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</div> </div> </div> </div> </div> <div class="content-wrapper content-wrapper-vc-enabled"> <div class="container"><div class="row"> <div class="col-sm-12 col-md-12 col-lg-8 col-xl-9"> <div id="primary" class="content-area"> <main id="main" class="site-main"> <article id="post-14404" class="post-14404 page type-page status-publish hentry"> <div class="entry-content"> <div class="wpb-content-wrapper"><div class="vc_row wpb_row vc_row-fluid row-background-none"><div class="wpb_column vc_column_container vc_col-sm-12 row-background-none"><div class="vc_column-inner vc_custom_1576086745957"><div class="wpb_wrapper"><div class="ult-spacer spacer-67bef69d8a8f6" data-id="67bef69d8a8f6" data-height="50" data-height-mobile="50" data-height-tab="50" data-height-tab-portrait="" data-height-mobile-landscape="" style="clear:both;display:block;"></div> <div class="wpb_text_column wpb_content_element" > <div class="wpb_wrapper"> <h2>THE COMPREHENSIVE LIST OF CBD STUDIES AND REVIEWS</h2> <p>CBD Studies and Reviews help us understand the science behind CBD. We often wonder the effectiveness or efficacy of CBD (Cannabidiol). We read articles about how Cannabidiol will help with this ailment or have benefits for that condition. But most of the CBD studies and reviews are either difficult to find or buried in research journals, deep inside hard to find medical websites.</p> <p></p> <p> So we’ve done the work for you… .</p> <h5></h5> <p> <strong>A definitive and comprehensive list of CBD research and CBD studies from the top medical organizations around the world:</strong></p> <h5></h5> <h5><picture><source data-lazy-srcset="https://cannaffex.ca/core/webp-express/webp-images/uploads/2022/01/cbd-research-studies.jpg.webp 945w, https://cannaffex.ca/core/webp-express/webp-images/uploads/2022/01/cbd-research-studies-600x336.jpg.webp 600w, https://cannaffex.ca/core/webp-express/webp-images/uploads/2022/01/cbd-research-studies-300x168.jpg.webp 300w, https://cannaffex.ca/core/webp-express/webp-images/uploads/2022/01/cbd-research-studies-768x430.jpg.webp 768w" sizes="(max-width: 945px) 100vw, 945px" type="image/webp"><img fetchpriority="high" decoding="async" class="aligncenter size-full wp-image-24948 webpexpress-processed" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%20945%20529'%3E%3C/svg%3E" alt="CBD Research Studies" width="945" height="529" data-lazy-srcset="https://cannaffex.ca/storage/2022/01/cbd-research-studies.jpg 945w, https://cannaffex.ca/storage/2022/01/cbd-research-studies-600x336.jpg 600w, https://cannaffex.ca/storage/2022/01/cbd-research-studies-300x168.jpg 300w, https://cannaffex.ca/storage/2022/01/cbd-research-studies-768x430.jpg 768w" data-lazy-sizes="(max-width: 945px) 100vw, 945px" data-lazy-src="https://cannaffex.ca/storage/2022/01/cbd-research-studies.jpg"><noscript><img fetchpriority="high" decoding="async" class="aligncenter size-full wp-image-24948 webpexpress-processed" src="https://cannaffex.ca/storage/2022/01/cbd-research-studies.jpg" alt="CBD Research Studies" width="945" height="529" srcset="https://cannaffex.ca/storage/2022/01/cbd-research-studies.jpg 945w, https://cannaffex.ca/storage/2022/01/cbd-research-studies-600x336.jpg 600w, https://cannaffex.ca/storage/2022/01/cbd-research-studies-300x168.jpg 300w, https://cannaffex.ca/storage/2022/01/cbd-research-studies-768x430.jpg 768w" sizes="(max-width: 945px) 100vw, 945px"></noscript></picture></h5> <h5></h5> <h5 class="wp-block-media-text__media"> </h5> <h5 class="wp-block-media-text__content"></h5> <p><a href="https://www.health.harvard.edu/blog/cannabidiol-cbd-what-we-know-and-what-we-dont-2018082414476" data-wpel-link="external" rel="nofollow external noopener noreferrer">Harvard Medical School</a></p> <p><a href="https://www.ncbi.nlm.nih.gov/pubmed/31775230" data-wpel-link="external" rel="nofollow external noopener noreferrer">Articles and Listings from the US National Center for Biotechnology Information (NCBI)</a></p> <p><a href="http://www.who.int/medicines/access/controlled-substances/5.2_CBD.pdf" data-wpel-link="external" rel="nofollow external noopener noreferrer">World Health Organization (WHO)</a></p> <p><a href="https://clinicaltrials.gov/ct2/results?cond=&term=cbd&cntry=&state=&city=&dist=" data-wpel-link="external" rel="nofollow external noopener noreferrer">US Library of Medicine posted ongoing Clinical Trials</a></p> <p><a href="https://search.nih.gov/search?utf8=%E2%9C%93&affiliate=nih&query=CBD&commit=Search" data-wpel-link="external" rel="nofollow external noopener noreferrer">U.S. National Institutes of Health</a></p> <h3></h3> <h5></h5> <h5></h5> <h5></h5> <p> Listed below are the many different CBD Studies and Reviews as well as the numerous Abstracts and Articles on current CBD (Cannabidiol) research today. They cover a great number of different conditions and ailments that CBD has reportedly been able to help.</p> <h5></h5> <p><strong>Now you can make your own conclusions based on facts!</strong></p> <h5></h5> </div> </div> </div></div></div></div><div id="vc_row_1578000188996-a967642c-01d7" class="vc_row wpb_row vc_row-fluid vc_custom_1578000299755 row-background-none"><div class="wpb_column vc_column_container vc_col-sm-12 row-background-none" id="vc_col_1578000189001-513b10de-87f3"><div class="vc_column-inner "><div class="wpb_wrapper"><div class="ult-spacer spacer-67bef69d8af02" data-id="67bef69d8af02" data-height="30" data-height-mobile="30" data-height-tab="30" data-height-tab-portrait="" data-height-mobile-landscape="" style="clear:both;display:block;"></div> <div class="wpb_text_column wpb_content_element" > <div class="wpb_wrapper"> <p><em>*search studies by ailment</em></p> <h5></h5> <form id="form" action="https://cannaffex.ca" autocomplete="off" class="bkb-live-search-form"> <div id="suggest" class="bkb_filter_container"> <input type="text" size="25" value="" id="s" name="s" class="s" placeholder="Search Keywords ..... " data-search-box-unique-id="442883998" data-search_limit="10" data-search_only_title="1" data-search_both_tc="0"/> <span class="bkbm-btn-clear bkbm-dn"></span> <div class="suggestionsBox" id="suggestions_442883998" style="display: none;"> <div class="suggestionList" id="suggestionsList_442883998">   </div> </div> </div> </form> </div> </div> </div></div></div></div><div id="vc_row_1576085502695-902707ed-2e40" class="vc_row wpb_row vc_row-fluid row-background-none"><div class="wpb_column vc_column_container vc_col-sm-6 row-background-none" id="vc_col_1576085502697-604d3a7f-1613"><div class="vc_column-inner "><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element" > <div class="wpb_wrapper"> <hr /> <div class="bkbm-grid bkbm-grid-pad bwl-kb bwl-row-cols-2"><div class="bkbcol-1-1"><h2 class="bwl-kb-category-title"><a href="https://cannaffex.ca/bwl-knowledge-base/bwl-knowledge-base-category/a/" title="A" data-wpel-link="internal"><i class="fa fa-file-o"></i> A</a></h2><div class="smk_accordion acc_with_icon" id="bkb_accordion_3194992375"><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Acquired Hypothyroidism</h4></div> <div class="acc_content" style="display: none;"><ul> <li><strong>NCBI 2017 Study:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/27799014/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Effect of Marijuana Use on Thyroid Function and Autoimmunity.</a></li> <li><strong>Bio Med Research 2015 study: </strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619873/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Clinical Significance of Cannabinoid Receptors CB1 and CB2 Expression in Human Malignant and Benign Thyroid Lesions</a></li> <li><strong>NCBI 2009 Study:</strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2630898/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Type 1 Cannabinoid Receptor-Containing Axons Innervate Hypophysiotropic Thyrotropin-Releasing Hormone-Synthesizing Neurons</a></li> <li><strong>NCBI 2002 Study:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/12153749/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Evidence for functional CB1 cannabinoid receptor expressed in the rat thyroid.</a></li> </ul>  </div> </div><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Addiction</h4></div> <div class="acc_content" style="display: none;"><p><strong>Molecules 2019 Study:</strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680550/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabidiol Treatment Might Promote Resilience to Cocaine and Methamphetamine Use Disorders: A Review of Possible Mechanisms</a></p> <p>Journal of Dual Diagnosis 2019 Study: <a href="https://pubmed.ncbi.nlm.nih.gov/31479625/" data-wpel-link="external" rel="nofollow external noopener noreferrer">The Effectiveness of Cannabinoids in the Treatment of Posttraumatic Stress Disorder (PTSD): A Systematic Review.</a></p> <p><strong>NCBI 2019 Abstract: </strong><a href="https://pubmed.ncbi.nlm.nih.gov/31837295/" data-wpel-link="external" rel="nofollow external noopener noreferrer">The influence of carboxylesterase 1 polymorphism and cannabidiol on the hepatic metabolism of heroin.</a></p> <p><strong>Neurotherapuetics 2015 Study:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/26269227/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Early Phase in the Development of Cannabidiol as a Treatment for Addiction: Opioid Relapse Takes Initial Center Stage.</a></p> </div> </div><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>AIDS and related Ailments</h4></div> <div class="acc_content" style="display: none;"><ul> <li><strong><span style="color: #000000;">NCBI 2007 Abstract: </span></strong><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202504/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabinoids in health and disease</a></li> <li><strong>JPSM 2005 Article:</strong> <a href="https://www.jpsmjournal.com/article/S0885-3924(05)00063-1/fulltext" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabis Use in HIV for Pain and Other Medical Symptoms</a></li> <li><strong>NCBI 2019 Abstract:</strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340429/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Oral cannabinoids in people living with HIV on effective antiretroviral therapy</a></li> </ul> </div> </div><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Alzheimer’s Disease</h4></div> <div class="acc_content" style="display: none;"><ul> <li><strong>Journal of Pharmacopunture 2019 Study:</strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970569/" rel="”nofollow” nofollow external noopener noreferrer" data-wpel-link="external">A Review on Studies of Marijuana for Alzheimer’s Disease – Focusing on CBD, THC</a></li> <li><strong>Front Pharmacol 2017 Abstract: </strong><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289988/" rel="”nofollow” nofollow external noopener noreferrer" data-wpel-link="external">Evidence for Therapeutic Properties of Cannabidiol (CBD) for Alzheimer’s Disease</a></li> <li><strong>Science Direct 2016 Article: </strong><a href="https://www.sciencedirect.com/science/article/pii/S0028390816300879" rel="”nofollow” nofollow external noopener noreferrer" data-wpel-link="external"><span class="title-text">Stimulation of brain glucose uptake by cannabinoid CB<sub>2</sub> receptors and its therapeutic potential in Alzheimer’s disease</span></a></li> <li><strong><strong>Nature 2016 Abstract: </strong></strong><a href="https://www.nature.com/articles/npjamd201612--" rel="”nofollow” nofollow external noopener noreferrer" data-wpel-link="external">Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids</a></li> <li><strong>Semantic Scholar 2016 Study:</strong> <a href="https://www.semanticscholar.org/paper/Activity-of-muscarinic%2C-galanin-and-cannabinoid-in-Manuel-Lombardero/695c03fa498f20efd72e989e47fdf80044d1ab53" rel="”nofollow” nofollow external noopener noreferrer" data-wpel-link="external"> Activity of muscarinic, galanin and cannabinoid receptors in the prodromal and advanced stages in the triple transgenic mice model of Alzheimer’s disease</a></li> <li><strong><strong>CNS Drugs 2015 Abstract: </strong></strong><a href="https://link.springer.com/article/10.1007/s40263-015-0270-y" rel="”nofollow” nofollow external noopener noreferrer" data-wpel-link="external">Cannabinoids for the Treatment of Agitation and Aggression in Alzheimer’s Disease</a><strong><strong><br /> </strong></strong><strong>ASCPT 2015 Abstract:</strong> <a href="https://ascpt.onlinelibrary.wiley.com/doi/abs/10.1002/cpt.117" rel="”nofollow” nofollow external noopener noreferrer" data-wpel-link="external">Cannabinoids in late‐onset Alzheimer’s disease</a></li> <li><strong>Frontiers in Pharmacology 2014 Article: </strong><a href="https://www.frontiersin.org/articles/10.3389/fphar.2014.00037/full" rel="”nofollow” nofollow external noopener noreferrer" data-wpel-link="external">Cannabinoids for treatment of Alzheimer’s disease: moving toward the clinic</a></li> <li><strong>Journal of Neuroinflammation 2012 Abstract: </strong><a href="https://jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-9-8" rel="”nofollow” nofollow external noopener noreferrer" data-wpel-link="external">Prolonged oral cannabinoid administration prevents neuroinflammation, lowers β-amyloid levels and improves cognitive performance in Tg APP 2576 mice</a></li> <li><strong>Molecular Pharmacology 2011 Abstract:</strong> <a href="https://molpharm.aspetjournals.org/content/79/6/964" rel="”nofollow” nofollow external noopener noreferrer" data-wpel-link="external">Cannabidiol and Other Cannabinoids Reduce Microglial Activation In Vitro and In Vivo: Relevance to Alzheimer’s Disease</a></li> <li><strong>British Pharmacological Society 2009 Abstract: </strong><a href="https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1038/sj.bjp.0707446" rel="”nofollow” nofollow external noopener noreferrer" data-wpel-link="external">Alzheimer’s disease; taking the edge off with cannabinoids</a></li> <li><strong>NCBI 2005 Abstract: </strong><a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=Retrieve&dopt=Abstract&list_uids=16183560" rel="”nofollow” nofollow external noopener noreferrer" data-wpel-link="external">Cannabinol delays symptom onset in SOD1</a></li> <li><strong>JNeurosci 2005 Study: </strong><a href="https://www.jneurosci.org/content/25/8/1904.short" rel="”nofollow” nofollow external noopener noreferrer" data-wpel-link="external">Prevention of Alzheimer’s Disease Pathology by Cannabinoids</a></li> <li><strong>Science Direct 2004 Abstract:</strong> <a href="https://www.sciencedirect.com/science/article/abs/pii/S0024320504005600?via%3Dihub" rel="”nofollow” nofollow external noopener noreferrer" data-wpel-link="external"><span class="title-text">Role of the endocannabinoid system in Alzheimer’s disease: New perspectives</span></a></li> </ul> </div> </div><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Amyotrophic Lateral Sclerosis (ALS)</h4></div> <div class="acc_content" style="display: none;"><ul> <li><strong>NCBI 2019 Study:</strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732193/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Real world experience of patients with amyotrophic lateral sclerosis (ALS) in the treatment of spasticity using tetrahydrocannabinol:cannabidiol (THC:CBD)</a></li> <li><strong><strong>Journal of General Practice 2017 Study: </strong></strong><a href="https://www.hilarispublisher.com/open-access/comedication-with-cannabidiol-may-slow-down-the-progression-of-motorneuron-disease-a-case-report-2329-9126-1000316.pdf" data-wpel-link="external" rel="nofollow external noopener noreferrer">Co-medication with Cannabidiol May Slow Down the Progression of Motor Neuron Disease</a></li> <li><strong>NCBI 2010 Abstract:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/20439484/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabis and amyotrophic lateral sclerosis: hypothetical and practical applications, and a call for clinical trials.</a></li> <li><strong><strong>NCBI 2016 Abstract: </strong></strong><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270417/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Can cannabinoids be a potential therapeutic tool in amyotrophic lateral sclerosis?</a></li> <li><strong>Rense.com Article: </strong><a href="https://rense.com//general51/lou.htm" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabis Relieves Lou Gehrigs Symptoms_ New Study</a></li> </ul> </div> </div><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Anxiety Disorders</h4></div> <div class="acc_content" style="display: none;"><p><strong>NCBI 2019 Case study: </strong><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326553/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabidiol in Anxiety and Sleep: A Large Case Series</a></p> <p><strong>NPR 2018 Article:</strong> <a href="https://www.npr.org/sections/health-shots/2018/04/23/604307015/anxiety-relief-without-the-high-new-studies-on-cbd-a-cannabis-extract" data-wpel-link="external" rel="nofollow external noopener noreferrer">Anxiety Relief Without The High? New Studies On CBD, A Cannabis Extract</a></p> <p><strong><span style="color: #000000;">British Journal of Pharmacology: 2017 Study: </span></strong><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595771/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabidiol regulation of emotion and emotional memory processing: relevance for treating anxiety‐related and substance abuse disorders</a></p> <p><strong><span style="color: #000000;">NCBI 2015 Publication: </span></strong><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604171/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabidiol as a Potential Treatment for Anxiety Disorders</a></p> <p><strong>NCBI 2019 Case study: </strong><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326553/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabidiol in Anxiety and Sleep: A Large Case Series</a></p> <p><strong>NCBI 2010 Abstract:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/19616342/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Endocannabinoid-mediated modulation of stress responses: physiological and pathophysiological significance.</a></p> <p><strong><span role="menubar">Neuropsychopharmacology.</span> 2013 Study: </strong><a href="https://pubmed.ncbi.nlm.nih.gov/23426383/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabinoids ameliorate impairments induced by chronic stress to synaptic plasticity and short-term memory.</a></p> <p><strong>NCBI 2011 Study:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/21307846/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking in Treatment-Naïve Social Phobia Patients.</a></p> <p><strong>NCBI 2011 Report:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/20829306/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report.</a></p> <p><strong>Anxiety.org 2019 Article: </strong><a href="https://www.anxiety.org/is-cannabis-an-effective-treatment-for-anxiety-what-research-shows" data-wpel-link="external" rel="nofollow external noopener noreferrer">Is cannabis an effective treatment for anxiety disorders?</a></p> </div> </div><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Arthritis</h4></div> <div class="acc_content" style="display: none;"><ul> <li><strong>NCBI 2015 Study:</strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851925/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis</a></li> <li><strong><strong>US National Libreary of Medicine 2018 Study: </strong></strong><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222489/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabinoid Delivery Systems for Pain and Inflammation Treatment</a></li> <li><strong>NCBI 2017 Study:</strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5690292/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis</a></li> <li><strong>NCBI 2014 Abstract:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/24494687/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Involvement of the endocannabinoid system in osteoarthritis pain.</a></li> <li><strong><strong>NCBI 2011 Study: </strong></strong><a href="https://pubmed.ncbi.nlm.nih.gov/21683763/" data-wpel-link="external" rel="nofollow external noopener noreferrer">The abnormal cannabidiol analogue O-1602 reduces nociception in a rat model of acute arthritis via the putative cannabinoid receptor GPR55.</a></li> <li><strong>NCBI 2000 Study:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/10920191/" data-wpel-link="external" rel="nofollow external noopener noreferrer">The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis.</a></li> <li><strong>Medical News Today Article:</strong> <a href="https://www.medicalnewstoday.com/articles/319796" data-wpel-link="external" rel="nofollow external noopener noreferrer">Can CBD oil relieve arthritis pain? </a></li> <li><strong>NORML Article:</strong> <a href="https://norml.org/marijuana/library/recent-medical-marijuana-research/rheumatoid-arthritis/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Rheumatoid Arthritis</a></li> </ul> </div> </div><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Asthma</h4></div> <div class="acc_content" style="display: none;"><ul> <li><strong>NCBI 2015 Study:</strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458548/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Evaluation of Serum Cytokines Levels and the Role of Cannabidiol Treatment in Animal Model of Asthma</a></li> <li><strong>NCBI 2012 Study:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/22420307/" data-wpel-link="external" rel="nofollow external noopener noreferrer">The role of cannabinoids in inflammatory modulation of allergic respiratory disorders, inflammatory pain and ischemic stroke.</a></li> <li><strong>European Journal of Pharmacology 2019 Study:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/30481497/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabidiol reduces airway inflammation and fibrosis in experimental allergic asthma.</a></li> <li><strong>Hindawi report of 2015 Study:</strong> <a href="https://www.hindawi.com/journals/mi/2015/538670/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Evaluation of Serum Cytokines Levels and the Role of Cannabidiol Treatment in Animal Model of Asthma</a></li> <li><strong><strong>Journal of Cellular and Molecular Medicine 2008 Study: </strong></strong><a href="https://pubmed.ncbi.nlm.nih.gov/18266975/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Activation of cannabinoid receptors prevents antigen-induced asthma-like reaction in guinea pigs.</a></li> <li><strong>NCBI 1978 Abstract:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/656294/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Bronchodilator effect of delta1-tetrahydrocannabinol.</a></li> <li><strong>CBD Insider 2018 Article:</strong> <a href="https://thecbdinsider.com/knowledge-center/how-cbd-is-providing-hope-for-asthma-patients/" data-wpel-link="external" rel="nofollow external noopener noreferrer">How CBD is Providing Hope for Asthma Patients</a></li> </ul> </div> </div><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Attention Deficit Hyperactivity Disorder (ADD/ADHD)</h4></div> <div class="acc_content" style="display: none;"><ul> <li><strong>NCBI 2017 Study:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/28576350/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabinoids in attention-deficit/hyperactivity disorder: A randomised-controlled trial.</a></li> <li><strong>Mediacal Cannibas 2018 Case report: </strong> <a href="https://karger.com/mca/article/1/2/112/188841/Medical-Cannabis-for-Adult-Attention-Deficit" data-wpel-link="external" rel="nofollow external noopener noreferrer">Medical Cannabis for Adult Attention Deficit Hyperactivity Disorder</a></li> <li><strong>NCBI 2012 Study:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/22495620/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabidiol and clozapine reverse MK-801-induced deficits in social interaction and hyperactivity in Sprague-Dawley rats.</a></li> <li><strong>Frontiers on Pharmacology 2019 Research Article:</strong> <a href="https://www.frontiersin.org/articles/10.3389/fphar.2019.00309/full" data-wpel-link="external" rel="nofollow external noopener noreferrer">Attenuation of Novelty-Induced Hyperactivity of <i>Gria1-/-</i> Mice by Cannabidiol and Hippocampal Inhibitory Chemogenetics</a></li> <li><strong>University of Washington 2017 Study:</strong> <a href="https://adai.uw.edu/pubs/pdf/2017mjadhd.pdf" data-wpel-link="external" rel="nofollow external noopener noreferrer">Effects of Marijuana on Mental Health</a></li> </ul> </div> </div><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Autoimmune Disease</h4></div> <div class="acc_content" style="display: none;"><ul> <li><strong>Gastrojournal 2019 Report:</strong><a href="https://www.gastrojournal.org/article/S0016-5085(19)40410-1/fulltext" data-wpel-link="external" rel="nofollow external noopener noreferrer"> Use of Cannabidiol (CBD Oil) in Autoimmune Hepatitis</a></li> <li><strong><strong>NCBI 2013 Study: </strong></strong><a href="https://pubmed.ncbi.nlm.nih.gov/23892791/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabinoids decrease the th17 inflammatory autoimmune phenotype.</a></li> <li><strong>NCBI 2010 Study:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/19457575/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression.</a></li> <li><strong>NCBI 2006 Abstract:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/16981823/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Targeting the CB2 receptor for immune modulation.</a></li> <li><strong>Journal of Neurology 2016 Review:</strong> <a href="https://www.jneurology.com/articles/cannabis-and-autoimmunity--the-neurologic-perspective-a-brief-review.html" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabis and Autoimmunity – The Neurologic Perspective: A Brief Review</a></li> </ul> </div> </div></div></div></div> </div> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-6 row-background-none" id="vc_col_1576351705637-6d039388-35b8"><div class="vc_column-inner "><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element" > <div class="wpb_wrapper"> <hr /> <div class="bkbm-grid bkbm-grid-pad bwl-kb bwl-row-cols-2"><div class="bkbcol-1-1"><h2 class="bwl-kb-category-title"><a href="https://cannaffex.ca/bwl-knowledge-base/bwl-knowledge-base-category/b/" title="B" data-wpel-link="internal"><i class="fa fa-file-o"></i> B</a></h2><div class="smk_accordion acc_with_icon" id="bkb_accordion_706133109"><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Back Pain</h4></div> <div class="acc_content" style="display: none;"><p><strong>Spine Health 2019 Article: </strong> <a href="https://www.spine-health.com/treatment/alternative-care/understanding-cbd-cannabidiol-back-pain" data-wpel-link="external" rel="nofollow external noopener noreferrer">Understanding CBD (Cannabidiol) for Back Pain</a></p> <p><strong>Remedy Review 2019 Article: </strong><a href="https://www.remedyreview.com/health/cbd-back-pain/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Can CBD provide relief from chronic back pain?</a></p> <p><strong>Molecules 2018 Study: </strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222489/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabinoid Delivery Systems for Pain and Inflammation Treatment</a></p> <p><strong>NCBI 2014 Study: </strong><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269422/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Protective Effects of Cannabidiol on Lesion-Induced Intervertebral Disc Degeneration</a></p> <p><strong>NCBI 2008 Abstract:</strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2503660/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabinoids in the management of difficult to treat pain</a></p> </div> </div><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Bi Polar Disorder</h4></div> <div class="acc_content" style="display: none;"><p><strong>Front Immunol 2018 Study:</strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161644/" rel="”noopener” nofollow external noopener noreferrer" data-wpel-link="external">Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD)</a></p> <p><strong>PsychCentral 2019 Article:</strong> <a href="https://psychcentral.com/bipolar/cbd-and-bipolar-disorder" rel="”noopener” nofollow external noopener noreferrer" data-wpel-link="external">CBD Oil for Depression, Schizophrenia, ADHD, PTSD, Anxiety, Bipolar & More</a></p> <p><strong>US. National Library of Medicine 2017 Study: </strong> <a href="https://clinicaltrials.gov/ct2/show/NCT03310593" rel="”noopener” nofollow external noopener noreferrer" data-wpel-link="external">Cannabidiol as an Adjunctive Treatment for Bipolar Depression (CBDBD)</a></p> <p><strong>University of Washington 2017 Study:</strong> <a href="https://adai.uw.edu/pubs/pdf/2017mjbipolar.pdf" rel="”noopener” nofollow external noopener noreferrer" data-wpel-link="external">Effects of Marijuana on Mental Health</a> (Bipolar Disorder)</p> <p><strong>PLOS ONE 2016 Abstract:</strong> <a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0157060" rel="”noopener” nofollow external noopener noreferrer" data-wpel-link="external">A Pilot Investigation of the Impact of Bipolar Disorder and Marijuana Use on Cognitive Function and Mood</a></p> <p><strong>Psychedelictimes 2016 Article:</strong> <a href="https://psychedelictimes.com/when-treating-bipolar-disorder-with-cannabis-research-suggests-the-amount-of-cbd-may-be-key/" rel="”noopener” nofollow external noopener noreferrer" data-wpel-link="external">When Treating Bipolar Disorder with Cannabis, Research Suggests the Amount of CBD May Be Key</a></p> <div id="e3c018c7-8573-4acd-93ae-0ff4b1f3baf3" class="widget general-html none widget-none widget-compact-all"> <div class="wrapped "> <div class="widget-body body body-none body-compact-all"><strong><strong>Journal of Psychopharmacology 2005 Abstract: </strong></strong><a href="https://journals.sagepub.com/doi/abs/10.1177/0269881105051541" rel="”noopener” nofollow external noopener noreferrer" data-wpel-link="external">Cannabinoids in bipolar affective disorder: a review and discussion of their therapeutic potential</a></div> <div></div> </div> <div></div> </div> <p> </p> </div> </div><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Bone Health</h4></div> <div class="acc_content" style="display: none;"><p><strong>NCBI 2019 Study: </strong><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940789/" data-wpel-link="external" rel="nofollow external noopener noreferrer">A Novel, Tumor-Induced Osteoclastogenesis Pathway Insensitive to Denosumab but Interfered by Cannabidiol</a></p> <p><strong>Journal of Bone and Mineral Research 2015 Abstract: </strong><a href="https://asbmr.onlinelibrary.wiley.com/doi/full/10.1002/jbmr.2513" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabidiol, a Major Non‐Psychotropic Cannabis Constituent Enhances Fracture Healing and Stimulates Lysyl Hydroxylase Activity in Osteoblasts</a></p> <p><strong>Science Direct 2016 Study: </strong><a href="https://www.sciencedirect.com/science/article/abs/pii/S1350453316301485" data-wpel-link="external" rel="nofollow external noopener noreferrer"><span class="title-text">Mechanical and material properties of cortical and trabecular bone from cannabinoid receptor-1-null (<em>Cnr1<sup>−/−</sup></em>) mice</span></a></p> <p><strong>Bio Med Research 2015 Article: </strong><a href="https://www.hindawi.com/journals/bmri/2015/874982/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Activation of Cannabinoid Receptor 2 Enhances Osteogenic Differentiation of Bone Marrow Derived Mesenchymal Stem Cells</a></p> <p><strong>Plos One 2014 Study: </strong><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269422/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Protective Effects of Cannabidiol on Lesion-Induced Intervertebral Disc Degeneration</a></p> <p><strong>British Journal of Pharmacology 2012 Abstract: </strong><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423262/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabinoids and bone: endocannabinoids modulate human osteoclast function <em>in vitro</em></a></p> <p><strong>Frontiers in Endocrinology 2012 Abstract: </strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499879/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Role of cannabinoids in the regulation of bone remodeling</a></p> <p><strong>Faseb Journal 2008 Abstract: </strong><a href="https://faseb.onlinelibrary.wiley.com/doi/epdf/10.1096/fj.06-7957com" data-wpel-link="external" rel="nofollow external noopener noreferrer">The cannabinoid CB1 receptor regulates bone formation by modulating adrenergic signaling</a></p> <p><strong>NCBI 2006 Abstract: </strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1334629/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Peripheral cannabinoid receptor, CB2, regulates bone mass</a></p> </div> </div><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Brain Cancer (Tumor)</h4></div> <div class="acc_content" style="display: none;"><p><strong>NCBI 2019 Study: </strong><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650324/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Regulation of human glioblastoma cell death by combined treatment of cannabidiol, γ-radiation and small molecule inhibitors of cell signaling pathways</a></p> <p><strong>NCBI 2018 Study:</strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964193/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabinoids in Glioblastoma Therapy: New Applications for Old Drugs </a></p> <p><strong>Cancer Med 2018 Study:</strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852356/" data-wpel-link="external" rel="nofollow external noopener noreferrer">The current state and future perspectives of cannabinoids in cancer biology</a></p> <p><strong>Neuro-Oncology Practice 2017 Article: </strong><a href="https://academic.oup.com/nop/article/4/3/151/2918616" data-wpel-link="external" rel="nofollow external noopener noreferrer">The use of cannabis in supportive care and treatment of brain tumor</a></p> <p><strong>Science Daily 2014 Article: </strong><a href="https://www.sciencedaily.com/releases/2014/11/141114085629.htm" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabis extract can have dramatic effect on brain cancer</a></p> <p> </p> </div> </div><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Bulimia</h4></div> <div class="acc_content" style="display: none;"><p><strong>Behavioural Pharmacology 2012 Abstract: </strong></a><a href="https://pubmed.ncbi.nlm.nih.gov/22785439/" data-wpel-link="external" rel="nofollow external noopener noreferrer">The role of the endocannabinoid system in eating disorders</a></p> <p><strong>NCBI 2005 Study:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/15856067/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Endocannabinoid control of food intake and energy balance.</a></p> <p> </p> </div> </div></div></div></div> </div> </div> </div></div></div></div><div id="vc_row_1576086429975-5211063e-5166" class="vc_row wpb_row vc_row-fluid row-background-none"><div class="wpb_column vc_column_container vc_col-sm-6 row-background-none" id="vc_col_1576086429977-2555e0c1-ad63"><div class="vc_column-inner vc_custom_1576086786594"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element" > <div class="wpb_wrapper"> <div class="bkbm-grid bkbm-grid-pad bwl-kb bwl-row-cols-2"><div class="bkbcol-1-1"><h2 class="bwl-kb-category-title"><a href="https://cannaffex.ca/bwl-knowledge-base/bwl-knowledge-base-category/c/" title="C" data-wpel-link="internal"><i class="fa fa-file-o"></i> C</a></h2><div class="smk_accordion acc_with_icon" id="bkb_accordion_4198607066"><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Cancer</h4></div> <div class="acc_content" style="display: none;"><p><strong>Disease Markers 2020 Abstract: </strong><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746447/" data-wpel-link="external" rel="nofollow external noopener noreferrer">TRPV2: A Cancer Biomarker and Potential Therapeutic Target</a></p> <p><strong>NCBI 2019 Abstract: </strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387667/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabinoids in cancer treatment: Therapeutic potential and legislation</a></p> <p><strong>Springer link 2017 Article:</strong> <a href="https://link.springer.com/article/10.1007/s00280-017-3387-5" data-wpel-link="external" rel="nofollow external noopener noreferrer">A review of oral cannabinoids and medical marijuana for the treatment of chemotherapy-induced nausea and vomiting</a></p> <p><strong>NCBI 2013 Abstract:</strong><a href="https://pubmed.ncbi.nlm.nih.gov/22506672/" data-wpel-link="external" rel="nofollow external noopener noreferrer"> Cannabidiol as potential anticancer drug.</a></p> <p><strong>NCBI 2013 Abstract:</strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770515/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Critical appraisal of the potential use of cannabinoids in cancer management</a></p> <p><strong>Oncotarget 2014 Article:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/25115386/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabinoids as therapeutic agents in cancer: current status and future implications</a></p> <p><strong>NCBI 2011 Abstract:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/21475304/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy.</a></p> <p><strong>American Association of Cancer Research 2008 Abstract:</strong> <a href="https://aacrjournals.org/cancerres/article/68/2/339/541198/Cannabinoids-for-Cancer-Treatment-Progress-and" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabinoids for Cancer Treatment: Progress and Promise</a></p> <p><strong>Europe PMC 2007 Abstract:</strong> <a href="https://europepmc.org/article/med/17566383" data-wpel-link="external" rel="nofollow external noopener noreferrer"><span data-v-6bc9d8b5="">Cannabinoids in the treatment of chemotherapy-induced nausea and vomiting</span></a></p> <p><strong>American Association of Cancer Research 2006 Abstract: </strong><a href="https://aacrjournals.org/cancerres/article/66/13/6748/526025/Cannabinoids-Induce-Apoptosis-of-Pancreatic-Tumor" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabinoids Induce Apoptosis of Pancreatic Tumor Cells via Endoplasmic Reticulum Stress–Related Genes</a></p> <p><strong>FASEB Journal 2003 Abstract:</strong> <a href="https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fj.02-0795fje" data-wpel-link="external" rel="nofollow external noopener noreferrer">Inhibition of tumor angiogenesis by cannabinoids</a></p> <p><strong>NCBI 2003 Abstract:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/12511587/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors</a></p> <p> </p> <p> </p> <p> </p> </div> </div><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Cancer (Breast)</h4></div> <div class="acc_content" style="display: none;"><p><strong>International Journal of Molecular Sciences 2020 Study: </strong><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177247/" data-wpel-link="external" rel="nofollow external noopener noreferrer">CBD Reverts the Mesenchymal Invasive Phenotype of Breast Cancer Cells Induced by the Inflammatory Cytokine IL-1β</a></p> <p><strong>NCBI 2019 Study:</strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479799/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Future Aspects for Cannabinoids in Breast Cancer Therapy</a></p> <p><strong>Cancer Treatment Review 2012 Abstract:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/22776349/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabinoids: a new hope for breast cancer therapy?</a></p> <p><strong>Molecular Cancer Therapeutics 2011 Abstract:</strong> <a href="https://aacrjournals.org/mct/article/10/7/1161/91099/Cannabidiol-Induces-Programmed-Cell-Death-in" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk between Apoptosis and Autophagy</a></p> <p><strong>Molecular Cancer 2010 Abstract:</strong> <a href="https://molecular-cancer.biomedcentral.com/articles/10.1186/1476-4598-9-196" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition</a></p> <p><strong>NCBI 2007 Study: </strong><a href="https://pubmed.ncbi.nlm.nih.gov/18025276/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells.</a></p> <p> </p> </div> </div><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Cancer (Prostate)</h4></div> <div class="acc_content" style="display: none;"><p><strong>MarijuanaBreak 2019 Article: </strong> <a href="https://wayofleaf.com/cbd/ailments/cbd-for-prostate-cancer-exploring-the-facts" data-wpel-link="external" rel="nofollow external noopener noreferrer">CBD for Prostate Cancer [Does it Work?]</a></p> <p><strong>Cancer Medicine 2018 Abstract:</strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852356/" data-wpel-link="external" rel="nofollow external noopener noreferrer">The current state and future perspectives of cannabinoids in cancer biology</a></p> <p><strong>NCBI 2015 Abstract:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/25606819/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Proapoptotic effect of endocannabinoids in prostate cancer cells.</a></p> <p><strong>NCBI 2013 Study:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/22849856/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Towards the use of non-psychoactive cannabinoids for prostate cancer.</a></p> <p><strong>NCBI 2013 Study: </strong><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570006/" data-wpel-link="external" rel="nofollow external noopener noreferrer"> Non-THC cannabinoids inhibit prostate carcinoma growth <em>in vitro</em> and <em>in vivo</em>: pro-apoptotic effects and underlying mechanisms</a></p> <p><strong>NCBI 2012 Study:</strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339795/" data-wpel-link="external" rel="nofollow external noopener noreferrer">The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applications</a></p> <p><strong>EAUN Article:</strong> <a href="https://nurses.uroweb.org/using-cannabis-in-prostate-cancer-patients/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Using cannabis in prostate cancer patients</a></p> <p> </p> <p> </p> </div> </div><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Cerebral Palsy</h4></div> <div class="acc_content" style="display: none;"><p><strong>Frontiers of Pharmacology 2019 Study: </strong><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775595/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabidiol Administration Prevents Hypoxia-Ischemia-Induced Hypomyelination in Newborn Rats</a></p> <p><strong>Journal of Child Neurology 2018 Article:</strong> <a href="https://journals.sagepub.com/doi/abs/10.1177/0883073818773028" data-wpel-link="external" rel="nofollow external noopener noreferrer">Medical Cannabis for Pediatric Moderate to Severe Complex Motor Disorders</a></p> <p><strong>Journal of Pain 2016 Study:</strong> <a href="https://www.jpain.org/article/S1526-5900(16)30072-4/fulltext" data-wpel-link="external" rel="nofollow external noopener noreferrer">An Exploratory Human Laboratory Experiment Evaluating Vaporized Cannabis in the Treatment of Neuropathic Pain From Spinal Cord Injury and Disease</a></p> <p><strong>Patient Education 2015 Article:</strong> <a href="https://www.medicaljane.com/2014/07/07/cannabis-classroom-cerebral-palsy-and-medical-marijuana/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Treating Cerebral Palsy Symptoms With Medical Marijuana</a></p> <p><strong>US National Library of Medicine 2015 Study:</strong> <a href="https://clinicaltrials.gov/ct2/show/NCT02470325" data-wpel-link="external" rel="nofollow external noopener noreferrer">The Effects of Cannabis on Dystonia and Spasticity on Pediatric Patients</a></p> <p><strong>NCBI 2011 Abstract:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/21273894/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Survey results of pain treatments in adults with cerebral palsy.</a></p> </div> </div><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Chemotherapy (effects of)</h4></div> <div class="acc_content" style="display: none;"><p><strong>Frontiers of Oncology 2018 Abstract:</strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928848/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Enhancing the Therapeutic Efficacy of Cancer Treatment With Cannabinoids</a></p> <p><strong>BMJ Open 2017 Study:</strong> <a href="https://bmjopen.bmj.com/content/8/9/e020745" data-wpel-link="external" rel="nofollow external noopener noreferrer">Oral cannabinoid-rich THC/CBD cannabis extract for secondary prevention of chemotherapy-induced nausea and vomiting</a></p> <p><strong>Intl. Journal of Oncology 2017 study:</strong> <a href="https://www.spandidos-publications.com/10.3892/ijo.2017.4022" data-wpel-link="external" rel="nofollow external noopener noreferrer">Anticancer effects of phytocannabinoids used with chemotherapy in leukaemia cells can be improved by altering the sequence of their administration</a></p> <p><strong>Current Oncology 2016 Abstract:</strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791148/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Integrating cannabis into clinical cancer care</a></p> <p><strong>Cambridge University Press 2001 Abstract:</strong> <a href="https://www.cambridge.org/core/journals/the-british-journal-of-psychiatry/article/therapeutic-aspects-of-cannabis-and-cannabinoids/A6F35FDD2868806FD91F0F215B24736C" data-wpel-link="external" rel="nofollow external noopener noreferrer">Therapeutic aspects of cannabis and cannabinoids</a></p> <p> </p> </div> </div><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Chronic Fatigue Syndrome</h4></div> <div class="acc_content" style="display: none;"><p><strong>VeryWell Health 2019 Article:</strong> <a href="https://www.verywellhealth.com/cbd-oil-chronic-fatigue-syndrome-4174558" data-wpel-link="external" rel="nofollow external noopener noreferrer">CBD Oil for Chronic Fatigue Syndrome</a></p> <p><strong>Project CBD 2019 Article:</strong> <a href="https://projectcbd.org/health/cannabis-chronic-fatigue-syndrome/" data-wpel-link="external" rel="nofollow external noopener noreferrer">CANNABIS AND CHRONIC FATIGUE SYNDROME</a></p> <p><strong>The Growth Op 2019 Article:</strong> <a href="https://www.thegrowthop.com/cannabis-health/can-cannabis-help-with-chronic-fatigue-syndrome" data-wpel-link="external" rel="nofollow external noopener noreferrer">Can cannabis help with chronic fatigue syndrome?</a></p> <p><strong>Health Rising 2018 Article:</strong> <a href="https://www.healthrising.org/blog/2018/11/25/pinetrees-chronic-fatigue-syndrome-m-e-cbd-oil-success-story/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Pinetree’s Chronic Fatigue Syndrome / M.E. CBD Oil Success Story</a></p> <p> </p> </div> </div><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Chronic Pain</h4></div> <div class="acc_content" style="display: none;"><p><strong>Sage Open 2020 Study: </strong><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016302/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Medical cannibus as an alternative for opioids for chronic pain: A case report</a></p> <p><strong>PAIN 2019 Study: </strong><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319597/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain</a></p> <p><strong>Postgraduate Medicine 2019 Study:</strong> <a href="https://www.tandfonline.com/doi/full/10.1080/00325481.2019.1685298" data-wpel-link="external" rel="nofollow external noopener noreferrer">Evaluation of the effects of CBD hemp extract on opioid use and quality of life indicators in chronic pain patients: a prospective cohort study</a></p> <p><strong>CNET 2019 Article:</strong> <a href="https://www.cnet.com/health/nutrition/cbd-for-pain-relief-what-the-science-says/" data-wpel-link="external" rel="nofollow external noopener noreferrer">CBD for pain relief: What the science says</a></p> <p><strong>Science News 2018 Article:</strong> <a href="https://www.sciencedaily.com/releases/2018/10/181024163625.htm" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabis pain relief without the ‘high’</a></p> <div class="l-main"> <div class="l-left-holder"> <div class="l-content" role="main"> <article class="node node--article node--promoted node--full node--article--full" role="article"> <div class="node__content"> <div class="field field--name-body field--type-text-with-summary field--label-hidden"> <div class="field__items"> <div class="field__item even"><strong>NCBI 2018 Abstract:</strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222489/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabinoid Delivery Systems for Pain and Inflammation Treatment</a></div> </div> </div> </div> </article> </div> </div> </div> <p><strong>Frontiers in Pharmacology 2018 Abstract: </strong><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277878/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabinoids and Pain: New Insights From Old Molecules</a></p> <p><strong>NCBI 2017 Review:</strong> <a href="https://www.ncbi.nlm.nih.gov/books/NBK476449/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Benefits and Harms of Cannabis in Chronic Pain or Post-traumatic Stress Disorder</a></p> <p><strong>NCBI 2008 Abstract:</strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2503660/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabinoids in the management of difficult to treat pain</a></p> <p> </p> </div> </div><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Colitis</h4></div> <div class="acc_content" style="display: none;"><p><strong>Cochrane Library 2018 Study:</strong> <a href="https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD012954.pub2/references" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabis for the treatment of ulcerative colitis</a></p> <p><strong>Oxford Academic 2018 study:</strong> <a href="https://academic.oup.com/ibdjournal/article/24/4/680/4944355" data-wpel-link="external" rel="nofollow external noopener noreferrer">The Use of Cannabinoids in Colitis: A Systematic Review and Meta-Analysis</a></p> <p><strong>NCBI 2016 Abstract:</strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193087/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Therapeutic Use of Cannabis in Inflammatory Bowel Disease</a></p> <p><strong>PLOS ONE 2010 Study:</strong> <a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0009453" data-wpel-link="external" rel="nofollow external noopener noreferrer">The Cannabinoid 1 Receptor (<i>CNR1</i>) 1359 G/A Polymorphism Modulates Susceptibility to Ulcerative Colitis and the Phenotype in Crohn’s Disease</a></p> <p><strong>NCBI 2009 Abstract:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/20117132/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabinoids and the gut: new developments and emerging concepts.</a></p> <p> </p> <p> </p> </div> </div><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>COVID-19</h4></div> <div class="acc_content" style="display: none;"><p><strong>Frontiers in Immunology 2022 Study: </strong><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8886108/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabidiol and Terpene Formulation Reducing SARS-CoV-2 Infectivity Tackling a Therapeutic Strategy</a></p> <p><strong>StudyFinds 2021 Article: </strong><a href="https://www.studyfinds.org/cbd-covid-19-prevent-lung-damage/" data-wpel-link="external" rel="nofollow external noopener noreferrer">CBD for COVID-19: Marijuana ingredient may prevent virus from causing lung damage</a></p> <p><strong>MDPI Life 2021 Publication: </strong><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065867/" data-wpel-link="external" rel="nofollow external noopener noreferrer">In Vitro Evaluation of the Activity of Terpenes and Cannabidiol against Human Coronavirus E229</a></p> <p><strong>Br J Pharmacol 2020 Abstract: </strong><a href="https://pubmed.ncbi.nlm.nih.gov/32519753/" data-wpel-link="external" rel="nofollow external noopener noreferrer">The potential of cannabidiol in the COVID-19 pandemic</a></p> <div class="bkb_container bkb_clearfix"> <div class="bkb_btn_container bkb_clearfix" 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By relaxing the body to a calm state, hemp (cannabis) may alleviate withdrawal experienced by many drug and or alcohol addicts. Users of alcohol and other prescription drugs are searching for that “relaxing” and “calming” sensation. CBD works to combat both stress and anxiety and makes the process of quitting drugs and alcohol a lot less difficult.</p> <p><strong>MDPI 2019 Abstract: </strong><a href="https://www.mdpi.com/1420-3049/24/14/2583" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabidiol Treatment Might Promote Resilience to Cocaine and Methamphetamine Use Disorders: A Review of Possible Mechanisms</a></p> <p><strong> Neuropsychopharmacolgy 2019 Abstract: </strong><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098033/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Unique treatment potential of cannabidiol for the prevention of relapse to drug use: preclinical proof of principle</a></p> <p><strong>Neurotherapuetics 2015 Study: </strong><a href="https://pubmed.ncbi.nlm.nih.gov/26269227/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Early Phase in the Development of Cannabidiol as a Treatment for Addiction: Opioid Relapse Takes Initial Center Stage.</a></p> <p><strong>NCBI 2015 study: </strong><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444130/pdf/sart-9-2015-033.pdf" data-wpel-link="external" rel="nofollow external noopener noreferrer"> Cannabidiol as an Intervention for Addictive Behaviors: A Systematic Review of the Evidence</a></p> <p><strong>Addiction Biology 2013 Study: </strong><a href="https://pubmed.ncbi.nlm.nih.gov/22862835/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabidiol inhibits the reward-facilitating effect of morphine: involvement of 5-HT1A receptors in the dorsal raphe nucleus.</a></p> <p><strong>NCBI 2005 Abstract:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/15878999/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Comparison of cannabidiol, antioxidants, and diuretics in reversing binge ethanol-induced neurotoxicity.</a></p> <p> </p> <p> </p> </div> </div><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Dementia</h4></div> <div class="acc_content" style="display: none;"><p><strong>Dementia Care Central 2019 Article: </strong><a href="https://www.dementiacarecentral.com/aboutdementia/treating/cbd/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Using CBD (Cannabidiol) to Treat the Symptoms of Alzheimer’s & Other Dementias</a></p> <p><strong>The Cannigma 2019 Article:</strong> <a href="https://cannigma.com/conditions/dementia/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Can Cannabis Help Dementia?</a></p> <p><strong>U.S. National Library of Medicine 2017 Study:</strong> <a href="https://clinicaltrials.gov/ct2/show/NCT03328676" data-wpel-link="external" rel="nofollow external noopener noreferrer"> The Effect of Cannabis on Dementia Related Agitation and Aggression</a></p> <p><strong>NCBI 2017 Abstract:</strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485913/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabinoids for the treatment of dementia</a></p> <p><strong>NCBI 2010 Article:</strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033945/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabinoids and Dementia: A Review of Clinical and Preclinical Data</a></p> <p><strong>ResearchGate 2009 Study:</strong> <a href="https://www.researchgate.net/publication/24281678_Cannabinoids_for_the_treatment_of_dementia" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabinoids for the treatment of dementia</a></p> <p> </p> </div> </div><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Depression</h4></div> <div class="acc_content" style="display: none;"><p><strong>NCBI 2020 Study: </strong>E<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277553/" data-wpel-link="external" rel="nofollow external noopener noreferrer">ffects of Chronic Cannabidiol Treatment in the Rat Chronic Unpredictable Mild Stress Model of Depression</a></p> <p><strong>NCBI 2018 Abstract:</strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313625/" data-wpel-link="external" rel="nofollow external noopener noreferrer">New Perspectives on the Use of Cannabis in the Treatment of Psychiatric Disorders</a></p> <p><strong>Project CBD 2018 Article:</strong> <a href="https://projectcbd.org/psychedelic/cbd-receptor/" data-wpel-link="external" rel="nofollow external noopener noreferrer">CBD & THE PSYCHEDELIC RECEPTOR</a></p> <p><strong>Neurosychobiology 2016 Study:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/27010632/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Prohedonic Effect of Cannabidiol in a Rat Model of Depression.</a></p> <p><strong>NCBI 2012 Abstract:</strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586901/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Effect of Cannabinoid Receptor Activation on Spreading Depression</a></p> <p><strong>NCBI 2010 Study:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/20002102/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT1A receptors.</a></p> <p><strong>NCBI 2009 Abstract:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/19732971/" data-wpel-link="external" rel="nofollow external noopener noreferrer">The therapeutic potential of the endocannabinoid system for the development of a novel class of antidepressants.</a></p> </div> </div><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Dermatomyositis</h4></div> <div class="acc_content" style="display: none;"><p><strong>NCBI 2019 Abstract: </strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429381/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabinoid Signaling in the Skin: Therapeutic Potential of the “C(ut)annabinoid” System</a></p> <p><strong>Dermatol Online 2018 Review:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/30142706/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabinoids in dermatology: a scoping review.</a></p> <p><strong>JAAD 2017 Abstract: </strong> <a href="https://www.jaad.org/article/S0190-9622(17)30308-0/fulltext" data-wpel-link="external" rel="nofollow external noopener noreferrer">The role of cannabinoids in dermatology</a></p> <p><strong>Europe PMC 2017 Abstract:</strong> <a href="https://europepmc.org/article/med/28873100" data-wpel-link="external" rel="nofollow external noopener noreferrer"><span data-v-6bc9d8b5="">Topical cannabinoids in dermatology.</span></a></p> <p><strong>NCBI 2017 Article:</strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651184/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabinoid reduces inflammatory cytokines tumor necrosis factor alpha and type I interferons in dermatomyositis <em>in vitro</em></a></p> </div> </div><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Diabetes</h4></div> <div class="acc_content" style="display: none;"><p><strong>Healthline 2019 Article:</strong> <a href="https://www.healthline.com/health/cbd-for-diabetes" data-wpel-link="external" rel="nofollow external noopener noreferrer">Can CBD Oil Be Used to Treat or Prevent Diabetes? What the Research Says</a></p> <p><strong>Project CBD 2017 Article:</strong> <a href="https://projectcbd.org/health/cbd-as-preventative-medicine/" data-wpel-link="external" rel="nofollow external noopener noreferrer"> CBD AS PREVENTATIVE MEDICINE</a></p> <p><strong>American Diabetes 2016 Study:</strong> <a href="https://diabetesjournals.org/care/article/39/10/1777/129/Efficacy-and-Safety-of-Cannabidiol-and" data-wpel-link="external" rel="nofollow external noopener noreferrer">Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes</a></p> <p><strong>NCBI 2012 Abstract:</strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349875/" data-wpel-link="external" rel="nofollow external noopener noreferrer">The Endocannabinoid System and Plant-Derived Cannabinoids in Diabetes and Diabetic Complications</a></p> <p><strong>NCBI 2010 Abstract:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/21144973/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy.</a></p> <p><strong>ResearchGate 2010 Abstract:</strong> <a href="https://www.researchgate.net/publication/254088142_The_Role_of_Cannabis_and_Cannabinoids_in_Diabetes" data-wpel-link="external" rel="nofollow external noopener noreferrer">The role of cannabis and cannabinoids in diabetes</a></p> </div> </div></div></div></div> </div> </div> </div></div></div></div><div id="vc_row_1576087883643-bf9590fa-f267" class="vc_row wpb_row vc_row-fluid row-background-none"><div class="wpb_column vc_column_container vc_col-sm-6 row-background-none" id="vc_col_1576087883645-8e7c79e0-1851"><div class="vc_column-inner vc_custom_1576089142603"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element" > <div class="wpb_wrapper"> <p><span style="color: #000000;"><div class="bkbm-grid bkbm-grid-pad bwl-kb bwl-row-cols-2"><div class="bkbcol-1-1"><h2 class="bwl-kb-category-title"><a href="https://cannaffex.ca/bwl-knowledge-base/bwl-knowledge-base-category/e/" title="E" data-wpel-link="internal"><i class="fa fa-file-o"></i> E</a></h2><div class="smk_accordion acc_with_icon" id="bkb_accordion_1117218723"><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Eczema</h4></div> <div class="acc_content" style="display: none;"><p><strong>NCBI 2019 Abstract:</strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429381/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabinoid Signaling in the Skin: Therapeutic Potential of the “C(ut)annabinoid” System</a></p> <p><strong>Everyday Health 2019 Article:</strong> <a href="https://www.everydayhealth.com/skin-beauty/cbd-skin-care-are-these-products-worth-hype/" data-wpel-link="external" rel="nofollow external noopener noreferrer">What to Know About CBD Skin-Care Products</a></p> <p><strong>Science Daily 2017 Article:</strong> <a href="https://www.sciencedaily.com/releases/2017/04/170418094315.htm" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabinoids may soothe certain skin diseases, say researchers</a></p> <p><strong>NCBI 2007 Abstract:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/17157480/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis.</a></p> <div class="bkb_container bkb_clearfix"> <div class="bkb_btn_container bkb_clearfix" id="bkb_btn_container_55805737"> <div class="btn_like" title="Like The Post" vote_status="1" post_id="15753" bkb_unique_id="55805737"><i class="fa fa-thumbs-o-up bkb_icon_like_color"></i></div> <div class="btn_dislike" title="Dislike The Post" vote_status="0" post_id="15753" bkb_unique_id="55805737"><i class="fa fa-thumbs-o-down bkb_icon_dislike_color"></i></div> </div> <div class="stat-cnt" id="stat-cnt-55805737"> <div class="total-vote-counter">Total <span>0</span> Votes</div> <div class="stat-bar"> <div class="bg-green like_percentage" style="width:0%;"></div> <div class="bg-red dislike_percentage" style="width:0%;"></div> </div> <div class="count-container"><div class="like-count-container"><i class="fa fa-thumbs-o-up bkb_icon_like_color"></i> <span>0</span></div><div class="dislike-count-container"><i class="fa fa-thumbs-o-down bkb_icon_dislike_color"></i> <span>0</span></div></div> </div> </div> <div class="bkb-feedback-form-container" id="bkb_feedback_form_55805737"> <h2> Tell us how can we improve this post? </h2> <div class="bkb_feedback_form_error_box"></div> <form id="bkb_feedback_form" class="bkb_feedback_form" name="bkb_feedback_form" method="post" action="#"> <p> <textarea id="feedback_message" class="feedback_message_box" placeholder="Write feedback message ..... 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value="36d2e22272" /><input type="hidden" name="_wp_http_referer" value="/cbd-studies-and-reviews/" /> </form> </div> </div> </div><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Endometriosis</h4></div> <div class="acc_content" style="display: none;"><p><strong>E-Life 2019 Abstract:</strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977967/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Disease-modifying effects of natural Δ9-tetrahydrocannabinol in endometriosis-associated pain</a></p> <p><strong>Science Direct 2017 Abstract: </strong><a href="https://www.sciencedirect.com/science/article/abs/pii/S0006899317301245" data-wpel-link="external" rel="nofollow external noopener noreferrer"><span class="title-text">Cannabinoid receptor 1 contributes to sprouted innervation in endometrial ectopic growth through mitogen-activated protein kinase activation</span></a></p> <p><strong>Cannabas and Cannabinoid research 2017 Study: </strong><a href="https://www.liebertpub.com/doi/full/10.1089/can.2016.0035" data-wpel-link="external" rel="nofollow external noopener noreferrer">The Clinical Significance of Endocannabinoids in Endometriosis Pain Management</a></p> <p><strong>British journal of Pharmacology 2011 Study:</strong> <a href="https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/j.1476-5381.2011.01497.x" data-wpel-link="external" rel="nofollow external noopener noreferrer">Δ<sup>9</sup>‐Tetrahydrocannabinol and <i>N</i>‐arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC‐1B cells</a></p> <p> </p> </div> </div><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Epilepsy</h4></div> <div class="acc_content" style="display: none;"><p><strong>Neuropsychiatric Treatment 2020 Study: </strong><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012327/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabinoids in the Treatment of Epilepsy: Current Status and Future Prospects</a></p> <p><strong>U.S. Dept. of Veterans Affairs 2020 Abstract: </strong><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023903/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Prospects of Cannabidiol for Easing Status Epilepticus-Induced Epileptogenesis and Related Comorbidities</a></p> <p><strong>NCBI 2019 Study: </strong><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514832/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Use of Cannabidiol in the Treatment of Epilepsy: Efficacy and Security in Clinical Trials</a></p> <p><strong>Frontiers in Neurology 2018 Abstract: </strong><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143823/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabidiol for Treatment of Childhood Epilepsy–A Cross-Sectional Survey</a></p> <p><strong>NCBI 2018 Abstract:</strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235654/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Epilepsy and Cannabis (CBD): A Literature Review</a></p> <p><strong>Sage Journals 2017 Abstract:</strong> <a href="https://journals.sagepub.com/doi/full/10.5698/1535-7597-14.5.250" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabidiol: Promise and Pitfalls: Cannabidiol: Promise and Pitfalls</a></p> <p><strong>NCBI 2017 Abstract:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/24854329/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabidiol: pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders.</a></p> <p><strong>NCBI 2016 Abstract:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/26724101/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial.</a></p> <p><strong>Science Direct 2014 Abstract: </strong><a href="https://bbiosci.com/wp-content/uploads/2019/10/CBD_Epilepsy_Mechanisms.pdf" data-wpel-link="external" rel="nofollow external noopener noreferrer">Epilepsy & Behavior</a></p> <p><strong>NCBI 2014 Abstract: </strong> <a href="https://pubmed.ncbi.nlm.nih.gov/25282526/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabis, cannabidiol, and epilepsy–from receptors to clinical response.</a></p> <p> </p> <p> </p> </div> </div></div></div></div></span></p> </div> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-6 row-background-none" id="vc_col_1576695451605-818149ae-c386"><div class="vc_column-inner vc_custom_1576891896506"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element" > <div class="wpb_wrapper"> <p><span style="color: #000000;"><div class="bkbm-grid bkbm-grid-pad bwl-kb bwl-row-cols-2"><div class="bkbcol-1-1"><h2 class="bwl-kb-category-title"><a href="https://cannaffex.ca/bwl-knowledge-base/bwl-knowledge-base-category/f/" title="F" data-wpel-link="internal"><i class="fa fa-file-o"></i> F</a></h2><div class="smk_accordion acc_with_icon" id="bkb_accordion_2264154469"><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Fibromyalgia</h4></div> <div class="acc_content" style="display: none;"><p><strong>Journal of Clinical Medicine 2019 Abstract:</strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616435/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Safety and Efficacy of Medical Cannabis in Fibromyalgia</a></p> <p><strong>Heathline 2019 Article:</strong> <a href="https://www.healthline.com/health/cbd-for-fibromyalgia" data-wpel-link="external" rel="nofollow external noopener noreferrer">CBD for Fibromyalgia</a></p> <p><strong>Medical News Today Article: </strong><a href="https://www.medicalnewstoday.com/articles/321501" data-wpel-link="external" rel="nofollow external noopener noreferrer">How can CBD help with fibromyalgia?</a></p> <p><strong>Study of Pain Journal 2019 Study:</strong> <a href="https://journals.lww.com/pain/Fulltext/2019/04000/An_experimental_randomized_study_on_the_analgesic.11.aspx" data-wpel-link="external" rel="nofollow external noopener noreferrer">An experimental randomized study on the analgesic effects of pharmaceutical-grade <span class="ej-keyword" data-value="cannabis">cannabis</span> in <span class="ej-keyword" data-value="chronic pain">chronic pain</span> patients with <span class="ej-keyword" data-value="fibromyalgia">fibromyalgia</span></a></p> <p><strong>ResearchGate 2016 Abstract:</strong> <a href="https://www.researchgate.net/publication/305421346_Cannabinoids_for_fibromyalgia" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabinoids for fibromyalgia</a></p> <p><strong>NCBI 2011 Abstract: </strong><a href="https://pubmed.ncbi.nlm.nih.gov/21533029/" data-wpel-link="external" 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Article:</strong> <a href="https://plantsbeforepills.com/cbd-oil-for-heart-disease-health-benefits-of-cbd/" data-wpel-link="external" rel="nofollow external noopener noreferrer">CBD Oil for Heart Disease – Health Benefits of CBD</a></p> <p><strong>Healthline 2019 Article:</strong> <a href="https://www.healthline.com/health/cbd-for-heart-disease" data-wpel-link="external" rel="nofollow external noopener noreferrer">CBD for Heart Disease: Benefits, Side Effects, and Treatment</a></p> <p><strong>JCI Insight 2017 Anstract: </strong><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470879/" data-wpel-link="external" rel="nofollow external noopener noreferrer">A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study</a></p> <p><strong>Molecular Medicine 2015 Abstract: </strong><a href="https://pubmed.ncbi.nlm.nih.gov/25569804/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabidiol Protects against Doxorubicin-Induced Cardiomyopathy by Modulating Mitochondrial Function and Biogenesis.</a></p> <p><strong>British Journal of Pharmacology 2013 study: </strong><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579247/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Is the cardiovascular system a therapeutic target for cannabidiol?</a></p> <p><strong>BMJ Journals 2011 discussion: </strong><a href="https://heart.bmj.com/content/97/24/e8.9.abstract?cited-by=yes&legid=heartjnl%3B97/24/e8-q" data-wpel-link="external" rel="nofollow external noopener noreferrer">17 Cannabidiol as an anti-arrhythmic, the role of the CB1 receptors</a></p> <p><strong>NCBI 2010 Study:</strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026637/" data-wpel-link="external" rel="nofollow external noopener noreferrer"> Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, inflammatory and cell death signaling pathways in diabetic cardiomyopathy</a></p> <p> </p> <p> </p> </div> </div><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Huntington’s Disease</h4></div> <div class="acc_content" style="display: none;"><p><strong>CND Neurological disorder drug Targets 2017 Study: </strong><a href="https://pubmed.ncbi.nlm.nih.gov/28412918/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Neurological Aspects of Medical Use of Cannabidiol.</a></p> <p><strong>Neurotherapeutics 2015 Abstract:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/25252936/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Neuroprotective properties of cannabigerol in Huntington’s disease: studies in R6/2 mice and 3-nitropropionate-lesioned mice.</a></p> <p><strong>NCBI 2012 Abstract: </strong>Cannabinoids: <a href="https://pubmed.ncbi.nlm.nih.gov/22280340/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Novel medicines for the treatment of Huntington’s disease.</a></p> <p><strong>ACS Chem Neuroscience 2012 Study:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/22860209/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Sativex-like combination of phytocannabinoids is neuroprotective in malonate-lesioned rats, an inflammatory model of Huntington’s disease: role of CB1 and CB2 receptors.</a></p> <p><strong>NCBI 2011 Abstract:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/21674569/" data-wpel-link="external" rel="nofollow external noopener noreferrer"> Neuroprotective effects of phytocannabinoid-based medicines in experimental models of Huntington’s disease.</a></p> <p><strong>NCBI 2011 Abstract:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/21545415/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Prospects for cannabinoid therapies in basal ganglia disorders.</a></p> <p><strong>NCBI 2007 Abst</strong><strong>ract:</strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202504/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabinoids in health and disease</a></p> <div class="bkb_container bkb_clearfix"> <div class="bkb_btn_container bkb_clearfix" id="bkb_btn_container_1254662772"> <div class="btn_like" title="Like The Post" vote_status="1" post_id="15785" bkb_unique_id="1254662772"><i class="fa fa-thumbs-o-up bkb_icon_like_color"></i></div> <div class="btn_dislike" title="Dislike The Post" vote_status="0" post_id="15785" bkb_unique_id="1254662772"><i class="fa fa-thumbs-o-down bkb_icon_dislike_color"></i></div> </div> <div class="stat-cnt" id="stat-cnt-1254662772"> <div class="total-vote-counter">Total <span>0</span> Votes</div> <div class="stat-bar"> <div class="bg-green like_percentage" style="width:0%;"></div> <div class="bg-red dislike_percentage" style="width:0%;"></div> </div> <div class="count-container"><div class="like-count-container"><i class="fa fa-thumbs-o-up bkb_icon_like_color"></i> <span>0</span></div><div 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value="36d2e22272" /><input type="hidden" name="_wp_http_referer" value="/cbd-studies-and-reviews/" /> </form> </div> </div> </div><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Hypertension</h4></div> <div class="acc_content" style="display: none;"><p><strong>British Journal of Pharmacology 2018 Abstract: </strong><a href="https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.14168" rel="”nofollow” nofollow external noopener noreferrer" data-wpel-link="external">Cannabinoids in arterial, pulmonary and portal hypertension – mechanisms of action and potential therapeutic significance</a></p> <p><strong>Frontiers in Pharmacology 2017 Article:</strong> <a href="https://www.frontiersin.org/articles/10.3389/fphar.2017.00081/full" rel="”nofollow” nofollow external noopener noreferrer" data-wpel-link="external">A Systematic Review and Meta-Analysis of the Haemodynamic Effects of Cannabidiol</a></p> <p><strong>JCI Insight 2017 Abstract:</strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470879/" rel="”nofollow” nofollow external noopener noreferrer" data-wpel-link="external">A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study</a></p> <p><strong>NCBI 2013 Abstract: </strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579247/" rel="”nofollow” nofollow external noopener noreferrer" data-wpel-link="external">Is the cardiovascular system a therapeutic target for cannabidiol?</a></p> <p><strong>Journal of Pharmacology 1997 Study:</strong> <a href="https://jpet.aspetjournals.org/content/281/3/1030.short" rel="”nofollow” nofollow external noopener noreferrer" data-wpel-link="external">Cannabinoid-Induced Hypotension and Bradycardia in Rats Is Mediated by CB<sub>1</sub>-Like Cannabinoid Receptors</a></p> <p> </p> </div> </div></div></div></div> </div> </div> </div></div></div></div><div id="vc_row_1576086406403-d412d068-8ab4" class="vc_row wpb_row vc_row-fluid row-background-none"><div class="wpb_column vc_column_container vc_col-sm-6 row-background-none" id="vc_col_1576086406405-ecd32673-7c6c"><div class="vc_column-inner vc_custom_1576891712415"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element" > <div class="wpb_wrapper"> <div class="bkbm-grid bkbm-grid-pad bwl-kb bwl-row-cols-2"><div class="bkbcol-1-1"><h2 class="bwl-kb-category-title"><a href="https://cannaffex.ca/bwl-knowledge-base/bwl-knowledge-base-category/i/" title="I" data-wpel-link="internal"><i class="fa fa-file-o"></i> I</a></h2><div class="smk_accordion acc_with_icon" id="bkb_accordion_685248653"><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Impotence (Erectile Dysfunction)</h4></div> <div class="acc_content" style="display: none;"><p><strong>Weedmaps 2019 Article:</strong> <a href="https://weedmaps.com/learn/cbd/cbd-oil-erectile-dysfunction" data-wpel-link="external" rel="nofollow external noopener noreferrer">CBD OIL AND ERECTILE DYSFUNCTION</a></p> <p><strong>Healthline 2019 Article:</strong> <a href="https://www.healthline.com/health/healthy-sex/cbd-and-libido" data-wpel-link="external" rel="nofollow external noopener noreferrer">How Does CBD Affect Your Libido, and Does It Have a Place in Your Sex Life?</a></p> <p><strong>CBD80 2019 Article:</strong> <a href="https://www.cbdeighty.com/cbd-oil-and-erectile-dysfunction-everything-that-you-should-know/" data-wpel-link="external" rel="nofollow external noopener noreferrer">CBD OIL AND ERECTILE DYSFUNCTION – EVERYTHING THAT YOU SHOULD KNOW</a></p> <p><strong>Journal of Immunology Research 2013 Research:</strong> <a href="https://www.hindawi.com/journals/jir/2013/263846/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Treatment with CB<sub><b>2</b></sub> Agonist JWH-133 Reduces Histological Features Associated with Erectile Dysfunction in Hypercholesterolemic Mice</a></p> </div> </div><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Inflammatory Autoimmune Disease</h4></div> <div class="acc_content" style="display: none;"><p><strong>Frontiers in Immunology 2018 Abstract:</strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085417/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabidiol Attenuates Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis Through Induction of Myeloid-Derived Suppressor Cells</a></p> <p><strong>Frontiers in Immunology 2017 Abstract:</strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686045/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Targeting Cannabinoid Signaling in the Immune System: “High”-ly Exciting Questions, Possibilities, and Challenges</a></p> <p><strong>Experimental Neurology 2017 Abstract:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/28867485/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Mechanisms of action of cannabidiol in adoptively transferred experimental autoimmune encephalomyelitis.</a></p> <p><strong>NCBI 2016 Abstract: </strong> <a href="https://pubmed.ncbi.nlm.nih.gov/27435265/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabinoids, <span class="highlight">inflammation</span>, and fibrosis.</a></p> <p><strong>NCBI 2014 Abstract:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/?term=The%20endocannabinoid%20system%3A%20an%20emerging%20key%20player%20in%20inflammation" data-wpel-link="external" rel="nofollow external noopener noreferrer">The <span class="highlight">endocannabinoid</span> <span class="highlight">system</span>: an <span class="highlight">emerging</span> <span class="highlight">key</span> <span class="highlight">player</span> in <span class="highlight">inflammation</span>.</a></p> <p><strong>NCBI 2011 Abstract:</strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085542/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabidiol as an Emergent Therapeutic Strategy for Lessening the Impact of Inflammation on Oxidative Stress</a></p> <p><strong>PLOS ONE 2011 Abstract:</strong> <a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0028159" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabidiol Reduces Intestinal Inflammation through the Control of Neuroimmune Axis</a></p> <p><strong>NCBI 2010 Abstract: </strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828614/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabinoids as novel anti-inflammatory drugs</a></p> <p> </p> </div> </div><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Insomnia</h4></div> <div class="acc_content" style="display: none;"><p><strong>The Permanente Journal 2019 Study:</strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326553/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabidiol in Anxiety and Sleep: A Large Case Series</a></p> <p><strong>American Sleep Association 2019 Article: </strong> <a href="https://thesleepdoctor.com/cannabis-and-sleep/cbd-and-sleep/" data-wpel-link="external" rel="nofollow external noopener noreferrer">CBD: FOR SLEEP AND INSOMNIA</a></p> <p><strong>NCBI 2017 Abstract:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/28349316/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabis, Cannabinoids, and Sleep: a Review of the Literature.</a></p> <p>T<strong>he Sleep Doctor 2017 Article:</strong> <a href="https://thesleepdoctor.com/2017/08/10/understanding-cbd/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Understanding CBD: The calming and sleep promoting benefits of cannabidiol</a></p> <p><strong>NCBI 2014 Study:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/24520411/" data-wpel-link="external" rel="nofollow external noopener noreferrer"> Endocannabinoid modulation of cortical up-states and NREM sleep.</a></p> <p><strong>NCBI 2006 Study:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/16844117/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabidiol, a constituent of Cannabis sativa, modulates sleep in rats.</a></p> <p> </p> </div> </div><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Irritable Bowel Syndrome</h4></div> <div class="acc_content" style="display: none;"><p><strong>Biochemical Pharmacology 2018 Review:</strong> <a href="https://www.sciencedirect.com/science/article/abs/pii/S0006295218303186" data-wpel-link="external" rel="nofollow external noopener noreferrer"> <span class="title-text">Cannabinoid pharmacology and therapy in gut disorders</span></a></p> <p><strong>Medical Marijuana Article:</strong> <a href="https://www.medicalmarijuana.com/medical-marijuana-treatments-cannabis-uses/cannabinoids-cbdthc-treat-symptoms-of-ibs/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabinoids (CBD/THC) Treat Symptoms of IBS</a></p> <p><strong>NCBI 2017 Abstract: </strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388177/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabinoids for treating inflammatory bowel diseases: where are we and where do we go?</a></p> <p><strong>Gastroenterology and Hepatology 2016 Study: </strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193087/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Therapeutic Use of Cannabis in Inflammatory Bowel Disease</a></p> <p><strong>NCBI 2013 Overview: </strong> <a href="https://pubmed.ncbi.nlm.nih.gov/22815234/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabidiol in inflammatory bowel diseases: a brief overview.</a></p> <p><strong>NCBI 2011 Abstract:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/22163000/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabidiol reduces intestinal <span class="highlight">inflammation</span> through the control of neuroimmune axis.</a></p> <p><strong>Pharmacology Therapeutics 2010 Abstract: </strong> <a href="https://pubmed.ncbi.nlm.nih.gov/20117132/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabinoids and the gut: new developments and <span class="highlight">emerging</span> concepts.</a></p> <p> </p> </div> </div></div></div></div> </div> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-6 row-background-none" id="vc_col_1576088860988-1d038de5-1f1f"><div class="vc_column-inner vc_custom_1576891737086"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element" > <div class="wpb_wrapper"> <div class="bkbm-grid bkbm-grid-pad bwl-kb bwl-row-cols-2"><div class="bkbcol-1-1"><h2 class="bwl-kb-category-title"><a href="https://cannaffex.ca/bwl-knowledge-base/bwl-knowledge-base-category/l/" title="L" data-wpel-link="internal"><i class="fa fa-file-o"></i> L</a></h2><div class="smk_accordion acc_with_icon" id="bkb_accordion_2769245219"><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Leukemia</h4></div> <div class="acc_content" style="display: none;"><p> </p> <p><strong>International Journal of Molecular Sciences 2021 Study: <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7795267/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Phenolic Compounds Cannabidiol, Curcumin and Quercetin Cause Mitochondrial Dysfunction and Suppress Acute Lymphoblastic Leukemia Cells</a> </strong></p> <p><strong> Cell Death and Disease 2019 Study: </strong><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791884/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabidiol directly targets mitochondria and disturbs calcium homeostasis in acute lymphoblastic leukemia</a></p> <p><strong>Case Reports in Oncology 2013 Study: </strong><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901602/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabis Extract Treatment for Terminal Acute Lymphoblastic Leukemia with a Philadelphia Chromosome Mutation</a></p> </div> </div><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Lou Gehrig’s Disease (ALS)</h4></div> <div class="acc_content" style="display: none;"><p><strong>Norml 2019 Article: </strong><a href="https://norml.org/news/2019/01/17/study-thc-cbd-extract-associated-with-reduced-spasticity-in-als-patients" data-wpel-link="external" rel="nofollow external noopener noreferrer">Study: THC/CBD Extract Associated With Reduced Spasticity In ALS Patients</a></p> <p><strong>Journal of General Practice 2017 Study: </strong> <a href="https://hilarispublisher.com/open-access/comedication-with-cannabidiol-may-slow-down-the-progression-of-motorneuron-disease-a-case-report-2329-9126-1000316.pdf" data-wpel-link="external" rel="nofollow external noopener noreferrer">Co-medication with Cannabidiol May Slow Down the Progression of Motor Neuron Disease: A Case Report</a></p> <p><strong>NCBI 2010 Abstract: </strong> <a href="https://pubmed.ncbi.nlm.nih.gov/20439484/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabis and amyotrophic lateral sclerosis: hypothetical and practical applications, and a call for clinical trials.</a></p> </div> </div></div></div></div> </div> </div> </div></div></div></div><div id="vc_row_1576089288644-404bea8d-d6de" class="vc_row wpb_row vc_row-fluid row-background-none"><div class="wpb_column vc_column_container vc_col-sm-6 row-background-none" id="vc_col_1576089288647-062bdbdf-334d"><div class="vc_column-inner vc_custom_1576891931229"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element" > <div class="wpb_wrapper"> <div class="bkbm-grid bkbm-grid-pad bwl-kb bwl-row-cols-2"><div class="bkbcol-1-1"><h2 class="bwl-kb-category-title"><a href="https://cannaffex.ca/bwl-knowledge-base/bwl-knowledge-base-category/m/" title="m" data-wpel-link="internal"><i class="fa fa-file-o"></i> M</a></h2><div class="smk_accordion acc_with_icon" id="bkb_accordion_2042874248"><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Melanoma</h4></div> <div class="acc_content" style="display: none;"><p><strong>International Journal of Molecular Science 2020 Study: </strong><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503316/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Roles of Cannabinoids in Melanoma: Evidence from In Vivo Studies</a></p> <p><strong>Science Direct 2019 Study: </strong><a href="https://www.sciencedirect.com/science/article/abs/pii/S0022480418306267" data-wpel-link="external" rel="nofollow external noopener noreferrer"><span class="title-text">Cannabinoids as a Potential New and Novel Treatment for Melanoma: A Pilot Study in a Murine Model</span></a></p> <p><strong>Analytical Cannabis 2018 Article: </strong><a href="https://www.analyticalcannabis.com/articles/cannabinoids-shrink-tumors-in-new-study-311369" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabinoids Shrink Tumors in New Study</a></p> <p><strong>Cancer Medicine 2018 Study: </strong><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852356/" data-wpel-link="external" rel="nofollow external noopener noreferrer">The current state and future perspectives of cannabinoids in cancer biology</a></p> <p><strong>NCBI 2009 Study: </strong><a href="https://pubmed.ncbi.nlm.nih.gov/19608284/" data-wpel-link="external" rel="nofollow external noopener noreferrer">The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities.</a></p> <p><strong>NCBI 2003 Abstract:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/12511587/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors.</a></p> </div> </div><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Multiple Sclerosis (MS)</h4></div> <div class="acc_content" style="display: none;"><p><strong>Sage Journals 2019 Study: </strong><a href="https://journals.sagepub.com/doi/full/10.1177/1179573519831997" data-wpel-link="external" rel="nofollow external noopener noreferrer">Daily Practice Managing Resistant Multiple Sclerosis Spasticity With Delta-9-Tetrahydrocannabinol: Cannabidiol Oromucosal Spray</a></p> <p><strong>Multiple Sclerosis News Today 2019 Article: </strong><a href="https://multiplesclerosisnewstoday.com/2018/06/07/cannabinoids-use-multiple-sclerosis-experts-view/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Pharmacist Discusses Advances, Challenges in Cannabinoids Research to Treat MS</a></p> <p><strong>MS Society 2019 Article:</strong> <a href="https://www.mssociety.org.uk/research/latest-research/latest-research-news-and-blogs/cannabis-and-ms-research" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabis and MS research: what’s the evidence?</a></p> <p><strong>Chiropractic Economics 2019 Article:</strong> <a href="https://www.chiroeco.com/cbd-ms-patients/" data-wpel-link="external" rel="nofollow external noopener noreferrer">CBD for MS patients: a powerhouse duo for treating multiple sclerosis</a></p> <p><strong>Frontiers in Neurology 2018 Abstract:</strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874292/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabidiol to Improve Mobility in People with Multiple Sclerosis</a></p> <p><strong>Net Doctor 2018 Article: </strong><a href="https://www.netdoctor.co.uk/medicines/a26336640/cbd-oil-ms/" data-wpel-link="external" rel="nofollow external noopener noreferrer">CBD oil and MS: can cannabidiol alleviate multiple sclerosis symptoms?</a></p> <p><strong>Frontiers in Neurology 2017 Abstract: </strong><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481305/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabis and Multiple Sclerosis—The Way Forward</a></p> <p><strong>NCBI 2014 Study:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/24457846/" data-wpel-link="external" rel="nofollow external noopener noreferrer">THC:CBD spray and MS spasticity symptoms: data from latest studies.</a></p> <p><strong>Journal of Neurology 2005 Study:</strong> <a href="https://jnnp.bmj.com/content/76/12/1664" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabinoids in multiple sclerosis (CAMS) study: safety and efficacy data for 12 months follow up</a></p> <p> </p> </div> </div></div></div></div> </div> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-6 row-background-none" id="vc_col_1576089365646-d37a7813-49bd"><div class="vc_column-inner vc_custom_1576891938696"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element" > <div class="wpb_wrapper"> <div class="bkbm-grid bkbm-grid-pad bwl-kb bwl-row-cols-2"><div class="bkbcol-1-1"><h2 class="bwl-kb-category-title"><a href="https://cannaffex.ca/bwl-knowledge-base/bwl-knowledge-base-category/o/" title="o" data-wpel-link="internal"><i class="fa fa-file-o"></i> O</a></h2><div class="smk_accordion acc_with_icon" id="bkb_accordion_8638424"><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Obesity</h4></div> <div class="acc_content" style="display: none;"><p><strong>NCBI 2020 Study: </strong><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064444/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Phytocannabinoids: Useful Drugs for the Treatment of Obesity? Special Focus on Cannabidiol</a></p> <p><strong>NCBI 2018 Study: </strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163475/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Role of Cannabinoids in Obesity</a></p> <p><strong><span class="JournalTitle">Molecular and Cellular Biochemistry 2016 Abstract: </span></strong><a href="https://pubmed.ncbi.nlm.nih.gov/27067870/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabidiol promotes browning in 3T3-L1 adipocytes</a></p> <p><strong>Journal of Obesity 2016 study:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/25557382/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabis use in relation to obesity and insulin resistance in the Inuit population.</a></p> <p><b>Frontiers in Psychology 2014 Abstract: </b><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285050/#B24" data-wpel-link="external" rel="nofollow external noopener noreferrer">The endocannabinoid system: directing eating behavior and macronutrient metabolism</a></p> <p><strong>NCBI 2012 Study:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/22543671/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabinol and cannabidiol exert opposing effects on rat feeding patterns.</a></p> <p><strong>Diabetologia 2008 Abstract: </strong><a href="https://pubmed.ncbi.nlm.nih.gov/18563385/" data-wpel-link="external" rel="nofollow external noopener noreferrer">The endocannabinoid system in obesity and type 2 diabetes.</a></p> <p><strong>Dialogues In clinical Neuroscience 2017 Abstract:</strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202504/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabinoids in health and disease</a></p> </div> </div><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Obsessive Compulsive Disorder (OCD)</h4></div> <div class="acc_content" style="display: none;"><p><strong>Cannabis and Cannabinoid Research 2019 Abstract- </strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347041/" data-wpel-link="external" rel="nofollow external noopener noreferrer">The Endocannabinoid System: A New Treatment Target for Obsessive Compulsive Disorder?</a></p> </div> </div></div></div></div> </div> </div> </div></div></div></div><div id="vc_row_1576088855209-d67f460a-0635" class="vc_row wpb_row vc_row-fluid row-background-none"><div class="wpb_column vc_column_container vc_col-sm-6 row-background-none" id="vc_col_1576088855211-3c3a89d0-03b8"><div class="vc_column-inner vc_custom_1576891952197"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element" > <div class="wpb_wrapper"> <div class="bkbm-grid bkbm-grid-pad bwl-kb bwl-row-cols-2"><div class="bkbcol-1-1"><h2 class="bwl-kb-category-title"><a href="https://cannaffex.ca/bwl-knowledge-base/bwl-knowledge-base-category/p/" title="P" data-wpel-link="internal"><i class="fa fa-file-o"></i> P</a></h2><div class="smk_accordion acc_with_icon" id="bkb_accordion_2105455207"><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Parkinson’s Disease</h4></div> <div class="acc_content" style="display: none;"><p><strong>US National Library of Medicine 2019 Study: </strong><a href="https://clinicaltrials.gov/ct2/show/NCT02818777" rel="”noopener” nofollow external noopener noreferrer" data-wpel-link="external">A Study of Tolerability and Efficacy of Cannabidiol on Tremor in Parkinson’s Disease</a></p> <p><strong>NCBI 2017 Abstract:</strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436333/" rel="”noopener” nofollow external noopener noreferrer" data-wpel-link="external">Cannabinoids in Parkinson’s Disease</a></p> <p>Journal of Herbs, Spices & Medicinal Plants 2017 Abstract: <a href="https://www.tandfonline.com/doi/full/10.1080/10496475.2017.1312724" rel="”noopener” nofollow external noopener noreferrer" data-wpel-link="external">Cannabinoid Therapeutics in Parkinson’s Disease: Promise and Paradox</a></p> <p><strong>Journal of Psychopharmacology 2014 Study:</strong> <a href="https://www.researchgate.net/publication/265863783_Effects_of_cannabidiol_in_the_treatment_of_patients_with_Parkinson's_disease_An_exploratory_double-blind_trial" rel="”noopener” nofollow external noopener noreferrer" data-wpel-link="external">Effects of cannabidiol in the treatment of patients with Parkinson’s disease: An exploratory double-blind trial</a></p> <p><strong>NCBI 2014 Study: </strong> <a href="https://pubmed.ncbi.nlm.nih.gov/24614667/" rel="”noopener” nofollow external noopener noreferrer" data-wpel-link="external">Cannabis (medical marijuana) treatment for motor and non-motor symptoms of Parkinson disease: an open-label observational study.</a></p> </div> </div><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Post-Traumatic Stress Disorder (PTSD)</h4></div> <div class="acc_content" style="display: none;"><p class="journal-title"><strong>Journal of Dual Diagnosis 2019 Study: </strong><a href="https://pubmed.ncbi.nlm.nih.gov/31479625/" rel="”nofollow” nofollow external noopener noreferrer" data-wpel-link="external">The Effectiveness of Cannabinoids in the Treatment of Posttraumatic Stress Disorder (PTSD): A Systematic Review.</a></p> <p class="journal-title"><strong>The Journal of Alternative and Complementary Medicine 2019 Study:</strong> <a href="https://www.liebertpub.com/doi/full/10.1089/acm.2018.0437" rel="”nofollow” nofollow external noopener noreferrer" data-wpel-link="external">Cannabidiol in the Treatment of Post-Traumatic Stress Disorder: A Case Series</a></p> <p><strong>Nutritional Outlook 2019 Article:</strong> <a href="https://www.nutritionaloutlook.com/view/cbd-may-reduce-symptoms-ptsd-says-recently-published-study" rel="”nofollow” nofollow external noopener noreferrer" data-wpel-link="external">CBD may reduce symptoms of PTSD, says a recently published study</a></p> <section class="block block-dfp show-for-tablet-up block-dfp-welcome"> <div id="dfp-ad-welcome-wrapper" class="dfp-tag-wrapper"><strong>Frontiers in Neuroscience 2018 Study:</strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066583/" rel="”nofollow” nofollow external noopener noreferrer" data-wpel-link="external">Cannabidiol as a Therapeutic Alternative for Post-traumatic Stress Disorder: From Bench Research to Confirmation in Human Trials</a></div> </section> <p><strong>Behavioral Pharmacology 2018 study:</strong> <a href="https://www.ingentaconnect.com/content/wk/bepha/2016/00000027/00000007/art00001" rel="”nofollow” nofollow external noopener noreferrer" data-wpel-link="external">Cannabinoids and post-traumatic stress disorder: clinical and preclinical evidence for treatment and prevention</a></p> <p><strong>Maps Annual Report 2014 Article:</strong> <a href="https://maps.org/news-letters/v23n3/v23n3_40-42.pdf" rel="”nofollow” nofollow external noopener noreferrer" data-wpel-link="external">Cannabinoid Science Sheds New Light on the Darkness of PTSD</a></p> </div> </div><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Premenstrual Syndrome (PMS)</h4></div> <div class="acc_content" style="display: none;"><p><strong>DailyCBD 2019 Article: </strong> <a href="https://dailycbd.com/en/condition/premenstrual-syndrome/" data-wpel-link="external" rel="nofollow external noopener noreferrer">CBD & Premenstrual Syndrome: Current Research & Understanding</a></p> <p><strong>Medical News Today 2019 Article:</strong> <a href="https://www.medicalnewstoday.com/articles/322078" data-wpel-link="external" rel="nofollow external noopener noreferrer">Does CBD oil work for menopause symptoms?</a></p> <p><strong>NCBI 2011 Abstract: </strong> <a href="https://pubmed.ncbi.nlm.nih.gov/21175589/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Regulation of nausea and vomiting by cannabinoids</a></p> <p><strong>NCBI 2010 Study:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/21069097/" data-wpel-link="external" rel="nofollow external noopener noreferrer">The effects of Cannabis sativa L. seed (hempseed) in the ovariectomized rat model of menopause.</a></p> </div> </div><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Psoriasis</h4></div> <div class="acc_content" style="display: none;"><p><strong>Dermatology 2018 Article: </strong> <a href="https://www.practiceupdate.com/content/aad-2018-topical-cannabidiol-recommended-as-adjunct-treatment-for-acne-eczema-and-psoriasis/64728" data-wpel-link="external" rel="nofollow external noopener noreferrer">AAD 2018: Topical Cannabidiol Recommended as Adjunct Treatment for Acne, Eczema, and Psoriasis</a></p> <p><strong>Current Clinical Pharmacology 2016 Abstract:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/27164964/" data-wpel-link="external" rel="nofollow external noopener noreferrer"> Cannabis for Refractory Psoriasis-High Hopes for a Novel Treatment and a Literature Review.</a></p> <p><strong>Trends in Pharmacological Science 2009 Abstract:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/19608284/" data-wpel-link="external" rel="nofollow external noopener noreferrer">The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities.</a></p> <p><strong>Journal of Dermatological Science 2007 review:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/17157480/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis.</a></p> </div> </div></div></div></div> </div> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-6 row-background-none" id="vc_col_1576089580616-7904f351-adc4"><div class="vc_column-inner vc_custom_1576891960021"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element" > <div class="wpb_wrapper"> <div class="bkbm-grid bkbm-grid-pad bwl-kb bwl-row-cols-2"><div class="bkbcol-1-1"><h2 class="bwl-kb-category-title"><a href="https://cannaffex.ca/bwl-knowledge-base/bwl-knowledge-base-category/r/" title="R" data-wpel-link="internal"><i class="fa fa-file-o"></i> R</a></h2><div class="smk_accordion acc_with_icon" id="bkb_accordion_1729701642"><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Rheumatoid Arthritis</h4></div> <div class="acc_content" style="display: none;"><p><strong>NCBI 2019 Study: </strong><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561449/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Efficacy and safety of cannabidiol followed by an open label add-on of tetrahydrocannabinol for the treatment of chronic pain in patients with rheumatoid arthritis or ankylosing spondylitis: protocol for a multicentre, randomised, placebo-controlled study</a></p> <p><strong>Healthline 2018 Article:</strong> <a href="https://www.healthline.com/health/cbd-oil-for-rheumatoid-arthritis" data-wpel-link="external" rel="nofollow external noopener noreferrer">Can CBD Oil Treat Rheumatoid Arthritis Symptoms? </a></p> <p><strong>NCBI 2008 Study: </strong> <a href="https://pubmed.ncbi.nlm.nih.gov/18416822/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis.</a></p> <p><strong>Rheumatology 2006 Abstract: </strong> <a href="https://academic.oup.com/rheumatology/article/45/1/50/1788693" data-wpel-link="external" rel="nofollow external noopener noreferrer">Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis</a></p> <p><strong>PNAS 2000 Abstract:</strong> <a href="https://www.pnas.org/doi/full/10.1073/pnas.160105897" data-wpel-link="external" rel="nofollow external noopener noreferrer">The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis</a></p> </div> </div></div></div></div> </div> </div> </div></div></div></div><div id="vc_row_1576090987771-4371cf80-85a2" class="vc_row wpb_row vc_row-fluid row-background-none"><div class="wpb_column vc_column_container vc_col-sm-6 row-background-none" id="vc_col_1576090987773-a252322a-fc26"><div class="vc_column-inner vc_custom_1577460036610"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element" > <div class="wpb_wrapper"> <div class="bkbm-grid bkbm-grid-pad bwl-kb bwl-row-cols-2"><div class="bkbcol-1-1"><h2 class="bwl-kb-category-title"><a href="https://cannaffex.ca/bwl-knowledge-base/bwl-knowledge-base-category/s/" title="S" data-wpel-link="internal"><i class="fa fa-file-o"></i> S</a></h2><div class="smk_accordion acc_with_icon" id="bkb_accordion_402050286"><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Schizophrenia</h4></div> <div class="acc_content" style="display: none;"><p><strong>Science Direct 2017 Review: </strong><a href="https://www.sciencedirect.com/science/article/abs/pii/S0149763416307102" data-wpel-link="external" rel="nofollow external noopener noreferrer"><span class="title-text">Neuronal and molecular effects of cannabidiol on the mesolimbic dopamine system: Implications for novel schizophrenia treatments</span></a></p> <p><strong>Science Direct 2017 Abstract: </strong><a href="https://www.sciencedirect.com/science/article/abs/pii/S0149763416304390" data-wpel-link="external" rel="nofollow external noopener noreferrer"><span class="title-text">A systematic review of the effect of cannabidiol on cognitive function: Relevance to schizophrenia</span></a></p> <p><strong>Science Direct 2016 Abstract:</strong> <a href="https://www.sciencedirect.com/science/article/abs/pii/S0920996416302894" data-wpel-link="external" rel="nofollow external noopener noreferrer"><span class="title-text">Does cannabidiol have a role in the treatment of schizophrenia?</span></a></p> <p><b>NCBI 2016 Abstract: </b><a href="https://pubmed.ncbi.nlm.nih.gov/27267317/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Could cannabidiol be used as an alternative to antipsychotics?</a></p> <p><b>Neurotherapeutics 2015 Study:</b> <a href="https://link.springer.com/article/10.1007/s13311-015-0382-6" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabinoids and Schizophrenia: Risks and Therapeutic Potential</a></p> <p><strong>NCBI 2014 Abstract: </strong><a href="https://pubmed.ncbi.nlm.nih.gov/23829368/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabinoids and schizophrenia: therapeutic prospects.</a></p> <p><strong>Translational Psychiatry 2012 Abstract: </strong> <a href="https://www.nature.com/articles/tp201215" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia</a></p> <p><strong>NCBI 2009 Abstract:</strong> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168087/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabis and Schizophrenia Spectrum Disorders: A Review of Clinical Studies</a></p> </div> </div><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Seizures</h4></div> <div class="acc_content" style="display: none;"><p><strong>PNAS 2019 Article: </strong><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651774/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabidiol attenuates seizures and social deficits in a mouse model of Dravet syndrome</a></p> <p><strong>Science Daily 2019 Study: </strong><a href="https://www.sciencedaily.com/releases/2019/05/190521101450.htm" data-wpel-link="external" rel="nofollow external noopener noreferrer">CBD clinical trial results on seizure frequency in dogs ‘encouraging’</a></p> <p><strong>Epilepsy and Behaviour 2018 Abstract: </strong><a href="https://www.epilepsybehavior.com/article/S1525-5050(18)30473-6/fulltext" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabidiol improves frequency and severity of seizures and reduces adverse events in an open-label add-on prospective study</a></p> <p><strong>Frontiers in Neurology 2018 Analysis: </strong><a href="https://www.frontiersin.org/articles/10.3389/fneur.2018.00759/full?utm_source=FRN&utm_medium=EMAIL_IRIS&utm_campaign=EMI_FRN_ARTICLEPUBLISHED_FOLLOWERS&utm_content=ARTICLE_TITLE" data-wpel-link="external" rel="nofollow external noopener noreferrer">Potential Clinical Benefits of CBD-Rich <i>Cannabis</i> Extracts Over Purified CBD in Treatment-Resistant Epilepsy: Observational Data Meta-analysis</a></p> <p><strong>Science Daily 2018 Article:</strong> <a href="https://www.sciencedaily.com/releases/2018/05/180516172255.htm" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabidiol significantly reduces seizures in patients with severe form of epilepsy</a></p> <p><strong>Science Direct 2017 Study: </strong> <a href="https://www.sciencedirect.com/science/article/abs/pii/S088789941730053X" data-wpel-link="external" rel="nofollow external noopener noreferrer"><span class="title-text">Cannabidiol Treatment for Refractory Seizures in Sturge-Weber Syndrome</span></a></p> </div> </div><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Sleep Apnea</h4></div> <div class="acc_content" style="display: none;"><p><b>Medical News Today 2017 Article: </b><a href="https://www.medicalnewstoday.com/articles/320240#1" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabinoid drug found effective for treating sleep apnea</a></p> <p><b>Curr Psychiatry Report 2017 Abstract: </b><a href="https://www.med.upenn.edu/cbti/assets/user-content/documents/s11920-017-0775-9.pdf" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabis, Cannabinoids, and Sleep: a Review of the Literature</a></p> <p><strong>Project CBD 2017 Article:</strong> <a href="https://projectcbd.org/health/cannabis-sleep/" data-wpel-link="external" rel="nofollow external noopener noreferrer">CANNABIS & SLEEP DISTURBANCES</a></p> <p><strong>NCBI 2010 Study:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/21867717/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Effect of cannabidiol on sleep disruption induced by the repeated combination tests consisting of open field and elevated plus-maze in rats.</a></p> </div> </div><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Sleeping Disorders</h4></div> <div class="acc_content" style="display: none;"><p><strong>Consumer Reports 2019 Article: </strong><a href="https://www.consumerreports.org/cbd/can-cbd-help-you-sleep/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Can CBD Help You Sleep? Some research suggests it might be worth a try.</a></p> <p><strong>Sleep Disorders 2017 Abstract: </strong><a href="https://link.springer.com/article/10.1007/s11920-017-0775-9" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabis, Cannabinoids, and Sleep: a Review of the Literature</a></p> <p><strong>PlosOne 2016 Study: </strong><a href="https://pubmed.ncbi.nlm.nih.gov/27031992/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Endocannabinoid Signaling Regulates Sleep Stability.</a></p> <p><strong>Sleep Medicine Reviews 2014 Abstract: </strong><a href="https://pubmed.ncbi.nlm.nih.gov/24726015/" data-wpel-link="external" rel="nofollow external noopener noreferrer">The effects of cannabinoid administration on sleep: a systematic review of human studies.</a></p> <p><strong>Journal of Clinical Pharmacy and Therapeutics 2014 Report: </strong><a href="https://onlinelibrary.wiley.com/doi/abs/10.1111/jcpt.12179" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabidiol can improve complex sleep‐related behaviours associated with rapid eye movement sleep behaviour disorder in Parkinson’s disease patients.</a></p> <p><strong>Sage Journals 2013 Study: </strong> <a href="https://journals.sagepub.com/doi/abs/10.1177/0269881112474524" data-wpel-link="external" rel="nofollow external noopener noreferrer">Effects of acute systemic administration of cannabidiol on sleep-wake cycle in rats</a></p> <p><strong>NCBI 2006 Study:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/16844117/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabidiol, a constituent of Cannabis sativa, modulates sleep in rats.</a></p> </div> </div><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Spasticity</h4></div> <div class="acc_content" style="display: none;"><p><strong>Adis Drug Evaluation 2017 Review: </strong><a href="https://link.springer.com/article/10.1007/s40265-017-0720-6" data-wpel-link="external" rel="nofollow external noopener noreferrer">Delta-9-Tetrahydrocannabinol/Cannabidiol Oromucosal Spray (Sativex<sup>®</sup>): A Review in Multiple Sclerosis-Related Spasticity</a></p> <p><strong>Future Medicine 2016 Study: </strong><a href="https://www.futuremedicine.com/doi/abs/10.2217/nmt-2016-0047" data-wpel-link="external" rel="nofollow external noopener noreferrer">Evolution of multiple sclerosis spasticity-associated symptoms: latest data</a></p> <p><strong>Sage Journals 2015 Abstract: </strong><a href="https://journals.sagepub.com/doi/full/10.1177/1756285615612659" data-wpel-link="external" rel="nofollow external noopener noreferrer">Evidence for the efficacy and effectiveness of THC-CBD oromucosal spray in symptom management of patients with spasticity due to multiple sclerosis</a></p> <p><strong>BMC Neurology 2009 Abstract:</strong> <a href="https://bmcneurol.biomedcentral.com/articles/10.1186/1471-2377-9-59" data-wpel-link="external" rel="nofollow external noopener noreferrer">Whole plant cannabis extracts in the treatment of spasticity in multiple sclerosis: a systematic review</a></p> <p><strong>NCBI 2004 Study:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/15327040/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Efficacy, safety and tolerability of an orally administered cannabis extract in the treatment of spasticity in patients with multiple sclerosis: a randomized, double-blind, placebo-controlled, crossover study.</a></p> </div> </div></div></div></div> </div> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-6 row-background-none" id="vc_col_1576091005079-53a321d4-c72f"><div class="vc_column-inner vc_custom_1577460048484"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element" > <div class="wpb_wrapper"> <div class="bkbm-grid bkbm-grid-pad bwl-kb bwl-row-cols-2"><div class="bkbcol-1-1"><h2 class="bwl-kb-category-title"><a href="https://cannaffex.ca/bwl-knowledge-base/bwl-knowledge-base-category/t/" title="T" data-wpel-link="internal"><i class="fa fa-file-o"></i> T</a></h2><div class="smk_accordion acc_with_icon" id="bkb_accordion_2338108642"><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Tobacco Addiction</h4></div> <div class="acc_content" style="display: none;"><p><strong>Scientific Reports 2018 Abstract: </strong><a href="https://www.nature.com/articles/s41598-018-25846-2" data-wpel-link="external" rel="nofollow external noopener noreferrer">The effects of cannabidiol on impulsivity and memory during abstinence in cigarette dependent smokers</a></p> <p><strong>Fundacion Canna Article:</strong> <a href="https://www.fundacion-canna.es/en/cbd-treating-tobacco-addiction" data-wpel-link="external" rel="nofollow external noopener noreferrer">CBD for treating tobacco addiction?</a></p> <p><strong>NCBI 2018 Abstract: </strong><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099309/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabidiol reverses attentional bias to cigarette cues in a human experimental model of tobacco withdrawal</a></p> <p><strong>Neurotherapeutics 2015 Study: </strong><a href="https://pubmed.ncbi.nlm.nih.gov/26269227/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Early Phase in the Development of Cannabidiol as a Treatment for Addiction: Opioid Relapse Takes Initial Center Stage.</a></p> <p><strong>Sage Journals 2015 Review: </strong><a href="https://journals.sagepub.com/doi/full/10.4137/SART.S25081" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabidiol as an Intervention for Addictive Behaviors: A Systematic Review of the Evidence</a></p> <p><strong>Science Direct 2013 Study:</strong> <a href="https://www.sciencedirect.com/science/article/abs/pii/S030646031300083X" data-wpel-link="external" rel="nofollow external noopener noreferrer">C<span class="title-text">annabidiol reduces cigarette consumption in tobacco smo</span>kers: Preliminary findings.</a></p> </div> </div><div class="accordion_in"> <div class="acc_head"><div class="acc_icon_expand"></div><h4>Tourette Syndrome</h4></div> <div class="acc_content" style="display: none;"><p><strong>The International Journal of Psychiatry in Medicine 2018 Study: </strong><a href="https://journals.sagepub.com/doi/abs/10.1177/0091217418791455" data-wpel-link="external" rel="nofollow external noopener noreferrer">Pure delta-9-tetrahydrocannabinol and its combination with cannabidiol in treatment-resistant Tourette syndrome: A case report</a></p> <p><strong>Psychiatryonline.org 2017 Abstract: </strong><a href="https://neuro.psychiatryonline.org/doi/full/10.1176/appi.neuropsych.16110310" data-wpel-link="external" rel="nofollow external noopener noreferrer">Preliminary Evidence on Cannabis Effectiveness and Tolerability for Adults With Tourette Syndrome</a></p> <p><strong>NCBI 2017 Study: </strong><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447929/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Significant Tic Reduction in An Otherwise Treatment-Resistant Patient with Gilles de la Tourette Syndrome Following Treatment with Nabiximols</a></p> <p><strong>Behavioral Neurology 2013 Abstract:</strong> <a href="https://pubmed.ncbi.nlm.nih.gov/23187140/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Treatment of Tourette syndrome with cannabinoids.</a></p> <p><strong>NCBI 2008 Abstract: </strong> <a href="https://pubmed.ncbi.nlm.nih.gov/9879795/" data-wpel-link="external" rel="nofollow external noopener noreferrer">Cannabinoids: possible role in patho-physiology and therapy of Gilles de la Tourette syndrome.</a></p> </div> </div></div></div></div> </div> </div> </div></div></div></div><div id="vc_row_1577118221419-050e9863-b229" class="vc_row wpb_row vc_row-fluid row-background-none"><div class="wpb_column vc_column_container vc_col-sm-12 row-background-none" id="vc_col_1577118221422-6aa049e6-e1d6"><div class="vc_column-inner vc_custom_1577118937218"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element" > <div class="wpb_wrapper"> <p><strong>We will update weekly as the CBD Studies and Reviews come in…so check back often as the newest and most relevant CBD Studies and CBD reviews will be posted here.</strong></p> </div> </div> </div></div></div></div><div id="vc_row_1577119026541-5198a951-d811" class="vc_row wpb_row vc_row-fluid row-background-none"><div class="wpb_column vc_column_container vc_col-sm-12 row-background-none" id="vc_col_1577119026545-e7b7d864-a1d4"><div class="vc_column-inner "><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element vc_custom_1577460338844" > <div class="wpb_wrapper"> <hr /> <h5><span style="color: #76a731;">CURRENT RELATED ARTICLES:</span></h5> <p class="entry-title"><strong><a href="https://cannaffex.ca/cbd-multiple-sclerosis-ms/" rel="bookmark" data-wpel-link="internal">CBD for Multiple Sclerosis (MS) – All you need to know!</a><a href="https://cannaffex.ca/cbd-multiple-sclerosis-ms/" data-wpel-link="internal"> -2019</a></strong></p> <p class="entry-title"><strong><a href="https://cannaffex.ca/benefits-cbd-pain-inflammation/" rel="bookmark" data-wpel-link="internal">CBD for Pain & Inflammation -2019</a></strong></p> <p class="entry-title"><strong><a href="https://cannaffex.ca/cbd-treatment-for-add-adhd/" rel="bookmark" data-wpel-link="internal">CBD Treatment for ADD/ADHD -2019</a></strong></p> <p class="entry-title"><strong><a href="https://cannaffex.ca/benefits-of-cbd-for-stress-anxiety/" rel="bookmark" data-wpel-link="internal">CBD for Stress and Anxiety -2019</a></strong></p> <p class="entry-title"><strong><a href="https://cannaffex.ca/cbd-for-insomnia/" rel="bookmark" data-wpel-link="internal">CBD for Insomnia – Sleep Disorders -2019</a></strong></p> </div> </div> </div></div></div></div><div id="vc_row_1576091758346-51d44fa2-ff89" class="vc_row wpb_row vc_row-fluid row-background-none"><div class="wpb_column vc_column_container vc_col-sm-12 row-background-none" id="vc_col_1576091758350-5686c7d4-ab00"><div class="vc_column-inner "><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element" > <div class="wpb_wrapper"> <p> </p> <p><strong>*CBD has been shown to be effective in treating a vast range of ailments and their symptoms. CBD by no means is a “cure” for these diseases and ailments mentioned above, but these studies are to be referenced and used as a suggested resource to better understand the affects of CBD and the human body. The CBD studies and reviews show much promise for CBD, but do not substitute for the medical advice as given by your doctor. Always speak to your doctor first before trying CBD. You should be at least 18 years of age to use CBD products.</strong></p> </div> </div> <div class="ult-spacer spacer-67bef69da80e5" data-id="67bef69da80e5" data-height="100" data-height-mobile="100" data-height-tab="100" data-height-tab-portrait="" data-height-mobile-landscape="" style="clear:both;display:block;"></div></div></div></div></div></div> </div> </article> </main> </div> </div> <div class="sidebar col-sm-12 col-md-12 col-lg-4 col-xl-3 column"> <aside id="secondary" class="widget-area" role="complementary"> <div id="search-2" class="widget widget_search"><form role="search" method="get" id="searchform" class="clearfix" action="https://cannaffex.ca/" > <label class="screen-reader-text" for="s">Search for:</label> <input type="text" value="" name="s" id="s" placeholder="Search the Site…" /> <button class="search-button" value="Search" type="submit"> <i class="fa fa-search"></i> </button> </form> </div> <div id="recent-posts-2" class="widget widget_recent_entries"> <h4 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