG&rft.au=Berg%2C+CD&rft.au=Buys%2C+SS&rft.au=McCarty%2C+CA&rft.au=Feigelson%2C+HS&rft.au=Calle%2C+EE&rft.au=Thun%2C+MJ&rft.au=Hayes%2C+RB&rft.au=Tucker%2C+M&rft.au=Gerhard%2C+DS&rft.au=Fraumeni%2C+JF&rft.au=Hoover%2C+RN&rft.au=Thomas%2C+G&rft.au=Chanock%2C+SJ&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3493132&rfr_id=info%3Asid%2Fen.wikipedia.org%3AFibroblast+growth+factor+receptor+2" class="Z3988"></span></span> </li> <li id="cite_note-Katoh_2014-15"><span class="mw-cite-backlink"><b><a href="#cite_ref-Katoh_2014_15-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKatohNakagama2014" class="citation journal cs1">Katoh M, Nakagama H (Mar 2014). "FGF receptors: cancer biology and therapeutics". <i>Medicinal Research Reviews</i>. <b>34</b> (2): 280–300. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fmed.21288">10.1002/med.21288</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/23696246">23696246</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:27412585">27412585</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Medicinal+Research+Reviews&rft.atitle=FGF+receptors%3A+cancer+biology+and+therapeutics&rft.volume=34&rft.issue=2&rft.pages=280-300&rft.date=2014-03&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A27412585%23id-name%3DS2CID&rft_id=info%3Apmid%2F23696246&rft_id=info%3Adoi%2F10.1002%2Fmed.21288&rft.aulast=Katoh&rft.aufirst=M&rft.au=Nakagama%2C+H&rfr_id=info%3Asid%2Fen.wikipedia.org%3AFibroblast+growth+factor+receptor+2" class="Z3988"></span></span> </li> <li id="cite_note-16"><span class="mw-cite-backlink"><b><a href="#cite_ref-16">^</a></b></span> <span class="reference-text"><a rel="nofollow" class="external text" href="https://clinicaltrials.gov/ct2/show/NCT02318329">Open-Label, Dose-Finding Study Evaluating Safety and PK of FPA144 in Patients With Advanced Solid Tumors</a></span> </li> <li id="cite_note-17"><span class="mw-cite-backlink"><b><a href="#cite_ref-17">^</a></b></span> <span class="reference-text">Dixon MJ, Marazita ML, Beaty TH, Murray JC (2011). "Cleft lip and palate: understanding genetic and environmental influences". Nature Review Genetics (12): 167-178.</span> </li> <li id="cite_note-pmid20004243-18"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid20004243_18-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFLeeSantos-RuizFerretti2010" class="citation journal cs1">Lee KM, Santos-Ruiz L, Ferretti P (Mar 2010). <a rel="nofollow" class="external text" href="https://hal.archives-ouvertes.fr/hal-00560299/file/PEER_stage2_10.1016%252Fj.bbadis.2009.11.006.pdf">"A single-point mutation in FGFR2 affects cell cycle and Tgfbeta signalling in osteoblasts"</a> <span class="cs1-format">(PDF)</span>. <i>Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease</i>. <b>1802</b> (3): 347–55. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.bbadis.2009.11.006">10.1016/j.bbadis.2009.11.006</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/20004243">20004243</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Biochimica+et+Biophysica+Acta+%28BBA%29+-+Molecular+Basis+of+Disease&rft.atitle=A+single-point+mutation+in+FGFR2+affects+cell+cycle+and+Tgfbeta+signalling+in+osteoblasts&rft.volume=1802&rft.issue=3&rft.pages=347-55&rft.date=2010-03&rft_id=info%3Adoi%2F10.1016%2Fj.bbadis.2009.11.006&rft_id=info%3Apmid%2F20004243&rft.aulast=Lee&rft.aufirst=KM&rft.au=Santos-Ruiz%2C+L&rft.au=Ferretti%2C+P&rft_id=https%3A%2F%2Fhal.archives-ouvertes.fr%2Fhal-00560299%2Ffile%2FPEER_stage2_10.1016%25252Fj.bbadis.2009.11.006.pdf&rfr_id=info%3Asid%2Fen.wikipedia.org%3AFibroblast+growth+factor+receptor+2" class="Z3988"></span></span> </li> <li id="cite_note-pmid9315632-19"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid9315632_19-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWebsterDonoghue1997" class="citation journal cs1">Webster MK, Donoghue DJ (Oct 1997). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC232422">"Enhanced signaling and morphological transformation by a membrane-localized derivative of the fibroblast growth factor receptor 3 kinase domain"</a>. <i>Molecular and Cellular Biology</i>. <b>17</b> (10): 5739–47. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1128%2Fmcb.17.10.5739">10.1128/mcb.17.10.5739</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC232422">232422</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9315632">9315632</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Molecular+and+Cellular+Biology&rft.atitle=Enhanced+signaling+and+morphological+transformation+by+a+membrane-localized+derivative+of+the+fibroblast+growth+factor+receptor+3+kinase+domain&rft.volume=17&rft.issue=10&rft.pages=5739-47&rft.date=1997-10&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC232422%23id-name%3DPMC&rft_id=info%3Apmid%2F9315632&rft_id=info%3Adoi%2F10.1128%2Fmcb.17.10.5739&rft.aulast=Webster&rft.aufirst=MK&rft.au=Donoghue%2C+DJ&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC232422&rfr_id=info%3Asid%2Fen.wikipedia.org%3AFibroblast+growth+factor+receptor+2" class="Z3988"></span></span> </li> <li id="cite_note-pmid18773495-20"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid18773495_20-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFHajihosseiniDuartePegrumDonjacour2009" class="citation journal cs1">Hajihosseini MK, Duarte R, Pegrum J, Donjacour A, Lana-Elola E, Rice DP, Sharpe J, Dickson C (Feb 2009). <a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fdvdy.21648">"Evidence that Fgf10 contributes to the skeletal and visceral defects of an Apert syndrome mouse model"</a>. <i>Developmental Dynamics</i>. <b>238</b> (2): 376–85. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fdvdy.21648">10.1002/dvdy.21648</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/18773495">18773495</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:39997577">39997577</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Developmental+Dynamics&rft.atitle=Evidence+that+Fgf10+contributes+to+the+skeletal+and+visceral+defects+of+an+Apert+syndrome+mouse+model&rft.volume=238&rft.issue=2&rft.pages=376-85&rft.date=2009-02&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A39997577%23id-name%3DS2CID&rft_id=info%3Apmid%2F18773495&rft_id=info%3Adoi%2F10.1002%2Fdvdy.21648&rft.aulast=Hajihosseini&rft.aufirst=MK&rft.au=Duarte%2C+R&rft.au=Pegrum%2C+J&rft.au=Donjacour%2C+A&rft.au=Lana-Elola%2C+E&rft.au=Rice%2C+DP&rft.au=Sharpe%2C+J&rft.au=Dickson%2C+C&rft_id=https%3A%2F%2Fdoi.org%2F10.1002%252Fdvdy.21648&rfr_id=info%3Asid%2Fen.wikipedia.org%3AFibroblast+growth+factor+receptor+2" class="Z3988"></span></span> </li> </ol></div> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Fibroblast_growth_factor_receptor_2&action=edit&section=11" title="Edit section: Further reading"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin refbegin-columns references-column-width" style="column-width: 33em"> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMcKeehanKan1994" class="citation journal cs1">McKeehan WL, Kan M (Sep 1994). "Heparan sulfate fibroblast growth factor receptor complex: structure-function relationships". <i>Molecular Reproduction and Development</i>. <b>39</b> (1): 69–81, discussion 81–2. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fmrd.1080390112">10.1002/mrd.1080390112</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/7999363">7999363</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:6471340">6471340</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Molecular+Reproduction+and+Development&rft.atitle=Heparan+sulfate+fibroblast+growth+factor+receptor+complex%3A+structure-function+relationships&rft.volume=39&rft.issue=1&rft.pages=69-81%2C+discussion+81-2&rft.date=1994-09&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A6471340%23id-name%3DS2CID&rft_id=info%3Apmid%2F7999363&rft_id=info%3Adoi%2F10.1002%2Fmrd.1080390112&rft.aulast=McKeehan&rft.aufirst=WL&rft.au=Kan%2C+M&rfr_id=info%3Asid%2Fen.wikipedia.org%3AFibroblast+growth+factor+receptor+2" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFJohnsonWilliams1993" class="citation book cs1">Johnson DE, Williams LT (1993). <i>Structural and functional diversity in the FGF receptor multigene family</i>. Advances in Cancer Research. Vol. 60. pp. 1–41. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0065-230X%2808%2960821-0">10.1016/S0065-230X(08)60821-0</a>. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-0-12-006660-5" title="Special:BookSources/978-0-12-006660-5"><bdi>978-0-12-006660-5</bdi></a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/8417497">8417497</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Structural+and+functional+diversity+in+the+FGF+receptor+multigene+family&rft.series=Advances+in+Cancer+Research&rft.pages=1-41&rft.date=1993&rft_id=info%3Apmid%2F8417497&rft_id=info%3Adoi%2F10.1016%2FS0065-230X%2808%2960821-0&rft.isbn=978-0-12-006660-5&rft.aulast=Johnson&rft.aufirst=DE&rft.au=Williams%2C+LT&rfr_id=info%3Asid%2Fen.wikipedia.org%3AFibroblast+growth+factor+receptor+2" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFParkMeyersLiTheda1995" class="citation journal cs1">Park WJ, Meyers GA, Li X, Theda C, Day D, Orlow SJ, Jones MC, Jabs EW (Jul 1995). "Novel FGFR2 mutations in Crouzon and Jackson–Weiss syndromes show allelic heterogeneity and phenotypic variability". <i>Human Molecular Genetics</i>. <b>4</b> (7): 1229–33. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fhmg%2F4.7.1229">10.1093/hmg/4.7.1229</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/8528214">8528214</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Human+Molecular+Genetics&rft.atitle=Novel+FGFR2+mutations+in+Crouzon+and+Jackson%E2%80%93Weiss+syndromes+show+allelic+heterogeneity+and+phenotypic+variability&rft.volume=4&rft.issue=7&rft.pages=1229-33&rft.date=1995-07&rft_id=info%3Adoi%2F10.1093%2Fhmg%2F4.7.1229&rft_id=info%3Apmid%2F8528214&rft.aulast=Park&rft.aufirst=WJ&rft.au=Meyers%2C+GA&rft.au=Li%2C+X&rft.au=Theda%2C+C&rft.au=Day%2C+D&rft.au=Orlow%2C+SJ&rft.au=Jones%2C+MC&rft.au=Jabs%2C+EW&rfr_id=info%3Asid%2Fen.wikipedia.org%3AFibroblast+growth+factor+receptor+2" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMarieDebiaisHaÿ2003" class="citation journal cs1">Marie PJ, Debiais F, Haÿ E (2003). "Regulation of human cranial osteoblast phenotype by FGF-2, FGFR-2 and BMP-2 signaling". <i>Histology and Histopathology</i>. <b>17</b> (3): 877–85. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.14670%2FHH-17.877">10.14670/HH-17.877</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12168799">12168799</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Histology+and+Histopathology&rft.atitle=Regulation+of+human+cranial+osteoblast+phenotype+by+FGF-2%2C+FGFR-2+and+BMP-2+signaling&rft.volume=17&rft.issue=3&rft.pages=877-85&rft.date=2003&rft_id=info%3Adoi%2F10.14670%2FHH-17.877&rft_id=info%3Apmid%2F12168799&rft.aulast=Marie&rft.aufirst=PJ&rft.au=Debiais%2C+F&rft.au=Ha%C3%BF%2C+E&rfr_id=info%3Asid%2Fen.wikipedia.org%3AFibroblast+growth+factor+receptor+2" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFIbrahimiChiuMcCarthyMohammadi2005" class="citation journal cs1">Ibrahimi OA, Chiu ES, McCarthy JG, Mohammadi M (Jan 2005). "Understanding the molecular basis of Apert syndrome". <i>Plastic and Reconstructive Surgery</i>. <b>115</b> (1): 264–70. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1097%2F01.PRS.0000146703.08958.95">10.1097/01.PRS.0000146703.08958.95</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15622262">15622262</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:23282194">23282194</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Plastic+and+Reconstructive+Surgery&rft.atitle=Understanding+the+molecular+basis+of+Apert+syndrome&rft.volume=115&rft.issue=1&rft.pages=264-70&rft.date=2005-01&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A23282194%23id-name%3DS2CID&rft_id=info%3Apmid%2F15622262&rft_id=info%3Adoi%2F10.1097%2F01.PRS.0000146703.08958.95&rft.aulast=Ibrahimi&rft.aufirst=OA&rft.au=Chiu%2C+ES&rft.au=McCarthy%2C+JG&rft.au=Mohammadi%2C+M&rfr_id=info%3Asid%2Fen.wikipedia.org%3AFibroblast+growth+factor+receptor+2" class="Z3988"></span></li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Fibroblast_growth_factor_receptor_2&action=edit&section=12" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=craniosynostosis">GeneReviews/NIH/NCBI/UW entry on FGFR-Related Craniosynostosis Syndromes</a></li> <li><a rel="nofollow" class="external text" href="https://meshb.nlm.nih.gov/record/ui?name=Fibroblast+Growth+Factor+Receptor+2">Fibroblast+Growth+Factor+Receptor+2</a> at the U.S. National Library of Medicine <a href="/wiki/Medical_Subject_Headings" title="Medical Subject Headings">Medical Subject Headings</a> (MeSH)</li> <li><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&singleSearch=knownCanonical&position=FGFR2"><i>FGFR2</i></a> human gene location in the <a href="/wiki/UCSC_Genome_Browser" title="UCSC Genome Browser">UCSC Genome Browser</a>.</li> <li><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_type=knownGene&hgg_gene=FGFR2"><i>FGFR2</i></a> human gene details in the <a href="/wiki/UCSC_Genome_Browser" title="UCSC Genome Browser">UCSC Genome Browser</a>.</li></ul> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output .hlist.inline ul,.mw-parser-output .hlist dl dl,.mw-parser-output .hlist dl ol,.mw-parser-output .hlist dl ul,.mw-parser-output .hlist ol dl,.mw-parser-output .hlist ol ol,.mw-parser-output .hlist ol ul,.mw-parser-output .hlist ul dl,.mw-parser-output .hlist ul ol,.mw-parser-output .hlist ul ul{display:inline}.mw-parser-output .hlist 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template">e</abbr></a></li></ul></div><div id="PDB_gallery" style="font-size:114%;margin:0 4em">PDB gallery</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><ul class="gallery mw-gallery-traditional nochecker" style="line-height:130%"> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1djs_EBI.jpg" class="mw-file-description" title="1djs: LIGAND-BINDING PORTION OF FIBROBLAST GROWTH FACTOR RECEPTOR 2 IN COMPLEX WITH FGF1"><img alt="1djs: LIGAND-BINDING PORTION OF FIBROBLAST GROWTH FACTOR RECEPTOR 2 IN COMPLEX WITH FGF1" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a8/PDB_1djs_EBI.jpg/180px-PDB_1djs_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a8/PDB_1djs_EBI.jpg/270px-PDB_1djs_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a8/PDB_1djs_EBI.jpg/360px-PDB_1djs_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1djs</b>: LIGAND-BINDING PORTION OF FIBROBLAST GROWTH FACTOR RECEPTOR 2 IN COMPLEX WITH FGF1</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1e0o_EBI.jpg" class="mw-file-description" title="1e0o: CRYSTAL STRUCTURE OF A TERNARY FGF1-FGFR2-HEPARIN COMPLEX"><img alt="1e0o: CRYSTAL STRUCTURE OF A TERNARY FGF1-FGFR2-HEPARIN COMPLEX" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a0/PDB_1e0o_EBI.jpg/180px-PDB_1e0o_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a0/PDB_1e0o_EBI.jpg/270px-PDB_1e0o_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a0/PDB_1e0o_EBI.jpg/360px-PDB_1e0o_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1e0o</b>: CRYSTAL STRUCTURE OF A TERNARY FGF1-FGFR2-HEPARIN COMPLEX</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1ev2_EBI.jpg" class="mw-file-description" title="1ev2: CRYSTAL STRUCTURE OF FGF2 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 2 (FGFR2)"><img alt="1ev2: CRYSTAL STRUCTURE OF FGF2 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 2 (FGFR2)" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a8/PDB_1ev2_EBI.jpg/180px-PDB_1ev2_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a8/PDB_1ev2_EBI.jpg/270px-PDB_1ev2_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a8/PDB_1ev2_EBI.jpg/360px-PDB_1ev2_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1ev2</b>: CRYSTAL STRUCTURE OF FGF2 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 2 (FGFR2)</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1gjo_EBI.jpg" class="mw-file-description" title="1gjo: THE FGFR2 TYROSINE KINASE DOMAIN"><img alt="1gjo: THE FGFR2 TYROSINE KINASE DOMAIN" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d7/PDB_1gjo_EBI.jpg/180px-PDB_1gjo_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d7/PDB_1gjo_EBI.jpg/270px-PDB_1gjo_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d7/PDB_1gjo_EBI.jpg/360px-PDB_1gjo_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1gjo</b>: THE FGFR2 TYROSINE KINASE DOMAIN</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1ii4_EBI.jpg" class="mw-file-description" title="1ii4: CRYSTAL STRUCTURE OF SER252TRP APERT MUTANT FGF RECEPTOR 2 (FGFR2) IN COMPLEX WITH FGF2"><img alt="1ii4: CRYSTAL STRUCTURE OF SER252TRP APERT MUTANT FGF RECEPTOR 2 (FGFR2) IN COMPLEX WITH FGF2" src="//upload.wikimedia.org/wikipedia/commons/thumb/e/e0/PDB_1ii4_EBI.jpg/180px-PDB_1ii4_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/e/e0/PDB_1ii4_EBI.jpg/270px-PDB_1ii4_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/e/e0/PDB_1ii4_EBI.jpg/360px-PDB_1ii4_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1ii4</b>: CRYSTAL STRUCTURE OF SER252TRP APERT MUTANT FGF RECEPTOR 2 (FGFR2) IN COMPLEX WITH FGF2</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1iil_EBI.jpg" class="mw-file-description" title="1iil: CRYSTAL STRUCTURE OF PRO253ARG APERT MUTANT FGF RECEPTOR 2 (FGFR2) IN COMPLEX WITH FGF2"><img alt="1iil: CRYSTAL STRUCTURE OF PRO253ARG APERT MUTANT FGF RECEPTOR 2 (FGFR2) IN COMPLEX WITH FGF2" src="//upload.wikimedia.org/wikipedia/commons/thumb/1/10/PDB_1iil_EBI.jpg/180px-PDB_1iil_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/10/PDB_1iil_EBI.jpg/270px-PDB_1iil_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/10/PDB_1iil_EBI.jpg/360px-PDB_1iil_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1iil</b>: CRYSTAL STRUCTURE OF PRO253ARG APERT MUTANT FGF RECEPTOR 2 (FGFR2) IN COMPLEX WITH FGF2</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1nun_EBI.jpg" class="mw-file-description" title="1nun: Crystal Structure Analysis of the FGF10-FGFR2b Complex"><img alt="1nun: Crystal Structure Analysis of the FGF10-FGFR2b Complex" src="//upload.wikimedia.org/wikipedia/commons/thumb/5/5a/PDB_1nun_EBI.jpg/180px-PDB_1nun_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/5a/PDB_1nun_EBI.jpg/270px-PDB_1nun_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/5a/PDB_1nun_EBI.jpg/360px-PDB_1nun_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1nun</b>: Crystal Structure Analysis of the FGF10-FGFR2b Complex</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1oec_EBI.jpg" class="mw-file-description" title="1oec: FGFR2 KINASE DOMAIN"><img alt="1oec: FGFR2 KINASE DOMAIN" src="//upload.wikimedia.org/wikipedia/commons/thumb/8/86/PDB_1oec_EBI.jpg/180px-PDB_1oec_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/86/PDB_1oec_EBI.jpg/270px-PDB_1oec_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/86/PDB_1oec_EBI.jpg/360px-PDB_1oec_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1oec</b>: FGFR2 KINASE DOMAIN</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1wvz_EBI.jpg" class="mw-file-description" title="1wvz: Solution Structure of the D2 Domain of the Fibroblast Growth Factor"><img alt="1wvz: Solution Structure of the D2 Domain of the Fibroblast Growth Factor" src="//upload.wikimedia.org/wikipedia/commons/thumb/c/cb/PDB_1wvz_EBI.jpg/180px-PDB_1wvz_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/cb/PDB_1wvz_EBI.jpg/270px-PDB_1wvz_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/cb/PDB_1wvz_EBI.jpg/360px-PDB_1wvz_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1wvz</b>: Solution Structure of the D2 Domain of the Fibroblast Growth Factor</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_2fdb_EBI.jpg" class="mw-file-description" title="2fdb: Crystal Structure of Fibroblast growth factor (FGF)8b in complex with FGF Receptor (FGFR) 2c"><img alt="2fdb: Crystal Structure of Fibroblast growth factor (FGF)8b in complex with FGF Receptor (FGFR) 2c" src="//upload.wikimedia.org/wikipedia/commons/thumb/2/2b/PDB_2fdb_EBI.jpg/180px-PDB_2fdb_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/2b/PDB_2fdb_EBI.jpg/270px-PDB_2fdb_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/2b/PDB_2fdb_EBI.jpg/360px-PDB_2fdb_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>2fdb</b>: Crystal Structure of Fibroblast growth factor (FGF)8b in complex with FGF Receptor (FGFR) 2c</div> </li> </ul></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Proteins:_clusters_of_differentiation_(see_also_list_of_human_clusters_of_differentiation)" style="padding:3px"><table class="nowraplinks mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background:#e7dcc3"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Clusters_of_differentiation" title="Template:Clusters of differentiation"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Clusters_of_differentiation" title="Template talk:Clusters of differentiation"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Clusters_of_differentiation" title="Special:EditPage/Template:Clusters of differentiation"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Proteins:_clusters_of_differentiation_(see_also_list_of_human_clusters_of_differentiation)" style="font-size:114%;margin:0 4em"><a href="/wiki/Protein" title="Protein">Proteins</a>: <a href="/wiki/Cluster_of_differentiation" title="Cluster of differentiation">clusters of differentiation</a> (see also <a href="/wiki/List_of_human_clusters_of_differentiation" title="List of human clusters of differentiation">list of human clusters of differentiation</a>)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">1–50</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CD1" title="CD1">CD1</a> <ul><li><a href="/wiki/Group_1_CD1" class="mw-redirect" title="Group 1 CD1">a-c</a></li> <li><a href="/wiki/CD1A" title="CD1A">1A</a></li> <li><a href="/wiki/CD1b" title="CD1b">1B</a></li> <li><a href="/wiki/CD1D" title="CD1D">1D</a></li> <li><a href="/wiki/CD1E" title="CD1E">1E</a></li></ul></li> <li><a href="/wiki/CD2" title="CD2">CD2</a></li> <li><a href="/wiki/CD3_(immunology)" title="CD3 (immunology)">CD3</a> <ul><li><a href="/wiki/CD3G" title="CD3G">γ</a></li> <li><a href="/wiki/CD3D" title="CD3D">δ</a></li> <li><a href="/wiki/CD3E" class="mw-redirect" title="CD3E">ε</a></li></ul></li> <li><a href="/wiki/CD4" title="CD4">CD4</a></li> <li><a href="/wiki/CD5_(protein)" title="CD5 (protein)">CD5</a></li> <li><a href="/wiki/CD6" title="CD6">CD6</a></li> <li><a href="/wiki/CD7" title="CD7">CD7</a></li> <li><a href="/wiki/CD8" title="CD8">CD8</a> <ul><li><a href="/wiki/CD8A" title="CD8A">a</a></li></ul></li> <li><a href="/wiki/CD9" title="CD9">CD9</a></li> <li><a href="/wiki/Neprilysin" title="Neprilysin">CD10</a></li> <li><i>CD11</i> <ul><li><a href="/wiki/CD11a" class="mw-redirect" title="CD11a">a</a></li> <li><a href="/wiki/Integrin_alpha_M" title="Integrin alpha M">b</a></li> <li><a href="/wiki/CD11c" class="mw-redirect" title="CD11c">c</a></li> <li><a href="/wiki/ITGAD" class="mw-redirect" title="ITGAD">d</a></li></ul></li> <li><a href="/wiki/Alanine_aminopeptidase" title="Alanine aminopeptidase">CD13</a></li> <li><a href="/wiki/CD14" title="CD14">CD14</a></li> <li><a href="/wiki/CD15" class="mw-redirect" title="CD15">CD15</a></li> <li><a href="/wiki/CD16" title="CD16">CD16</a> <ul><li><a href="/wiki/FCGR3A" title="FCGR3A">A</a></li> <li><a href="/wiki/FCGR3B" title="FCGR3B">B</a></li></ul></li> <li><a href="/wiki/CD18" class="mw-redirect" title="CD18">CD18</a></li> <li><a href="/wiki/CD19" title="CD19">CD19</a></li> <li><a href="/wiki/CD20" title="CD20">CD20</a></li> <li><a href="/wiki/Complement_receptor_2" title="Complement receptor 2">CD21</a></li> <li><a href="/wiki/CD22" title="CD22">CD22</a></li> <li><a href="/wiki/CD23" title="CD23">CD23</a></li> <li><a href="/wiki/CD24" title="CD24">CD24</a></li> <li><a href="/wiki/IL2RA" title="IL2RA">CD25</a></li> <li><a href="/wiki/Dipeptidyl_peptidase-4" title="Dipeptidyl peptidase-4">CD26</a></li> <li><a href="/wiki/CD27" title="CD27">CD27</a></li> <li><a href="/wiki/CD28" title="CD28">CD28</a></li> <li><a href="/wiki/Integrin_beta_1" title="Integrin beta 1">CD29</a></li> <li><a href="/wiki/CD30" title="CD30">CD30</a></li> <li><a href="/wiki/CD31" title="CD31">CD31</a></li> <li><a href="/wiki/CD32" title="CD32">CD32</a> <ul><li><a href="/wiki/FCGR2A" title="FCGR2A">A</a></li> <li><a href="/wiki/FCGR2B" title="FCGR2B">B</a></li></ul></li> <li><a href="/wiki/CD33" title="CD33">CD33</a></li> <li><a href="/wiki/CD34" title="CD34">CD34</a></li> <li><a href="/wiki/Complement_receptor_1" title="Complement receptor 1">CD35</a></li> <li><a href="/wiki/CD36" title="CD36">CD36</a></li> <li><a href="/wiki/CD37" title="CD37">CD37</a></li> <li><a href="/wiki/CD38" title="CD38">CD38</a></li> <li><a href="/wiki/ENTPD1" title="ENTPD1">CD39</a></li> <li><a href="/wiki/CD40_(protein)" title="CD40 (protein)">CD40</a></li> <li><a href="/wiki/ITGA2B" class="mw-redirect" title="ITGA2B">CD41</a></li> <li><a href="/wiki/Glycoprotein_Ib" title="Glycoprotein Ib">CD42</a> <ul><li><a href="/wiki/Glycoprotein_IX" title="Glycoprotein IX">a</a></li> <li><a href="/wiki/GP1BA" title="GP1BA">b</a></li> <li><a href="/wiki/GP1BB" title="GP1BB">c</a></li> <li><a href="/wiki/GP5_(gene)" title="GP5 (gene)">d</a></li></ul></li> <li><a href="/wiki/CD43" title="CD43">CD43</a></li> <li><a href="/wiki/CD44" title="CD44">CD44</a></li> <li><a href="/wiki/PTPRC" title="PTPRC">CD45</a></li> <li><a href="/wiki/CD46" title="CD46">CD46</a></li> <li><a href="/wiki/CD47" title="CD47">CD47</a></li> <li><a href="/wiki/CD48" title="CD48">CD48</a></li> <li><i>CD49</i> <ul><li><a href="/wiki/CD49a" class="mw-redirect" title="CD49a">a</a></li> <li><a href="/wiki/CD49b" class="mw-redirect" title="CD49b">b</a></li> <li><a href="/wiki/CD49c" class="mw-redirect" title="CD49c">c</a></li> <li><a href="/wiki/CD49d" class="mw-redirect" title="CD49d">d</a></li> <li><a href="/wiki/ITGA5" class="mw-redirect" title="ITGA5">e</a></li> <li><a href="/wiki/ITGA6" class="mw-redirect" title="ITGA6">f</a></li></ul></li> <li><a href="/wiki/ICAM3" title="ICAM3">CD50</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">51–100</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/ITGAV" class="mw-redirect" title="ITGAV">CD51</a></li> <li><a href="/wiki/CD52" title="CD52">CD52</a></li> <li><a href="/wiki/CD53" title="CD53">CD53</a></li> <li><a href="/wiki/ICAM-1" title="ICAM-1">CD54</a></li> <li><a href="/wiki/Decay-accelerating_factor" title="Decay-accelerating factor">CD55</a></li> <li><a href="/wiki/Neural_cell_adhesion_molecule" title="Neural cell adhesion molecule">CD56</a></li> <li><a href="/wiki/B3GAT1" title="B3GAT1">CD57</a></li> <li><a href="/wiki/CD58" title="CD58">CD58</a></li> <li><a href="/wiki/CD59" title="CD59">CD59</a></li> <li><a href="/wiki/CD61" class="mw-redirect" title="CD61">CD61</a></li> <li><a href="/wiki/Selectin" title="Selectin">CD62</a> <ul><li><a href="/wiki/E-selectin" title="E-selectin">E</a></li> <li><a href="/wiki/L-selectin" title="L-selectin">L</a></li> <li><a href="/wiki/P-selectin" title="P-selectin">P</a></li></ul></li> <li><a href="/wiki/CD63" title="CD63">CD63</a></li> <li><a href="/wiki/CD64_(biology)" title="CD64 (biology)">CD64</a> <ul><li><a href="/wiki/FCGR1A" title="FCGR1A">A</a></li> <li><a href="/wiki/FCGR1B" class="mw-redirect" title="FCGR1B">B</a></li> <li><a href="/wiki/FCGR1C" class="mw-redirect" title="FCGR1C">C</a></li></ul></li> <li><a href="/wiki/Carcinoembryonic_antigen" title="Carcinoembryonic antigen">CD66</a> <ul><li><a href="/wiki/CEACAM1" title="CEACAM1">a</a></li> <li><a href="/wiki/CEACAM8" title="CEACAM8">b</a></li> <li><a href="/wiki/CEACAM6" title="CEACAM6">c</a></li> <li><a href="/wiki/CEACAM3" title="CEACAM3">d</a></li> <li><a href="/wiki/CEACAM5" title="CEACAM5">e</a></li> <li><a href="/wiki/PSG1_(gene)" class="mw-redirect" title="PSG1 (gene)">f</a></li></ul></li> <li><a href="/wiki/CD68" title="CD68">CD68</a></li> <li><a href="/wiki/CD69" title="CD69">CD69</a></li> <li><a href="/wiki/CD70" title="CD70">CD70</a></li> <li><a href="/wiki/TFRC" class="mw-redirect" title="TFRC">CD71</a></li> <li><a href="/wiki/CD72" title="CD72">CD72</a></li> <li><a href="/wiki/NT5E" title="NT5E">CD73</a></li> <li><a href="/wiki/CD74" title="CD74">CD74</a></li> <li><a href="/wiki/CD78" title="CD78">CD78</a></li> <li><a href="/wiki/CD79" title="CD79">CD79</a> <ul><li><a href="/wiki/CD79A" title="CD79A">a</a></li> <li><a href="/wiki/CD79B" title="CD79B">b</a></li></ul></li> <li><a href="/wiki/CD80" title="CD80">CD80</a></li> <li><a href="/wiki/CD81" title="CD81">CD81</a></li> <li><a href="/wiki/CD82_(gene)" title="CD82 (gene)">CD82</a></li> <li><a href="/wiki/CD83" title="CD83">CD83</a></li> <li><a href="/wiki/CD84" title="CD84">CD84</a></li> <li><i>CD85</i> <ul><li><a href="/wiki/LILRB3" title="LILRB3">a</a></li> <li><a href="/wiki/LILRB2" title="LILRB2">d</a></li> <li><a href="/wiki/LILRA3" title="LILRA3">e</a></li> <li><a href="/wiki/LILRA2" title="LILRA2">h</a></li> <li><a href="/wiki/LILRB1" title="LILRB1">j</a></li> <li><a href="/wiki/LILRB4" title="LILRB4">k</a></li></ul></li> <li><a href="/wiki/CD86" title="CD86">CD86</a></li> <li><a href="/wiki/Urokinase_receptor" title="Urokinase receptor">CD87</a></li> <li><a href="/wiki/C5a_receptor" title="C5a receptor">CD88</a></li> <li><a href="/wiki/FCAR" title="FCAR">CD89</a></li> <li><a href="/wiki/CD90" title="CD90">CD90</a></li> <li><a href="/wiki/LRP1" title="LRP1">CD91</a> - <a href="/wiki/SLC44A1" class="mw-redirect" title="SLC44A1">CD92</a></li> <li><a href="/wiki/CD93" title="CD93">CD93</a></li> <li><a href="/wiki/KLRD1" title="KLRD1">CD94</a></li> <li><a href="/wiki/Fas_receptor" title="Fas receptor">CD95</a></li> <li><a href="/wiki/CD96" title="CD96">CD96</a></li> <li><a href="/wiki/CD97" title="CD97">CD97</a></li> <li><a href="/wiki/CD98" title="CD98">CD98</a></li> <li><a href="/wiki/CD99" title="CD99">CD99</a></li> <li><a href="/wiki/SEMA4D" title="SEMA4D">CD100</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">101–150</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/IGSF2" title="IGSF2">CD101</a></li> <li><a href="/wiki/ICAM2" title="ICAM2">CD102</a></li> <li><a href="/wiki/ITGAE" title="ITGAE">CD103</a></li> <li><a href="/wiki/ITGB4" class="mw-redirect" title="ITGB4">CD104</a></li> <li><a href="/wiki/Endoglin" title="Endoglin">CD105</a></li> <li><a href="/wiki/VCAM-1" title="VCAM-1">CD106</a></li> <li><i>CD107</i> <ul><li><a href="/wiki/LAMP1" title="LAMP1">a</a></li> <li><a href="/wiki/LAMP2" title="LAMP2">b</a></li></ul></li> <li><a href="/wiki/SEMA7A" title="SEMA7A">CD108</a></li> <li><a href="/wiki/CD109" title="CD109">CD109</a></li> <li><a href="/wiki/Myeloproliferative_leukemia_virus_oncogene" class="mw-redirect" title="Myeloproliferative leukemia virus oncogene">CD110</a></li> <li><a href="/wiki/PVRL1" class="mw-redirect" title="PVRL1">CD111</a></li> <li><a href="/wiki/PVRL2" class="mw-redirect" title="PVRL2">CD112</a></li> <li><a href="/wiki/PVRL3" class="mw-redirect" title="PVRL3">CD113</a></li> <li><a href="/wiki/Granulocyte_colony-stimulating_factor_receptor" title="Granulocyte colony-stimulating factor receptor">CD114</a></li> <li><a href="/wiki/Colony_stimulating_factor_1_receptor" title="Colony stimulating factor 1 receptor">CD115</a></li> <li><a href="/wiki/Granulocyte_macrophage_colony-stimulating_factor_receptor" class="mw-redirect" title="Granulocyte macrophage colony-stimulating factor receptor">CD116</a></li> <li><a href="/wiki/KIT_(gene)" title="KIT (gene)">CD117</a></li> <li><a href="/wiki/Leukemia_inhibitory_factor_receptor" title="Leukemia inhibitory factor receptor">CD118</a></li> <li><a href="/wiki/Interferon_gamma_receptor_1" title="Interferon gamma receptor 1">CD119</a></li> <li><a href="/wiki/CD120" title="CD120">CD120</a> <ul><li><a href="/wiki/TNFRSF1A" class="mw-redirect" title="TNFRSF1A">a</a></li> <li><a href="/wiki/TNFRSF1B" class="mw-redirect" title="TNFRSF1B">b</a></li></ul></li> <li><i>CD121</i> <ul><li><a href="/wiki/Interleukin_1_receptor,_type_I" title="Interleukin 1 receptor, type I">a</a></li> <li><a href="/wiki/Interleukin_1_receptor,_type_II" title="Interleukin 1 receptor, type II">b</a></li></ul></li> <li><a href="/wiki/IL2RB" title="IL2RB">CD122</a></li> <li><a href="/wiki/IL3RA" title="IL3RA">CD123</a></li> <li><a href="/wiki/Interleukin-4_receptor" title="Interleukin-4 receptor">CD124</a></li> <li><a href="/wiki/Interleukin_5_receptor_alpha_subunit" title="Interleukin 5 receptor alpha subunit">CD125</a></li> <li><a href="/wiki/Interleukin-6_receptor" title="Interleukin-6 receptor">CD126</a></li> <li><a href="/wiki/Interleukin-7_receptor" title="Interleukin-7 receptor">CD127</a></li> <li><a href="/wiki/Interleukin-9_receptor" title="Interleukin-9 receptor">CD129</a></li> <li><a href="/wiki/Glycoprotein_130" title="Glycoprotein 130">CD130</a></li> <li><a href="/wiki/CSF2RB" title="CSF2RB">CD131</a></li> <li><a href="/wiki/Common_gamma_chain" title="Common gamma chain">CD132</a></li> <li><a href="/wiki/CD133" title="CD133">CD133</a></li> <li><a href="/wiki/CD134" title="CD134">CD134</a></li> <li><a href="/wiki/CD135" title="CD135">CD135</a></li> <li><a href="/wiki/MST1R" title="MST1R">CD136</a></li> <li><a href="/wiki/CD137" title="CD137">CD137</a></li> <li><a href="/wiki/Syndecan_1" title="Syndecan 1">CD138</a></li> <li><a href="/wiki/PDGFRB" title="PDGFRB">CD140b</a></li> <li><a href="/wiki/Thrombomodulin" title="Thrombomodulin">CD141</a></li> <li><a href="/wiki/Tissue_factor" title="Tissue factor">CD142</a></li> <li><a href="/wiki/Angiotensin-converting_enzyme" title="Angiotensin-converting enzyme">CD143</a></li> <li><a href="/wiki/VE-cadherin" title="VE-cadherin">CD144</a></li> <li><a href="/wiki/CD146" title="CD146">CD146</a></li> <li><a href="/wiki/Basigin" title="Basigin">CD147</a></li> <li><a href="/wiki/PTPRJ" title="PTPRJ">CD148</a></li> <li><a href="/wiki/SLAMF1" title="SLAMF1">CD150</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">151–200</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CD151" title="CD151">CD151</a></li> <li><a href="/wiki/CTLA-4" class="mw-redirect" title="CTLA-4">CD152</a></li> <li><a href="/wiki/CD153" title="CD153">CD153</a></li> <li><a href="/wiki/CD154" title="CD154">CD154</a></li> <li><a href="/wiki/CD155" title="CD155">CD155</a></li> <li><i>CD156</i> <ul><li><a href="/wiki/ADAM8" title="ADAM8">a</a></li> <li><a href="/wiki/ADAM17" title="ADAM17">b</a></li> <li><a href="/wiki/ADAM10" title="ADAM10">c</a></li></ul></li> <li><a href="/wiki/BST1" title="BST1">CD157</a></li> <li><i>CD158</i> (<a href="/wiki/KIR2DL1" title="KIR2DL1">a</a></li> <li><a href="/wiki/KIR2DL4" title="KIR2DL4">d</a></li> <li><a href="/wiki/KIR3DL1" title="KIR3DL1">e</a></li> <li><a href="/wiki/KIR2DS4" title="KIR2DS4">i</a></li> <li><a href="/wiki/KIR3DL2" title="KIR3DL2">k</a>)</li> <li><i>CD159</i> <ul><li><a href="/wiki/NKG2" title="NKG2">a</a></li> <li><a href="/wiki/KLRC2" title="KLRC2">c</a></li></ul></li> <li><a href="/wiki/CD160" title="CD160">CD160</a></li> <li><a href="/wiki/KLRB1" title="KLRB1">CD161</a></li> <li><a href="/wiki/P-selectin_glycoprotein_ligand-1" title="P-selectin glycoprotein ligand-1">CD162</a></li> <li><a href="/wiki/CD163" title="CD163">CD163</a></li> <li><a href="/wiki/CD164" title="CD164">CD164</a></li> <li><a href="/wiki/ALCAM" title="ALCAM">CD166</a></li> <li><i>CD167</i> <ul><li><a href="/wiki/DDR1" title="DDR1">a</a></li> <li><a href="/wiki/Discoidin_domain-containing_receptor_2" title="Discoidin domain-containing receptor 2">b</a></li></ul></li> <li><a href="/wiki/Hyaluronan-mediated_motility_receptor" title="Hyaluronan-mediated motility receptor">CD168</a></li> <li><a href="/wiki/Sialoadhesin" title="Sialoadhesin">CD169</a></li> <li><a href="/wiki/SIGLEC5" title="SIGLEC5">CD170</a></li> <li><a href="/wiki/L1_(protein)" title="L1 (protein)">CD171</a></li> <li><i>CD172</i> <ul><li><a href="/wiki/Signal-regulatory_protein_alpha" title="Signal-regulatory protein alpha">a</a></li> <li><a href="/wiki/SIRPB1" title="SIRPB1">b</a></li> <li><a href="/wiki/SIRPG" title="SIRPG">g</a></li></ul></li> <li><a href="/wiki/Fucosyltransferase_3" title="Fucosyltransferase 3">CD174</a></li> <li><a href="/wiki/CD177" title="CD177">CD177</a></li> <li><a href="/wiki/Fas_ligand" title="Fas ligand">CD178</a></li> <li><i>CD179</i> <ul><li><a href="/wiki/VPREB1" title="VPREB1">a</a></li> <li><a href="/wiki/IGLL1" title="IGLL1">b</a></li></ul></li> <li><a href="/wiki/CD180" title="CD180">CD180</a></li> <li><a href="/wiki/Interleukin_8_receptor,_alpha" title="Interleukin 8 receptor, alpha">CD181</a></li> <li><a href="/wiki/Interleukin_8_receptor,_beta" title="Interleukin 8 receptor, beta">CD182</a></li> <li><a href="/wiki/CXCR3" title="CXCR3">CD183</a></li> <li><a href="/wiki/CXCR4" title="CXCR4">CD184</a></li> <li><a href="/wiki/CXCR5" title="CXCR5">CD185</a></li> <li><a href="/wiki/CXCR6" title="CXCR6">CD186</a></li> <li><a href="/wiki/CCR1" title="CCR1">CD191</a></li> <li><a href="/wiki/CCR2" title="CCR2">CD192</a></li> <li><a href="/wiki/CCR3_(gene)" title="CCR3 (gene)">CD193</a></li> <li><a href="/wiki/CCR4" title="CCR4">CD194</a></li> <li><a href="/wiki/CCR5" title="CCR5">CD195</a></li> <li><a href="/wiki/C-C_chemokine_receptor_type_6" title="C-C chemokine receptor type 6">CD196</a></li> <li><a href="/wiki/C-C_chemokine_receptor_type_7" title="C-C chemokine receptor type 7">CD197</a></li> <li><a href="/wiki/CCR8_(gene)" title="CCR8 (gene)">CDw198</a></li> <li><a href="/wiki/CCR9" title="CCR9">CDw199</a></li> <li><a href="/wiki/CD200" title="CD200">CD200</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">201–250</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Endothelial_protein_C_receptor" title="Endothelial protein C receptor">CD201</a></li> <li><a href="/wiki/TEK_tyrosine_kinase" title="TEK tyrosine kinase">CD202b</a></li> <li><a href="/wiki/MSR1" title="MSR1">CD204</a></li> <li><a href="/wiki/LY75" class="mw-redirect" title="LY75">CD205</a></li> <li><a href="/wiki/Mannose_receptor" title="Mannose receptor">CD206</a></li> <li><a href="/wiki/CD207" class="mw-redirect" title="CD207">CD207</a></li> <li><a href="/wiki/LAMP3" title="LAMP3">CD208</a></li> <li><a href="/wiki/DC-SIGN" title="DC-SIGN">CD209</a></li> <li><i>CDw210</i> <ul><li><a href="/wiki/Interleukin_10_receptor,_alpha_subunit" title="Interleukin 10 receptor, alpha subunit">a</a></li> <li><a href="/wiki/Interleukin_10_receptor,_beta_subunit" title="Interleukin 10 receptor, beta subunit">b</a></li></ul></li> <li><a href="/wiki/Interleukin_12_receptor,_beta_1_subunit" title="Interleukin 12 receptor, beta 1 subunit">CD212</a></li> <li><i>CD213a</i> <ul><li><a href="/wiki/IL13RA1" class="mw-redirect" title="IL13RA1">1</a></li> <li><a href="/wiki/IL13RA2" title="IL13RA2">2</a></li></ul></li> <li><a href="/wiki/IL17RA" title="IL17RA">CD217</a></li> <li><i>CD218</i> (<a href="/wiki/IL18R1" title="IL18R1">a</a></li> <li><a href="/wiki/IL18RAP" title="IL18RAP">b</a>)</li> <li><a href="/wiki/Insulin_receptor" title="Insulin receptor">CD220</a></li> <li><a href="/wiki/Insulin-like_growth_factor_1_receptor" title="Insulin-like growth factor 1 receptor">CD221</a></li> <li><a href="/wiki/Insulin-like_growth_factor_2_receptor" title="Insulin-like growth factor 2 receptor">CD222</a></li> <li><a href="/wiki/LAG3" class="mw-redirect" title="LAG3">CD223</a></li> <li><a href="/wiki/GGT1" class="mw-redirect" title="GGT1">CD224</a></li> <li><a href="/wiki/IFITM1" title="IFITM1">CD225</a></li> <li><a href="/wiki/CD226" title="CD226">CD226</a></li> <li><a href="/wiki/MUC1" class="mw-redirect" title="MUC1">CD227</a></li> <li><a href="/wiki/MFI2" class="mw-redirect" title="MFI2">CD228</a></li> <li><a href="/wiki/LY9" title="LY9">CD229</a></li> <li><a href="/wiki/PRNP" class="mw-redirect" title="PRNP">CD230</a></li> <li><a href="/wiki/Band_3" class="mw-redirect" title="Band 3">CD233</a></li> <li><a href="/wiki/Duffy_antigen_system" title="Duffy antigen system">CD234</a></li> <li><i>CD235</i> <ul><li><a href="/wiki/GYPA" class="mw-redirect" title="GYPA">a</a></li> <li><a href="/wiki/GYPB" title="GYPB">b</a></li></ul></li> <li><a href="/wiki/Glycophorin_C" title="Glycophorin C">CD236</a></li> <li><a href="/wiki/Kell_antigen_system" title="Kell antigen system">CD238</a></li> <li><a href="/wiki/Basal_cell_adhesion_molecule" title="Basal cell adhesion molecule">CD239</a></li> <li><a href="/wiki/RHCE_(gene)" title="RHCE (gene)">CD240CE</a></li> <li><a href="/wiki/RHD_(gene)" title="RHD (gene)">CD240D</a></li> <li><a href="/wiki/RHAG" title="RHAG">CD241</a></li> <li><a href="/wiki/P-glycoprotein" title="P-glycoprotein">CD243</a></li> <li><a href="/wiki/CD244" title="CD244">CD244</a></li> <li><a href="/wiki/Anaplastic_lymphoma_kinase" title="Anaplastic lymphoma kinase">CD246</a></li> <li><a href="/wiki/CD247" class="mw-redirect" title="CD247">CD247</a> - <a href="/wiki/CD248" title="CD248">CD248</a></li> <li><a href="/wiki/Glutamyl_aminopeptidase" title="Glutamyl aminopeptidase">CD249</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">251–300</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/OX40L" class="mw-redirect" title="OX40L"> CD252</a></li> <li><a href="/wiki/TRAIL" title="TRAIL">CD253</a></li> <li><a href="/wiki/RANKL" title="RANKL">CD254</a></li> <li><a href="/wiki/TNFSF13" class="mw-redirect" title="TNFSF13">CD256</a></li> <li><a href="/wiki/B-cell_activating_factor" title="B-cell activating factor">CD257</a></li> <li><a href="/wiki/TNFSF14" class="mw-redirect" title="TNFSF14">CD258</a></li> <li><a href="/wiki/TNFRSF10A" class="mw-redirect" title="TNFRSF10A">CD261</a></li> <li><a href="/wiki/TNFRSF10B" class="mw-redirect" title="TNFRSF10B">CD262</a></li> <li><a href="/wiki/TNFRSF10C" class="mw-redirect" title="TNFRSF10C">CD263</a></li> <li><a href="/wiki/TNFRSF10D" class="mw-redirect" title="TNFRSF10D">CD264</a></li> <li><a href="/wiki/RANK" title="RANK">CD265</a></li> <li><a href="/wiki/TNFRSF12A" title="TNFRSF12A">CD266</a></li> <li><a href="/wiki/TNFRSF13B" class="mw-redirect" title="TNFRSF13B">CD267</a></li> <li><a href="/wiki/TNFRSF13C" class="mw-redirect" title="TNFRSF13C">CD268</a></li> <li><a href="/wiki/TNFRSF17" class="mw-redirect" title="TNFRSF17">CD269</a></li> <li><a href="/wiki/Low-affinity_nerve_growth_factor_receptor" title="Low-affinity nerve growth factor receptor">CD271</a></li> <li><a href="/wiki/BTLA" title="BTLA">CD272</a></li> <li><a href="/wiki/PDCD1LG2" title="PDCD1LG2">CD273</a></li> <li><a href="/wiki/CD274" class="mw-redirect" title="CD274">CD274</a></li> <li><a href="/wiki/ICOSLG" title="ICOSLG">CD275</a></li> <li><a href="/wiki/CD276" title="CD276">CD276</a></li> <li><a href="/wiki/CD278" title="CD278">CD278</a></li> <li><a href="/wiki/Programmed_cell_death_protein_1" title="Programmed cell death protein 1">CD279</a></li> <li><a href="/wiki/Mannose_receptor" title="Mannose receptor">CD280</a></li> <li><a href="/wiki/TLR_1" class="mw-redirect" title="TLR 1">CD281</a></li> <li><a href="/wiki/TLR2" class="mw-redirect" title="TLR2">CD282</a></li> <li><a href="/wiki/TLR3" class="mw-redirect" title="TLR3">CD283</a></li> <li><a href="/wiki/TLR4" class="mw-redirect" title="TLR4">CD284</a></li> <li><a href="/wiki/TLR6" class="mw-redirect" title="TLR6">CD286</a></li> <li><a href="/wiki/TLR8" class="mw-redirect" title="TLR8">CD288</a></li> <li><a href="/wiki/TLR9" class="mw-redirect" title="TLR9">CD289</a></li> <li><a href="/wiki/TLR10" class="mw-redirect" title="TLR10">CD290</a></li> <li><a href="/wiki/BMPR1A" title="BMPR1A">CD292</a></li> <li><a href="/wiki/BMPR1B" title="BMPR1B">CDw293</a></li> <li><a href="/wiki/CD294" class="mw-redirect" title="CD294">CD294</a></li> <li><a href="/wiki/Leptin_receptor" title="Leptin receptor">CD295</a></li> <li><a href="/wiki/ART4" title="ART4">CD297</a></li> <li><a href="/wiki/ATP1B3" title="ATP1B3">CD298</a></li> <li><a href="/wiki/CLEC4M" title="CLEC4M">CD299</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">301–350</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CD300A" title="CD300A">CD300A</a></li> <li><a href="/wiki/CLEC10A" title="CLEC10A">CD301</a></li> <li><a href="/wiki/CD302" title="CD302">CD302</a></li> <li><a href="/wiki/CLEC4C" title="CLEC4C">CD303</a></li> <li><a href="/wiki/Neuropilin" title="Neuropilin">CD304</a></li> <li><a href="/wiki/LAIR1" title="LAIR1">CD305</a></li> <li><a href="/wiki/LAIR2" title="LAIR2">CD306</a></li> <li><a href="/wiki/FCRL5" title="FCRL5">CD307</a></li> <li><a href="/wiki/Kinase_insert_domain_receptor" title="Kinase insert domain receptor">CD309</a></li> <li><a href="/wiki/EMR2" title="EMR2">CD312</a></li> <li><a href="/wiki/NKG2D" title="NKG2D">CD314</a></li> <li><a href="/wiki/PTGFRN" title="PTGFRN">CD315</a></li> <li><a href="/wiki/IGSF8" title="IGSF8">CD316</a></li> <li><a href="/wiki/Tetherin" title="Tetherin">CD317</a></li> <li><a href="/wiki/CDCP1" title="CDCP1">CD318</a></li> <li><a href="/wiki/CD320" title="CD320">CD320</a></li> <li><a href="/wiki/F11_receptor" title="F11 receptor">CD321</a></li> <li><a href="/wiki/JAM2" title="JAM2">CD322</a></li> <li><a href="/wiki/CDH1_(gene)" class="mw-redirect" title="CDH1 (gene)">CD324</a></li> <li><a href="/wiki/CDH2" class="mw-redirect" title="CDH2">CD325</a></li> <li><a href="/wiki/Epithelial_cell_adhesion_molecule" title="Epithelial cell adhesion molecule">CD326</a></li> <li><a href="/wiki/SIGLEC6" title="SIGLEC6">CD327</a></li> <li><a href="/wiki/SIGLEC7" title="SIGLEC7">CD328</a></li> <li><a href="/wiki/SIGLEC9" title="SIGLEC9">CD329</a></li> <li><a href="/wiki/Fibroblast_growth_factor_receptor_1" title="Fibroblast growth factor receptor 1">CD331</a></li> <li><a class="mw-selflink selflink">CD332</a></li> <li><a href="/wiki/Fibroblast_growth_factor_receptor_3" title="Fibroblast growth factor receptor 3">CD333</a></li> <li><a href="/wiki/Fibroblast_growth_factor_receptor_4" title="Fibroblast growth factor receptor 4">CD334</a></li> <li><a href="/wiki/NCR1" title="NCR1">CD335</a></li> <li><a href="/wiki/NCR2" title="NCR2">CD336</a></li> <li><a href="/wiki/NCR3" title="NCR3">CD337</a></li> <li><a href="/wiki/ABCG2" title="ABCG2">CD338</a></li> <li><a href="/wiki/JAG1" title="JAG1">CD339</a></li> <li><a href="/wiki/HER2/neu" class="mw-redirect" title="HER2/neu">CD340</a></li> <li><a href="/wiki/FZD4" class="mw-redirect" title="FZD4">CD344</a></li> <li><a href="/wiki/FZD9" class="mw-redirect" title="FZD9">CD349</a></li> <li><a href="/wiki/FZD10" class="mw-redirect" title="FZD10">CD350</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Protein_kinases:_tyrosine_kinases_(EC_2.7.10)" style="padding:3px"><table class="nowraplinks hlist mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Tyrosine_kinases" title="Template:Tyrosine kinases"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Tyrosine_kinases" title="Template talk:Tyrosine kinases"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Tyrosine_kinases" title="Special:EditPage/Template:Tyrosine kinases"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Protein_kinases:_tyrosine_kinases_(EC_2.7.10)" style="font-size:114%;margin:0 4em"><a href="/wiki/Protein_kinase" title="Protein kinase">Protein kinases</a>: <a href="/wiki/Tyrosine_kinase" title="Tyrosine kinase">tyrosine kinases</a> (<a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC</a> 2.7.10)</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Receptor_tyrosine_kinases_(EC_2.7.10.1)" style="font-size:114%;margin:0 4em"><a href="/wiki/Receptor_tyrosine_kinase" title="Receptor tyrosine kinase">Receptor tyrosine kinases</a> (EC 2.7.10.1)</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Growth_factor_receptor" title="Growth factor receptor">Growth factor receptors</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/ErbB" title="ErbB">EGF receptor family</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Epidermal_growth_factor_receptor" title="Epidermal growth factor receptor">EGFR</a></li> <li><a href="/wiki/HER2/neu" class="mw-redirect" title="HER2/neu">ERBB2</a></li> <li><a href="/wiki/ERBB3" title="ERBB3">ERBB3</a></li> <li><a href="/wiki/ERBB4" title="ERBB4">ERBB4</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Insulin_receptor" title="Insulin receptor">Insulin receptor</a> family</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Insulin-like_growth_factor_1_receptor" title="Insulin-like growth factor 1 receptor">IGF1R</a></li> <li><a href="/wiki/Insulin_receptor" title="Insulin receptor">INSR</a></li> <li><a href="/wiki/INSRR" title="INSRR">INSRR</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/RTK_class_III" title="RTK class III">PDGF receptor family</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Colony_stimulating_factor_1_receptor" title="Colony stimulating factor 1 receptor">CSF1R</a></li> <li><a href="/wiki/CD135" title="CD135">FLT3</a></li> <li><a href="/wiki/CD117" class="mw-redirect" title="CD117">KIT</a></li> <li><a href="/wiki/Platelet-derived_growth_factor_receptor" title="Platelet-derived growth factor receptor">PDGFR</a> (<a href="/wiki/PDGFRA" class="mw-redirect" title="PDGFRA">PDGFRA</a></li> <li><a href="/wiki/PDGFRB" title="PDGFRB">PDGFRB</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Fibroblast_growth_factor_receptor" title="Fibroblast growth factor receptor">FGF receptor</a> family</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Fibroblast_growth_factor_receptor_1" title="Fibroblast growth factor receptor 1">FGFR1</a></li> <li><a class="mw-selflink selflink">FGFR2</a></li> <li><a href="/wiki/Fibroblast_growth_factor_receptor_3" title="Fibroblast growth factor receptor 3">FGFR3</a></li> <li><a href="/wiki/Fibroblast_growth_factor_receptor_4" title="Fibroblast growth factor receptor 4">FGFR4</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/VEGF_receptors" class="mw-redirect" title="VEGF receptors">VEGF receptors</a> family</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/FLT1" class="mw-redirect" title="FLT1">VEGFR1</a></li> <li><a href="/wiki/Kinase_insert_domain_receptor" title="Kinase insert domain receptor">VEGFR2</a></li> <li><a href="/wiki/VEGFR3" class="mw-redirect" title="VEGFR3">VEGFR3</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/C-Met" class="mw-redirect" title="C-Met">HGF receptor</a> family</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/C-Met" class="mw-redirect" title="C-Met">MET</a></li> <li><a href="/wiki/MST1R" title="MST1R">RON</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Trk_receptor" title="Trk receptor">Trk receptor</a> family</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/TrkA_receptor" class="mw-redirect" title="TrkA receptor">NTRK1</a></li> <li><a href="/wiki/NTRK2" class="mw-redirect" title="NTRK2">NTRK2</a></li> <li><a href="/wiki/NTRK3" class="mw-redirect" title="NTRK3">NTRK3</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Ephrin_receptor" title="Ephrin receptor">EPH receptor</a> family</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/EPH_receptor_A1" title="EPH receptor A1">EPHA1</a></li> <li><a href="/wiki/EPH_receptor_A2" title="EPH receptor A2">EPHA2</a></li> <li><a href="/wiki/EPH_receptor_A3" title="EPH receptor A3">EPHA3</a></li> <li><a href="/wiki/EPH_receptor_A4" title="EPH receptor A4">EPHA4</a></li> <li><a href="/wiki/EPH_receptor_A5" title="EPH receptor A5">EPHA5</a></li> <li><a href="/wiki/EPHA6" title="EPHA6">EPHA6</a></li> <li><a href="/wiki/EPHA7" title="EPHA7">EPHA7</a></li> <li><a href="/wiki/EPHA8" title="EPHA8">EPHA8</a></li> <li><a href="/wiki/EPH_receptor_B1" title="EPH receptor B1">EPHB1</a></li> <li><a href="/wiki/EPH_receptor_B2" title="EPH receptor B2">EPHB2</a></li> <li><a href="/wiki/EPHB3" title="EPHB3">EPHB3</a></li> <li><a href="/wiki/EPH_receptor_B4" title="EPH receptor B4">EPHB4</a></li> <li><a href="/w/index.php?title=EPHB5&action=edit&redlink=1" class="new" title="EPHB5 (page does not exist)">EPHB5</a></li> <li><a href="/wiki/EPHB6" title="EPHB6">EPHB6</a></li> <li><a href="/w/index.php?title=EPHX&action=edit&redlink=1" class="new" title="EPHX (page does not exist)">EPHX</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Leukocyte_receptor_tyrosine_kinase" title="Leukocyte receptor tyrosine kinase">LTK receptor</a> family</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Leukocyte_receptor_tyrosine_kinase" title="Leukocyte receptor tyrosine kinase">LTK</a></li> <li><a href="/wiki/Anaplastic_lymphoma_kinase" title="Anaplastic lymphoma kinase">ALK</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Angiopoietin_receptor" title="Angiopoietin receptor">TIE receptor</a> family</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/TIE1" title="TIE1">TIE</a></li> <li><a href="/wiki/TEK_tyrosine_kinase" title="TEK tyrosine kinase">TEK</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Receptor_tyrosine_kinase-like_orphan_receptor" title="Receptor tyrosine kinase-like orphan receptor">ROR receptor</a> family</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/ROR1" title="ROR1">ROR1</a></li> <li><a href="/wiki/ROR2" title="ROR2">ROR2</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/DDR1" title="DDR1">DDR receptor</a> family</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/DDR1" title="DDR1">DDR1</a></li> <li><a href="/wiki/Discoidin_domain-containing_receptor_2" title="Discoidin domain-containing receptor 2">DDR2</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/PTK7" title="PTK7">PTK7 receptor</a> family</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/PTK7" title="PTK7">PTK7</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Related_to_receptor_tyrosine_kinase" title="Related to receptor tyrosine kinase">RYK receptor</a> family</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Related_to_receptor_tyrosine_kinase" title="Related to receptor tyrosine kinase">RYK</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/MuSK_protein" title="MuSK protein">MuSK receptor</a> family</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/MuSK_protein" title="MuSK protein">MUSK</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">ROS receptor family</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/ROS1" title="ROS1">ROS1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/AATK" title="AATK">AATYK receptor</a> family</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/AATK" title="AATK">AATYK</a></li> <li><a href="/wiki/LMTK2" title="LMTK2">AATYK2</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/AXL_receptor_tyrosine_kinase" title="AXL receptor tyrosine kinase">AXL receptor</a> family</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/AXL_receptor_tyrosine_kinase" title="AXL receptor tyrosine kinase">AXL</a></li> <li><a href="/wiki/MERTK" title="MERTK">MER</a></li> <li><a href="/wiki/TYRO3" title="TYRO3">TYRO3</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/RET_proto-oncogene" title="RET proto-oncogene">RET receptor</a> family</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/RET_proto-oncogene" title="RET proto-oncogene">RET</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">uncategorised</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/STYK1" title="STYK1">STYK1</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Non-receptor_tyrosine_kinases_(EC_2.7.10.2)" style="font-size:114%;margin:0 4em"><a href="/wiki/Non-receptor_tyrosine_kinase" title="Non-receptor tyrosine kinase">Non-receptor tyrosine kinases</a> (EC 2.7.10.2)</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/ABL_(gene)" title="ABL (gene)">ABL</a> family</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Abl_gene" class="mw-redirect" title="Abl gene">ABL1</a></li> <li><a href="/wiki/ABL2" title="ABL2">ARG</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/TNK2" title="TNK2">ACK</a> family</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/TNK2" title="TNK2">ACK1</a></li> <li><a href="/w/index.php?title=TNK1&action=edit&redlink=1" class="new" title="TNK1 (page does not exist)">TNK1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Tyrosine-protein_kinase_CSK" title="Tyrosine-protein kinase CSK">CSK</a> family</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/C-src_tyrosine_kinase" class="mw-redirect" title="C-src tyrosine kinase">CSK</a></li> <li><a href="/wiki/Megakaryocyte-associated_tyrosine_kinase" title="Megakaryocyte-associated tyrosine kinase">MATK</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/PTK2" title="PTK2">FAK</a> family</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/PTK2" title="PTK2">FAK</a></li> <li><a href="/wiki/PTK2B" title="PTK2B">PYK2</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Feline_sarcoma_oncogene" class="mw-redirect" title="Feline sarcoma oncogene">FES</a> family</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Feline_sarcoma_oncogene" class="mw-redirect" title="Feline sarcoma oncogene">FES</a></li> <li><a href="/wiki/FER_(gene)" title="FER (gene)">FER</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Fyn-related_kinase" title="Fyn-related kinase">FRK</a> family</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Fyn-related_kinase" title="Fyn-related kinase">FRK</a></li> <li><a href="/wiki/PTK6" title="PTK6">BRK</a></li> <li><a href="/w/index.php?title=SRMS_(gene)&action=edit&redlink=1" class="new" title="SRMS (gene) (page does not exist)">SRMS</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Janus_kinase" title="Janus kinase">JAK</a> family</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Janus_kinase_1" title="Janus kinase 1">JAK1</a></li> <li><a href="/wiki/Janus_kinase_2" title="Janus kinase 2">JAK2</a></li> <li><a href="/wiki/Janus_kinase_3" title="Janus kinase 3">JAK3</a></li> <li><a href="/wiki/Tyrosine_kinase_2" title="Tyrosine kinase 2">TYK2</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">SRC-A family</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Proto-oncogene_tyrosine-protein_kinase_Src" title="Proto-oncogene tyrosine-protein kinase Src">SRC</a></li> <li><a href="/wiki/FGR_(gene)" title="FGR (gene)">FGR</a></li> <li><a href="/wiki/FYN" title="FYN">FYN</a></li> <li><a href="/wiki/YES1" class="mw-redirect" title="YES1">YES1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">SRC-B family</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Tyrosine-protein_kinase_BLK" title="Tyrosine-protein kinase BLK">BLK</a></li> <li><a href="/wiki/HCK" title="HCK">HCK</a></li> <li><a href="/wiki/Lck" class="mw-redirect" title="Lck">LCK</a></li> <li><a href="/wiki/LYN" title="LYN">LYN</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/TEC_(gene)" title="TEC (gene)">TEC</a> family</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/TEC_(gene)" title="TEC (gene)">TEC</a></li> <li><a href="/wiki/BMX_(gene)" title="BMX (gene)">BMX</a></li> <li><a href="/wiki/Bruton%27s_tyrosine_kinase" title="Bruton's tyrosine kinase">BTK</a></li> <li><a href="/wiki/ITK_(gene)" title="ITK (gene)">ITK</a></li> <li><a href="/wiki/TXK_(gene)" title="TXK (gene)">TXK</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Tyrosine-protein_kinase_SYK" title="Tyrosine-protein kinase SYK">SYK</a> family</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Tyrosine-protein_kinase_SYK" title="Tyrosine-protein kinase SYK">SYK</a></li> <li><a href="/wiki/ZAP-70" class="mw-redirect" title="ZAP-70">ZAP70</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Enzymes" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Enzymes" title="Template:Enzymes"><abbr title="View 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href="/wiki/Enzyme_promiscuity" title="Enzyme promiscuity">Enzyme promiscuity</a></li> <li><a href="/wiki/Diffusion-limited_enzyme" title="Diffusion-limited enzyme">Diffusion-limited enzyme</a></li> <li><a href="/wiki/Cofactor_(biochemistry)" title="Cofactor (biochemistry)">Cofactor</a></li> <li><a href="/wiki/Enzyme_catalysis" title="Enzyme catalysis">Enzyme catalysis</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Regulation</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Allosteric_regulation" title="Allosteric regulation">Allosteric regulation</a></li> <li><a href="/wiki/Cooperativity" title="Cooperativity">Cooperativity</a></li> <li><a href="/wiki/Enzyme_inhibitor" title="Enzyme inhibitor">Enzyme inhibitor</a></li> <li><a href="/wiki/Enzyme_activator" title="Enzyme activator">Enzyme activator</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Classification</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC number</a></li> <li><a href="/wiki/Protein_superfamily" title="Protein superfamily">Enzyme superfamily</a></li> <li><a href="/wiki/Protein_family" title="Protein family">Enzyme family</a></li> <li><a href="/wiki/List_of_enzymes" title="List of enzymes">List of enzymes</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Kinetics</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Enzyme_kinetics" title="Enzyme kinetics">Enzyme kinetics</a></li> <li><a href="/wiki/Eadie%E2%80%93Hofstee_diagram" title="Eadie–Hofstee diagram">Eadie–Hofstee diagram</a></li> <li><a href="/wiki/Hanes%E2%80%93Woolf_plot" title="Hanes–Woolf plot">Hanes–Woolf plot</a></li> <li><a href="/wiki/Lineweaver%E2%80%93Burk_plot" title="Lineweaver–Burk plot">Lineweaver–Burk plot</a></li> <li><a href="/wiki/Michaelis%E2%80%93Menten_kinetics" title="Michaelis–Menten kinetics">Michaelis–Menten kinetics</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Types</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><b>EC1 <a href="/wiki/Oxidoreductase" title="Oxidoreductase">Oxidoreductases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_1)" title="List of EC numbers (EC 1)">list</a>)</li> <li><b>EC2 <a href="/wiki/Transferase" title="Transferase">Transferases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_2)" title="List of EC numbers (EC 2)">list</a>)</li> <li><b>EC3 <a href="/wiki/Hydrolase" title="Hydrolase">Hydrolases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_3)" title="List of EC numbers (EC 3)">list</a>)</li> <li><b>EC4 <a href="/wiki/Lyase" title="Lyase">Lyases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_4)" title="List of EC numbers (EC 4)">list</a>)</li> <li><b>EC5 <a href="/wiki/Isomerase" title="Isomerase">Isomerases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_5)" title="List of EC numbers (EC 5)">list</a>)</li> <li><b>EC6 <a href="/wiki/Ligase" title="Ligase">Ligases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_6)" title="List of EC numbers (EC 6)">list</a>)</li> <li><b>EC7 <a href="/wiki/Translocase" title="Translocase">Translocases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_7)" title="List of EC numbers (EC 7)">list</a>)</li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Growth_factor_receptor_modulators" style="padding:3px"><table class="nowraplinks hlist mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Growth_factor_receptor_modulators" title="Template:Growth factor receptor modulators"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Growth_factor_receptor_modulators" title="Template talk:Growth factor receptor modulators"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Growth_factor_receptor_modulators" title="Special:EditPage/Template:Growth factor receptor modulators"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Growth_factor_receptor_modulators" style="font-size:114%;margin:0 4em"><a href="/wiki/Growth_factor_receptor" title="Growth factor receptor">Growth factor receptor</a> <a href="/wiki/Receptor_modulator" title="Receptor modulator">modulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Angiopoietin_receptor" title="Angiopoietin receptor">Angiopoietin</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Angiopoietin_1" title="Angiopoietin 1">Angiopoietin 1</a></li> <li><a href="/wiki/Angiopoietin_4" class="mw-redirect" title="Angiopoietin 4">Angiopoietin 4</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/wiki/Angiopoietin_2" class="mw-redirect" title="Angiopoietin 2">Angiopoietin 2</a></li> <li><a href="/w/index.php?title=Angiopoietin_3&action=edit&redlink=1" class="new" title="Angiopoietin 3 (page does not exist)">Angiopoietin 3</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Altiratinib&action=edit&redlink=1" class="new" title="Altiratinib (page does not exist)">Altiratinib</a></li> <li><a href="/w/index.php?title=CE-245677&action=edit&redlink=1" class="new" title="CE-245677 (page does not exist)">CE-245677</a></li> <li><a href="/wiki/Rebastinib" class="mw-redirect" title="Rebastinib">Rebastinib</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Evinacumab" title="Evinacumab">Evinacumab</a> (against angiopoietin 3)</li> <li><a href="/wiki/Nesvacumab" title="Nesvacumab">Nesvacumab</a> (against angiopoietin 2)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Ciliary_neurotrophic_factor_receptor" title="Ciliary neurotrophic factor receptor">CNTF</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Axokine" class="mw-redirect" title="Axokine">Axokine</a></li> <li><a href="/wiki/Ciliary_neurotrophic_factor_receptor" title="Ciliary neurotrophic factor receptor">CNTF</a></li> <li><a href="/w/index.php?title=Dapiclermin&action=edit&redlink=1" class="new" title="Dapiclermin (page does not exist)">Dapiclermin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Epidermal_growth_factor_receptor" title="Epidermal growth factor receptor">EGF (ErbB)</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Epidermal_growth_factor_receptor" title="Epidermal growth factor receptor">EGF<br /><small>(ErbB1/HER1)</small></a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists</i>: <a href="/wiki/Amphiregulin" title="Amphiregulin">Amphiregulin</a></li> <li><a href="/wiki/Betacellulin" title="Betacellulin">Betacellulin</a></li> <li><a href="/wiki/Epidermal_growth_factor" title="Epidermal growth factor">EGF (urogastrone)</a></li> <li><a href="/wiki/Epigen" title="Epigen">Epigen</a></li> <li><a href="/wiki/Epiregulin" title="Epiregulin">Epiregulin</a></li> <li><a href="/wiki/Heparin-binding_EGF-like_growth_factor" title="Heparin-binding EGF-like growth factor">Heparin-binding EGF-like growth factor (HB-EGF)</a></li> <li><a href="/wiki/Murodermin" title="Murodermin">Murodermin</a></li> <li><a href="/wiki/Nepidermin" title="Nepidermin">Nepidermin</a></li> <li><a href="/wiki/Transforming_growth_factor_alpha" class="mw-redirect" title="Transforming growth factor alpha">Transforming growth factor alpha (TGFα)</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/wiki/Afatinib" title="Afatinib">Afatinib</a></li> <li><a href="/w/index.php?title=Agerafenib&action=edit&redlink=1" class="new" title="Agerafenib (page does not exist)">Agerafenib</a></li> <li><a href="/wiki/Brigatinib" title="Brigatinib">Brigatinib</a></li> <li><a href="/wiki/Canertinib" title="Canertinib">Canertinib</a></li> <li><a href="/wiki/Dacomitinib" title="Dacomitinib">Dacomitinib</a></li> <li><a href="/wiki/Erlotinib" title="Erlotinib">Erlotinib</a></li> <li><a href="/wiki/Gefitinib" title="Gefitinib">Gefitinib</a></li> <li><a href="/wiki/Grandinin" title="Grandinin">Grandinin</a></li> <li><a href="/wiki/Icotinib" title="Icotinib">Icotinib</a></li> <li><a href="/wiki/Lapatinib" title="Lapatinib">Lapatinib</a></li> <li><a href="/wiki/Neratinib" title="Neratinib">Neratinib</a></li> <li><a href="/wiki/Osimertinib" title="Osimertinib">Osimertinib</a></li> <li><a href="/wiki/Vandetanib" title="Vandetanib">Vandetanib</a></li> <li><a href="/w/index.php?title=WHI-P_154&action=edit&redlink=1" class="new" title="WHI-P 154 (page does not exist)">WHI-P 154</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Cetuximab" title="Cetuximab">Cetuximab</a></li> <li><a href="/w/index.php?title=Depatuxizumab&action=edit&redlink=1" class="new" title="Depatuxizumab (page does not exist)">Depatuxizumab</a></li> <li><a href="/wiki/Depatuxizumab_mafodotin" title="Depatuxizumab mafodotin">Depatuxizumab mafodotin</a></li> <li><a href="/wiki/Futuximab" title="Futuximab">Futuximab</a></li> <li><a href="/wiki/Imgatuzumab" title="Imgatuzumab">Imgatuzumab</a></li> <li><a href="/wiki/Matuzumab" title="Matuzumab">Matuzumab</a></li> <li><a href="/wiki/Necitumumab" title="Necitumumab">Necitumumab</a></li> <li><a href="/wiki/Nimotuzumab" title="Nimotuzumab">Nimotuzumab</a></li> <li><a href="/wiki/Panitumumab" title="Panitumumab">Panitumumab</a></li> <li><a href="/wiki/Zalutumumab" title="Zalutumumab">Zalutumumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/HER2/neu" class="mw-redirect" title="HER2/neu">ErbB2/HER2</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists</i>: <i>Unknown/none</i></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Ertumaxomab" title="Ertumaxomab">Ertumaxomab</a></li> <li><a href="/wiki/Pertuzumab" title="Pertuzumab">Pertuzumab</a></li> <li><a href="/wiki/Trastuzumab" title="Trastuzumab">Trastuzumab</a></li> <li><a href="/wiki/Trastuzumab_deruxtecan" title="Trastuzumab deruxtecan">Trastuzumab deruxtecan</a></li> <li><a href="/w/index.php?title=Trastuzumab_duocarmazine&action=edit&redlink=1" class="new" title="Trastuzumab duocarmazine (page does not exist)">Trastuzumab duocarmazine</a></li> <li><a href="/wiki/Trastuzumab_emtansine" title="Trastuzumab emtansine">Trastuzumab emtansine</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/wiki/Afatinib" title="Afatinib">Afatinib</a></li> <li><a href="/wiki/Lapatinib" title="Lapatinib">Lapatinib</a></li> <li><a href="/wiki/Mubritinib" title="Mubritinib">Mubritinib</a></li> <li><a href="/wiki/Neratinib" title="Neratinib">Neratinib</a></li> <li><a href="/wiki/Tucatinib" title="Tucatinib">Tucatinib</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/HER3" class="mw-redirect" title="HER3">ErbB3/HER3</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Neuregulin" title="Neuregulin">Neuregulins (heregulins)</a> (<a href="/wiki/Neuregulin-1" class="mw-redirect" title="Neuregulin-1">1</a>, <a href="/wiki/NRG2" class="mw-redirect" title="NRG2">2</a>, <a href="/wiki/CSPG5" title="CSPG5">6 (neuroglycan C)</a>)</li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Duligotumab" class="mw-redirect" title="Duligotumab">Duligotumab</a></li> <li><a href="/wiki/Patritumab" title="Patritumab">Patritumab</a></li> <li><a href="/wiki/Seribantumab" title="Seribantumab">Seribantumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/HER4" class="mw-redirect" title="HER4">ErbB4/HER4</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Betacellulin" title="Betacellulin">Betacellulin</a></li> <li><a href="/wiki/Epigen" title="Epigen">Epigen</a></li> <li><a href="/wiki/Heparin-binding_EGF-like_growth_factor" title="Heparin-binding EGF-like growth factor">Heparin-binding EGF-like growth factor (HB-EGF)</a></li> <li><a href="/wiki/Neuregulin" title="Neuregulin">Neuregulins (heregulins)</a> (<a href="/wiki/Neuregulin-1" class="mw-redirect" title="Neuregulin-1">1</a>, <a href="/wiki/NRG2" class="mw-redirect" title="NRG2">2</a>, <a href="/wiki/NRG3" class="mw-redirect" title="NRG3">3</a>, <a href="/wiki/NRG4" class="mw-redirect" title="NRG4">4</a>, <a href="/w/index.php?title=Tomoregulin&action=edit&redlink=1" class="new" title="Tomoregulin (page does not exist)">5 (tomoregulin, TMEFF)</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Fibroblast_growth_factor_receptor" title="Fibroblast growth factor receptor">FGF</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Fibroblast_growth_factor_receptor_1" title="Fibroblast growth factor receptor 1">FGFR1</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Ersofermin&action=edit&redlink=1" class="new" title="Ersofermin (page does not exist)">Ersofermin</a></li> <li><a href="/wiki/Fibroblast_growth_factor" title="Fibroblast growth factor">FGF</a> (<a href="/wiki/FGF1" class="mw-redirect" title="FGF1">1</a>, <a href="/wiki/FGF2" class="mw-redirect" title="FGF2">2 (bFGF)</a>, <a href="/wiki/FGF3" title="FGF3">3</a>, <a href="/wiki/FGF4" title="FGF4">4</a>, <a href="/wiki/FGF5" title="FGF5">5</a>, <a href="/wiki/FGF6" title="FGF6">6</a>, <a href="/wiki/FGF8" class="mw-redirect" title="FGF8">8</a>, <a href="/wiki/FGF10" title="FGF10">10 (KGF2)</a>, <a href="/wiki/FGF20" title="FGF20">20</a>)</li> <li><a href="/w/index.php?title=Repifermin&action=edit&redlink=1" class="new" title="Repifermin (page does not exist)">Repifermin</a></li> <li><a href="/wiki/Selpercatinib" title="Selpercatinib">Selpercatinib</a></li> <li><a href="/wiki/Trafermin" title="Trafermin">Trafermin</a></li> <li><a href="/w/index.php?title=Velafermin&action=edit&redlink=1" class="new" title="Velafermin (page does not exist)">Velafermin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a class="mw-selflink selflink">FGFR2</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Ersofermin&action=edit&redlink=1" class="new" title="Ersofermin (page does not exist)">Ersofermin</a></li> <li><a href="/wiki/Fibroblast_growth_factor" title="Fibroblast growth factor">FGF</a> (<a href="/wiki/FGF1" class="mw-redirect" title="FGF1">1</a>, <a href="/wiki/FGF2" class="mw-redirect" title="FGF2">2 (bFGF)</a>, <a href="/wiki/FGF3" title="FGF3">3</a>, <a href="/wiki/FGF4" title="FGF4">4</a>, <a href="/wiki/FGF5" title="FGF5">5</a>, <a href="/wiki/FGF6" title="FGF6">6</a>, <a href="/wiki/FGF7" title="FGF7">7</a> (<a href="/wiki/Keratinocyte_growth_factor" title="Keratinocyte growth factor">KGF</a>), <a href="/wiki/FGF8" class="mw-redirect" title="FGF8">8</a>, <a href="/wiki/FGF9" title="FGF9">9</a>, <a href="/wiki/FGF10" title="FGF10">10 (KGF2)</a>, <a href="/wiki/FGF17" title="FGF17">17</a>, <a href="/wiki/FGF18" title="FGF18">18</a>, <a href="/wiki/FGF22" title="FGF22">22</a>)</li> <li><a href="/wiki/Palifermin" title="Palifermin">Palifermin</a></li> <li><a href="/w/index.php?title=Repifermin&action=edit&redlink=1" class="new" title="Repifermin (page does not exist)">Repifermin</a></li> <li><a href="/wiki/Selpercatinib" title="Selpercatinib">Selpercatinib</a></li> <li><a href="/wiki/Sprifermin" title="Sprifermin">Sprifermin</a></li> <li><a href="/wiki/Trafermin" title="Trafermin">Trafermin</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/w/index.php?title=Aprutumab&action=edit&redlink=1" class="new" title="Aprutumab (page does not exist)">Aprutumab</a></li> <li><a href="/w/index.php?title=Aprutumab_ixadotin&action=edit&redlink=1" class="new" title="Aprutumab ixadotin (page does not exist)">Aprutumab ixadotin</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/wiki/Infigratinib" title="Infigratinib">Infigratinib</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Fibroblast_growth_factor_receptor_3" title="Fibroblast growth factor receptor 3">FGFR3</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Ersofermin&action=edit&redlink=1" class="new" title="Ersofermin (page does not exist)">Ersofermin</a></li> <li><a href="/wiki/Fibroblast_growth_factor" title="Fibroblast growth factor">FGF</a> (<a href="/wiki/FGF1" class="mw-redirect" title="FGF1">1</a>, <a href="/wiki/FGF2" class="mw-redirect" title="FGF2">2 (bFGF)</a>, <a href="/wiki/FGF4" title="FGF4">4</a>, <a href="/wiki/FGF8" class="mw-redirect" title="FGF8">8</a>, <a href="/wiki/FGF9" title="FGF9">9</a>, <a href="/wiki/FGF18" title="FGF18">18</a>, <a href="/wiki/FGF23" class="mw-redirect" title="FGF23">23</a>)</li> <li><a href="/wiki/Selpercatinib" title="Selpercatinib">Selpercatinib</a></li> <li><a href="/wiki/Sprifermin" title="Sprifermin">Sprifermin</a></li> <li><a href="/wiki/Trafermin" title="Trafermin">Trafermin</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Burosumab" title="Burosumab">Burosumab</a> (against FGF23)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Fibroblast_growth_factor_receptor_4" title="Fibroblast growth factor receptor 4">FGFR4</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Ersofermin&action=edit&redlink=1" class="new" title="Ersofermin (page does not exist)">Ersofermin</a></li> <li><a href="/wiki/Fibroblast_growth_factor" title="Fibroblast growth factor">FGF</a> (<a href="/wiki/FGF1" class="mw-redirect" title="FGF1">1</a>, <a href="/wiki/FGF2" class="mw-redirect" title="FGF2">2 (bFGF)</a>, <a href="/wiki/FGF4" title="FGF4">4</a>, <a href="/wiki/FGF6" title="FGF6">6</a>, <a href="/wiki/FGF8" class="mw-redirect" title="FGF8">8</a>, <a href="/wiki/FGF9" title="FGF9">9</a>, <a href="/wiki/FGF19" title="FGF19">19</a>)</li> <li><a href="/wiki/Trafermin" title="Trafermin">Trafermin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Unsorted</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/FGF15/19" title="FGF15/19">FGF15/19</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Hepatocyte_growth_factor_receptor" title="Hepatocyte growth factor receptor">HGF (c-Met)</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists</i>: <a href="/wiki/Fosgonimeton" title="Fosgonimeton">Fosgonimeton</a></li> <li><a href="/wiki/Hepatocyte_growth_factor" title="Hepatocyte growth factor">Hepatocyte growth factor</a></li></ul> <ul><li><i>Potentiators:</i> <a href="/wiki/Dihexa" title="Dihexa">Dihexa (PNB-0408)</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Altiratinib&action=edit&redlink=1" class="new" title="Altiratinib (page does not exist)">Altiratinib</a></li> <li><a href="/w/index.php?title=AM7_(drug)&action=edit&redlink=1" class="new" title="AM7 (drug) (page does not exist)">AM7</a></li> <li><a href="/w/index.php?title=AMG-458&action=edit&redlink=1" class="new" title="AMG-458 (page does not exist)">AMG-458</a></li> <li><a href="/w/index.php?title=Amuvatinib&action=edit&redlink=1" class="new" title="Amuvatinib (page does not exist)">Amuvatinib</a></li> <li><a href="/w/index.php?title=BMS-777607&action=edit&redlink=1" class="new" title="BMS-777607 (page does not exist)">BMS-777607</a></li> <li><a href="/wiki/Cabozantinib" title="Cabozantinib">Cabozantinib</a></li> <li><a href="/wiki/Capmatinib" title="Capmatinib">Capmatinib</a></li> <li><a href="/wiki/Crizotinib" title="Crizotinib">Crizotinib</a></li> <li><a href="/wiki/Foretinib" title="Foretinib">Foretinib</a></li> <li><a href="/w/index.php?title=Golvatinib&action=edit&redlink=1" class="new" title="Golvatinib (page does not exist)">Golvatinib</a></li> <li><a href="/w/index.php?title=INCB28060&action=edit&redlink=1" class="new" title="INCB28060 (page does not exist)">INCB28060</a></li> <li><a href="/w/index.php?title=JNJ-38877605&action=edit&redlink=1" class="new" title="JNJ-38877605 (page does not exist)">JNJ-38877605</a></li> <li><a href="/wiki/K252a" title="K252a">K252a</a></li> <li><a href="/w/index.php?title=MK-2461&action=edit&redlink=1" class="new" title="MK-2461 (page does not exist)">MK-2461</a></li> <li><a href="/w/index.php?title=PF-04217903&action=edit&redlink=1" class="new" title="PF-04217903 (page does not exist)">PF-04217903</a></li> <li><a href="/w/index.php?title=PF-2341066&action=edit&redlink=1" class="new" title="PF-2341066 (page does not exist)">PF-2341066</a></li> <li><a href="/w/index.php?title=PHA-665752&action=edit&redlink=1" class="new" title="PHA-665752 (page does not exist)">PHA-665752</a></li> <li><a href="/w/index.php?title=SU-11274&action=edit&redlink=1" class="new" title="SU-11274 (page does not exist)">SU-11274</a></li> <li><a href="/wiki/Tivantinib" title="Tivantinib">Tivantinib</a></li> <li><a href="/wiki/Volitinib" class="mw-redirect" title="Volitinib">Volitinib</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Emibetuzumab" title="Emibetuzumab">Emibetuzumab</a></li> <li><a href="/wiki/Ficlatuzumab" title="Ficlatuzumab">Ficlatuzumab</a></li> <li><a href="/wiki/Flanvotumab" title="Flanvotumab">Flanvotumab</a></li> <li><a href="/wiki/Onartuzumab" title="Onartuzumab">Onartuzumab</a></li> <li><a href="/wiki/Rilotumumab" title="Rilotumumab">Rilotumumab</a></li> <li><a href="/w/index.php?title=Telisotuzumab&action=edit&redlink=1" class="new" title="Telisotuzumab (page does not exist)">Telisotuzumab</a></li> <li><a href="/wiki/Telisotuzumab_vedotin" title="Telisotuzumab vedotin">Telisotuzumab vedotin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Somatomedin_receptor" title="Somatomedin receptor">IGF</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Insulin-like_growth_factor_1_receptor" title="Insulin-like growth factor 1 receptor">IGF-1</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists</i>: <a href="/wiki/Des(1-3)IGF-1" title="Des(1-3)IGF-1">des(1-3)IGF-1</a></li> <li><a href="/wiki/Insulin-like_growth_factor_1" title="Insulin-like growth factor 1">Insulin-like growth factor-1 (somatomedin C)</a></li> <li><a href="/wiki/IGF-1_LR3" title="IGF-1 LR3">IGF-1 LR3</a></li> <li><a href="/wiki/Insulin-like_growth_factor_2" title="Insulin-like growth factor 2">Insulin-like growth factor-2 (somatomedin A)</a></li> <li><a href="/wiki/Insulin" title="Insulin">Insulin</a></li> <li><a href="/wiki/Mecasermin" title="Mecasermin">Mecasermin</a></li> <li><a href="/wiki/Mecasermin_rinfabate" title="Mecasermin rinfabate">Mecasermin rinfabate</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=BMS-754807&action=edit&redlink=1" class="new" title="BMS-754807 (page does not exist)">BMS-754807</a></li> <li><a href="/wiki/Linsitinib" title="Linsitinib">Linsitinib</a></li> <li><a href="/w/index.php?title=NVP-ADW742&action=edit&redlink=1" class="new" title="NVP-ADW742 (page does not exist)">NVP-ADW742</a></li> <li><a href="/w/index.php?title=NVP-AEW541&action=edit&redlink=1" class="new" title="NVP-AEW541 (page does not exist)">NVP-AEW541</a></li> <li><a href="/w/index.php?title=OSl-906&action=edit&redlink=1" class="new" title="OSl-906 (page does not exist)">OSl-906</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/w/index.php?title=AVE-1642&action=edit&redlink=1" class="new" title="AVE-1642 (page does not exist)">AVE-1642</a></li> <li><a href="/wiki/Cixutumumab" title="Cixutumumab">Cixutumumab</a></li> <li><a href="/wiki/Dalotuzumab" title="Dalotuzumab">Dalotuzumab</a></li> <li><a href="/wiki/Figitumumab" title="Figitumumab">Figitumumab</a></li> <li><a href="/wiki/Ganitumab" title="Ganitumab">Ganitumab</a></li> <li><a href="/wiki/Robatumumab" title="Robatumumab">Robatumumab</a></li> <li><a href="/w/index.php?title=R1507&action=edit&redlink=1" class="new" title="R1507 (page does not exist)">R1507</a></li> <li><a href="/wiki/Teprotumumab" title="Teprotumumab">Teprotumumab</a></li> <li><a href="/w/index.php?title=Xentuzumab&action=edit&redlink=1" class="new" title="Xentuzumab (page does not exist)">Xentuzumab</a> (against IGF-1 and IGF-2)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Insulin-like_growth_factor_2_receptor" title="Insulin-like growth factor 2 receptor">IGF-2</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists</i>: <a href="/wiki/Insulin-like_growth_factor_2" title="Insulin-like growth factor 2">Insulin-like growth factor-2 (somatomedin A)</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Dusigitumab" title="Dusigitumab">Dusigitumab</a></li> <li><a href="/w/index.php?title=Xentuzumab&action=edit&redlink=1" class="new" title="Xentuzumab (page does not exist)">Xentuzumab</a> (against IGF-1 and IGF-2)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Binding proteins:</i> <a href="/wiki/Insulin-like_growth_factor-binding_protein" title="Insulin-like growth factor-binding protein">IGFBP</a> (<a href="/wiki/IGFBP1" title="IGFBP1">1</a>, <a href="/wiki/IGFBP2" title="IGFBP2">2</a>, <a href="/wiki/IGFBP3" title="IGFBP3">3</a>, <a href="/wiki/IGFBP4" title="IGFBP4">4</a>, <a href="/wiki/IGFBP5" title="IGFBP5">5</a>, <a href="/wiki/IGFBP6" title="IGFBP6">6</a>, <a href="/wiki/IGFBP7" title="IGFBP7">7</a>)</li></ul> <ul><li><i>Cleavage products/derivatives with unknown target:</i> <a href="/w/index.php?title=Glypromate&action=edit&redlink=1" class="new" title="Glypromate (page does not exist)">Glypromate (GPE, (1-3)IGF-1)</a></li> <li><a href="/wiki/Trofinetide" title="Trofinetide">Trofinetide</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Low-affinity_nerve_growth_factor_receptor" title="Low-affinity nerve growth factor receptor">LNGF (p75<sup>NTR</sup>)</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Brain-derived_neurotrophic_factor" title="Brain-derived neurotrophic factor">BDNF</a></li> <li><a href="/wiki/BNN-20" title="BNN-20">BNN-20</a></li> <li><a href="/wiki/BNN-27" title="BNN-27">BNN-27</a></li> <li><a href="/wiki/Cenegermin" title="Cenegermin">Cenegermin</a></li> <li><a href="/wiki/Dehydroepiandrosterone" title="Dehydroepiandrosterone">DHEA</a></li> <li><a href="/wiki/Dehydroepiandrosterone_sulfate" title="Dehydroepiandrosterone sulfate">DHEA-S</a></li> <li><a href="/wiki/Nerve_growth_factor" title="Nerve growth factor">NGF</a></li> <li><a href="/wiki/Neurotrophin-3" title="Neurotrophin-3">NT-3</a></li> <li><a href="/wiki/Neurotrophin-4" title="Neurotrophin-4">NT-4</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/w/index.php?title=ALE-0540&action=edit&redlink=1" class="new" title="ALE-0540 (page does not exist)">ALE-0540</a></li> <li><a href="/wiki/Dexamethasone" title="Dexamethasone">Dexamethasone</a></li> <li><a href="/w/index.php?title=EVT-901&action=edit&redlink=1" class="new" title="EVT-901 (page does not exist)">EVT-901 (SAR-127963)</a></li> <li><a href="/wiki/Testosterone" title="Testosterone">Testosterone</a></li></ul> <ul><li><i>Antibodies:</i> <i>Against NGF:</i> <a href="/w/index.php?title=ABT-110&action=edit&redlink=1" class="new" title="ABT-110 (page does not exist)">ABT-110 (PG110)</a></li> <li><a href="/w/index.php?title=ASP-6294&action=edit&redlink=1" class="new" title="ASP-6294 (page does not exist)">ASP-6294</a></li> <li><a href="/wiki/Fasinumab" title="Fasinumab">Fasinumab</a></li> <li><a href="/wiki/Frunevetmab" title="Frunevetmab">Frunevetmab</a></li> <li><a href="/wiki/Fulranumab" title="Fulranumab">Fulranumab</a></li> <li><a href="/w/index.php?title=MEDI-578&action=edit&redlink=1" class="new" title="MEDI-578 (page does not exist)">MEDI-578</a></li> <li><a href="/w/index.php?title=Ranevetmab&action=edit&redlink=1" class="new" title="Ranevetmab (page does not exist)">Ranevetmab</a></li> <li><a href="/wiki/Tanezumab" title="Tanezumab">Tanezumab</a></li></ul> <ul><li><i>Aptamers:</i> <i>Against NGF:</i> <a href="/w/index.php?title=RBM-004&action=edit&redlink=1" class="new" title="RBM-004 (page does not exist)">RBM-004</a></li></ul> <ul><li><i>Decoy receptors:</i> <a href="/w/index.php?title=LEVI-04&action=edit&redlink=1" class="new" title="LEVI-04 (page does not exist)">LEVI-04 (p75<sup>NTR</sup>-Fc)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Platelet-derived_growth_factor_receptor" title="Platelet-derived growth factor receptor">PDGF</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Becaplermin" title="Becaplermin">Becaplermin</a></li> <li><a href="/wiki/Platelet-derived_growth_factor" title="Platelet-derived growth factor">Platelet-derived growth factor</a> (<a href="/wiki/PDGFA" title="PDGFA">A</a>, <a href="/wiki/PDGFB" title="PDGFB">B</a>, <a href="/wiki/PDGFC" title="PDGFC">C</a>, <a href="/wiki/PDGFD" title="PDGFD">D</a>)</li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Agerafenib&action=edit&redlink=1" class="new" title="Agerafenib (page does not exist)">Agerafenib</a></li> <li><a href="/wiki/Avapritinib" title="Avapritinib">Avapritinib</a></li> <li><a href="/wiki/Axitinib" title="Axitinib">Axitinib</a></li> <li><a href="/wiki/Crenolanib" title="Crenolanib">Crenolanib</a></li> <li><a href="/wiki/Imatinib" title="Imatinib">Imatinib</a></li> <li><a href="/wiki/Lenvatinib" title="Lenvatinib">Lenvatinib</a></li> <li><a href="/wiki/Masitinib" title="Masitinib">Masitinib</a></li> <li><a href="/wiki/Motesanib" title="Motesanib">Motesanib</a></li> <li><a href="/wiki/Nintedanib" title="Nintedanib">Nintedanib</a></li> <li><a href="/wiki/Pazopanib" title="Pazopanib">Pazopanib</a></li> <li><a href="/wiki/Radotinib" title="Radotinib">Radotinib</a></li> <li><a href="/wiki/Quizartinib" title="Quizartinib">Quizartinib</a></li> <li><a href="/wiki/Ripretinib" title="Ripretinib">Ripretinib</a></li> <li><a href="/wiki/Sunitinib" title="Sunitinib">Sunitinib</a></li> <li><a href="/wiki/Sorafenib" title="Sorafenib">Sorafenib</a></li> <li><a href="/wiki/Toceranib" title="Toceranib">Toceranib</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Olaratumab" title="Olaratumab">Olaratumab</a></li> <li><a href="/wiki/Ramucirumab" title="Ramucirumab">Ramucirumab</a></li> <li><a href="/wiki/Tovetumab" title="Tovetumab">Tovetumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/RET_proto-oncogene" title="RET proto-oncogene">RET (GFL)</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/GFR%CE%B11" class="mw-redirect" title="GFRα1">GFRα1</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Glial_cell_line-derived_neurotrophic_factor" title="Glial cell line-derived neurotrophic factor">Glial cell line-derived neurotrophic factor (GDNF)</a></li> <li><a href="/w/index.php?title=Liatermin&action=edit&redlink=1" class="new" title="Liatermin (page does not exist)">Liatermin</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/wiki/Vandetanib" title="Vandetanib">Vandetanib</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/GFR%CE%B12" class="mw-redirect" title="GFRα2">GFRα2</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Neurturin" title="Neurturin">Neurturin (NRTN)</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/wiki/Vandetanib" title="Vandetanib">Vandetanib</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/GFR%CE%B13" class="mw-redirect" title="GFRα3">GFRα3</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Artemin" title="Artemin">Artemin (ARTN)</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/wiki/Vandetanib" title="Vandetanib">Vandetanib</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/GFR%CE%B14" class="mw-redirect" title="GFRα4">GFRα4</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Persephin" title="Persephin">Persephin (PSPN)</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/wiki/Vandetanib" title="Vandetanib">Vandetanib</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Unsorted</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Agerafenib&action=edit&redlink=1" class="new" title="Agerafenib (page does not exist)">Agerafenib</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CD117" class="mw-redirect" title="CD117">SCF (c-Kit)</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Ancestim" title="Ancestim">Ancestim</a></li> <li><a href="/wiki/Stem_cell_factor" title="Stem cell factor">Stem cell factor</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Agerafenib&action=edit&redlink=1" class="new" title="Agerafenib (page does not exist)">Agerafenib</a></li> <li><a href="/wiki/Axitinib" title="Axitinib">Axitinib</a></li> <li><a href="/wiki/Dasatinib" title="Dasatinib">Dasatinib</a></li> <li><a href="/wiki/Imatinib" title="Imatinib">Imatinib</a></li> <li><a href="/wiki/Masitinib" title="Masitinib">Masitinib</a></li> <li><a href="/wiki/Nilotinib" title="Nilotinib">Nilotinib</a></li> <li><a href="/wiki/Pazopanib" title="Pazopanib">Pazopanib</a></li> <li><a href="/wiki/Quizartinib" title="Quizartinib">Quizartinib</a></li> <li><a href="/wiki/Sorafenib" title="Sorafenib">Sorafenib</a></li> <li><a href="/wiki/Sunitinib" title="Sunitinib">Sunitinib</a></li> <li><a href="/wiki/Toceranib" title="Toceranib">Toceranib</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Transforming_growth_factor_beta_receptor" class="mw-redirect" title="Transforming growth factor beta receptor">TGFβ</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>See <a href="/wiki/Template:TGF%CE%B2_receptor_superfamily_modulators" title="Template:TGFβ receptor superfamily modulators">here</a> instead.</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Trk_receptor" title="Trk receptor">Trk</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/TrkA_receptor" class="mw-redirect" title="TrkA receptor">TrkA</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Amitriptyline" title="Amitriptyline">Amitriptyline</a></li> <li><a href="/wiki/BNN-20" title="BNN-20">BNN-20</a></li> <li><a href="/wiki/BNN-27" title="BNN-27">BNN-27</a></li> <li><a href="/wiki/Cenegermin" title="Cenegermin">Cenegermin</a></li> <li><a href="/wiki/Dehydroepiandrosterone" title="Dehydroepiandrosterone">DHEA</a></li> <li><a href="/wiki/Dehydroepiandrosterone_sulfate" title="Dehydroepiandrosterone sulfate">DHEA-S</a></li> <li><a href="/w/index.php?title=Gambogic_amide&action=edit&redlink=1" class="new" title="Gambogic amide (page does not exist)">Gambogic amide</a></li> <li><a href="/wiki/Nerve_growth_factor" title="Nerve growth factor">NGF</a></li> <li><a href="/wiki/Tavilermide" title="Tavilermide">Tavilermide</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/w/index.php?title=ALE-0540&action=edit&redlink=1" class="new" title="ALE-0540 (page does not exist)">ALE-0540</a></li> <li><a href="/wiki/Dexamethasone" title="Dexamethasone">Dexamethasone</a></li> <li><a href="/wiki/FX007" class="mw-redirect" title="FX007">FX007</a></li> <li><a href="/wiki/Testosterone" title="Testosterone">Testosterone</a></li></ul> <ul><li><i>Negative allosteric modulators:</i> <a href="/w/index.php?title=VM-902A&action=edit&redlink=1" class="new" title="VM-902A (page does not exist)">VM-902A</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Altiratinib&action=edit&redlink=1" class="new" title="Altiratinib (page does not exist)">Altiratinib</a></li> <li><a href="/w/index.php?title=AZD-6918&action=edit&redlink=1" class="new" title="AZD-6918 (page does not exist)">AZD-6918</a></li> <li><a href="/w/index.php?title=CE-245677&action=edit&redlink=1" class="new" title="CE-245677 (page does not exist)">CE-245677</a></li> <li><a href="/w/index.php?title=CH-7057288&action=edit&redlink=1" class="new" title="CH-7057288 (page does not exist)">CH-7057288</a></li> <li><a href="/w/index.php?title=DS-6051&action=edit&redlink=1" class="new" title="DS-6051 (page does not exist)">DS-6051</a></li> <li><a href="/wiki/Entrectinib" title="Entrectinib">Entrectinib</a></li> <li><a href="/w/index.php?title=GZ-389988&action=edit&redlink=1" class="new" title="GZ-389988 (page does not exist)">GZ-389988</a></li> <li><a href="/wiki/K252a" title="K252a">K252a</a></li> <li><a href="/wiki/Larotrectinib" title="Larotrectinib">Larotrectinib</a></li> <li><a href="/wiki/Lestaurtinib" title="Lestaurtinib">Lestaurtinib</a></li> <li><a href="/w/index.php?title=Milciclib&action=edit&redlink=1" class="new" title="Milciclib (page does not exist)">Milciclib</a></li> <li><a href="/w/index.php?title=ONO-4474&action=edit&redlink=1" class="new" title="ONO-4474 (page does not exist)">ONO-4474</a></li> <li><a href="/w/index.php?title=ONO-5390556&action=edit&redlink=1" class="new" title="ONO-5390556 (page does not exist)">ONO-5390556</a></li> <li><a href="/w/index.php?title=PLX-7486&action=edit&redlink=1" class="new" title="PLX-7486 (page does not exist)">PLX-7486</a></li> <li><a href="/wiki/Rebastinib" class="mw-redirect" title="Rebastinib">Rebastinib</a></li> <li><a href="/w/index.php?title=SNA-120&action=edit&redlink=1" class="new" title="SNA-120 (page does not exist)">SNA-120 (pegylated K252a)</a>)</li></ul> <ul><li><i>Antibodies:</i> <i>Against TrkA:</i> <a href="/w/index.php?title=GBR-900&action=edit&redlink=1" class="new" title="GBR-900 (page does not exist)">GBR-900</a>; <i>Against NGF:</i> <a href="/w/index.php?title=ABT-110&action=edit&redlink=1" class="new" title="ABT-110 (page does not exist)">ABT-110 (PG110)</a></li> <li><a href="/w/index.php?title=ASP-6294&action=edit&redlink=1" class="new" title="ASP-6294 (page does not exist)">ASP-6294</a></li> <li><a href="/wiki/Fasinumab" title="Fasinumab">Fasinumab</a></li> <li><a href="/wiki/Frunevetmab" title="Frunevetmab">Frunevetmab</a></li> <li><a href="/wiki/Fulranumab" title="Fulranumab">Fulranumab</a></li> <li><a href="/w/index.php?title=MEDI-578&action=edit&redlink=1" class="new" title="MEDI-578 (page does not exist)">MEDI-578</a></li> <li><a href="/w/index.php?title=Ranevetmab&action=edit&redlink=1" class="new" title="Ranevetmab (page does not exist)">Ranevetmab</a></li> <li><a href="/wiki/Tanezumab" title="Tanezumab">Tanezumab</a></li></ul> <ul><li><i>Aptamers:</i> <i>Against NGF:</i> <a href="/w/index.php?title=RBM-004&action=edit&redlink=1" class="new" title="RBM-004 (page does not exist)">RBM-004</a></li></ul> <ul><li><i>Decoy receptors:</i> <a href="/w/index.php?title=ReN-1820&action=edit&redlink=1" class="new" title="ReN-1820 (page does not exist)">ReN-1820 (TrkAd5)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/TrkB_receptor" class="mw-redirect" title="TrkB receptor">TrkB</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=3,7-Dihydroxyflavone&action=edit&redlink=1" class="new" title="3,7-Dihydroxyflavone (page does not exist)">3,7-DHF</a></li> <li><a href="/w/index.php?title=3,7,8,2%27-Tetrahydroxyflavone&action=edit&redlink=1" class="new" title="3,7,8,2'-Tetrahydroxyflavone (page does not exist)">3,7,8,2'-THF</a></li> <li><a href="/wiki/4%27-Dimethylamino-7,8-dihydroxyflavone" class="mw-redirect" title="4'-Dimethylamino-7,8-dihydroxyflavone">4'-DMA-7,8-DHF</a></li> <li><a href="/w/index.php?title=7,3%E2%80%B2-Dihydroxyflavone&action=edit&redlink=1" class="new" title="7,3′-Dihydroxyflavone (page does not exist)">7,3'-DHF</a></li> <li><a href="/wiki/7,8-Dihydroxyflavone" class="mw-redirect" title="7,8-Dihydroxyflavone">7,8-DHF</a></li> <li><a href="/w/index.php?title=7,8,2%27-Trihydroxyflavone&action=edit&redlink=1" class="new" title="7,8,2'-Trihydroxyflavone (page does not exist)">7,8,2'-THF</a></li> <li><a href="/wiki/7,8,3%27-Trihydroxyflavone" title="7,8,3'-Trihydroxyflavone">7,8,3'-THF</a></li> <li><a href="/wiki/Amitriptyline" title="Amitriptyline">Amitriptyline</a></li> <li><a href="/wiki/Brain-derived_neurotrophic_factor" title="Brain-derived neurotrophic factor">BDNF</a></li> <li><a href="/wiki/BNN-20" title="BNN-20">BNN-20</a></li> <li><a href="/wiki/Deoxygedunin" title="Deoxygedunin">Deoxygedunin</a></li> <li><a href="/wiki/Deprenyl" title="Deprenyl">Deprenyl</a></li> <li><a href="/wiki/Diosmetin" title="Diosmetin">Diosmetin</a></li> <li><a href="/w/index.php?title=DMAQ-B1&action=edit&redlink=1" class="new" title="DMAQ-B1 (page does not exist)">DMAQ-B1</a></li> <li><a href="/wiki/HIOC" title="HIOC">HIOC</a></li> <li><a href="/wiki/LM22A-4" title="LM22A-4">LM22A-4</a></li> <li><a href="/wiki/N-Acetylserotonin" title="N-Acetylserotonin">N-Acetylserotonin</a></li> <li><a href="/wiki/Neurotrophin-3" title="Neurotrophin-3">NT-3</a></li> <li><a href="/wiki/Neurotrophin-4" title="Neurotrophin-4">NT-4</a></li> <li><a href="/wiki/Norwogonin" title="Norwogonin">Norwogonin (5,7,8-THF)</a></li> <li><a href="/wiki/R7_(drug)" title="R7 (drug)">R7</a></li> <li><a href="/wiki/R13_(drug)" title="R13 (drug)">R13</a></li> <li><a href="/w/index.php?title=TDP6&action=edit&redlink=1" class="new" title="TDP6 (page does not exist)">TDP6</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/wiki/ANA-12" title="ANA-12">ANA-12</a></li> <li><a href="/wiki/Cyclotraxin_B" title="Cyclotraxin B">Cyclotraxin B</a></li> <li><a href="/wiki/Gossypetin" title="Gossypetin">Gossypetin (3,5,7,8,3',4'-HHF)</a></li></ul> <ul><li><i>Ligands:</i> <a href="/wiki/Dehydroepiandrosterone" title="Dehydroepiandrosterone">DHEA</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Altiratinib&action=edit&redlink=1" class="new" title="Altiratinib (page does not exist)">Altiratinib</a></li> <li><a href="/w/index.php?title=AZD-6918&action=edit&redlink=1" class="new" title="AZD-6918 (page does not exist)">AZD-6918</a></li> <li><a href="/w/index.php?title=CE-245677&action=edit&redlink=1" class="new" title="CE-245677 (page does not exist)">CE-245677</a></li> <li><a href="/w/index.php?title=CH-7057288&action=edit&redlink=1" class="new" title="CH-7057288 (page does not exist)">CH-7057288</a></li> <li><a href="/w/index.php?title=DS-6051&action=edit&redlink=1" class="new" title="DS-6051 (page does not exist)">DS-6051</a></li> <li><a href="/wiki/Entrectinib" title="Entrectinib">Entrectinib</a></li> <li><a href="/w/index.php?title=GZ-389988&action=edit&redlink=1" class="new" title="GZ-389988 (page does not exist)">GZ-389988</a></li> <li><a href="/wiki/K252a" title="K252a">K252a</a></li> <li><a href="/wiki/Larotrectinib" title="Larotrectinib">Larotrectinib</a></li> <li><a href="/wiki/Lestaurtinib" title="Lestaurtinib">Lestaurtinib</a></li> <li><a href="/w/index.php?title=ONO-4474&action=edit&redlink=1" class="new" title="ONO-4474 (page does not exist)">ONO-4474</a></li> <li><a href="/w/index.php?title=ONO-5390556&action=edit&redlink=1" class="new" title="ONO-5390556 (page does not exist)">ONO-5390556</a></li> <li><a href="/w/index.php?title=PLX-7486&action=edit&redlink=1" class="new" title="PLX-7486 (page does not exist)">PLX-7486</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/TrkC_receptor" class="mw-redirect" title="TrkC receptor">TrkC</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/BNN-20" title="BNN-20">BNN-20</a></li> <li><a href="/wiki/Dehydroepiandrosterone" title="Dehydroepiandrosterone">DHEA</a></li> <li><a href="/wiki/Neurotrophin-3" title="Neurotrophin-3">NT-3</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Altiratinib&action=edit&redlink=1" class="new" title="Altiratinib (page does not exist)">Altiratinib</a></li> <li><a href="/w/index.php?title=AZD-6918&action=edit&redlink=1" class="new" title="AZD-6918 (page does not exist)">AZD-6918</a></li> <li><a href="/w/index.php?title=CE-245677&action=edit&redlink=1" class="new" title="CE-245677 (page does not exist)">CE-245677</a></li> <li><a href="/w/index.php?title=CH-7057288&action=edit&redlink=1" class="new" title="CH-7057288 (page does not exist)">CH-7057288</a></li> <li><a href="/w/index.php?title=DS-6051&action=edit&redlink=1" class="new" title="DS-6051 (page does not exist)">DS-6051</a></li> <li><a href="/wiki/Entrectinib" title="Entrectinib">Entrectinib</a></li> <li><a href="/w/index.php?title=GZ-389988&action=edit&redlink=1" class="new" title="GZ-389988 (page does not exist)">GZ-389988</a></li> <li><a href="/wiki/K252a" title="K252a">K252a</a></li> <li><a href="/wiki/Larotrectinib" title="Larotrectinib">Larotrectinib</a></li> <li><a href="/wiki/Lestaurtinib" title="Lestaurtinib">Lestaurtinib</a></li> <li><a href="/w/index.php?title=ONO-4474&action=edit&redlink=1" class="new" title="ONO-4474 (page does not exist)">ONO-4474</a></li> <li><a href="/w/index.php?title=ONO-5390556&action=edit&redlink=1" class="new" title="ONO-5390556 (page does not exist)">ONO-5390556</a></li> <li><a href="/w/index.php?title=PLX-7486&action=edit&redlink=1" class="new" title="PLX-7486 (page does not exist)">PLX-7486</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Vascular_endothelial_growth_factor_receptor" class="mw-redirect" title="Vascular endothelial growth factor receptor">VEGF</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Placental_growth_factor" title="Placental growth factor">Placental growth factor (PGF)</a></li> <li><a href="/wiki/Ripretinib" title="Ripretinib">Ripretinib</a></li> <li><a href="/w/index.php?title=Telbermin&action=edit&redlink=1" class="new" title="Telbermin (page does not exist)">Telbermin</a></li> <li><a href="/wiki/Vascular_endothelial_growth_factor" title="Vascular endothelial growth factor">VEGF</a> (<a href="/wiki/Vascular_endothelial_growth_factor_A" title="Vascular endothelial growth factor A">A</a>, <a href="/wiki/Vascular_endothelial_growth_factor_B" title="Vascular endothelial growth factor B">B</a>, <a href="/wiki/Vascular_endothelial_growth_factor_C" title="Vascular endothelial growth factor C">C</a>, <a href="/wiki/Vascular_endothelial_growth_factor_D" class="mw-redirect" title="Vascular endothelial growth factor D">D (FIGF)</a>)</li></ul> <ul><li><i>Allosteric modulators:</i> <a href="/wiki/Cyclotraxin_B" title="Cyclotraxin B">Cyclotraxin B</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Agerafenib&action=edit&redlink=1" class="new" title="Agerafenib (page does not exist)">Agerafenib</a></li> <li><a href="/w/index.php?title=Altiratinib&action=edit&redlink=1" class="new" title="Altiratinib (page does not exist)">Altiratinib</a></li> <li><a href="/wiki/Axitinib" title="Axitinib">Axitinib</a></li> <li><a href="/wiki/Cabozantinib" title="Cabozantinib">Cabozantinib</a></li> <li><a href="/wiki/Cediranib" title="Cediranib">Cediranib</a></li> <li><a href="/wiki/Fruquintinib" title="Fruquintinib">Fruquintinib</a></li> <li><a href="/wiki/Lapatinib" title="Lapatinib">Lapatinib</a></li> <li><a href="/wiki/Lenvatinib" title="Lenvatinib">Lenvatinib</a></li> <li><a href="/wiki/Motesanib" title="Motesanib">Motesanib</a></li> <li><a href="/wiki/Nintedanib" title="Nintedanib">Nintedanib</a></li> <li><a href="/wiki/Pazopanib" title="Pazopanib">Pazopanib</a></li> <li><a href="/wiki/Pegaptanib" title="Pegaptanib">Pegaptanib</a></li> <li><a href="/wiki/Rebastinib" class="mw-redirect" title="Rebastinib">Rebastinib</a></li> <li><a href="/wiki/Regorafenib" title="Regorafenib">Regorafenib</a></li> <li><a href="/wiki/Semaxanib" title="Semaxanib">Semaxanib</a></li> <li><a href="/wiki/Sorafenib" title="Sorafenib">Sorafenib</a></li> <li><a href="/wiki/Sunitinib" title="Sunitinib">Sunitinib</a></li> <li><a href="/wiki/Toceranib" title="Toceranib">Toceranib</a></li> <li><a href="/wiki/Tivozanib" title="Tivozanib">Tivozanib</a></li> <li><a href="/wiki/Vandetanib" title="Vandetanib">Vandetanib</a></li> <li><a href="/w/index.php?title=WHI-P_154&action=edit&redlink=1" class="new" title="WHI-P 154 (page does not exist)">WHI-P 154</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Alacizumab_pegol" title="Alacizumab pegol">Alacizumab pegol</a></li> <li><a href="/wiki/Bevacizumab" title="Bevacizumab">Bevacizumab</a></li> <li><a href="/wiki/Icrucumab" title="Icrucumab">Icrucumab</a></li> <li><a href="/wiki/Ramucirumab" title="Ramucirumab">Ramucirumab</a></li> <li><a href="/wiki/Ranibizumab" title="Ranibizumab">Ranibizumab</a></li></ul> <ul><li><i>Decoy receptors:</i> <a href="/wiki/Aflibercept" title="Aflibercept">Aflibercept</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Additional growth factors:</i> <a href="/wiki/Adrenomedullin" title="Adrenomedullin">Adrenomedullin</a></li> <li><a href="/wiki/Colony-stimulating_factor" title="Colony-stimulating factor">Colony-stimulating factors</a> (see <a href="/wiki/Template:Cytokine_receptor_modulators" title="Template:Cytokine receptor modulators">here</a> instead)</li> <li><a href="/wiki/Connective_tissue_growth_factor" class="mw-redirect" title="Connective tissue growth factor">Connective tissue growth factor (CTGF)</a></li> <li><a href="/wiki/Ephrin" title="Ephrin">Ephrins</a> (<a href="/wiki/EFNA1" class="mw-redirect" title="EFNA1">A1</a>, <a href="/wiki/EFNA2" class="mw-redirect" title="EFNA2">A2</a>, <a href="/wiki/EFNA3" class="mw-redirect" title="EFNA3">A3</a>, <a href="/wiki/EFNA4" class="mw-redirect" title="EFNA4">A4</a>, <a href="/wiki/EFNA5" class="mw-redirect" title="EFNA5">A5</a>, <a href="/wiki/EFNB1" class="mw-redirect" title="EFNB1">B1</a>, <a href="/wiki/EFNB2" class="mw-redirect" title="EFNB2">B2</a>, <a href="/wiki/EFNB3" class="mw-redirect" title="EFNB3">B3</a>)</li> <li><a href="/wiki/Erythropoietin" title="Erythropoietin">Erythropoietin</a> (see <a href="/wiki/Template:Cytokine_receptor_modulators" title="Template:Cytokine receptor modulators">here</a> instead)</li> <li><a href="/wiki/Glucose-6-phosphate_isomerase" title="Glucose-6-phosphate isomerase">Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF)</a></li> <li><a href="/wiki/Glia_maturation_factor" title="Glia maturation factor">Glia maturation factor (GMF)</a></li> <li><a href="/wiki/Hepatoma-derived_growth_factor" title="Hepatoma-derived growth factor">Hepatoma-derived growth factor (HDGF)</a></li> <li><a href="/wiki/Interleukin" title="Interleukin">Interleukins</a>/<a href="/wiki/T-cell_growth_factor" title="T-cell growth factor">T-cell growth factors</a> (see <a href="/wiki/Template:Cytokine_receptor_modulators" title="Template:Cytokine receptor modulators">here</a> instead)</li> <li><a href="/wiki/Leukemia_inhibitory_factor" title="Leukemia inhibitory factor">Leukemia inhibitory factor (LIF)</a></li> <li><a href="/wiki/Macrophage-stimulating_protein" class="mw-redirect" title="Macrophage-stimulating protein">Macrophage-stimulating protein (MSP; HLP, HGFLP)</a></li> <li><a href="/wiki/Midkine" title="Midkine">Midkine (NEGF2)</a></li> <li><a href="/wiki/Migration-stimulating_factor" class="mw-redirect" title="Migration-stimulating factor">Migration-stimulating factor (MSF; PRG4)</a></li> <li><a href="/wiki/Oncomodulin" title="Oncomodulin">Oncomodulin</a></li> <li><a href="/wiki/Pituitary_adenylate_cyclase-activating_peptide" title="Pituitary adenylate cyclase-activating peptide">Pituitary adenylate cyclase-activating peptide (PACAP)</a></li> <li><a href="/wiki/Pleiotrophin" title="Pleiotrophin">Pleiotrophin</a></li> <li><a href="/wiki/Renalase" title="Renalase">Renalase</a></li> <li><a href="/wiki/Thrombopoietin" title="Thrombopoietin">Thrombopoietin</a> (see <a href="/wiki/Template:Cytokine_receptor_modulators" title="Template:Cytokine receptor modulators">here</a> instead)</li> <li><a href="/wiki/Wnt_signaling_pathway" title="Wnt signaling pathway">Wnt signaling proteins</a></li></ul> <ul><li><i>Additional growth factor receptor modulators:</i> <a href="/wiki/Cerebrolysin" title="Cerebrolysin">Cerebrolysin</a> (neurotrophin mixture)</li></ul> </div></td></tr></tbody></table></div> <style data-mw-deduplicate="TemplateStyles:r1130092004">.mw-parser-output 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