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Safety Aspects in Treatment of Cancer by Carbamate Insectici | 433
<!DOCTYPE html> <html lang="es"> <head> <title>Safety Aspects in Treatment of Cancer by Carbamate Insectici | 433</title> <meta name="keywords" content="Mohammed Amanullah, Gaffar Sarwar Zaman and Naseem Begum, "/> <meta name="description" content="Cancer chemotherapy using carbamate insecticides has been published by the first author. This study was to evaluate their effects on other cell types becau..433"/> <meta name="citation_publisher" content="Ciencia y tecnolog铆a" /> <meta name="citation_journal_title" content="Revista de oncología clínica y experimental"> <meta name="citation_title" content="Safety Aspects in Treatment of Cancer by Carbamate Insecticides as Measured by Osmotic Fragility of Erythrocytes"> <meta name="citation_author" content="Mohammed Amanullah" /> <meta name="citation_author" content="Gaffar Sarwar Zaman" /> <meta name="citation_author" content="Naseem Begum" /> <meta name="citation_year" content=""> <meta name="citation_volume" content="2"> <meta name="citation_issue" content="1"> <meta name="citation_abstract" content="Cancer chemotherapy using carbamate insecticides has been published by the first author. This study was to evaluate their effects on other cell types because; pesticides and insecticides can affect the health of living organisms through different mechanisms such as membrane denaturation. The evaluation of the deleterious effects of chemical agents on biological membranes can be performed through the analysis of the stability of erythrocytes against a concentration gradient of certain chemical agent in physiologic saline solution. In the present study, technical grade carbamate insecticides viz., propoxur, carbaryl and carbofuran were tested for their toxicity on erythrocytes in vitro. Osmotic fragility of erythrocytes in different concentrations of saline, following exposure to technical grade carbamates was studied in order to indirectly assess the degree of anaemia and hypoxia, resulting upon exposure to carbamates. The percent hemolysis of sheep erythrocytes without carbamates (control), initiated at 0.45 percent NaCl solution, which reached 50% at 0.40 percent NaCl concentration. Complete hemolysis was seen at 0.35 percent NaCl.Baygon treated erythrocytes showed initial, 50% and complete hemolysis at 0.55, 0.45 and 0.35% NaCl respectively i.e. a little earlier as compared to the control. Carbaryl treated erythrocytes showed initial 50% and complete hemolysis at 0.65% NaCl, 0.55% and 0.45% concentration of NaCl respectively. Carbofuran exhibited less toxic effects on the fragility of erythrocytes as compared to baygon and carbaryl, where in the initial, 50% and complete haemolysis was seen at 0.50, 0.45 and 0.40 percent NaCl respectively. Though carbamate insecticides affected the integrity of the erythrocytes, the effect is transient and reversible and hence they can safely be used as chemotherapeutic agents for cancer."> <meta name="citation_abstract_html_url" content="https://spanish.scitechnol.com/abstract/safety-aspects-in-treatment-of-cancer-by-carbamate-insecticides-as-measured-by-osmotic-fragility-of-erythrocytes-433.html"> <meta itemprop="name" content="Ciencia y tecnolog铆a" /> <meta name="format-detection" content="telephone=no"> <meta http-equiv="Content-Language" content="es"> <meta name="google-site-verification" content="fht0Sbphb4JsUdVMASeyamGbjQ-E68ZABbBD_5ogQXY" /> <meta http-equiv="X-UA-Compatible" content="IE=edge"> <meta name="ROBOTS" content="INDEX,FOLLOW"> <meta name="googlebot" content="INDEX,FOLLOW"> <meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"> <link rel="canonical" 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This study was to evaluate their effects on other cell types because; pesticides and insecticides can affect the health of living organisms through different mechanisms such as membrane denaturation. The evaluation of the deleterious effects of chemical agents on biological membranes can be performed through the analysis of the stability of erythrocytes against a concentration gradient of certain chemical agent in physiologic saline solution. In the present study, technical grade carbamate insecticides viz., propoxur, carbaryl and carbofuran were tested for their toxicity on erythrocytes in vitro. Osmotic fragility of erythrocytes in different concentrations of saline, following exposure to technical grade carbamates was studied in order to indirectly assess the degree of anaemia and hypoxia, resulting upon exposure to carbamates. The percent hemolysis of sheep erythrocytes without carbamates (control), initiated at 0.45 percent NaCl solution, which reached 50% at 0.40 percent NaCl concentration. Complete hemolysis was seen at 0.35 percent NaCl.Baygon treated erythrocytes showed initial, 50% and complete hemolysis at 0.55, 0.45 and 0.35% NaCl respectively i.e. a little earlier as compared to the control. Carbaryl treated erythrocytes showed initial 50% and complete hemolysis at 0.65% NaCl, 0.55% and 0.45% concentration of NaCl respectively. Carbofuran exhibited less toxic effects on the fragility of erythrocytes as compared to baygon and carbaryl, where in the initial, 50% and complete haemolysis was seen at 0.50, 0.45 and 0.40 percent NaCl respectively. Though carbamate insecticides affected the integrity of the erythrocytes, the effect is transient and reversible and hence they can safely be used as chemotherapeutic agents for cancer.</p></p> <div class="alert alert-info text-left"><b>Descargo de responsabilidad:</b> este resumen se tradujo utilizando herramientas de inteligencia artificial y a煤n no ha sido revisado ni verificado.</div> </div> </div> <!-- sidebar --> <div class="col-xs-12 col-md-3"> <div class="divider-v4 divider-v4-left-double bg-color-white padding-10 margin-b-10"> <h2 class="divider-v4-title">Explorar SciTechnol</h2> <div> <ul class="list-unstyled angle-right"> <li class="color-base"><a href="https://spanish.scitechnol.com/author-guidelines.html" title="haga clic aqu铆"> Pautas para el autor</a></li> <li class="color-base"><a href="https://spanish.scitechnol.com/reviewer-guidelines.html" title="haga clic aqu铆"> Directrices para el revisor</a></li> <li class="color-base"><a 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