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<!DOCTYPE html> <html lang="de"> <head> <meta charset="utf-8">  <title>FACS-basierte Screening Plattform f眉r die Entwicklung neuer immunmodulatorische Molek眉le - Transfusionsmedizin | Uniklinikum Erlangen</title> <meta http-equiv="x-ua-compatible" content="IE=edge"> <meta name="generator" content="TYPO3 CMS"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1"> <meta name="robots" content="index,follow"> <meta name="twitter:card" content="summary"> <meta name="apple-mobile-web-app-capable" content="no"> <meta name="google" content="notranslate"> <link rel="stylesheet" href="/_assets/d62557c271d06262fbb7ce0981266e2f/Css/auto-complete.1732120249.css" media="all"> <link rel="stylesheet" href="/_assets/db5fd2ca3057ef07b5244af171451057/Css/ods_osm.1714687028.css" media="all"> <link rel="stylesheet" href="/_frontend/website/bundled/css/default.6c6d42ec.1730828947.css" media="all"> <style> #frame-backgroundimage-1022470 { background-image: 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suchen... </label><span class="icon icon-search"></span><input id="globalSearchInput" class="search-input" data-testid="search-input" type="text" name="tx_kesearch_pi1[sword]" placeholder="Nach Thema, Fachgebiet, Name des Arztes suchen..." /><button type="submit" class="btn btn-primary" data-testid="search-submit-button" > Suchen </button></form></div></div></nav><nav id="accessibility-navigation" class="navbar-accessibility" aria-label="Barrierefreiheits-Optionen" ><ul class="navbar__list navbar__list--accessibility"><li class="navbar__item navbar__item--leichte-sprache"></li><li class="navbar__item navbar__item--contrast"><et-state-toggle el="body" active-class="t-contrast" cookie="contrastMode" inactive-class="t-default" ><button class="navbar__link" aria-label="Ansicht f眉r hohen Kontrast" title="Ansicht f眉r hohen Kontrast" ><span class="icon icon--contrast"></span></button></et-state-toggle></li><li class="navbar__item navbar__item--font-size"><et-popover-root><et-popover-trigger><button class="navbar__link" aria-label="Hinweise f眉r die Anpassung der Schriftgr枚脽e zeigen" title="Hinweise f眉r die Anpassung der Schriftgr枚脽e zeigen" ><span class="icon icon--fontsize"></span></button></et-popover-trigger><et-popover-content><dialog class="popover-dialog" aria-label="Hinweise f眉r die Anpassung der Schriftgr枚脽e" ><form method="dialog"><button class="button close" aria-label="Schlie脽en" ><svg xmlns="http://www.w3.org/2000/svg" width="28" height="28" fill="currentColor" class="bi bi-x-lg" viewBox="0 0 16 16"><path d="M2.146 2.854a.5.5 0 1 1 .708-.708L8 7.293l5.146-5.147a.5.5 0 0 1 .708.708L8.707 8l5.147 5.146a.5.5 0 0 1-.708.708L8 8.707l-5.146 5.147a.5.5 0 0 1-.708-.708L7.293 8z"/></svg></button></form><div class="popover-dialog__content"><h3>Schriftgr枚脽e anpassen</h3><p><b>F眉r Windows / Linux:</b><br> Mit diesen Tastenkombinationen k枚nnen Sie die Schriftgr枚脽e anpassen:<br></p><ul class="list-normal"><li>[Strg] - [+]: Schrift vergr枚脽ern</li><li>[Strg] - [-]: Schrift verkleinern</li><li>[Strg] - [0]: Schriftgr枚脽e zur眉cksetzen</li></ul><br><p><b>F眉r Mac:</b><br> Mit diesen Tastenkombinationen k枚nnen Sie die Schriftgr枚脽e anpassen:<br></p><ul class="list-normal"><li>[Cmd] - [+]: Schrift vergr枚脽ern</li><li>[Cmd] - [-]: Schrift verkleinern</li><li>[Cmd] - [0]: Schriftgr枚脽e zur眉cksetzen</li></ul></div><et-popover-arrow></et-popover-arrow></dialog></et-popover-content></et-popover-root></li></ul></nav></div></div></div></div><div class="menu-main-container bg-blue-darkest"><div class="main-navigation-button-container frame-container frame-container-default d-md-none"><button class="btn main-navigation-button p-4" type="button" data-bs-toggle="offcanvas" data-bs-target="#main-navigation" aria-controls="main-navigation" aria-label="Men眉枚ffnen" ><span class="burger-icon"></span></button></div><nav id="main-navigation" tabindex="-1" class="navbar navbar-main frame-container 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collapse show"><li class="navbar__item has-children active"><a href="/forschung/forschungslabor-trc/" class="navbar__link active" title="Forschungslabor TRC"><span class="icon icon-arrow_right d-md-none"></span><span>Forschungslabor TRC</span></a><ul id="navlist1022430" class="navbar__list collapse show"><li class="navbar__item"><a href="/forschung/forschungslabor-trc/automatisierung-eines-immunologischen-forschungslabors/" class="navbar__link " title="Automatisierung eines immunologischen Forschungslabors"><span>Automatisierung eines immunologischen Forschungslabors</span></a></li><li class="navbar__item"><a href="/forschung/forschungslabor-trc/extrakorporale-photopherese/" class="navbar__link " title="Extrakorporale Photopherese"><span>Extrakorporale Photopherese</span></a></li><li class="navbar__item active"><a href="/forschung/forschungslabor-trc/facs-basierte-screening-plattform-fuer-die-entwicklung-neuer-immunmodulatorische-molekuele/" class="navbar__link active" title="FACS-basierte Screening Plattform f眉r die Entwicklung neuer immunmodulatorische Molek眉le"><span class="icon icon-arrow_right d-md-none"></span><span>FACS-basierte Screening Plattform f眉r die Entwicklung neuer immunmodulatorische Molek眉le <span class="sr-only">(current)</span></span></a></li><li class="navbar__item"><a href="/forschung/forschungslabor-trc/flexible-automatisierung-der-covid-19-analytik-flexaco/" class="navbar__link " title="Flexible Automatisierung der COVID-19 Analytik (FlexACO)"><span>Flexible Automatisierung der COVID-19 Analytik (FlexACO)</span></a></li><li class="navbar__item"><a href="/forschung-und-lehre/forschungslabor-trc/untersuchung-haemostaseologisch-relevanter-genvarianten-mittels-next-generation-sequencing/" class="navbar__link " title="Untersuchung h盲mostaseologisch relevanter Genvarianten mittels Next Generation Sequencing"><span>Untersuchung h盲mostaseologisch relevanter Genvarianten mittels Next Generation Sequencing</span></a></li><li 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Dies kann durch k枚rpereigene Stoffe oder durch pharmakologisch wirksame Substanzen bewirkt werden, welche immunstimulierende oder -hemmende Eigenschaften haben.</p><p>Das m枚gliche Indikationsspektrum reicht von Allergien, Infektionen und Tumoren bis hin zu Autoimmunerkrankungen. Ziel dieses Projekts ist es zum einen ein besseres Verst盲ndnis der immunmodulierenden Wirkung von bereits bekannten Substanzen zu erhalten und zum anderen neue Immunmodulatoren mit einem verbesserten Wirkprofil zu identifizieren. Daf眉r kommen verschiedener immunologischer Methoden zum Einsatz, welche in humanen Vollblutproben oder humanen peripheren mononukle盲ren Blutzellen (PBMCs) die immunmodulierende Wirkung anhand der Aussch眉ttung von Zytokinen und spezifischer Oberfl盲chenmarker erm枚glichen. Naturstoffe bilden eine unersch枚pfliche Quelle an potentiellen Arzneimitteln, die f眉r die klinische Forschung von gro脽em Interesse sind.</p><p>Um potentielle neue Immunmodulatoren aus gro脽en Substanzbibliotheken mittels Hochdurchsatz-Screening zu entdecken, soll ein zellbasiertes Testsystem unter Verwendung von Fluoreszenz-Durchflusszytometrie etabliert werden.</p></div></div></div></div></div></div></div><div id="c74599" class=" frame frame-default frame-type-list frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="frame-header"><h3 class="element-header "><span>Ansprechpartner</span></h3></div><div class="result-list-items contact-items result-list-items-glossar columnsCount2"><div class="result-list-item"><div class="list-item-text"><div class="category-flag-wrapper"><div class="category-flag"><a title="脰ffnet die Webseite von Transfusionsmedizin" target="_blank" href="/">Transfusionsmedizin</a></div></div><h4><a title="脰ffnet die Visitenkarte von Dr. rer. nat. 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