Search|Resources to understand how Alnylam鈥檚 RNAi-based medicines work

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By searching, you confirm that your query is unsolicited. </p><p>For more information about our FDA-approved therapies, please see the Full Prescribing Information:</p><ul><li><a class="no-speedbump" href="https://www.alnylam.com/sites/default/files/pdfs/amvuttra-us-prescribing-information.pdf" target="_blank">AMVUTTRA庐 (vutrisiran)</a></li><li><a class="no-speedbump" href="https://www.alnylam.com/sites/default/files/pdfs/GIVLAARI-Prescribing-Information.pdf" target="_blank">GIVLAARI庐 (givosiran)</a></li><li><a class="no-speedbump" href="https://www.alnylam.com/sites/default/files/pdfs/ONPATTRO-Prescribing-Information.pdf" target="_blank">ONPATTRO庐 (patisiran)</a></li><li><a class="no-speedbump" href="https://www.alnylam.com/sites/default/files/pdfs/OXLUMO-Prescribing-Information.pdf" target="_blank">OXLUMO庐 (lumasiran)</a></li></ul></div> </div> </div> </div> <div class="view-content results"> <div class="views-row"><div class="result"> <div class="title"> <h2> <a href="/sites/default/files/2024-03/DZSTATE_MA_ATTR%20symptoms%20and%20burden%20of%20disease_MED-US-DZSTATE-2400016.pdf" target="_blank"> Symptoms and Disease Burden of ATTR </a> <img src="/themes/custom/alnylam/assets/dist/images/document-icon.svg" alt="This link is a pdf" class="pdf-icon"> <div class="custom-media-bookmark-paragraph"> <div class="bookmarks no-auth force-auth"><a id="bookmark-login"><img src="/themes/custom/alnylam/assets/dist/images/bookmark.svg" class="desktop" alt="Bookmark this page"><img src="/themes/custom/alnylam/assets/dist/images/bookmark-mobile.svg" class="mobile" alt="Bookmark this page"></a></div> </div> <div class="custom-media-description-paragraph"> <div class="clearfix text-formatted field field--name-field-description field--type-text-long field--label-hidden field__item"><p>This slide deck provides an overview of the symptoms and disease burden of ATTR.</p></div> </div> </h2> </div> </div></div> <div class="views-row"><div class="result"> <div class="title"> <h2> <a href="/sites/default/files/2024-03/DZSTATE_MSL_V122I%20Deck_MED-US-DZSTATE-2300034.pdf" target="_blank"> Hereditary ATTR Amyloidosis: A Closer Look at the V122I Variant External </a> <img src="/themes/custom/alnylam/assets/dist/images/document-icon.svg" alt="This link is a pdf" class="pdf-icon"> <div class="custom-media-bookmark-paragraph"> <div class="bookmarks no-auth force-auth"><a id="bookmark-login"><img src="/themes/custom/alnylam/assets/dist/images/bookmark.svg" class="desktop" alt="Bookmark this page"><img src="/themes/custom/alnylam/assets/dist/images/bookmark-mobile.svg" class="mobile" alt="Bookmark this page"></a></div> </div> <div class="custom-media-description-paragraph"> <div class="clearfix text-formatted field field--name-field-description field--type-text-long field--label-hidden field__item"><p>V122I is the most common variant of hATTR amyloidosis in the United States and is most prevalent in patients of African American descent. Compared to other variants, patients with the V122I variant experience significant disease burden and poorer outcomes.</p></div> </div> </h2> </div> </div></div> <div class="views-row"><div class="result"> <div class="title"> <h2> <a href="/sites/default/files/2024-03/TTR02_MA_MSK%20Manifestations%20ATTR%20amyloidosis_MED-US-TTR02-2200101.pdf" target="_blank"> Musculoskeletal Manifestations Associated with ATTR Amyloidosis </a> <img src="/themes/custom/alnylam/assets/dist/images/document-icon.svg" alt="This link is a pdf" class="pdf-icon"> <div class="custom-media-bookmark-paragraph"> <div class="bookmarks no-auth force-auth"><a id="bookmark-login"><img src="/themes/custom/alnylam/assets/dist/images/bookmark.svg" class="desktop" alt="Bookmark this page"><img src="/themes/custom/alnylam/assets/dist/images/bookmark-mobile.svg" class="mobile" alt="Bookmark this page"></a></div> </div> <div class="custom-media-description-paragraph"> <div class="clearfix text-formatted field field--name-field-description field--type-text-long field--label-hidden field__item"><p>This slide deck provides disease education on ATTR amyloidosis, focusing on the musculoskeletal manifestations associated with the disease and their importance for early diagnosis and patient care.</p></div> </div> </h2> </div> </div></div> <div class="views-row"><div class="result"> <div class="title"> <h2> <a href="/sites/default/files/2024-07/DZSTATE_MA_ATTRv-PN-Expert-Opinion-Slide-Deck_MED-US-DZSTATE-2400005_0.pdf" target="_blank"> ATTRv-PN Expert Opinion Slide Deck </a> <img src="/themes/custom/alnylam/assets/dist/images/document-icon.svg" alt="This link is a pdf" class="pdf-icon"> <div class="custom-media-bookmark-paragraph"> <div class="bookmarks no-auth force-auth"><a id="bookmark-login"><img src="/themes/custom/alnylam/assets/dist/images/bookmark.svg" class="desktop" alt="Bookmark this page"><img src="/themes/custom/alnylam/assets/dist/images/bookmark-mobile.svg" class="mobile" alt="Bookmark this page"></a></div> </div> <div class="custom-media-description-paragraph"> <div class="clearfix text-formatted field field--name-field-description field--type-text-long field--label-hidden field__item"><p>Recommendations from a panel of experts for the diagnosis and treatment of hereditary transthyretin amyloidosis with polyneuropathy in the United States.</p></div> </div> </h2> </div> </div></div> <div class="views-row"><div class="result"> <div class="title"> <h2> <a href="/sites/default/files/2024-03/TTR02_MI_Hanna_AAHS_2024_MSK_MED-ALL-TTR02-2400002.pdf" target="_blank"> Musculoskeletal manifestations in patients with ATTR amyloidosis: Evidence from real-world analyses and clinical trials </a> <img src="/themes/custom/alnylam/assets/dist/images/document-icon.svg" alt="This link is a pdf" class="pdf-icon"> <div class="custom-media-bookmark-paragraph"> <div class="bookmarks no-auth force-auth"><a id="bookmark-login"><img src="/themes/custom/alnylam/assets/dist/images/bookmark.svg" class="desktop" alt="Bookmark this page"><img src="/themes/custom/alnylam/assets/dist/images/bookmark-mobile.svg" class="mobile" alt="Bookmark this page"></a></div> </div> <div class="custom-media-description-paragraph"> </div> </h2> </div> </div></div> </div> </div> </div> </div> </div> <div class="clearfix text-formatted field field--name-field-search-footer field--type-text-long field--label-hidden field__item"><p>For further information regarding your request, please <a href="/connect-with-us" data-entity-type="node" data-entity-uuid="14d16229-75d9-400d-b346-fa3db98f1e49" data-entity-substitution="canonical"><strong>connect with us</strong></a> by reaching out to your local Medical Science Liaison or contacting our Medical Information team.</p></div> </div> </div> </div> </div> </article> </div> </div> </div> <footer class="desktop-footer col-12 d-none d-xl-block" role="contentinfo"> <div class="block-content block-content--type-footer-content block-content--9 block-content--view-mode-full"> <div class="block-content__content"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>This site is intended for US healthcare professionals.<br>漏 2024 Alnylam Pharmaceuticals, Inc. 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