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</div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Deoxyadenozíntrifosfát</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Prejsť na článok v inom jazyku. Je dostupný v 17 jazykoch" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-17" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">17 jazykov</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D8%A3%D8%AF%D9%8A%D9%86%D9%88%D8%B3%D9%8A%D9%86_%D8%AB%D9%84%D8%A7%D8%AB%D9%8A_%D8%A7%D9%84%D9%81%D8%B3%D9%81%D8%A7%D8%AA_%D9%85%D9%86%D9%82%D9%88%D8%B5_%D8%A7%D9%84%D8%A3%D9%83%D8%B3%D8%AC%D9%8A%D9%86" title="أدينوسين ثلاثي الفسفات منقوص الأكسجين – arabčina" lang="ar" hreflang="ar" data-title="أدينوسين ثلاثي الفسفات منقوص الأكسجين" data-language-autonym="العربية" data-language-local-name="arabčina" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-azb mw-list-item"><a href="https://azb.wikipedia.org/wiki/%D8%AF%D8%A6%D9%88%DA%A9%D8%B3%DB%8C_%D8%A2%D8%AF%D9%86%D9%88%D8%B2%DB%8C%D9%86_%D8%AA%D8%B1%DB%8C_%D9%81%D9%88%D8%B3%D9%81%D8%A7%D8%AA" title="دئوکسی آدنوزین تری فوسفات – South Azerbaijani" lang="azb" hreflang="azb" data-title="دئوکسی آدنوزین تری فوسفات" data-language-autonym="تۆرکجه" data-language-local-name="South Azerbaijani" class="interlanguage-link-target"><span>تۆرکجه</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Trifosfat_de_desoxiadenosina" title="Trifosfat de desoxiadenosina – katalánčina" lang="ca" hreflang="ca" data-title="Trifosfat de desoxiadenosina" data-language-autonym="Català" data-language-local-name="katalánčina" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-cs mw-list-item"><a href="https://cs.wikipedia.org/wiki/Deoxyadenosintrifosf%C3%A1t" title="Deoxyadenosintrifosfát – čeština" lang="cs" hreflang="cs" data-title="Deoxyadenosintrifosfát" data-language-autonym="Čeština" data-language-local-name="čeština" class="interlanguage-link-target"><span>Čeština</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Desoxyadenosintriphosphat" title="Desoxyadenosintriphosphat – nemčina" lang="de" hreflang="de" data-title="Desoxyadenosintriphosphat" data-language-autonym="Deutsch" data-language-local-name="nemčina" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Deoxyadenosine_triphosphate" title="Deoxyadenosine triphosphate – angličtina" lang="en" hreflang="en" data-title="Deoxyadenosine triphosphate" data-language-autonym="English" data-language-local-name="angličtina" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Desoxiadenosina_trifosfato" title="Desoxiadenosina trifosfato – španielčina" lang="es" hreflang="es" data-title="Desoxiadenosina trifosfato" data-language-autonym="Español" data-language-local-name="španielčina" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D8%AF%D8%A6%D9%88%DA%A9%D8%B3%DB%8C_%D8%A2%D8%AF%D9%86%D9%88%D8%B2%DB%8C%D9%86_%D8%AA%D8%B1%DB%8C_%D9%81%D8%B3%D9%81%D8%A7%D8%AA" title="دئوکسی آدنوزین تری فسفات – perzština" lang="fa" hreflang="fa" data-title="دئوکسی آدنوزین تری فسفات" data-language-autonym="فارسی" data-language-local-name="perzština" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/D%C3%A9soxyad%C3%A9nosine_triphosphate" title="Désoxyadénosine triphosphate – francúzština" lang="fr" hreflang="fr" data-title="Désoxyadénosine triphosphate" data-language-autonym="Français" data-language-local-name="francúzština" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/Desoxiadenosina_trifosfato" title="Desoxiadenosina trifosfato – galícijčina" lang="gl" hreflang="gl" data-title="Desoxiadenosina trifosfato" data-language-autonym="Galego" data-language-local-name="galícijčina" class="interlanguage-link-target"><span>Galego</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%83%87%E3%82%AA%E3%82%AD%E3%82%B7%E3%82%A2%E3%83%87%E3%83%8E%E3%82%B7%E3%83%B3%E4%B8%89%E3%83%AA%E3%83%B3%E9%85%B8" title="デオキシアデノシン三リン酸 – japončina" lang="ja" hreflang="ja" data-title="デオキシアデノシン三リン酸" data-language-autonym="日本語" data-language-local-name="japončina" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%EB%94%94%EC%98%A5%EC%8B%9C%EC%95%84%EB%8D%B0%EB%85%B8%EC%8B%A0_%EC%82%BC%EC%9D%B8%EC%82%B0" title="디옥시아데노신 삼인산 – kórejčina" lang="ko" hreflang="ko" data-title="디옥시아데노신 삼인산" data-language-autonym="한국어" data-language-local-name="kórejčina" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Desoxyadenosinetrifosfaat" title="Desoxyadenosinetrifosfaat – holandčina" lang="nl" hreflang="nl" data-title="Desoxyadenosinetrifosfaat" data-language-autonym="Nederlands" data-language-local-name="holandčina" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Dezoksiadenozin-trifosfat" title="Dezoksiadenozin-trifosfat – srbochorvátčina" lang="sh" hreflang="sh" data-title="Dezoksiadenozin-trifosfat" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="srbochorvátčina" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Dezoksiadenozin-trifosfat" title="Dezoksiadenozin-trifosfat – srbčina" lang="sr" hreflang="sr" data-title="Dezoksiadenozin-trifosfat" data-language-autonym="Српски / srpski" data-language-local-name="srbčina" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/Deoksiadenozin_trifosfat" title="Deoksiadenozin trifosfat – turečtina" lang="tr" hreflang="tr" data-title="Deoksiadenozin trifosfat" data-language-autonym="Türkçe" data-language-local-name="turečtina" class="interlanguage-link-target"><span>Türkçe</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E8%84%AB%E6%B0%A7%E8%85%BA%E8%8B%B7%E4%B8%89%E7%A3%B7%E9%85%B8" title="脫氧腺苷三磷酸 – čínština" lang="zh" hreflang="zh" data-title="脫氧腺苷三磷酸" data-language-autonym="中文" data-language-local-name="čínština" class="interlanguage-link-target"><span>中文</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q201090#sitelinks-wikipedia" title="Upraviť medzijazykové odkazy" class="wbc-editpage">Upraviť odkazy</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> 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data-event-name="pinnable-header.vector-appearance.unpin">skryť</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">z Wikipédie, slobodnej encyklopédie</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="sk" dir="ltr"><table class="infobox bordered" cellpadding="2" style="width: 300px; font-size:89%"> <tbody><tr> <td colspan="2" style="background-color: #F8EABA; text-align:center; font-weight:bold; font-size:120%">Deoxyadenozíntrifosfát </td></tr> <tr> <td align="center" colspan="2" style="background:white"><figure class="mw-halign-center" typeof="mw:File"><a href="/wiki/S%C3%BAbor:Desoxyadenosintriphosphat_protoniert.svg" class="mw-file-description" title="Deoxyadenozíntrifosfát"><img alt="Deoxyadenozíntrifosfát" src="//upload.wikimedia.org/wikipedia/commons/thumb/b/b2/Desoxyadenosintriphosphat_protoniert.svg/180px-Desoxyadenosintriphosphat_protoniert.svg.png" decoding="async" width="180" height="89" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/b2/Desoxyadenosintriphosphat_protoniert.svg/270px-Desoxyadenosintriphosphat_protoniert.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/b2/Desoxyadenosintriphosphat_protoniert.svg/360px-Desoxyadenosintriphosphat_protoniert.svg.png 2x" data-file-width="514" data-file-height="253" /></a><figcaption>Deoxyadenozíntrifosfát</figcaption></figure> </td></tr><tr><td align="center" colspan="2" style="background:white"> <figure class="mw-halign-center" typeof="mw:File"><a href="/wiki/S%C3%BAbor:Deoxyadenosine-triphosphate-anion-3D-balls.png" class="mw-file-description" title="Deoxyadenozíntrifosfát"><img alt="Deoxyadenozíntrifosfát" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d7/Deoxyadenosine-triphosphate-anion-3D-balls.png/180px-Deoxyadenosine-triphosphate-anion-3D-balls.png" decoding="async" width="180" height="85" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d7/Deoxyadenosine-triphosphate-anion-3D-balls.png/270px-Deoxyadenosine-triphosphate-anion-3D-balls.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d7/Deoxyadenosine-triphosphate-anion-3D-balls.png/360px-Deoxyadenosine-triphosphate-anion-3D-balls.png 2x" data-file-width="2112" data-file-height="1000" /></a><figcaption>Deoxyadenozíntrifosfát</figcaption></figure> </td></tr> <tr> <td colspan="2" style="background-color: #F8EABA; text-align:center;"><b>Všeobecné vlastnosti</b> </td></tr> <tr> <td style="background: #eeeeee; vertical-align: top;"><a href="/wiki/Sum%C3%A1rny_vzorec" title="Sumárny vzorec">Sumárny vzorec</a> </td> <td>C<sub>10</sub>H<sub>16</sub>N<sub>5</sub>O<sub>12</sub>P<sub>3</sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub> </td></tr> <tr> <td style="background: #eeeeee; vertical-align: top;">Synonymá </td> <td>Kyselina [[(2<i>R</i>,3<i>S</i>,5<i>R</i>)-5-(6-aminopurin-9-yl)-3-hydroxyoxolán-2-yl]metoxy-hydroxyfosforyl]fosfónohydrogénfosforečná </td></tr> <tr> <td colspan="2" style="background-color: #F8EABA; text-align:center;"><b>Fyzikálne vlastnosti</b> </td></tr> <tr> <td style="background: #eeeeee; vertical-align: top;"><a href="/wiki/Mol%C3%A1rna_hmotnos%C5%A5" title="Molárna hmotnosť">Molárna hmotnosť</a> </td> <td>491,181623 g/mol </td></tr> <tr> <td colspan="2" style="background-color: #F8EABA; text-align:center;"><b>Ďalšie informácie</b> </td></tr> <tr> <td style="background: #eeeeee; vertical-align: top;"><a href="/wiki/Registra%C4%8Dn%C3%A9_%C4%8D%C3%ADslo_CAS" title="Registračné číslo CAS">Číslo CAS</a> </td> <td>1927-31-7 </td></tr> <tr> <td colspan="2" style="background-color: #F8EABA; font-size:90%; text-align:center">Pokiaľ je to možné a bežné, používame jednotky sústavy <a href="/wiki/SI" title="SI">SI</a>. <br /> Ak nie je hore uvedené inak, údaje sú za <a href="/wiki/Norm%C3%A1lne_podmienky" title="Normálne podmienky">normálnych podmienok</a>. </td></tr> <tr> <td colspan="2" title="Portál, ktorého súčasťou je táto stránka" style="text-align:center; border-top: 1px solid #aaa;"><div style="border: solid #aaa 1px; background: #f9f9f9; padding: 0ex 1ex; display:inline-table; padding: 0ex 0.05ex; border-style:none; background:transparent;" title="Portál, ktorého súčasťou je táto stránka"> <table style="margin: 0; padding: 0ex"> <tbody><tr> <td style="vertical-align:middle;margin: 0;border:none;"> </td> <td style="text-align:left;border:none;"><span class="noviewer" typeof="mw:File"><a href="/wiki/Port%C3%A1l:Ch%C3%A9mia" title="Chemický portál"><img alt="Chemický portál" src="//upload.wikimedia.org/wikipedia/commons/thumb/2/24/Chemistrylogo.png/18px-Chemistrylogo.png" decoding="async" width="18" height="18" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/24/Chemistrylogo.png/27px-Chemistrylogo.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/24/Chemistrylogo.png/36px-Chemistrylogo.png 2x" data-file-width="40" data-file-height="40" /></a></span> <a href="/wiki/Port%C3%A1l:Ch%C3%A9mia" title="Portál:Chémia">Chemický portál</a> </td></tr></tbody></table></div> </td></tr></tbody></table> <p><b>Deoxyadenozíntrifosfát</b> (<b>dATP</b>) je <a href="/wiki/Nukleotid" title="Nukleotid">nukleotid</a>, ktorý sa v bunkách používa na <a href="/w/index.php?title=Synt%C3%A9za_DNA&action=edit&redlink=1" class="new" title="Syntéza DNA (stránka neexistuje)">syntézu DNA</a> (replikáciu). Je to substrát <a href="/wiki/DNA_polymer%C3%A1za" title="DNA polymeráza">DNA polymerázy</a>.<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> Je to <a href="/wiki/Pur%C3%ADn" title="Purín">purínový</a> <a href="/wiki/Nukleozidtrifosf%C3%A1t" title="Nukleozidtrifosfát">nukleozidtrifosfát</a>, ktorý sa skladá z <a href="/wiki/Monosacharid" title="Monosacharid">monosacharidu</a> <a href="/wiki/Deoxyrib%C3%B3za" title="Deoxyribóza">deoxyribózy</a>, na ktorú je naviazaná <a href="/wiki/Dus%C3%ADkat%C3%A1_b%C3%A1za" class="mw-redirect" title="Dusíkatá báza">dusíkatá báza</a> <a href="/wiki/Aden%C3%ADn" title="Adenín">adenín</a> a tri <a href="/wiki/Fosfore%C4%8Dnan" title="Fosforečnan">fosfátové</a> skupiny. Od vysokoenergetického <a href="/wiki/Adenoz%C3%ADntrifosf%C3%A1t" title="Adenozíntrifosfát">adenozíntrifosfátu</a> (ATP) sa líši tým, že na 2' pozícii deoxyribózy nemá <a href="/wiki/Hydroxyl" class="mw-redirect" title="Hydroxyl">hydroxylovú</a> (-OH) skupinu, namiesto ktorej má len <a href="/wiki/Vod%C3%ADk" title="Vodík">vodíkový</a> atóm (-H). Dve molekuly fosforečnanu môžu byť hydrolyzované, čím vzniká <a href="/wiki/Deoxyadenoz%C3%ADnmonofosf%C3%A1t" title="Deoxyadenozínmonofosfát">deoxyadenozínmonofosfát</a> (dAMP). Táto reakcia prebieha počas syntézy DNA.<sup id="cite_ref-:0_2-0" class="reference"><a href="#cite_note-:0-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> </p><p>Existujú dôkazy, že dATP môže slúžiť na ako molekula na prenos energie, aby sa zachovala životnosť bunky.<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Syntéza"><span id="Synt.C3.A9za"></span>Syntéza</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Deoxyadenoz%C3%ADntrifosf%C3%A1t&veaction=edit&section=1" title="Upraviť sekciu: Syntéza" class="mw-editsection-visualeditor"><span>upraviť</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Deoxyadenoz%C3%ADntrifosf%C3%A1t&action=edit&section=1" title="Editovat zdrojový kód sekce Syntéza"><span>upraviť zdroj</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Syntéza dATP prebieha enzymaticky. <a href="/wiki/Adenoz%C3%ADndifosf%C3%A1t" title="Adenozíndifosfát">Adenozíndifosfát</a> (ADP) sa premieňa na <a href="/wiki/Deoxyadenoz%C3%ADndifosf%C3%A1t" title="Deoxyadenozíndifosfát">deoxyadenozíndifosfát</a> (dATP) pôsobením <a href="/w/index.php?title=Ribonukleoziddifosf%C3%A1tredukt%C3%A1za&action=edit&redlink=1" class="new" title="Ribonukleoziddifosfátreduktáza (stránka neexistuje)">ribonukleoziddifosfátreduktázy</a>.<sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> dADP sa následne <a href="/wiki/Fosforyl%C3%A1cia" title="Fosforylácia">fosforyluje</a> za vzniku dATP. Okrem toho niektoré organizmy vedia syntetizovť dATP priamo z ATP, pričom dochádza k redukcii buď <a href="/wiki/Formi%C3%A1t" class="mw-redirect" title="Formiát">formiátu</a><sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> alebo <a href="/w/index.php?title=Tioredox%C3%ADn&action=edit&redlink=1" class="new" title="Tioredoxín (stránka neexistuje)">tioredoxínu</a>.<sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p><p>dATP vzniká i rozkladom DNA. Na DNA pôsobí <a href="/w/index.php?title=DN%C3%A1za&action=edit&redlink=1" class="new" title="DNáza (stránka neexistuje)">DNáza</a>, <a href="/wiki/Nukle%C3%A1za" title="Nukleáza">nukleáza</a> P1, <a href="/w/index.php?title=Adenyl%C3%A1tkin%C3%A1za&action=edit&redlink=1" class="new" title="Adenylátkináza (stránka neexistuje)">adenylátkináza</a> a <a href="/w/index.php?title=Pyruv%C3%A1tkin%C3%A1za&action=edit&redlink=1" class="new" title="Pyruvátkináza (stránka neexistuje)">pyruvátkináza</a>.<sup id="cite_ref-:2_7-0" class="reference"><a href="#cite_note-:2-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> Tepelnou denaturáciou DNA a pôsobením DNázy vznikajú <a href="/wiki/Oligom%C3%A9r" title="Oligomér">oligoméry</a> tvorené deoxyribonukleotidmi. Roztok týchto oligomérov sa spracuje nukleázou P1, čím vznikajú deoxynukleozidmonofosfáty. Adenylátkináza a pyruvátkináza potom selektívne premieňajú dAMP na dATP. Po purifikácii je možné získať roztok s čistotou až 90-95 % a asi 40 % výťažok.<sup id="cite_ref-:2_7-1" class="reference"><a href="#cite_note-:2-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Účinok_na_zdravie"><span id=".C3.9A.C4.8Dinok_na_zdravie"></span>Účinok na zdravie</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Deoxyadenoz%C3%ADntrifosf%C3%A1t&veaction=edit&section=2" title="Upraviť sekciu: Účinok na zdravie" class="mw-editsection-visualeditor"><span>upraviť</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Deoxyadenoz%C3%ADntrifosf%C3%A1t&action=edit&section=2" title="Editovat zdrojový kód sekce Účinok na zdravie"><span>upraviť zdroj</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="U_ľudí_s_poruchami_imunity"><span id="U_.C4.BEud.C3.AD_s_poruchami_imunity"></span>U ľudí s poruchami imunity</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Deoxyadenoz%C3%ADntrifosf%C3%A1t&veaction=edit&section=3" title="Upraviť sekciu: U ľudí s poruchami imunity" class="mw-editsection-visualeditor"><span>upraviť</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Deoxyadenoz%C3%ADntrifosf%C3%A1t&action=edit&section=3" title="Editovat zdrojový kód sekce U ľudí s poruchami imunity"><span>upraviť zdroj</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Vysoká hladina dATP v tele môže byť <a href="/wiki/Toxicita" title="Toxicita">toxická</a> a spôsobiť narušenie <a href="/wiki/Imunitn%C3%BD_syst%C3%A9m" title="Imunitný systém">imunitného systému</a>, pretože dATP funguje ako <a href="/w/index.php?title=Nekompetit%C3%ADvny_inhib%C3%ADtor&action=edit&redlink=1" class="new" title="Nekompetitívny inhibítor (stránka neexistuje)">nekompetitívny inhibítor</a> enzýmu <a href="/w/index.php?title=Ribonukleotidredukt%C3%A1za&action=edit&redlink=1" class="new" title="Ribonukleotidreduktáza (stránka neexistuje)">ribonukleotidreduktázy</a> počas syntézy DNA. Pacienti s <a href="/w/index.php?title=Deficiencia_adenoz%C3%ADndeamin%C3%A1zy&action=edit&redlink=1" class="new" title="Deficiencia adenozíndeaminázy (stránka neexistuje)">deficienciou (nedostatkom) adenozíndeaminázy</a> (<a href="/w/index.php?title=Adenoz%C3%ADndeamin%C3%A1za&action=edit&redlink=1" class="new" title="Adenozíndeamináza (stránka neexistuje)">ADA</a>) majú často zvýšenú vnútrobunkovú hladinu dATP, pretože za bežných okolností ADA premieňa adenozín na <a href="/wiki/Inoz%C3%ADn" title="Inozín">inozín</a>, čím sa znižuje jeho koncentrácia.<sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:1_9-0" class="reference"><a href="#cite_note-:1-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p><p>Je známe, že nedostatočná aktivita ADA spôsobuje uniektorých ľudí imunodeficienciu.<sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> Výskum ukázal, že dATP môže byť potenciálny toxický metabolit deficiencie adenozíndeaminázy.<sup id="cite_ref-:1_9-1" class="reference"><a href="#cite_note-:1-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> Pacienti v tejto štúdii, ktorý boli imunodeficientní a mali deficienciu ADA mali až 50× vyššiu hladinu dATP v <a href="/wiki/Erytrocyt" class="mw-redirect" title="Erytrocyt">erytrocytoch</a> oproti pacientom bez týchto deficiencií. Toto je abnormálne a ukazuje dôkaz toho, že zvýšená hladina dATP v erytrocytoch je toxickým metabolitom zodpovedným za deficienciu imunitného systému u ľudí s deficienciou ADA.<sup id="cite_ref-:1_9-2" class="reference"><a href="#cite_note-:1-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> Infúzia normálnych erytrocytov bez deficiencie ADA spôsobila u týchto ľudí stratu dATP v erytrocytoch. </p><p>Bolo ukázané, že bunky, ktoré nemajú možnosť transportovať alebo fosforylovať dATP, vykazujú zvýšenú rezistenciu voči toxickým účinkom nadbytku dATP, čo naznačuje, že toxicita dATP je závislá na intnracelulárnej schopnosti fosforylovať dATP.<sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> Niektoré liečebné postupy pre deficienciu ADA sa teda zameriavajú na redukciu fosforylácie dATP pomocou <a href="/w/index.php?title=Inhib%C3%ADcia&action=edit&redlink=1" class="new" title="Inhibícia (stránka neexistuje)">inhibície</a> zodpovednej <a href="/w/index.php?title=Deoxynukleozidkin%C3%A1za&action=edit&redlink=1" class="new" title="Deoxynukleozidkináza (stránka neexistuje)">deoxynukleozidkinázy</a>, napríklad <a href="/w/index.php?title=Adenoz%C3%ADnkin%C3%A1za&action=edit&redlink=1" class="new" title="Adenozínkináza (stránka neexistuje)">adenozínkinázy</a> a <a href="/w/index.php?title=Deoxycytid%C3%ADnkin%C3%A1za&action=edit&redlink=1" class="new" title="Deoxycytidínkináza (stránka neexistuje)">deoxycytidínkinázy</a>.<sup id="cite_ref-12" class="reference"><a href="#cite_note-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Deoxycytid%C3%ADn" title="Deoxycytidín">Deoxycytidín</a> podávaný intravenózne (do žily) bol takisto použitý ako liečba deficiencie ADA, ale klinická štúdia zistila, že deoxycytidín má len obmedzený klinický efekt na imunitu <a href="/wiki/T-bunka" class="mw-redirect" title="T-bunka">T-buniek</a> pacientov s ADA, no napriek tomu môžu niektorí pacienti reagovať významnejšie na deoxycytidínovú terapiu.<sup id="cite_ref-13" class="reference"><a href="#cite_note-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="V_srdcovom_svale">V srdcovom svale</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Deoxyadenoz%C3%ADntrifosf%C3%A1t&veaction=edit&section=4" title="Upraviť sekciu: V srdcovom svale" class="mw-editsection-visualeditor"><span>upraviť</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Deoxyadenoz%C3%ADntrifosf%C3%A1t&action=edit&section=4" title="Editovat zdrojový kód sekce V srdcovom svale"><span>upraviť zdroj</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Bolo ukázané, že v srdcovom <a href="/wiki/Myoz%C3%ADn" title="Myozín">myozíne</a> je možné dATP využiť ako alternatívu k ATP ako substrát dodávajúci energiu, čím sa sprostredkuje sťah svalu. V experimente s psou <a href="/w/index.php?title=Dilata%C4%8Dn%C3%A1_kardiomyopatia&action=edit&redlink=1" class="new" title="Dilatačná kardiomyopatia (stránka neexistuje)">dilatačnou kardiomyopatiou</a> bolo zistené, že zvýšená hladina dATP v srdcovom svale je potenciálne efektívnym prostriedkom liečby DCM.<sup id="cite_ref-14" class="reference"><a href="#cite_note-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-15" class="reference"><a href="#cite_note-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> dATP môže zvýšiť konktraktilitu aj systolický tlak v zlyhávajúcom srdci a takisto môže zlepšiť kontrakcie, ako i obnoviť srdcovú pumpu.<sup id="cite_ref-16" class="reference"><a href="#cite_note-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> Okrem toho bolo zistené, že dATP nie len obnovuje normálnu systolickú funkciu u pacientov s kardiovaskulárnymi poruchami, ale môže zvýšiť i kontrakciu, ako aj frekvenciu sťahov srdcového svalu u pacientov s konečnými štádiami kongestívneho zlyhania srdca bez prekážania alebo poškodenia systolickej realxácie.<sup id="cite_ref-17" class="reference"><a href="#cite_note-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Inhibícia_ribonukleotidreduktáz"><span id="Inhib.C3.ADcia_ribonukleotidredukt.C3.A1z"></span>Inhibícia ribonukleotidreduktáz</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Deoxyadenoz%C3%ADntrifosf%C3%A1t&veaction=edit&section=5" title="Upraviť sekciu: Inhibícia ribonukleotidreduktáz" class="mw-editsection-visualeditor"><span>upraviť</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Deoxyadenoz%C3%ADntrifosf%C3%A1t&action=edit&section=5" title="Editovat zdrojový kód sekce Inhibícia ribonukleotidreduktáz"><span>upraviť zdroj</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Trieda Ia <a href="/w/index.php?title=Ribonukleotidredukt%C3%A1za&action=edit&redlink=1" class="new" title="Ribonukleotidreduktáza (stránka neexistuje)">ribonukleotidreduktáz</a> v <i><a href="/wiki/E._coli" class="mw-redirect" title="E. coli">E. coli</a></i> potvrdzuje, že dATP reguluje aktivity týchto enzýmov viazaním na A miesto nukleotidových väzbových miest.<sup id="cite_ref-:3_18-0" class="reference"><a href="#cite_note-:3-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup>Táto inhibícia v <i>E. coli</i> pôsobením dATP je kvôli väčšiemu priestoru medzi <a href="/wiki/Cyste%C3%ADn" title="Cysteín">cysteínom</a> a <a href="/wiki/Tyroz%C3%ADn" title="Tyrozín">tyrozylovým</a> radikálom nachádzajúcimi sa v C mieste a β2, čo potom vedie k inhibícii tvorby aktívneho miesta, ktoré je zvyčajne nutné pre redukciu.<sup id="cite_ref-:3_18-1" class="reference"><a href="#cite_note-:3-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup> V ľudskej ribonukldeotidreduktáze indukuje dATP α6 štruktúru, ktorá inhibuje aktivitu enzýmu tým, že obmedzí styk β podjednotky s aktívnym miestom α podjednotky.<sup id="cite_ref-19" class="reference"><a href="#cite_note-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Referencie">Referencie</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Deoxyadenoz%C3%ADntrifosf%C3%A1t&veaction=edit&section=6" title="Upraviť sekciu: Referencie" class="mw-editsection-visualeditor"><span>upraviť</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Deoxyadenoz%C3%ADntrifosf%C3%A1t&action=edit&section=6" title="Editovat zdrojový kód sekce Referencie"><span>upraviť zdroj</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="references"><div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink"><a href="#cite_ref-1">↑</a></span> <span class="reference-text"><cite style="font-style:normal"> A study of the mechanism of T4 DNA polymerase with diastereomeric phosphorothioate analogues of deoxyadenosine triphosphate. <i>The Journal of Biological Chemistry</i>, July 1982, s. 7684–8. <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">DOI</a>: <a rel="nofollow" class="external text" href="https://dx.doi.org/10.1016%2FS0021-9258%2818%2934435-1">10.1016/S0021-9258(18)34435-1</a>. <a class="external mw-magiclink-pmid" rel="nofollow" href="//www.ncbi.nlm.nih.gov/pubmed/7045112?dopt=Abstract">PMID 7045112</a>. </cite></span> </li> <li id="cite_note-:0-2"><span class="mw-cite-backlink"><a href="#cite_ref-:0_2-0">↑</a></span> <span class="reference-text"><cite style="font-style:normal">PUBCHEM. <i>2'-Deoxyadenosine 5'-triphosphate</i> [online]. . <a rel="nofollow" class="external text" href="https://pubchem.ncbi.nlm.nih.gov/compound/15993">Dostupné online.</a> (po anglicky)</cite></span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><a href="#cite_ref-3">↑</a></span> <span class="reference-text"><cite style="font-style:normal"> Deoxyadenosine triphosphate acting as an energy-transferring molecule in adenosine deaminase inhibited human erythrocytes. <i>Biochimica et Biophysica Acta (BBA) - Molecular Cell Research</i>, September 1991, s. 257–62. <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">DOI</a>: <a rel="nofollow" class="external text" href="https://dx.doi.org/10.1016%2F0167-4889%2891%2990084-b">10.1016/0167-4889(91)90084-b</a>. <a class="external mw-magiclink-pmid" rel="nofollow" href="//www.ncbi.nlm.nih.gov/pubmed/1911876?dopt=Abstract">PMID 1911876</a>. </cite></span> </li> <li id="cite_note-4"><span class="mw-cite-backlink"><a href="#cite_ref-4">↑</a></span> <span class="reference-text"><cite style="font-style:normal"> <i>ENZYME - 1.17.4.1 Ribonucleoside-diphosphate reductase</i> [online]. enzyme.expasy.org, [cit. 2022-07-28]. <a rel="nofollow" class="external text" href="https://enzyme.expasy.org/EC/1.17.4.1">Dostupné online.</a> </cite></span> </li> <li id="cite_note-5"><span class="mw-cite-backlink"><a href="#cite_ref-5">↑</a></span> <span class="reference-text"><cite style="font-style:normal"> <i>ENZYME - 1.1.98.6 Ribonucleoside-triphosphate reductase (formate)</i> [online]. enzyme.expasy.org, [cit. 2022-07-28]. <a rel="nofollow" class="external text" href="https://enzyme.expasy.org/EC/1.1.98.6">Dostupné online.</a> </cite></span> </li> <li id="cite_note-6"><span class="mw-cite-backlink"><a href="#cite_ref-6">↑</a></span> <span class="reference-text"><cite style="font-style:normal"> <i>ENZYME - 1.17.4.1 Ribonucleoside-diphosphate reductase</i> [online]. enzyme.expasy.org, [cit. 2022-07-28]. <a rel="nofollow" class="external text" href="https://enzyme.expasy.org/EC/1.17.4.1">Dostupné online.</a> </cite></span> </li> <li id="cite_note-:2-7"><span class="mw-cite-backlink">↑ <a href="#cite_ref-:2_7-0"><sup style="font-style: italic; font-weight: bold; vertical-align: top">a</sup></a> <a href="#cite_ref-:2_7-1"><sup style="font-style: italic; font-weight: bold; vertical-align: top">b</sup></a></span> <span class="reference-text"><cite style="font-style:normal"> Enzymic synthesis of deoxyATP using DNA as starting material. <i>The Journal of Organic Chemistry</i>, 1985-04-01, s. 1076–1079. <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">DOI</a>: <a rel="nofollow" class="external text" href="https://dx.doi.org/10.1021%2Fjo00207a032">10.1021/jo00207a032</a>. </cite></span> </li> <li id="cite_note-8"><span class="mw-cite-backlink"><a href="#cite_ref-8">↑</a></span> <span class="reference-text"><cite style="font-style:normal"> Effects of deoxyadenosine triphosphate and 9-beta-D-arabinofuranosyl-adenine 5'-triphosphate on human ribonucleotide reductase from Molt-4F cells and the concept of "self-potentiation". <i>Cancer Research</i>, October 1980, s. 3555–8. <a rel="nofollow" class="external text" href="https://cancerres.aacrjournals.org/content/40/10/3555">Dostupné online</a>. <a class="external mw-magiclink-pmid" rel="nofollow" href="//www.ncbi.nlm.nih.gov/pubmed/6159965?dopt=Abstract">PMID 6159965</a>. </cite></span> </li> <li id="cite_note-:1-9"><span class="mw-cite-backlink">↑ <a href="#cite_ref-:1_9-0"><sup style="font-style: italic; font-weight: bold; vertical-align: top">a</sup></a> <a href="#cite_ref-:1_9-1"><sup style="font-style: italic; font-weight: bold; vertical-align: top">b</sup></a> <a href="#cite_ref-:1_9-2"><sup style="font-style: italic; font-weight: bold; vertical-align: top">c</sup></a></span> <span class="reference-text"><cite style="font-style:normal"> Deoxyadenosine triphosphate as a potentially toxic metabolite in adenosine deaminase deficiency. <i>Proceedings of the National Academy of Sciences of the United States of America</i>, January 1978, s. 472–6. <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">DOI</a>: <a rel="nofollow" class="external text" href="https://dx.doi.org/10.1073%2Fpnas.75.1.472">10.1073/pnas.75.1.472</a>. <a class="external mw-magiclink-pmid" rel="nofollow" href="//www.ncbi.nlm.nih.gov/pubmed/272665?dopt=Abstract">PMID 272665</a>. </cite></span> </li> <li id="cite_note-10"><span class="mw-cite-backlink"><a href="#cite_ref-10">↑</a></span> <span class="reference-text"><cite style="font-style:normal"> Carrier frequency of a nonsense mutation in the adenosine deaminase (ADA) gene implies a high incidence of ADA-deficient severe combined immunodeficiency (SCID) in Somalia and a single, common haplotype indicates common ancestry. <i>Annals of Human Genetics</i>, May 2007, s. 336–47. <a 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href="https://dx.doi.org/10.1016%2F0092-8674%2878%2990122-8">10.1016/0092-8674(78)90122-8</a>. <a class="external mw-magiclink-pmid" rel="nofollow" href="//www.ncbi.nlm.nih.gov/pubmed/208780?dopt=Abstract">PMID 208780</a>. 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Heart and Circulatory Physiology</i>, January 2016, s. H80-91. <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">DOI</a>: <a rel="nofollow" class="external text" href="https://dx.doi.org/10.1152%2Fajpheart.00530.2015">10.1152/ajpheart.00530.2015</a>. <a class="external mw-magiclink-pmid" rel="nofollow" href="//www.ncbi.nlm.nih.gov/pubmed/26497964?dopt=Abstract">PMID 26497964</a>. </cite></span> </li> <li id="cite_note-15"><span class="mw-cite-backlink"><a href="#cite_ref-15">↑</a></span> <span class="reference-text"><cite style="font-style:normal"> Cardiac myosin activation with 2-deoxy-ATP via increased electrostatic interactions with actin. <i>Proceedings of the National Academy of Sciences of the United States of America</i>, June 2019, s. 11502–11507. <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">DOI</a>: <a rel="nofollow" class="external text" href="https://dx.doi.org/10.1073%2Fpnas.1905028116">10.1073/pnas.1905028116</a>. <a class="external mw-magiclink-pmid" rel="nofollow" href="//www.ncbi.nlm.nih.gov/pubmed/31110001?dopt=Abstract">PMID 31110001</a>. </cite></span> </li> <li id="cite_note-16"><span class="mw-cite-backlink"><a href="#cite_ref-16">↑</a></span> <span class="reference-text"><cite style="font-style:normal"> Gene Therapy Rescues Cardiac Dysfunction in Duchenne Muscular Dystrophy Mice by Elevating Cardiomyocyte Deoxy-Adenosine Triphosphate. <i>JACC. Basic to Translational Science</i>, Oct 2019, s. 778–791. <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">DOI</a>: <a rel="nofollow" class="external text" href="https://dx.doi.org/10.1016%2Fj.jacbts.2019.06.006">10.1016/j.jacbts.2019.06.006</a>. <a class="external mw-magiclink-pmid" rel="nofollow" href="//www.ncbi.nlm.nih.gov/pubmed/31998848?dopt=Abstract">PMID 31998848</a>. </cite></span> </li> <li id="cite_note-17"><span class="mw-cite-backlink"><a href="#cite_ref-17">↑</a></span> <span class="reference-text"><cite style="font-style:normal"> 2-Deoxy adenosine triphosphate improves contraction in human end-stage heart failure. <i>Journal of Molecular and Cellular Cardiology</i>, Feb 2015, s. 256–263. <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">DOI</a>: <a rel="nofollow" class="external text" href="https://dx.doi.org/10.1016%2Fj.yjmcc.2014.12.002">10.1016/j.yjmcc.2014.12.002</a>. <a class="external mw-magiclink-pmid" rel="nofollow" href="//www.ncbi.nlm.nih.gov/pubmed/25498214?dopt=Abstract">PMID 25498214</a>. </cite></span> </li> <li id="cite_note-:3-18"><span class="mw-cite-backlink">↑ <a href="#cite_ref-:3_18-0"><sup style="font-style: italic; font-weight: bold; vertical-align: top">a</sup></a> <a href="#cite_ref-:3_18-1"><sup style="font-style: italic; font-weight: bold; vertical-align: top">b</sup></a></span> <span class="reference-text"><cite style="font-style:normal"> Basis of dATP inhibition of RNRs. <i>Journal of Biological Chemistry</i>, 29 Jun 2018, s. 10413–10414. <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">DOI</a>: <a rel="nofollow" class="external text" href="https://dx.doi.org/10.1074%2Fjbc.H118.003717">10.1074/jbc.H118.003717</a>. <a class="external mw-magiclink-pmid" rel="nofollow" href="//www.ncbi.nlm.nih.gov/pubmed/29959279?dopt=Abstract">PMID 29959279</a>. </cite></span> </li> <li id="cite_note-19"><span class="mw-cite-backlink"><a href="#cite_ref-19">↑</a></span> <span class="reference-text"><cite style="font-style:normal"> Allosteric Inhibition of Human Ribonucleotide Reductase by dATP Entails the Stabilization of a Hexamer. <i>American Chemical Society</i>, 21 Dec 2015, s. 373–381. <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">DOI</a>: <a rel="nofollow" class="external text" href="https://dx.doi.org/10.1021%2Facs.biochem.5b01207">10.1021/acs.biochem.5b01207</a>. <a class="external mw-magiclink-pmid" rel="nofollow" href="//www.ncbi.nlm.nih.gov/pubmed/26727048?dopt=Abstract">PMID 26727048</a>. </cite></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="Pozri_aj">Pozri aj</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Deoxyadenoz%C3%ADntrifosf%C3%A1t&veaction=edit&section=7" title="Upraviť sekciu: Pozri aj" class="mw-editsection-visualeditor"><span>upraviť</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Deoxyadenoz%C3%ADntrifosf%C3%A1t&action=edit&section=7" title="Editovat zdrojový kód sekce Pozri aj"><span>upraviť zdroj</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Adenoz%C3%ADntrifosf%C3%A1t" title="Adenozíntrifosfát">Adenozíntrifosfát</a></li> <li><a href="/w/index.php?title=Deficiencia_adenoz%C3%ADndeamin%C3%A1zy&action=edit&redlink=1" class="new" title="Deficiencia adenozíndeaminázy (stránka neexistuje)">Deficiencia adenozíndeaminázy</a></li> <li><a href="/w/index.php?title=Ribonukleotidredukt%C3%A1za&action=edit&redlink=1" class="new" title="Ribonukleotidreduktáza (stránka neexistuje)">Ribonukleotidreduktáza</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="Zdroj">Zdroj</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Deoxyadenoz%C3%ADntrifosf%C3%A1t&veaction=edit&section=8" title="Upraviť sekciu: Zdroj" class="mw-editsection-visualeditor"><span>upraviť</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Deoxyadenoz%C3%ADntrifosf%C3%A1t&action=edit&section=8" title="Editovat zdrojový kód sekce Zdroj"><span>upraviť zdroj</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><span class="plainlinks"><i>Tento článok je čiastočný alebo úplný preklad článku <a class="external text" href="https://en.wikipedia.org/wiki/Deoxyadenosine_triphosphate?oldid=1082173509">Deoxyadenosine triphosphate</a> na anglickej Wikipédii.</i></span> </p>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?useformat=desktop&type=1x1&usesul3=0" alt="" width="1" height="1" style="border: none; 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