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<!DOCTYPE html> <html lang="en-US"> <head> <meta charset="UTF-8" /> <meta http-equiv="X-UA-Compatible" content="IE=edge"> <link rel="pingback" href="https://www.progeriaresearch.org/xmlrpc.php" /> <script type="text/javascript"> document.documentElement.className = 'js'; </script> <link rel="preconnect" href="https://fonts.gstatic.com" crossorigin /><style id="et-builder-googlefonts-cached-inline">/* Original: https://fonts.googleapis.com/css?family=Nunito+Sans:200,200italic,300,300italic,regular,italic,600,600italic,700,700italic,800,800italic,900,900italic|Lato:100,100italic,300,300italic,regular,italic,700,700italic,900,900italic&subset=latin,latin-ext&display=swap *//* User Agent: Mozilla/5.0 (Unknown; Linux x86_64) AppleWebKit/538.1 (KHTML, like Gecko) Safari/538.1 Daum/4.1 */@font-face {font-family: 'Lato';font-style: italic;font-weight: 100;font-display: swap;src: url(https://fonts.gstatic.com/s/lato/v24/S6u-w4BMUTPHjxsIPx-mPCc.ttf) format('truetype');}@font-face {font-family: 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et_pb_css_mix_blend_mode_passthrough et-last-child"> <div class="et_pb_row_inner et_pb_row_inner_0"> <div class="et_pb_column et_pb_column_4_4 et_pb_column_inner et_pb_column_inner_0 et-last-child"> <div class="et_pb_module et_pb_text et_pb_text_0 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><p><img decoding="async" class="size-full wp-image-1479 alignleft" src="https://www.progeriaresearch.org/wp-content/uploads/2017/04/lindsay-Jul08-crpd.jpg" alt="" width="193" height="164" />Hutchinson-Gilford Progeria Syndrome (“Progeria”, or “HGPS”) is a rare, fatal genetic condition characterized by an appearance of accelerated aging in children. Its name is derived from the Greek and means “prematurely old.” While there are different forms of Progeria*, the classic type is Hutchinson-Gilford Progeria Syndrome, which was named after the doctors who first described it in England; in 1886 by Dr. Jonathan Hutchinson and in 1897 by Dr. Hastings Gilford.</p> <p>HGPS is caused by a mutation in the gene called LMNA (pronounced, lamin – a). The LMNA gene produces the Lamin A protein, which is the structural scaffolding that holds the nucleus of a cell together. Researchers now believe that the defective Lamin A protein makes the nucleus unstable. That cellular instability appears to lead to the process of premature aging in Progeria.</p> <p>Although they are born looking healthy, children with Progeria begin to display many characteristics of accelerated aging within the first two years of life. Progeria signs include growth failure, loss of body fat and hair, aged-looking skin, stiffness of joints, hip dislocation, generalized atherosclerosis, cardiovascular (heart) disease and stroke. The children have a remarkably similar appearance, despite differing ethnic backgrounds. Without treatment, children with Progeria die of atherosclerosis (heart disease) at an average age of 14.5 years.</p> <p>* Other progeroid syndromes include Werner’s syndrome, also known as “adult progeria” which does not have an onset until the late teen years, with a life span into the 40’s and 50’s.</p></div> </div><div class="et_pb_button_module_wrapper et_pb_button_0_wrapper et_pb_module "> <a class="et_pb_button et_pb_button_0 et_pb_bg_layout_dark" href="https://www.progeriaresearch.org/scientific-publications/">View Scientific Publications</a> </div> </div> </div> </div> </div> </div><div class="et_pb_with_border et_pb_section et_pb_section_3 footer et_pb_with_background et_section_regular" > <div class="et_pb_row et_pb_row_0 et_pb_row_fullwidth et_pb_equal_columns"> <div class="et_pb_column et_pb_column_1_4 et_pb_column_2 et_pb_css_mix_blend_mode_passthrough"> <div class="et_pb_module et_pb_cta_0 sign-btn et_animated et_hover_enabled et_pb_promo et_pb_text_align_center 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