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(1)</label></li></ul></fieldset></details></div></div><button type="submit" id="facet-form-submit" style="display:none">Search</button></div></aside><main id="maincontent"><section class="o-columnbox1"><header><h2 class="o-columnbox1__heading" aria-live="polite">Scholarly Works (25 results)</h2></header><div class="c-sortpagination"><div class="c-sort"><div class="o-input__droplist1"><label for="c-sort1">Sort By:</label><select name="sort" id="c-sort1" form="facetForm"><option selected="" value="rel">Relevance</option><option value="a-title">A-Z By Title</option><option value="z-title">Z-A By Title</option><option value="a-author">A-Z By Author</option><option value="z-author">Z-A By Author</option><option value="asc">Date Ascending</option><option value="desc">Date Descending</option></select></div><div class="o-input__droplist1 c-sort__page-input"><label for="c-sort2">Show:</label><select name="rows" id="c-sort2" form="facetForm"><option selected="" value="10">10</option><option value="20">20</option><option value="30">30</option></select></div></div><input type="hidden" name="start" form="facetForm" value="0"/><nav class="c-pagination"><ul><li><a href="" aria-label="you are on result set 1" class="c-pagination__item--current">1</a></li><li><a href="" aria-label="go to result set 2" class="c-pagination__item">2</a></li><li><a href="" aria-label="go to result set 3" class="c-pagination__item">3</a></li></ul></nav></div><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/9sr4q9gk"><div class="c-clientmarkup">Neurobiology of schizophrenia: Search for the elusive correlation with symptoms</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3AMathalon%2C%20DH">Mathalon, DH</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3AFord%2C%20JM">Ford, JM</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucsf_postprints">UC San Francisco Previously Published Works</a> (2012)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup">In the last half-century, human neuroscience methods provided a way to study schizophrenia in vivo, and established that it is associated with subtle abnormalities in brain structure and function. However, efforts to understand the neurobiological bases of the clinical symptoms that the diagnosis is based on have been largely unsuccessful. In this paper, we provide an overview of the conceptual and methodological obstacles that undermine efforts to link the severity of specific symptoms to specific neurobiological measures. These obstacles include small samples, questionable reliability and validity of measurements, medication confounds, failure to distinguish state and trait effects, correlation-causation ambiguity, and the absence of compelling animal models of specific symptoms to test mechanistic hypotheses derived from brain-symptom correlations. We conclude with recommendations to promote progress in establishing brain-symptom relationships. 漏 2012 Mathalon and Ford.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/9sr4q9gk"><img src="/cms-assets/582a0eee90941fa94361d9f0f1fb2e979017eec6f4045bc95bc47bd218e85ec5" alt="Cover page: Neurobiology of schizophrenia: Search for the elusive correlation with symptoms"/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/03q8z0hr"><div class="c-clientmarkup">Neurobiology of schizophrenia: Search for the elusive correlation with symptoms</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3AMathalon%2C%20Daniel">Mathalon, Daniel</a>; </li><li><a href="/search/?q=author%3AMathalon%2C%20DH">Mathalon, DH</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3AFord%2C%20JM">Ford, JM</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucsf_postprints">UC San Francisco Previously Published Works</a> (2012)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup">In the last half-century, human neuroscience methods provided a way to study schizophrenia in vivo, and established that it is associated with subtle abnormalities in brain structure and function. However, efforts to understand the neurobiological bases of</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/8qw0q3cb"><div class="c-clientmarkup">Using concurrent EEG and fMRI to probe the state of the brain in schizophrenia</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3AMathalon%2C%20Daniel">Mathalon, Daniel</a>; </li><li><a href="/search/?q=author%3AFord%2C%20JM">Ford, JM</a>; </li><li><a href="/search/?q=author%3ARoach%2C%20BJ">Roach, BJ</a>; </li><li><a href="/search/?q=author%3APalzes%2C%20VA">Palzes, VA</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3AMathalon%2C%20DH">Mathalon, DH</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucsf_postprints">UC San Francisco Previously Published Works</a> (2016)</div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/4xb2j9xj"><div class="c-clientmarkup">Chapter 11 Converging evidence for gamma synchrony deficits in schizophrenia</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3ARoach%2C%20BJ">Roach, BJ</a>; </li><li><a href="/search/?q=author%3AFord%2C%20JM">Ford, JM</a>; </li><li><a href="/search/?q=author%3AHoffman%2C%20RE">Hoffman, RE</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3AMathalon%2C%20DH">Mathalon, DH</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucsf_postprints">UC San Francisco Previously Published Works</a> (2013)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup"><h3>Background</h3>In electroencephalogram (EEG) studies of auditory steady-state responses (ASSRs), patients with schizophrenia show a deficit in power and/or phase-locking, particularly at the 40 Hz frequency where these responses resonate. In addition, studies of the transient gamma-band response (GBR) elicited by single tones have revealed deficits in gamma power and phase-locking in schizophrenia. We examined the degree to which the 40 Hz ASSR and the transient GBR to single tones are correlated and whether they assess overlapping or distinct gamma-band abnormalities in schizophrenia.<h3>Methods</h3>EEG was recorded during 40 Hz ASSR and auditory oddball paradigms from 28 patients with schizophrenia or schizoaffective disorder (SZ) and 25 age- and gender-matched healthy controls (HC). The ASSR was elicited by 500 ms click trains, and the transient GBR was elicited by the standard tones from the oddball paradigm. Gamma phase and magnitude values, calculated using Morlet wavelet transformations, were used to derive total power and phase-locking measures.<h3>Results</h3>Relative to HC, SZ patients had significant deficits in total gamma power and phase-locking for both ASSR- and GBR-based measures. Within both groups, the 40 Hz ASSR and GBR phase-locking measures were significantly correlated, with a similar trend evident for the total power measures. Moreover, co-varying for GBR substantially reduced 40 Hz ASSR power and phase-locking differences between the groups.<h3>Conclusions</h3>40 Hz ASSR and transient GBR measures provide very similar information about auditory gamma abnormalities in schizophrenia, despite the overall enhancement of 40 Hz ASSR total power and phase-locking values relative to the corresponding GBR values.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/4xb2j9xj"><img src="/cms-assets/5d93141b52440cd0a87e2674795db43a923cabe606c2001809bf06c84faf27bd" alt="Cover page: Chapter 11 Converging evidence for gamma synchrony deficits in schizophrenia"/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/33p084k7"><div class="c-clientmarkup">Oxytocin administration selectively improves olfactory detection thresholds for lyral in patients with schizophrenia.</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3AWoolley%2C%20JD">Woolley, JD</a>; </li><li><a href="/search/?q=author%3ALam%2C%20O">Lam, O</a>; </li><li><a href="/search/?q=author%3AChuang%2C%20B">Chuang, B</a>; </li><li><a href="/search/?q=author%3AFord%2C%20JM">Ford, JM</a>; </li><li><a href="/search/?q=author%3AMathalon%2C%20DH">Mathalon, DH</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3AVinogradov%2C%20S">Vinogradov, S</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucsf_postprints">UC San Francisco Previously Published Works</a> (2015)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup"><h3>Background</h3>Olfaction plays an important role in mammalian social behavior. Olfactory deficits are common in schizophrenia and correlate with negative symptoms and low social drive. Despite their prominence and possible clinical relevance, little is understood about the pathological mechanisms underlying olfactory deficits in schizophrenia and there are currently no effective treatments for these deficits. The prosocial neuropeptide oxytocin may affect the olfactory system when administered intranasally to humans and there is growing interest in its therapeutic potential in schizophrenia.<h3>Methods</h3>To examine this model, we administered 40IU of oxytocin and placebo intranasally to 31 patients with a schizophrenia spectrum illness and 34 age-matched healthy control participants in a randomized, double-blind, placebo-controlled, cross-over study. On each test day, participants completed an olfactory detection threshold test for two different odors: (1) lyral, a synthetic fragrance compound for which patients with schizophrenia have specific olfactory detection threshold deficits, possibly related to decreased cyclic adenosine 3',5'-monophosphate (cAMP) signaling; and (2) anise, a compound for which olfactory detection thresholds change with menstrual cycle phase in women.<h3>Results</h3>On the placebo test day, patients with schizophrenia did not significantly differ from healthy controls in detection of either odor. We found that oxytocin administration significantly and selectively improved olfactory detection thresholds for lyral but not for anise in patients with schizophrenia. In contrast, oxytocin had no effect on detection of either odor in healthy controls.<h3>Discussion</h3>Our data indicate that oxytocin administration may ameliorate olfactory deficits in schizophrenia and suggest the effects of intranasal oxytocin may extend to influencing the olfactory system. Given that oxytocin has been found to increase cAMP signaling in vitro a possible mechanism for these effects is discussed.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/33p084k7"><img src="/cms-assets/3aa2285fdda7350c23f239cebb22f0c1fce8770efbc78e045ac37393b3ab0935" alt="Cover page: Oxytocin administration selectively improves olfactory detection thresholds for lyral in patients with schizophrenia."/></a><a href="https://creativecommons.org/licenses/by/4.0/" class="c-scholworks__license"><img class="c-lazyimage" data-src="/images/cc-by-small.svg" alt="Creative Commons 'BY' version 4.0 license"/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/1xv098pj"><div class="c-clientmarkup">Intranasal oxytocin increases facial expressivity, but not ratings of trustworthiness, in patients with schizophrenia and healthy controls</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3AWoolley%2C%20JD">Woolley, JD</a>; </li><li><a href="/search/?q=author%3AChuang%2C%20B">Chuang, B</a>; </li><li><a href="/search/?q=author%3AFussell%2C%20C">Fussell, C</a>; </li><li><a href="/search/?q=author%3AScherer%2C%20S">Scherer, S</a>; </li><li><a href="/search/?q=author%3ABiagianti%2C%20B">Biagianti, B</a>; </li><li><a href="/search/?q=author%3AFulford%2C%20D">Fulford, D</a>; </li><li><a href="/search/?q=author%3AMathalon%2C%20DH">Mathalon, DH</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3AVinogradov%2C%20S">Vinogradov, S</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucsf_postprints">UC San Francisco Previously Published Works</a> (2017)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup"><h3>Background</h3>Blunted facial affect is a common negative symptom of schizophrenia. Additionally, assessing the trustworthiness of faces is a social cognitive ability that is impaired in schizophrenia. Currently available pharmacological agents are ineffective at improving either of these symptoms, despite their clinical significance. The hypothalamic neuropeptide oxytocin has multiple prosocial effects when administered intranasally to healthy individuals and shows promise in decreasing negative symptoms and enhancing social cognition in schizophrenia. Although two small studies have investigated oxytocin's effects on ratings of facial trustworthiness in schizophrenia, its effects on facial expressivity have not been investigated in any population.<h3>Method</h3>We investigated the effects of oxytocin on facial emotional expressivity while participants performed a facial trustworthiness rating task in 33 individuals with schizophrenia and 35 age-matched healthy controls using a double-blind, placebo-controlled, cross-over design. Participants rated the trustworthiness of presented faces interspersed with emotionally evocative photographs while being video-recorded. Participants' facial expressivity in these videos was quantified by blind raters using a well-validated manualized approach (i.e. the Facial Expression Coding System; FACES).<h3>Results</h3>While oxytocin administration did not affect ratings of facial trustworthiness, it significantly increased facial expressivity in individuals with schizophrenia (Z = -2.33, p = 0.02) and at trend level in healthy controls (Z = -1.87, p = 0.06).<h3>Conclusions</h3>These results demonstrate that oxytocin administration can increase facial expressivity in response to emotional stimuli and suggest that oxytocin may have the potential to serve as a treatment for blunted facial affect in schizophrenia.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/1xv098pj"><img src="/cms-assets/0dcf3c3604bc7fd92c446882cef03400d0540ef661282f3be48e11f56db03738" alt="Cover page: Intranasal oxytocin increases facial expressivity, but not ratings of trustworthiness, in patients with schizophrenia and healthy controls"/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/09w2340x"><div class="c-clientmarkup">Error-related brain activity dissociates hoarding disorder from obsessive-compulsive disorder.</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3AMathews%2C%20CA">Mathews, CA</a>; </li><li><a href="/search/?q=author%3APerez%2C%20VB">Perez, VB</a>; </li><li><a href="/search/?q=author%3ARoach%2C%20BJ">Roach, BJ</a>; </li><li><a href="/search/?q=author%3AFekri%2C%20S">Fekri, S</a>; </li><li><a href="/search/?q=author%3AVigil%2C%20O">Vigil, O</a>; </li><li><a href="/search/?q=author%3AKupferman%2C%20E">Kupferman, E</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3AMathalon%2C%20DH">Mathalon, DH</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucsf_postprints">UC San Francisco Previously Published Works</a> (2016)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup"><h3>Background</h3>Obsessive-compulsive disorder (OCD) is associated with an abnormally large error-related negativity (ERN), an electrophysiological measure of error monitoring in response to performance errors, but it is unclear if hoarding disorder (HD) also shows this abnormality. This study aimed to determine whether the neurophysiological mechanisms underlying error monitoring are similarly compromised in HD and OCD.<h3>Method</h3>We used a visual flanker task to assess ERN in response to performance errors in 14 individuals with HD, 27 with OCD, 10 with HD+OCD, and 45 healthy controls (HC). Age-corrected performance and ERN amplitudes were examined using analyses of variance and planned pairwise group comparisons.<h3>Results</h3>A main effect of hoarding on ERN (p = 0.031) was observed, indicating ERN amplitudes were attenuated in HD relative to non-HD subjects. A group 脳 age interaction effect on ERN was also evident. In HD-positive subjects, ERN amplitude deficits were significantly greater in younger individuals (r = -0.479, p = 0.018), whereas there were no significant ERN changes with increasing age in OCD and HC participants.<h3>Conclusions</h3>The reduced ERN in HD relative to OCD and HC provides evidence that HD is neurobiologically distinct from OCD, and suggests that deficient error monitoring may be a core pathophysiological feature of HD. This effect was particularly prominent in younger HD participants, further suggesting that deficient error monitoring manifests most strongly early in the illness course and/or in individuals with a relatively early illness onset.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/09w2340x"><img src="/cms-assets/cc7d753a6a96a179e006618b9befb8bf422f8872b2fed38217cdabd4a5eb5551" alt="Cover page: Error-related brain activity dissociates hoarding disorder from obsessive-compulsive disorder."/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/64h13250"><div class="c-clientmarkup">Corrigendum to "Oxytocin administration enhances controlled social cognition in patients with schizophrenia" [Psychoneuroendocrinology 47 (2014) 116-125].</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3AWoolley%2C%20JD">Woolley, JD</a>; </li><li><a href="/search/?q=author%3AChuang%2C%20B">Chuang, B</a>; </li><li><a href="/search/?q=author%3ALam%2C%20O">Lam, O</a>; </li><li><a href="/search/?q=author%3ALai%2C%20W">Lai, W</a>; </li><li><a href="/search/?q=author%3AO'Donovan%2C%20A">O'Donovan, A</a>; </li><li><a href="/search/?q=author%3ARankin%2C%20KP">Rankin, KP</a>; </li><li><a href="/search/?q=author%3AMathalon%2C%20DH">Mathalon, DH</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3AVinogradov%2C%20S">Vinogradov, S</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucsf_postprints">UC San Francisco Previously Published Works</a> (2014)</div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/64h13250"><img src="/cms-assets/e09822de16adcc9d5d7afc123bbbf5933322d47fb0a53e4e5ca715ab647a5168" alt="Cover page: Corrigendum to "Oxytocin administration enhances controlled social cognition in patients with schizophrenia" [Psychoneuroendocrinology 47 (2014) 116-125]."/></a><a href="https://creativecommons.org/licenses/by/4.0/" class="c-scholworks__license"><img class="c-lazyimage" data-src="/images/cc-by-small.svg" alt="Creative Commons 'BY' version 4.0 license"/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/154462sr"><div class="c-clientmarkup">Neural Mechanisms of Positive Mood Induced Modulation of Reality Monitoring</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3AMathalon%2C%20Daniel">Mathalon, Daniel</a>; </li><li><a href="/search/?q=author%3ASubramaniam%2C%20K">Subramaniam, K</a>; </li><li><a href="/search/?q=author%3AGill%2C%20J">Gill, J</a>; </li><li><a href="/search/?q=author%3ASlattery%2C%20P">Slattery, P</a>; </li><li><a href="/search/?q=author%3AShastri%2C%20A">Shastri, A</a>; </li><li><a href="/search/?q=author%3AMathalon%2C%20DH">Mathalon, DH</a>; </li><li><a href="/search/?q=author%3ANagarajan%2C%20S">Nagarajan, S</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3AVinogradov%2C%20S">Vinogradov, S</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucsf_postprints">UC San Francisco Previously Published Works</a> (2016)</div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/76t0q33c"><div class="c-clientmarkup">Oxytocin administration enhances controlled social cognition in patients with schizophrenia.</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3AWoolley%2C%20JD">Woolley, JD</a>; </li><li><a href="/search/?q=author%3AChuang%2C%20B">Chuang, B</a>; </li><li><a href="/search/?q=author%3ALam%2C%20O">Lam, O</a>; </li><li><a href="/search/?q=author%3ALai%2C%20W">Lai, W</a>; </li><li><a href="/search/?q=author%3AO'Donovan%2C%20A">O'Donovan, A</a>; </li><li><a href="/search/?q=author%3ARankin%2C%20KP">Rankin, KP</a>; </li><li><a href="/search/?q=author%3AMathalon%2C%20DH">Mathalon, DH</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3AVinogradov%2C%20S">Vinogradov, S</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucsf_postprints">UC San Francisco Previously Published Works</a> (2014)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup"><h3>Background</h3>Individuals with schizophrenia have functionally significant deficits in automatic and controlled social cognition, but no currently available pharmacologic treatments reduce these deficits. The neuropeptide oxytocin has multiple prosocial effects when administered intranasally in humans and there is growing interest in its therapeutic potential in schizophrenia.<h3>Methods</h3>We administered 40 IU of oxytocin and saline placebo intranasally to 29 male subjects with schizophrenia and 31 age-matched, healthy controls in a randomized, double-blind, placebo-controlled, cross-over study. Social cognition was assessed with The Awareness of Social Inference Test (TASIT) and the Reading the Mind in the Eyes Test (RMET). We examined the effects of oxytocin administration on automatic social cognition (the ability to rapidly interpret and understand emotional cues from the voice, face, and body); controlled social cognition (the ability to comprehend indirectly expressed emotions, thoughts, and intentions through complex deliberations over longer time periods); and a control task (the ability to comprehend truthful dialog and perform general task procedures) in individuals with and without schizophrenia using mixed factorial analysis of variance models.<h3>Results</h3>Patients with schizophrenia showed significant impairments in automatic and controlled social cognition compared to healthy controls, and administration of oxytocin significantly improved their controlled, but not automatic, social cognition, F(1, 58)=8.75; p=0.004. Conversely, oxytocin administration had limited effects on social cognition in healthy participants. Patients and controls performed equally well and there were no effects of oxytocin administration on the control task.<h3>Discussion</h3>Intact social cognitive abilities are associated with better functional outcomes in individuals with schizophrenia. Our data highlight the potentially complex effects of oxytocin on some but not all aspects of social cognition, and support the exploration of intranasal oxytocin as a potential adjunct treatment to improve controlled social cognition in schizophrenia.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/76t0q33c"><img src="/cms-assets/871271f27f8a13d36acf1bc1feebfd1b05ee749656dbd7fb7ca85e0f8f252b78" alt="Cover page: Oxytocin administration enhances controlled social cognition in patients with schizophrenia."/></a><a href="https://creativecommons.org/licenses/by/4.0/" class="c-scholworks__license"><img class="c-lazyimage" data-src="/images/cc-by-small.svg" alt="Creative Commons 'BY' version 4.0 license"/></a></div></section><nav class="c-pagination"><ul><li><a href="" aria-label="you are on result set 1" class="c-pagination__item--current">1</a></li><li><a href="" 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correlation with symptoms","abstract":"In the last half-century, human neuroscience methods provided a way to study schizophrenia in vivo, and established that it is associated with subtle abnormalities in brain structure and function. However, efforts to understand the neurobiological bases of the clinical symptoms that the diagnosis is based on have been largely unsuccessful. In this paper, we provide an overview of the conceptual and methodological obstacles that undermine efforts to link the severity of specific symptoms to specific neurobiological measures. These obstacles include small samples, questionable reliability and validity of measurements, medication confounds, failure to distinguish state and trait effects, correlation-causation ambiguity, and the absence of compelling animal models of specific symptoms to test mechanistic hypotheses derived from brain-symptom correlations. We conclude with recommendations to promote progress in establishing brain-symptom relationships. \u00A9 2012 Mathalon and Ford.","content_type":"application/pdf","author_hide":null,"authors":[{"name":"Mathalon, DH","email":"daniel.mathalon@ucsf.edu","fname":"DH","lname":"Mathalon","ORCID_id":"0000-0001-6090-4974"},{"name":"Ford, JM","fname":"JM","lname":"Ford"}],"supp_files":[{"type":"pdf","count":0},{"type":"image","count":0},{"type":"video","count":0},{"type":"audio","count":0},{"type":"zip","count":0},{"type":"other","count":0}],"thumbnail":{"width":121,"height":174,"asset_id":"582a0eee90941fa94361d9f0f1fb2e979017eec6f4045bc95bc47bd218e85ec5","timestamp":1439920342,"image_type":"png"},"pub_year":2012,"genre":"article","rights":null,"peerReviewed":true,"unitInfo":{"displayName":"UC San Francisco Previously Published Works","link_path":"ucsf_postprints"}},{"id":"qt03q8z0hr","title":"Neurobiology of schizophrenia: Search for the elusive correlation with symptoms","abstract":"In the last half-century, human neuroscience methods provided a way to study schizophrenia in vivo, and established that it is associated with subtle abnormalities in brain structure and function. However, efforts to understand the neurobiological bases of","content_type":null,"author_hide":null,"authors":[{"name":"Mathalon, Daniel","email":"Daniel.Mathalon@ucsf.edu","fname":"Daniel","lname":"Mathalon","institution":"UCSF"},{"name":"Mathalon, DH","fname":"DH","lname":"Mathalon"},{"name":"Ford, JM","fname":"JM","lname":"Ford"}],"supp_files":[{"type":"pdf","count":0},{"type":"image","count":0},{"type":"video","count":0},{"type":"audio","count":0},{"type":"zip","count":0},{"type":"other","count":0}],"thumbnail":null,"pub_year":2012,"genre":"article","rights":null,"peerReviewed":true,"unitInfo":{"displayName":"UC San Francisco Previously Published Works","link_path":"ucsf_postprints"}},{"id":"qt8qw0q3cb","title":"Using concurrent EEG and fMRI to probe the state of the brain in schizophrenia","abstract":null,"content_type":null,"author_hide":null,"authors":[{"name":"Mathalon, Daniel","email":"Daniel.Mathalon@ucsf.edu","fname":"Daniel","lname":"Mathalon","institution":"UCSF"},{"name":"Ford, JM","fname":"JM","lname":"Ford"},{"name":"Roach, BJ","fname":"BJ","lname":"Roach"},{"name":"Palzes, VA","fname":"VA","lname":"Palzes"},{"name":"Mathalon, DH","fname":"DH","lname":"Mathalon"}],"supp_files":[{"type":"pdf","count":0},{"type":"image","count":0},{"type":"video","count":0},{"type":"audio","count":0},{"type":"zip","count":0},{"type":"other","count":0}],"thumbnail":null,"pub_year":2016,"genre":"article","rights":null,"peerReviewed":true,"unitInfo":{"displayName":"UC San Francisco Previously Published Works","link_path":"ucsf_postprints"}},{"id":"qt4xb2j9xj","title":"Chapter 11 Converging evidence for gamma synchrony deficits in schizophrenia","abstract":"<h4>Background</h4>In electroencephalogram (EEG) studies of auditory steady-state responses (ASSRs), patients with schizophrenia show a deficit in power and/or phase-locking, particularly at the 40 Hz frequency where these responses resonate. In addition, studies of the transient gamma-band response (GBR) elicited by single tones have revealed deficits in gamma power and phase-locking in schizophrenia. We examined the degree to which the 40 Hz ASSR and the transient GBR to single tones are correlated and whether they assess overlapping or distinct gamma-band abnormalities in schizophrenia.<h4>Methods</h4>EEG was recorded during 40 Hz ASSR and auditory oddball paradigms from 28 patients with schizophrenia or schizoaffective disorder (SZ) and 25 age- and gender-matched healthy controls (HC). The ASSR was elicited by 500 ms click trains, and the transient GBR was elicited by the standard tones from the oddball paradigm. Gamma phase and magnitude values, calculated using Morlet wavelet transformations, were used to derive total power and phase-locking measures.<h4>Results</h4>Relative to HC, SZ patients had significant deficits in total gamma power and phase-locking for both ASSR- and GBR-based measures. Within both groups, the 40 Hz ASSR and GBR phase-locking measures were significantly correlated, with a similar trend evident for the total power measures. Moreover, co-varying for GBR substantially reduced 40 Hz ASSR power and phase-locking differences between the groups.<h4>Conclusions</h4>40 Hz ASSR and transient GBR measures provide very similar information about auditory gamma abnormalities in schizophrenia, despite the overall enhancement of 40 Hz ASSR total power and phase-locking values relative to the corresponding GBR values.","content_type":"application/pdf","author_hide":null,"authors":[{"name":"Roach, BJ","fname":"BJ","lname":"Roach"},{"name":"Ford, JM","fname":"JM","lname":"Ford"},{"name":"Hoffman, RE","fname":"RE","lname":"Hoffman"},{"name":"Mathalon, DH","email":"daniel.mathalon@ucsf.edu","fname":"DH","lname":"Mathalon","ORCID_id":"0000-0001-6090-4974"}],"supp_files":[{"type":"pdf","count":0},{"type":"image","count":0},{"type":"video","count":0},{"type":"audio","count":0},{"type":"zip","count":0},{"type":"other","count":0}],"thumbnail":{"width":121,"height":149,"asset_id":"5d93141b52440cd0a87e2674795db43a923cabe606c2001809bf06c84faf27bd","timestamp":1680543776,"image_type":"png"},"pub_year":2013,"genre":"article","rights":null,"peerReviewed":true,"unitInfo":{"displayName":"UC San Francisco Previously Published Works","link_path":"ucsf_postprints"}},{"id":"qt33p084k7","title":"Oxytocin administration selectively improves olfactory detection thresholds for lyral in patients with schizophrenia.","abstract":"<h4>Background</h4>Olfaction plays an important role in mammalian social behavior. Olfactory deficits are common in schizophrenia and correlate with negative symptoms and low social drive. Despite their prominence and possible clinical relevance, little is understood about the pathological mechanisms underlying olfactory deficits in schizophrenia and there are currently no effective treatments for these deficits. The prosocial neuropeptide oxytocin may affect the olfactory system when administered intranasally to humans and there is growing interest in its therapeutic potential in schizophrenia.<h4>Methods</h4>To examine this model, we administered 40IU of oxytocin and placebo intranasally to 31 patients with a schizophrenia spectrum illness and 34 age-matched healthy control participants in a randomized, double-blind, placebo-controlled, cross-over study. On each test day, participants completed an olfactory detection threshold test for two different odors: (1) lyral, a synthetic fragrance compound for which patients with schizophrenia have specific olfactory detection threshold deficits, possibly related to decreased cyclic adenosine 3',5'-monophosphate (cAMP) signaling; and (2) anise, a compound for which olfactory detection thresholds change with menstrual cycle phase in women.<h4>Results</h4>On the placebo test day, patients with schizophrenia did not significantly differ from healthy controls in detection of either odor. We found that oxytocin administration significantly and selectively improved olfactory detection thresholds for lyral but not for anise in patients with schizophrenia. In contrast, oxytocin had no effect on detection of either odor in healthy controls.<h4>Discussion</h4>Our data indicate that oxytocin administration may ameliorate olfactory deficits in schizophrenia and suggest the effects of intranasal oxytocin may extend to influencing the olfactory system. Given that oxytocin has been found to increase cAMP signaling in vitro a possible mechanism for these effects is discussed.","content_type":"application/pdf","author_hide":null,"authors":[{"name":"Woolley, JD","email":"josh.woolley@ucsf.edu","fname":"JD","lname":"Woolley","ORCID_id":"0000-0002-4378-0014"},{"name":"Lam, O","fname":"O","lname":"Lam"},{"name":"Chuang, B","fname":"B","lname":"Chuang"},{"name":"Ford, JM","fname":"JM","lname":"Ford"},{"name":"Mathalon, DH","email":"daniel.mathalon@ucsf.edu","fname":"DH","lname":"Mathalon","ORCID_id":"0000-0001-6090-4974"},{"name":"Vinogradov, S","fname":"S","lname":"Vinogradov"}],"supp_files":[{"type":"pdf","count":0},{"type":"image","count":0},{"type":"video","count":0},{"type":"audio","count":0},{"type":"zip","count":0},{"type":"other","count":0}],"thumbnail":{"width":121,"height":167,"asset_id":"3aa2285fdda7350c23f239cebb22f0c1fce8770efbc78e045ac37393b3ab0935","timestamp":1427927732,"image_type":"jpeg"},"pub_year":2015,"genre":"article","rights":"https://creativecommons.org/licenses/by/4.0/","peerReviewed":true,"unitInfo":{"displayName":"UC San Francisco Previously Published Works","link_path":"ucsf_postprints"}},{"id":"qt1xv098pj","title":"Intranasal oxytocin increases facial expressivity, but not ratings of trustworthiness, in patients with schizophrenia and healthy controls","abstract":"<h4>Background</h4>Blunted facial affect is a common negative symptom of schizophrenia. Additionally, assessing the trustworthiness of faces is a social cognitive ability that is impaired in schizophrenia. Currently available pharmacological agents are ineffective at improving either of these symptoms, despite their clinical significance. The hypothalamic neuropeptide oxytocin has multiple prosocial effects when administered intranasally to healthy individuals and shows promise in decreasing negative symptoms and enhancing social cognition in schizophrenia. Although two small studies have investigated oxytocin's effects on ratings of facial trustworthiness in schizophrenia, its effects on facial expressivity have not been investigated in any population.<h4>Method</h4>We investigated the effects of oxytocin on facial emotional expressivity while participants performed a facial trustworthiness rating task in 33 individuals with schizophrenia and 35 age-matched healthy controls using a double-blind, placebo-controlled, cross-over design. Participants rated the trustworthiness of presented faces interspersed with emotionally evocative photographs while being video-recorded. Participants' facial expressivity in these videos was quantified by blind raters using a well-validated manualized approach (i.e. the Facial Expression Coding System; FACES).<h4>Results</h4>While oxytocin administration did not affect ratings of facial trustworthiness, it significantly increased facial expressivity in individuals with schizophrenia (Z = -2.33, p = 0.02) and at trend level in healthy controls (Z = -1.87, p = 0.06).<h4>Conclusions</h4>These results demonstrate that oxytocin administration can increase facial expressivity in response to emotional stimuli and suggest that oxytocin may have the potential to serve as a treatment for blunted facial affect in schizophrenia.","content_type":"application/pdf","author_hide":null,"authors":[{"name":"Woolley, JD","email":"josh.woolley@ucsf.edu","fname":"JD","lname":"Woolley","ORCID_id":"0000-0002-4378-0014"},{"name":"Chuang, B","fname":"B","lname":"Chuang"},{"name":"Fussell, C","fname":"C","lname":"Fussell"},{"name":"Scherer, S","fname":"S","lname":"Scherer"},{"name":"Biagianti, B","fname":"B","lname":"Biagianti"},{"name":"Fulford, D","fname":"D","lname":"Fulford"},{"name":"Mathalon, DH","email":"daniel.mathalon@ucsf.edu","fname":"DH","lname":"Mathalon","ORCID_id":"0000-0001-6090-4974"},{"name":"Vinogradov, S","fname":"S","lname":"Vinogradov"}],"supp_files":[{"type":"pdf","count":0},{"type":"image","count":0},{"type":"video","count":0},{"type":"audio","count":0},{"type":"zip","count":0},{"type":"other","count":0}],"thumbnail":{"width":121,"height":159,"asset_id":"0dcf3c3604bc7fd92c446882cef03400d0540ef661282f3be48e11f56db03738","timestamp":1683672268,"image_type":"png"},"pub_year":2017,"genre":"article","rights":null,"peerReviewed":true,"unitInfo":{"displayName":"UC San Francisco Previously Published Works","link_path":"ucsf_postprints"}},{"id":"qt09w2340x","title":"Error-related brain activity dissociates hoarding disorder from obsessive-compulsive disorder.","abstract":"<h4>Background</h4>Obsessive-compulsive disorder (OCD) is associated with an abnormally large error-related negativity (ERN), an electrophysiological measure of error monitoring in response to performance errors, but it is unclear if hoarding disorder (HD) also shows this abnormality. This study aimed to determine whether the neurophysiological mechanisms underlying error monitoring are similarly compromised in HD and OCD.<h4>Method</h4>We used a visual flanker task to assess ERN in response to performance errors in 14 individuals with HD, 27 with OCD, 10 with HD+OCD, and 45 healthy controls (HC). Age-corrected performance and ERN amplitudes were examined using analyses of variance and planned pairwise group comparisons.<h4>Results</h4>A main effect of hoarding on ERN (p = 0.031) was observed, indicating ERN amplitudes were attenuated in HD relative to non-HD subjects. A group \u00D7 age interaction effect on ERN was also evident. In HD-positive subjects, ERN amplitude deficits were significantly greater in younger individuals (r = -0.479, p = 0.018), whereas there were no significant ERN changes with increasing age in OCD and HC participants.<h4>Conclusions</h4>The reduced ERN in HD relative to OCD and HC provides evidence that HD is neurobiologically distinct from OCD, and suggests that deficient error monitoring may be a core pathophysiological feature of HD. This effect was particularly prominent in younger HD participants, further suggesting that deficient error monitoring manifests most strongly early in the illness course and/or in individuals with a relatively early illness onset.","content_type":"application/pdf","author_hide":null,"authors":[{"name":"Mathews, CA","email":"carol.mathews@ucsf.edu","fname":"CA","lname":"Mathews"},{"name":"Perez, VB","fname":"VB","lname":"Perez"},{"name":"Roach, BJ","fname":"BJ","lname":"Roach","ORCID_id":"0000-0002-3264-1465"},{"name":"Fekri, S","fname":"S","lname":"Fekri"},{"name":"Vigil, O","fname":"O","lname":"Vigil"},{"name":"Kupferman, E","fname":"E","lname":"Kupferman"},{"name":"Mathalon, DH","email":"daniel.mathalon@ucsf.edu","fname":"DH","lname":"Mathalon","ORCID_id":"0000-0001-6090-4974"}],"supp_files":[{"type":"pdf","count":0},{"type":"image","count":0},{"type":"video","count":0},{"type":"audio","count":0},{"type":"zip","count":0},{"type":"other","count":0}],"thumbnail":{"width":121,"height":149,"asset_id":"cc7d753a6a96a179e006618b9befb8bf422f8872b2fed38217cdabd4a5eb5551","timestamp":1682036830,"image_type":"png"},"pub_year":2016,"genre":"article","rights":null,"peerReviewed":true,"unitInfo":{"displayName":"UC San Francisco Previously Published Works","link_path":"ucsf_postprints"}},{"id":"qt64h13250","title":"Corrigendum to \"Oxytocin administration enhances controlled social cognition in patients with schizophrenia\" [Psychoneuroendocrinology 47 (2014) 116-125].","abstract":null,"content_type":"application/pdf","author_hide":null,"authors":[{"name":"Woolley, JD","email":"josh.woolley@ucsf.edu","fname":"JD","lname":"Woolley","ORCID_id":"0000-0002-4378-0014"},{"name":"Chuang, B","fname":"B","lname":"Chuang"},{"name":"Lam, O","fname":"O","lname":"Lam"},{"name":"Lai, W","fname":"W","lname":"Lai"},{"name":"O'Donovan, A","fname":"A","lname":"O'Donovan"},{"name":"Rankin, KP","email":"kate.rankin@ucsf.edu","fname":"KP","lname":"Rankin"},{"name":"Mathalon, DH","email":"daniel.mathalon@ucsf.edu","fname":"DH","lname":"Mathalon","ORCID_id":"0000-0001-6090-4974"},{"name":"Vinogradov, S","fname":"S","lname":"Vinogradov"}],"supp_files":[{"type":"pdf","count":0},{"type":"image","count":0},{"type":"video","count":0},{"type":"audio","count":0},{"type":"zip","count":0},{"type":"other","count":0}],"thumbnail":{"width":121,"height":166,"asset_id":"e09822de16adcc9d5d7afc123bbbf5933322d47fb0a53e4e5ca715ab647a5168","timestamp":1427928034,"image_type":"jpeg"},"pub_year":2014,"genre":"article","rights":"https://creativecommons.org/licenses/by/4.0/","peerReviewed":true,"unitInfo":{"displayName":"UC San Francisco Previously Published Works","link_path":"ucsf_postprints"}},{"id":"qt154462sr","title":"Neural Mechanisms of Positive Mood Induced Modulation of Reality Monitoring","abstract":null,"content_type":null,"author_hide":null,"authors":[{"name":"Mathalon, Daniel","email":"Daniel.Mathalon@ucsf.edu","fname":"Daniel","lname":"Mathalon","institution":"UCSF"},{"name":"Subramaniam, K","fname":"K","lname":"Subramaniam"},{"name":"Gill, J","fname":"J","lname":"Gill"},{"name":"Slattery, P","fname":"P","lname":"Slattery"},{"name":"Shastri, A","fname":"A","lname":"Shastri"},{"name":"Mathalon, DH","fname":"DH","lname":"Mathalon"},{"name":"Nagarajan, S","fname":"S","lname":"Nagarajan"},{"name":"Vinogradov, S","fname":"S","lname":"Vinogradov"}],"supp_files":[{"type":"pdf","count":0},{"type":"image","count":0},{"type":"video","count":0},{"type":"audio","count":0},{"type":"zip","count":0},{"type":"other","count":0}],"thumbnail":null,"pub_year":2016,"genre":"article","rights":null,"peerReviewed":true,"unitInfo":{"displayName":"UC San Francisco Previously Published Works","link_path":"ucsf_postprints"}},{"id":"qt76t0q33c","title":"Oxytocin administration enhances controlled social cognition in patients with schizophrenia.","abstract":"<h4>Background</h4>Individuals with schizophrenia have functionally significant deficits in automatic and controlled social cognition, but no currently available pharmacologic treatments reduce these deficits. The neuropeptide oxytocin has multiple prosocial effects when administered intranasally in humans and there is growing interest in its therapeutic potential in schizophrenia.<h4>Methods</h4>We administered 40 IU of oxytocin and saline placebo intranasally to 29 male subjects with schizophrenia and 31 age-matched, healthy controls in a randomized, double-blind, placebo-controlled, cross-over study. Social cognition was assessed with The Awareness of Social Inference Test (TASIT) and the Reading the Mind in the Eyes Test (RMET). We examined the effects of oxytocin administration on automatic social cognition (the ability to rapidly interpret and understand emotional cues from the voice, face, and body); controlled social cognition (the ability to comprehend indirectly expressed emotions, thoughts, and intentions through complex deliberations over longer time periods); and a control task (the ability to comprehend truthful dialog and perform general task procedures) in individuals with and without schizophrenia using mixed factorial analysis of variance models.<h4>Results</h4>Patients with schizophrenia showed significant impairments in automatic and controlled social cognition compared to healthy controls, and administration of oxytocin significantly improved their controlled, but not automatic, social cognition, F(1, 58)=8.75; p=0.004. Conversely, oxytocin administration had limited effects on social cognition in healthy participants. Patients and controls performed equally well and there were no effects of oxytocin administration on the control task.<h4>Discussion</h4>Intact social cognitive abilities are associated with better functional outcomes in individuals with schizophrenia. Our data highlight the potentially complex effects of oxytocin on some but not all aspects of social cognition, and support the exploration of intranasal oxytocin as a potential adjunct treatment to improve controlled social cognition in schizophrenia.","content_type":"application/pdf","author_hide":null,"authors":[{"name":"Woolley, JD","email":"josh.woolley@ucsf.edu","fname":"JD","lname":"Woolley","ORCID_id":"0000-0002-4378-0014"},{"name":"Chuang, B","fname":"B","lname":"Chuang"},{"name":"Lam, O","fname":"O","lname":"Lam"},{"name":"Lai, W","fname":"W","lname":"Lai"},{"name":"O'Donovan, A","fname":"A","lname":"O'Donovan"},{"name":"Rankin, KP","email":"kate.rankin@ucsf.edu","fname":"KP","lname":"Rankin"},{"name":"Mathalon, DH","email":"daniel.mathalon@ucsf.edu","fname":"DH","lname":"Mathalon","ORCID_id":"0000-0001-6090-4974"},{"name":"Vinogradov, S","fname":"S","lname":"Vinogradov"}],"supp_files":[{"type":"pdf","count":0},{"type":"image","count":0},{"type":"video","count":0},{"type":"audio","count":0},{"type":"zip","count":0},{"type":"other","count":0}],"thumbnail":{"width":121,"height":167,"asset_id":"871271f27f8a13d36acf1bc1feebfd1b05ee749656dbd7fb7ca85e0f8f252b78","timestamp":1427928119,"image_type":"jpeg"},"pub_year":2014,"genre":"article","rights":"https://creativecommons.org/licenses/by/4.0/","peerReviewed":true,"unitInfo":{"displayName":"UC San Francisco Previously Published Works","link_path":"ucsf_postprints"}}],"facets":[{"display":"Type of Work","fieldName":"type_of_work","facets":[{"value":"article","count":24,"displayName":"Article"},{"value":"monograph","count":0,"displayName":"Book"},{"value":"dissertation","count":0,"displayName":"Theses"},{"value":"multimedia","count":0,"displayName":"Multimedia"}]},{"display":"Peer Review","fieldName":"peer_reviewed","facets":[{"value":"1","count":25,"displayName":"Peer-reviewed only"}]},{"display":"Supplemental Material","fieldName":"supp_file_types","facets":[{"value":"video","count":0,"displayName":"Video"},{"value":"audio","count":0,"displayName":"Audio"},{"value":"images","count":0,"displayName":"Images"},{"value":"zip","count":0,"displayName":"Zip"},{"value":"other files","count":0,"displayName":"Other files"}]},{"display":"Publication Year","fieldName":"pub_year","range":{"pub_year_start":null,"pub_year_end":null}},{"display":"Campus","fieldName":"campuses","facets":[{"value":"ucb","count":0,"displayName":"UC Berkeley"},{"value":"ucd","count":1,"displayName":"UC Davis"},{"value":"uci","count":8,"displayName":"UC Irvine"},{"value":"ucla","count":4,"displayName":"UCLA"},{"value":"ucm","count":0,"displayName":"UC Merced"},{"value":"ucr","count":0,"displayName":"UC Riverside"},{"value":"ucsd","count":5,"displayName":"UC San Diego"},{"value":"ucsf","count":25,"displayName":"UCSF"},{"value":"ucsb","count":0,"displayName":"UC Santa Barbara"},{"value":"ucsc","count":0,"displayName":"UC Santa Cruz"},{"value":"ucop","count":2,"displayName":"UC Office of the President"},{"value":"lbnl","count":0,"displayName":"Lawrence Berkeley National Laboratory"},{"value":"anrcs","count":0,"displayName":"UC Agriculture & Natural Resources"}]},{"display":"Department","fieldName":"departments","facets":[{"value":"ucdavismath","count":1,"displayName":"Department of Mathematics"},{"value":"ucsdpsych","count":2,"displayName":"Department of Psychiatry, UCSD"},{"value":"rgpo","count":2,"displayName":"Research Grants Program Office"},{"value":"ucsdsom","count":4,"displayName":"School of Medicine"},{"value":"uclapsych","count":2,"displayName":"UCLA Department of Psychology"}]},{"display":"Journal","fieldName":"journals","facets":[]},{"display":"Discipline","fieldName":"disciplines","facets":[]},{"display":"Reuse License","fieldName":"rights","facets":[{"value":"CC BY","count":4,"displayName":"BY - Attribution required"},{"value":"CC BY-NC-ND","count":1,"displayName":"BY-NC-ND - Attribution; NonCommercial use; No derivatives"}]}]};</script> <script src="/js/vendors~app-bundle-7424603c338d723fd773.js"></script> <script src="/js/app-bundle-8362e6d7829414ab4baa.js"></script> </body> </html>