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Closed SPIRIT StrokeNet Trials < Neurology
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anchor-copy-button--color-mode--dark"><span class="anchor-copy-button__content"><span class="anchor-copy-button__text">Copy Link</span><svg xmlns="http://www.w3.org/2000/svg" xml:space="preserve" viewBox="0 0 24 24" focusable="false" class="anchor-copy-button__icon"><path d="M5.253 21.497a5.21 5.21 0 0 1-3.712-1.535A5.21 5.21 0 0 1 .006 16.25c0-1.404.545-2.722 1.535-3.712l4.773-4.774a5.22 5.22 0 0 1 3.716-1.539c1.402 0 2.719.544 3.708 1.531a5.225 5.225 0 0 1 .538 6.804.75.75 0 0 1-1.048.165.74.74 0 0 1-.299-.489.75.75 0 0 1 .134-.558 3.73 3.73 0 0 0-.384-4.86 3.73 3.73 0 0 0-2.649-1.094 3.73 3.73 0 0 0-2.655 1.099l-4.774 4.774a3.754 3.754 0 0 0 0 5.303c.707.707 1.649 1.096 2.652 1.096s1.945-.389 2.652-1.096l.932-.932a.744.744 0 0 1 1.06 0 .744.744 0 0 1 0 1.06l-.932.932a5.2 5.2 0 0 1-3.712 1.537"></path><path d="M13.978 18.024a5.21 5.21 0 0 1-3.709-1.535 5.22 5.22 0 0 1-.536-6.803.75.75 0 0 1 1.047-.166.75.75 0 0 1 .3.49.75.75 0 0 1-.134.558 3.73 3.73 0 0 0 .383 4.859 3.73 3.73 0 0 0 2.65 1.096 3.73 3.73 0 0 0 2.654-1.1l4.773-4.773c.708-.708 1.098-1.65 1.098-2.652s-.39-1.943-1.098-2.652c-.707-.707-1.649-1.096-2.652-1.096s-1.945.389-2.652 1.096l-.75.75a.744.744 0 0 1-1.06 0c-.142-.141-.22-.33-.22-.53s.078-.389.22-.53l.75-.75c.99-.99 2.309-1.536 3.712-1.536s2.722.545 3.712 1.536a5.21 5.21 0 0 1 1.538 3.712 5.21 5.21 0 0 1-1.538 3.712l-4.773 4.773a5.21 5.21 0 0 1-3.711 1.54z"></path></svg></span></button></div></div><div class="generic-paragraph__photo-container"><figure class="photo photo--small floating-photo floating-photo--right"><div class="photo__image-container"><span class="" style="display:inline-block"></span></div></figure></div><div class="generic-paragraph__text"><ul> <li>Opened to enrollment since November 2018 </li> <li>Overview: ARCADIA is a multicenter, biomarker-driven, randomized, double-blind, active-control, Phase III clinical trial of apixaban versus aspirin in patients who have evidence of atrial cardiopathy and a recent stroke of unknown cause. Eleven hundred subjects will be recruited at up to 200 sites in the NIH StrokeNET consortium. Subjects will be followed for a minimum of 1.5 years and a maximum of four years for the primary efficacy outcome of recurrent stroke and the primary safety outcomes of symptomatic intracranial hemorrhage and major hemorrhage other than intracranial hemorrhage.</li> </ul> <div> <br> </div> <table class="table-align-left plain"> <tbody> <tr> <th>SPIRIT Site Hub</th> <th>PI at Site</th> </tr> <tr> <td>Hartford Hospital</td> <td>Yan Hou</td> </tr> <tr> <td>St. Vincent's Medical Center</td> <td>Kelly Matmati</td> </tr> <tr> <td>North Shore University Hospital</td> <td>Jeffrey Katz</td> </tr> <tr> <td>Lenox Hill Hospital</td> <td>Salman Azhar</td> </tr> <tr> <td>Rhode Island Hospital</td> <td>Tina Burton</td> </tr> <tr> <td>Yale New Haven Hospital (<a href="https://medicine.yale.edu/ycci/clinicaltrials/trial/arcadia/">Yale IRB HIC# 2000024124</a>) </td> <td>Reshma Narula</td> </tr> </tbody> </table></div></div><div class="generic-paragraph"><div class="heading__container"><h2 class="generic-paragraph__heading" id="arcadia-csi">ARCADIA-CSI</h2><div class="heading__anchor-copy-button-container"><button type="button" aria-label="Copy Link" class="anchor-copy-button anchor-copy-button--color-mode--dark"><span class="anchor-copy-button__content"><span class="anchor-copy-button__text">Copy Link</span><svg xmlns="http://www.w3.org/2000/svg" xml:space="preserve" viewBox="0 0 24 24" focusable="false" class="anchor-copy-button__icon"><path d="M5.253 21.497a5.21 5.21 0 0 1-3.712-1.535A5.21 5.21 0 0 1 .006 16.25c0-1.404.545-2.722 1.535-3.712l4.773-4.774a5.22 5.22 0 0 1 3.716-1.539c1.402 0 2.719.544 3.708 1.531a5.225 5.225 0 0 1 .538 6.804.75.75 0 0 1-1.048.165.74.74 0 0 1-.299-.489.75.75 0 0 1 .134-.558 3.73 3.73 0 0 0-.384-4.86 3.73 3.73 0 0 0-2.649-1.094 3.73 3.73 0 0 0-2.655 1.099l-4.774 4.774a3.754 3.754 0 0 0 0 5.303c.707.707 1.649 1.096 2.652 1.096s1.945-.389 2.652-1.096l.932-.932a.744.744 0 0 1 1.06 0 .744.744 0 0 1 0 1.06l-.932.932a5.2 5.2 0 0 1-3.712 1.537"></path><path d="M13.978 18.024a5.21 5.21 0 0 1-3.709-1.535 5.22 5.22 0 0 1-.536-6.803.75.75 0 0 1 1.047-.166.75.75 0 0 1 .3.49.75.75 0 0 1-.134.558 3.73 3.73 0 0 0 .383 4.859 3.73 3.73 0 0 0 2.65 1.096 3.73 3.73 0 0 0 2.654-1.1l4.773-4.773c.708-.708 1.098-1.65 1.098-2.652s-.39-1.943-1.098-2.652c-.707-.707-1.649-1.096-2.652-1.096s-1.945.389-2.652 1.096l-.75.75a.744.744 0 0 1-1.06 0c-.142-.141-.22-.33-.22-.53s.078-.389.22-.53l.75-.75c.99-.99 2.309-1.536 3.712-1.536s2.722.545 3.712 1.536a5.21 5.21 0 0 1 1.538 3.712 5.21 5.21 0 0 1-1.538 3.712l-4.773 4.773a5.21 5.21 0 0 1-3.711 1.54z"></path></svg></span></button></div></div><div class="generic-paragraph__photo-container"><figure class="photo photo--small floating-photo floating-photo--right"><div class="photo__image-container"><span class="" style="display:inline-block"></span></div></figure></div><div class="generic-paragraph__text"><ul> <li>Open to enrollment: approximately November 2019 <br></li> <li>Overview: Patients randomized in ARCADIA will be eligible for ARCADIA-CSI if they can undergo cognitive testing (English speakers with score <2 on the NIHSS language item) and have no MRI contraindications. Of the 1,100 patients who will be randomized in ARCADIA, we will enroll 500 in ARCADIA-CSI. ARCADIA-CSI subjects will undergo their routine ARCADIA study visits plus: 1) baseline and annual neuropsychological testing; 2) a MRI brain scan at enrollment if not already obtained as part of routine care; and 3) a MRI at their final ARCADIA study visit.</li> </ul> <div> <br> </div> <table class="table-align-left plain"> <tbody> <tr> <th>SPIRIT Site Hub</th> <th>PI at Site</th> </tr> <tr> <td>Hartford Hospital</td> <td>Yan Hou</td> </tr> <tr> <td>North Shore University Hospital</td> <td>Jeffrey Katz</td> </tr> <tr> <td>Rhode Island Hospital</td> <td>Tina Burton</td> </tr> <tr> <td>Yale New Haven Hospital (Yale IRB HIC# 200026199)</td> <td>Reshma Narula</td> </tr> </tbody> </table></div></div><div class="generic-paragraph"><div class="heading__container"><h2 class="generic-paragraph__heading" id="most">MOST</h2><div class="heading__anchor-copy-button-container"><button type="button" aria-label="Copy Link" class="anchor-copy-button anchor-copy-button--color-mode--dark"><span 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2.654-1.1l4.773-4.773c.708-.708 1.098-1.65 1.098-2.652s-.39-1.943-1.098-2.652c-.707-.707-1.649-1.096-2.652-1.096s-1.945.389-2.652 1.096l-.75.75a.744.744 0 0 1-1.06 0c-.142-.141-.22-.33-.22-.53s.078-.389.22-.53l.75-.75c.99-.99 2.309-1.536 3.712-1.536s2.722.545 3.712 1.536a5.21 5.21 0 0 1 1.538 3.712 5.21 5.21 0 0 1-1.538 3.712l-4.773 4.773a5.21 5.21 0 0 1-3.711 1.54z"></path></svg></span></button></div></div><div class="generic-paragraph__photo-container"><figure class="photo photo--small floating-photo floating-photo--right"><div class="photo__image-container"><span class="" style="display:inline-block"></span></div></figure></div><div class="generic-paragraph__text"><ul> <li>Open to enrollment: approximately November 2019</li> <li>Overview: The primary efficacy objective of the MOST trial is to determine if argatroban (100碌g/kg bolus followed by 3碌g/kg per minute for 12 hours) or eptifibatide (135碌g/kg bolus followed by 0.75碌g/kg/min infusion for two hours) results in improved 90-day modified Rankin scores (mRS) as compared with placebo in acute ischemic stroke (AIS) patients treated with 0.9mg/kg IV rt-PA within three hours of symptom onset.</li> </ul> <div> <br> </div> <table class="table-align-left plain"> <tbody> <tr> <th>SPIRIT Site Hub</th> <th>PI at Site</th> </tr> <tr> <td>North Shore University Hospital</td> <td>Rohan Arora</td> </tr> <tr> <td>Yale New Haven Hospital (<a href="https://medicine.yale.edu/ycci/clinicaltrials/trial/multi-arm-optimization-of-stroke-thrombolysis-most/">Yale IRB HIC# 2000024503</a>)</td> <td>Adam Jasne</td> </tr> </tbody> </table></div></div></div> </section></div></div></main><footer class="footer"><div class="footer__primary-panel-wrapper footer__primary-panel-wrapper--full-height"><div class="footer__content-container"><section class="footer__primary-panel" aria-label="Primary Links"><div class="desktop-footer-primary-panel"><div class="desktop-footer-primary-panel__organization-info-wrapper"><div 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Subjects will be followed for a minimum of 1.5 years and a maximum of four years for the primary efficacy outcome of recurrent stroke and the primary safety outcomes of symptomatic intracranial hemorrhage and major hemorrhage other than intracranial hemorrhage.</li>\r\n</ul>\r\n<div>\r\n <br>\r\n</div>\r\n<table class=\"table-align-left plain\">\r\n <tbody>\r\n <tr>\r\n <th>SPIRIT Site Hub</th>\r\n <th>PI at Site</th>\r\n </tr>\r\n <tr>\r\n <td>Hartford Hospital</td>\r\n <td>Yan Hou</td>\r\n </tr>\r\n <tr>\r\n <td>St. Vincent's Medical Center</td>\r\n <td>Kelly Matmati</td>\r\n </tr>\r\n <tr>\r\n <td>North Shore University Hospital</td>\r\n <td>Jeffrey Katz</td>\r\n </tr>\r\n <tr>\r\n <td>Lenox Hill Hospital</td>\r\n <td>Salman Azhar</td>\r\n </tr>\r\n <tr>\r\n <td>Rhode Island Hospital</td>\r\n <td>Tina Burton</td>\r\n </tr>\r\n <tr>\r\n <td>Yale New Haven Hospital (<a href=\"https://medicine.yale.edu/ycci/clinicaltrials/trial/arcadia/\">Yale IRB HIC# 2000024124</a>) </td>\r\n <td>Reshma Narula</td>\r\n </tr>\r\n </tbody>\r\n</table>","photo":{"title":"","caption":null,"credit":null,"imageId":376512,"url":"https://res.cloudinary.com/ysm/image/upload/yms/prod/2ecb24ff-c6c3-47fe-bd7d-f1863ec85e7c","altText":"Arcadia Logo","width":1299,"height":1256,"imageVariants":[]},"imageLink":null,"photoMode":"small","photoAlignment":"right","textInset":{"heading":"","text":""}},{"heading":"ARCADIA-CSI","text":"<ul>\r\n <li>Open to enrollment: approximately November 2019\r\n<br></li>\r\n <li>Overview: Patients randomized in ARCADIA will be eligible for ARCADIA-CSI if they can undergo cognitive testing (English speakers with score &lt;2 on the NIHSS language item) and have no MRI contraindications. Of the 1,100 patients who will be randomized in ARCADIA, we will enroll 500 in ARCADIA-CSI. ARCADIA-CSI subjects will undergo their routine ARCADIA study visits plus: 1) baseline and annual neuropsychological testing; 2) a MRI brain scan at enrollment if not already obtained as part of routine care; and 3) a MRI at their final ARCADIA study visit.</li>\r\n</ul>\r\n<div>\r\n <br>\r\n</div>\r\n<table class=\"table-align-left plain\">\r\n <tbody>\r\n <tr>\r\n <th>SPIRIT Site Hub</th>\r\n <th>PI at Site</th>\r\n </tr>\r\n <tr>\r\n <td>Hartford Hospital</td>\r\n <td>Yan Hou</td>\r\n </tr>\r\n <tr>\r\n <td>North Shore University Hospital</td>\r\n <td>Jeffrey Katz</td>\r\n </tr>\r\n <tr>\r\n <td>Rhode Island Hospital</td>\r\n <td>Tina Burton</td>\r\n </tr>\r\n <tr>\r\n <td>Yale New Haven Hospital (Yale IRB HIC# 200026199)</td>\r\n <td>Reshma Narula</td>\r\n </tr>\r\n </tbody>\r\n</table>","photo":{"title":"","caption":null,"credit":null,"imageId":376516,"url":"https://res.cloudinary.com/ysm/image/upload/yms/prod/4b091c84-f035-4da5-9b54-4e659db3906a","altText":"Arcadia CSI Logo","width":1911,"height":1698,"imageVariants":[]},"imageLink":null,"photoMode":"small","photoAlignment":"right","textInset":{"heading":"","text":""}},{"heading":"MOST","text":"<ul>\r\n <li>Open to enrollment: approximately November 2019</li>\r\n <li>Overview: The primary efficacy objective of the MOST trial is to determine if argatroban (100µg/kg bolus followed by 3µg/kg per minute for 12 hours) or eptifibatide (135µg/kg bolus followed by 0.75µg/kg/min infusion for two hours) results in improved 90-day modified Rankin scores (mRS) as compared with placebo in acute ischemic stroke (AIS) patients treated with 0.9mg/kg IV rt-PA within three hours of symptom onset.</li>\r\n</ul>\r\n<div>\r\n <br>\r\n</div>\r\n<table class=\"table-align-left plain\">\r\n <tbody>\r\n <tr>\r\n <th>SPIRIT Site Hub</th>\r\n <th>PI at Site</th>\r\n </tr>\r\n <tr>\r\n <td>North Shore University Hospital</td>\r\n <td>Rohan Arora</td>\r\n </tr>\r\n <tr>\r\n <td>Yale New Haven Hospital (<a href=\"https://medicine.yale.edu/ycci/clinicaltrials/trial/multi-arm-optimization-of-stroke-thrombolysis-most/\">Yale IRB HIC# 2000024503</a>)</td>\r\n <td>Adam Jasne</td>\r\n </tr>\r\n </tbody>\r\n</table>","photo":{"title":"","caption":null,"credit":null,"imageId":376513,"url":"https://res.cloudinary.com/ysm/image/upload/yms/prod/9e49d255-705a-4cbd-816c-104a8e655357","altText":"MOST Logo","width":1050,"height":450,"imageVariants":[]},"imageLink":null,"photoMode":"small","photoAlignment":"right","textInset":{"heading":"","text":""}}],"relatedLinks":{"title":"Related Link","items":[],"columnsCount":1},"metaData":{"title":"Closed SPIRIT StrokeNet Trials","description":"Opened to enrollment since November 2018  Overview: ARCADIA is a multicenter, biomarker-driven, randomized, double-blind, active-control, Phase III clinical trial of apixaban versus aspirin in patients who have evidence of atrial cardiopathy and a recent stroke of unknown cause. Eleven hundred subjects will be recruited at up to 200 sites in the NIH StrokeNET consortium. Subjects will be followed for a minimum of 1.5 years and a maximum of four years for the primary efficacy outcome of recurrent stroke and the primary safety outcomes of symptomatic intracranial hemorrhage and major hemorrhage other than intracranial hemorrhage. SPIRIT Site Hub PI at Site Hartford Hospital Yan Hou St. Vincent's Medical Center Kelly Matmati North Shore University Hospital Jeffrey Katz Lenox Hill Hospital Salman Azhar Rhode Island Hospital Tina Burton Yale New Haven Hospital (Yale IRB HIC# 2000024124)  Reshma Narula","imageMetaData":{"alt":"Arcadia Logo","width":1200,"height":630,"url":"https://ysm-res.cloudinary.com/image/upload/c_limit,f_auto,h_630,q_auto,w_1200/v1/yms/prod/2ecb24ff-c6c3-47fe-bd7d-f1863ec85e7c","secureUrl":"https://ysm-res.cloudinary.com/image/upload/c_limit,f_auto,h_630,q_auto,w_1200/v1/yms/prod/2ecb24ff-c6c3-47fe-bd7d-f1863ec85e7c"},"videoMetaData":null,"audioMetaData":null,"author":null,"pageType":null,"publishDate":null,"canonicalUrl":null,"isNoIndex":false}}}],"sidebarComponents":[],"contextNavigation":{"siteTitle":"Neurology","isTopLevelPage":false,"navigationItems":[{"link":{"isCurrentLink":false,"rootOrganizationPrefix":null,"currentLinkUrl":null,"url":"/neurology","text":"Home"},"type":"subLevelIndicator","isActive":false,"isHomeLink":true},{"link":{"isCurrentLink":false,"rootOrganizationPrefix":null,"currentLinkUrl":null,"url":"/neurology/research","text":"Research"},"type":"subLevelIndicator","isActive":false,"isHomeLink":false},{"link":{"isCurrentLink":false,"rootOrganizationPrefix":null,"currentLinkUrl":null,"url":"/neurology/research/strokenet","text":"StrokeNet"},"type":"subLevelIndicator","isActive":false,"isHomeLink":false},{"link":{"isCurrentLink":true,"rootOrganizationPrefix":null,"currentLinkUrl":"/neurology/research/strokenet/trials","url":"/neurology/research/strokenet/trials","text":"Trials"},"type":"subLevelIndicator","isActive":true,"isHomeLink":false},{"link":{"isCurrentLink":true,"rootOrganizationPrefix":null,"currentLinkUrl":"/neurology/research/strokenet/trials/closed","url":"/neurology/research/strokenet/trials/closed","text":"Closed SPIRIT StrokeNet Trials"},"type":"pageLink","isActive":true,"isHomeLink":false}]}}</script> <script>window['applicationSettings'] = {"shouldShowSuppressedImageWarnings":false,"shouldShowBugReportButton":false,"shouldShowDownloadAsWordButton":false,"captchaKey":"a46dfca5-98da-4ec7-83e2-16980be648d0","facebookShareUrl":"https://www.facebook.com/dialog/share?app_id=604142276782606&display=popup&href=","isSearchFeedbackEnabled":true,"isSearchAnalyticsEnabled":true,"siteimproveScriptUrl":"https://siteimproveanalytics.com/js/siteanalyze_373.js","radarKey":"prj_live_pk_e9bc38cc9ac871b02332c0d599d7a893c03ad94d","mediaStatistics":{"baseUrl":"https://media-statistics-prod.ysmdevs.com","apiKey":"249c64e3-d0cc-45ed-97a0-5d3106411485","isEnabled":true}};</script> <noscript id="modern__LOADABLE_REQUIRED_CHUNKS__">[6602,3053]</noscript><noscript id="modern__LOADABLE_REQUIRED_CHUNKS___ext">{"namedChunks":["modules-page-components-ComponentWrapper","features-generic-content-components-GenericContent","modules-footer-components-Footer"]}</noscript> <script async data-chunk="main" src="https://cdn1.medicine.yale.edu/build/main.es2015.e71226adbc7ac9e6afaf.js" type="module" crossorigin="anonymous"></script> <script async data-chunk="features-generic-content-components-GenericContent" src="https://cdn1.medicine.yale.edu/build/6602.es2015.bd46f226efa281df2863.js" type="module" crossorigin="anonymous"></script> <script async data-chunk="modules-footer-components-Footer" src="https://cdn1.medicine.yale.edu/build/3053.es2015.404cba0e717f410cb74c.js" type="module" crossorigin="anonymous"></script> <link rel="stylesheet" href="https://use.typekit.net/eqf4dwf.css" as="style" crossorigin> <!--<![endif]--> <script async type="text/plain" data-cookiecategory="analytics" src="https://siteimproveanalytics.com/js/siteanalyze_373.js"></script> </body> </html>