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0px;width:100%"><h2><span style="font-family:"Roboto Slab"" class="__bold">PacBio announces update to sequencing system to bring down cost of genome sample to below $500</span></h2></div></div><div id="outer" data-widget="paragraph-widget" style="background-color:transparent;padding:0px 24px 8px 24px;text-align:left;font-size:100%;line-height:1.3;letter-spacing:0" class="Widget-module_outer__PBh8P Paragraph-module_container__-DJUN"><div id="inner" style="border-radius:0px 0px 0px 0px;width:100%;column-count:1"><p><span class="__bold" style="color:rgb(38,37,35)">Announced by PacBio, known for developing sequencing solutions, SPRQ has the potential to significantly reduce the cost of sequencing genomes. </span></p></div></div><div id="outer" data-widget="paragraph-widget" style="background-color:transparent;padding:0px 24px 8px 24px;text-align:left;font-size:100%;line-height:1.3;letter-spacing:0" class="Widget-module_outer__PBh8P Paragraph-module_container__-DJUN"><div id="inner" style="border-radius:0px 0px 0px 0px;width:100%;column-count:1"><p>The company claims that these changes – which are also compatible with previously released Revio systems – would enable each instrument to sequence an average of 2,500 human whole genomes annually, with an average of $500 per human genome.</p></div></div><div id="outer" data-widget="paragraph-widget" style="background-color:transparent;padding:0px 24px 8px 24px;text-align:left;font-size:100%;line-height:1.3;letter-spacing:0" class="Widget-module_outer__PBh8P Paragraph-module_container__-DJUN"><div id="inner" style="border-radius:0px 0px 0px 0px;width:100%;column-count:1"><p>Christian Henry, president and CEO of PacBio stated, “We’ve seen tremendous demand for Revio systems over the last two years as many more researchers have discovered the superiority of HiFi technology in population sequencing and other human and non-human sequencing applications… Our team has achieved significant breakthroughs, which significantly improves the performance and reduces the cost of a HiFi human genome to less than <span>$500 per sample. The SPRQ chemistry opens the possibility for more samples to be sequenced using Revio systems. This chemistry is compatible with all Revios in the field with just a very simple software update. Its launch is a true inflection point for PacBio – setting a new trajectory of customer adoption and scientific discovery.”</span></p></div></div><div id="outer" data-widget="image-widget" style="background-color:transparent;padding:8px 24px 16px 24px;min-height:auto" class="Widget-module_outer__PBh8P"><div id="inner" class="Image-module_container__8raIv Image-module_container-noflex__-J1PG" style="border-radius:0px 0px 0px 0px;width:100%;min-height:auto"><picture class="Image-module_picture__gw1zY Image-module_loading__FfyPr"><source type="image/jpeg" srcSet="https://cdn.magloft.com/pdf-import/1144/images/img_6-2.jpg?optimizer=image&width=192 192w,https://cdn.magloft.com/pdf-import/1144/images/img_6-2.jpg?optimizer=image&width=384 384w,https://cdn.magloft.com/pdf-import/1144/images/img_6-2.jpg?optimizer=image&width=768 768w,https://cdn.magloft.com/pdf-import/1144/images/img_6-2.jpg?optimizer=image&width=1536 1536w" sizes="(min-width: 768px) 768px, 100vw"/><img src="https://cdn.magloft.com/pdf-import/1144/images/img_6-2.jpg?optimizer=image&width=768" srcSet="https://cdn.magloft.com/pdf-import/1144/images/img_6-2.jpg?optimizer=image&width=192 192w,https://cdn.magloft.com/pdf-import/1144/images/img_6-2.jpg?optimizer=image&width=384 384w,https://cdn.magloft.com/pdf-import/1144/images/img_6-2.jpg?optimizer=image&width=768 768w,https://cdn.magloft.com/pdf-import/1144/images/img_6-2.jpg?optimizer=image&width=1536 1536w" sizes="(min-width: 768px) 768px, 100vw" class="Image-module_image__w4slc" width="100%" height="575" decoding="async" alt="Image" style="height:auto;width:100%"/></picture></div></div><div id="outer" data-widget="paragraph-widget" style="background-color:transparent;padding:0px 24px 8px 24px;text-align:left;font-size:100%;line-height:1.3;letter-spacing:0" class="Widget-module_outer__PBh8P Paragraph-module_container__-DJUN"><div id="inner" style="border-radius:0px 0px 0px 0px;width:100%;column-count:1"><p>Using improved sequencing chemistry for the company’s previously released Revio long-read sequencing system, SPRQ reduces DNA input requirements by an average of four times, to as little as 500ng per sample. This enables more sample types to be analysed, including saliva samples, and also allows for pairing with other sequencing technologies such as HiFi sequencing for analysis of tumours. The different SPRQ chemistry also aims to improve sequencing performance, up to a 33% increase in yield per cell.</p></div></div><div id="outer" data-widget="paragraph-widget" style="background-color:transparent;padding:0px 24px 8px 24px;text-align:left;font-size:100%;line-height:1.3;letter-spacing:0" class="Widget-module_outer__PBh8P Paragraph-module_container__-DJUN"><div id="inner" style="border-radius:0px 0px 0px 0px;width:100%;column-count:1"><p>“Increased yields and reduced input requirements are a big win for our user community,” added Niall Lennon, chair and CSO of Broad Clinical Labs. “In studies where we had many samples that we could not have generated long reads on before, we were able to rescue 80% of these samples using the SPRQ chemistry. Higher success rates and lower costs for long-read data generation increases access to a wider range of scientific applications and accelerates the pace of discovery.”</p></div></div></div></div></div><div class="_slug__share-button__ettip"><hr/></div></div></div><div id="ControlBar" class="_slug__control-bar__Jj4LE"><div class="WrapAutoHide-module_navigation__9sdQy WrapAutoHide-module_visible__UN7GD"><div class="ControlBar-module_toc-wrapper__AF5eD"><div class="ControlBar-module_toc__mKXnp"><div class="ControlBar-module_white-blur__TGapK"><div class="ControlBar-module_toc-slider__i9fv1"></div></div><div class="ControlBar-module_control-bar__9Zqak"><button class=""><svg xmlns="http://www.w3.org/2000/svg" width="24" height="24" viewBox="0 0 24 24" fill="none"><path d="M13.8287 19C13.5367 19 13.2467 18.873 13.0487 18.627L8.22066 12.627C7.92266 12.256 7.92666 11.726 8.23166 11.36L13.2317 5.35998C13.5847 4.93598 14.2157 4.87898 14.6407 5.23198C15.0647 5.58498 15.1217 6.21598 14.7677 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by PacBio, known for developing sequencing solutions, SPRQ has the potential to significantly reduce the cost of sequencing genomes.","image":"https://cdn.magloft.com/pdf-import/1144/images/img_6-2.jpg","cover":"https://cdn.magloft.com/publication-14882/screenshots/articles/269377.jpg?ts=1731582787","date":1731628800000,"unlockType":"free","categories":[],"pdfPageId":"RgaqyVRZTJnr","visible":true,"showOnToc":true,"bookmark":false,"position":13,"publicationId":14882,"pwaOptinId":null,"seoDescription":"Announced by Pacbio, known for developing sequencing solutions, SPRQ has the potential to significantly reduce the cost of sequencing genomes.","classificationIds":[],"pwaSubscriptionIds":[],"source":"typeloft2","trending":false,"html":"\u003cpage-widget padding=\"16 0 24 0\"\u003e\u003cparagraph-widget padding=\"0 24 0 24\"\u003eNews\u003c/paragraph-widget\u003e\u003chorizontal-rule-widget padding=\"0 24 0 24\" color=\"#a31f29\"\u003e\u003c/horizontal-rule-widget\u003e\u003cheading-widget padding=\"0 24 16 24\" type=\"h2\"\u003e\u003cspan style=\"font-family: \u0026quot;Roboto Slab\u0026quot;;\" class=\"__bold\"\u003ePacBio announces update to sequencing system to bring down cost of genome sample to below $500\u003c/span\u003e\u003c/heading-widget\u003e\u003cparagraph-widget padding=\"0 24 8 24\"\u003e\u003cspan class=\"__bold\" style=\"color: rgb(38,37,35)\"\u003eAnnounced by PacBio, known for developing sequencing solutions, SPRQ has the potential to significantly reduce the cost of sequencing genomes. \u003c/span\u003e\u003c/paragraph-widget\u003e\u003cparagraph-widget padding=\"0 24 8 24\"\u003eThe company claims that these changes – which are also compatible with previously released Revio systems – would enable each instrument to sequence an average of 2,500 human whole genomes annually, with an average of $500 per human genome.\u003c/paragraph-widget\u003e\u003cparagraph-widget padding=\"0 24 8 24\"\u003eChristian Henry, president and CEO of PacBio stated, “We’ve seen tremendous demand for Revio systems over the last two years as many more researchers have discovered the superiority of HiFi technology in population sequencing and other human and non-human sequencing applications… Our team has achieved significant breakthroughs, which significantly improves the performance and reduces the cost of a HiFi human genome to less than \u003cspan\u003e$500 per sample. The SPRQ chemistry opens the possibility for more samples to be sequenced using Revio systems. This chemistry is compatible with all Revios in the field with just a very simple software update. Its launch is a true inflection point for PacBio – setting a new trajectory of customer adoption and scientific discovery.”\u003c/span\u003e\u003c/paragraph-widget\u003e\u003cimage-widget padding=\"8 24 16 24\" aspect-ratio=\"0.7486252945797329\" magnify-label=\"center\" source=\"https://cdn.magloft.com/pdf-import/1144/images/img_6-2.jpg#image/jpeg\"\u003e\u003c/image-widget\u003e\u003cparagraph-widget padding=\"0 24 8 24\"\u003eUsing improved sequencing chemistry for the company’s previously released Revio long-read sequencing system, SPRQ reduces DNA input requirements by an average of four times, to as little as 500ng per sample. This enables more sample types to be analysed, including saliva samples, and also allows for pairing with other sequencing technologies such as HiFi sequencing for analysis of tumours. The different SPRQ chemistry also aims to improve sequencing performance, up to a 33% increase in yield per cell.\u003c/paragraph-widget\u003e\u003cparagraph-widget padding=\"0 24 8 24\"\u003e“Increased yields and reduced input requirements are a big win for our user community,” added Niall Lennon, chair and CSO of Broad Clinical Labs. “In studies where we had many samples that we could not have generated long reads on before, we were able to rescue 80% of these samples using the SPRQ chemistry. Higher success rates and lower costs for long-read data generation increases access to a wider range of scientific applications and accelerates the pace of discovery.”\u003c/paragraph-widget\u003e\u003c/page-widget\u003e","keywordPhrase":"PacBio","articleAssets":[{"url":"https://cdn.magloft.com/reader/fonts/roboto-slab.css","extension":"css","contentType":"text/css"},{"url":"https://cdn.magloft.com/reader/fonts/open-sans.css","extension":"css","contentType":"text/css"},{"url":"https://cdn.magloft.com/pdf-import/1144/images/img_6-2.jpg","extension":"jpeg","contentType":"image/jpeg"}]},"publicationId":14882},"__N_SSG":true},"page":"/domains/[domain]/articles/[slug]","query":{"domain":"www.pharmafocus.com","slug":"pac-bio-announces-update-to-sequencing-system-to-bring-down-cost-7ecd"},"buildId":"U1LT7ce93wR6IyWFJCllT","isFallback":false,"gsp":true,"scriptLoader":[]}</script></body></html>