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data-dom-id="Pill-react-component-a79c5f5a-d39f-4ba6-8320-20dd8b22d682"></div> <div id="Pill-react-component-a79c5f5a-d39f-4ba6-8320-20dd8b22d682"></div> </a></div></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Micaela Wiseman</h3></div><div class="js-work-strip profile--work_container" data-work-id="79829585"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/79829585/Antidepressant_activity_of_pharmacological_and_genetic_deactivation_of_the_small_conductance_calcium_activated_potassium_channel_subtype_3"><img alt="Research paper thumbnail of Antidepressant activity of pharmacological and genetic deactivation of the small-conductance calcium-activated potassium channel subtype-3" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/79829585/Antidepressant_activity_of_pharmacological_and_genetic_deactivation_of_the_small_conductance_calcium_activated_potassium_channel_subtype_3">Antidepressant activity of pharmacological and genetic deactivation of the small-conductance calcium-activated potassium channel subtype-3</a></div><div class="wp-workCard_item"><span>Psychopharmacology</span><span>, 2022</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Rationale The voltage-insensitive, small-conductance calcium-activated potassium (SK) channel is ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Rationale The voltage-insensitive, small-conductance calcium-activated potassium (SK) channel is a key regulator of neuronal depolarization and is implicated in the pathophysiology of depressive disorders. Objective We ascertained whether the SK channel is impaired in the chronic unpredictable stress (CUS) model and whether it can serve as a molecular target of antidepressant action. Methods We assessed the depressive-like behavioral phenotype of CUS-exposed rats and performed post-mortem SK channel binding and activity-dependent zif268 mRNA analyses on their brains. To begin an assessment of SK channel subtypes involved, we examined the effects of genetic and pharmacological inhibition of the SK3 channel using conditional knockout mice and selective SK3 channel negative allosteric modulators (NAMs). Results We found that [ 125 I]apamin binding to SK channels is increased in the prefrontal cortex and decreased in the hippocampus, an effect that was associated with reciprocal levels ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="79829585"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="79829585"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 79829585; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=79829585]").text(description); $(".js-view-count[data-work-id=79829585]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 79829585; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='79829585']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 79829585, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=79829585]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":79829585,"title":"Antidepressant activity of pharmacological and genetic deactivation of the small-conductance calcium-activated potassium channel subtype-3","translated_title":"","metadata":{"abstract":"Rationale The voltage-insensitive, small-conductance calcium-activated potassium (SK) channel is a key regulator of neuronal depolarization and is implicated in the pathophysiology of depressive disorders. Objective We ascertained whether the SK channel is impaired in the chronic unpredictable stress (CUS) model and whether it can serve as a molecular target of antidepressant action. Methods We assessed the depressive-like behavioral phenotype of CUS-exposed rats and performed post-mortem SK channel binding and activity-dependent zif268 mRNA analyses on their brains. To begin an assessment of SK channel subtypes involved, we examined the effects of genetic and pharmacological inhibition of the SK3 channel using conditional knockout mice and selective SK3 channel negative allosteric modulators (NAMs). 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To begin an assessment of SK channel subtypes involved, we examined the effects of genetic and pharmacological inhibition of the SK3 channel using conditional knockout mice and selective SK3 channel negative allosteric modulators (NAMs). Results We found that [ 125 I]apamin binding to SK channels is increased in the prefrontal cortex and decreased in the hippocampus, an effect that was associated with reciprocal levels ...","internal_url":"https://www.academia.edu/79829585/Antidepressant_activity_of_pharmacological_and_genetic_deactivation_of_the_small_conductance_calcium_activated_potassium_channel_subtype_3","translated_internal_url":"","created_at":"2022-05-24T07:45:38.588-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42491010,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Antidepressant_activity_of_pharmacological_and_genetic_deactivation_of_the_small_conductance_calcium_activated_potassium_channel_subtype_3","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":42491010,"first_name":"Micaela","middle_initials":null,"last_name":"Wiseman","page_name":"MicaelaWiseman","domain_name":"independent","created_at":"2016-02-01T12:33:16.454-08:00","display_name":"Micaela Wiseman","url":"https://independent.academia.edu/MicaelaWiseman"},"attachments":[],"research_interests":[{"id":140,"name":"Pharmacology","url":"https://www.academia.edu/Documents/in/Pharmacology"},{"id":2047,"name":"Psychopharmacology","url":"https://www.academia.edu/Documents/in/Psychopharmacology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":76754,"name":"Antidepressant","url":"https://www.academia.edu/Documents/in/Antidepressant"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="57037919"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/57037919/Older_Adults_With_Cognitive_and_or_Physical_Impairments_Can_Benefit_From_Immersive_Virtual_Reality_Experiences_A_Feasibility_Study"><img alt="Research paper thumbnail of Older Adults With Cognitive and/or Physical Impairments Can Benefit From Immersive Virtual Reality Experiences: A Feasibility Study" class="work-thumbnail" src="https://attachments.academia-assets.com/72129484/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/57037919/Older_Adults_With_Cognitive_and_or_Physical_Impairments_Can_Benefit_From_Immersive_Virtual_Reality_Experiences_A_Feasibility_Study">Older Adults With Cognitive and/or Physical Impairments Can Benefit From Immersive Virtual Reality Experiences: A Feasibility Study</a></div><div class="wp-workCard_item"><span>Frontiers in Medicine</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f67e5cb789f6d3c9196439905ba7ce52" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":72129484,"asset_id":57037919,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/72129484/download_file?st=MTczMjg1ODQ1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="57037919"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="57037919"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 57037919; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=57037919]").text(description); $(".js-view-count[data-work-id=57037919]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 57037919; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='57037919']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 57037919, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "f67e5cb789f6d3c9196439905ba7ce52" } } $('.js-work-strip[data-work-id=57037919]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":57037919,"title":"Older Adults With Cognitive and/or Physical Impairments Can Benefit From Immersive Virtual Reality Experiences: A Feasibility Study","translated_title":"","metadata":{"publisher":"Frontiers Media SA","grobid_abstract":"Background: Older adults living in long term care, rehabilitation hospitals, and seniors' residences often experience reduced mobility, sometimes resulting in confinement indoors and isolation, which can introduce or aggravate symptoms of depression, anxiety, loneliness, and apathy. As Virtual Reality (VR) technologies become increasingly accessible and affordable, there is a unique opportunity to enable older adults to escape their restricted physical realities and be transported to both stimulating and calming places which may improve their general well-being. To date no robust evaluations of the use of immersive VR therapy [experienced through a head-mounted-display (HMD)] for older adults within these settings have been reported. VR-therapy may prove to be a safe, inexpensive, non-pharmacological means of managing depressive symptoms and providing engagement and enjoyment to this rapidly growing demographic. Objectives: Establish whether it is feasible to use immersive VR technology as therapy for older adults who have reduced sensory, mobility and/or impaired cognition. This includes evaluation of tolerability, comfort, and ease of use of the HMD, and of the potential for immersive VR to provide enjoyment/relaxation and reduce anxiety and depressive symptoms. Methods: Sixty-six older adults (mean age 80.5, SD = 10.5) with varying cognitive abilities (normal = 28, mild impairment = 17, moderate impairment = 12, severe impairment = 3, unknown cognitive score = 6), and/or physical impairments, entered a multi-site non-randomized interventional study in Toronto, Canada. Participants experienced 3 to 20 min of 360 •-video footage of nature scenes displayed on Samsung GearVR HMD. Data was collected through pre/post-intervention surveys, standardized observations during intervention, and post-intervention semi-structured interviews addressing the VR experience. Results: All participants completed the study with no negative side-effects reported (e.g., No dizziness, disorientation, interference with hearing aids); the average time spent in VR was 8 min and 76% of participants viewed the entire experience at least Appel et al. VR-therapy for Frail Older Adults once. Participants tolerated the HMD very well; most had positive feedback, feeling more relaxed and adventurous; 76% wanted to try VR again. Better image quality and increased narrative video content were suggested to improve the experience. Conclusion: It is feasible and safe to expose older adults with various levels of cognitive and physical impairments to immersive VR within these settings. Further research should evaluate the potential benefits of VR in different settings (e.g., home/community based) and explore better customization/optimization of the VR content and equipment for the targeted populations.","publication_name":"Frontiers in Medicine","grobid_abstract_attachment_id":72129484},"translated_abstract":null,"internal_url":"https://www.academia.edu/57037919/Older_Adults_With_Cognitive_and_or_Physical_Impairments_Can_Benefit_From_Immersive_Virtual_Reality_Experiences_A_Feasibility_Study","translated_internal_url":"","created_at":"2021-10-10T18:25:51.346-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42491010,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":72129484,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/72129484/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/72129484/download_file?st=MTczMjg1ODQ1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Older_Adults_With_Cognitive_and_or_Physi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/72129484/pdf-libre.pdf?1633917085=\u0026response-content-disposition=attachment%3B+filename%3DOlder_Adults_With_Cognitive_and_or_Physi.pdf\u0026Expires=1732862056\u0026Signature=E-2CjXwBRhbcHe1tmSFltSNaxEV8BTlTpdh6HTTBGfM95ASb8LVeqFtTsQK-WE9G-1o-YX64yYeg8yH20tGYeSu~N1s292Y7T-rtQx8jhidLzQlQlyKsUc63VYB3f-j4I2SigMW1gB~cb8x2Wa0-LbQEjXk-S39FlguM8YX4ynw8ccuGMh2ndwYhmcH5DSnA2D8y5Cro98NYMuhFEiKq5ny7DJEfPvk0l1G-Byt8vK9GF2rlOzidUfcZimee3WxyAyKFcLz0P6XI5RuawVfIYkW-rWv-yyzP7vv6upI~kbOhHke81-umuJVypqGV27iHiHpCgH9rXUKB5CjQE7GdIQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Older_Adults_With_Cognitive_and_or_Physical_Impairments_Can_Benefit_From_Immersive_Virtual_Reality_Experiences_A_Feasibility_Study","translated_slug":"","page_count":13,"language":"en","content_type":"Work","owner":{"id":42491010,"first_name":"Micaela","middle_initials":null,"last_name":"Wiseman","page_name":"MicaelaWiseman","domain_name":"independent","created_at":"2016-02-01T12:33:16.454-08:00","display_name":"Micaela Wiseman","url":"https://independent.academia.edu/MicaelaWiseman"},"attachments":[{"id":72129484,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/72129484/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/72129484/download_file?st=MTczMjg1ODQ1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Older_Adults_With_Cognitive_and_or_Physi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/72129484/pdf-libre.pdf?1633917085=\u0026response-content-disposition=attachment%3B+filename%3DOlder_Adults_With_Cognitive_and_or_Physi.pdf\u0026Expires=1732862056\u0026Signature=E-2CjXwBRhbcHe1tmSFltSNaxEV8BTlTpdh6HTTBGfM95ASb8LVeqFtTsQK-WE9G-1o-YX64yYeg8yH20tGYeSu~N1s292Y7T-rtQx8jhidLzQlQlyKsUc63VYB3f-j4I2SigMW1gB~cb8x2Wa0-LbQEjXk-S39FlguM8YX4ynw8ccuGMh2ndwYhmcH5DSnA2D8y5Cro98NYMuhFEiKq5ny7DJEfPvk0l1G-Byt8vK9GF2rlOzidUfcZimee3WxyAyKFcLz0P6XI5RuawVfIYkW-rWv-yyzP7vv6upI~kbOhHke81-umuJVypqGV27iHiHpCgH9rXUKB5CjQE7GdIQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":2151,"name":"Virtual Reality (Computer Graphics)","url":"https://www.academia.edu/Documents/in/Virtual_Reality_Computer_Graphics_"},{"id":3662,"name":"Dementia","url":"https://www.academia.edu/Documents/in/Dementia"},{"id":50642,"name":"Virtual Reality","url":"https://www.academia.edu/Documents/in/Virtual_Reality"}],"urls":[{"id":12736437,"url":"https://www.frontiersin.org/article/10.3389/fmed.2019.00329/full"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="57037910"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/57037910/Older_Adults_With_Cognitive_and_or_Physical_Impairments_Can_Benefit_From_Immersive_Virtual_Reality_Experiences_A_Feasibility_Study"><img alt="Research paper thumbnail of Older Adults With Cognitive and/or Physical Impairments Can Benefit From Immersive Virtual Reality Experiences: A Feasibility Study" class="work-thumbnail" src="https://attachments.academia-assets.com/72129478/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/57037910/Older_Adults_With_Cognitive_and_or_Physical_Impairments_Can_Benefit_From_Immersive_Virtual_Reality_Experiences_A_Feasibility_Study">Older Adults With Cognitive and/or Physical Impairments Can Benefit From Immersive Virtual Reality Experiences: A Feasibility Study</a></div><div class="wp-workCard_item"><span>Frontiers in Medicine</span><span>, Jan 15, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Older adults living in long term care, rehabilitation hospitals, and seniors' residen...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Older adults living in long term care, rehabilitation hospitals, and seniors' residences often experience reduced mobility, sometimes resulting in confinement indoors and isolation, which can introduce or aggravate symptoms of depression, anxiety, loneliness, and apathy. As Virtual Reality (VR) technologies become increasingly accessible and affordable, there is a unique opportunity to enable older adults to escape their restricted physical realities and be transported to both stimulating and calming places which may improve their general well-being. To date no robust evaluations of the use of immersive VR therapy [experienced through a head-mounted-display (HMD)] for older adults within these settings have been reported. VR-therapy may prove to be a safe, inexpensive, non-pharmacological means of managing depressive symptoms and providing engagement and enjoyment to this rapidly growing demographic.Objectives: Establish whether it is feasible to use immersive VR technology as therapy for older adults who have reduced sensory, mobility and/or impaired cognition. This includes evaluation of tolerability, comfort, and ease of use of the HMD, and of the potential for immersive VR to provide enjoyment/relaxation and reduce anxiety and depressive symptoms.Methods: Sixty-six older adults (mean age 80.5, SD = 10.5) with varying cognitive abilities (normal = 28, mild impairment = 17, moderate impairment = 12, severe impairment = 3, unknown cognitive score = 6), and/or physical impairments, entered a multi-site non-randomized interventional study in Toronto, Canada. Participants experienced 3 to 20 min of 360°-video footage of nature scenes displayed on Samsung GearVR HMD. Data was collected through pre/post-intervention surveys, standardized observations during intervention, and post-intervention semi-structured interviews addressing the VR experience.Results: All participants completed the study with no negative side-effects reported (e.g., No dizziness, disorientation, interference with hearing aids); the average time spent in VR was 8 min and 76% of participants viewed the entire experience at least once. Participants tolerated the HMD very well; most had positive feedback, feeling more relaxed and adventurous; 76% wanted to try VR again. Better image quality and increased narrative video content were suggested to improve the experience.Conclusion: It is feasible and safe to expose older adults with various levels of cognitive and physical impairments to immersive VR within these settings. Further research should evaluate the potential benefits of VR in different settings (e.g., home/community based) and explore better customization/optimization of the VR content and equipment for the targeted populations.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="0f1ddb81f70860986e54bdffbe5d1c67" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":72129478,"asset_id":57037910,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/72129478/download_file?st=MTczMjg1ODQ1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="57037910"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="57037910"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 57037910; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=57037910]").text(description); $(".js-view-count[data-work-id=57037910]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 57037910; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='57037910']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 57037910, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "0f1ddb81f70860986e54bdffbe5d1c67" } } $('.js-work-strip[data-work-id=57037910]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":57037910,"title":"Older Adults With Cognitive and/or Physical Impairments Can Benefit From Immersive Virtual Reality Experiences: A Feasibility Study","translated_title":"","metadata":{"abstract":"Background: Older adults living in long term care, rehabilitation hospitals, and seniors' residences often experience reduced mobility, sometimes resulting in confinement indoors and isolation, which can introduce or aggravate symptoms of depression, anxiety, loneliness, and apathy. As Virtual Reality (VR) technologies become increasingly accessible and affordable, there is a unique opportunity to enable older adults to escape their restricted physical realities and be transported to both stimulating and calming places which may improve their general well-being. To date no robust evaluations of the use of immersive VR therapy [experienced through a head-mounted-display (HMD)] for older adults within these settings have been reported. VR-therapy may prove to be a safe, inexpensive, non-pharmacological means of managing depressive symptoms and providing engagement and enjoyment to this rapidly growing demographic.Objectives: Establish whether it is feasible to use immersive VR technology as therapy for older adults who have reduced sensory, mobility and/or impaired cognition. This includes evaluation of tolerability, comfort, and ease of use of the HMD, and of the potential for immersive VR to provide enjoyment/relaxation and reduce anxiety and depressive symptoms.Methods: Sixty-six older adults (mean age 80.5, SD = 10.5) with varying cognitive abilities (normal = 28, mild impairment = 17, moderate impairment = 12, severe impairment = 3, unknown cognitive score = 6), and/or physical impairments, entered a multi-site non-randomized interventional study in Toronto, Canada. Participants experienced 3 to 20 min of 360°-video footage of nature scenes displayed on Samsung GearVR HMD. Data was collected through pre/post-intervention surveys, standardized observations during intervention, and post-intervention semi-structured interviews addressing the VR experience.Results: All participants completed the study with no negative side-effects reported (e.g., No dizziness, disorientation, interference with hearing aids); the average time spent in VR was 8 min and 76% of participants viewed the entire experience at least once. Participants tolerated the HMD very well; most had positive feedback, feeling more relaxed and adventurous; 76% wanted to try VR again. Better image quality and increased narrative video content were suggested to improve the experience.Conclusion: It is feasible and safe to expose older adults with various levels of cognitive and physical impairments to immersive VR within these settings. Further research should evaluate the potential benefits of VR in different settings (e.g., home/community based) and explore better customization/optimization of the VR content and equipment for the targeted populations.","publisher":"Frontiers Media SA","publication_date":{"day":15,"month":1,"year":2020,"errors":{}},"publication_name":"Frontiers in Medicine"},"translated_abstract":"Background: Older adults living in long term care, rehabilitation hospitals, and seniors' residences often experience reduced mobility, sometimes resulting in confinement indoors and isolation, which can introduce or aggravate symptoms of depression, anxiety, loneliness, and apathy. As Virtual Reality (VR) technologies become increasingly accessible and affordable, there is a unique opportunity to enable older adults to escape their restricted physical realities and be transported to both stimulating and calming places which may improve their general well-being. To date no robust evaluations of the use of immersive VR therapy [experienced through a head-mounted-display (HMD)] for older adults within these settings have been reported. VR-therapy may prove to be a safe, inexpensive, non-pharmacological means of managing depressive symptoms and providing engagement and enjoyment to this rapidly growing demographic.Objectives: Establish whether it is feasible to use immersive VR technology as therapy for older adults who have reduced sensory, mobility and/or impaired cognition. This includes evaluation of tolerability, comfort, and ease of use of the HMD, and of the potential for immersive VR to provide enjoyment/relaxation and reduce anxiety and depressive symptoms.Methods: Sixty-six older adults (mean age 80.5, SD = 10.5) with varying cognitive abilities (normal = 28, mild impairment = 17, moderate impairment = 12, severe impairment = 3, unknown cognitive score = 6), and/or physical impairments, entered a multi-site non-randomized interventional study in Toronto, Canada. Participants experienced 3 to 20 min of 360°-video footage of nature scenes displayed on Samsung GearVR HMD. Data was collected through pre/post-intervention surveys, standardized observations during intervention, and post-intervention semi-structured interviews addressing the VR experience.Results: All participants completed the study with no negative side-effects reported (e.g., No dizziness, disorientation, interference with hearing aids); the average time spent in VR was 8 min and 76% of participants viewed the entire experience at least once. Participants tolerated the HMD very well; most had positive feedback, feeling more relaxed and adventurous; 76% wanted to try VR again. Better image quality and increased narrative video content were suggested to improve the experience.Conclusion: It is feasible and safe to expose older adults with various levels of cognitive and physical impairments to immersive VR within these settings. Further research should evaluate the potential benefits of VR in different settings (e.g., home/community based) and explore better customization/optimization of the VR content and equipment for the targeted populations.","internal_url":"https://www.academia.edu/57037910/Older_Adults_With_Cognitive_and_or_Physical_Impairments_Can_Benefit_From_Immersive_Virtual_Reality_Experiences_A_Feasibility_Study","translated_internal_url":"","created_at":"2021-10-10T18:25:43.373-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42491010,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":72129478,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/72129478/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/72129478/download_file?st=MTczMjg1ODQ1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Older_Adults_With_Cognitive_and_or_Physi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/72129478/pdf-libre.pdf?1633917085=\u0026response-content-disposition=attachment%3B+filename%3DOlder_Adults_With_Cognitive_and_or_Physi.pdf\u0026Expires=1732862056\u0026Signature=XeRbZLOGao3KV9cInWX67PVJ1dQaiZ354gPD3wTgBhxSEsJ6oHgS4V2JO2OXYTg-kV-QGimDDz4q9WJglA~ZS4MSzpEU3iqADw2vBP2Uk7uTcG1~b1ss905qy52yP1vbsIWBtR8mR88eM8O6stq1SdI36kck1wjEk8Uon2-JCRSpXDQLsgYCI78jpTllh1o~T8j5w2MDYcxzEvUmxR666Dsmd2epm35TxIIWa7INJ3pUqfvbenCJ0bRizotN3yWGPgD9s4Wl6o6HUqQCyjB~ZUOXCiP0R-CTfCQilYTUaRQekX4ojdZes7b8ArrxDnDDG-iciXsB0-sm~CYD41cEHw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Older_Adults_With_Cognitive_and_or_Physical_Impairments_Can_Benefit_From_Immersive_Virtual_Reality_Experiences_A_Feasibility_Study","translated_slug":"","page_count":13,"language":"en","content_type":"Work","owner":{"id":42491010,"first_name":"Micaela","middle_initials":null,"last_name":"Wiseman","page_name":"MicaelaWiseman","domain_name":"independent","created_at":"2016-02-01T12:33:16.454-08:00","display_name":"Micaela Wiseman","url":"https://independent.academia.edu/MicaelaWiseman"},"attachments":[{"id":72129478,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/72129478/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/72129478/download_file?st=MTczMjg1ODQ1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Older_Adults_With_Cognitive_and_or_Physi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/72129478/pdf-libre.pdf?1633917085=\u0026response-content-disposition=attachment%3B+filename%3DOlder_Adults_With_Cognitive_and_or_Physi.pdf\u0026Expires=1732862056\u0026Signature=XeRbZLOGao3KV9cInWX67PVJ1dQaiZ354gPD3wTgBhxSEsJ6oHgS4V2JO2OXYTg-kV-QGimDDz4q9WJglA~ZS4MSzpEU3iqADw2vBP2Uk7uTcG1~b1ss905qy52yP1vbsIWBtR8mR88eM8O6stq1SdI36kck1wjEk8Uon2-JCRSpXDQLsgYCI78jpTllh1o~T8j5w2MDYcxzEvUmxR666Dsmd2epm35TxIIWa7INJ3pUqfvbenCJ0bRizotN3yWGPgD9s4Wl6o6HUqQCyjB~ZUOXCiP0R-CTfCQilYTUaRQekX4ojdZes7b8ArrxDnDDG-iciXsB0-sm~CYD41cEHw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":2151,"name":"Virtual Reality (Computer Graphics)","url":"https://www.academia.edu/Documents/in/Virtual_Reality_Computer_Graphics_"},{"id":3662,"name":"Dementia","url":"https://www.academia.edu/Documents/in/Dementia"},{"id":50642,"name":"Virtual Reality","url":"https://www.academia.edu/Documents/in/Virtual_Reality"}],"urls":[{"id":12736431,"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974513"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="12428110" id="papers"><div class="js-work-strip profile--work_container" data-work-id="79829585"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/79829585/Antidepressant_activity_of_pharmacological_and_genetic_deactivation_of_the_small_conductance_calcium_activated_potassium_channel_subtype_3"><img alt="Research paper thumbnail of Antidepressant activity of pharmacological and genetic deactivation of the small-conductance calcium-activated potassium channel subtype-3" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/79829585/Antidepressant_activity_of_pharmacological_and_genetic_deactivation_of_the_small_conductance_calcium_activated_potassium_channel_subtype_3">Antidepressant activity of pharmacological and genetic deactivation of the small-conductance calcium-activated potassium channel subtype-3</a></div><div class="wp-workCard_item"><span>Psychopharmacology</span><span>, 2022</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Rationale The voltage-insensitive, small-conductance calcium-activated potassium (SK) channel is ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Rationale The voltage-insensitive, small-conductance calcium-activated potassium (SK) channel is a key regulator of neuronal depolarization and is implicated in the pathophysiology of depressive disorders. Objective We ascertained whether the SK channel is impaired in the chronic unpredictable stress (CUS) model and whether it can serve as a molecular target of antidepressant action. Methods We assessed the depressive-like behavioral phenotype of CUS-exposed rats and performed post-mortem SK channel binding and activity-dependent zif268 mRNA analyses on their brains. To begin an assessment of SK channel subtypes involved, we examined the effects of genetic and pharmacological inhibition of the SK3 channel using conditional knockout mice and selective SK3 channel negative allosteric modulators (NAMs). Results We found that [ 125 I]apamin binding to SK channels is increased in the prefrontal cortex and decreased in the hippocampus, an effect that was associated with reciprocal levels ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="79829585"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="79829585"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 79829585; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=79829585]").text(description); $(".js-view-count[data-work-id=79829585]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 79829585; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='79829585']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 79829585, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=79829585]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":79829585,"title":"Antidepressant activity of pharmacological and genetic deactivation of the small-conductance calcium-activated potassium channel subtype-3","translated_title":"","metadata":{"abstract":"Rationale The voltage-insensitive, small-conductance calcium-activated potassium (SK) channel is a key regulator of neuronal depolarization and is implicated in the pathophysiology of depressive disorders. Objective We ascertained whether the SK channel is impaired in the chronic unpredictable stress (CUS) model and whether it can serve as a molecular target of antidepressant action. Methods We assessed the depressive-like behavioral phenotype of CUS-exposed rats and performed post-mortem SK channel binding and activity-dependent zif268 mRNA analyses on their brains. To begin an assessment of SK channel subtypes involved, we examined the effects of genetic and pharmacological inhibition of the SK3 channel using conditional knockout mice and selective SK3 channel negative allosteric modulators (NAMs). Results We found that [ 125 I]apamin binding to SK channels is increased in the prefrontal cortex and decreased in the hippocampus, an effect that was associated with reciprocal levels ...","publisher":"Psychopharmacology","publication_date":{"day":null,"month":null,"year":2022,"errors":{}},"publication_name":"Psychopharmacology"},"translated_abstract":"Rationale The voltage-insensitive, small-conductance calcium-activated potassium (SK) channel is a key regulator of neuronal depolarization and is implicated in the pathophysiology of depressive disorders. Objective We ascertained whether the SK channel is impaired in the chronic unpredictable stress (CUS) model and whether it can serve as a molecular target of antidepressant action. Methods We assessed the depressive-like behavioral phenotype of CUS-exposed rats and performed post-mortem SK channel binding and activity-dependent zif268 mRNA analyses on their brains. To begin an assessment of SK channel subtypes involved, we examined the effects of genetic and pharmacological inhibition of the SK3 channel using conditional knockout mice and selective SK3 channel negative allosteric modulators (NAMs). Results We found that [ 125 I]apamin binding to SK channels is increased in the prefrontal cortex and decreased in the hippocampus, an effect that was associated with reciprocal levels ...","internal_url":"https://www.academia.edu/79829585/Antidepressant_activity_of_pharmacological_and_genetic_deactivation_of_the_small_conductance_calcium_activated_potassium_channel_subtype_3","translated_internal_url":"","created_at":"2022-05-24T07:45:38.588-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42491010,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Antidepressant_activity_of_pharmacological_and_genetic_deactivation_of_the_small_conductance_calcium_activated_potassium_channel_subtype_3","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":42491010,"first_name":"Micaela","middle_initials":null,"last_name":"Wiseman","page_name":"MicaelaWiseman","domain_name":"independent","created_at":"2016-02-01T12:33:16.454-08:00","display_name":"Micaela Wiseman","url":"https://independent.academia.edu/MicaelaWiseman"},"attachments":[],"research_interests":[{"id":140,"name":"Pharmacology","url":"https://www.academia.edu/Documents/in/Pharmacology"},{"id":2047,"name":"Psychopharmacology","url":"https://www.academia.edu/Documents/in/Psychopharmacology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":76754,"name":"Antidepressant","url":"https://www.academia.edu/Documents/in/Antidepressant"}],"urls":[]}, dispatcherData: dispatcherData }); 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As Virtual Reality (VR) technologies become increasingly accessible and affordable, there is a unique opportunity to enable older adults to escape their restricted physical realities and be transported to both stimulating and calming places which may improve their general well-being. To date no robust evaluations of the use of immersive VR therapy [experienced through a head-mounted-display (HMD)] for older adults within these settings have been reported. VR-therapy may prove to be a safe, inexpensive, non-pharmacological means of managing depressive symptoms and providing engagement and enjoyment to this rapidly growing demographic. Objectives: Establish whether it is feasible to use immersive VR technology as therapy for older adults who have reduced sensory, mobility and/or impaired cognition. This includes evaluation of tolerability, comfort, and ease of use of the HMD, and of the potential for immersive VR to provide enjoyment/relaxation and reduce anxiety and depressive symptoms. Methods: Sixty-six older adults (mean age 80.5, SD = 10.5) with varying cognitive abilities (normal = 28, mild impairment = 17, moderate impairment = 12, severe impairment = 3, unknown cognitive score = 6), and/or physical impairments, entered a multi-site non-randomized interventional study in Toronto, Canada. Participants experienced 3 to 20 min of 360 •-video footage of nature scenes displayed on Samsung GearVR HMD. Data was collected through pre/post-intervention surveys, standardized observations during intervention, and post-intervention semi-structured interviews addressing the VR experience. Results: All participants completed the study with no negative side-effects reported (e.g., No dizziness, disorientation, interference with hearing aids); the average time spent in VR was 8 min and 76% of participants viewed the entire experience at least Appel et al. VR-therapy for Frail Older Adults once. Participants tolerated the HMD very well; most had positive feedback, feeling more relaxed and adventurous; 76% wanted to try VR again. Better image quality and increased narrative video content were suggested to improve the experience. Conclusion: It is feasible and safe to expose older adults with various levels of cognitive and physical impairments to immersive VR within these settings. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="57037910"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/57037910/Older_Adults_With_Cognitive_and_or_Physical_Impairments_Can_Benefit_From_Immersive_Virtual_Reality_Experiences_A_Feasibility_Study"><img alt="Research paper thumbnail of Older Adults With Cognitive and/or Physical Impairments Can Benefit From Immersive Virtual Reality Experiences: A Feasibility Study" class="work-thumbnail" src="https://attachments.academia-assets.com/72129478/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/57037910/Older_Adults_With_Cognitive_and_or_Physical_Impairments_Can_Benefit_From_Immersive_Virtual_Reality_Experiences_A_Feasibility_Study">Older Adults With Cognitive and/or Physical Impairments Can Benefit From Immersive Virtual Reality Experiences: A Feasibility Study</a></div><div class="wp-workCard_item"><span>Frontiers in Medicine</span><span>, Jan 15, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Older adults living in long term care, rehabilitation hospitals, and seniors' residen...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Older adults living in long term care, rehabilitation hospitals, and seniors' residences often experience reduced mobility, sometimes resulting in confinement indoors and isolation, which can introduce or aggravate symptoms of depression, anxiety, loneliness, and apathy. As Virtual Reality (VR) technologies become increasingly accessible and affordable, there is a unique opportunity to enable older adults to escape their restricted physical realities and be transported to both stimulating and calming places which may improve their general well-being. To date no robust evaluations of the use of immersive VR therapy [experienced through a head-mounted-display (HMD)] for older adults within these settings have been reported. VR-therapy may prove to be a safe, inexpensive, non-pharmacological means of managing depressive symptoms and providing engagement and enjoyment to this rapidly growing demographic.Objectives: Establish whether it is feasible to use immersive VR technology as therapy for older adults who have reduced sensory, mobility and/or impaired cognition. This includes evaluation of tolerability, comfort, and ease of use of the HMD, and of the potential for immersive VR to provide enjoyment/relaxation and reduce anxiety and depressive symptoms.Methods: Sixty-six older adults (mean age 80.5, SD = 10.5) with varying cognitive abilities (normal = 28, mild impairment = 17, moderate impairment = 12, severe impairment = 3, unknown cognitive score = 6), and/or physical impairments, entered a multi-site non-randomized interventional study in Toronto, Canada. Participants experienced 3 to 20 min of 360°-video footage of nature scenes displayed on Samsung GearVR HMD. Data was collected through pre/post-intervention surveys, standardized observations during intervention, and post-intervention semi-structured interviews addressing the VR experience.Results: All participants completed the study with no negative side-effects reported (e.g., No dizziness, disorientation, interference with hearing aids); the average time spent in VR was 8 min and 76% of participants viewed the entire experience at least once. Participants tolerated the HMD very well; most had positive feedback, feeling more relaxed and adventurous; 76% wanted to try VR again. Better image quality and increased narrative video content were suggested to improve the experience.Conclusion: It is feasible and safe to expose older adults with various levels of cognitive and physical impairments to immersive VR within these settings. Further research should evaluate the potential benefits of VR in different settings (e.g., home/community based) and explore better customization/optimization of the VR content and equipment for the targeted populations.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="0f1ddb81f70860986e54bdffbe5d1c67" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":72129478,"asset_id":57037910,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/72129478/download_file?st=MTczMjg1ODQ1Niw4LjIyMi4yMDguMTQ2&st=MTczMjg1ODQ1Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="57037910"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="57037910"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 57037910; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=57037910]").text(description); $(".js-view-count[data-work-id=57037910]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 57037910; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='57037910']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 57037910, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "0f1ddb81f70860986e54bdffbe5d1c67" } } $('.js-work-strip[data-work-id=57037910]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":57037910,"title":"Older Adults With Cognitive and/or Physical Impairments Can Benefit From Immersive Virtual Reality Experiences: A Feasibility Study","translated_title":"","metadata":{"abstract":"Background: Older adults living in long term care, rehabilitation hospitals, and seniors' residences often experience reduced mobility, sometimes resulting in confinement indoors and isolation, which can introduce or aggravate symptoms of depression, anxiety, loneliness, and apathy. As Virtual Reality (VR) technologies become increasingly accessible and affordable, there is a unique opportunity to enable older adults to escape their restricted physical realities and be transported to both stimulating and calming places which may improve their general well-being. To date no robust evaluations of the use of immersive VR therapy [experienced through a head-mounted-display (HMD)] for older adults within these settings have been reported. VR-therapy may prove to be a safe, inexpensive, non-pharmacological means of managing depressive symptoms and providing engagement and enjoyment to this rapidly growing demographic.Objectives: Establish whether it is feasible to use immersive VR technology as therapy for older adults who have reduced sensory, mobility and/or impaired cognition. This includes evaluation of tolerability, comfort, and ease of use of the HMD, and of the potential for immersive VR to provide enjoyment/relaxation and reduce anxiety and depressive symptoms.Methods: Sixty-six older adults (mean age 80.5, SD = 10.5) with varying cognitive abilities (normal = 28, mild impairment = 17, moderate impairment = 12, severe impairment = 3, unknown cognitive score = 6), and/or physical impairments, entered a multi-site non-randomized interventional study in Toronto, Canada. Participants experienced 3 to 20 min of 360°-video footage of nature scenes displayed on Samsung GearVR HMD. Data was collected through pre/post-intervention surveys, standardized observations during intervention, and post-intervention semi-structured interviews addressing the VR experience.Results: All participants completed the study with no negative side-effects reported (e.g., No dizziness, disorientation, interference with hearing aids); the average time spent in VR was 8 min and 76% of participants viewed the entire experience at least once. Participants tolerated the HMD very well; most had positive feedback, feeling more relaxed and adventurous; 76% wanted to try VR again. Better image quality and increased narrative video content were suggested to improve the experience.Conclusion: It is feasible and safe to expose older adults with various levels of cognitive and physical impairments to immersive VR within these settings. Further research should evaluate the potential benefits of VR in different settings (e.g., home/community based) and explore better customization/optimization of the VR content and equipment for the targeted populations.","publisher":"Frontiers Media SA","publication_date":{"day":15,"month":1,"year":2020,"errors":{}},"publication_name":"Frontiers in Medicine"},"translated_abstract":"Background: Older adults living in long term care, rehabilitation hospitals, and seniors' residences often experience reduced mobility, sometimes resulting in confinement indoors and isolation, which can introduce or aggravate symptoms of depression, anxiety, loneliness, and apathy. As Virtual Reality (VR) technologies become increasingly accessible and affordable, there is a unique opportunity to enable older adults to escape their restricted physical realities and be transported to both stimulating and calming places which may improve their general well-being. To date no robust evaluations of the use of immersive VR therapy [experienced through a head-mounted-display (HMD)] for older adults within these settings have been reported. VR-therapy may prove to be a safe, inexpensive, non-pharmacological means of managing depressive symptoms and providing engagement and enjoyment to this rapidly growing demographic.Objectives: Establish whether it is feasible to use immersive VR technology as therapy for older adults who have reduced sensory, mobility and/or impaired cognition. This includes evaluation of tolerability, comfort, and ease of use of the HMD, and of the potential for immersive VR to provide enjoyment/relaxation and reduce anxiety and depressive symptoms.Methods: Sixty-six older adults (mean age 80.5, SD = 10.5) with varying cognitive abilities (normal = 28, mild impairment = 17, moderate impairment = 12, severe impairment = 3, unknown cognitive score = 6), and/or physical impairments, entered a multi-site non-randomized interventional study in Toronto, Canada. Participants experienced 3 to 20 min of 360°-video footage of nature scenes displayed on Samsung GearVR HMD. 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Further research should evaluate the potential benefits of VR in different settings (e.g., home/community based) and explore better customization/optimization of the VR content and equipment for the targeted populations.","internal_url":"https://www.academia.edu/57037910/Older_Adults_With_Cognitive_and_or_Physical_Impairments_Can_Benefit_From_Immersive_Virtual_Reality_Experiences_A_Feasibility_Study","translated_internal_url":"","created_at":"2021-10-10T18:25:43.373-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42491010,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":72129478,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/72129478/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/72129478/download_file?st=MTczMjg1ODQ1Niw4LjIyMi4yMDguMTQ2&st=MTczMjg1ODQ1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Older_Adults_With_Cognitive_and_or_Physi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/72129478/pdf-libre.pdf?1633917085=\u0026response-content-disposition=attachment%3B+filename%3DOlder_Adults_With_Cognitive_and_or_Physi.pdf\u0026Expires=1732862056\u0026Signature=XeRbZLOGao3KV9cInWX67PVJ1dQaiZ354gPD3wTgBhxSEsJ6oHgS4V2JO2OXYTg-kV-QGimDDz4q9WJglA~ZS4MSzpEU3iqADw2vBP2Uk7uTcG1~b1ss905qy52yP1vbsIWBtR8mR88eM8O6stq1SdI36kck1wjEk8Uon2-JCRSpXDQLsgYCI78jpTllh1o~T8j5w2MDYcxzEvUmxR666Dsmd2epm35TxIIWa7INJ3pUqfvbenCJ0bRizotN3yWGPgD9s4Wl6o6HUqQCyjB~ZUOXCiP0R-CTfCQilYTUaRQekX4ojdZes7b8ArrxDnDDG-iciXsB0-sm~CYD41cEHw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Older_Adults_With_Cognitive_and_or_Physical_Impairments_Can_Benefit_From_Immersive_Virtual_Reality_Experiences_A_Feasibility_Study","translated_slug":"","page_count":13,"language":"en","content_type":"Work","owner":{"id":42491010,"first_name":"Micaela","middle_initials":null,"last_name":"Wiseman","page_name":"MicaelaWiseman","domain_name":"independent","created_at":"2016-02-01T12:33:16.454-08:00","display_name":"Micaela Wiseman","url":"https://independent.academia.edu/MicaelaWiseman"},"attachments":[{"id":72129478,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/72129478/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/72129478/download_file?st=MTczMjg1ODQ1Niw4LjIyMi4yMDguMTQ2&st=MTczMjg1ODQ1Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Older_Adults_With_Cognitive_and_or_Physi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/72129478/pdf-libre.pdf?1633917085=\u0026response-content-disposition=attachment%3B+filename%3DOlder_Adults_With_Cognitive_and_or_Physi.pdf\u0026Expires=1732862056\u0026Signature=XeRbZLOGao3KV9cInWX67PVJ1dQaiZ354gPD3wTgBhxSEsJ6oHgS4V2JO2OXYTg-kV-QGimDDz4q9WJglA~ZS4MSzpEU3iqADw2vBP2Uk7uTcG1~b1ss905qy52yP1vbsIWBtR8mR88eM8O6stq1SdI36kck1wjEk8Uon2-JCRSpXDQLsgYCI78jpTllh1o~T8j5w2MDYcxzEvUmxR666Dsmd2epm35TxIIWa7INJ3pUqfvbenCJ0bRizotN3yWGPgD9s4Wl6o6HUqQCyjB~ZUOXCiP0R-CTfCQilYTUaRQekX4ojdZes7b8ArrxDnDDG-iciXsB0-sm~CYD41cEHw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":2151,"name":"Virtual Reality (Computer Graphics)","url":"https://www.academia.edu/Documents/in/Virtual_Reality_Computer_Graphics_"},{"id":3662,"name":"Dementia","url":"https://www.academia.edu/Documents/in/Dementia"},{"id":50642,"name":"Virtual Reality","url":"https://www.academia.edu/Documents/in/Virtual_Reality"}],"urls":[{"id":12736431,"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974513"}]}, dispatcherData: dispatcherData }); 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