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href="http://dbpedia.org/resource/Enzyme_activator">Enzyme activator</a> </h1> </div> </div> <div class="row"> <div class="col"> <div class="text-muted"> An Entity of Type: <a href="http://dbpedia.org/ontology/Protein">protein</a>, from Named Graph: <a href="http://dbpedia.org">http://dbpedia.org</a>, within Data Space: <a href="http://dbpedia.org">dbpedia.org</a> </div> </div> </div> <div class="row pt-2"> <div class="col-xs-9 col-sm-10"> Enzyme activators are molecules that bind to enzymes and increase their activity. They are the opposite of enzyme inhibitors. These molecules are often involved in the allosteric regulation of enzymes in the control of metabolism. An example of an enzyme activator working in this way is fructose 2,6-bisphosphate, which activates phosphofructokinase 1 and increases the rate of glycolysis in response to the hormone glucagon. In some cases, when a substrate binds to one catalytic subunit of an enzyme, this can trigger an increase in the substrate affinity as well as catalytic activity in the enzyme's other subunits, and thus the substrate acts as an activator. </div> <div class="col-xs-3 col-sm-2"> <a href="#" class="thumbnail"> <img src="http://commons.wikimedia.org/wiki/Special:FilePath/Phosphofructokinase_6PFK_wpmp.png?width=300" alt="thumbnail" class="img-fluid" /> </a> </div> </div> </div> </section>   <section> <div class="container-xl"> <div class="row"> <div class="table-responsive"> <table class="table table-hover table-sm table-light"> <thead> <tr> <th class="col-xs-3 ">Property</th> <th class="col-xs-9 px-3">Value</th> </tr> </thead> <tbody> <tr class="odd"><td class="col-2"><a class="uri" href="http://dbpedia.org/ontology/abstract">dbo:abstract</a> </td><td class="col-10 text-break"><ul> <li style="display:none;">منشط إنزيمي (بالإنجليزية: Enzyme activator)‏ ويقصد بالمنشطات الانزيمية هي التي تجعل الانزيم في حالة حافزية أكثر وفاعلية دون ان تسهم هي بذاتها في التفاعلات التي تحفزها الانزيمات، فأيونات بعض المعادن مثل الحديد (Fe+2، cu+2،Zn+2، Mn+2، K+1،Mg+2)، تكون ضرورية للغاية لنشاط انزيمات معينة في حين يكون لبعضها الآخر مثل (Pb+2)الرصاص والزئبق Hg+2 والفضة Ag+1 سمية بالغة في جميع الانزيمات تقريبًا. (ar)</li> <li style="display:none;">Els activadors enzimàtics són molècules que s'enllacen amb enzims i n'incrementen la seva activitat. Aquestes molècules sovint estan involucrades en la regulació al·lostèrica dels enims en el control del metabolisme. En oposició als coenzims, els activadors enzimàtics són compostos inorgànics, mentre que tant els coenzims com els activadors són cofactors. Un exemple d'activador enzimàtic és la , que activa la i incrementa la taxa de glicòlisi en resposta a l'hormona insulina. (ca)</li> <li style="display:none;">Als Aktivatoren werden in der Biochemie Verbindungen bezeichnet, welche die Aktivität von Enzymen fördern, das heißt katalytische Reaktionen beschleunigen. Aktivatoren werden auch als positive Effektoren bezeichnet. Negative Effektoren, Hemmstoffe der Enzymaktivität, werden dagegen auch Inhibitoren genannt. Es können physiologische und unphysiologische Effektoren unterschieden werden. Die Bindung an das Enzym kann reversibel oder irreversibel sein. Darüber hinaus wird eine isosterische (Bindung an das aktive Zentrum des Enzyms) von einer allosterischen Aktivierung (Bindung außerhalb des aktiven Zentrums) unterschieden. Ein Beispiel für einen reversiblen Aktivator ist Acetyl-CoA, das die Enzymaktivität der Pyruvat-Carboxylase steigert. (de)</li> <li>Enzyme activators are molecules that bind to enzymes and increase their activity. They are the opposite of enzyme inhibitors. These molecules are often involved in the allosteric regulation of enzymes in the control of metabolism. An example of an enzyme activator working in this way is fructose 2,6-bisphosphate, which activates phosphofructokinase 1 and increases the rate of glycolysis in response to the hormone glucagon. In some cases, when a substrate binds to one catalytic subunit of an enzyme, this can trigger an increase in the substrate affinity as well as catalytic activity in the enzyme's other subunits, and thus the substrate acts as an activator. (en)</li> <li style="display:none;">Un activateur enzymatique est une substance qui se lie à une enzyme et favorise son activité. C'est l'opposé d'un inhibiteur enzymatique. Ce sont des espèces chimiques souvent impliquées dans la régulation allostérique d'enzymes clés du métabolisme. Ainsi, le fructose-2,6-bisphosphate est un activateur de la phosphofructokinase-1 et accélère la glycolyse en réponse à la présence d'insuline. Autre exemple, l'acétyl-CoA est un activateur allostérique de la pyruvate carboxylase. Dans certains cas, le substrat lui-même peut avoir un effet allostérique sur l'ensemble d'une enzyme en se liant simplement à l'une de ses sous-unités, ce qui a pour effet d'accroître l'activité catalytique des autres sous-unités de l'enzyme ainsi que leur affinité pour le substrat. Un activateur peut également être un cofacteur. C'est par exemple le cas d'ions métalliques tels que l'ion chlorure Cl−, activateur de l'amylase salivaire, de l'ion magnésium Mg2+, activateur des kinases, et de l'ion zinc Zn2+, activateur de l'anhydrase carbonique ; certains d'entre eux sont considérés comme deuxième substrat. (fr)</li> <li style="display:none;">효소 활성화제(酵素活性化劑, 영어: enzyme activator)는 효소에 결합하여 효소의 활성을 증가시키는 분자이다. 효소 활성화제는 효소 저해제의 반대 개념이다. 이들 분자는 보통 대사 조절에서 효소의 다른 자리 입체성 조절에 관여한다. 이러한 방식으로 작동하는 효소 활성화제의 예로는 포스포프럭토키네이스-1을 활성화시키고 호르몬인 글루카곤에 반응하여 해당과정의 속도를 증가시키는 과당 2,6-이중인산이 있다. 어떤 경우에는 기질이 효소의 촉매 소단위체에 결합할 때 이는 기질 친화도의 증가와 효소의 다른 소단위체의 촉매 활성을 유발할 수 있으며, 따라서 기질이 활성화제 역할을 한다. (ko)</li> <li style="display:none;">Aktywator enzymatyczny – substancja chemiczna umożliwiająca lub poprawiająca działanie enzymów. Ich działanie polega na odszczepianiu od nieaktywnych proenzymów blokujących grup funkcyjnych (rodników) lub ochronie enzymów przed działaniem różnych czynników chemicznych. (pl)</li> <li style="display:none;">酵素活性化剤（こうそかっせいかざい、英: enzyme activators）は、酵素に結合してそのを高める分子である。それは酵素阻害剤の正反対である。これらの分子は、代謝を制御する酵素のアロステリック調節にしばしば関与する。このように機能する酵素活性化剤の例として、ホルモンのグルカゴンに反応して、を活性化し、解糖速度を増加させるフルクトース2,6-ビスリン酸がある。基質が活性化剤として働く場合があり、酵素の1つの触媒サブユニットに基質が結合すると、これが基質親和性と酵素の他のサブユニットの触媒活性の増加を引き起こす。 (ja)</li> <li style="display:none;">Een activator is in de biochemie een stof die de werking van een enzym in gang zet of versterkt zonder zelf een katalysator te zijn. In tegenstelling tot een co-enzym is een activator een anorganisch molecuul of ion; ook kleine organische moleculen met deze functie noemt men wel activator. Een niet-actief pro-enzym is een voorbeeld van een enzym dat door een activator actief kan worden gemaakt. (nl)</li> <li style="display:none;">Ativadores enzimáticos são moléculas que unem enzimas e aumentam sua atividade. Podem também ser definidos como substâncias, mas que não sejam o catalisador de uma reação enzimática ou uma das substâncias do substrato que aumente a taxa de reação enzimática. Estas moléculas estão frequentemente envolvidas na regulação alostérica de enzimas no controle do metabolismo. Um exemplo de um ativador enzimático atuando neste sentido é a frutose 2,6-bisfosfato, a qual ativa fosfofrutoquinase 1 e aumenta a taxa de glicólise em resposta ao hormônio glucagon. (pt)</li> <li style="display:none;">Enzymaktivatorer är molekyler som binder till enzymer och på så vis ökar deras aktivitet. Dessa molekyler är ofta involverade i allosterisk reglering av enzymer som kontrollerar metabolismen. Ett exempel på en enzymaktivator som fungerar på detta vis är som aktiverar och ökar glykolysens hastighet vid närvaro av glukagon. (sv)</li> <li style="display:none;">酶激活剂是与酶结合并增加其活性的分子。它们与酶抑制剂相反。这些分子通常参与控制代谢的酶的别构调节(Allosteric regulation)。以这种方式起作用的酶激活剂的实例是，可以激活磷酸果糖激酶1，并且响应于激素胰岛素而增加糖酵解的速率。在一些情况下，当底物结合酶的一个催化亚基时，这可以引发底物亲和力的增加以及酶的其他亚单位中的催化活性，因此底物充当活化剂。 (zh)</li> </ul></td></tr><tr class="even"><td class="col-2"><a class="uri" href="http://dbpedia.org/ontology/thumbnail">dbo:thumbnail</a> </td><td class="col-10 text-break"><ul> <li><a class="uri" rel="dbo:thumbnail" resource="http://commons.wikimedia.org/wiki/Special:FilePath/Phosphofructokinase_6PFK_wpmp.png?width=300" href="http://commons.wikimedia.org/wiki/Special:FilePath/Phosphofructokinase_6PFK_wpmp.png?width=300">wiki-commons:Special:FilePath/Phosphofructokinase_6PFK_wpmp.png?width=300</a></li> </ul></td></tr><tr class="odd"><td class="col-2"><a class="uri" href="http://dbpedia.org/ontology/wikiPageID">dbo:wikiPageID</a> </td><td class="col-10 text-break"><ul> <li>11137294 (xsd:integer)</li> </ul></td></tr><tr class="even"><td class="col-2"><a class="uri" 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text-break"><ul> <li style="display:none;">منشط إنزيمي (بالإنجليزية: Enzyme activator)‏ ويقصد بالمنشطات الانزيمية هي التي تجعل الانزيم في حالة حافزية أكثر وفاعلية دون ان تسهم هي بذاتها في التفاعلات التي تحفزها الانزيمات، فأيونات بعض المعادن مثل الحديد (Fe+2، cu+2،Zn+2، Mn+2، K+1،Mg+2)، تكون ضرورية للغاية لنشاط انزيمات معينة في حين يكون لبعضها الآخر مثل (Pb+2)الرصاص والزئبق Hg+2 والفضة Ag+1 سمية بالغة في جميع الانزيمات تقريبًا. (ar)</li> <li style="display:none;">Els activadors enzimàtics són molècules que s'enllacen amb enzims i n'incrementen la seva activitat. Aquestes molècules sovint estan involucrades en la regulació al·lostèrica dels enims en el control del metabolisme. En oposició als coenzims, els activadors enzimàtics són compostos inorgànics, mentre que tant els coenzims com els activadors són cofactors. Un exemple d'activador enzimàtic és la , que activa la i incrementa la taxa de glicòlisi en resposta a l'hormona insulina. (ca)</li> <li>Enzyme activators are molecules that bind to enzymes and increase their activity. They are the opposite of enzyme inhibitors. These molecules are often involved in the allosteric regulation of enzymes in the control of metabolism. An example of an enzyme activator working in this way is fructose 2,6-bisphosphate, which activates phosphofructokinase 1 and increases the rate of glycolysis in response to the hormone glucagon. In some cases, when a substrate binds to one catalytic subunit of an enzyme, this can trigger an increase in the substrate affinity as well as catalytic activity in the enzyme's other subunits, and thus the substrate acts as an activator. (en)</li> <li style="display:none;">효소 활성화제(酵素活性化劑, 영어: enzyme activator)는 효소에 결합하여 효소의 활성을 증가시키는 분자이다. 효소 활성화제는 효소 저해제의 반대 개념이다. 이들 분자는 보통 대사 조절에서 효소의 다른 자리 입체성 조절에 관여한다. 이러한 방식으로 작동하는 효소 활성화제의 예로는 포스포프럭토키네이스-1을 활성화시키고 호르몬인 글루카곤에 반응하여 해당과정의 속도를 증가시키는 과당 2,6-이중인산이 있다. 어떤 경우에는 기질이 효소의 촉매 소단위체에 결합할 때 이는 기질 친화도의 증가와 효소의 다른 소단위체의 촉매 활성을 유발할 수 있으며, 따라서 기질이 활성화제 역할을 한다. (ko)</li> <li style="display:none;">Aktywator enzymatyczny – substancja chemiczna umożliwiająca lub poprawiająca działanie enzymów. Ich działanie polega na odszczepianiu od nieaktywnych proenzymów blokujących grup funkcyjnych (rodników) lub ochronie enzymów przed działaniem różnych czynników chemicznych. (pl)</li> <li style="display:none;">酵素活性化剤（こうそかっせいかざい、英: enzyme activators）は、酵素に結合してそのを高める分子である。それは酵素阻害剤の正反対である。これらの分子は、代謝を制御する酵素のアロステリック調節にしばしば関与する。このように機能する酵素活性化剤の例として、ホルモンのグルカゴンに反応して、を活性化し、解糖速度を増加させるフルクトース2,6-ビスリン酸がある。基質が活性化剤として働く場合があり、酵素の1つの触媒サブユニットに基質が結合すると、これが基質親和性と酵素の他のサブユニットの触媒活性の増加を引き起こす。 (ja)</li> <li style="display:none;">Een activator is in de biochemie een stof die de werking van een enzym in gang zet of versterkt zonder zelf een katalysator te zijn. In tegenstelling tot een co-enzym is een activator een anorganisch molecuul of ion; ook kleine organische moleculen met deze functie noemt men wel activator. Een niet-actief pro-enzym is een voorbeeld van een enzym dat door een activator actief kan worden gemaakt. (nl)</li> <li style="display:none;">Ativadores enzimáticos são moléculas que unem enzimas e aumentam sua atividade. Podem também ser definidos como substâncias, mas que não sejam o catalisador de uma reação enzimática ou uma das substâncias do substrato que aumente a taxa de reação enzimática. Estas moléculas estão frequentemente envolvidas na regulação alostérica de enzimas no controle do metabolismo. Um exemplo de um ativador enzimático atuando neste sentido é a frutose 2,6-bisfosfato, a qual ativa fosfofrutoquinase 1 e aumenta a taxa de glicólise em resposta ao hormônio glucagon. (pt)</li> <li style="display:none;">Enzymaktivatorer är molekyler som binder till enzymer och på så vis ökar deras aktivitet. Dessa molekyler är ofta involverade i allosterisk reglering av enzymer som kontrollerar metabolismen. Ett exempel på en enzymaktivator som fungerar på detta vis är som aktiverar och ökar glykolysens hastighet vid närvaro av glukagon. (sv)</li> <li style="display:none;">酶激活剂是与酶结合并增加其活性的分子。它们与酶抑制剂相反。这些分子通常参与控制代谢的酶的别构调节(Allosteric regulation)。以这种方式起作用的酶激活剂的实例是，可以激活磷酸果糖激酶1，并且响应于激素胰岛素而增加糖酵解的速率。在一些情况下，当底物结合酶的一个催化亚基时，这可以引发底物亲和力的增加以及酶的其他亚单位中的催化活性，因此底物充当活化剂。 (zh)</li> <li style="display:none;">Als Aktivatoren werden in der Biochemie Verbindungen bezeichnet, welche die Aktivität von Enzymen fördern, das heißt katalytische Reaktionen beschleunigen. Aktivatoren werden auch als positive Effektoren bezeichnet. Negative Effektoren, Hemmstoffe der Enzymaktivität, werden dagegen auch Inhibitoren genannt. Es können physiologische und unphysiologische Effektoren unterschieden werden. Die Bindung an das Enzym kann reversibel oder irreversibel sein. Darüber hinaus wird eine isosterische (Bindung an das aktive Zentrum des Enzyms) von einer allosterischen Aktivierung (Bindung außerhalb des aktiven Zentrums) unterschieden. (de)</li> <li style="display:none;">Un activateur enzymatique est une substance qui se lie à une enzyme et favorise son activité. C'est l'opposé d'un inhibiteur enzymatique. Ce sont des espèces chimiques souvent impliquées dans la régulation allostérique d'enzymes clés du métabolisme. Ainsi, le fructose-2,6-bisphosphate est un activateur de la phosphofructokinase-1 et accélère la glycolyse en réponse à la présence d'insuline. Autre exemple, l'acétyl-CoA est un activateur allostérique de la pyruvate carboxylase. (fr)</li> </ul></td></tr><tr class="even"><td class="col-2"><a class="uri" href="http://www.w3.org/2000/01/rdf-schema#label">rdfs:label</a> </td><td class="col-10 text-break"><ul> <li style="display:none;">منشط إنزيمي (ar)</li> <li style="display:none;">Activador enzimàtic (ca)</li> <li style="display:none;">Aktivator (Biochemie) (de)</li> <li>Enzyme activator (en)</li> <li style="display:none;">Activateur enzymatique (fr)</li> <li style="display:none;">효소 활성화제 (ko)</li> <li style="display:none;">酵素活性化剤 (ja)</li> <li style="display:none;">Activator (biochemie) (nl)</li> <li style="display:none;">Aktywator enzymatyczny (pl)</li> <li style="display:none;">Ativador enzimático (pt)</li> <li style="display:none;">Enzymaktivator (sv)</li> <li style="display:none;">酶激活剂 (zh)</li> </ul></td></tr><tr class="odd"><td class="col-2"><a class="uri" href="http://www.w3.org/2002/07/owl#sameAs">owl:sameAs</a> </td><td class="col-10 text-break"><ul> <li><a class="uri" rel="owl:sameAs" 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