CINXE.COM

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class="btn">Join Us</a></li></ul></li> <li class="last leaf"><a href="/support/contact-us" id="menu-master-menu-116471">Contact Us</a></li> </ul> </div> </div> </div> </nav> </div> </header> <div class="container_16"> <div id="page-breadcrumb" class="grid_16"> <h2 class="element-invisible">You are here</h2><div class="breadcrumb"><a href="/">Home</a> » <a href="/resources">Resources</a> » <a href="/blog">Blog</a> » Stem Cells in the News - February 2019</div> </div> <div class="main grid_11" itemscope itemtype="http://schema.org/Blog"> <h1 itemprop="name">Stem Cells in the News - February 2019</h1> <div itemprop="dateCreated" content="20190204">Monday, February 04, 2019 - 10:44</div> <div itemprop="text"> <div class="region region-content"> <div id="block-et-messages-et-messages-block" class="block block-et-messages"> <div class="content"> <span></span> </div> </div> <div id="block-system-main" class="block block-system"> <div class="content"> <div id="node-1097796" class="node node-blog clearfix" about="/blog/stem-cells-news-february-2019" typeof="sioc:Item foaf:Document"> <span property="dc:title" content="Stem Cells in the News - February 2019" class="rdf-meta element-hidden"></span><span property="sioc:num_replies" content="0" datatype="xsd:integer" class="rdf-meta element-hidden"></span> <div class="content"> <div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even" property="content:encoded"><div style="height: 250px;overflow:hidden;">https://origin-rndsystemsstg.corpenttech.com/blog/stem-cells-news-february-2019<img alt="Stem Cells in the News" src="https://resources.rndsystems.com/images/blog/in-the-news-blog-header-realv2.png" style="position:relative; top: -35px;" width="635" /></div> <p><a id="drugtargetreview1" name="drugtargetreview1"></a></p> <p>We have captured this month’s most interesting, innovative, and maybe some of the strangest examples of stem cells in the news from around the world.</p> <section id="research-block"> <div id="card-feature"> <div class="external-link"> <h3><a href="https://www.drugtargetreview.com/news/36738/biomaterial-stem-cell-strokes/" target="_blank">Unique Biomaterials to Enhance Stem Cell Therapy for Stroke</a></h3> </div> <div class="container"> <h4><a href="https://www.drugtargetreview.com/news/36738/biomaterial-stem-cell-strokes/" target="_blank">Drug Target Review</a></h4> <p>Researchers from Spain have used a novel hydrogel-based encapsulation technology to develop stem cell therapies for stroke using a mouse model. They observed that encapsulated stem cells delivered to mice improved cell survival following stroke. In addition, improved tissue repair and preservation were observed. This hydrogel-based stem cell delivery method could be applied to treat damaged brain tissue in other conditions such as Alzheimer’s Disease, Parkinson’s Disease, and brain trauma.</p> </div> <a id="fatetherapeutics1" name="fatetherapeutics1"></a></div> <div id="card"> <div class="external-link"> <h3><a href="https://ir.fatetherapeutics.com/news-releases/news-release-details/fate-therapeutics-announces-fda-clearance-landmark-ind-ft500" target="_blank">Fate Therapeutics Announce FDA Clearance of iPSC-derived NK Cell Therapy</a></h3> </div> <div class="container"> <h4><a href="https://ir.fatetherapeutics.com/news-releases/news-release-details/fate-therapeutics-announces-fda-clearance-landmark-ind-ft500" target="_blank">Fate Therapeutics</a></h4> <p>Fate Therapeutics was authorized the first Investigational New Drug (IND) for an immune cell therapy derived from induced pluripotent stem cells (iPSC). Their product, FT500, is an allogeneic iPSC-derived natural killer (NK) cell therapy for the treatment of cancer. By using iPSCs as starting material, Fate Therapeutics can manufacture NK cells in a scalable and cost-effective manner to offer a cell therapy product that circumvents current challenges that personalized, patient-derived autologous therapies must overcome.</p> </div> <a id="gen1" name="gen1"></a></div> <div id="card"> <div class="external-link"> <h3><a href="https://www.genengnews.com/news/cancer-fighting-t-cells-produced-continuously-through-new-method/" target="_blank">Making Organoids into T Cell Factories</a></h3> </div> <div class="container"> <h4><a href="https://www.genengnews.com/news/cancer-fighting-t-cells-produced-continuously-through-new-method/" target="_blank">GEN</a></h4> <p>A recent study published in <em>Cell Stem Cell</em> showed that induced pluripotent stem cell (iPSC)-derived thymic organoids can provide a continual source of T cell production <em>in vitro</em>. This research, performed in the lab of Dr. Gay Crooks at the University of California – Los Angeles (UCLA), details a new approach for T cell production. This new technology has the potential to help advance immuno-oncology therapies for cancer by expediting the <em>in vitro</em> production of tumor-killing T cells.</p> </div> <a id="nature1" name="nature1"></a></div> <div id="card"> <div class="external-link"> <h3><a href="https://www.nature.com/articles/d41586-019-00246-2" target="_blank">University Issues Repercussions for CRISPR-Baby Scientist</a></h3> </div> <div class="container"> <h4><a href="https://www.nature.com/articles/d41586-019-00246-2" target="_blank">Nature News</a></h4> <p>Southern University of Science and Technology in Shenzhen, China, has announced the firing of He Jiankui, the scientist who produced the world’s first gene-edited babies. He announced in late 2018 that he had successfully gene-edited human embryos to make them HIV-resistant, using Crispr-Cas9 to disable the CCR5 gene. The investigative report issued indicated that He acted of his own volition and in violation of national regulations that limit the pursuit of HIV-infected individuals for assisted reproduction.</p> </div> <a id="stemcellreports1" name="stemcellreports1"></a></div> <div id="card"> <div class="external-link"> <h3><a href="https://www.sciencedirect.com/science/article/pii/S187350611830285X?via%3Dihub" target="_blank">Standardizing Pluripotency Assays for Patient-derived iPS Cell Lines</a></h3> </div> <div class="container"> <h4><a href="https://www.sciencedirect.com/science/article/pii/S187350611830285X?via%3Dihub" target="_blank">Stem Cell Reports</a></h4> <p>Stem Cell Core Facilities at Columbia University and Children’s Hospital of Philadelphia have published research detailing methods establishing stem cell lines from patients with genetic mutations resulting in <a href="https://www.sciencedirect.com/science/article/pii/S187350611830285X?via%3Dihub">Ocular albinism type 1</a> and <a href="https://www.sciencedirect.com/science/article/pii/S1873506118302915">Spinocerebellar Ataxia Type 2</a>, respectively. These two studies, published in Stem Cell Reports, validated the pluripotency of their newly-derived stem cell lines using the <a href="/products/human-pluripotent-stem-cell-functional-identification-kit_sc027b">Human Pluripotent Stem Cell Functional Identification Kit</a> from R&D Systems. These publications continue to progress the standardization for the derivation of patient-derived pluripotent stem cell lines for the study of human disease.</p> </div> <a id="technologynetworks1" name="technologynetworks1"></a></div> <div id="card"> <div class="external-link"> <h3><a href="https://www.technologynetworks.com/biopharma/news/platelets-grown-from-stem-cells-may-be-alternative-to-donated-platelet-312390" target="_blank">Platelet Alternative from MSCs may Bridge Donation Gap</a></h3> </div> <div class="container"> <h4><a href="https://www.technologynetworks.com/biopharma/news/platelets-grown-from-stem-cells-may-be-alternative-to-donated-platelet-312390" target="_blank">Technology Networks</a></h4> <p>Researchers from Keio University School of Medicine in Tokyo, Japan, serendipitously discovered that adipose stem cells could be used to derive platelets. Initial studies trying to coax induced pluripotent stem cells (iPSCs) to differentiate into platelets led to the discovery that the control cells, adipose stem cells, were actually better at producing the desired platelet population. The detailed protocol produces platelets from adipose stem cells in 12 days. Currently adipose stem cells are more difficult to isolate than working with iPSCs. This model, however, has the potential to provide an allogeneic platelet therapy that could address supply shortcomings for donated plasma-derived platelets.</p> </div> <a id="gen2" name="gen2"></a></div> <div id="card"> <div class="external-link"> <h3><a href="https://www.genengnews.com/news/team-discovers-that-the-human-intestine-may-provide-up-to-10-percent-of-blood-cells-in-circulation-from-its-own-reservoir-of-blood-forming-stem-cells/" target="_blank">Reservoir of HSCs Discovered in the Human Gut</a></h3> </div> <div class="container"> <h4><a href="https://www.genengnews.com/news/team-discovers-that-the-human-intestine-may-provide-up-to-10-percent-of-blood-cells-in-circulation-from-its-own-reservoir-of-blood-forming-stem-cells/" target="_blank">GEN News</a></h4> <p>A recent study in <em>Cell Stem Cell</em> reported that intestinal transplant tissue harbors a population of donor hematopoietic stem cells (HSCs). According to researchers at Columbia University’s Vagelos College of Physicians and Surgeons, these HSCs become educated by the recipient and help to promote engraftment tolerance. Intestine transplantation is often the last resort of therapy for Crohn’s disease patients, but can be confounded by host-rejection. These findings suggest a new avenue of research and therapy that circumvent the current engraftment challenges of intestinal tissue.</p> </div> <a id="wsj1" name="wsj1"></a></div> <div id="card"> <div class="external-link"> <h3><a href="https://madison.com/wsj/news/local/health-med-fit/stem-cell-therapy-developed-at-uw-madison-tested-in-clinical/article_e265fe48-3134-5615-b145-18b5263065d8.html" target="_blank">GVHD Stem Cell Therapy Reporting Phase 1 Trial Results</a></h3> </div> <div class="container"> <h4><a href="https://madison.com/wsj/news/local/health-med-fit/stem-cell-therapy-developed-at-uw-madison-tested-in-clinical/article_e265fe48-3134-5615-b145-18b5263065d8.html" target="_blank">Wisconsin State Journal</a></h4> <p>In a joint effort between the University of Wisconsin at Madison and Cynata Therapeutics, the first induced pluripotent stem cell (iPSC) therapy developed out of UW – Madison has released results of their Phase 1 clinical trial for graft versus host diseases (GVHD). The therapy utilizes iPSCs to provide a steady supply of mesenchymal stem cells to help modulate the patient immune system and prevent symptoms of GVHD after transplantation. The promising results of this Phase 1 trial have motivated the expanded therapeutic application of this technology.</p> </div> <a id="reuters1" name="reuters1"></a></div> <div id="card"> <div class="external-link"> <h3><a href="https://www.reuters.com/article/us-brainstorm-cell-study/brainstorm-gets-fda-okay-for-stem-cell-trial-in-ms-patients-idUSKBN1OG1EX" target="_blank">BrainStorm Therapeutics gets FDA Clearance to Test Stem Cell Therapy in MS Patients</a></h3> </div> <div class="container"> <h4><a href="https://www.reuters.com/article/us-brainstorm-cell-study/brainstorm-gets-fda-okay-for-stem-cell-trial-in-ms-patients-idUSKBN1OG1EX" target="_blank">Reuters</a></h4> <p>Currently there are cellular therapies for multiple sclerosis (MS) or other neurological diseases that are approved by the U.S. Food and Drug Administration (FDA). Israel-based BrainStorm Therapeutics announced that the FDA has approved their stem cell therapy for the treatment of progressive MS. 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