CINXE.COM

<!DOCTYPE html> <html lang="en-US" class="no-js"> <head> <meta charset="UTF-8"><script type="text/javascript">(window.NREUM||(NREUM={})).init={privacy:{cookies_enabled:true},ajax:{deny_list:["bam.eu01.nr-data.net"]},distributed_tracing:{enabled:true}};(window.NREUM||(NREUM={})).loader_config={agentID:"212354677",accountID:"3196970",trustKey:"3196970",xpid:"VwcOV19UCBACVVNRAgUCUlc=",licenseKey:"NRJS-0940f7eaf4cb46e1cfe",applicationID:"212354543"};;/*! For license information please see nr-loader-spa-1.274.0.min.js.LICENSE.txt */ (()=>{var e,t,r={8122:(e,t,r)=>{"use strict";r.d(t,{a:()=>i});var n=r(944);function i(e,t){try{if(!e||"object"!=typeof e)return(0,n.R)(3);if(!t||"object"!=typeof t)return(0,n.R)(4);const r=Object.create(Object.getPrototypeOf(t),Object.getOwnPropertyDescriptors(t)),o=0===Object.keys(r).length?e:r;for(let a in o)if(void 0!==e[a])try{if(null===e[a]){r[a]=null;continue}Array.isArray(e[a])&&Array.isArray(t[a])?r[a]=Array.from(new Set([...e[a],...t[a]])):"object"==typeof e[a]&&"object"==typeof t[a]?r[a]=i(e[a],t[a]):r[a]=e[a]}catch(e){(0,n.R)(1,e)}return r}catch(e){(0,n.R)(2,e)}}},2555:(e,t,r)=>{"use strict";r.d(t,{Vp:()=>c,fn:()=>s,x1:()=>u});var n=r(384),i=r(8122);const o={beacon:n.NT.beacon,errorBeacon:n.NT.errorBeacon,licenseKey:void 0,applicationID:void 0,sa:void 0,queueTime:void 0,applicationTime:void 0,ttGuid:void 0,user:void 0,account:void 0,product:void 0,extra:void 0,jsAttributes:{},userAttributes:void 0,atts:void 0,transactionName:void 0,tNamePlain:void 0},a={};function s(e){try{const t=c(e);return!!t.licenseKey&&!!t.errorBeacon&&!!t.applicationID}catch(e){return!1}}function c(e){if(!e)throw new Error("All info objects require an agent identifier!");if(!a[e])throw new Error("Info for ".concat(e," was never set"));return a[e]}function u(e,t){if(!e)throw new Error("All info objects require an agent identifier!");a[e]=(0,i.a)(t,o);const r=(0,n.nY)(e);r&&(r.info=a[e])}},9417:(e,t,r)=>{"use strict";r.d(t,{D0:()=>h,gD:()=>g,xN:()=>p});var n=r(993);const i=e=>{if(!e||"string"!=typeof e)return!1;try{document.createDocumentFragment().querySelector(e)}catch{return!1}return!0};var o=r(2614),a=r(944),s=r(384),c=r(8122);const u="[data-nr-mask]",d=()=>{const e={mask_selector:"*",block_selector:"[data-nr-block]",mask_input_options:{color:!1,date:!1,"datetime-local":!1,email:!1,month:!1,number:!1,range:!1,search:!1,tel:!1,text:!1,time:!1,url:!1,week:!1,textarea:!1,select:!1,password:!0}};return{ajax:{deny_list:void 0,block_internal:!0,enabled:!0,harvestTimeSeconds:10,autoStart:!0},distributed_tracing:{enabled:void 0,exclude_newrelic_header:void 0,cors_use_newrelic_header:void 0,cors_use_tracecontext_headers:void 0,allowed_origins:void 0},feature_flags:[],generic_events:{enabled:!0,harvestTimeSeconds:30,autoStart:!0},harvest:{tooManyRequestsDelay:60},jserrors:{enabled:!0,harvestTimeSeconds:10,autoStart:!0},logging:{enabled:!0,harvestTimeSeconds:10,autoStart:!0,level:n.p_.INFO},metrics:{enabled:!0,autoStart:!0},obfuscate:void 0,page_action:{enabled:!0},page_view_event:{enabled:!0,autoStart:!0},page_view_timing:{enabled:!0,harvestTimeSeconds:30,autoStart:!0},performance:{capture_marks:!1,capture_measures:!1},privacy:{cookies_enabled:!0},proxy:{assets:void 0,beacon:void 0},session:{expiresMs:o.wk,inactiveMs:o.BB},session_replay:{autoStart:!0,enabled:!1,harvestTimeSeconds:60,preload:!1,sampling_rate:10,error_sampling_rate:100,collect_fonts:!1,inline_images:!1,fix_stylesheets:!0,mask_all_inputs:!0,get mask_text_selector(){return e.mask_selector},set mask_text_selector(t){i(t)?e.mask_selector="".concat(t,",").concat(u):""===t||null===t?e.mask_selector=u:(0,a.R)(5,t)},get block_class(){return"nr-block"},get ignore_class(){return"nr-ignore"},get mask_text_class(){return"nr-mask"},get block_selector(){return e.block_selector},set block_selector(t){i(t)?e.block_selector+=",".concat(t):""!==t&&(0,a.R)(6,t)},get mask_input_options(){return e.mask_input_options},set mask_input_options(t){t&&"object"==typeof t?e.mask_input_options={...t,password:!0}:(0,a.R)(7,t)}},session_trace:{enabled:!0,harvestTimeSeconds:10,autoStart:!0},soft_navigations:{enabled:!0,harvestTimeSeconds:10,autoStart:!0},spa:{enabled:!0,harvestTimeSeconds:10,autoStart:!0},ssl:void 0,user_actions:{enabled:!0}}},l={},f="All configuration objects require an agent identifier!";function h(e){if(!e)throw new Error(f);if(!l[e])throw new Error("Configuration for ".concat(e," was never set"));return l[e]}function p(e,t){if(!e)throw new Error(f);l[e]=(0,c.a)(t,d());const r=(0,s.nY)(e);r&&(r.init=l[e])}function g(e,t){if(!e)throw new Error(f);var r=h(e);if(r){for(var n=t.split("."),i=0;i<n.length-1;i++)if("object"!=typeof(r=r[n[i]]))return;r=r[n[n.length-1]]}return r}},5603:(e,t,r)=>{"use strict";r.d(t,{a:()=>c,o:()=>s});var n=r(384),i=r(8122);const o={accountID:void 0,trustKey:void 0,agentID:void 0,licenseKey:void 0,applicationID:void 0,xpid:void 0},a={};function s(e){if(!e)throw new Error("All loader-config objects require an agent identifier!");if(!a[e])throw new Error("LoaderConfig for ".concat(e," was never set"));return a[e]}function c(e,t){if(!e)throw new Error("All loader-config objects require an agent identifier!");a[e]=(0,i.a)(t,o);const r=(0,n.nY)(e);r&&(r.loader_config=a[e])}},3371:(e,t,r)=>{"use strict";r.d(t,{V:()=>f,f:()=>l});var n=r(8122),i=r(384),o=r(6154),a=r(9324);let s=0;const c={buildEnv:a.F3,distMethod:a.Xs,version:a.xv,originTime:o.WN},u={customTransaction:void 0,disabled:!1,isolatedBacklog:!1,loaderType:void 0,maxBytes:3e4,onerror:void 0,ptid:void 0,releaseIds:{},appMetadata:{},session:void 0,denyList:void 0,timeKeeper:void 0,obfuscator:void 0},d={};function l(e){if(!e)throw new Error("All runtime objects require an agent identifier!");if(!d[e])throw new Error("Runtime for ".concat(e," was never set"));return d[e]}function f(e,t){if(!e)throw new Error("All runtime objects require an agent identifier!");d[e]={...(0,n.a)(t,u),...c},Object.hasOwnProperty.call(d[e],"harvestCount")||Object.defineProperty(d[e],"harvestCount",{get:()=>++s});const r=(0,i.nY)(e);r&&(r.runtime=d[e])}},9324:(e,t,r)=>{"use strict";r.d(t,{F3:()=>i,Xs:()=>o,Yq:()=>a,xv:()=>n});const n="1.274.0",i="PROD",o="CDN",a="^2.0.0-alpha.17"},6154:(e,t,r)=>{"use strict";r.d(t,{A4:()=>s,OF:()=>d,RI:()=>i,WN:()=>h,bv:()=>o,gm:()=>a,lR:()=>f,m:()=>u,mw:()=>c,sb:()=>l});var n=r(1863);const i="undefined"!=typeof window&&!!window.document,o="undefined"!=typeof WorkerGlobalScope&&("undefined"!=typeof self&&self instanceof WorkerGlobalScope&&self.navigator instanceof WorkerNavigator||"undefined"!=typeof globalThis&&globalThis instanceof WorkerGlobalScope&&globalThis.navigator instanceof WorkerNavigator),a=i?window:"undefined"!=typeof WorkerGlobalScope&&("undefined"!=typeof self&&self instanceof WorkerGlobalScope&&self||"undefined"!=typeof globalThis&&globalThis instanceof WorkerGlobalScope&&globalThis),s="complete"===a?.document?.readyState,c=Boolean("hidden"===a?.document?.visibilityState),u=""+a?.location,d=/iPad|iPhone|iPod/.test(a.navigator?.userAgent),l=d&&"undefined"==typeof SharedWorker,f=(()=>{const e=a.navigator?.userAgent?.match(/Firefox[/\s](\d+\.\d+)/);return Array.isArray(e)&&e.length>=2?+e[1]:0})(),h=Date.now()-(0,n.t)()},7295:(e,t,r)=>{"use strict";r.d(t,{Xv:()=>a,gX:()=>i,iW:()=>o});var n=[];function i(e){if(!e||o(e))return!1;if(0===n.length)return!0;for(var t=0;t<n.length;t++){var r=n[t];if("*"===r.hostname)return!1;if(s(r.hostname,e.hostname)&&c(r.pathname,e.pathname))return!1}return!0}function o(e){return void 0===e.hostname}function a(e){if(n=[],e&&e.length)for(var t=0;t<e.length;t++){let r=e[t];if(!r)continue;0===r.indexOf("http://")?r=r.substring(7):0===r.indexOf("https://")&&(r=r.substring(8));const i=r.indexOf("/");let o,a;i>0?(o=r.substring(0,i),a=r.substring(i)):(o=r,a="");let[s]=o.split(":");n.push({hostname:s,pathname:a})}}function s(e,t){return!(e.length>t.length)&&t.indexOf(e)===t.length-e.length}function c(e,t){return 0===e.indexOf("/")&&(e=e.substring(1)),0===t.indexOf("/")&&(t=t.substring(1)),""===e||e===t}},1687:(e,t,r)=>{"use strict";r.d(t,{Ak:()=>c,Ze:()=>l,x3:()=>u});var n=r(7836),i=r(3606),o=r(860),a=r(2646);const s={};function c(e,t){const r={staged:!1,priority:o.P3[t]||0};d(e),s[e].get(t)||s[e].set(t,r)}function u(e,t){e&&s[e]&&(s[e].get(t)&&s[e].delete(t),h(e,t,!1),s[e].size&&f(e))}function d(e){if(!e)throw new Error("agentIdentifier required");s[e]||(s[e]=new Map)}function l(e="",t="feature",r=!1){if(d(e),!e||!s[e].get(t)||r)return h(e,t);s[e].get(t).staged=!0,f(e)}function f(e){const t=Array.from(s[e]);t.every((([e,t])=>t.staged))&&(t.sort(((e,t)=>e[1].priority-t[1].priority)),t.forEach((([t])=>{s[e].delete(t),h(e,t)})))}function h(e,t,r=!0){const o=e?n.ee.get(e):n.ee,s=i.i.handlers;if(!o.aborted&&o.backlog&&s){if(r){const e=o.backlog[t],r=s[t];if(r){for(let t=0;e&&t<e.length;++t)p(e[t],r);Object.entries(r).forEach((([e,t])=>{Object.values(t||{}).forEach((t=>{t[0]?.on&&t[0]?.context()instanceof a.y&&t[0].on(e,t[1])}))}))}}o.isolatedBacklog||delete s[t],o.backlog[t]=null,o.emit("drain-"+t,[])}}function p(e,t){var r=e[1];Object.values(t[r]||{}).forEach((t=>{var r=e[0];if(t[0]===r){var n=t[1],i=e[3],o=e[2];n.apply(i,o)}}))}},7836:(e,t,r)=>{"use strict";r.d(t,{P:()=>c,ee:()=>u});var n=r(384),i=r(8990),o=r(3371),a=r(2646),s=r(5607);const c="nr@context:".concat(s.W),u=function e(t,r){var n={},s={},d={},l=!1;try{l=16===r.length&&(0,o.f)(r).isolatedBacklog}catch(e){}var f={on:p,addEventListener:p,removeEventListener:function(e,t){var r=n[e];if(!r)return;for(var i=0;i<r.length;i++)r[i]===t&&r.splice(i,1)},emit:function(e,r,n,i,o){!1!==o&&(o=!0);if(u.aborted&&!i)return;t&&o&&t.emit(e,r,n);for(var a=h(n),c=g(e),d=c.length,l=0;l<d;l++)c[l].apply(a,r);var p=v()[s[e]];p&&p.push([f,e,r,a]);return a},get:m,listeners:g,context:h,buffer:function(e,t){const r=v();if(t=t||"feature",f.aborted)return;Object.entries(e||{}).forEach((([e,n])=>{s[n]=t,t in r||(r[t]=[])}))},abort:function(){f._aborted=!0,Object.keys(f.backlog).forEach((e=>{delete f.backlog[e]}))},isBuffering:function(e){return!!v()[s[e]]},debugId:r,backlog:l?{}:t&&"object"==typeof t.backlog?t.backlog:{},isolatedBacklog:l};return Object.defineProperty(f,"aborted",{get:()=>{let e=f._aborted||!1;return e||(t&&(e=t.aborted),e)}}),f;function h(e){return e&&e instanceof a.y?e:e?(0,i.I)(e,c,(()=>new a.y(c))):new a.y(c)}function p(e,t){n[e]=g(e).concat(t)}function g(e){return n[e]||[]}function m(t){return d[t]=d[t]||e(f,t)}function v(){return f.backlog}}(void 0,"globalEE"),d=(0,n.Zm)();d.ee||(d.ee=u)},2646:(e,t,r)=>{"use strict";r.d(t,{y:()=>n});class n{constructor(e){this.contextId=e}}},9908:(e,t,r)=>{"use strict";r.d(t,{d:()=>n,p:()=>i});var n=r(7836).ee.get("handle");function i(e,t,r,i,o){o?(o.buffer([e],i),o.emit(e,t,r)):(n.buffer([e],i),n.emit(e,t,r))}},3606:(e,t,r)=>{"use strict";r.d(t,{i:()=>o});var n=r(9908);o.on=a;var i=o.handlers={};function o(e,t,r,o){a(o||n.d,i,e,t,r)}function a(e,t,r,i,o){o||(o="feature"),e||(e=n.d);var a=t[o]=t[o]||{};(a[r]=a[r]||[]).push([e,i])}},3878:(e,t,r)=>{"use strict";function n(e,t){return{capture:e,passive:!1,signal:t}}function i(e,t,r=!1,i){window.addEventListener(e,t,n(r,i))}function o(e,t,r=!1,i){document.addEventListener(e,t,n(r,i))}r.d(t,{DD:()=>o,jT:()=>n,sp:()=>i})},5607:(e,t,r)=>{"use strict";r.d(t,{W:()=>n});const n=(0,r(9566).bz)()},9566:(e,t,r)=>{"use strict";r.d(t,{LA:()=>s,ZF:()=>c,bz:()=>a,el:()=>u});var n=r(6154);const i="xxxxxxxx-xxxx-4xxx-yxxx-xxxxxxxxxxxx";function o(e,t){return e?15&e[t]:16*Math.random()|0}function a(){const e=n.gm?.crypto||n.gm?.msCrypto;let t,r=0;return e&&e.getRandomValues&&(t=e.getRandomValues(new Uint8Array(30))),i.split("").map((e=>"x"===e?o(t,r++).toString(16):"y"===e?(3&o()|8).toString(16):e)).join("")}function s(e){const t=n.gm?.crypto||n.gm?.msCrypto;let r,i=0;t&&t.getRandomValues&&(r=t.getRandomValues(new Uint8Array(e)));const a=[];for(var s=0;s<e;s++)a.push(o(r,i++).toString(16));return a.join("")}function c(){return s(16)}function u(){return s(32)}},2614:(e,t,r)=>{"use strict";r.d(t,{BB:()=>a,H3:()=>n,g:()=>u,iL:()=>c,tS:()=>s,uh:()=>i,wk:()=>o});const n="NRBA",i="SESSION",o=144e5,a=18e5,s={STARTED:"session-started",PAUSE:"session-pause",RESET:"session-reset",RESUME:"session-resume",UPDATE:"session-update"},c={SAME_TAB:"same-tab",CROSS_TAB:"cross-tab"},u={OFF:0,FULL:1,ERROR:2}},1863:(e,t,r)=>{"use strict";function n(){return Math.floor(performance.now())}r.d(t,{t:()=>n})},7485:(e,t,r)=>{"use strict";r.d(t,{D:()=>i});var n=r(6154);function i(e){if(0===(e||"").indexOf("data:"))return{protocol:"data"};try{const t=new URL(e,location.href),r={port:t.port,hostname:t.hostname,pathname:t.pathname,search:t.search,protocol:t.protocol.slice(0,t.protocol.indexOf(":")),sameOrigin:t.protocol===n.gm?.location?.protocol&&t.host===n.gm?.location?.host};return r.port&&""!==r.port||("http:"===t.protocol&&(r.port="80"),"https:"===t.protocol&&(r.port="443")),r.pathname&&""!==r.pathname?r.pathname.startsWith("/")||(r.pathname="/".concat(r.pathname)):r.pathname="/",r}catch(e){return{}}}},944:(e,t,r)=>{"use strict";function n(e,t){"function"==typeof console.debug&&console.debug("New Relic Warning: https://github.com/newrelic/newrelic-browser-agent/blob/main/docs/warning-codes.md#".concat(e),t)}r.d(t,{R:()=>n})},5284:(e,t,r)=>{"use strict";r.d(t,{t:()=>c,B:()=>s});var n=r(7836),i=r(6154);const o="newrelic";const a=new Set,s={};function c(e,t){const r=n.ee.get(t);s[t]??={},e&&"object"==typeof e&&(a.has(t)||(r.emit("rumresp",[e]),s[t]=e,a.add(t),function(e={}){try{i.gm.dispatchEvent(new CustomEvent(o,{detail:e}))}catch(e){}}({loaded:!0})))}},8990:(e,t,r)=>{"use strict";r.d(t,{I:()=>i});var n=Object.prototype.hasOwnProperty;function i(e,t,r){if(n.call(e,t))return e[t];var i=r();if(Object.defineProperty&&Object.keys)try{return Object.defineProperty(e,t,{value:i,writable:!0,enumerable:!1}),i}catch(e){}return e[t]=i,i}},6389:(e,t,r)=>{"use strict";function n(e,t=500,r={}){const n=r?.leading||!1;let i;return(...r)=>{n&&void 0===i&&(e.apply(this,r),i=setTimeout((()=>{i=clearTimeout(i)}),t)),n||(clearTimeout(i),i=setTimeout((()=>{e.apply(this,r)}),t))}}function i(e){let t=!1;return(...r)=>{t||(t=!0,e.apply(this,r))}}r.d(t,{J:()=>i,s:()=>n})},3304:(e,t,r)=>{"use strict";r.d(t,{A:()=>o});var n=r(7836);const i=()=>{const e=new WeakSet;return(t,r)=>{if("object"==typeof r&&null!==r){if(e.has(r))return;e.add(r)}return r}};function o(e){try{return JSON.stringify(e,i())??""}catch(e){try{n.ee.emit("internal-error",[e])}catch(e){}return""}}},5289:(e,t,r)=>{"use strict";r.d(t,{GG:()=>o,sB:()=>a});var n=r(3878);function i(){return"undefined"==typeof document||"complete"===document.readyState}function o(e,t){if(i())return e();(0,n.sp)("load",e,t)}function a(e){if(i())return e();(0,n.DD)("DOMContentLoaded",e)}},384:(e,t,r)=>{"use strict";r.d(t,{NT:()=>o,US:()=>d,Zm:()=>a,bQ:()=>c,dV:()=>s,nY:()=>u,pV:()=>l});var n=r(6154),i=r(1863);const o={beacon:"bam.nr-data.net",errorBeacon:"bam.nr-data.net"};function a(){return n.gm.NREUM||(n.gm.NREUM={}),void 0===n.gm.newrelic&&(n.gm.newrelic=n.gm.NREUM),n.gm.NREUM}function s(){let e=a();return e.o||(e.o={ST:n.gm.setTimeout,SI:n.gm.setImmediate,CT:n.gm.clearTimeout,XHR:n.gm.XMLHttpRequest,REQ:n.gm.Request,EV:n.gm.Event,PR:n.gm.Promise,MO:n.gm.MutationObserver,FETCH:n.gm.fetch,WS:n.gm.WebSocket}),e}function c(e,t){let r=a();r.initializedAgents??={},t.initializedAt={ms:(0,i.t)(),date:new Date},r.initializedAgents[e]=t}function u(e){let t=a();return t.initializedAgents?.[e]}function d(e,t){a()[e]=t}function l(){return function(){let e=a();const t=e.info||{};e.info={beacon:o.beacon,errorBeacon:o.errorBeacon,...t}}(),function(){let e=a();const t=e.init||{};e.init={...t}}(),s(),function(){let e=a();const t=e.loader_config||{};e.loader_config={...t}}(),a()}},2843:(e,t,r)=>{"use strict";r.d(t,{u:()=>i});var n=r(3878);function i(e,t=!1,r,i){(0,n.DD)("visibilitychange",(function(){if(t)return void("hidden"===document.visibilityState&&e());e(document.visibilityState)}),r,i)}},8139:(e,t,r)=>{"use strict";r.d(t,{u:()=>f});var n=r(7836),i=r(3434),o=r(8990),a=r(6154);const s={},c=a.gm.XMLHttpRequest,u="addEventListener",d="removeEventListener",l="nr@wrapped:".concat(n.P);function f(e){var t=function(e){return(e||n.ee).get("events")}(e);if(s[t.debugId]++)return t;s[t.debugId]=1;var r=(0,i.YM)(t,!0);function f(e){r.inPlace(e,[u,d],"-",p)}function p(e,t){return e[1]}return"getPrototypeOf"in Object&&(a.RI&&h(document,f),h(a.gm,f),h(c.prototype,f)),t.on(u+"-start",(function(e,t){var n=e[1];if(null!==n&&("function"==typeof n||"object"==typeof n)){var i=(0,o.I)(n,l,(function(){var e={object:function(){if("function"!=typeof n.handleEvent)return;return n.handleEvent.apply(n,arguments)},function:n}[typeof n];return e?r(e,"fn-",null,e.name||"anonymous"):n}));this.wrapped=e[1]=i}})),t.on(d+"-start",(function(e){e[1]=this.wrapped||e[1]})),t}function h(e,t,...r){let n=e;for(;"object"==typeof n&&!Object.prototype.hasOwnProperty.call(n,u);)n=Object.getPrototypeOf(n);n&&t(n,...r)}},3434:(e,t,r)=>{"use strict";r.d(t,{Jt:()=>o,YM:()=>c});var n=r(7836),i=r(5607);const o="nr@original:".concat(i.W);var a=Object.prototype.hasOwnProperty,s=!1;function c(e,t){return e||(e=n.ee),r.inPlace=function(e,t,n,i,o){n||(n="");const a="-"===n.charAt(0);for(let s=0;s<t.length;s++){const c=t[s],u=e[c];d(u)||(e[c]=r(u,a?c+n:n,i,c,o))}},r.flag=o,r;function r(t,r,n,s,c){return d(t)?t:(r||(r=""),nrWrapper[o]=t,function(e,t,r){if(Object.defineProperty&&Object.keys)try{return Object.keys(e).forEach((function(r){Object.defineProperty(t,r,{get:function(){return e[r]},set:function(t){return e[r]=t,t}})})),t}catch(e){u([e],r)}for(var n in e)a.call(e,n)&&(t[n]=e[n])}(t,nrWrapper,e),nrWrapper);function nrWrapper(){var o,a,d,l;try{a=this,o=[...arguments],d="function"==typeof n?n(o,a):n||{}}catch(t){u([t,"",[o,a,s],d],e)}i(r+"start",[o,a,s],d,c);try{return l=t.apply(a,o)}catch(e){throw i(r+"err",[o,a,e],d,c),e}finally{i(r+"end",[o,a,l],d,c)}}}function i(r,n,i,o){if(!s||t){var a=s;s=!0;try{e.emit(r,n,i,t,o)}catch(t){u([t,r,n,i],e)}s=a}}}function u(e,t){t||(t=n.ee);try{t.emit("internal-error",e)}catch(e){}}function d(e){return!(e&&"function"==typeof e&&e.apply&&!e[o])}},9300:(e,t,r)=>{"use strict";r.d(t,{T:()=>n});const n=r(860).K7.ajax},3333:(e,t,r)=>{"use strict";r.d(t,{TZ:()=>n,Zp:()=>i,mq:()=>s,nf:()=>a,qN:()=>o});const n=r(860).K7.genericEvents,i=["auxclick","click","copy","keydown","paste","scrollend"],o=["focus","blur"],a=4,s=1e3},6774:(e,t,r)=>{"use strict";r.d(t,{T:()=>n});const n=r(860).K7.jserrors},993:(e,t,r)=>{"use strict";r.d(t,{ET:()=>o,TZ:()=>a,p_:()=>i});var n=r(860);const i={ERROR:"ERROR",WARN:"WARN",INFO:"INFO",DEBUG:"DEBUG",TRACE:"TRACE"},o="log",a=n.K7.logging},3785:(e,t,r)=>{"use strict";r.d(t,{R:()=>c,b:()=>u});var n=r(9908),i=r(1863),o=r(860),a=r(3969),s=r(993);function c(e,t,r={},c=s.p_.INFO){(0,n.p)(a.xV,["API/logging/".concat(c.toLowerCase(),"/called")],void 0,o.K7.metrics,e),(0,n.p)(s.ET,[(0,i.t)(),t,r,c],void 0,o.K7.logging,e)}function u(e){return"string"==typeof e&&Object.values(s.p_).some((t=>t===e.toUpperCase().trim()))}},3969:(e,t,r)=>{"use strict";r.d(t,{TZ:()=>n,XG:()=>s,rs:()=>i,xV:()=>a,z_:()=>o});const n=r(860).K7.metrics,i="sm",o="cm",a="storeSupportabilityMetrics",s="storeEventMetrics"},6630:(e,t,r)=>{"use strict";r.d(t,{T:()=>n});const n=r(860).K7.pageViewEvent},782:(e,t,r)=>{"use strict";r.d(t,{T:()=>n});const n=r(860).K7.pageViewTiming},6344:(e,t,r)=>{"use strict";r.d(t,{BB:()=>d,G4:()=>o,Qb:()=>l,TZ:()=>i,Ug:()=>a,_s:()=>s,bc:()=>u,yP:()=>c});var n=r(2614);const i=r(860).K7.sessionReplay,o={RECORD:"recordReplay",PAUSE:"pauseReplay",REPLAY_RUNNING:"replayRunning",ERROR_DURING_REPLAY:"errorDuringReplay"},a=.12,s={DomContentLoaded:0,Load:1,FullSnapshot:2,IncrementalSnapshot:3,Meta:4,Custom:5},c={[n.g.ERROR]:15e3,[n.g.FULL]:3e5,[n.g.OFF]:0},u={RESET:{message:"Session was reset",sm:"Reset"},IMPORT:{message:"Recorder failed to import",sm:"Import"},TOO_MANY:{message:"429: Too Many Requests",sm:"Too-Many"},TOO_BIG:{message:"Payload was too large",sm:"Too-Big"},CROSS_TAB:{message:"Session Entity was set to OFF on another tab",sm:"Cross-Tab"},ENTITLEMENTS:{message:"Session Replay is not allowed and will not be started",sm:"Entitlement"}},d=5e3,l={API:"api"}},5270:(e,t,r)=>{"use strict";r.d(t,{Aw:()=>c,CT:()=>u,SR:()=>s});var n=r(384),i=r(9417),o=r(7767),a=r(6154);function s(e){return!!(0,n.dV)().o.MO&&(0,o.V)(e)&&!0===(0,i.gD)(e,"session_trace.enabled")}function c(e){return!0===(0,i.gD)(e,"session_replay.preload")&&s(e)}function u(e,t){const r=t.correctAbsoluteTimestamp(e);return{originalTimestamp:e,correctedTimestamp:r,timestampDiff:e-r,originTime:a.WN,correctedOriginTime:t.correctedOriginTime,originTimeDiff:Math.floor(a.WN-t.correctedOriginTime)}}},3738:(e,t,r)=>{"use strict";r.d(t,{He:()=>i,Kp:()=>s,Lc:()=>u,Rz:()=>d,TZ:()=>n,bD:()=>o,d3:()=>a,jx:()=>l,uP:()=>c});const n=r(860).K7.sessionTrace,i="bstResource",o="resource",a="-start",s="-end",c="fn"+a,u="fn"+s,d="pushState",l=1e3},3962:(e,t,r)=>{"use strict";r.d(t,{AM:()=>o,O2:()=>s,Qu:()=>c,TZ:()=>a,ih:()=>u,tC:()=>i});var n=r(860);const i=["click","keydown","submit"],o="api",a=n.K7.softNav,s={INITIAL_PAGE_LOAD:"",ROUTE_CHANGE:1,UNSPECIFIED:2},c={INTERACTION:1,AJAX:2,CUSTOM_END:3,CUSTOM_TRACER:4},u={IP:"in progress",FIN:"finished",CAN:"cancelled"}},7378:(e,t,r)=>{"use strict";r.d(t,{$p:()=>x,BR:()=>b,Kp:()=>R,L3:()=>y,Lc:()=>c,NC:()=>o,SG:()=>d,TZ:()=>i,U6:()=>p,UT:()=>m,d3:()=>w,dT:()=>f,e5:()=>A,gx:()=>v,l9:()=>l,oW:()=>h,op:()=>g,rw:()=>u,tH:()=>E,uP:()=>s,wW:()=>T,xq:()=>a});var n=r(384);const i=r(860).K7.spa,o=["click","submit","keypress","keydown","keyup","change"],a=999,s="fn-start",c="fn-end",u="cb-start",d="api-ixn-",l="remaining",f="interaction",h="spaNode",p="jsonpNode",g="fetch-start",m="fetch-done",v="fetch-body-",b="jsonp-end",y=(0,n.dV)().o.ST,w="-start",R="-end",x="-body",T="cb"+R,A="jsTime",E="fetch"},4234:(e,t,r)=>{"use strict";r.d(t,{W:()=>o});var n=r(7836),i=r(1687);class o{constructor(e,t){this.agentIdentifier=e,this.ee=n.ee.get(e),this.featureName=t,this.blocked=!1}deregisterDrain(){(0,i.x3)(this.agentIdentifier,this.featureName)}}},7767:(e,t,r)=>{"use strict";r.d(t,{V:()=>o});var n=r(9417),i=r(6154);const o=e=>i.RI&&!0===(0,n.gD)(e,"privacy.cookies_enabled")},425:(e,t,r)=>{"use strict";r.d(t,{j:()=>j});var n=r(860),i=r(2555),o=r(3371),a=r(9908),s=r(7836),c=r(1687),u=r(5289),d=r(6154),l=r(944),f=r(3969),h=r(384),p=r(6344);const g=["setErrorHandler","finished","addToTrace","addRelease","addPageAction","setCurrentRouteName","setPageViewName","setCustomAttribute","interaction","noticeError","setUserId","setApplicationVersion","start",p.G4.RECORD,p.G4.PAUSE,"log","wrapLogger"],m=["setErrorHandler","finished","addToTrace","addRelease"];var v=r(1863),b=r(2614),y=r(993),w=r(3785),R=r(2646),x=r(3434);function T(e,t,r,n){if("object"!=typeof t||!t||"string"!=typeof r||!r||"function"!=typeof t[r])return(0,l.R)(29);const i=function(e){return(e||s.ee).get("logger")}(e),o=(0,x.YM)(i),a=new R.y(s.P);return a.level=n.level,a.customAttributes=n.customAttributes,o.inPlace(t,[r],"wrap-logger-",a),i}function A(){const e=(0,h.pV)();g.forEach((t=>{e[t]=(...r)=>function(t,...r){let n=[];return Object.values(e.initializedAgents).forEach((e=>{e&&e.api?e.exposed&&e.api[t]&&n.push(e.api[t](...r)):(0,l.R)(38,t)})),n.length>1?n:n[0]}(t,...r)}))}const E={};var S=r(9417),N=r(5603),O=r(5284);const _=e=>{const t=e.startsWith("http");e+="/",r.p=t?e:"https://"+e};let I=!1;function j(e,t={},g,R){let{init:x,info:j,loader_config:P,runtime:C={},exposed:k=!0}=t;C.loaderType=g;const L=(0,h.pV)();j||(x=L.init,j=L.info,P=L.loader_config),(0,S.xN)(e.agentIdentifier,x||{}),(0,N.a)(e.agentIdentifier,P||{}),j.jsAttributes??={},d.bv&&(j.jsAttributes.isWorker=!0),(0,i.x1)(e.agentIdentifier,j);const H=(0,S.D0)(e.agentIdentifier),D=[j.beacon,j.errorBeacon];I||(H.proxy.assets&&(_(H.proxy.assets),D.push(H.proxy.assets)),H.proxy.beacon&&D.push(H.proxy.beacon),A(),(0,h.US)("activatedFeatures",O.B),e.runSoftNavOverSpa&&=!0===H.soft_navigations.enabled&&H.feature_flags.includes("soft_nav")),C.denyList=[...H.ajax.deny_list||[],...H.ajax.block_internal?D:[]],C.ptid=e.agentIdentifier,(0,o.V)(e.agentIdentifier,C),e.ee=s.ee.get(e.agentIdentifier),void 0===e.api&&(e.api=function(e,t,h=!1){t||(0,c.Ak)(e,"api");const g={};var R=s.ee.get(e),x=R.get("tracer");E[e]=b.g.OFF,R.on(p.G4.REPLAY_RUNNING,(t=>{E[e]=t}));var A="api-",S=A+"ixn-";function N(t,r,n,o){const a=(0,i.Vp)(e);return null===r?delete a.jsAttributes[t]:(0,i.x1)(e,{...a,jsAttributes:{...a.jsAttributes,[t]:r}}),I(A,n,!0,o||null===r?"session":void 0)(t,r)}function O(){}g.log=function(e,{customAttributes:t={},level:r=y.p_.INFO}={}){(0,a.p)(f.xV,["API/log/called"],void 0,n.K7.metrics,R),(0,w.R)(R,e,t,r)},g.wrapLogger=(e,t,{customAttributes:r={},level:i=y.p_.INFO}={})=>{(0,a.p)(f.xV,["API/wrapLogger/called"],void 0,n.K7.metrics,R),T(R,e,t,{customAttributes:r,level:i})},m.forEach((e=>{g[e]=I(A,e,!0,"api")})),g.addPageAction=I(A,"addPageAction",!0,n.K7.genericEvents),g.setPageViewName=function(t,r){if("string"==typeof t)return"/"!==t.charAt(0)&&(t="/"+t),(0,o.f)(e).customTransaction=(r||"http://custom.transaction")+t,I(A,"setPageViewName",!0)()},g.setCustomAttribute=function(e,t,r=!1){if("string"==typeof e){if(["string","number","boolean"].includes(typeof t)||null===t)return N(e,t,"setCustomAttribute",r);(0,l.R)(40,typeof t)}else(0,l.R)(39,typeof e)},g.setUserId=function(e){if("string"==typeof e||null===e)return N("enduser.id",e,"setUserId",!0);(0,l.R)(41,typeof e)},g.setApplicationVersion=function(e){if("string"==typeof e||null===e)return N("application.version",e,"setApplicationVersion",!1);(0,l.R)(42,typeof e)},g.start=()=>{try{(0,a.p)(f.xV,["API/start/called"],void 0,n.K7.metrics,R),R.emit("manual-start-all")}catch(e){(0,l.R)(23,e)}},g[p.G4.RECORD]=function(){(0,a.p)(f.xV,["API/recordReplay/called"],void 0,n.K7.metrics,R),(0,a.p)(p.G4.RECORD,[],void 0,n.K7.sessionReplay,R)},g[p.G4.PAUSE]=function(){(0,a.p)(f.xV,["API/pauseReplay/called"],void 0,n.K7.metrics,R),(0,a.p)(p.G4.PAUSE,[],void 0,n.K7.sessionReplay,R)},g.interaction=function(e){return(new O).get("object"==typeof e?e:{})};const _=O.prototype={createTracer:function(e,t){var r={},i=this,o="function"==typeof t;return(0,a.p)(f.xV,["API/createTracer/called"],void 0,n.K7.metrics,R),h||(0,a.p)(S+"tracer",[(0,v.t)(),e,r],i,n.K7.spa,R),function(){if(x.emit((o?"":"no-")+"fn-start",[(0,v.t)(),i,o],r),o)try{return t.apply(this,arguments)}catch(e){const t="string"==typeof e?new Error(e):e;throw x.emit("fn-err",[arguments,this,t],r),t}finally{x.emit("fn-end",[(0,v.t)()],r)}}}};function I(e,t,r,i){return function(){return(0,a.p)(f.xV,["API/"+t+"/called"],void 0,n.K7.metrics,R),i&&(0,a.p)(e+t,[(0,v.t)(),...arguments],r?null:this,i,R),r?void 0:this}}function j(){r.e(478).then(r.bind(r,8778)).then((({setAPI:t})=>{t(e),(0,c.Ze)(e,"api")})).catch((e=>{(0,l.R)(27,e),R.abort()}))}return["actionText","setName","setAttribute","save","ignore","onEnd","getContext","end","get"].forEach((e=>{_[e]=I(S,e,void 0,h?n.K7.softNav:n.K7.spa)})),g.setCurrentRouteName=h?I(S,"routeName",void 0,n.K7.softNav):I(A,"routeName",!0,n.K7.spa),g.noticeError=function(t,r){"string"==typeof t&&(t=new Error(t)),(0,a.p)(f.xV,["API/noticeError/called"],void 0,n.K7.metrics,R),(0,a.p)("err",[t,(0,v.t)(),!1,r,!!E[e]],void 0,n.K7.jserrors,R)},d.RI?(0,u.GG)((()=>j()),!0):j(),g}(e.agentIdentifier,R,e.runSoftNavOverSpa)),void 0===e.exposed&&(e.exposed=k),I=!0}},8374:(e,t,r)=>{r.nc=(()=>{try{return document?.currentScript?.nonce}catch(e){}return""})()},860:(e,t,r)=>{"use strict";r.d(t,{$J:()=>o,K7:()=>n,P3:()=>i});const n={ajax:"ajax",genericEvents:"generic_events",jserrors:"jserrors",logging:"logging",metrics:"metrics",pageAction:"page_action",pageViewEvent:"page_view_event",pageViewTiming:"page_view_timing",sessionReplay:"session_replay",sessionTrace:"session_trace",softNav:"soft_navigations",spa:"spa"},i={[n.pageViewEvent]:1,[n.pageViewTiming]:2,[n.metrics]:3,[n.jserrors]:4,[n.spa]:5,[n.ajax]:6,[n.sessionTrace]:7,[n.softNav]:8,[n.sessionReplay]:9,[n.logging]:10,[n.genericEvents]:11},o={[n.pageViewTiming]:"events",[n.ajax]:"events",[n.spa]:"events",[n.softNav]:"events",[n.metrics]:"jserrors",[n.jserrors]:"jserrors",[n.sessionTrace]:"browser/blobs",[n.sessionReplay]:"browser/blobs",[n.logging]:"browser/logs",[n.genericEvents]:"ins"}}},n={};function i(e){var t=n[e];if(void 0!==t)return t.exports;var o=n[e]={exports:{}};return r[e](o,o.exports,i),o.exports}i.m=r,i.d=(e,t)=>{for(var r in t)i.o(t,r)&&!i.o(e,r)&&Object.defineProperty(e,r,{enumerable:!0,get:t[r]})},i.f={},i.e=e=>Promise.all(Object.keys(i.f).reduce(((t,r)=>(i.f[r](e,t),t)),[])),i.u=e=>({212:"nr-spa-compressor",249:"nr-spa-recorder",478:"nr-spa"}[e]+"-1.274.0.min.js"),i.o=(e,t)=>Object.prototype.hasOwnProperty.call(e,t),e={},t="NRBA-1.274.0.PROD:",i.l=(r,n,o,a)=>{if(e[r])e[r].push(n);else{var s,c;if(void 0!==o)for(var u=document.getElementsByTagName("script"),d=0;d<u.length;d++){var l=u[d];if(l.getAttribute("src")==r||l.getAttribute("data-webpack")==t+o){s=l;break}}if(!s){c=!0;var f={478:"sha512-1vUqEfJPB8Pihje9mv5CfYgkitO1FWcS+UQb84DbXqP8oYctRv4/lzl/MzNLPlRhcY1WVDBGL20I8vm6s2VV7g==",249:"sha512-Y/BeZAh6VSTmUtUNmS5XdyKxL92s30Fyyj8xVW76HSPxcKItL4+x2+kGMZc8pMJnUpZDz1L4eftZQAJh3D8NnA==",212:"sha512-Gn2tQ3qog5Yhrx/gRutkSTYPp+7nkKFt4/mIXg99LxcNpMDAYJZDBYmAACdoHNM86+iq1F3cBcQotFNzjIX8bw=="};(s=document.createElement("script")).charset="utf-8",s.timeout=120,i.nc&&s.setAttribute("nonce",i.nc),s.setAttribute("data-webpack",t+o),s.src=r,0!==s.src.indexOf(window.location.origin+"/")&&(s.crossOrigin="anonymous"),f[a]&&(s.integrity=f[a])}e[r]=[n];var h=(t,n)=>{s.onerror=s.onload=null,clearTimeout(p);var i=e[r];if(delete e[r],s.parentNode&&s.parentNode.removeChild(s),i&&i.forEach((e=>e(n))),t)return t(n)},p=setTimeout(h.bind(null,void 0,{type:"timeout",target:s}),12e4);s.onerror=h.bind(null,s.onerror),s.onload=h.bind(null,s.onload),c&&document.head.appendChild(s)}},i.r=e=>{"undefined"!=typeof Symbol&&Symbol.toStringTag&&Object.defineProperty(e,Symbol.toStringTag,{value:"Module"}),Object.defineProperty(e,"__esModule",{value:!0})},i.p="https://js-agent.newrelic.com/",(()=>{var e={38:0,788:0};i.f.j=(t,r)=>{var n=i.o(e,t)?e[t]:void 0;if(0!==n)if(n)r.push(n[2]);else{var o=new Promise(((r,i)=>n=e[t]=[r,i]));r.push(n[2]=o);var a=i.p+i.u(t),s=new Error;i.l(a,(r=>{if(i.o(e,t)&&(0!==(n=e[t])&&(e[t]=void 0),n)){var o=r&&("load"===r.type?"missing":r.type),a=r&&r.target&&r.target.src;s.message="Loading chunk "+t+" failed.\n("+o+": "+a+")",s.name="ChunkLoadError",s.type=o,s.request=a,n[1](s)}}),"chunk-"+t,t)}};var t=(t,r)=>{var n,o,[a,s,c]=r,u=0;if(a.some((t=>0!==e[t]))){for(n in s)i.o(s,n)&&(i.m[n]=s[n]);if(c)c(i)}for(t&&t(r);u<a.length;u++)o=a[u],i.o(e,o)&&e[o]&&e[o][0](),e[o]=0},r=self["webpackChunk:NRBA-1.274.0.PROD"]=self["webpackChunk:NRBA-1.274.0.PROD"]||[];r.forEach(t.bind(null,0)),r.push=t.bind(null,r.push.bind(r))})(),(()=>{"use strict";i(8374);var e=i(944),t=i(6344),r=i(9566);class n{agentIdentifier;constructor(e=(0,r.LA)(16)){this.agentIdentifier=e}#e(t,...r){if("function"==typeof this.api?.[t])return this.api[t](...r);(0,e.R)(35,t)}addPageAction(e,t){return this.#e("addPageAction",e,t)}setPageViewName(e,t){return this.#e("setPageViewName",e,t)}setCustomAttribute(e,t,r){return this.#e("setCustomAttribute",e,t,r)}noticeError(e,t){return this.#e("noticeError",e,t)}setUserId(e){return this.#e("setUserId",e)}setApplicationVersion(e){return this.#e("setApplicationVersion",e)}setErrorHandler(e){return this.#e("setErrorHandler",e)}addRelease(e,t){return this.#e("addRelease",e,t)}log(e,t){return this.#e("log",e,t)}}class o extends n{#e(t,...r){if("function"==typeof this.api?.[t])return this.api[t](...r);(0,e.R)(35,t)}start(){return this.#e("start")}finished(e){return this.#e("finished",e)}recordReplay(){return this.#e(t.G4.RECORD)}pauseReplay(){return this.#e(t.G4.PAUSE)}addToTrace(e){return this.#e("addToTrace",e)}setCurrentRouteName(e){return this.#e("setCurrentRouteName",e)}interaction(){return this.#e("interaction")}wrapLogger(e,t,r){return this.#e("wrapLogger",e,t,r)}}var a=i(860),s=i(9417);const c=Object.values(a.K7);function u(e){const t={};return c.forEach((r=>{t[r]=function(e,t){return!0===(0,s.gD)(t,"".concat(e,".enabled"))}(r,e)})),t}var d=i(425);var l=i(1687),f=i(4234),h=i(5289),p=i(6154),g=i(5270),m=i(7767),v=i(6389);class b extends f.W{constructor(e,t,r=!0){super(e.agentIdentifier,t),this.auto=r,this.abortHandler=void 0,this.featAggregate=void 0,this.onAggregateImported=void 0,!1===e.init[this.featureName].autoStart&&(this.auto=!1),this.auto?(0,l.Ak)(e.agentIdentifier,t):this.ee.on("manual-start-all",(0,v.J)((()=>{(0,l.Ak)(e.agentIdentifier,this.featureName),this.auto=!0,this.importAggregator(e)})))}importAggregator(t,r={}){if(this.featAggregate||!this.auto)return;let n;this.onAggregateImported=new Promise((e=>{n=e}));const o=async()=>{let o;try{if((0,m.V)(this.agentIdentifier)){const{setupAgentSession:e}=await i.e(478).then(i.bind(i,6526));o=e(t)}}catch(t){(0,e.R)(20,t),this.ee.emit("internal-error",[t]),this.featureName===a.K7.sessionReplay&&this.abortHandler?.()}try{if(t.sharedAggregator)await t.sharedAggregator;else{t.sharedAggregator=i.e(478).then(i.bind(i,9337));const{EventAggregator:e}=await t.sharedAggregator;t.sharedAggregator=new e}if(!this.#t(this.featureName,o))return(0,l.Ze)(this.agentIdentifier,this.featureName),void n(!1);const{lazyFeatureLoader:e}=await i.e(478).then(i.bind(i,6103)),{Aggregate:a}=await e(this.featureName,"aggregate");this.featAggregate=new a(t,r),n(!0)}catch(t){(0,e.R)(34,t),this.abortHandler?.(),(0,l.Ze)(this.agentIdentifier,this.featureName,!0),n(!1),this.ee&&this.ee.abort()}};p.RI?(0,h.GG)((()=>o()),!0):o()}#t(e,t){switch(e){case a.K7.sessionReplay:return(0,g.SR)(this.agentIdentifier)&&!!t;case a.K7.sessionTrace:return!!t;default:return!0}}}var y=i(6630);class w extends b{static featureName=y.T;constructor(e,t=!0){super(e,y.T,t),this.importAggregator(e)}}var R=i(384);var x=i(9908),T=i(2843),A=i(3878),E=i(782),S=i(1863);class N extends b{static featureName=E.T;constructor(e,t=!0){super(e,E.T,t),p.RI&&((0,T.u)((()=>(0,x.p)("docHidden",[(0,S.t)()],void 0,E.T,this.ee)),!0),(0,A.sp)("pagehide",(()=>(0,x.p)("winPagehide",[(0,S.t)()],void 0,E.T,this.ee))),this.importAggregator(e))}}var O=i(3969);class _ extends b{static featureName=O.TZ;constructor(e,t=!0){super(e,O.TZ,t),this.importAggregator(e)}}var I=i(6774),j=i(3304);class P{constructor(e,t,r,n,i){this.name="UncaughtError",this.message="string"==typeof e?e:(0,j.A)(e),this.sourceURL=t,this.line=r,this.column=n,this.__newrelic=i}}function C(e){return H(e)?e:new P(void 0!==e?.message?e.message:e,e?.filename||e?.sourceURL,e?.lineno||e?.line,e?.colno||e?.col,e?.__newrelic)}function k(e){const t="Unhandled Promise Rejection";if(!e?.reason)return;if(H(e.reason))try{return e.reason.message=t+": "+e.reason.message,C(e.reason)}catch(t){return C(e.reason)}const r=C(e.reason);return r.message=t+": "+r?.message,r}function L(e){if(e.error instanceof SyntaxError&&!/:\d+$/.test(e.error.stack?.trim())){const t=new P(e.message,e.filename,e.lineno,e.colno,e.error.__newrelic);return t.name=SyntaxError.name,t}return H(e.error)?e.error:C(e)}function H(e){return e instanceof Error&&!!e.stack}class D extends b{static featureName=I.T;#r=!1;constructor(e,r=!0){super(e,I.T,r);try{this.removeOnAbort=new AbortController}catch(e){}this.ee.on("internal-error",(e=>{this.abortHandler&&(0,x.p)("ierr",[C(e),(0,S.t)(),!0,{},this.#r],void 0,this.featureName,this.ee)})),this.ee.on(t.G4.REPLAY_RUNNING,(e=>{this.#r=e})),p.gm.addEventListener("unhandledrejection",(e=>{this.abortHandler&&(0,x.p)("err",[k(e),(0,S.t)(),!1,{unhandledPromiseRejection:1},this.#r],void 0,this.featureName,this.ee)}),(0,A.jT)(!1,this.removeOnAbort?.signal)),p.gm.addEventListener("error",(e=>{this.abortHandler&&(0,x.p)("err",[L(e),(0,S.t)(),!1,{},this.#r],void 0,this.featureName,this.ee)}),(0,A.jT)(!1,this.removeOnAbort?.signal)),this.abortHandler=this.#n,this.importAggregator(e)}#n(){this.removeOnAbort?.abort(),this.abortHandler=void 0}}var M=i(8990);let K=1;const U="nr@id";function V(e){const t=typeof e;return!e||"object"!==t&&"function"!==t?-1:e===p.gm?0:(0,M.I)(e,U,(function(){return K++}))}function G(e){if("string"==typeof e&&e.length)return e.length;if("object"==typeof e){if("undefined"!=typeof ArrayBuffer&&e instanceof ArrayBuffer&&e.byteLength)return e.byteLength;if("undefined"!=typeof Blob&&e instanceof Blob&&e.size)return e.size;if(!("undefined"!=typeof FormData&&e instanceof FormData))try{return(0,j.A)(e).length}catch(e){return}}}var F=i(8139),B=i(7836),W=i(3434);const z={},q=["open","send"];function Z(t){var r=t||B.ee;const n=function(e){return(e||B.ee).get("xhr")}(r);if(z[n.debugId]++)return n;z[n.debugId]=1,(0,F.u)(r);var i=(0,W.YM)(n),o=p.gm.XMLHttpRequest,a=p.gm.MutationObserver,s=p.gm.Promise,c=p.gm.setInterval,u="readystatechange",d=["onload","onerror","onabort","onloadstart","onloadend","onprogress","ontimeout"],l=[],f=p.gm.XMLHttpRequest=function(t){const r=new o(t),a=n.context(r);try{n.emit("new-xhr",[r],a),r.addEventListener(u,(s=a,function(){var e=this;e.readyState>3&&!s.resolved&&(s.resolved=!0,n.emit("xhr-resolved",[],e)),i.inPlace(e,d,"fn-",y)}),(0,A.jT)(!1))}catch(t){(0,e.R)(15,t);try{n.emit("internal-error",[t])}catch(e){}}var s;return r};function h(e,t){i.inPlace(t,["onreadystatechange"],"fn-",y)}if(function(e,t){for(var r in e)t[r]=e[r]}(o,f),f.prototype=o.prototype,i.inPlace(f.prototype,q,"-xhr-",y),n.on("send-xhr-start",(function(e,t){h(e,t),function(e){l.push(e),a&&(g?g.then(b):c?c(b):(m=-m,v.data=m))}(t)})),n.on("open-xhr-start",h),a){var g=s&&s.resolve();if(!c&&!s){var m=1,v=document.createTextNode(m);new a(b).observe(v,{characterData:!0})}}else r.on("fn-end",(function(e){e[0]&&e[0].type===u||b()}));function b(){for(var e=0;e<l.length;e++)h(0,l[e]);l.length&&(l=[])}function y(e,t){return t}return n}var Y="fetch-",X=Y+"body-",J=["arrayBuffer","blob","json","text","formData"],Q=p.gm.Request,ee=p.gm.Response,te="prototype";const re={};function ne(e){const t=function(e){return(e||B.ee).get("fetch")}(e);if(!(Q&&ee&&p.gm.fetch))return t;if(re[t.debugId]++)return t;function r(e,r,n){var i=e[r];"function"==typeof i&&(e[r]=function(){var e,r=[...arguments],o={};t.emit(n+"before-start",[r],o),o[B.P]&&o[B.P].dt&&(e=o[B.P].dt);var a=i.apply(this,r);return t.emit(n+"start",[r,e],a),a.then((function(e){return t.emit(n+"end",[null,e],a),e}),(function(e){throw t.emit(n+"end",[e],a),e}))})}return re[t.debugId]=1,J.forEach((e=>{r(Q[te],e,X),r(ee[te],e,X)})),r(p.gm,"fetch",Y),t.on(Y+"end",(function(e,r){var n=this;if(r){var i=r.headers.get("content-length");null!==i&&(n.rxSize=i),t.emit(Y+"done",[null,r],n)}else t.emit(Y+"done",[e],n)})),t}var ie=i(7485),oe=i(5603);class ae{constructor(e){this.agentIdentifier=e}generateTracePayload(e){if(!this.shouldGenerateTrace(e))return null;var t=(0,oe.o)(this.agentIdentifier);if(!t)return null;var n=(t.accountID||"").toString()||null,i=(t.agentID||"").toString()||null,o=(t.trustKey||"").toString()||null;if(!n||!i)return null;var a=(0,r.ZF)(),s=(0,r.el)(),c=Date.now(),u={spanId:a,traceId:s,timestamp:c};return(e.sameOrigin||this.isAllowedOrigin(e)&&this.useTraceContextHeadersForCors())&&(u.traceContextParentHeader=this.generateTraceContextParentHeader(a,s),u.traceContextStateHeader=this.generateTraceContextStateHeader(a,c,n,i,o)),(e.sameOrigin&&!this.excludeNewrelicHeader()||!e.sameOrigin&&this.isAllowedOrigin(e)&&this.useNewrelicHeaderForCors())&&(u.newrelicHeader=this.generateTraceHeader(a,s,c,n,i,o)),u}generateTraceContextParentHeader(e,t){return"00-"+t+"-"+e+"-01"}generateTraceContextStateHeader(e,t,r,n,i){return i+"@nr=0-1-"+r+"-"+n+"-"+e+"----"+t}generateTraceHeader(e,t,r,n,i,o){if(!("function"==typeof p.gm?.btoa))return null;var a={v:[0,1],d:{ty:"Browser",ac:n,ap:i,id:e,tr:t,ti:r}};return o&&n!==o&&(a.d.tk=o),btoa((0,j.A)(a))}shouldGenerateTrace(e){return this.isDtEnabled()&&this.isAllowedOrigin(e)}isAllowedOrigin(e){var t=!1,r={};if((0,s.gD)(this.agentIdentifier,"distributed_tracing")&&(r=(0,s.D0)(this.agentIdentifier).distributed_tracing),e.sameOrigin)t=!0;else if(r.allowed_origins instanceof Array)for(var n=0;n<r.allowed_origins.length;n++){var i=(0,ie.D)(r.allowed_origins[n]);if(e.hostname===i.hostname&&e.protocol===i.protocol&&e.port===i.port){t=!0;break}}return t}isDtEnabled(){var e=(0,s.gD)(this.agentIdentifier,"distributed_tracing");return!!e&&!!e.enabled}excludeNewrelicHeader(){var e=(0,s.gD)(this.agentIdentifier,"distributed_tracing");return!!e&&!!e.exclude_newrelic_header}useNewrelicHeaderForCors(){var e=(0,s.gD)(this.agentIdentifier,"distributed_tracing");return!!e&&!1!==e.cors_use_newrelic_header}useTraceContextHeadersForCors(){var e=(0,s.gD)(this.agentIdentifier,"distributed_tracing");return!!e&&!!e.cors_use_tracecontext_headers}}var se=i(9300),ce=i(7295),ue=["load","error","abort","timeout"],de=ue.length,le=(0,R.dV)().o.REQ,fe=(0,R.dV)().o.XHR;class he extends b{static featureName=se.T;constructor(e,t=!0){super(e,se.T,t),this.dt=new ae(e.agentIdentifier),this.handler=(e,t,r,n)=>(0,x.p)(e,t,r,n,this.ee);try{const e={xmlhttprequest:"xhr",fetch:"fetch",beacon:"beacon"};p.gm?.performance?.getEntriesByType("resource").forEach((t=>{if(t.initiatorType in e&&0!==t.responseStatus){const r={status:t.responseStatus},n={rxSize:t.transferSize,duration:Math.floor(t.duration),cbTime:0};pe(r,t.name),this.handler("xhr",[r,n,t.startTime,t.responseEnd,e[t.initiatorType]],void 0,a.K7.ajax)}}))}catch(e){}ne(this.ee),Z(this.ee),function(e,t,r,n){function i(e){var t=this;t.totalCbs=0,t.called=0,t.cbTime=0,t.end=R,t.ended=!1,t.xhrGuids={},t.lastSize=null,t.loadCaptureCalled=!1,t.params=this.params||{},t.metrics=this.metrics||{},e.addEventListener("load",(function(r){T(t,e)}),(0,A.jT)(!1)),p.lR||e.addEventListener("progress",(function(e){t.lastSize=e.loaded}),(0,A.jT)(!1))}function o(e){this.params={method:e[0]},pe(this,e[1]),this.metrics={}}function s(t,r){e.loader_config.xpid&&this.sameOrigin&&r.setRequestHeader("X-NewRelic-ID",e.loader_config.xpid);var i=n.generateTracePayload(this.parsedOrigin);if(i){var o=!1;i.newrelicHeader&&(r.setRequestHeader("newrelic",i.newrelicHeader),o=!0),i.traceContextParentHeader&&(r.setRequestHeader("traceparent",i.traceContextParentHeader),i.traceContextStateHeader&&r.setRequestHeader("tracestate",i.traceContextStateHeader),o=!0),o&&(this.dt=i)}}function c(e,r){var n=this.metrics,i=e[0],o=this;if(n&&i){var a=G(i);a&&(n.txSize=a)}this.startTime=(0,S.t)(),this.body=i,this.listener=function(e){try{"abort"!==e.type||o.loadCaptureCalled||(o.params.aborted=!0),("load"!==e.type||o.called===o.totalCbs&&(o.onloadCalled||"function"!=typeof r.onload)&&"function"==typeof o.end)&&o.end(r)}catch(e){try{t.emit("internal-error",[e])}catch(e){}}};for(var s=0;s<de;s++)r.addEventListener(ue[s],this.listener,(0,A.jT)(!1))}function u(e,t,r){this.cbTime+=e,t?this.onloadCalled=!0:this.called+=1,this.called!==this.totalCbs||!this.onloadCalled&&"function"==typeof r.onload||"function"!=typeof this.end||this.end(r)}function d(e,t){var r=""+V(e)+!!t;this.xhrGuids&&!this.xhrGuids[r]&&(this.xhrGuids[r]=!0,this.totalCbs+=1)}function l(e,t){var r=""+V(e)+!!t;this.xhrGuids&&this.xhrGuids[r]&&(delete this.xhrGuids[r],this.totalCbs-=1)}function f(){this.endTime=(0,S.t)()}function h(e,r){r instanceof fe&&"load"===e[0]&&t.emit("xhr-load-added",[e[1],e[2]],r)}function g(e,r){r instanceof fe&&"load"===e[0]&&t.emit("xhr-load-removed",[e[1],e[2]],r)}function m(e,t,r){t instanceof fe&&("onload"===r&&(this.onload=!0),("load"===(e[0]&&e[0].type)||this.onload)&&(this.xhrCbStart=(0,S.t)()))}function v(e,r){this.xhrCbStart&&t.emit("xhr-cb-time",[(0,S.t)()-this.xhrCbStart,this.onload,r],r)}function b(e){var t,r=e[1]||{};if("string"==typeof e[0]?0===(t=e[0]).length&&p.RI&&(t=""+p.gm.location.href):e[0]&&e[0].url?t=e[0].url:p.gm?.URL&&e[0]&&e[0]instanceof URL?t=e[0].href:"function"==typeof e[0].toString&&(t=e[0].toString()),"string"==typeof t&&0!==t.length){t&&(this.parsedOrigin=(0,ie.D)(t),this.sameOrigin=this.parsedOrigin.sameOrigin);var i=n.generateTracePayload(this.parsedOrigin);if(i&&(i.newrelicHeader||i.traceContextParentHeader))if(e[0]&&e[0].headers)s(e[0].headers,i)&&(this.dt=i);else{var o={};for(var a in r)o[a]=r[a];o.headers=new Headers(r.headers||{}),s(o.headers,i)&&(this.dt=i),e.length>1?e[1]=o:e.push(o)}}function s(e,t){var r=!1;return t.newrelicHeader&&(e.set("newrelic",t.newrelicHeader),r=!0),t.traceContextParentHeader&&(e.set("traceparent",t.traceContextParentHeader),t.traceContextStateHeader&&e.set("tracestate",t.traceContextStateHeader),r=!0),r}}function y(e,t){this.params={},this.metrics={},this.startTime=(0,S.t)(),this.dt=t,e.length>=1&&(this.target=e[0]),e.length>=2&&(this.opts=e[1]);var r,n=this.opts||{},i=this.target;"string"==typeof i?r=i:"object"==typeof i&&i instanceof le?r=i.url:p.gm?.URL&&"object"==typeof i&&i instanceof URL&&(r=i.href),pe(this,r);var o=(""+(i&&i instanceof le&&i.method||n.method||"GET")).toUpperCase();this.params.method=o,this.body=n.body,this.txSize=G(n.body)||0}function w(e,t){if(this.endTime=(0,S.t)(),this.params||(this.params={}),(0,ce.iW)(this.params))return;let n;this.params.status=t?t.status:0,"string"==typeof this.rxSize&&this.rxSize.length>0&&(n=+this.rxSize);const i={txSize:this.txSize,rxSize:n,duration:(0,S.t)()-this.startTime};r("xhr",[this.params,i,this.startTime,this.endTime,"fetch"],this,a.K7.ajax)}function R(e){const t=this.params,n=this.metrics;if(!this.ended){this.ended=!0;for(let t=0;t<de;t++)e.removeEventListener(ue[t],this.listener,!1);t.aborted||(0,ce.iW)(t)||(n.duration=(0,S.t)()-this.startTime,this.loadCazptureCalled||4!==e.readyState?null==t.status&&(t.status=0):T(this,e),n.cbTime=this.cbTime,r("xhr",[t,n,this.startTime,this.endTime,"xhr"],this,a.K7.ajax))}}function T(e,r){e.params.status=r.status;var n=function(e,t){var r=e.responseType;return"json"===r&&null!==t?t:"arraybuffer"===r||"blob"===r||"json"===r?G(e.response):"text"===r||""===r||void 0===r?G(e.responseText):void 0}(r,e.lastSize);if(n&&(e.metrics.rxSize=n),e.sameOrigin){var i=r.getResponseHeader("X-NewRelic-App-Data");i&&((0,x.p)(O.rs,["Ajax/CrossApplicationTracing/Header/Seen"],void 0,a.K7.metrics,t),e.params.cat=i.split(", ").pop())}e.loadCaptureCalled=!0}t.on("new-xhr",i),t.on("open-xhr-start",o),t.on("open-xhr-end",s),t.on("send-xhr-start",c),t.on("xhr-cb-time",u),t.on("xhr-load-added",d),t.on("xhr-load-removed",l),t.on("xhr-resolved",f),t.on("addEventListener-end",h),t.on("removeEventListener-end",g),t.on("fn-end",v),t.on("fetch-before-start",b),t.on("fetch-start",y),t.on("fn-start",m),t.on("fetch-done",w)}(e,this.ee,this.handler,this.dt),this.importAggregator(e)}}function pe(e,t){var r=(0,ie.D)(t),n=e.params||e;n.hostname=r.hostname,n.port=r.port,n.protocol=r.protocol,n.host=r.hostname+":"+r.port,n.pathname=r.pathname,e.parsedOrigin=r,e.sameOrigin=r.sameOrigin}const ge={},me=["pushState","replaceState"];function ve(e){const t=function(e){return(e||B.ee).get("history")}(e);return!p.RI||ge[t.debugId]++||(ge[t.debugId]=1,(0,W.YM)(t).inPlace(window.history,me,"-")),t}var be=i(3738);const{He:ye,bD:we,d3:Re,Kp:xe,TZ:Te,Lc:Ae,uP:Ee,Rz:Se}=be;class Ne extends b{static featureName=Te;constructor(e,t=!0){super(e,Te,t);if(!(0,m.V)(this.agentIdentifier))return void this.deregisterDrain();const r=this.ee;let n;ve(r),this.eventsEE=(0,F.u)(r),this.eventsEE.on(Ee,(function(e,t){this.bstStart=(0,S.t)()})),this.eventsEE.on(Ae,(function(e,t){(0,x.p)("bst",[e[0],t,this.bstStart,(0,S.t)()],void 0,a.K7.sessionTrace,r)})),r.on(Se+Re,(function(e){this.time=(0,S.t)(),this.startPath=location.pathname+location.hash})),r.on(Se+xe,(function(e){(0,x.p)("bstHist",[location.pathname+location.hash,this.startPath,this.time],void 0,a.K7.sessionTrace,r)}));try{n=new PerformanceObserver((e=>{const t=e.getEntries();(0,x.p)(ye,[t],void 0,a.K7.sessionTrace,r)})),n.observe({type:we,buffered:!0})}catch(e){}this.importAggregator(e,{resourceObserver:n})}}var Oe=i(2614);class _e extends b{static featureName=t.TZ;#i;#o;constructor(e,r=!0){let n;super(e,t.TZ,r),this.replayRunning=!1,this.#o=e;try{n=JSON.parse(localStorage.getItem("".concat(Oe.H3,"_").concat(Oe.uh)))}catch(e){}(0,g.SR)(e.agentIdentifier)&&this.ee.on(t.G4.RECORD,(()=>this.#a())),this.#s(n)?(this.#i=n?.sessionReplayMode,this.#c()):this.importAggregator(e),this.ee.on("err",(e=>{this.replayRunning&&(this.errorNoticed=!0,(0,x.p)(t.G4.ERROR_DURING_REPLAY,[e],void 0,this.featureName,this.ee))})),this.ee.on(t.G4.REPLAY_RUNNING,(e=>{this.replayRunning=e}))}#s(e){return e&&(e.sessionReplayMode===Oe.g.FULL||e.sessionReplayMode===Oe.g.ERROR)||(0,g.Aw)(this.agentIdentifier)}#u=!1;async#c(e){if(!this.#u){this.#u=!0;try{const{Recorder:t}=await Promise.all([i.e(478),i.e(249)]).then(i.bind(i,8589));this.recorder??=new t({mode:this.#i,agentIdentifier:this.agentIdentifier,trigger:e,ee:this.ee}),this.recorder.startRecording(),this.abortHandler=this.recorder.stopRecording}catch(e){}this.importAggregator(this.#o,{recorder:this.recorder,errorNoticed:this.errorNoticed})}}#a(){this.featAggregate?this.featAggregate.mode!==Oe.g.FULL&&this.featAggregate.initializeRecording(Oe.g.FULL,!0):(this.#i=Oe.g.FULL,this.#c(t.Qb.API),this.recorder&&this.recorder.parent.mode!==Oe.g.FULL&&(this.recorder.parent.mode=Oe.g.FULL,this.recorder.stopRecording(),this.recorder.startRecording(),this.abortHandler=this.recorder.stopRecording))}}var Ie=i(3962);class je extends b{static featureName=Ie.TZ;constructor(e,t=!0){if(super(e,Ie.TZ,t),!p.RI||!(0,R.dV)().o.MO)return;const r=ve(this.ee);Ie.tC.forEach((e=>{(0,A.sp)(e,(e=>{a(e)}),!0)}));const n=()=>(0,x.p)("newURL",[(0,S.t)(),""+window.location],void 0,this.featureName,this.ee);r.on("pushState-end",n),r.on("replaceState-end",n);try{this.removeOnAbort=new AbortController}catch(e){}(0,A.sp)("popstate",(e=>(0,x.p)("newURL",[e.timeStamp,""+window.location],void 0,this.featureName,this.ee)),!0,this.removeOnAbort?.signal);let i=!1;const o=new((0,R.dV)().o.MO)(((e,t)=>{i||(i=!0,requestAnimationFrame((()=>{(0,x.p)("newDom",[(0,S.t)()],void 0,this.featureName,this.ee),i=!1})))})),a=(0,v.s)((e=>{(0,x.p)("newUIEvent",[e],void 0,this.featureName,this.ee),o.observe(document.body,{attributes:!0,childList:!0,subtree:!0,characterData:!0})}),100,{leading:!0});this.abortHandler=function(){this.removeOnAbort?.abort(),o.disconnect(),this.abortHandler=void 0},this.importAggregator(e,{domObserver:o})}}var Pe=i(7378);const Ce={},ke=["appendChild","insertBefore","replaceChild"];function Le(e){const t=function(e){return(e||B.ee).get("jsonp")}(e);if(!p.RI||Ce[t.debugId])return t;Ce[t.debugId]=!0;var r=(0,W.YM)(t),n=/[?&](?:callback|cb)=([^&#]+)/,i=/(.*)\.([^.]+)/,o=/^(\w+)(\.|$)(.*)$/;function a(e,t){if(!e)return t;const r=e.match(o),n=r[1];return a(r[3],t[n])}return r.inPlace(Node.prototype,ke,"dom-"),t.on("dom-start",(function(e){!function(e){if(!e||"string"!=typeof e.nodeName||"script"!==e.nodeName.toLowerCase())return;if("function"!=typeof e.addEventListener)return;var o=(s=e.src,c=s.match(n),c?c[1]:null);var s,c;if(!o)return;var u=function(e){var t=e.match(i);if(t&&t.length>=3)return{key:t[2],parent:a(t[1],window)};return{key:e,parent:window}}(o);if("function"!=typeof u.parent[u.key])return;var d={};function l(){t.emit("jsonp-end",[],d),e.removeEventListener("load",l,(0,A.jT)(!1)),e.removeEventListener("error",f,(0,A.jT)(!1))}function f(){t.emit("jsonp-error",[],d),t.emit("jsonp-end",[],d),e.removeEventListener("load",l,(0,A.jT)(!1)),e.removeEventListener("error",f,(0,A.jT)(!1))}r.inPlace(u.parent,[u.key],"cb-",d),e.addEventListener("load",l,(0,A.jT)(!1)),e.addEventListener("error",f,(0,A.jT)(!1)),t.emit("new-jsonp",[e.src],d)}(e[0])})),t}const He={};function De(e){const t=function(e){return(e||B.ee).get("promise")}(e);if(He[t.debugId])return t;He[t.debugId]=!0;var r=t.context,n=(0,W.YM)(t),i=p.gm.Promise;return i&&function(){function e(r){var o=t.context(),a=n(r,"executor-",o,null,!1);const s=Reflect.construct(i,[a],e);return t.context(s).getCtx=function(){return o},s}p.gm.Promise=e,Object.defineProperty(e,"name",{value:"Promise"}),e.toString=function(){return i.toString()},Object.setPrototypeOf(e,i),["all","race"].forEach((function(r){const n=i[r];e[r]=function(e){let i=!1;[...e||[]].forEach((e=>{this.resolve(e).then(a("all"===r),a(!1))}));const o=n.apply(this,arguments);return o;function a(e){return function(){t.emit("propagate",[null,!i],o,!1,!1),i=i||!e}}}})),["resolve","reject"].forEach((function(r){const n=i[r];e[r]=function(e){const r=n.apply(this,arguments);return e!==r&&t.emit("propagate",[e,!0],r,!1,!1),r}})),e.prototype=i.prototype;const o=i.prototype.then;i.prototype.then=function(...e){var i=this,a=r(i);a.promise=i,e[0]=n(e[0],"cb-",a,null,!1),e[1]=n(e[1],"cb-",a,null,!1);const s=o.apply(this,e);return a.nextPromise=s,t.emit("propagate",[i,!0],s,!1,!1),s},i.prototype.then[W.Jt]=o,t.on("executor-start",(function(e){e[0]=n(e[0],"resolve-",this,null,!1),e[1]=n(e[1],"resolve-",this,null,!1)})),t.on("executor-err",(function(e,t,r){e[1](r)})),t.on("cb-end",(function(e,r,n){t.emit("propagate",[n,!0],this.nextPromise,!1,!1)})),t.on("propagate",(function(e,r,n){this.getCtx&&!r||(this.getCtx=function(){if(e instanceof Promise)var r=t.context(e);return r&&r.getCtx?r.getCtx():this})}))}(),t}const Me={},Ke="setTimeout",Ue="setInterval",Ve="clearTimeout",Ge="-start",Fe=[Ke,"setImmediate",Ue,Ve,"clearImmediate"];function Be(e){const t=function(e){return(e||B.ee).get("timer")}(e);if(Me[t.debugId]++)return t;Me[t.debugId]=1;var r=(0,W.YM)(t);return r.inPlace(p.gm,Fe.slice(0,2),Ke+"-"),r.inPlace(p.gm,Fe.slice(2,3),Ue+"-"),r.inPlace(p.gm,Fe.slice(3),Ve+"-"),t.on(Ue+Ge,(function(e,t,n){e[0]=r(e[0],"fn-",null,n)})),t.on(Ke+Ge,(function(e,t,n){this.method=n,this.timerDuration=isNaN(e[1])?0:+e[1],e[0]=r(e[0],"fn-",this,n)})),t}const We={};function ze(e){const t=function(e){return(e||B.ee).get("mutation")}(e);if(!p.RI||We[t.debugId])return t;We[t.debugId]=!0;var r=(0,W.YM)(t),n=p.gm.MutationObserver;return n&&(window.MutationObserver=function(e){return this instanceof n?new n(r(e,"fn-")):n.apply(this,arguments)},MutationObserver.prototype=n.prototype),t}const{TZ:qe,d3:Ze,Kp:Ye,$p:Xe,wW:Je,e5:Qe,tH:$e,uP:et,rw:tt,Lc:rt}=Pe;class nt extends b{static featureName=qe;constructor(e,t=!0){if(super(e,qe,t),!p.RI)return;try{this.removeOnAbort=new AbortController}catch(e){}let r,n=0;const i=this.ee.get("tracer"),o=Le(this.ee),a=De(this.ee),s=Be(this.ee),c=Z(this.ee),u=this.ee.get("events"),d=ne(this.ee),l=ve(this.ee),f=ze(this.ee);function h(e,t){l.emit("newURL",[""+window.location,t])}function g(){n++,r=window.location.hash,this[et]=(0,S.t)()}function m(){n--,window.location.hash!==r&&h(0,!0);var e=(0,S.t)();this[Qe]=~~this[Qe]+e-this[et],this[rt]=e}function v(e,t){e.on(t,(function(){this[t]=(0,S.t)()}))}this.ee.on(et,g),a.on(tt,g),o.on(tt,g),this.ee.on(rt,m),a.on(Je,m),o.on(Je,m),this.ee.on("fn-err",((...t)=>{t[2]?.__newrelic?.[e.agentIdentifier]||(0,x.p)("function-err",[...t],void 0,this.featureName,this.ee)})),this.ee.buffer([et,rt,"xhr-resolved"],this.featureName),u.buffer([et],this.featureName),s.buffer(["setTimeout"+Ye,"clearTimeout"+Ze,et],this.featureName),c.buffer([et,"new-xhr","send-xhr"+Ze],this.featureName),d.buffer([$e+Ze,$e+"-done",$e+Xe+Ze,$e+Xe+Ye],this.featureName),l.buffer(["newURL"],this.featureName),f.buffer([et],this.featureName),a.buffer(["propagate",tt,Je,"executor-err","resolve"+Ze],this.featureName),i.buffer([et,"no-"+et],this.featureName),o.buffer(["new-jsonp","cb-start","jsonp-error","jsonp-end"],this.featureName),v(d,$e+Ze),v(d,$e+"-done"),v(o,"new-jsonp"),v(o,"jsonp-end"),v(o,"cb-start"),l.on("pushState-end",h),l.on("replaceState-end",h),window.addEventListener("hashchange",h,(0,A.jT)(!0,this.removeOnAbort?.signal)),window.addEventListener("load",h,(0,A.jT)(!0,this.removeOnAbort?.signal)),window.addEventListener("popstate",(function(){h(0,n>1)}),(0,A.jT)(!0,this.removeOnAbort?.signal)),this.abortHandler=this.#n,this.importAggregator(e)}#n(){this.removeOnAbort?.abort(),this.abortHandler=void 0}}var it=i(3333);class ot extends b{static featureName=it.TZ;constructor(e,t=!0){super(e,it.TZ,t);const r=[e.init.page_action.enabled,e.init.performance.capture_marks,e.init.performance.capture_measures,e.init.user_actions.enabled];p.RI&&e.init.user_actions.enabled&&(it.Zp.forEach((e=>(0,A.sp)(e,(e=>(0,x.p)("ua",[e],void 0,this.featureName,this.ee)),!0))),it.qN.forEach((e=>(0,A.sp)(e,(e=>(0,x.p)("ua",[e],void 0,this.featureName,this.ee)))))),r.some((e=>e))?this.importAggregator(e):this.deregisterDrain()}}var at=i(993),st=i(3785);class ct extends b{static featureName=at.TZ;constructor(e,t=!0){super(e,at.TZ,t);const r=this.ee;this.ee.on("wrap-logger-end",(function([e]){const{level:t,customAttributes:n}=this;(0,st.R)(r,e,n,t)})),this.importAggregator(e)}}new class extends o{constructor(t,r){super(r),p.gm?(this.features={},(0,R.bQ)(this.agentIdentifier,this),this.desiredFeatures=new Set(t.features||[]),this.desiredFeatures.add(w),this.runSoftNavOverSpa=[...this.desiredFeatures].some((e=>e.featureName===a.K7.softNav)),(0,d.j)(this,t,t.loaderType||"agent"),this.run()):(0,e.R)(21)}get config(){return{info:this.info,init:this.init,loader_config:this.loader_config,runtime:this.runtime}}run(){try{const t=u(this.agentIdentifier),r=[...this.desiredFeatures];r.sort(((e,t)=>a.P3[e.featureName]-a.P3[t.featureName])),r.forEach((r=>{if(!t[r.featureName]&&r.featureName!==a.K7.pageViewEvent)return;if(this.runSoftNavOverSpa&&r.featureName===a.K7.spa)return;if(!this.runSoftNavOverSpa&&r.featureName===a.K7.softNav)return;const n=function(e){switch(e){case a.K7.ajax:return[a.K7.jserrors];case a.K7.sessionTrace:return[a.K7.ajax,a.K7.pageViewEvent];case a.K7.sessionReplay:return[a.K7.sessionTrace];case a.K7.pageViewTiming:return[a.K7.pageViewEvent];default:return[]}}(r.featureName).filter((e=>!(e in this.features)));n.length>0&&(0,e.R)(36,{targetFeature:r.featureName,missingDependencies:n}),this.features[r.featureName]=new r(this)}))}catch(t){(0,e.R)(22,t);for(const e in this.features)this.features[e].abortHandler?.();const r=(0,R.Zm)();delete r.initializedAgents[this.agentIdentifier]?.api,delete r.initializedAgents[this.agentIdentifier]?.features,delete this.sharedAggregator;return r.ee.get(this.agentIdentifier).abort(),!1}}}({features:[he,w,N,Ne,_e,_,D,ot,ct,je,nt],loaderType:"spa"})})()})();</script> <meta name="viewport" content="width=device-width, initial-scale=1" /> <link rel="preload" href="https://www.nobelprize.org/wp-content/themes/nobelprize/assets/fonts/ivar/AlfredSerifText-Regular.woff2" as="font" type="font/woff2" crossorigin="anonymous"> <link rel="preload" href="https://www.nobelprize.org/wp-content/themes/nobelprize/assets/fonts/alfred/AlfredSans-Regular.woff2" as="font" type="font/woff2" crossorigin="anonymous"> <link rel="profile" href="http://gmpg.org/xfn/11"> <script>(function(html){html.className = html.className.replace(/\bno-js\b/,'js')})(document.documentElement);</script> <meta name='robots' content='index, follow, max-image-preview:large, max-snippet:-1, max-video-preview:-1' />  <title>Facts on the Nobel Prizes in Physiology or Medicine - NobelPrize.org</title> <meta property="og:locale" content="en_US" /> <meta property="og:type" content="website" /> <meta property="og:site_name" content="NobelPrize.org" /> <meta name="twitter:card" content="summary_large_image" /> <script type="application/ld+json" class="yoast-schema-graph">{"@context":"https://schema.org","@graph":[{"@type":"WebSite","@id":"https://www.nobelprize.org/#website","url":"https://www.nobelprize.org/","name":"NobelPrize.org","description":"The official website of the Nobel Prize","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https://www.nobelprize.org/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"}]}</script>  <link rel='dns-prefetch' href='//www.nobelprize.org' /> <link rel='dns-prefetch' href='//stats.wp.com' /> <link rel='stylesheet' id='mediaelement-css' href='https://www.nobelprize.org/wp-includes/js/mediaelement/mediaelementplayer-legacy.min.css?ver=4.2.17' type='text/css' media='all' /> <link rel='stylesheet' id='wp-mediaelement-css' href='https://www.nobelprize.org/wp-includes/js/mediaelement/wp-mediaelement.min.css?ver=6.6.2' type='text/css' media='all' /> <style id='jetpack-sharing-buttons-style-inline-css' type='text/css'> .jetpack-sharing-buttons__services-list{display:flex;flex-direction:row;flex-wrap:wrap;gap:0;list-style-type:none;margin:5px;padding:0}.jetpack-sharing-buttons__services-list.has-small-icon-size{font-size:12px}.jetpack-sharing-buttons__services-list.has-normal-icon-size{font-size:16px}.jetpack-sharing-buttons__services-list.has-large-icon-size{font-size:24px}.jetpack-sharing-buttons__services-list.has-huge-icon-size{font-size:36px}@media print{.jetpack-sharing-buttons__services-list{display:none!important}}.editor-styles-wrapper .wp-block-jetpack-sharing-buttons{gap:0;padding-inline-start:0}ul.jetpack-sharing-buttons__services-list.has-background{padding:1.25em 2.375em} </style> <style id='global-styles-inline-css' type='text/css'> :root{--wp--preset--aspect-ratio--square: 1;--wp--preset--aspect-ratio--4-3: 4/3;--wp--preset--aspect-ratio--3-4: 3/4;--wp--preset--aspect-ratio--3-2: 3/2;--wp--preset--aspect-ratio--2-3: 2/3;--wp--preset--aspect-ratio--16-9: 16/9;--wp--preset--aspect-ratio--9-16: 9/16;--wp--preset--color--black: #2e2a25;--wp--preset--color--cyan-bluish-gray: #abb8c3;--wp--preset--color--white: #ffffff;--wp--preset--color--pale-pink: #f78da7;--wp--preset--color--vivid-red: #cf2e2e;--wp--preset--color--luminous-vivid-orange: #ff6900;--wp--preset--color--luminous-vivid-amber: #fcb900;--wp--preset--color--light-green-cyan: #7bdcb5;--wp--preset--color--vivid-green-cyan: #00d084;--wp--preset--color--pale-cyan-blue: #8ed1fc;--wp--preset--color--vivid-cyan-blue: #0693e3;--wp--preset--color--vivid-purple: #9b51e0;--wp--preset--color--black-400: #969492;--wp--preset--color--grey-500: #8a8a8d;--wp--preset--color--grey-400: #c8c8c8;--wp--preset--color--grey-100: #f1f1f1;--wp--preset--color--nobel-gold: #cc9b40;--wp--preset--color--nobel-pale: #f2f0ee;--wp--preset--color--nobel-smoke: #f9f5ed;--wp--preset--color--blue-700: #004b87;--wp--preset--color--blue-500: #3880c3;--wp--preset--color--blue-400: #a0c5d8;--wp--preset--color--blue-300: #c2ced9;--wp--preset--color--blue-100: #ebf2f8;--wp--preset--color--red: #bc1836;--wp--preset--color--green-100: #eaefed;--wp--preset--gradient--vivid-cyan-blue-to-vivid-purple: linear-gradient(135deg,rgba(6,147,227,1) 0%,rgb(155,81,224) 100%);--wp--preset--gradient--light-green-cyan-to-vivid-green-cyan: linear-gradient(135deg,rgb(122,220,180) 0%,rgb(0,208,130) 100%);--wp--preset--gradient--luminous-vivid-amber-to-luminous-vivid-orange: linear-gradient(135deg,rgba(252,185,0,1) 0%,rgba(255,105,0,1) 100%);--wp--preset--gradient--luminous-vivid-orange-to-vivid-red: linear-gradient(135deg,rgba(255,105,0,1) 0%,rgb(207,46,46) 100%);--wp--preset--gradient--very-light-gray-to-cyan-bluish-gray: linear-gradient(135deg,rgb(238,238,238) 0%,rgb(169,184,195) 100%);--wp--preset--gradient--cool-to-warm-spectrum: linear-gradient(135deg,rgb(74,234,220) 0%,rgb(151,120,209) 20%,rgb(207,42,186) 40%,rgb(238,44,130) 60%,rgb(251,105,98) 80%,rgb(254,248,76) 100%);--wp--preset--gradient--blush-light-purple: linear-gradient(135deg,rgb(255,206,236) 0%,rgb(152,150,240) 100%);--wp--preset--gradient--blush-bordeaux: linear-gradient(135deg,rgb(254,205,165) 0%,rgb(254,45,45) 50%,rgb(107,0,62) 100%);--wp--preset--gradient--luminous-dusk: linear-gradient(135deg,rgb(255,203,112) 0%,rgb(199,81,192) 50%,rgb(65,88,208) 100%);--wp--preset--gradient--pale-ocean: linear-gradient(135deg,rgb(255,245,203) 0%,rgb(182,227,212) 50%,rgb(51,167,181) 100%);--wp--preset--gradient--electric-grass: linear-gradient(135deg,rgb(202,248,128) 0%,rgb(113,206,126) 100%);--wp--preset--gradient--midnight: linear-gradient(135deg,rgb(2,3,129) 0%,rgb(40,116,252) 100%);--wp--preset--font-size--small: 13px;--wp--preset--font-size--medium: clamp(14px, 0.875rem + ((1vw - 3.2px) * 0.682), 20px);--wp--preset--font-size--large: clamp(22.041px, 1.378rem + ((1vw - 3.2px) * 1.586), 36px);--wp--preset--font-size--x-large: clamp(25.014px, 1.563rem + ((1vw - 3.2px) * 1.93), 42px);--wp--preset--font-size--14: 0.875rem;--wp--preset--font-size--15: clamp(0.875rem, 0.875rem + ((1vw - 0.2rem) * 0.115), 0.938rem);--wp--preset--font-size--16: clamp(0.875rem, 0.875rem + ((1vw - 0.2rem) * 0.227), 1rem);--wp--preset--font-size--18: clamp(0.875rem, 0.875rem + ((1vw - 0.2rem) * 0.455), 1.125rem);--wp--preset--font-size--22: clamp(0.915rem, 0.915rem + ((1vw - 0.2rem) * 0.836), 1.375rem);--wp--preset--font-size--24: clamp(0.984rem, 0.984rem + ((1vw - 0.2rem) * 0.938), 1.5rem);--wp--preset--font-size--32: clamp(1.5rem, 1.5rem + ((1vw - 0.2rem) * 0.909), 2rem);--wp--preset--font-size--48: clamp(2rem, 2rem + ((1vw - 0.2rem) * 1.818), 3rem);--wp--preset--font-size--100: clamp(4rem, 4rem + ((1vw - 0.2rem) * 4.091), 6.25rem);--wp--preset--font-family--primary: 'Alfred Sans Regular', 'Helvetica Neue', 'Arial', sans-serif;--wp--preset--font-family--secondary: 'Alfred Serif Regular', 'Times', 'Times New Roman', serif;--wp--preset--spacing--20: 0.5rem;--wp--preset--spacing--30: 1rem;--wp--preset--spacing--40: 1.25rem;--wp--preset--spacing--50: 1.5rem;--wp--preset--spacing--60: 2rem;--wp--preset--spacing--70: 2.5rem;--wp--preset--spacing--80: 3rem;--wp--preset--spacing--10: 0.25rem;--wp--preset--spacing--90: 3.5rem;--wp--preset--spacing--100: 4rem;--wp--preset--spacing--110: 4.5rem;--wp--preset--spacing--120: 5rem;--wp--preset--spacing--130: 5.5rem;--wp--preset--spacing--140: 6rem;--wp--preset--spacing--150: 6.5rem;--wp--preset--spacing--160: 7rem;--wp--preset--shadow--natural: 6px 6px 9px rgba(0, 0, 0, 0.2);--wp--preset--shadow--deep: 12px 12px 50px rgba(0, 0, 0, 0.4);--wp--preset--shadow--sharp: 6px 6px 0px rgba(0, 0, 0, 0.2);--wp--preset--shadow--outlined: 6px 6px 0px -3px rgba(255, 255, 255, 1), 6px 6px rgba(0, 0, 0, 1);--wp--preset--shadow--crisp: 6px 6px 0px rgba(0, 0, 0, 1);--wp--custom--image-ratio--regular: 3/2;--wp--custom--image-ratio--landscape: 16/9;--wp--custom--image-ratio--portrait: 2/3;--wp--custom--line-height--xs: 1;--wp--custom--line-height--s: 1.125;--wp--custom--line-height--sm: 1.25;--wp--custom--line-height--m: 1.3;--wp--custom--line-height--l: 1.4;--wp--custom--line-height--xl: 1.5;--wp--custom--font-variant--heading--1--font-size: var(--wp--preset--font-size--48);--wp--custom--font-variant--heading--1--line-height: var(--wp--custom--line-height--xs);--wp--custom--font-variant--heading--1--font-family: var(--wp--preset--font-family--primary);--wp--custom--font-variant--heading--2--font-size: var(--wp--preset--font-size--32);--wp--custom--font-variant--heading--2--line-height: var(--wp--custom--line-height--s);--wp--custom--font-variant--heading--2--font-family: var(--wp--preset--font-family--primary);--wp--custom--font-variant--heading--3--font-size: var(--wp--preset--font-size--24);--wp--custom--font-variant--heading--3--line-height: var(--wp--custom--line-height--s);--wp--custom--font-variant--heading--3--font-family: var(--wp--preset--font-family--primary);--wp--custom--font-variant--heading--4--font-size: var(--wp--preset--font-size--18);--wp--custom--font-variant--heading--4--line-height: var(--wp--custom--line-height--sm);--wp--custom--font-variant--heading--4--font-family: var(--wp--preset--font-family--primary);--wp--custom--font-variant--heading--5--font-size: var(--wp--preset--font-size--16);--wp--custom--font-variant--heading--5--line-height: var(--wp--custom--line-height--m);--wp--custom--font-variant--heading--5--font-family: var(--wp--preset--font-family--primary);--wp--custom--font-variant--heading--6--font-size: var(--wp--preset--font-size--15);--wp--custom--font-variant--heading--6--line-height: var(--wp--custom--line-height--xl);--wp--custom--font-variant--heading--6--font-family: var(--wp--preset--font-family--primary);--wp--custom--font-variant--paragraph--xsmall--font-size: var(--wp--preset--font-size--14);--wp--custom--font-variant--paragraph--xsmall--line-height: var(--wp--custom--line-height--l);--wp--custom--font-variant--paragraph--xsmall--font-family: var(--wp--preset--font-family--secondary);--wp--custom--font-variant--paragraph--small--font-size: var(--wp--preset--font-size--16);--wp--custom--font-variant--paragraph--small--line-height: var(--wp--custom--line-height--l);--wp--custom--font-variant--paragraph--small--font-family: var(--wp--preset--font-family--secondary);--wp--custom--font-variant--paragraph--medium--font-size: var(--wp--preset--font-size--18);--wp--custom--font-variant--paragraph--medium--line-height: var(--wp--custom--line-height--m);--wp--custom--font-variant--paragraph--medium--font-family: var(--wp--preset--font-family--secondary);--wp--custom--font-variant--paragraph--large--font-size: var(--wp--preset--font-size--22);--wp--custom--font-variant--paragraph--large--line-height: var(--wp--custom--line-height--m);--wp--custom--font-variant--paragraph--large--font-family: var(--wp--preset--font-family--secondary);--wp--custom--font-variant--button--small--font-size: var(--wp--preset--font-size--14);--wp--custom--font-variant--button--small--line-height: var(--wp--custom--line-height--sm);--wp--custom--font-variant--button--small--font-family: var(--wp--preset--font-family--primary);--wp--custom--font-variant--button--large--font-size: var(--wp--preset--font-size--16);--wp--custom--font-variant--button--large--line-height: var(--wp--custom--line-height--sm);--wp--custom--font-variant--button--large--font-family: var(--wp--preset--font-family--primary);--wp--custom--font-variant--info--counters--font-size: var(--wp--preset--font-size--100);--wp--custom--font-variant--info--counters--line-height: var(--wp--custom--line-height--xs);--wp--custom--font-variant--info--counters--font-family: var(--wp--preset--font-family--primary);--wp--custom--font-variant--info--legal--font-size: var(--wp--preset--font-size--14);--wp--custom--font-variant--info--legal--line-height: var(--wp--custom--line-height--l);--wp--custom--font-variant--info--legal--font-family: var(--wp--preset--font-family--primary);}.wp-block-nobel-prize-queried-content{--wp--preset--color--grey-100: #f1f1f1;--wp--preset--color--nobel-pale: #f2f0ee;--wp--preset--color--nobel-smoke: #f9f5ed;--wp--preset--color--blue-100: #ebf2f8;--wp--preset--color--green-100: #eaefed;}.has-black-color{color: var(--wp--preset--color--black) !important;}.has-cyan-bluish-gray-color{color: var(--wp--preset--color--cyan-bluish-gray) !important;}.has-white-color{color: var(--wp--preset--color--white) !important;}.has-pale-pink-color{color: var(--wp--preset--color--pale-pink) !important;}.has-vivid-red-color{color: var(--wp--preset--color--vivid-red) !important;}.has-luminous-vivid-orange-color{color: var(--wp--preset--color--luminous-vivid-orange) !important;}.has-luminous-vivid-amber-color{color: var(--wp--preset--color--luminous-vivid-amber) !important;}.has-light-green-cyan-color{color: var(--wp--preset--color--light-green-cyan) !important;}.has-vivid-green-cyan-color{color: var(--wp--preset--color--vivid-green-cyan) !important;}.has-pale-cyan-blue-color{color: var(--wp--preset--color--pale-cyan-blue) !important;}.has-vivid-cyan-blue-color{color: var(--wp--preset--color--vivid-cyan-blue) !important;}.has-vivid-purple-color{color: var(--wp--preset--color--vivid-purple) !important;}.has-black-400-color{color: var(--wp--preset--color--black-400) !important;}.has-grey-500-color{color: var(--wp--preset--color--grey-500) !important;}.has-grey-400-color{color: var(--wp--preset--color--grey-400) !important;}.has-grey-100-color{color: var(--wp--preset--color--grey-100) !important;}.has-nobel-gold-color{color: var(--wp--preset--color--nobel-gold) !important;}.has-nobel-pale-color{color: var(--wp--preset--color--nobel-pale) !important;}.has-nobel-smoke-color{color: var(--wp--preset--color--nobel-smoke) !important;}.has-blue-700-color{color: var(--wp--preset--color--blue-700) !important;}.has-blue-500-color{color: var(--wp--preset--color--blue-500) !important;}.has-blue-400-color{color: var(--wp--preset--color--blue-400) !important;}.has-blue-300-color{color: var(--wp--preset--color--blue-300) !important;}.has-blue-100-color{color: var(--wp--preset--color--blue-100) !important;}.has-red-color{color: var(--wp--preset--color--red) !important;}.has-green-100-color{color: var(--wp--preset--color--green-100) !important;}.has-black-background-color{background-color: var(--wp--preset--color--black) !important;}.has-cyan-bluish-gray-background-color{background-color: var(--wp--preset--color--cyan-bluish-gray) !important;}.has-white-background-color{background-color: var(--wp--preset--color--white) !important;}.has-pale-pink-background-color{background-color: var(--wp--preset--color--pale-pink) !important;}.has-vivid-red-background-color{background-color: var(--wp--preset--color--vivid-red) !important;}.has-luminous-vivid-orange-background-color{background-color: var(--wp--preset--color--luminous-vivid-orange) !important;}.has-luminous-vivid-amber-background-color{background-color: var(--wp--preset--color--luminous-vivid-amber) !important;}.has-light-green-cyan-background-color{background-color: var(--wp--preset--color--light-green-cyan) !important;}.has-vivid-green-cyan-background-color{background-color: var(--wp--preset--color--vivid-green-cyan) !important;}.has-pale-cyan-blue-background-color{background-color: var(--wp--preset--color--pale-cyan-blue) !important;}.has-vivid-cyan-blue-background-color{background-color: var(--wp--preset--color--vivid-cyan-blue) !important;}.has-vivid-purple-background-color{background-color: var(--wp--preset--color--vivid-purple) !important;}.has-black-400-background-color{background-color: var(--wp--preset--color--black-400) !important;}.has-grey-500-background-color{background-color: var(--wp--preset--color--grey-500) !important;}.has-grey-400-background-color{background-color: var(--wp--preset--color--grey-400) !important;}.has-grey-100-background-color{background-color: var(--wp--preset--color--grey-100) !important;}.has-nobel-gold-background-color{background-color: var(--wp--preset--color--nobel-gold) !important;}.has-nobel-pale-background-color{background-color: var(--wp--preset--color--nobel-pale) !important;}.has-nobel-smoke-background-color{background-color: var(--wp--preset--color--nobel-smoke) !important;}.has-blue-700-background-color{background-color: var(--wp--preset--color--blue-700) !important;}.has-blue-500-background-color{background-color: var(--wp--preset--color--blue-500) !important;}.has-blue-400-background-color{background-color: var(--wp--preset--color--blue-400) !important;}.has-blue-300-background-color{background-color: var(--wp--preset--color--blue-300) !important;}.has-blue-100-background-color{background-color: var(--wp--preset--color--blue-100) !important;}.has-red-background-color{background-color: var(--wp--preset--color--red) !important;}.has-green-100-background-color{background-color: var(--wp--preset--color--green-100) !important;}.has-black-border-color{border-color: var(--wp--preset--color--black) !important;}.has-cyan-bluish-gray-border-color{border-color: var(--wp--preset--color--cyan-bluish-gray) !important;}.has-white-border-color{border-color: var(--wp--preset--color--white) !important;}.has-pale-pink-border-color{border-color: var(--wp--preset--color--pale-pink) !important;}.has-vivid-red-border-color{border-color: var(--wp--preset--color--vivid-red) !important;}.has-luminous-vivid-orange-border-color{border-color: var(--wp--preset--color--luminous-vivid-orange) !important;}.has-luminous-vivid-amber-border-color{border-color: var(--wp--preset--color--luminous-vivid-amber) !important;}.has-light-green-cyan-border-color{border-color: var(--wp--preset--color--light-green-cyan) !important;}.has-vivid-green-cyan-border-color{border-color: var(--wp--preset--color--vivid-green-cyan) !important;}.has-pale-cyan-blue-border-color{border-color: var(--wp--preset--color--pale-cyan-blue) !important;}.has-vivid-cyan-blue-border-color{border-color: var(--wp--preset--color--vivid-cyan-blue) !important;}.has-vivid-purple-border-color{border-color: var(--wp--preset--color--vivid-purple) !important;}.has-black-400-border-color{border-color: var(--wp--preset--color--black-400) !important;}.has-grey-500-border-color{border-color: var(--wp--preset--color--grey-500) !important;}.has-grey-400-border-color{border-color: var(--wp--preset--color--grey-400) !important;}.has-grey-100-border-color{border-color: var(--wp--preset--color--grey-100) !important;}.has-nobel-gold-border-color{border-color: var(--wp--preset--color--nobel-gold) !important;}.has-nobel-pale-border-color{border-color: var(--wp--preset--color--nobel-pale) !important;}.has-nobel-smoke-border-color{border-color: var(--wp--preset--color--nobel-smoke) !important;}.has-blue-700-border-color{border-color: var(--wp--preset--color--blue-700) !important;}.has-blue-500-border-color{border-color: var(--wp--preset--color--blue-500) !important;}.has-blue-400-border-color{border-color: var(--wp--preset--color--blue-400) !important;}.has-blue-300-border-color{border-color: var(--wp--preset--color--blue-300) !important;}.has-blue-100-border-color{border-color: var(--wp--preset--color--blue-100) !important;}.has-red-border-color{border-color: var(--wp--preset--color--red) !important;}.has-green-100-border-color{border-color: var(--wp--preset--color--green-100) !important;}.has-vivid-cyan-blue-to-vivid-purple-gradient-background{background: var(--wp--preset--gradient--vivid-cyan-blue-to-vivid-purple) !important;}.has-light-green-cyan-to-vivid-green-cyan-gradient-background{background: var(--wp--preset--gradient--light-green-cyan-to-vivid-green-cyan) !important;}.has-luminous-vivid-amber-to-luminous-vivid-orange-gradient-background{background: var(--wp--preset--gradient--luminous-vivid-amber-to-luminous-vivid-orange) !important;}.has-luminous-vivid-orange-to-vivid-red-gradient-background{background: var(--wp--preset--gradient--luminous-vivid-orange-to-vivid-red) !important;}.has-very-light-gray-to-cyan-bluish-gray-gradient-background{background: var(--wp--preset--gradient--very-light-gray-to-cyan-bluish-gray) !important;}.has-cool-to-warm-spectrum-gradient-background{background: var(--wp--preset--gradient--cool-to-warm-spectrum) !important;}.has-blush-light-purple-gradient-background{background: var(--wp--preset--gradient--blush-light-purple) !important;}.has-blush-bordeaux-gradient-background{background: var(--wp--preset--gradient--blush-bordeaux) !important;}.has-luminous-dusk-gradient-background{background: var(--wp--preset--gradient--luminous-dusk) !important;}.has-pale-ocean-gradient-background{background: var(--wp--preset--gradient--pale-ocean) !important;}.has-electric-grass-gradient-background{background: var(--wp--preset--gradient--electric-grass) !important;}.has-midnight-gradient-background{background: var(--wp--preset--gradient--midnight) !important;}.has-small-font-size{font-size: var(--wp--preset--font-size--small) !important;}.has-medium-font-size{font-size: var(--wp--preset--font-size--medium) !important;}.has-large-font-size{font-size: var(--wp--preset--font-size--large) !important;}.has-x-large-font-size{font-size: var(--wp--preset--font-size--x-large) !important;}.has-14-font-size{font-size: var(--wp--preset--font-size--14) !important;}.has-15-font-size{font-size: var(--wp--preset--font-size--15) !important;}.has-16-font-size{font-size: var(--wp--preset--font-size--16) !important;}.has-18-font-size{font-size: var(--wp--preset--font-size--18) !important;}.has-22-font-size{font-size: var(--wp--preset--font-size--22) !important;}.has-24-font-size{font-size: var(--wp--preset--font-size--24) !important;}.has-32-font-size{font-size: var(--wp--preset--font-size--32) !important;}.has-48-font-size{font-size: var(--wp--preset--font-size--48) !important;}.has-100-font-size{font-size: var(--wp--preset--font-size--100) !important;}.has-primary-font-family{font-family: var(--wp--preset--font-family--primary) !important;}.has-secondary-font-family{font-family: var(--wp--preset--font-family--secondary) !important;}.wp-block-nobel-prize-queried-content.has-grey-100-color{color: var(--wp--preset--color--grey-100) !important;}.wp-block-nobel-prize-queried-content.has-nobel-pale-color{color: var(--wp--preset--color--nobel-pale) !important;}.wp-block-nobel-prize-queried-content.has-nobel-smoke-color{color: var(--wp--preset--color--nobel-smoke) !important;}.wp-block-nobel-prize-queried-content.has-blue-100-color{color: var(--wp--preset--color--blue-100) !important;}.wp-block-nobel-prize-queried-content.has-green-100-color{color: var(--wp--preset--color--green-100) !important;}.wp-block-nobel-prize-queried-content.has-grey-100-background-color{background-color: var(--wp--preset--color--grey-100) !important;}.wp-block-nobel-prize-queried-content.has-nobel-pale-background-color{background-color: var(--wp--preset--color--nobel-pale) !important;}.wp-block-nobel-prize-queried-content.has-nobel-smoke-background-color{background-color: var(--wp--preset--color--nobel-smoke) !important;}.wp-block-nobel-prize-queried-content.has-blue-100-background-color{background-color: var(--wp--preset--color--blue-100) !important;}.wp-block-nobel-prize-queried-content.has-green-100-background-color{background-color: var(--wp--preset--color--green-100) !important;}.wp-block-nobel-prize-queried-content.has-grey-100-border-color{border-color: var(--wp--preset--color--grey-100) !important;}.wp-block-nobel-prize-queried-content.has-nobel-pale-border-color{border-color: var(--wp--preset--color--nobel-pale) !important;}.wp-block-nobel-prize-queried-content.has-nobel-smoke-border-color{border-color: var(--wp--preset--color--nobel-smoke) !important;}.wp-block-nobel-prize-queried-content.has-blue-100-border-color{border-color: var(--wp--preset--color--blue-100) !important;}.wp-block-nobel-prize-queried-content.has-green-100-border-color{border-color: var(--wp--preset--color--green-100) !important;} :where(.wp-block-post-template.is-layout-flex){gap: 1.25em;}:where(.wp-block-post-template.is-layout-grid){gap: 1.25em;} :where(.wp-block-columns.is-layout-flex){gap: 2em;}:where(.wp-block-columns.is-layout-grid){gap: 2em;} :root :where(.wp-block-pullquote){font-size: clamp(0.984em, 0.984rem + ((1vw - 0.2em) * 0.938), 1.5em);line-height: 1.6;} </style> <link rel='stylesheet' id='nobelprize_block_library_admin-css' href='https://www.nobelprize.org/wp-content/plugins/nobelprize-block-library/dist/css/frontend.css?ver=9af3caa4ba4635a79486' type='text/css' media='all' /> <link rel='stylesheet' id='styles-css' href='https://www.nobelprize.org/wp-content/themes/nobelprize/dist/css/frontend.css?ver=0fc4ea04d626abf846ed' type='text/css' media='all' /> <script type="text/javascript" id="loadjs-js-extra"> /* <![CDATA[ */ var fallback = {"path":"\/var\/www\/html\/wp-content\/themes\/nobelprize\/\/assets\/js\/frontend\/lib\/respimg\/ls.respimg.min.js"}; /* ]]> */ </script> <script type="text/javascript" src="https://www.nobelprize.org/wp-content/themes/nobelprize/assets/js/frontend/lib/loadjs.js?ver=1732293022" id="loadjs-js"></script> <style>img#wpstats{display:none}</style> <link type="text/plain" rel="author" href="https://www.nobelprize.org/wp-content/themes/nobelprize/humans.txt" /> <script> window.VIDEOJS_NO_BASE_THEME = true; window.VIDEOJS_NO_DYNAMIC_STYLE = true; </script>  <script type="text/javascript" src="https://cdn.cookielaw.org/consent/d75760b8-7732-445e-9a87-2de3e237d0fe/OtAutoBlock.js"></script> <script src="https://cdn.cookielaw.org/scripttemplates/otSDKStub.js" type="text/javascript" charset="UTF-8" data-domain-script="d75760b8-7732-445e-9a87-2de3e237d0fe"></script> <script type="text/javascript"> function OptanonWrapper() { } </script>   <script type="text/javascript">(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer','GTM-WDHZ8W5');</script>   <meta name="twitter:title" content="Facts on the Nobel Prize in Physiology or Medicine"> <meta itemprop="name" content="Facts on the Nobel Prize in Physiology or Medicine" /> <meta property="og:title" content="Facts on the Nobel Prize in Physiology or Medicine" />   <meta name="twitter:description" content="Facts on the Nobel Prize in Physiology or Medicine"> <meta itemprop="description" content="Facts on the Nobel Prize in Physiology or Medicine" /> <meta property="og:description" content="Facts on the Nobel Prize in Physiology or Medicine" />   <meta name="twitter:card" content="summary_large_image" /> <meta name="twitter:image" content="https://www.nobelprize.org/images/52950-content-landscape-tablet.jpg" /> <meta itemprop="image" content="https://www.nobelprize.org/images/52950-content-landscape-tablet.jpg" /> <meta property="og:image" content="https://www.nobelprize.org/images/52950-content-landscape-tablet.jpg" />  <meta property="og:url" content="https://www.nobelprize.org/prizes/facts/facts-on-the-nobel-prize-in-physiology-or-medicine" /> <link rel="icon" href="https://www.nobelprize.org/uploads/2018/08/Nobel-favicon-50x50.png" sizes="32x32" /> <link rel="icon" href="https://www.nobelprize.org/uploads/2018/08/Nobel-favicon-232x232.png" sizes="192x192" /> <link rel="apple-touch-icon" href="https://www.nobelprize.org/uploads/2018/08/Nobel-favicon-188x188.png" /> <meta name="msapplication-TileImage" content="https://www.nobelprize.org/uploads/2018/08/Nobel-favicon.png" /> <style type="text/css" id="wp-custom-css"> .summit-event-nav .prizes-nav-top-tier li:last-of-type { border-right: 0; } .ot-sdk-show-settings:hover, .ot-sdk-show-settings { background-color: #CEA152 !important; border-color: #CEA152 !important; color: #FFFFFF !important; } </style> </head> <body class="prize-content">  <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-WDHZ8W5" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>   <a class="skip-link screen-reader-text" href="#content"> Skip to content </a> <header class="site-header js-site-header" role="banner" itemscope="itemscope" itemtype="http://schema.org/WPHeader"> <div class="site-header__wrapper container"> <div class="site-banner" itemscope itemtype="http://schema.org/Organization"> <div class="site-banner-logo" itemscope itemtype="http://schema.org/Organization"> <h1 class="site-logo" itemprop="logo"> <a itemprop="url" href="https://www.nobelprize.org" name="top" aria-label="The Nobel Prize"> <svg class="site-logo-icon site-logo-icon--big" xmlns="http://www.w3.org/2000/svg" width="77" height="60" fill="none" viewBox="0 0 77 60"><path d="M25.298 1.997h-4.631v14.66h-2.21V1.997h-4.674V0h11.515v1.997ZM42.126 0v16.657h-2.21V8.711h-9.179v7.946h-2.21V0h2.21v6.714h9.179V0h2.21Zm14.617 16.657V14.66h-7.691V8.711h7.011V6.714h-7.011V1.997h7.564V0h-9.731v16.657h9.858Zm-43.045 5.014V38.33h-1.53L2.225 25.41v12.918H.1V21.67h1.7l9.773 12.578V21.671h2.125Zm12.025-.34c-4.801 0-8.71 3.867-8.71 8.669 0 4.802 3.909 8.669 8.71 8.669 4.802 0 8.711-3.867 8.711-8.669 0-4.802-3.91-8.669-8.71-8.669Zm.043 2.083c3.527 0 6.459 2.932 6.459 6.586 0 3.654-2.932 6.586-6.46 6.586-3.526 0-6.458-2.932-6.458-6.586 0-3.654 2.932-6.586 6.459-6.586Zm23.116 9.943c0 2.932-2.125 4.972-5.227 4.972h-5.779V21.67h5.27c3.059 0 4.971 1.53 4.971 3.995 0 1.614-.85 2.89-2.252 3.527 1.87.68 3.017 2.167 3.017 4.164Zm-8.796-9.73v4.8h3.06c1.53 0 2.846-.934 2.846-2.506 0-1.573-1.232-2.295-2.847-2.295h-3.06Zm6.629 9.772c0-1.87-1.445-3.017-3.145-3.017h-3.484v6.034h3.484c1.7-.042 3.145-1.147 3.145-3.017Zm15.467 4.93V36.33h-7.649v-5.949h7.012v-1.997h-7.012V23.67h7.564V21.67h-9.773V38.33h9.858ZM76.29 36.33v1.998h-9.731V21.67h2.21v14.66h7.52Zm-65.057 15.85c2.89 0 4.93-1.784 4.93-4.419 0-2.592-2.04-4.42-4.972-4.42H5.41V60h2.21v-7.819h3.612Zm0-6.841c1.615 0 2.72.892 2.72 2.422 0 1.53-1.105 2.422-2.72 2.422H7.621V45.34h3.612Zm12.11 6.756h-1.742V60h-2.21V43.343h5.78c2.89 0 4.929 1.742 4.929 4.376 0 2.423-1.742 4.08-4.25 4.335l6.035 7.904H29.25l-5.906-7.862ZM21.602 50.1h3.612c1.657 0 2.72-.85 2.72-2.38 0-1.53-1.105-2.38-2.72-2.38h-3.612v4.76Zm15.17-6.756h-2.21V60h2.21V43.343Zm3.442 14.915L49.86 45.34h-8.71v-1.997h11.557v1.614l-9.73 13.046h9.985V60H40.213v-1.742ZM66.304 60v-1.997h-7.691v-5.95h7.011v-1.996h-7.011V45.34h7.564v-1.997h-9.731V60h9.858Z"/></svg> <svg class="site-logo-icon site-logo-icon--small" xmlns="http://www.w3.org/2000/svg" width="171" height="16" fill="none" viewBox="0 0 171 16"><path d="M10.3 2.222H6.256v12.684H4.344V2.222H.3V.494h9.963v1.728h.037ZM24.822.494v14.412H22.91V8.03h-7.94v6.875h-1.913V.494h1.912v5.809h7.941V.494h1.912Zm12.61 12.684v1.728h-8.53V.494h8.42v1.728h-6.544v4.081h6.066v1.728h-6.066v5.147h6.654ZM57.322.494v14.412h-1.324L47.397 3.729v11.177h-1.839V.494h1.47l8.457 10.883V.494h1.838ZM60.19 7.7c0-4.154 3.382-7.5 7.537-7.5 4.154 0 7.536 3.346 7.536 7.5s-3.382 7.5-7.537 7.5c-4.154 0-7.536-3.346-7.536-7.5Zm13.162 0c0-3.162-2.537-5.699-5.589-5.699-3.051 0-5.588 2.537-5.588 5.699s2.537 5.699 5.588 5.699c3.052 0 5.588-2.537 5.588-5.699Zm14.411 2.904c0 2.537-1.838 4.302-4.522 4.302h-5.037V.494h4.56c2.646 0 4.3 1.324 4.3 3.456 0 1.397-.735 2.5-1.948 3.051 1.655.589 2.647 1.875 2.647 3.603Zm-7.61-8.419V6.34H82.8c1.324 0 2.463-.81 2.463-2.17 0-1.36-1.066-1.985-2.463-1.985h-2.647Zm5.735 8.456c0-1.617-1.25-2.61-2.72-2.61h-3.015v5.22h3.015c1.47-.036 2.72-.992 2.72-2.61Zm13.383 2.537v1.728h-8.53V.494h8.42v1.728h-6.545v4.081h6.103v1.728h-6.066v5.147h6.618Zm12.206 0v1.728h-8.42V.494h1.912v12.684h6.508Zm15.514-8.86c0 2.28-1.765 3.823-4.265 3.823h-3.125v6.765h-1.911V.494h5c2.537 0 4.301 1.581 4.301 3.824Zm-1.912 0c0-1.324-.955-2.096-2.353-2.096h-3.125v4.191h3.125c1.398 0 2.353-.772 2.353-2.095Zm8.089 3.75h-1.508v6.838h-1.911V.494h5c2.5 0 4.264 1.507 4.264 3.787 0 2.095-1.507 3.53-3.676 3.75l5.22 6.838h-2.279l-5.11-6.801Zm-1.471-1.728h3.125c1.434 0 2.353-.736 2.353-2.06 0-1.323-.956-2.058-2.353-2.058h-3.125V6.34ZM142.91.494h1.912v14.412h-1.912V.494ZM147.8 13.4l8.346-11.177h-7.537V.494h10v1.397l-8.419 11.287h8.639v1.728H147.8v-1.508Zm22.537-.221v1.728h-8.53V.494h8.42v1.728h-6.545v4.081h6.067v1.728h-6.067v5.147h6.655Z"/></svg> </a> </h1> </div> <div class="mobile-actions"> <div class="mobile-search"> <button type="button" id="search-mobile-trigger-js" aria-controls="header-search-form" aria-expanded="false"> <svg class="search-open" xmlns="http://www.w3.org/2000/svg" width="24" height="24" viewBox="0 0 24 24" fill="none" role="img" aria-labelledby="desktop-search-title"> <title id="desktop-search-title">Open the search menu</title> <path fill="#2E2A25" d="m19.6 21-6.3-6.3A6.096 6.096 0 0 1 9.5 16c-1.817 0-3.354-.63-4.612-1.887C3.629 12.854 3 11.317 3 9.5c0-1.817.63-3.354 1.888-4.612C6.146 3.629 7.683 3 9.5 3c1.817 0 3.354.63 4.613 1.888C15.37 6.146 16 7.683 16 9.5a6.096 6.096 0 0 1-1.3 3.8l6.3 6.3-1.4 1.4ZM9.5 14c1.25 0 2.313-.438 3.188-1.313C13.562 11.813 14 10.75 14 9.5c0-1.25-.438-2.313-1.313-3.188C11.813 5.438 10.75 5 9.5 5c-1.25 0-2.313.438-3.188 1.313S5 8.25 5 9.5c0 1.25.438 2.313 1.313 3.188C7.188 13.562 8.25 14 9.5 14Z"/> </svg> <svg class="search-close" xmlns="http://www.w3.org/2000/svg" width="24" height="24" fill="#2E2A25" role="img" aria-labelledby="desktop-search-title"> <title id="desktop-search-title">Close the search menu</title> <path d="M6.4 19 5 17.6l5.6-5.6L5 6.4 6.4 5l5.6 5.6L17.6 5 19 6.4 13.4 12l5.6 5.6-1.4 1.4-5.6-5.6L6.4 19Z"/> </svg> </button>  <noscript> <a id="mobile-close-js" class="toggle-close" href="#"> <span>Close Mobile Menu</span> </a> </noscript> </div> <div class="mobile-nav"> <button type="button" id="mobile-nav-js" class="toggle" aria-controls="main-navigation-js" aria-expanded="false"> <span> Toggle Mobile Menu </span> </button> </div> </div> </div> <nav id="main-navigation-js" class="site-main-navigation" role="navigation" itemscope="itemscope" itemtype="http://schema.org/SiteNavigationElement" aria-label="Main menu" aria-hidden="true"> <ul id="menu-header_top" class="main-menu" role="menu"><li id="menu-item-28259" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-has-children menu-item-28259" role="menuitem"><a href="/prizes/">Nobel Prizes & laureates</a> <ul class="sub-menu" role="menu" aria-hidden="true"> <li id="menu-item-175174" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-175174" role="menuitem"><a href="/prizes/lists/all-nobel-prizes/">All Nobel Prizes</a></li> <li id="menu-item-222451" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-222451" role="menuitem"><a href="https://www.nobelprize.org/all-nobel-prizes-2024/">All Nobel Prizes 2024</a></li> <li id="menu-item-48853" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-48853" role="menuitem"><a href="/prizes/physics/">Physics prize</a></li> <li id="menu-item-48854" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-48854" role="menuitem"><a href="/prizes/chemistry/">Chemistry prize</a></li> <li id="menu-item-48855" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-48855" role="menuitem"><a href="/prizes/medicine/">Medicine prize</a></li> <li id="menu-item-48856" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-48856" role="menuitem"><a href="/prizes/literature/">Literature prize</a></li> <li id="menu-item-48857" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-48857" role="menuitem"><a href="/prizes/peace/">Peace prize</a></li> <li id="menu-item-48858" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-48858" role="menuitem"><a href="/prizes/economic-sciences/">Prize in economic sciences</a></li> </ul> </li> <li id="menu-item-28260" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-has-children menu-item-28260" role="menuitem"><a href="/about/">About</a> <ul class="sub-menu" role="menu" aria-hidden="true"> <li id="menu-item-43405" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-43405" role="menuitem"><a href="/about-the-nobel-prize/">About the prize</a></li> <li id="menu-item-43408" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-43408" role="menuitem"><a href="/alfred-nobel">Alfred Nobel</a></li> <li id="menu-item-43407" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-43407" role="menuitem"><a href="/about/nobel-prize-award-ceremonies/">Award ceremonies</a></li> <li id="menu-item-43409" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-43409" role="menuitem"><a href="/nomination">Nomination</a></li> <li id="menu-item-43406" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-43406" role="menuitem"><a href="/the-nobel-prize-organisation">Organisation</a></li> </ul> </li> <li id="menu-item-28261" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-28261" role="menuitem"><a href="/stories/">Stories</a></li> <li id="menu-item-28262" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-28262" role="menuitem"><a href="/educational/">Educational</a></li> <li id="menu-item-219562" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-219562" role="menuitem"><a href="/events-museums/">Events & museums</a></li> <li role="menuitem" class="searchform"> <button type="button" id="search-trigger-js" aria-controls="header-search-form" aria-expanded="false"> <svg class="search-open" xmlns="http://www.w3.org/2000/svg" width="24" height="24" viewbox="0 0 24 24" fill="none" role="img" aria-labelledby="desktop-search-title"> <title id="desktop-search-title">Open the search menu</title> <path fill="#2E2A25" d="m19.6 21-6.3-6.3A6.096 6.096 0 0 1 9.5 16c-1.817 0-3.354-.63-4.612-1.887C3.629 12.854 3 11.317 3 9.5c0-1.817.63-3.354 1.888-4.612C6.146 3.629 7.683 3 9.5 3c1.817 0 3.354.63 4.613 1.888C15.37 6.146 16 7.683 16 9.5a6.096 6.096 0 0 1-1.3 3.8l6.3 6.3-1.4 1.4ZM9.5 14c1.25 0 2.313-.438 3.188-1.313C13.562 11.813 14 10.75 14 9.5c0-1.25-.438-2.313-1.313-3.188C11.813 5.438 10.75 5 9.5 5c-1.25 0-2.313.438-3.188 1.313S5 8.25 5 9.5c0 1.25.438 2.313 1.313 3.188C7.188 13.562 8.25 14 9.5 14Z"></path> </svg> <svg class="search-close" xmlns="http://www.w3.org/2000/svg" width="24" height="24" fill="#2E2A25" role="img" aria-labelledby="desktop-search-title"> <title id="desktop-search-title">Close the search menu</title> <path d="M6.4 19 5 17.6l5.6-5.6L5 6.4 6.4 5l5.6 5.6L17.6 5 19 6.4 13.4 12l5.6 5.6-1.4 1.4-5.6-5.6L6.4 19Z"></path> </svg> </button> </li> </ul> </nav> </div> <div id="header-search-form" class="header-search-form js-header-search-form" aria-hidden="true"> <div class="container"> <form class="searchform -header" method="GET" action="/search/" > <label for="search-form-input-header" class="screen-reader-text"> Header Search </label> <input type="search" class="input" name="s" id="search-form-input-header" placeholder="Enter your search here" value="" required> <button type="submit"> <svg width="24" height="24" viewBox="0 0 24 24" xmlns="http://www.w3.org/2000/svg" fill="#2E2A25" role="img" aria-labelledby="submit-search-title-header -header"> <title id="submit-search-title-header">Submit a search term</title> <path d="m19.6 21-6.3-6.3A6.096 6.096 0 0 1 9.5 16c-1.817 0-3.354-.63-4.612-1.887C3.629 12.854 3 11.317 3 9.5c0-1.817.63-3.354 1.888-4.612C6.146 3.629 7.683 3 9.5 3c1.817 0 3.354.63 4.613 1.888C15.37 6.146 16 7.683 16 9.5a6.096 6.096 0 0 1-1.3 3.8l6.3 6.3-1.4 1.4ZM9.5 14c1.25 0 2.313-.438 3.188-1.313C13.562 11.813 14 10.75 14 9.5c0-1.25-.438-2.313-1.313-3.188C11.813 5.438 10.75 5 9.5 5c-1.25 0-2.313.438-3.188 1.313S5 8.25 5 9.5c0 1.25.438 2.313 1.313 3.188C7.188 13.562 8.25 14 9.5 14Z"/> </svg> </button> </form> </div> </div> </header> <main id="content" role="main" class="nobel-content"> <section class="page-hero -exposed page-hero__variation--d context-post -color-option-default"> <div class="bg hero lazyload" data-bgset="https://www.nobelprize.org/images/52950-hero-tablet-2x.jpg [(min-width: 220px)] | https://www.nobelprize.org/images/52950-hero-tablet-2x.jpg [(min-width: 900px)] | https://www.nobelprize.org/images/52950-hero-desktop-2x.jpg [(min-width: 1400px)]" data-sizes="auto"> </div> <noscript> <div class="bg hero" style="background: url(https://www.nobelprize.org/images/52950-content-landscape-desktop.jpg)" > </div> </noscript> <div class="figcaption"> <p class="figcaption__caption"> 1945 Medicine Laureate Sir. Alexander Fleming was awarded the prize because of his discovery of penicillin </p> <p class="figcaption__attribution"> © Nobel Media. Photo: Alexander Mahmoud </p> </div> <h1 class="title "> Facts on the Nobel Prize in Physiology or Medicine </h1> </section> <section class="page-section"> <section class="page-content border-top"> <article class=" entry entry-gutenberg"> <p class="ingress">On 27 November 1895, Alfred Nobel signed his last will and testament, giving the largest share of his fortune to a series of prizes, the Nobel Prizes. As described in Nobel’s will, one part was dedicated to “the person who shall have made the most important discovery within the domain of physiology or medicine”. Learn more about the Nobel Prize in Physiology or Medicine from 1901 to 2024.</p> <h2 class="wp-block-heading">Number of Nobel Prizes in Physiology or Medicine</h2> <p><strong>115</strong><b> </b>Nobel Prizes in Physiology or Medicine have been awarded since 1901. It was not awarded on nine occasions: in 1915, 1916, 1917, 1918, 1921, 1925, 1940, 1941 and 1942.</p> <p>Why were the medicine prizes not awarded in those years? In the statutes of the Nobel Foundation it says: “If none of the works under consideration is found to be of the importance indicated in the first paragraph, the prize money shall be reserved until the following year. If, even then, the prize cannot be awarded, the amount shall be added to the Foundation’s restricted funds.” During World War I and II, fewer Nobel Prizes were awarded.</p> <h2 class="wp-block-heading">Shared and unshared Nobel Prizes in Physiology or Medicine</h2> <p>40 medicine prizes have been given to one laureate* only.<br />36 medicine prizes have been shared by two laureates.<br />39 medicine prizes have been shared between three laureates.</p> <p>Why is that? In the statutes of the Nobel Foundation it says: A prize amount may be equally divided between two works, each of which is considered to merit a prize. If a work that is being rewarded has been produced by two or three persons, the prize shall be awarded to them jointly. In no case may a prize amount be divided between more than three persons.</p> <h2 class="wp-block-heading">Number of Nobel Prize laureates in physiology or medicine</h2> <p><strong>229</strong> individuals have been awarded 1901-2024.</p> <p><a class="text_link" href="https://www.nobelprize.org/prizes/lists/all-nobel-laureates-in-physiology-or-medicine/">List of all Nobel Prize laureates in physiology or medicinene</a></p> <h2 class="wp-block-heading">Youngest medicine laureate</h2> <div class="dynamic-list"> <div class="card-prize"> <h3> <a href="https://www.nobelprize.org/prizes/medicine/1923/summary/"> The Nobel Prize in Physiology or Medicine 1923 </a> </h3> <div class="card-prize--laureates"> <div class="card-prize--laureates --one"> <div class="card-prize--laureates--links --has-age"> <a class="card-prize--laureates--links--link" href="https://www.nobelprize.org/prizes/medicine/1923/banting/facts/"> Frederick G. Banting</a> <div class="card-prize--laureates--links--age"> Awarded at age 31 </div> </div> <blockquote class="card-prize--laureates--motivation --last "> “for the discovery of insulin” </blockquote> </div> </div> </div> <input type="hidden" class="dynamic-list-current-page" value="1"/> <input type="hidden" class="dynamic-list-attributes" value="{"category":"med","gender":"all","hasAffiliation":false,"decadePagination":false,"startYear":"","endYear":"","orderBy":"age","order":"ASC","show_age":true,"is_list_ordered_by_age":true,"is_gender_filtered_list":false}"/> <input type="hidden" class="dynamic-list-rest-url" value="/wp-json/nobelprize/v1/dynamic-list-load-more"/> </div> <h2 class="wp-block-heading">Oldest medicine laureate</h2> <div class="dynamic-list"> <div class="card-prize"> <h3> <a href="https://www.nobelprize.org/prizes/medicine/1966/summary/"> The Nobel Prize in Physiology or Medicine 1966 </a> </h3> <div class="card-prize--laureates"> <div class="card-prize--laureates --one"> <div class="card-prize--laureates--links --has-age"> <a class="card-prize--laureates--links--link" href="https://www.nobelprize.org/prizes/medicine/1966/rous/facts/"> Peyton Rous</a> <div class="card-prize--laureates--links--age"> Awarded at age 87 </div> </div> <blockquote class="card-prize--laureates--motivation --last "> “for his discovery of tumour-inducing viruses” </blockquote> </div> </div> </div> <input type="hidden" class="dynamic-list-current-page" value="1"/> <input type="hidden" class="dynamic-list-attributes" value="{"category":"med","gender":"all","hasAffiliation":false,"decadePagination":false,"startYear":"","endYear":"","orderBy":"age","order":"DESC","show_age":true,"is_list_ordered_by_age":true,"is_gender_filtered_list":false}"/> <input type="hidden" class="dynamic-list-rest-url" value="/wp-json/nobelprize/v1/dynamic-list-load-more"/> </div> <h2 class="wp-block-heading">Female Nobel Prize laureates in physiology or medicine</h2> <p>Of the 229 individuals awarded the Nobel Prize in Physiology or Medicine, 13 are women. Of these 13, Barabara McClintock is the only one who has received an unshared Nobel Prize.</p> <div class="dynamic-list"> <div class="card-prize"> <h3> <a href="https://www.nobelprize.org/prizes/medicine/1947/summary/"> The Nobel Prize in Physiology or Medicine 1947 </a> </h3> <div class="card-prize--laureates"> <div class="card-prize--laureates --one"> <div class="card-prize--laureates--links "> <a class="card-prize--laureates--links--link" href="https://www.nobelprize.org/prizes/medicine/1947/cori-gt/facts/"> Gerty Cori</a> </div> <blockquote class="card-prize--laureates--motivation --last "> “for their discovery of the course of the catalytic conversion of glycogen” </blockquote> </div> </div> </div> <div class="card-prize"> <h3> <a href="https://www.nobelprize.org/prizes/medicine/1977/summary/"> The Nobel Prize in Physiology or Medicine 1977 </a> </h3> <div class="card-prize--laureates"> <div class="card-prize--laureates --one"> <div class="card-prize--laureates--links "> <a class="card-prize--laureates--links--link" href="https://www.nobelprize.org/prizes/medicine/1977/yalow/facts/"> Rosalyn Yalow</a> </div> <blockquote class="card-prize--laureates--motivation --last "> “for the development of radioimmunoassays of peptide hormones” </blockquote> </div> </div> </div> <div class="card-prize"> <h3> <a href="https://www.nobelprize.org/prizes/medicine/1983/summary/"> The Nobel Prize in Physiology or Medicine 1983 </a> </h3> <div class="card-prize--laureates"> <div class="card-prize--laureates --one"> <div class="card-prize--laureates--links "> <a class="card-prize--laureates--links--link" href="https://www.nobelprize.org/prizes/medicine/1983/mcclintock/facts/"> Barbara McClintock</a> </div> <blockquote class="card-prize--laureates--motivation --last "> “for her discovery of mobile genetic elements” </blockquote> </div> </div> </div> <div class="card-prize"> <h3> <a href="https://www.nobelprize.org/prizes/medicine/1986/summary/"> The Nobel Prize in Physiology or Medicine 1986 </a> </h3> <div class="card-prize--laureates"> <div class="card-prize--laureates --one"> <div class="card-prize--laureates--links "> <a class="card-prize--laureates--links--link" href="https://www.nobelprize.org/prizes/medicine/1986/levi-montalcini/facts/"> Rita Levi-Montalcini</a> </div> <blockquote class="card-prize--laureates--motivation --last "> “for their discoveries of growth factors” </blockquote> </div> </div> </div> <div class="card-prize"> <h3> <a href="https://www.nobelprize.org/prizes/medicine/1988/summary/"> The Nobel Prize in Physiology or Medicine 1988 </a> </h3> <div class="card-prize--laureates"> <div class="card-prize--laureates --one"> <div class="card-prize--laureates--links "> <a class="card-prize--laureates--links--link" href="https://www.nobelprize.org/prizes/medicine/1988/elion/facts/"> Gertrude B. Elion</a> </div> <blockquote class="card-prize--laureates--motivation --last "> “for their discoveries of important principles for drug treatment” </blockquote> </div> </div> </div> <div class="card-prize"> <h3> <a href="https://www.nobelprize.org/prizes/medicine/1995/summary/"> The Nobel Prize in Physiology or Medicine 1995 </a> </h3> <div class="card-prize--laureates"> <div class="card-prize--laureates --one"> <div class="card-prize--laureates--links "> <a class="card-prize--laureates--links--link" href="https://www.nobelprize.org/prizes/medicine/1995/nusslein-volhard/facts/"> Christiane Nüsslein-Volhard</a> </div> <blockquote class="card-prize--laureates--motivation --last "> “for their discoveries concerning the genetic control of early embryonic development” </blockquote> </div> </div> </div> <div class="card-prize"> <h3> <a href="https://www.nobelprize.org/prizes/medicine/2004/summary/"> The Nobel Prize in Physiology or Medicine 2004 </a> </h3> <div class="card-prize--laureates"> <div class="card-prize--laureates --one"> <div class="card-prize--laureates--links "> <a class="card-prize--laureates--links--link" href="https://www.nobelprize.org/prizes/medicine/2004/buck/facts/"> Linda B. Buck</a> </div> <blockquote class="card-prize--laureates--motivation --last "> “for their discoveries of odorant receptors and the organization of the olfactory system” </blockquote> </div> </div> </div> <div class="card-prize"> <h3> <a href="https://www.nobelprize.org/prizes/medicine/2008/summary/"> The Nobel Prize in Physiology or Medicine 2008 </a> </h3> <div class="card-prize--laureates"> <div class="card-prize--laureates --one"> <div class="card-prize--laureates--links "> <a class="card-prize--laureates--links--link" href="https://www.nobelprize.org/prizes/medicine/2008/barre-sinoussi/facts/"> Françoise Barré-Sinoussi</a> </div> <blockquote class="card-prize--laureates--motivation --last "> “for their discovery of human immunodeficiency virus” </blockquote> </div> </div> </div> <div class="card-prize"> <h3> <a href="https://www.nobelprize.org/prizes/medicine/2009/summary/"> The Nobel Prize in Physiology or Medicine 2009 </a> </h3> <div class="card-prize--laureates"> <div class="card-prize--laureates --one"> <div class="card-prize--laureates--links "> <a class="card-prize--laureates--links--link" href="https://www.nobelprize.org/prizes/medicine/2009/blackburn/facts/"> Elizabeth H. Blackburn</a> </div> <blockquote class="card-prize--laureates--motivation "> “for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase” </blockquote> </div> <div class="card-prize--laureates --one"> <div class="card-prize--laureates--links "> <a class="card-prize--laureates--links--link" href="https://www.nobelprize.org/prizes/medicine/2009/greider/facts/"> Carol W. Greider</a> </div> <blockquote class="card-prize--laureates--motivation --last "> “for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase” </blockquote> </div> </div> </div> <div class="card-prize"> <h3> <a href="https://www.nobelprize.org/prizes/medicine/2014/summary/"> The Nobel Prize in Physiology or Medicine 2014 </a> </h3> <div class="card-prize--laureates"> <div class="card-prize--laureates --one"> <div class="card-prize--laureates--links "> <a class="card-prize--laureates--links--link" href="https://www.nobelprize.org/prizes/medicine/2014/may-britt-moser/facts/"> May-Britt Moser</a> </div> <blockquote class="card-prize--laureates--motivation --last "> “for their discoveries of cells that constitute a positioning system in the brain” </blockquote> </div> </div> </div> <div class="card-prize"> <h3> <a href="https://www.nobelprize.org/prizes/medicine/2015/summary/"> The Nobel Prize in Physiology or Medicine 2015 </a> </h3> <div class="card-prize--laureates"> <div class="card-prize--laureates --one"> <div class="card-prize--laureates--links "> <a class="card-prize--laureates--links--link" href="https://www.nobelprize.org/prizes/medicine/2015/tu/facts/"> Tu Youyou</a> </div> <blockquote class="card-prize--laureates--motivation --last "> “for her discoveries concerning a novel therapy against Malaria” </blockquote> </div> </div> </div> <div class="card-prize"> <h3> <a href="https://www.nobelprize.org/prizes/medicine/2023/summary/"> The Nobel Prize in Physiology or Medicine 2023 </a> </h3> <div class="card-prize--laureates"> <div class="card-prize--laureates --one"> <div class="card-prize--laureates--links "> <a class="card-prize--laureates--links--link" href="https://www.nobelprize.org/prizes/medicine/2023/kariko/facts/"> Katalin Karikó</a> </div> <blockquote class="card-prize--laureates--motivation --last "> “for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19” </blockquote> </div> </div> </div> <input type="hidden" class="dynamic-list-current-page" value="1"/> <input type="hidden" class="dynamic-list-attributes" value="{"category":"med","gender":"female","hasAffiliation":false,"decadePagination":false,"startYear":"2024","endYear":"","orderBy":"year","order":"ASC","show_age":false,"is_list_ordered_by_age":false,"is_gender_filtered_list":true}"/> <input type="hidden" class="dynamic-list-rest-url" value="/wp-json/nobelprize/v1/dynamic-list-load-more"/> </div> <p><a class="text_link" href="https://www.nobelprize.org/prizes/lists/nobel-prize-awarded-women/">List of all female Nobel Prize laureates</a></p> <h2 class="wp-block-heading">Multiple Nobel Prize laureates in physiology or medicine</h2> <p>No one has been awarded the Nobel Prize in Physiology or Medicine more than once. Yet …</p> <p><a class="text_link" href="/nobel_prizes/facts/index.html#multiple">List of multiple Nobel Prize laureates within other prize categories</a></p> <h2 class="wp-block-heading">Posthumous Nobel Prizes in Physiology or Medicine</h2> <p>There have been no posthumous Nobel Prizes in Chemistry. From 1974, the <a href="https://www.nobelprize.org/about/statutes-of-the-nobel-foundation/">Statutes </a>of the Nobel Foundation stipulate that a Nobel Prize cannot be awarded posthumously, unless death has occurred after the announcement of the Nobel Prize. Before 1974, the Nobel Prize has only been awarded posthumously twice: to <a href="https://www.nobelprize.org/prizes/peace/1961/hammarskjold/facts/">Dag Hammarskjöld </a> (Nobel Peace Prize 1961) and <a href="https://www.nobelprize.org/prizes/literature/1931/karlfeldt/facts/">Erik Axel Karlfeldt </a> (Nobel Prize in Literature 1931).</p> <p>Following the 2011 announcement of the Nobel Prize in Physiology or Medicine, it was discovered that one of the medicine laureates, Ralph Steinman, had passed away three days earlier. The Board of the Nobel Foundation examined the statutes, and an interpretation of the purpose of the rule above lead to the conclusion that Ralph Steinman should to remain a Nobel Prize laureate, as the Nobel Assembly at Karolinska Institutet had announced the 2011 Nobel Prize laureates in physiology or medicine without knowing of his death.</p> <h2 class="wp-block-heading">Family Nobel Prize laureates in physiology or medicine</h2> <section class="most-popular-laureates"> <header class="section-header border-top"> <h3> Married couples </h3> </header> <article class="laureate border-top" itemscope itemtype="http://schema.org/Person"> <figure class="content-img"> <a href="/prizes/medicine/1947/cori-gt/"> <picture ><source data-srcset="https://www.nobelprize.org/images/cori-gt-13052-portrait-mini-2x.jpg" media="(min-width: 220px)" /><source data-srcset="https://www.nobelprize.org/images/cori-gt-13052-portrait-small-2x.jpg" media="(min-width: 900px)" /><source data-srcset="https://www.nobelprize.org/images/cori-gt-13052-portrait-medium-2x.jpg" media="(min-width: 1400px)" /><img class="lazyload" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" alt="Gerty Theresa Cori, née Radnitz" /><noscript><img src="https://www.nobelprize.org/images/cori-gt-13052-portrait-medium.jpg" alt="Gerty Theresa Cori, née Radnitz" /></noscript></picture> </a> </figure> <div class="content"> <h4 itemprop="name"> <a href="/prizes/medicine/1947/cori-gt/" title="Gerty Theresa Cori, née Radnitz" itemprop="url"> Gerty Theresa Cori, née Radnitz </a> </h4> <span> <a href="/prizes/medicine/1947/cori-gt/"> The Nobel Prize in Physiology or Medicine 1947 </a> </span> <q itemscope itemtype="http://schema.org/Quotation">for their discovery of the course of the catalytic conversion of glycogen.</q> </div> </article> <article class="laureate border-top" itemscope itemtype="http://schema.org/Person"> <figure class="content-img"> <a href="/prizes/medicine/1947/cori-cf/"> <picture ><source data-srcset="https://www.nobelprize.org/images/cori-cf-13051-portrait-mini-2x.jpg" media="(min-width: 220px)" /><source data-srcset="https://www.nobelprize.org/images/cori-cf-13051-portrait-small-2x.jpg" media="(min-width: 900px)" /><source data-srcset="https://www.nobelprize.org/images/cori-cf-13051-portrait-medium-2x.jpg" media="(min-width: 1400px)" /><img class="lazyload" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" alt="Carl Ferdinand Cori" /><noscript><img src="https://www.nobelprize.org/images/cori-cf-13051-portrait-medium.jpg" alt="Carl Ferdinand Cori" /></noscript></picture> </a> </figure> <div class="content"> <h4 itemprop="name"> <a href="/prizes/medicine/1947/cori-cf/" title="Carl Ferdinand Cori" itemprop="url"> Carl Ferdinand Cori </a> </h4> <span> <a href="/prizes/medicine/1947/cori-cf/"> The Nobel Prize in Physiology or Medicine 1947 </a> </span> <q itemscope itemtype="http://schema.org/Quotation">for their discovery of the course of the catalytic conversion of glycogen.</q> </div> </article> <article class="laureate border-top" itemscope itemtype="http://schema.org/Person"> <figure class="content-img"> <a href="/prizes/medicine/2014/may-britt-moser/"> <picture ><source data-srcset="https://www.nobelprize.org/images/may-britt-moser-15191-portrait-mini-2x.jpg" media="(min-width: 220px)" /><source data-srcset="https://www.nobelprize.org/images/may-britt-moser-15191-portrait-small-2x.jpg" media="(min-width: 900px)" /><source data-srcset="https://www.nobelprize.org/images/may-britt-moser-15191-portrait-medium-2x.jpg" media="(min-width: 1400px)" /><img class="lazyload" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" alt="May-Britt Moser" /><noscript><img src="https://www.nobelprize.org/images/may-britt-moser-15191-portrait-medium.jpg" alt="May-Britt Moser" /></noscript></picture> </a> </figure> <div class="content"> <h4 itemprop="name"> <a href="/prizes/medicine/2014/may-britt-moser/" title="May-Britt Moser" itemprop="url"> May-Britt Moser </a> </h4> <span> <a href="/prizes/medicine/2014/may-britt-moser/"> The Nobel Prize in Physiology or Medicine 2014 </a> </span> <q itemscope itemtype="http://schema.org/Quotation">for their discoveries of cells that constitute a positioning system in the brain.</q> </div> </article> <article class="laureate border-top" itemscope itemtype="http://schema.org/Person"> <figure class="content-img"> <a href="/prizes/medicine/2014/edvard-moser/"> <picture ><source data-srcset="https://www.nobelprize.org/images/edvard-moser-15192-portrait-mini-2x.jpg" media="(min-width: 220px)" /><source data-srcset="https://www.nobelprize.org/images/edvard-moser-15192-portrait-small-2x.jpg" media="(min-width: 900px)" /><source data-srcset="https://www.nobelprize.org/images/edvard-moser-15192-portrait-medium-2x.jpg" media="(min-width: 1400px)" /><img class="lazyload" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" alt="Edvard I. Moser" /><noscript><img src="https://www.nobelprize.org/images/edvard-moser-15192-portrait-medium.jpg" alt="Edvard I. Moser" /></noscript></picture> </a> </figure> <div class="content"> <h4 itemprop="name"> <a href="/prizes/medicine/2014/edvard-moser/" title="Edvard I. Moser" itemprop="url"> Edvard I. Moser </a> </h4> <span> <a href="/prizes/medicine/2014/edvard-moser/"> The Nobel Prize in Physiology or Medicine 2014 </a> </span> <q itemscope itemtype="http://schema.org/Quotation">for their discoveries of cells that constitute a positioning system in the brain.</q> </div> </article> </section> <section class="most-popular-laureates"> <header class="section-header border-top"> <h3> Father & son </h3> </header> <article class="laureate border-top" itemscope itemtype="http://schema.org/Person"> <figure class="content-img"> <a href="/prizes/chemistry/1929/euler-chelpin/"> <picture ><source data-srcset="https://www.nobelprize.org/images/euler-chelpin-12961-portrait-mini-2x.jpg" media="(min-width: 220px)" /><source data-srcset="https://www.nobelprize.org/images/euler-chelpin-12961-portrait-small-2x.jpg" media="(min-width: 900px)" /><source data-srcset="https://www.nobelprize.org/images/euler-chelpin-12961-portrait-medium-2x.jpg" media="(min-width: 1400px)" /><img class="lazyload" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" alt="Hans Karl August Simon von Euler-Chelpin" /><noscript><img src="https://www.nobelprize.org/images/euler-chelpin-12961-portrait-medium.jpg" alt="Hans Karl August Simon von Euler-Chelpin" /></noscript></picture> </a> </figure> <div class="content"> <h4 itemprop="name"> <a href="/prizes/chemistry/1929/euler-chelpin/" title="Hans Karl August Simon von Euler-Chelpin" itemprop="url"> Hans Karl August Simon von Euler-Chelpin </a> </h4> <span> <a href="/prizes/chemistry/1929/euler-chelpin/"> The Nobel Prize in Chemistry 1929 </a> </span> <q itemscope itemtype="http://schema.org/Quotation">for their investigations on the fermentation of sugar and fermentative enzymes.</q> </div> </article> <article class="laureate border-top" itemscope itemtype="http://schema.org/Person"> <figure class="content-img"> <a href="/prizes/medicine/1970/euler/"> <picture ><source data-srcset="https://www.nobelprize.org/images/euler-13221-portrait-mini-2x.jpg" media="(min-width: 220px)" /><source data-srcset="https://www.nobelprize.org/images/euler-13221-portrait-small-2x.jpg" media="(min-width: 900px)" /><source data-srcset="https://www.nobelprize.org/images/euler-13221-portrait-medium-2x.jpg" media="(min-width: 1400px)" /><img class="lazyload" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" alt="Ulf von Euler" /><noscript><img src="https://www.nobelprize.org/images/euler-13221-portrait-medium.jpg" alt="Ulf von Euler" /></noscript></picture> </a> </figure> <div class="content"> <h4 itemprop="name"> <a href="/prizes/medicine/1970/euler/" title="Ulf von Euler" itemprop="url"> Ulf von Euler </a> </h4> <span> <a href="/prizes/medicine/1970/euler/"> The Nobel Prize in Physiology or Medicine 1970 </a> </span> <q itemscope itemtype="http://schema.org/Quotation">for their discoveries concerning the humoral transmitters in the nerve terminals and the mechanism for their storage, release and inactivation.</q> </div> </article> <article class="laureate border-top" itemscope itemtype="http://schema.org/Person"> <figure class="content-img"> <a href="/prizes/medicine/1982/bergstrom/"> <picture ><source data-srcset="https://www.nobelprize.org/images/bergstrom-13346-portrait-mini-2x.jpg" media="(min-width: 220px)" /><source data-srcset="https://www.nobelprize.org/images/bergstrom-13346-portrait-small-2x.jpg" media="(min-width: 900px)" /><source data-srcset="https://www.nobelprize.org/images/bergstrom-13346-portrait-medium-2x.jpg" media="(min-width: 1400px)" /><img class="lazyload" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" alt="Sune K. Bergström" /><noscript><img src="https://www.nobelprize.org/images/bergstrom-13346-portrait-medium.jpg" alt="Sune K. Bergström" /></noscript></picture> </a> </figure> <div class="content"> <h4 itemprop="name"> <a href="/prizes/medicine/1982/bergstrom/" title="Sune K. Bergström" itemprop="url"> Sune K. Bergström </a> </h4> <span> <a href="/prizes/medicine/1982/bergstrom/"> The Nobel Prize in Physiology or Medicine 1982 </a> </span> <q itemscope itemtype="http://schema.org/Quotation">for their discoveries concerning prostaglandins and related biologically active substances.</q> </div> </article> <article class="laureate border-top" itemscope itemtype="http://schema.org/Person"> <figure class="content-img"> <a href="/prizes/medicine/2022/paabo/"> <picture ><source data-srcset="https://www.nobelprize.org/images/143954-portrait-mini-2x.jpg" media="(min-width: 220px)" /><source data-srcset="https://www.nobelprize.org/images/143954-portrait-small-2x.jpg" media="(min-width: 900px)" /><source data-srcset="https://www.nobelprize.org/images/143954-portrait-medium-2x.jpg" media="(min-width: 1400px)" /><img class="lazyload" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" alt="Svante Pääbo" /><noscript><img src="https://www.nobelprize.org/images/143954-portrait-medium.jpg" alt="Svante Pääbo" /></noscript></picture> </a> </figure> <div class="content"> <h4 itemprop="name"> <a href="/prizes/medicine/2022/paabo/" title="Svante Pääbo" itemprop="url"> Svante Pääbo </a> </h4> <span> <a href="/prizes/medicine/2022/paabo/"> The Nobel Prize in Physiology or Medicine 2022 </a> </span> <q itemscope itemtype="http://schema.org/Quotation">for his discoveries concerning the genomes of extinct hominins and human evolution.</q> </div> </article> </section> <section class="most-popular-laureates"> <header class="section-header border-top"> <h3> Brothers </h3> </header> <article class="laureate border-top" itemscope itemtype="http://schema.org/Person"> <figure class="content-img"> <a href="/prizes/economic-sciences/1969/tinbergen/"> <picture ><source data-srcset="https://www.nobelprize.org/images/tinbergen-13210-portrait-mini-2x.jpg" media="(min-width: 220px)" /><source data-srcset="https://www.nobelprize.org/images/tinbergen-13210-portrait-small-2x.jpg" media="(min-width: 900px)" /><source data-srcset="https://www.nobelprize.org/images/tinbergen-13210-portrait-medium-2x.jpg" media="(min-width: 1400px)" /><img class="lazyload" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" alt="Jan Tinbergen" /><noscript><img src="https://www.nobelprize.org/images/tinbergen-13210-portrait-medium.jpg" alt="Jan Tinbergen" /></noscript></picture> </a> </figure> <div class="content"> <h4 itemprop="name"> <a href="/prizes/economic-sciences/1969/tinbergen/" title="Jan Tinbergen" itemprop="url"> Jan Tinbergen </a> </h4> <span> <a href="/prizes/economic-sciences/1969/tinbergen/"> The Sveriges Riksbank Prize in Economic Sciences in Memory of Alfred Nobel 1969 </a> </span> <q itemscope itemtype="http://schema.org/Quotation">for having developed and applied dynamic models for the analysis of economic processes.</q> </div> </article> <article class="laureate border-top" itemscope itemtype="http://schema.org/Person"> <figure class="content-img"> <a href="/prizes/medicine/1973/tinbergen/"> <picture ><source data-srcset="https://www.nobelprize.org/images/tinbergen-13249-portrait-mini-2x.jpg" media="(min-width: 220px)" /><source data-srcset="https://www.nobelprize.org/images/tinbergen-13249-portrait-small-2x.jpg" media="(min-width: 900px)" /><source data-srcset="https://www.nobelprize.org/images/tinbergen-13249-portrait-medium-2x.jpg" media="(min-width: 1400px)" /><img class="lazyload" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" alt="Nikolaas Tinbergen" /><noscript><img src="https://www.nobelprize.org/images/tinbergen-13249-portrait-medium.jpg" alt="Nikolaas Tinbergen" /></noscript></picture> </a> </figure> <div class="content"> <h4 itemprop="name"> <a href="/prizes/medicine/1973/tinbergen/" title="Nikolaas Tinbergen" itemprop="url"> Nikolaas Tinbergen </a> </h4> <span> <a href="/prizes/medicine/1973/tinbergen/"> The Nobel Prize in Physiology or Medicine 1973 </a> </span> <q itemscope itemtype="http://schema.org/Quotation">for their discoveries concerning organization and elicitation of individual and social behaviour patterns.</q> </div> </article> </section> <h2 class="wp-block-heading">Forced to decline the Nobel Prize</h2> <p>Two Nobel Prize laureates in chemistry have been forced by authorities to decline the Nobel Prize. Adolf Hitler forbade three German Nobel Prize laureates from receiving the Nobel Prize – two of whom were awarded the Nobel Prize in Chemistry, <a href="https://www.nobelprize.org/prizes/chemistry/1938/kuhn/facts/">Richard Kuhn</a> in 1938 and <a href="https://www.nobelprize.org/prizes/chemistry/1939/butenandt/facts/">Adolf Butenandt</a> in 1939. The third person, <a href="https://www.nobelprize.org/prizes/medicine/1939/domagk/facts/">Gerhard Domagk </a>was awarded the Nobel Prize in Physiology or Medicine in 1939. All of them could receive the Nobel Prize diploma and medal later, but not the prize amount.</p> <h2 class="wp-block-heading">Nobel Prize laureate partnerships in biomedical science</h2> <p>Many long scientific partnerships have resulted in Nobel Prizes:</p> <figure class="wp-block-table grey-borders"> <table> <tbody> <tr> <td><em>Partners</em></td> <td><em>Years of<br />Partnership</em></td> <td><em>Dates</em></td> </tr> <tr> <td><a href="/prizes/medicine/1985/brown/facts/">Michael S. Brown</a> & <a href="/prizes/medicine/1985/goldstein/facts/">Joseph L. Goldstein</a></td> <td>40</td> <td>1972-present</td> </tr> <tr> <td><a href="/prizes/medicine/1947/cori-cf/facts/">Carl Cori</a> & <a href="/prizes/medicine/1947/cori-gt/facts/">Gerty Cori</a></td> <td>34</td> <td>1922-56</td> </tr> <tr> <td><a href="/prizes/chemistry/1972/stein/facts/">William H. Stein</a> & <a href="https://www.nobelprize.org/prizes/chemistry/1972/moore/facts/">Stanford Moore</a></td> <td>33</td> <td>1939-72</td> </tr> <tr> <td><a href="/prizes/medicine/1956/cournand/facts/">André F. Cournand</a> & <a href="/prizes/medicine/1956/richards/facts/">Dickinson W. Richards</a></td> <td>30</td> <td>1932-62</td> </tr> <tr> <td><a href="/prizes/medicine/1988/hitchings/facts/">George H. Hitchings</a> & <a href="/prizes/medicine/1988/elion/facts/">Gertrude B. Elion</a></td> <td>23</td> <td>1944-67</td> </tr> <tr> <td><a href="/prizes/medicine/1981/hubel/facts/">David H. Hubel </a>& <a href="/prizes/medicine/1981/wiesel/facts/">Torsten N. Wiesel</a></td> <td>20</td> <td>1958-78</td> </tr> <tr> <td><a href="/prizes/medicine/1989/bishop/facts/">J. Michael Bishop</a> & <a href="/prizes/medicine/1989/varmus/facts/">Harold E. Varmus</a></td> <td>19</td> <td>1971-90</td> </tr> <tr> <td><a href="/prizes/medicine/1950/hench/facts/">Philip S. Hench</a> & <a href="https://www.nobelprize.org/prizes/medicine/1950/kendall/facts/">Edward C. Kendall</a></td> <td>16</td> <td>1934-50</td> </tr> <tr> <td><a href="/prizes/medicine/1992/fischer/facts/">Edmond H. Fischer</a> & <a href="/prizes/medicine/1992/krebs/facts/">Edwin G. Krebs</a></td> <td>11</td> <td>1953-64</td> </tr> <tr> <td><a href="/prizes/medicine/1965/jacob/facts/">François Jacob</a> & <a href="/prizes/medicine/1965/monod/facts/">Jacques Monod</a></td> <td>9</td> <td>1957-66</td> </tr> <tr> <td><a href="/prizes/medicine/1962/watson/facts/">James Watson</a> & <a href="/prizes/medicine/1962/crick/facts/">Francis Crick</a></td> <td>2</td> <td>1951-53</td> </tr> </tbody> </table> </figure> <p>List compiled in 2012, courtesy of Joseph L. Goldstein.</p> <h2 class="wp-block-heading">Nominations for the Nobel Prize in Physiology or Medicine</h2> <p>In the nomination database, you can find interesting nomination trivia, for example, that the Austrian neurologist and founder of psychoanalysis Sigmund Freud (1856-1939) was nominated 32 times for the Nobel Prize in Physiology or Medicine, but never awarded. In 1929, the Nobel Committee for Medicine engaged an expert who concluded that a further investigation in Freud was not necessary, since Freud’s work was of no proven scientific value. Freud was also nominated once for the 1936 Nobel Prize in Literature by Nobel Prize laureate <a href="https://www.nobelprize.org/prizes/literature/1915/rolland/facts/">Romain Rolland</a>, an acquaintance of Freud.</p> <p>The nominations for the Nobel Prizes are kept secret for 50 years.</p> <p><a class="text_link" href="/nomination/archive/">Explore the nomination database for the Nobel Prizes</a></p> <h2 class="wp-block-heading">The Nobel Prize medal in physiology and medicine</h2> <p>The Nobel Prize medal in physiology and medicine was designed by Swedish sculptor and engraver Erik Lindberg and represents the Genius of Medicine holding an open book in her lap, collecting the water pouring out from a rock in order to quench a sick girl’s thirst.</p> <p><a class="text_link" href="https://www.nobelprize.org/prizes/facts/the-nobel-medal-for-physiology-or-medicine/">Read more about Nobel medal in Physiology and Medicine</a></p> <h2 class="wp-block-heading">The Nobel Prize diplomas</h2> <p>Each Nobel Prize diploma is a unique work of art, created by foremost Swedish and Norwegian artists and calligraphers.</p> <p><a class="text_link" href="https://www.nobelprize.org/prizes/about/the-nobel-diplomas">More about the Nobel Prize diplomas</a></p> <h2 class="wp-block-heading">The Nobel Prize amount</h2> <p>Alfred Nobel left most of his estate, more than SEK 31 million (today approximately SEK 2,2 billion) to be converted into a fund and invested in “safe securities.” The income from the investments was to be “distributed annually in the form of prizes to those who during the preceding year have conferred the greatest benefit to humankind.”</p> <p>The Nobel Prize amount for 2024 is set at Swedish kronor (SEK) 11.0 million per full Nobel Prize.</p> <p><a href="https://www.nobelprize.org/prizes/about/the-nobel-prize-amounts/">More about the Nobel Prize amount</a></p> <hr class="wp-block-separator has-alpha-channel-opacity"/> <h3 class="wp-block-heading">*Why “laureate”? </h3> <p>Why are the individuals and organisations awarded a Nobel Prize called Nobel Prize laureate? The word “laureate” refers to being signified by the laurel wreath. In Greek mythology, the god Apollo is represented wearing a laurel wreath on his head. A laurel wreath is a circular Crown made of branches and leaves of the bay laurel (in Latin: <em>Laurus nobilis</em>). In Ancient Greece, laurel wreaths were awarded to victors as a sign of honour – both in athletic competitions and in poetic meets.</p> <hr class="wp-block-separator has-alpha-channel-opacity"/> <h2 class="wp-block-heading">More facts on the Nobel Prizes</h2> <ul class="wp-block-list"> <li><a href="https://www.nobelprize.org/prizes/facts/facts-on-the-nobel-prize-in-physics/">Facts on the Nobel Prize in Physics</a></li> <li><a href="https://www.nobelprize.org/prizes/facts/facts-on-the-nobel-prize-in-chemistry/">Facts on the Nobel Prize in Chemistry</a></li> <li><a href="https://www.nobelprize.org/prizes/facts/facts-on-the-nobel-prize-in-physiology-or-medicine/">Facts on the Nobel Prize in Physiology or Medicine</a></li> <li><a href="https://www.nobelprize.org/prizes/facts/facts-on-the-nobel-prize-in-literature/">Facts on the Nobel Prize in Literature</a></li> <li><a href="https://www.nobelprize.org/prizes/facts/facts-on-the-nobel-peace-prize/">Facts on the Nobel Peace Prize</a></li> <li><a href="https://www.nobelprize.org/prizes/facts/facts-on-the-prize-in-economic-sciences">Facts on the prize in economic sciences</a></li> <li><a href="https://www.nobelprize.org/prizes/facts/nobel-prize-facts/">Facts on all Nobel Prizes</a></li> </ul> <p class="has-15-font-size">First published 5 October 2009.</p> </article> <footer class="border-top pagecite" itemscope itemtype="http://schema.org/citation"> <p> To cite this section <br> MLA style: Facts on the Nobel Prize in Physiology or Medicine. NobelPrize.org. Nobel Prize Outreach AB 2024. Sat. 30 Nov 2024. <https://www.nobelprize.org/prizes/facts/facts-on-the-nobel-prize-in-physiology-or-medicine> </p> </footer> </section> <aside class="page-aside border-top -full-width"> <footer class="footer"> <div class="share-this"> <h6 class="heading"> Share this </h6> <ul class="socialicons" aria-label="Social sharing links"> <li class="socialicon" data-social="facebook"> <a href="https://www.facebook.com/sharer.php?u=https%3A%2F%2Fwww.nobelprize.org%2Fprizes%2Ffacts%2Ffacts-on-the-nobel-prize-in-physiology-or-medicine&t=Facts+on+the+Nobel+Prize+in+Physiology+or+Medicine" data-target="https://www.nobelprize.org/prizes/facts/facts-on-the-nobel-prize-in-physiology-or-medicine" target="_blank" rel="noreferrer" > <svg xmlns="http://www.w3.org/2000/svg" width="40" height="40" viewBox="0 0 40 40"><path d="M14.526 34h-3.96A4.572 4.572 0 0 1 6 29.43V10.57C6 8.051 8.051 6 10.571 6H29.43A4.577 4.577 0 0 1 34 10.57v18.854c0 2.52-2.051 4.57-4.571 4.57h-3.492a.573.573 0 0 1-.571-.571V22.305c0-.314.257-.571.571-.571h2.229l.405-3.228h-2.634a.573.573 0 0 1-.571-.571v-3.28c0-.314.257-.57.571-.57h2.709v-3.229h-4.892a1.62 1.62 0 0 0-1.617 1.617v5.462a.573.573 0 0 1-.571.571h-2.709v3.228h2.709c.314 0 .571.257.571.571v11.118a.59.59 0 0 1-.166.406c-.148.148-.171.171-7.44.171h-.005ZM10.57 7.143a3.43 3.43 0 0 0-3.428 3.427v18.854a3.43 3.43 0 0 0 3.423 3.428h10.423V22.87H18.28a.573.573 0 0 1-.571-.572v-4.37c0-.314.257-.571.571-.571h2.709v-4.89c0-1.52 1.24-2.76 2.76-2.76h5.462c.315 0 .572.257.572.571v4.37a.573.573 0 0 1-.572.572h-2.708v2.137h2.708a.56.56 0 0 1 .429.194c.109.126.16.286.137.451l-.548 4.37a.573.573 0 0 1-.566.504h-2.16v9.975h2.92a3.43 3.43 0 0 0 3.428-3.428V10.57a3.43 3.43 0 0 0-3.428-3.427H10.57Z"/></svg> <span class="screen-reader-text"> Facebook </span> </a> </li> <li class="socialicon" data-social="twitter"> <a href="https://twitter.com/intent/tweet?text=Facts+on+the+Nobel+Prize+in+Physiology+or+Medicine&url=https%3A%2F%2Fwww.nobelprize.org%2Fprizes%2Ffacts%2Ffacts-on-the-nobel-prize-in-physiology-or-medicine" data-target="https://www.nobelprize.org/prizes/facts/facts-on-the-nobel-prize-in-physiology-or-medicine" target="_blank" rel="noreferrer" > <svg xmlns="http://www.w3.org/2000/svg" width="40" height="40" viewBox="0 0 40 40"><path fill-rule="evenodd" d="M11.143 6h17.714A5.148 5.148 0 0 1 34 11.143v17.714A5.148 5.148 0 0 1 28.857 34H11.143A5.148 5.148 0 0 1 6 28.857V11.143A5.148 5.148 0 0 1 11.143 6Zm17.714 26.857c2.205 0 4-1.795 4-4V11.143c0-2.205-1.795-4-4-4H11.143c-2.205 0-4 1.795-4 4v17.714c0 2.205 1.795 4 4 4h17.714Zm-.995-22.384a.572.572 0 0 1 .847.768l-6.933 7.65 6.977 9.923a.572.572 0 0 1-.468.9h-3.714a.571.571 0 0 1-.468-.243l-5.205-7.404-6.76 7.46a.57.57 0 0 1-.808.04.572.572 0 0 1-.04-.808l6.934-7.65-6.977-9.923a.572.572 0 0 1 .468-.9h3.714c.186 0 .36.09.467.243l5.206 7.404 6.76-7.46Zm-15.047.956L24.869 28.57h2.317L15.132 11.43h-2.317Z" clip-rule="evenodd"/></svg> <span class="screen-reader-text"> X </span> </a> </li> <li class="socialicon" data-social="linkedin"> <a href="https://www.linkedin.com/shareArticle?mini=true&url=https%3A%2F%2Fwww.nobelprize.org%2Fprizes%2Ffacts%2Ffacts-on-the-nobel-prize-in-physiology-or-medicine&title=Facts+on+the+Nobel+Prize+in+Physiology+or+Medicine" data-target="https://www.nobelprize.org/prizes/facts/facts-on-the-nobel-prize-in-physiology-or-medicine" target="_blank" rel="noreferrer" > <svg xmlns="http://www.w3.org/2000/svg" width="40" height="40" viewBox="0 0 40 40"><path fill-rule="evenodd" d="M12.909 14.251a2.557 2.557 0 0 1-2.555-2.554 2.56 2.56 0 0 1 2.555-2.554 2.56 2.56 0 0 1 2.554 2.554 2.56 2.56 0 0 1-2.554 2.554Zm0-3.965c-.778 0-1.412.634-1.412 1.411s.634 1.412 1.412 1.412c.777 0 1.411-.635 1.411-1.412 0-.777-.634-1.411-1.411-1.411Z" clip-rule="evenodd"/><path d="M28.771 28.211c0 .315.258.572.572.572l-.006-.006a.573.573 0 0 0 .572-.571v-7.292c0-3.605-2.509-4.891-4.852-4.891-1.457 0-2.497.383-3.44 1v-.532a.573.573 0 0 0-.571-.571h-3.612a.573.573 0 0 0-.571.571v11.715c0 .314.257.571.571.571a.573.573 0 0 0 .572-.571V17.063h2.468v1.108a.574.574 0 0 0 .943.44c1.057-.891 2.034-1.44 3.646-1.44 1.114 0 3.708.366 3.708 3.749v7.291ZM14.611 28.783a.573.573 0 0 1-.571-.572V17.07h-2.543V28.21a.573.573 0 0 1-.571.572.573.573 0 0 1-.572-.572V16.497c0-.314.257-.571.572-.571h3.685c.315 0 .572.257.572.571v11.714a.573.573 0 0 1-.572.572Z"/><path d="M25.657 28.783a.573.573 0 0 1-.571-.572V22.83c0-1.286-.412-1.738-1.577-1.738-1.252 0-1.886.458-1.886 1.355v5.765a.573.573 0 0 1-.572.572.573.573 0 0 1-.571-.572v-5.765c0-1.56 1.131-2.497 3.029-2.497 1.897 0 2.72.971 2.72 2.88v5.382a.573.573 0 0 1-.572.572Z"/><path fill-rule="evenodd" d="M11.143 34h17.714A5.15 5.15 0 0 0 34 28.857V11.143A5.15 5.15 0 0 0 28.857 6H11.143A5.15 5.15 0 0 0 6 11.143v17.714A5.15 5.15 0 0 0 11.143 34Zm-4-22.857c0-2.206 1.794-4 4-4h17.714c2.206 0 4 1.794 4 4v17.714c0 2.206-1.794 4-4 4H11.143c-2.206 0-4-1.794-4-4V11.143Z" clip-rule="evenodd"/></svg> <span class="screen-reader-text"> LinkedIn </span> </a> </li> <li class="socialicon" data-social="email"> <a data-target="https://www.nobelprize.org/prizes/facts/facts-on-the-nobel-prize-in-physiology-or-medicine" href="/cdn-cgi/l/email-protection#e8d79b9d8a828d8b9cd5ae9a8785cddad8a6878a8d84b89a81928dc6879a8fd2cddad8ae898b9c9bcddad88786cddad89c808dcddad8a6878a8d84cddad8b89a81928dcddad88186cddad8b880919b818784878f91cddad8879acddad8a58d8c818b81868dcecbd8dbd0d38a878c91d5809c9c989bd2c7c79f9f9fc686878a8d84989a81928dc6879a8fc7989a81928d9bc78e898b9c9bc78e898b9c9bc58786c59c808dc586878a8d84c5989a81928dc58186c59880919b818784878f91c5879ac5858d8c818b81868d" target="_blank" rel="noreferrer"> <svg xmlns="http://www.w3.org/2000/svg" width="40" height="40" viewBox="0 0 40 40"><path fill-rule="evenodd" d="M12.229 14.02A1.37 1.37 0 0 0 11 15.384v9.84a1.37 1.37 0 0 0 1.37 1.37h15.26a1.37 1.37 0 0 0 1.37-1.37V15.37A1.37 1.37 0 0 0 27.63 14H12.37a.5.5 0 0 0-.141.02Zm.256.98a.504.504 0 0 1-.114.013.37.37 0 0 0-.371.37v9.841a.37.37 0 0 0 .37.37h15.26a.37.37 0 0 0 .37-.37V15.37a.37.37 0 0 0-.37-.37H12.485Zm.288.88a.5.5 0 0 1 .699-.107L20 20.577l6.528-4.804a.5.5 0 0 1 .593.805l-6.825 5.023a.5.5 0 0 1-.592 0l-6.825-5.023a.5.5 0 0 1-.106-.699Z" clip-rule="evenodd"/><path fill-rule="evenodd" d="M28.857 6H11.143A5.148 5.148 0 0 0 6 11.143v17.714A5.148 5.148 0 0 0 11.143 34h17.714A5.148 5.148 0 0 0 34 28.857V11.143A5.148 5.148 0 0 0 28.857 6Zm4 22.857c0 2.205-1.795 4-4 4H11.143c-2.205 0-4-1.795-4-4V11.143c0-2.205 1.795-4 4-4h17.714c2.205 0 4 1.795 4 4v17.714Z" clip-rule="evenodd"/></svg> <span class="screen-reader-text"> Email this page </span> </a> </li> </ul> </div> </footer> </aside> </section> </main> <footer class="site-footer" role="contentinfo"> <div class="container"> <section class="footer-information"> <h4 class="heading"> <a href="/the-nobel-prize-organisation/">About the Nobel Prize organisation</a> </h4> <div class="footer-sections"> <div class="footer-section"> <h5> <a href="/the-nobel-prize-organisation/the-nobel-foundation/">The Nobel Foundation</a> </h5> <p>Tasked with a mission to manage Alfred Nobel's fortune and has ultimate responsibility for fulfilling the intentions of Nobel's will.</p> </div> <div class="footer-section"> <h5> <a href="/the-nobel-prize-organisation/prize-awarding-institutions/">The prize-awarding institutions</a> </h5> <p>For more than a century, these academic institutions have worked independently to select Nobel Prize laureates.</p> </div> <div class="footer-section"> <h5> <a href="/the-nobel-prize-organisation/outreach-organisations/">Outreach organisations</a> </h5> <p>Several outreach organisations and activities have been developed to inspire generations and disseminate knowledge about the Nobel Prize.</p> </div> </div> </section> <section class="footer-nav"> <nav class="footer-menu" role="navigation" itemscope="itemscope" itemtype="http://schema.org/SiteNavigationElement"> <ul id="menu-footer_col_1" class="footer-column-items" role="menu"><li id="menu-item-28266" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-28266" role="menuitem"><a href="https://www.nobelprize.org/press-room/">Press</a></li> <li id="menu-item-42845" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-42845" role="menuitem"><a href="https://www.nobelprize.org/contact">Contact</a></li> <li id="menu-item-28265" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-28265" role="menuitem"><a href="https://www.nobelprize.org/frequently-asked-questions/">FAQ</a></li> </ul> </nav> <nav class="footer-menu" role="navigation" itemscope="itemscope" itemtype="http://schema.org/SiteNavigationElement"> <ul id="menu-footer_col_2" class="footer-column-items" role="menu"><li id="menu-item-28268" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-28268" role="menuitem"><a href="/about/privacy-policy/">Privacy policy</a></li> <li id="menu-item-28269" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-28269" role="menuitem"><a href="/about/technical-support/">Technical support</a></li> <li id="menu-item-42844" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-42844" role="menuitem"><a href="/about/terms-of-use/">Terms of use</a></li> </ul> </nav> <nav class="footer-menu" role="navigation" itemscope="itemscope" itemtype="http://schema.org/SiteNavigationElement"> <ul id="menu-footer_col_3" class="footer-column-items" role="menu"><li id="menu-item-28272" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-28272" role="menuitem"><a href="/about/developer-zone/">For developers</a></li> <li id="menu-item-42843" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-42843" role="menuitem"><a href="/mediaplayer/">Media player</a></li> <li id="menu-item-224329" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-224329" role="menuitem"><a href="https://careers.nobelprize.org">Careers</a></li> </ul> </nav> <nav class="footer-menu footer-social" role="navigation" itemscope="itemscope" itemtype="http://schema.org/SiteNavigationElement"> <h6> Join us </h6> <ul id="menu-footer_social" class="socialmenu"><li id="menu-item-28273" class="facebook menu-item menu-item-type-custom menu-item-object-custom menu-item-28273" role="menuitem"><a href="https://www.facebook.com/nobelprize/"> <svg xmlns="http://www.w3.org/2000/svg" width="40" height="40" viewBox="0 0 40 40"><path d="M14.526 34h-3.96A4.572 4.572 0 0 1 6 29.43V10.57C6 8.051 8.051 6 10.571 6H29.43A4.577 4.577 0 0 1 34 10.57v18.854c0 2.52-2.051 4.57-4.571 4.57h-3.492a.573.573 0 0 1-.571-.571V22.305c0-.314.257-.571.571-.571h2.229l.405-3.228h-2.634a.573.573 0 0 1-.571-.571v-3.28c0-.314.257-.57.571-.57h2.709v-3.229h-4.892a1.62 1.62 0 0 0-1.617 1.617v5.462a.573.573 0 0 1-.571.571h-2.709v3.228h2.709c.314 0 .571.257.571.571v11.118a.59.59 0 0 1-.166.406c-.148.148-.171.171-7.44.171h-.005ZM10.57 7.143a3.43 3.43 0 0 0-3.428 3.427v18.854a3.43 3.43 0 0 0 3.423 3.428h10.423V22.87H18.28a.573.573 0 0 1-.571-.572v-4.37c0-.314.257-.571.571-.571h2.709v-4.89c0-1.52 1.24-2.76 2.76-2.76h5.462c.315 0 .572.257.572.571v4.37a.573.573 0 0 1-.572.572h-2.708v2.137h2.708a.56.56 0 0 1 .429.194c.109.126.16.286.137.451l-.548 4.37a.573.573 0 0 1-.566.504h-2.16v9.975h2.92a3.43 3.43 0 0 0 3.428-3.428V10.57a3.43 3.43 0 0 0-3.428-3.427H10.57Z"></path></svg> <span class="screen-reader-text">Facebook</span> </a></li> <li id="menu-item-28274" class="twitter menu-item menu-item-type-custom menu-item-object-custom menu-item-28274" role="menuitem"><a href="https://twitter.com/NobelPrize"> <svg xmlns="http://www.w3.org/2000/svg" width="40" height="40" viewBox="0 0 40 40"><path fill-rule="evenodd" d="M11.143 6h17.714A5.148 5.148 0 0 1 34 11.143v17.714A5.148 5.148 0 0 1 28.857 34H11.143A5.148 5.148 0 0 1 6 28.857V11.143A5.148 5.148 0 0 1 11.143 6Zm17.714 26.857c2.205 0 4-1.795 4-4V11.143c0-2.205-1.795-4-4-4H11.143c-2.205 0-4 1.795-4 4v17.714c0 2.205 1.795 4 4 4h17.714Zm-.995-22.384a.572.572 0 0 1 .847.768l-6.933 7.65 6.977 9.923a.572.572 0 0 1-.468.9h-3.714a.571.571 0 0 1-.468-.243l-5.205-7.404-6.76 7.46a.57.57 0 0 1-.808.04.572.572 0 0 1-.04-.808l6.934-7.65-6.977-9.923a.572.572 0 0 1 .468-.9h3.714c.186 0 .36.09.467.243l5.206 7.404 6.76-7.46Zm-15.047.956L24.869 28.57h2.317L15.132 11.43h-2.317Z" clip-rule="evenodd"></path></svg> <span class="screen-reader-text">Twitter</span> </a></li> <li id="menu-item-43144" class="instagram menu-item menu-item-type-custom menu-item-object-custom menu-item-43144" role="menuitem"><a href="https://www.instagram.com/nobelprize_org/?hl=en"> <svg xmlns="http://www.w3.org/2000/svg" width="40" height="40" viewBox="0 0 40 40"><path fill-rule="evenodd" d="M28.857 34H11.143A5.15 5.15 0 0 1 6 28.857V11.143A5.15 5.15 0 0 1 11.143 6h17.714A5.15 5.15 0 0 1 34 11.143v17.714A5.15 5.15 0 0 1 28.857 34ZM11.143 7.143c-2.206 0-4 1.794-4 4v17.714c0 2.206 1.794 4 4 4h17.714c2.206 0 4-1.794 4-4V11.143c0-2.206-1.794-4-4-4H11.143Zm8.857 20c-3.937 0-7.143-3.206-7.143-7.143s3.206-7.143 7.143-7.143 7.143 3.206 7.143 7.143-3.206 7.143-7.143 7.143ZM20 14c-3.309 0-6 2.691-6 6s2.691 6 6 6 6-2.691 6-6-2.691-6-6-6Zm6-2.286a2.285 2.285 0 1 0 4.57.001 2.285 2.285 0 0 0-4.57 0Zm1.143 0c0-.628.514-1.143 1.143-1.143.628 0 1.143.515 1.143 1.143 0 .629-.515 1.143-1.143 1.143a1.146 1.146 0 0 1-1.143-1.143Z" clip-rule="evenodd"></path></svg> <span class="screen-reader-text">Instagram</span> </a></li> <li id="menu-item-43145" class="youtube menu-item menu-item-type-custom menu-item-object-custom menu-item-43145" role="menuitem"><a href="https://www.youtube.com/thenobelprize"> <svg xmlns="http://www.w3.org/2000/svg" width="40" height="40" viewBox="0 0 40 40"><path fill-rule="evenodd" d="M11.143 34h17.714A5.15 5.15 0 0 0 34 28.857V11.143A5.15 5.15 0 0 0 28.857 6H11.143A5.15 5.15 0 0 0 6 11.143v17.714A5.15 5.15 0 0 0 11.143 34Zm-4-22.857c0-2.206 1.794-4 4-4h17.714c2.206 0 4 1.794 4 4v17.714c0 2.206-1.794 4-4 4H11.143c-2.206 0-4-1.794-4-4V11.143Zm20.2 15.143H12.65a2.753 2.753 0 0 1-2.748-2.749v-7.074a2.753 2.753 0 0 1 2.748-2.749h14.692a2.753 2.753 0 0 1 2.748 2.749v7.074a2.753 2.753 0 0 1-2.748 2.749ZM12.65 14.857c-.885 0-1.605.72-1.605 1.606v7.074c0 .886.72 1.606 1.605 1.606h14.692c.886 0 1.606-.72 1.606-1.606v-7.074c0-.886-.72-1.606-1.606-1.606H12.65Zm5.643 8.766a.753.753 0 0 1-.746-.749l-.022-5.748c0-.275.148-.526.383-.657a.753.753 0 0 1 .76.017l4.537 2.8a.746.746 0 0 1 .354.628.77.77 0 0 1-.337.64l-4.52 2.949a.766.766 0 0 1-.409.12Zm0 0h.003-.006.003Zm.375-5.794.017 4.32 3.394-2.218-3.411-2.108v.006Z" clip-rule="evenodd"></path></svg> <span class="screen-reader-text">Youtube</span> </a></li> <li id="menu-item-164548" class="linkedin menu-item menu-item-type-custom menu-item-object-custom menu-item-164548" role="menuitem"><a href="https://www.linkedin.com/company/nobelprize/"> <svg xmlns="http://www.w3.org/2000/svg" width="40" height="40" viewBox="0 0 40 40"><path fill-rule="evenodd" d="M12.909 14.251a2.557 2.557 0 0 1-2.555-2.554 2.56 2.56 0 0 1 2.555-2.554 2.56 2.56 0 0 1 2.554 2.554 2.56 2.56 0 0 1-2.554 2.554Zm0-3.965c-.778 0-1.412.634-1.412 1.411s.634 1.412 1.412 1.412c.777 0 1.411-.635 1.411-1.412 0-.777-.634-1.411-1.411-1.411Z" clip-rule="evenodd"></path><path d="M28.771 28.211c0 .315.258.572.572.572l-.006-.006a.573.573 0 0 0 .572-.571v-7.292c0-3.605-2.509-4.891-4.852-4.891-1.457 0-2.497.383-3.44 1v-.532a.573.573 0 0 0-.571-.571h-3.612a.573.573 0 0 0-.571.571v11.715c0 .314.257.571.571.571a.573.573 0 0 0 .572-.571V17.063h2.468v1.108a.574.574 0 0 0 .943.44c1.057-.891 2.034-1.44 3.646-1.44 1.114 0 3.708.366 3.708 3.749v7.291ZM14.611 28.783a.573.573 0 0 1-.571-.572V17.07h-2.543V28.21a.573.573 0 0 1-.571.572.573.573 0 0 1-.572-.572V16.497c0-.314.257-.571.572-.571h3.685c.315 0 .572.257.572.571v11.714a.573.573 0 0 1-.572.572Z"></path><path d="M25.657 28.783a.573.573 0 0 1-.571-.572V22.83c0-1.286-.412-1.738-1.577-1.738-1.252 0-1.886.458-1.886 1.355v5.765a.573.573 0 0 1-.572.572.573.573 0 0 1-.571-.572v-5.765c0-1.56 1.131-2.497 3.029-2.497 1.897 0 2.72.971 2.72 2.88v5.382a.573.573 0 0 1-.572.572Z"></path><path fill-rule="evenodd" d="M11.143 34h17.714A5.15 5.15 0 0 0 34 28.857V11.143A5.15 5.15 0 0 0 28.857 6H11.143A5.15 5.15 0 0 0 6 11.143v17.714A5.15 5.15 0 0 0 11.143 34Zm-4-22.857c0-2.206 1.794-4 4-4h17.714c2.206 0 4 1.794 4 4v17.714c0 2.206-1.794 4-4 4H11.143c-2.206 0-4-1.794-4-4V11.143Z" clip-rule="evenodd"></path></svg> <span class="screen-reader-text">LinkedIn</span> </a></li> </ul> </nav> </section> <section class="colophon border-top"> <div class="footer-logo" itemscope itemtype="http://schema.org/Organization"> <p class="site-logo" itemprop="logo"> <a itemprop="url" href="https://www.nobelprize.org"> The Nobel Prize </a> </p> </div> <div class="copyright"> Copyright © Nobel Prize Outreach AB 2024 </div> </section> </div> </footer> <button type="button" class="to-top" tabindex="-1"> <span class="screen-reader-text"> Scroll to top </span> <svg xmlns="http://www.w3.org/2000/svg" width="45.999" height="26.001" viewBox="0 0 45.999 26.001"><path xmlns="http://www.w3.org/2000/svg" fill="#FFF" d="M5.905 24.997a3.484 3.484 0 0 1-4.893 0 3.403 3.403 0 0 1 0-4.845l19.54-19.149a3.486 3.486 0 0 1 4.895 0l19.538 19.15a3.4 3.4 0 0 1 0 4.845 3.485 3.485 0 0 1-4.893.001L22.999 9.294z"/></svg></button> <script data-cfasync="false" src="/cdn-cgi/scripts/5c5dd728/cloudflare-static/email-decode.min.js"></script><script> window.lazySizesConfig = window.lazySizesConfig || {}; window.lazySizesConfig.pictureRenderer = '1.1'; window.lazySizesConfig.customMedia = {"--small":"(min-width: 220px)","--medium":"(min-width: 900px)","--large":"(min-width: 1400px)","mobile":"(min-width: 220px)","tablet":"(min-width: 900px)","desktop":"(min-width: 1400px)"}; </script><script type="text/javascript" src="https://www.nobelprize.org/wp-content/plugins/nobelprize-block-library/dist/js/frontend.js?ver=9af3caa4ba4635a79486" id="nobelprize_block_library_frontend-js"></script> <script type="text/javascript" src="https://www.nobelprize.org/wp-content/themes/nobelprize/dist/js/frontend.js?ver=0fc4ea04d626abf846ed" id="frontend-js"></script> <script type="text/javascript" src="https://www.nobelprize.org/wp-content/themes/nobelprize/assets/js/frontend/lib/bgset/ls.bgset.min.js?ver=1732293022" id="lazy-sizes-bg-set-js"></script> <script type="text/javascript" src="https://www.nobelprize.org/wp-content/themes/nobelprize/assets/js/frontend/lib/lazysizes/lazysizes.min.js?ver=1732293022" id="lazy-sizes-js"></script> <script type="text/javascript" src="https://www.nobelprize.org/wp-content/themes/nobelprize/assets/js/frontend/lib/objectfit/ls.object-fit.min.js?ver=1732293022" id="lazy-sizes-object-fit-js"></script> <script type="text/javascript" src="https://www.nobelprize.org/wp-content/plugins/nobelprize/assets/js/admin/lib/flickity/flickity.pkgd.js?ver=1732293022" id="flickity-js"></script> <script type="text/javascript" src="https://www.nobelprize.org/wp-content/themes/nobelprize/assets/js/frontend/lib/clamp/clamp.min.js?ver=1732293022" id="clamp-js"></script> <script type="text/javascript" src="https://stats.wp.com/e-202448.js" id="jetpack-stats-js" data-wp-strategy="defer"></script> <script type="text/javascript" id="jetpack-stats-js-after"> /* <![CDATA[ */ _stq = window._stq || []; _stq.push([ "view", JSON.parse("{\"v\":\"ext\",\"blog\":\"197939892\",\"post\":\"0\",\"tz\":\"1\",\"srv\":\"www.nobelprize.org\",\"j\":\"1:13.9.1\"}") ]); _stq.push([ "clickTrackerInit", "197939892", "0" ]); /* ]]> */ </script> <script type="text/javascript">window.NREUM||(NREUM={});NREUM.info={"beacon":"bam.eu01.nr-data.net","licenseKey":"NRJS-0940f7eaf4cb46e1cfe","applicationID":"212354543","transactionName":"MhBSZQoZXUZZB0UMCwtac0QLDFxYFyZdCgNFJVFWHQ==","queueTime":0,"applicationTime":1000,"atts":"HldFE0IDThkaBRNfHxgI","errorBeacon":"bam.eu01.nr-data.net","agent":""}</script></body> </html>