Protein Data Bank Japan (PDBj): maintaining a structural data archive and resource description framework format | Nucleic Acids Research

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class="article-issue-info"> <div class="volume-issue__wrap"> <div class="volume trailing-comma">Volume 40</div> <div class="issue">Issue D1</div> </div> <div class="ii-pub-date"> 1 January 2012 </div> </div> </a> </div> </div> <div class="content-nav"> <div class="widget widget-ArticleJumpLinks widget-instance-OUP_ArticleJumpLinks_Widget"> <h3 class="contents-title" >Article Contents</h3> <ul class="jumplink-list js-jumplink-list"> <li class="section-jump-link head-1" link-destination="55497340"> <div class="section-jump-link__link-wrap"> <a class="js-jumplink scrollTo" href="#55497340">Abstract</a> </div> </li> <li class="section-jump-link head-1" link-destination="55497341"> <div class="section-jump-link__link-wrap"> <a class="js-jumplink scrollTo" href="#55497341">INTRODUCTION</a> </div> </li> <li class="section-jump-link head-1" link-destination="55497345"> <div class="section-jump-link__link-wrap"> <a class="js-jumplink scrollTo" href="#55497345">WEB INTERFACE</a> </div> </li> <li class="section-jump-link head-1" link-destination="55497356"> <div class="section-jump-link__link-wrap"> <a class="js-jumplink scrollTo" href="#55497356">PDB/RDF: PDB DATA ON THE SEMANTIC WEB</a> </div> </li> <li class="section-jump-link head-1" link-destination="55497370"> <div class="section-jump-link__link-wrap"> <a class="js-jumplink scrollTo" href="#55497370">OTHER TOOLS AND RESOURCES</a> </div> </li> <li class="section-jump-link head-1" link-destination="55497377"> <div class="section-jump-link__link-wrap"> <a class="js-jumplink scrollTo" href="#55497377">FUNDING</a> </div> </li> <li class="section-jump-link head-1" link-destination="55497380"> <div class="section-jump-link__link-wrap"> <a class="js-jumplink scrollTo" href="#55497380">ACKNOWLEDGEMENTS</a> </div> </li> <li class="section-jump-link head-1 backReferenceLink" link-destination="55497382"> <div class="section-jump-link__link-wrap"> <a class="js-jumplink scrollTo" href="#55497382">REFERENCES</a> </div> </li> </ul> 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Tel: +81 6 6879 4311; Fax: <div class="fax">+81 6 6879 8636</div>; Email: <a href="mailto:harukin@protein.osaka-u.ac.jp" target="_blank">harukin@protein.osaka-u.ac.jp</a></div> </div> <div class="info-card-search-label"> Search for other works by this author on: </div> <div class="info-card-search info-card-search-internal"> <a href="/nar/search-results?f_Authors=Haruki+Nakamura" rel="nofollow">Oxford Academic</a> </div> <div class="info-card-search info-card-search-pubmed"> <a href="http://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Nakamura H">PubMed</a> </div> <div class="info-card-search info-card-search-google"> <a href="http://scholar.google.com/scholar?q=author:%22Nakamura Haruki%22">Google Scholar</a> </div> </div> </span> </span> </div> </div> </div> </div> <div class="pub-history-wrap clearfix js-history-dropdown-wrap"> <div class="pub-history-row clearfix"> <div class="ww-citation-primary"><em>Nucleic Acids Research</em>, Volume 40, Issue D1, 1 January 2012, Pages D453–D460, <a href='https://doi.org/10.1093/nar/gkr811'>https://doi.org/10.1093/nar/gkr811</a></div> </div> <div class="pub-history-row clearfix"> <div class="ww-citation-date-wrap"> <div class="citation-label">Published:</div> <div class="citation-date">05 October 2011</div> </div> <a href="javascript:;" class="history-label js-history-dropdown-trigger st-article-history at-ArticleHistory"> <span>Article history</span><i class="icon-general-arrow-filled-down arrow-icon"></i> </a> </div> <div class="ww-history js-history-entries-wrap at-history-entries-wrap"> <div class="history-entry at-history-entry"> <div class="wi-state">Received:</div> <div class="wi-date">08 August 2011</div> </div> <div class="history-entry at-history-entry"> <div class="wi-state">Accepted:</div> <div class="wi-date">15 September 2011</div> </div> <div class="history-entry at-history-entry"> <div class="wi-state">Published:</div> <div class="wi-date">05 October 2011</div> </div> </div> </div> </div> </div> <script> $(document).ready(function () { $('.article-top-widget').on('click', '.ati-toggle-trigger', function () { $(this).find('.icon-general-add, .icon-minus').toggleClass('icon-minus icon-general-add'); 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<div class="navbar-search-advanced"><a href="/nar/advanced-search" class="advanced-search js-advanced-search">Advanced Search</a></div> </div> <div class="navbar-search-collapsed"><a href="javascript:;" class="icon-menu_search js_expand-navsearch"><span class="screenreader-text">Search Menu</span></a></div> </div> </div> <input id="routename" name="RouteName" type="hidden" value="nar" /> </div> </div> </div> </div> <div id="ContentTab" class="content active"> <div class="widget widget-ArticleFulltext widget-instance-OUP_Article_FullText_Widget"> <div class="module-widget"> <div class="widget-items" data-widgetname="ArticleFulltext"> <h2 scrollto-destination=55497340 id="55497340" class="abstract-title js-splitscreen-abstract-title" >Abstract</h2> <section class="abstract"><p class="chapter-para">The Protein Data Bank Japan (PDBj, <a class="link link-uri openInAnotherWindow" href="http://pdbj.org" target="_blank">http://pdbj.org</a>) is a member of the worldwide Protein Data Bank (wwPDB) and accepts and processes the deposited data of experimentally determined macromolecular structures. While maintaining the archive in collaboration with other wwPDB partners, PDBj also provides a wide range of services and tools for analyzing structures and functions of proteins, which are summarized in this article. To enhance the interoperability of the PDB data, we have recently developed PDB/RDF, PDB data in the Resource Description Framework (RDF) format, along with its ontology in the Web Ontology Language (OWL) based on the PDB mmCIF Exchange Dictionary. Being in the standard format for the Semantic Web, the PDB/RDF data provide a means to integrate the PDB with other biological information resources.</p></section> <div class="article-metadata-panel clearfix at-ArticleMetadata"></div> <h2 scrollto-destination=55497341 id="55497341" class="section-title js-splitscreen-section-title" >INTRODUCTION</h2> <p class="chapter-para">As a member of the worldwide Protein Data Bank (wwPDB, <a class="link link-uri openInAnotherWindow" href="http://www.wwpdb.org/" target="_blank">http://www.wwpdb.org/</a>) (<span class="xrefLink" id="jumplink-gkr811-B1"></span><a href="javascript:;" reveal-id="gkr811-B1" data-open="gkr811-B1" class="link link-ref link-reveal xref-bibr">1</a>), the Protein Data Bank Japan (PDBj, <a class="link link-uri openInAnotherWindow" href="http://pdbj.org/" target="_blank">http://pdbj.org/</a>) (<span class="xrefLink" id="jumplink-gkr811-B2"></span><a href="javascript:;" reveal-id="gkr811-B2" data-open="gkr811-B2" class="link link-ref link-reveal xref-bibr">2</a>) accepts and processes PDB entries deposited mainly from Asia and Oceania regions and maintains a centralized archive of macromolecular structures, in collaboration with other wwPDB members, RCSB-PDB (<span class="xrefLink" id="jumplink-gkr811-B3"></span><a href="javascript:;" reveal-id="gkr811-B3" data-open="gkr811-B3" class="link link-ref link-reveal xref-bibr">3</a>), BMRB (<span class="xrefLink" id="jumplink-gkr811-B4"></span><a href="javascript:;" reveal-id="gkr811-B4" data-open="gkr811-B4" class="link link-ref link-reveal xref-bibr">4</a>) in the USA and PDBe (<span class="xrefLink" id="jumplink-gkr811-B5"></span><a href="javascript:;" reveal-id="gkr811-B5" data-open="gkr811-B5" class="link link-ref link-reveal xref-bibr">5</a>) in Europe. The PDBj provides its own data viewer, integrated tools and derived databases in order to facilitate structural biology and bioinformatics research from different perspectives than other members of the wwPDB.</p><p class="chapter-para">PDBj has been engaged in validation of the PDB data description by developing a canonical XML description (PDBML), primarily in collaboration with RCSB-PDB (<span class="xrefLink" id="jumplink-gkr811-B6"></span><a href="javascript:;" reveal-id="gkr811-B6" data-open="gkr811-B6" class="link link-ref link-reveal xref-bibr">6</a>). Based on PDBML, PDBj has established its own data interface, PDBj Mine (<a class="link link-uri openInAnotherWindow" href="http://pdbj.org/mine" target="_blank">http://pdbj.org/mine</a>), which enables the user to perform complex queries using SQL, in addition to standard queries (<span class="xrefLink" id="jumplink-gkr811-B7"></span><a href="javascript:;" reveal-id="gkr811-B7" data-open="gkr811-B7" class="link link-ref link-reveal xref-bibr">7</a>). The entire relational database is now available for download with weekly updates. RESTful web services are also available for PDBj Mine.</p><p class="chapter-para">Very recently, in addition to the above, PDBj has begun to provide data in the Resource Description Framework (RDF) format in which most entities are dereferenceable by unique Uniform Resource Identifiers (URI); (See <a class="link link-uri openInAnotherWindow" href="http://pdbj.org/rdf" target="_blank">http://pdbj.org/rdf</a>). Providing a unique URI to each category element of PDB entries in the RDF format implies that the entire PDB data are accessible on the Web, and that the category elements are linked to one another as well as to external resources. A complete ontology of the RDF in Web Ontology Language (OWL) is also provided, which is based on the established PDB mmCIF Exchange Dictionary so that specialists in structural biology or structural bioinformatics can readily understand the data structures. We believe that this service provides a useful means for automatically processing complex structural information. More importantly, this system should make it possible for the structural information in the PDB to be readily integrated with other biological information resources using Semantic Web frameworks. This will facilitate integration with the new Japanese National Bioscience Database Center (NBDC, <a class="link link-uri openInAnotherWindow" href="http://biosciencedbc.jp/?lng=en" target="_blank">http://biosciencedbc.jp/?lng=en</a>) founded in April 2011.</p> <h2 scrollto-destination=55497345 id="55497345" class="section-title js-splitscreen-section-title" >WEB INTERFACE</h2> <h3 scrollto-destination=55497346 id="55497346" class="section-title js-splitscreen-section-title" >PDBj Mine for searching and retrieving PDB data</h3> <p class="chapter-para">The top page of the PDBj website (<a class="link link-uri openInAnotherWindow" href="http://pdbj.org" target="_blank">http://pdbj.org</a>) is provided in English, Japanese, Korean and Chinese (simplified and traditional). Tutorials for data deposition are also provided in these languages.</p><p class="chapter-para">The main query interface is PDBj Mine (<span class="xrefLink" id="jumplink-gkr811-B7"></span><a href="javascript:;" reveal-id="gkr811-B7" data-open="gkr811-B7" class="link link-ref link-reveal xref-bibr">7</a>), which is based on a relational database (RDB) derived from PDBMLplus files. PDBMLplus files are an enhancement of PDBML files (<span class="xrefLink" id="jumplink-gkr811-B6"></span><a href="javascript:;" reveal-id="gkr811-B6" data-open="gkr811-B6" class="link link-ref link-reveal xref-bibr">6</a>) with additional annotations that have been manually curated or automatically extracted from PDB atomic coordinates or other data sources such as UniProt (<span class="xrefLink" id="jumplink-gkr811-B8"></span><a href="javascript:;" reveal-id="gkr811-B8" data-open="gkr811-B8" class="link link-ref link-reveal xref-bibr">8</a>). The search box on the top page can handle general keywords, author names and amino acid sequence fragments as input. A simple search returns a list of PDB entries. Each PDB entry has its summary page from which more detailed pages containing structural, functional and experimental information are linked.</p><p class="chapter-para">More detailed conditional searches can be performed using the PDBj Mine advanced search interface with which the user can specify a pre-defined set of categories such as release/deposition date, citations, chain types, compounds, experimental techniques, etc.</p><p class="chapter-para">PDBj Mine also allows searching the entire database by using the SQL interface. If the user is familiar with the terms of the PDB mmCIF Exchange Dictionary (<a class="link link-uri openInAnotherWindow" href="http://mmcif.pdb.org/dictionaries/" target="_blank">http://mmcif.pdb.org/dictionaries/</a>), most searches can be accomplished by using category views. The details of the database structure and tutorial for SQL queries can be found in our previous publication (<span class="xrefLink" id="jumplink-gkr811-B7"></span><a href="javascript:;" reveal-id="gkr811-B7" data-open="gkr811-B7" class="link link-ref link-reveal xref-bibr">7</a>) as well as in the PDBj Help page (<a class="link link-uri openInAnotherWindow" href="http://pdbj.org/doc/help" target="_blank">http://pdbj.org/doc/help</a>).</p><p class="chapter-para">The entire RDB is made available for download at our FTP site (<a class="link link-uri openInAnotherWindow" href="ftp://ftp.pdbj.org/mine" target="_blank">ftp://ftp.pdbj.org/mine</a>). The database dump file is weekly updated and incremental update files are also available.</p> <h3 scrollto-destination=55497352 id="55497352" class="section-title js-splitscreen-section-title" >RESTful web services</h3> <p class="chapter-para">Two simple RESTful web service interfaces are provided to allow applications to access the search and retrieval services of PDBj Mine through HTTP GET and POST protocols.</p><p class="chapter-para">One service retrieves a specific element of PDBMLplus data for a PDB entry by specifying an XPath expression in the URL (<a class="link link-uri openInAnotherWindow" href="http://http//service.pdbj.org/mine/xpath/" target="_blank">http//service.pdbj.org/mine/xpath/</a>). For example, the HTTP GET protocol to the URL <a class="link link-uri openInAnotherWindow" href="http://service.pdbj.org/mine/xpath/1GOF//PDBx:entity[@id=‘1’]" target="_blank">http://service.pdbj.org/mine/xpath/1GOF//PDBx:entity[@id=‘1’]</a> returns the content of the PDBML for the entity category with the item entity.id = ‘1’ of the PDB entry 1GOF.</p><p class="chapter-para">The other service queries the RDB of PDBj Mine using SQL expressions (<a class="link link-uri openInAnotherWindow" href="http://service.pdbj.org/mine/sql" target="_blank">http://service.pdbj.org/mine/sql</a>). Simply posting an SQL query to this URL returns the results of the query in XML, CSV (comma-separated value) or TSV (tab-separated value) formats. This interface may be a useful means for simple statistical analyses of PDB data.</p> <h2 scrollto-destination=55497356 id="55497356" class="section-title js-splitscreen-section-title" >PDB/RDF: PDB DATA ON THE SEMANTIC WEB</h2> <p class="chapter-para">While various web-based services facilitate large-scale use of PDB data (<span class="xrefLink" id="jumplink-gkr811-B9"></span><a href="javascript:;" reveal-id="gkr811-B9" data-open="gkr811-B9" class="link link-ref link-reveal xref-bibr">9</a>), their specialized application program interfaces and formats make it difficult to integrate their outputs with those from other resources (<span class="xrefLink" id="jumplink-gkr811-B10"></span><a href="javascript:;" reveal-id="gkr811-B10" data-open="gkr811-B10" class="link link-ref link-reveal xref-bibr">10</a>). The Semantic Web is one possible way to overcome this obstacle (<span class="xrefLink" id="jumplink-gkr811-B11"></span><a href="javascript:;" reveal-id="gkr811-B11" data-open="gkr811-B11" class="link link-ref link-reveal xref-bibr">11</a>,<span class="xrefLink" id="jumplink-gkr811-B12"></span><a href="javascript:;" reveal-id="gkr811-B12" data-open="gkr811-B12" class="link link-ref link-reveal xref-bibr">12</a>) using ‘smart data’ rather than smart applications (<span class="xrefLink" id="jumplink-gkr811-B13"></span><a href="javascript:;" reveal-id="gkr811-B13" data-open="gkr811-B13" class="link link-ref link-reveal xref-bibr">13</a>). To make PDB data compatible with the Semantic Web, we have converted PDBML data into the RDF format (<span class="xrefLink" id="jumplink-gkr811-B14"></span><a href="javascript:;" reveal-id="gkr811-B14" data-open="gkr811-B14" class="link link-ref link-reveal xref-bibr">14</a>), and made it available on our website (<a class="link link-uri openInAnotherWindow" href="http://pdbj.org/rdf" target="_blank">http://pdbj.org/rdf</a>). The RDF is a standard format for the Semantic Web (<a class="link link-uri openInAnotherWindow" href="http://www.w3.org/2011/sw/" target="_blank">http://www.w3.org/2011/sw/</a>) and facilitates exchanging and integrating data originating from diverse sources. Along with the RDF-formatted PDB data (PDB/RDF), we have also translated the PDB mmCIF Exchange Dictionary into the (OWL) (<span class="xrefLink" id="jumplink-gkr811-B15"></span><a href="javascript:;" reveal-id="gkr811-B15" data-open="gkr811-B15" class="link link-ref link-reveal xref-bibr">15</a>), which provides the formal semantics of the PDB data elements and enables inference-based queries.</p><p class="chapter-para">It is noted that the Bio2RDF project (<span class="xrefLink" id="jumplink-gkr811-B16"></span><a href="javascript:;" reveal-id="gkr811-B16" data-open="gkr811-B16" class="link link-ref link-reveal xref-bibr">16</a>) has already been providing a subset of PDB data in the RDF format based on the Bio2RDF ontology (<a class="link link-uri openInAnotherWindow" href="http://bio2rdf.org/" target="_blank">http://bio2rdf.org/</a>). While Bio2RDF aims at integrating essential subsets of a wide range of biological information resources including the PDB, PDB/RDF aims to complement the Bio2RDF by providing more detailed and more comprehensive information specific to the PDB. In the following, we describe the details of the PDB/RDF and its OWL ontology.</p> <h3 scrollto-destination=55497359 id="55497359" class="section-title js-splitscreen-section-title" >OWL ontology based on the PDB exchange data dictionary</h3> <p class="chapter-para">The PDB OWL ontology (<a class="link link-uri openInAnotherWindow" href="http://pdbj.org/schema/pdbx-v40.owl" target="_blank">http://pdbj.org/schema/pdbx-v40.owl</a>) is semi-automatically generated from the PDBML Schema (version 4.0) (<span class="xrefLink" id="jumplink-gkr811-B6"></span><a href="javascript:;" reveal-id="gkr811-B6" data-open="gkr811-B6" class="link link-ref link-reveal xref-bibr">6</a>) which in turn is based on the PDB mmCIF Exchange Dictionary (<a class="link link-uri openInAnotherWindow" href="http://mmcif.pdb.org/dictionaries/" target="_blank">http://mmcif.pdb.org/dictionaries/</a>) (<span class="xrefLink" id="jumplink-gkr811-B17"></span><a href="javascript:;" reveal-id="gkr811-B17" data-open="gkr811-B17" class="link link-ref link-reveal xref-bibr">17</a>). The PDBML Schema defines not only categories and category items, but also the relationship between categories via primary keys and foreign keys. Thus, the categories in each PDB entry can be linked to each other. In addition, some category items refer to external resources such as sequence databases, biological taxonomy and citations. The PDB OWL ontology accounts for this linked structure of the PDBML Schema.</p><p class="chapter-para">The basic conversion scheme from the PDBML Schema to the OWL ontology is as follows: Thus, the PDB/RDF ontology is a straightforward translation of the PDB mmCIF Exchange Dictionary from which users familiar with the dictionary can easily infer the meaning of and interrelationship between the PDB/RDF data. In addition, the PDB/RDF ontology defines simple hierarchical structures for classes and properties so that, in principle, related categories or category items can be obtained at once based on the OWL inference mechanism.</p><ol class="order"><li><p class="chapter-para">Each PDBML category corresponds to an OWL class;</p></li><li><p class="chapter-para">The PDBML ‘datablock’ element representing each PDB entry corresponds to the OWL class ‘datablock’;</p></li><li><p class="chapter-para">Each datablock instance is related to category element holders (‘<em>xyz</em>Category’ XML elements in PDBML where ‘<em>xyz</em>’ is a category such as entity, struct, chem_comp, etc.) by OWL properties (‘has_<em>xyz</em>Category’);</p></li><li><p class="chapter-para">Each category element holder is related to category elements (‘<em>xyz</em>’ elements in PDBML) by OWL properties (‘has_<em>xyz</em>’);</p></li><li><p class="chapter-para">When two categories are related by a foreign key in the PDBML Schema [by means of key and keyref elements of the XML Schema (<span class="xrefLink" id="jumplink-gkr811-B18"></span><a href="javascript:;" reveal-id="gkr811-B18" data-open="gkr811-B18" class="link link-ref link-reveal xref-bibr">18</a>)], a corresponding OWL property is defined for cross-references (e.g. ‘reference_to_<em>xyz</em>’ and ‘referenced_by_<em>xyz</em>’);</p></li><li><p class="chapter-para">When a category item refers to an external resource, that item is linked to the resource by a property (e.g. ‘link_to_uniprot’).</p></li><li><p class="chapter-para">Category items are defined as datatype properties. For example, the ‘entity.pdbx_ec’ item of the entity category is translated to the ‘entity.pdbx_ec’ property.</p></li></ol> <h3 scrollto-destination=55497363 id="55497363" class="section-title js-splitscreen-section-title" >RDF data based on PDBML</h3> <p class="chapter-para">The RDF files of PDB data are automatically generated from PDBML files by XSL transformation (<span class="xrefLink" id="jumplink-gkr811-B19"></span><a href="javascript:;" reveal-id="gkr811-B19" data-open="gkr811-B19" class="link link-ref link-reveal xref-bibr">19</a>). However, to reduce the data size, some categories, namely atom_site, entity_poly_seq, pdbx_poly_seq_scheme and pdbx_nonpoly_scheme, are currently excluded. The user who need the full set of RDF data may easily generate them by applying the XSLT stylesheet provided at <a class="link link-uri openInAnotherWindow" href="http://pdbj.org/rdf" target="_blank">http://pdbj.org/rdf</a> to PDBML files. As of August 3, there are in total 565 236 618 RDF triples for 74 888 PDB entries stored in the PDB/RDF.</p><p class="chapter-para">Each category element is assigned a URL that is actually accessible on the Web. For example (<span class="xrefLink" id="jumplink-gkr811-F1"></span><a href="javascript:;" data-modal-source-id="gkr811-F1" class="link xref-fig">Figure 1</a>), the datablock of the PDB entry 1GOF (<span class="xrefLink" id="jumplink-gkr811-B20"></span><a href="javascript:;" reveal-id="gkr811-B20" data-open="gkr811-B20" class="link link-ref link-reveal xref-bibr">20</a>) can be accessed at <a class="link link-uri openInAnotherWindow" href="http://pdbj.org/rdf/1GOF" target="_blank">http://pdbj.org/rdf/1GOF</a>, which contains mainly a list of RDF triples whose subject is the given URL (i.e. <a class="link link-uri openInAnotherWindow" href="http://pdbj.org/rdf/1GOF" target="_blank">http://pdbj.org/rdf/1GOF</a>) and whose objects are mostly the URLs of the category holders. Its category holder for the entity category is found at <a class="link link-uri openInAnotherWindow" href="http://pdbj.org/rdf/1GOF/entityCategory" target="_blank">http://pdbj.org/rdf/1GOF/entityCategory</a>, which in turn contains a list of RDF triples whose subject is the given URL (i.e. <a class="link link-uri openInAnotherWindow" href="http://pdbj.org/rdf/1GOF/entityCategory" target="_blank">http://pdbj.org/rdf/1GOF/entityCategory</a>) and whose objects are mainly its category elements. In general, the URL of a category holder ‘<em>xyz</em>Category’ for a PDB entry is provided as <a class="link link-uri openInAnotherWindow" href="http://pdbj.org/rdf/PDBID/xyzCategory" target="_blank">http://pdbj.org/rdf/PDBID/xyzCategory</a>. A particular entity category element with entity.id = 1 is found at <a class="link link-uri openInAnotherWindow" href="http://pdbj.org/rdf/1GOF/entity/1" target="_blank">http://pdbj.org/rdf/1GOF/entity/1</a>, which lists the content of category items as well as links, if available, to external resources and other category elements in the same entry. Note that the item entity.id is the primary key for the entity category. In general, the URL of a category element ‘<em>xyz</em>’ is provided as <a class="link link-uri openInAnotherWindow" href="http://pdbj.org/rdf/PDBID/xyz/pkey1,pkey2" target="_blank">http://pdbj.org/rdf/PDBID/xyz/pkey1,pkey2</a>, … where <em>pkey1</em>, <em>pkey2</em>, … are the values of the category items that comprise the primary key. In each of these pages, an RDF/XML format data of the subject, property, object triples with its subject being the one specified by the URL is returned. As a whole, the PDB/RDF data of each PDB entry comprise a network of Web resources that are accessible with explicit URLs and are also connected to external Web resources (<span class="xrefLink" id="jumplink-gkr811-F2"></span><a href="javascript:;" data-modal-source-id="gkr811-F2" class="link xref-fig">Figure 2</a>). </p> <a id="55497366" scrollto-destination="55497366"></a> <div data-id="gkr811-f1" data-content-id="gkr811-f1" class="fig fig-section js-fig-section" swap-content-for-modal="true"><div class="graphic-wrap"><img class="content-image" src="https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/nar/40/D1/10.1093_nar_gkr811/2/m_gkr811f1.jpeg?Expires=1736286153&Signature=E0JgsaxQtlAWLuosCSz9NYpfsO8jF04~cCHlNfZz8Tw5c13p7bLV-H6BzFwf49FWcp-sz9He8m6waPuFdEV-9w4nYadhxJ6VrH6LnV3LMArQjSpo-RPd7zy5~Rsq8GW-QYSPaw1rZ3wR-9Ms5axiRg4Ku7TZvOjzQI5ysTaIpNYHyePuU35cuCeeS-5d2OGIDpimzqb85Z4aOUGUAzgkYgEzn7SvtPHRMlnWQzVxjZZk4l5eUzeQ5JxCoFHh4VNxjY~45ByP7SkgpIwd4PCpugxDVbeRSiuHwQ~cxQgUq91fOPkax9EYvgRYlj6BUzrKShWNIfX3jUyFQhK--wEbsg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA" alt="Example of PDB/RDF pages. (A) The PDB/RDF page for the PDB entry 1GOF (http://pdbj.org/rdf/1GOF) displays a list of RDF triples whose subject is the URL itself and objects are mostly the links to the category element holders. (B) The PDB/RDF page for the ‘entity’ category element holder (http://pdbj.org/rdf/1GOF/entityCategory) of the same entry displays a list of entity category elements. (C) The PDB/RDF page for the entity category with entity.id = 1 (http://pdbj.org/rdf/1GOF/entity/1) displays the properties (category items) of the element as well as to links to external resources and cross-references within the entry. The source files of these pages are in the RDF/XML format." data-path-from-xml="gkr811f1.jpeg" /><div class="graphic-bottom"><div class="label fig-label" id="label-55497366">Figure 1.</div><div class="caption fig-caption"><p class="chapter-para">Example of PDB/RDF pages. (<strong>A</strong>) The PDB/RDF page for the PDB entry 1GOF (<a class="link link-uri openInAnotherWindow" href="http://pdbj.org/rdf/1GOF" target="_blank">http://pdbj.org/rdf/1GOF</a>) displays a list of RDF triples whose subject is the URL itself and objects are mostly the links to the category element holders. (<strong>B</strong>) The PDB/RDF page for the ‘entity’ category element holder (<a class="link link-uri openInAnotherWindow" href="http://pdbj.org/rdf/1GOF/entityCategory" target="_blank">http://pdbj.org/rdf/1GOF/entityCategory</a>) of the same entry displays a list of entity category elements. (<strong>C</strong>) The PDB/RDF page for the entity category with entity.id = 1 (<a class="link link-uri openInAnotherWindow" href="http://pdbj.org/rdf/1GOF/entity/1" target="_blank">http://pdbj.org/rdf/1GOF/entity/1</a>) displays the properties (category items) of the element as well as to links to external resources and cross-references within the entry. The source files of these pages are in the RDF/XML format.</p></div><div class="ajax-articleAbstract-exclude-regex fig-orig original-slide figure-button-wrap"><a class="fig-view-orig js-view-large at-figureViewLarge openInAnotherWindow" role="button" aria-describedby="label-55497366" href="/view-large/figure/55497366/gkr811f1.jpeg" data-path-from-xml="gkr811f1.jpeg" target="_blank">Open in new tab</a><a class="download-slide" role="button" aria-describedby="label-55497366" data-section="55497366" href="/DownloadFile/DownloadImage.aspx?image=https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/nar/40/D1/10.1093_nar_gkr811/2/gkr811f1.jpeg?Expires=1736286153&Signature=nV-uIkJZvIqz5bBf24Mr33J7oCqdkRFNjhD~oVzp5kdy30GkAn4C-GcxnE5-XrykGv6cHyUvIjpsU2v1dZJECNviqJbTMOG7I~6glOyWe3te6gZxkkOOEFEE4D5fBbJK5jjKWAmNTSC8cV3wO6QOT3F2VpgJg8b44QyzDdIeX88pOZwREe8aYG6IN0qef~e3qr4S6oNprcOwQ8WOYKXnDW5-j7bk9ANNQkMeZ4jxzamP6l1jK2stiDKVzPFQPgKI7wkkFVsdGh9hVdyrlfCqwwARO4h47Z1JW3mfHzi~ME~8US9ckzzix6-sZC8tCAuJdxNVO5LeXGGaPjciuNNOTg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA&sec=55497366&ar=2903417&xsltPath=~/UI/app/XSLT&imagename=&siteId=5127" data-path-from-xml="gkr811f1.jpeg">Download slide</a></div></div></div></div> <a id="55497367" scrollto-destination="55497367"></a> <div data-id="gkr811-f2" data-content-id="gkr811-f2" class="fig fig-section js-fig-section" swap-content-for-modal="true"><div class="graphic-wrap"><img class="content-image" src="https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/nar/40/D1/10.1093_nar_gkr811/2/m_gkr811f2.jpeg?Expires=1736286153&Signature=dVTA-yfbUlG2MMq3xbn3vzZVBLXMe~YF0~RuqEq6SYfVsNUGe3nikzvH0746vrwgV8FBfZAZq19E4L~iM4tGj1p6i3i2Uz~izC4~3qP0-LU0mv~S3zp8WT6yfk13ghMhSYZuPsvb766Qr~bi3F7C7ym11oC4lWEGiSYc47jBuq00IdFRnS0sw-C0zeqDO6FBUltzkqd5EUCjw5vl7JazwYcKleOvF5-NcY3Hn7UlQvzwX7PmIranAPw3k0sBD7e~0nzNQ0Mk8MpuS7J1hxBI~z1k35jU98WC9dpFwfnOI9iVxkLMfITwWEfbD1P9VAHuV62QUpuXFFFuSkGUQLKxUA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA" alt="Example of an RDF graph for PDB entry 1GOF. (A) The network of RDF resources for the PDB entry 1GOF. Nodes in magenta represent dereferenceable RDF resources within the PDB entry, nodes in green represent external resources; edges represent links between nodes. (B) A subgraph of (A) augmented with literal objects (orange rectangles). Nodes are labeled with simplified URL or literal values and edges with predicates defined in the OWL ontology (‘r:’ and ‘o:’ are short-hands for http://pdbj.org/rdf/ and http://pdbj.org/schema/pdbx-v40.owl#, respectively; ‘UP:’ and ‘Enzyme:’ indicate http://purl.uniprot.org/uniprot/ and http:/purl.uniprot.org/enzyme/, respectively). Diagrams were created using Cytoscape (21)." data-path-from-xml="gkr811f2.jpeg" /><div class="graphic-bottom"><div class="label fig-label" id="label-55497367">Figure 2.</div><div class="caption fig-caption"><p class="chapter-para">Example of an RDF graph for PDB entry 1GOF. (<strong>A</strong>) The network of RDF resources for the PDB entry 1GOF. Nodes in magenta represent dereferenceable RDF resources within the PDB entry, nodes in green represent external resources; edges represent links between nodes. (<strong>B</strong>) A subgraph of (A) augmented with literal objects (orange rectangles). Nodes are labeled with simplified URL or literal values and edges with predicates defined in the OWL ontology (‘r:’ and ‘o:’ are short-hands for <a class="link link-uri openInAnotherWindow" href="http://pdbj.org/rdf/" target="_blank">http://pdbj.org/rdf/</a> and <a class="link link-uri openInAnotherWindow" href="http://pdbj.org/schema/pdbx-v40.owl#" target="_blank">http://pdbj.org/schema/pdbx-v40.owl#</a>, respectively; ‘UP:’ and ‘Enzyme:’ indicate <a class="link link-uri openInAnotherWindow" href="http://purl.uniprot.org/uniprot/" target="_blank">http://purl.uniprot.org/uniprot/</a> and <a class="link link-uri openInAnotherWindow" href="http://http:/purl.uniprot.org/enzyme/" target="_blank">http:/purl.uniprot.org/enzyme/</a>, respectively). Diagrams were created using Cytoscape (<span class="xrefLink" id="jumplink-gkr811-B21"></span><a href="javascript:;" reveal-id="gkr811-B21" data-open="gkr811-B21" class="link link-ref link-reveal xref-bibr">21</a>).</p></div><div class="ajax-articleAbstract-exclude-regex fig-orig original-slide figure-button-wrap"><a class="fig-view-orig js-view-large at-figureViewLarge openInAnotherWindow" role="button" aria-describedby="label-55497367" href="/view-large/figure/55497367/gkr811f2.jpeg" data-path-from-xml="gkr811f2.jpeg" target="_blank">Open in new tab</a><a class="download-slide" role="button" aria-describedby="label-55497367" data-section="55497367" href="/DownloadFile/DownloadImage.aspx?image=https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/nar/40/D1/10.1093_nar_gkr811/2/gkr811f2.jpeg?Expires=1736286153&Signature=MstoZgCdOyXlGpMBe4FsVoFhRY3noQSib9DLIXL9YS5ldZxtDj0toBq12F3V9o-v8JgNlr4oDd5UWWrXF7BuK~jm17d7Z5Gis4ztcodWwTyGQsPsn~Ili3XkDwEbqGAmroRGAiRsiM~E0gKozIdH4LIGfIOJLjk8H7IY3ItYghkF4dPCrDQcZwc9Dms5bS~7zG9gbDRv5D1jpSUzY98WjCS8w5w5PfMnOQGKew1EAi5XNhNOM~yHaWTic-P3c3nVFypGh06hqEhghGs0JEOaphc9pTAaEVTpjMw-L7OTFa1NpXwgI8GMQa95t732WQ9F~C3DW72M99tOTsqWxbOFsg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA&sec=55497367&ar=2903417&xsltPath=~/UI/app/XSLT&imagename=&siteId=5127" data-path-from-xml="gkr811f2.jpeg">Download slide</a></div></div></div></div> <h3 scrollto-destination=55497368 id="55497368" class="section-title js-splitscreen-section-title" >Web interface to PDB/RDF</h3> <p class="chapter-para">Although the PDB/RDF data are primarily intended for software agents, they are also useful for human users to explore the relationship between different data elements in PDB entries. Thus, we provide a simple interface for browsing the PDB/RDF data by applying an XSL stylesheet to the machine-readable RDF format. The user can query the PDB/RDF database with PDB ID, OWL properties or keywords, and follow the links to PDB/RDF resources as well as to external HTML or RDF resources (<span class="xrefLink" id="jumplink-gkr811-F1"></span><a href="javascript:;" data-modal-source-id="gkr811-F1" class="link xref-fig">Figure 1</a>).</p> <h2 scrollto-destination=55497370 id="55497370" class="section-title js-splitscreen-section-title" >OTHER TOOLS AND RESOURCES</h2> <p class="chapter-para">In addition to the services described above, PDBj provides a number of analysis tools and derived databases (<span class="xrefLink" id="jumplink-gkr811-T1"></span><a href="javascript:;" reveal-id="gkr811-T1" data-open="gkr811-T1" class="link link-reveal link-table xref-fig">Table 1</a>). These include search services for various aspects of structural similarity (Sequence Navigator, Structure Navigator, GIRAF, eF-seek), function prediction and annotation (SeSAW, SFAS), structure prediction and modeling services (CRNPRED, Spanner), sequence and structure alignment (ASH, MAFFTash), derived databases (EM Navigator, eF-site, ProMode) and educational resources (Protein Globe, eProtS, Japanese translation of the Molecule of the Month). Among them, we describe below two recently developed services, Yorodumi and EM Navigator. </p> <a id="55497372" scrollto-destination="55497372"></a> <div content-id="gkr811-T1" class="table-modal table-full-width-wrap"><div class="table-wrap table-wide standard-table"><div class="table-wrap-title" id="gkr811-T1" data-id="gkr811-T1"><span class="label title-label" id="label-12765">Table 1.</span><div class="
 graphic-wrap table-open-button-wrap
 "><a class="fig-view-orig at-tableViewLarge openInAnotherWindow btn js-view-large" role="button" target="_blank" href="
 /view-large/55497372" aria-describedby="label-12765"> Open in new tab </a></div><div class="caption caption-id-" id="caption-12765"><p class="chapter-para">Analysis tools and derived databases</p></div> </div><div class="table-overflow"><table role="table" aria-labelledby="
 label-12765" aria-describedby="
 caption-12765"><thead><tr><th>Service<span aria-hidden="true" style="display: none;"> . </span></th><th>Description<span aria-hidden="true" style="display: none;"> . </span></th><th>URL<span class="xrefLink" id="jumplink-TF1"></span><a href="javascript:;" reveal-id="TF1" data-open="TF1" class="link link-ref link-reveal xref-fn js-xref-fn"><sup>a</sup></a><span aria-hidden="true" style="display: none;"> . </span></th><th>Reference<span aria-hidden="true" style="display: none;"> . </span></th></tr></thead><tbody><tr><td>PDBj Mine</td><td>Simple, advanced and SQL search for PDB data</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/mine" target="_blank">pdbj.org/mine</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B7"></span><a href="javascript:;" reveal-id="gkr811-B7" data-open="gkr811-B7" class="link link-ref link-reveal xref-bibr">7</a>)</td></tr><tr><td>Sequence Navigator</td><td>BLAST (<span class="xrefLink" id="jumplink-gkr811-B22"></span><a href="javascript:;" reveal-id="gkr811-B22" data-open="gkr811-B22" class="link link-ref link-reveal xref-bibr">22</a>) search against PDB</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/seqnavix" target="_blank">pdbj.org/seqnavix</a></td><td>–</td></tr><tr><td>Structure Navigator</td><td>ASH structure similarity search</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/stnavix" target="_blank">pdbj.org/stnavix</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B23"></span><a href="javascript:;" reveal-id="gkr811-B23" data-open="gkr811-B23" class="link link-ref link-reveal xref-bibr">23</a>)</td></tr><tr><td>SeSAW</td><td>Functional site prediction</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/sesaw" target="_blank">pdbj.org/sesaw</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B24"></span><a href="javascript:;" reveal-id="gkr811-B24" data-open="gkr811-B24" class="link link-ref link-reveal xref-bibr">24</a>)</td></tr><tr><td>GIRAF</td><td>Interaction interface similarity search</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/giraf" target="_blank">pdbj.org/giraf</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B25 gkr811-B27"></span><a href="javascript:;" reveal-id="gkr811-B25 gkr811-B27" data-open="gkr811-B25 gkr811-B27" class="link link-ref link-reveal xref-bibr">25–27</a>)</td></tr><tr><td>EM Navigator</td><td>EM structure browser</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/emnavi" target="_blank">pdbj.org/emnavi</a></td><td>–</td></tr><tr><td>jV</td><td>Molecular graphics viewer</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/jv" target="_blank">pdbj.org/jv</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B28"></span><a href="javascript:;" reveal-id="gkr811-B28" data-open="gkr811-B28" class="link link-ref link-reveal xref-bibr">28</a>)</td></tr><tr><td>Yorodumi</td><td>Integrated PDB/EMDB data browser</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/yorodumi" target="_blank">pdbj.org/yorodumi</a></td><td>–</td></tr><tr><td>Protein Globe</td><td>“Protein universe” browser</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/globe" target="_blank">pdbj.org/globe</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B2"></span><a href="javascript:;" reveal-id="gkr811-B2" data-open="gkr811-B2" class="link link-ref link-reveal xref-bibr">2</a>)</td></tr><tr><td>ASH</td><td>Pairwise structure alignment</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/ash" target="_blank">pdbj.org/ash</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B23"></span><a href="javascript:;" reveal-id="gkr811-B23" data-open="gkr811-B23" class="link link-ref link-reveal xref-bibr">23</a>,<span class="xrefLink" id="jumplink-gkr811-B29"></span><a href="javascript:;" reveal-id="gkr811-B29" data-open="gkr811-B29" class="link link-ref link-reveal xref-bibr">29</a>,<span class="xrefLink" id="jumplink-gkr811-B30"></span><a href="javascript:;" reveal-id="gkr811-B30" data-open="gkr811-B30" class="link link-ref link-reveal xref-bibr">30</a>)</td></tr><tr><td>MAFTTash</td><td>Integrated multiple sequence/structure alignment</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/mafftash" target="_blank">pdbj.org/mafftash</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B31"></span><a href="javascript:;" reveal-id="gkr811-B31" data-open="gkr811-B31" class="link link-ref link-reveal xref-bibr">31</a>)</td></tr><tr><td>CRNPRED</td><td>One-dimensional structure prediction</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/crnpred" target="_blank">pdbj.org/crnpred</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B32"></span><a href="javascript:;" reveal-id="gkr811-B32" data-open="gkr811-B32" class="link link-ref link-reveal xref-bibr">32</a>,<span class="xrefLink" id="jumplink-gkr811-B33"></span><a href="javascript:;" reveal-id="gkr811-B33" data-open="gkr811-B33" class="link link-ref link-reveal xref-bibr">33</a>)</td></tr><tr><td>Spanner</td><td>Homology modeling</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/spanner" target="_blank">pdbj.org/spanner</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B34"></span><a href="javascript:;" reveal-id="gkr811-B34" data-open="gkr811-B34" class="link link-ref link-reveal xref-bibr">34</a>)</td></tr><tr><td>SFAS</td><td>Automated function annotation</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/sfas" target="_blank">pdbj.org/sfas</a></td><td>–</td></tr><tr><td>eF-site</td><td>Electrostatic surface database</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/ef-site" target="_blank">pdbj.org/ef-site</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B28"></span><a href="javascript:;" reveal-id="gkr811-B28" data-open="gkr811-B28" class="link link-ref link-reveal xref-bibr">28</a>,<span class="xrefLink" id="jumplink-gkr811-B35"></span><a href="javascript:;" reveal-id="gkr811-B35" data-open="gkr811-B35" class="link link-ref link-reveal xref-bibr">35</a>)</td></tr><tr><td>eF-seek</td><td>Search against eF-site</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/ef-seek" target="_blank">pdbj.org/ef-seek</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B36"></span><a href="javascript:;" reveal-id="gkr811-B36" data-open="gkr811-B36" class="link link-ref link-reveal xref-bibr">36</a>)</td></tr><tr><td>eF-surf</td><td>Building electrostatic surfaces</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/ef-surf" target="_blank">pdbj.org/ef-surf</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B36"></span><a href="javascript:;" reveal-id="gkr811-B36" data-open="gkr811-B36" class="link link-ref link-reveal xref-bibr">36</a>)</td></tr><tr><td>ProMode</td><td>Database of normal mode analyses of proteins</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/promode" target="_blank">pdbj.org/promode</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B37"></span><a href="javascript:;" reveal-id="gkr811-B37" data-open="gkr811-B37" class="link link-ref link-reveal xref-bibr">37</a>)</td></tr><tr><td>ProMode Elastic</td><td>ProMode with elastic network model</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/promode_elastic" target="_blank">pdbj.org/promode_elastic</a></td><td>–</td></tr><tr><td>ProMode Oligomer</td><td>ProMode for oligomeric proteins</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/promode_oligomer" target="_blank">pdbj.org/promode_oligomer</a></td><td>–</td></tr><tr><td>eProtS</td><td>Educational articles on protein structures</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/eprots" target="_blank">pdbj.org/eprots</a></td><td>–</td></tr><tr><td>Molecule of the Month</td><td>Japanese translation of RCSB PDB MoM</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/mom" target="_blank">pdbj.org/mom</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B3"></span><a href="javascript:;" reveal-id="gkr811-B3" data-open="gkr811-B3" class="link link-ref link-reveal xref-bibr">3</a>)</td></tr></tbody></table></div><div class="table-modal"><table><thead><tr><th>Service<span aria-hidden="true" style="display: none;"> . </span></th><th>Description<span aria-hidden="true" style="display: none;"> . </span></th><th>URL<span class="xrefLink" id="jumplink-TF1"></span><a href="javascript:;" reveal-id="TF1" data-open="TF1" class="link link-ref link-reveal xref-fn js-xref-fn"><sup>a</sup></a><span aria-hidden="true" style="display: none;"> . </span></th><th>Reference<span aria-hidden="true" style="display: none;"> . </span></th></tr></thead><tbody><tr><td>PDBj Mine</td><td>Simple, advanced and SQL search for PDB data</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/mine" target="_blank">pdbj.org/mine</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B7"></span><a href="javascript:;" reveal-id="gkr811-B7" data-open="gkr811-B7" class="link link-ref link-reveal xref-bibr">7</a>)</td></tr><tr><td>Sequence Navigator</td><td>BLAST (<span class="xrefLink" id="jumplink-gkr811-B22"></span><a href="javascript:;" reveal-id="gkr811-B22" data-open="gkr811-B22" class="link link-ref link-reveal xref-bibr">22</a>) search against PDB</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/seqnavix" target="_blank">pdbj.org/seqnavix</a></td><td>–</td></tr><tr><td>Structure Navigator</td><td>ASH structure similarity search</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/stnavix" target="_blank">pdbj.org/stnavix</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B23"></span><a href="javascript:;" reveal-id="gkr811-B23" data-open="gkr811-B23" class="link link-ref link-reveal xref-bibr">23</a>)</td></tr><tr><td>SeSAW</td><td>Functional site prediction</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/sesaw" target="_blank">pdbj.org/sesaw</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B24"></span><a href="javascript:;" reveal-id="gkr811-B24" data-open="gkr811-B24" class="link link-ref link-reveal xref-bibr">24</a>)</td></tr><tr><td>GIRAF</td><td>Interaction interface similarity search</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/giraf" target="_blank">pdbj.org/giraf</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B25 gkr811-B27"></span><a href="javascript:;" reveal-id="gkr811-B25 gkr811-B27" data-open="gkr811-B25 gkr811-B27" class="link link-ref link-reveal xref-bibr">25–27</a>)</td></tr><tr><td>EM Navigator</td><td>EM structure browser</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/emnavi" target="_blank">pdbj.org/emnavi</a></td><td>–</td></tr><tr><td>jV</td><td>Molecular graphics viewer</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/jv" target="_blank">pdbj.org/jv</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B28"></span><a href="javascript:;" reveal-id="gkr811-B28" data-open="gkr811-B28" class="link link-ref link-reveal xref-bibr">28</a>)</td></tr><tr><td>Yorodumi</td><td>Integrated PDB/EMDB data browser</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/yorodumi" target="_blank">pdbj.org/yorodumi</a></td><td>–</td></tr><tr><td>Protein Globe</td><td>“Protein universe” browser</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/globe" target="_blank">pdbj.org/globe</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B2"></span><a href="javascript:;" reveal-id="gkr811-B2" data-open="gkr811-B2" class="link link-ref link-reveal xref-bibr">2</a>)</td></tr><tr><td>ASH</td><td>Pairwise structure alignment</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/ash" target="_blank">pdbj.org/ash</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B23"></span><a href="javascript:;" reveal-id="gkr811-B23" data-open="gkr811-B23" class="link link-ref link-reveal xref-bibr">23</a>,<span class="xrefLink" id="jumplink-gkr811-B29"></span><a href="javascript:;" reveal-id="gkr811-B29" data-open="gkr811-B29" class="link link-ref link-reveal xref-bibr">29</a>,<span class="xrefLink" id="jumplink-gkr811-B30"></span><a href="javascript:;" reveal-id="gkr811-B30" data-open="gkr811-B30" class="link link-ref link-reveal xref-bibr">30</a>)</td></tr><tr><td>MAFTTash</td><td>Integrated multiple sequence/structure alignment</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/mafftash" target="_blank">pdbj.org/mafftash</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B31"></span><a href="javascript:;" reveal-id="gkr811-B31" data-open="gkr811-B31" class="link link-ref link-reveal xref-bibr">31</a>)</td></tr><tr><td>CRNPRED</td><td>One-dimensional structure prediction</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/crnpred" target="_blank">pdbj.org/crnpred</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B32"></span><a href="javascript:;" reveal-id="gkr811-B32" data-open="gkr811-B32" class="link link-ref link-reveal xref-bibr">32</a>,<span class="xrefLink" id="jumplink-gkr811-B33"></span><a href="javascript:;" reveal-id="gkr811-B33" data-open="gkr811-B33" class="link link-ref link-reveal xref-bibr">33</a>)</td></tr><tr><td>Spanner</td><td>Homology modeling</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/spanner" target="_blank">pdbj.org/spanner</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B34"></span><a href="javascript:;" reveal-id="gkr811-B34" data-open="gkr811-B34" class="link link-ref link-reveal xref-bibr">34</a>)</td></tr><tr><td>SFAS</td><td>Automated function annotation</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/sfas" target="_blank">pdbj.org/sfas</a></td><td>–</td></tr><tr><td>eF-site</td><td>Electrostatic surface database</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/ef-site" target="_blank">pdbj.org/ef-site</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B28"></span><a href="javascript:;" reveal-id="gkr811-B28" data-open="gkr811-B28" class="link link-ref link-reveal xref-bibr">28</a>,<span class="xrefLink" id="jumplink-gkr811-B35"></span><a href="javascript:;" reveal-id="gkr811-B35" data-open="gkr811-B35" class="link link-ref link-reveal xref-bibr">35</a>)</td></tr><tr><td>eF-seek</td><td>Search against eF-site</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/ef-seek" target="_blank">pdbj.org/ef-seek</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B36"></span><a href="javascript:;" reveal-id="gkr811-B36" data-open="gkr811-B36" class="link link-ref link-reveal xref-bibr">36</a>)</td></tr><tr><td>eF-surf</td><td>Building electrostatic surfaces</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/ef-surf" target="_blank">pdbj.org/ef-surf</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B36"></span><a href="javascript:;" reveal-id="gkr811-B36" data-open="gkr811-B36" class="link link-ref link-reveal xref-bibr">36</a>)</td></tr><tr><td>ProMode</td><td>Database of normal mode analyses of proteins</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/promode" target="_blank">pdbj.org/promode</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B37"></span><a href="javascript:;" reveal-id="gkr811-B37" data-open="gkr811-B37" class="link link-ref link-reveal xref-bibr">37</a>)</td></tr><tr><td>ProMode Elastic</td><td>ProMode with elastic network model</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/promode_elastic" target="_blank">pdbj.org/promode_elastic</a></td><td>–</td></tr><tr><td>ProMode Oligomer</td><td>ProMode for oligomeric proteins</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/promode_oligomer" target="_blank">pdbj.org/promode_oligomer</a></td><td>–</td></tr><tr><td>eProtS</td><td>Educational articles on protein structures</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/eprots" target="_blank">pdbj.org/eprots</a></td><td>–</td></tr><tr><td>Molecule of the Month</td><td>Japanese translation of RCSB PDB MoM</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/mom" target="_blank">pdbj.org/mom</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B3"></span><a href="javascript:;" reveal-id="gkr811-B3" data-open="gkr811-B3" class="link link-ref link-reveal xref-bibr">3</a>)</td></tr></tbody></table></div><div class="table-wrap-foot"><span id="fn-TF1"></span><div content-id="TF1" class="footnote"><span class="fn"><p class="chapter-para"><sup>a</sup>The ‘http://’ prefix is omitted.</p></span></div></div></div></div><div class="table-full-width-wrap"><div class="table-wrap table-wide standard-table"><div class="table-wrap-title" id="gkr811-T1" data-id="gkr811-T1"><span class="label title-label" id="label-12765">Table 1.</span><div class="
 graphic-wrap table-open-button-wrap
 "><a class="fig-view-orig at-tableViewLarge openInAnotherWindow btn js-view-large" role="button" target="_blank" href="
 /view-large/55497372" aria-describedby="label-12765"> Open in new tab </a></div><div class="caption caption-id-" id="caption-12765"><p class="chapter-para">Analysis tools and derived databases</p></div> </div><div class="table-overflow"><table role="table" aria-labelledby="
 label-12765" aria-describedby="
 caption-12765"><thead><tr><th>Service<span aria-hidden="true" style="display: none;"> . </span></th><th>Description<span aria-hidden="true" style="display: none;"> . </span></th><th>URL<span class="xrefLink" id="jumplink-TF1"></span><a href="javascript:;" reveal-id="TF1" data-open="TF1" class="link link-ref link-reveal xref-fn js-xref-fn"><sup>a</sup></a><span aria-hidden="true" style="display: none;"> . </span></th><th>Reference<span aria-hidden="true" style="display: none;"> . </span></th></tr></thead><tbody><tr><td>PDBj Mine</td><td>Simple, advanced and SQL search for PDB data</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/mine" target="_blank">pdbj.org/mine</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B7"></span><a href="javascript:;" reveal-id="gkr811-B7" data-open="gkr811-B7" class="link link-ref link-reveal xref-bibr">7</a>)</td></tr><tr><td>Sequence Navigator</td><td>BLAST (<span class="xrefLink" id="jumplink-gkr811-B22"></span><a href="javascript:;" reveal-id="gkr811-B22" data-open="gkr811-B22" class="link link-ref link-reveal xref-bibr">22</a>) search against PDB</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/seqnavix" target="_blank">pdbj.org/seqnavix</a></td><td>–</td></tr><tr><td>Structure Navigator</td><td>ASH structure similarity search</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/stnavix" target="_blank">pdbj.org/stnavix</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B23"></span><a href="javascript:;" reveal-id="gkr811-B23" data-open="gkr811-B23" class="link link-ref link-reveal xref-bibr">23</a>)</td></tr><tr><td>SeSAW</td><td>Functional site prediction</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/sesaw" target="_blank">pdbj.org/sesaw</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B24"></span><a href="javascript:;" reveal-id="gkr811-B24" data-open="gkr811-B24" class="link link-ref link-reveal xref-bibr">24</a>)</td></tr><tr><td>GIRAF</td><td>Interaction interface similarity search</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/giraf" target="_blank">pdbj.org/giraf</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B25 gkr811-B27"></span><a href="javascript:;" reveal-id="gkr811-B25 gkr811-B27" data-open="gkr811-B25 gkr811-B27" class="link link-ref link-reveal xref-bibr">25–27</a>)</td></tr><tr><td>EM Navigator</td><td>EM structure browser</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/emnavi" target="_blank">pdbj.org/emnavi</a></td><td>–</td></tr><tr><td>jV</td><td>Molecular graphics viewer</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/jv" target="_blank">pdbj.org/jv</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B28"></span><a href="javascript:;" reveal-id="gkr811-B28" data-open="gkr811-B28" class="link link-ref link-reveal xref-bibr">28</a>)</td></tr><tr><td>Yorodumi</td><td>Integrated PDB/EMDB data browser</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/yorodumi" target="_blank">pdbj.org/yorodumi</a></td><td>–</td></tr><tr><td>Protein Globe</td><td>“Protein universe” browser</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/globe" target="_blank">pdbj.org/globe</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B2"></span><a href="javascript:;" reveal-id="gkr811-B2" data-open="gkr811-B2" class="link link-ref link-reveal xref-bibr">2</a>)</td></tr><tr><td>ASH</td><td>Pairwise structure alignment</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/ash" target="_blank">pdbj.org/ash</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B23"></span><a href="javascript:;" reveal-id="gkr811-B23" data-open="gkr811-B23" class="link link-ref link-reveal xref-bibr">23</a>,<span class="xrefLink" id="jumplink-gkr811-B29"></span><a href="javascript:;" reveal-id="gkr811-B29" data-open="gkr811-B29" class="link link-ref link-reveal xref-bibr">29</a>,<span class="xrefLink" id="jumplink-gkr811-B30"></span><a href="javascript:;" reveal-id="gkr811-B30" data-open="gkr811-B30" class="link link-ref link-reveal xref-bibr">30</a>)</td></tr><tr><td>MAFTTash</td><td>Integrated multiple sequence/structure alignment</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/mafftash" target="_blank">pdbj.org/mafftash</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B31"></span><a href="javascript:;" reveal-id="gkr811-B31" data-open="gkr811-B31" class="link link-ref link-reveal xref-bibr">31</a>)</td></tr><tr><td>CRNPRED</td><td>One-dimensional structure prediction</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/crnpred" target="_blank">pdbj.org/crnpred</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B32"></span><a href="javascript:;" reveal-id="gkr811-B32" data-open="gkr811-B32" class="link link-ref link-reveal xref-bibr">32</a>,<span class="xrefLink" id="jumplink-gkr811-B33"></span><a href="javascript:;" reveal-id="gkr811-B33" data-open="gkr811-B33" class="link link-ref link-reveal xref-bibr">33</a>)</td></tr><tr><td>Spanner</td><td>Homology modeling</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/spanner" target="_blank">pdbj.org/spanner</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B34"></span><a href="javascript:;" reveal-id="gkr811-B34" data-open="gkr811-B34" class="link link-ref link-reveal xref-bibr">34</a>)</td></tr><tr><td>SFAS</td><td>Automated function annotation</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/sfas" target="_blank">pdbj.org/sfas</a></td><td>–</td></tr><tr><td>eF-site</td><td>Electrostatic surface database</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/ef-site" target="_blank">pdbj.org/ef-site</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B28"></span><a href="javascript:;" reveal-id="gkr811-B28" data-open="gkr811-B28" class="link link-ref link-reveal xref-bibr">28</a>,<span class="xrefLink" id="jumplink-gkr811-B35"></span><a href="javascript:;" reveal-id="gkr811-B35" data-open="gkr811-B35" class="link link-ref link-reveal xref-bibr">35</a>)</td></tr><tr><td>eF-seek</td><td>Search against eF-site</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/ef-seek" target="_blank">pdbj.org/ef-seek</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B36"></span><a href="javascript:;" reveal-id="gkr811-B36" data-open="gkr811-B36" class="link link-ref link-reveal xref-bibr">36</a>)</td></tr><tr><td>eF-surf</td><td>Building electrostatic surfaces</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/ef-surf" target="_blank">pdbj.org/ef-surf</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B36"></span><a href="javascript:;" reveal-id="gkr811-B36" data-open="gkr811-B36" class="link link-ref link-reveal xref-bibr">36</a>)</td></tr><tr><td>ProMode</td><td>Database of normal mode analyses of proteins</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/promode" target="_blank">pdbj.org/promode</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B37"></span><a href="javascript:;" reveal-id="gkr811-B37" data-open="gkr811-B37" class="link link-ref link-reveal xref-bibr">37</a>)</td></tr><tr><td>ProMode Elastic</td><td>ProMode with elastic network model</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/promode_elastic" target="_blank">pdbj.org/promode_elastic</a></td><td>–</td></tr><tr><td>ProMode Oligomer</td><td>ProMode for oligomeric proteins</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/promode_oligomer" target="_blank">pdbj.org/promode_oligomer</a></td><td>–</td></tr><tr><td>eProtS</td><td>Educational articles on protein structures</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/eprots" target="_blank">pdbj.org/eprots</a></td><td>–</td></tr><tr><td>Molecule of the Month</td><td>Japanese translation of RCSB PDB MoM</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/mom" target="_blank">pdbj.org/mom</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B3"></span><a href="javascript:;" reveal-id="gkr811-B3" data-open="gkr811-B3" class="link link-ref link-reveal xref-bibr">3</a>)</td></tr></tbody></table></div><div class="table-modal"><table><thead><tr><th>Service<span aria-hidden="true" style="display: none;"> . </span></th><th>Description<span aria-hidden="true" style="display: none;"> . </span></th><th>URL<span class="xrefLink" id="jumplink-TF1"></span><a href="javascript:;" reveal-id="TF1" data-open="TF1" class="link link-ref link-reveal xref-fn js-xref-fn"><sup>a</sup></a><span aria-hidden="true" style="display: none;"> . </span></th><th>Reference<span aria-hidden="true" style="display: none;"> . </span></th></tr></thead><tbody><tr><td>PDBj Mine</td><td>Simple, advanced and SQL search for PDB data</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/mine" target="_blank">pdbj.org/mine</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B7"></span><a href="javascript:;" reveal-id="gkr811-B7" data-open="gkr811-B7" class="link link-ref link-reveal xref-bibr">7</a>)</td></tr><tr><td>Sequence Navigator</td><td>BLAST (<span class="xrefLink" id="jumplink-gkr811-B22"></span><a href="javascript:;" reveal-id="gkr811-B22" data-open="gkr811-B22" class="link link-ref link-reveal xref-bibr">22</a>) search against PDB</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/seqnavix" target="_blank">pdbj.org/seqnavix</a></td><td>–</td></tr><tr><td>Structure Navigator</td><td>ASH structure similarity search</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/stnavix" target="_blank">pdbj.org/stnavix</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B23"></span><a href="javascript:;" reveal-id="gkr811-B23" data-open="gkr811-B23" class="link link-ref link-reveal xref-bibr">23</a>)</td></tr><tr><td>SeSAW</td><td>Functional site prediction</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/sesaw" target="_blank">pdbj.org/sesaw</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B24"></span><a href="javascript:;" reveal-id="gkr811-B24" data-open="gkr811-B24" class="link link-ref link-reveal xref-bibr">24</a>)</td></tr><tr><td>GIRAF</td><td>Interaction interface similarity search</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/giraf" target="_blank">pdbj.org/giraf</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B25 gkr811-B27"></span><a href="javascript:;" reveal-id="gkr811-B25 gkr811-B27" data-open="gkr811-B25 gkr811-B27" class="link link-ref link-reveal xref-bibr">25–27</a>)</td></tr><tr><td>EM Navigator</td><td>EM structure browser</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/emnavi" target="_blank">pdbj.org/emnavi</a></td><td>–</td></tr><tr><td>jV</td><td>Molecular graphics viewer</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/jv" target="_blank">pdbj.org/jv</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B28"></span><a href="javascript:;" reveal-id="gkr811-B28" data-open="gkr811-B28" class="link link-ref link-reveal xref-bibr">28</a>)</td></tr><tr><td>Yorodumi</td><td>Integrated PDB/EMDB data browser</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/yorodumi" target="_blank">pdbj.org/yorodumi</a></td><td>–</td></tr><tr><td>Protein Globe</td><td>“Protein universe” browser</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/globe" target="_blank">pdbj.org/globe</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B2"></span><a href="javascript:;" reveal-id="gkr811-B2" data-open="gkr811-B2" class="link link-ref link-reveal xref-bibr">2</a>)</td></tr><tr><td>ASH</td><td>Pairwise structure alignment</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/ash" target="_blank">pdbj.org/ash</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B23"></span><a href="javascript:;" reveal-id="gkr811-B23" data-open="gkr811-B23" class="link link-ref link-reveal xref-bibr">23</a>,<span class="xrefLink" id="jumplink-gkr811-B29"></span><a href="javascript:;" reveal-id="gkr811-B29" data-open="gkr811-B29" class="link link-ref link-reveal xref-bibr">29</a>,<span class="xrefLink" id="jumplink-gkr811-B30"></span><a href="javascript:;" reveal-id="gkr811-B30" data-open="gkr811-B30" class="link link-ref link-reveal xref-bibr">30</a>)</td></tr><tr><td>MAFTTash</td><td>Integrated multiple sequence/structure alignment</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/mafftash" target="_blank">pdbj.org/mafftash</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B31"></span><a href="javascript:;" reveal-id="gkr811-B31" data-open="gkr811-B31" class="link link-ref link-reveal xref-bibr">31</a>)</td></tr><tr><td>CRNPRED</td><td>One-dimensional structure prediction</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/crnpred" target="_blank">pdbj.org/crnpred</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B32"></span><a href="javascript:;" reveal-id="gkr811-B32" data-open="gkr811-B32" class="link link-ref link-reveal xref-bibr">32</a>,<span class="xrefLink" id="jumplink-gkr811-B33"></span><a href="javascript:;" reveal-id="gkr811-B33" data-open="gkr811-B33" class="link link-ref link-reveal xref-bibr">33</a>)</td></tr><tr><td>Spanner</td><td>Homology modeling</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/spanner" target="_blank">pdbj.org/spanner</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B34"></span><a href="javascript:;" reveal-id="gkr811-B34" data-open="gkr811-B34" class="link link-ref link-reveal xref-bibr">34</a>)</td></tr><tr><td>SFAS</td><td>Automated function annotation</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/sfas" target="_blank">pdbj.org/sfas</a></td><td>–</td></tr><tr><td>eF-site</td><td>Electrostatic surface database</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/ef-site" target="_blank">pdbj.org/ef-site</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B28"></span><a href="javascript:;" reveal-id="gkr811-B28" data-open="gkr811-B28" class="link link-ref link-reveal xref-bibr">28</a>,<span class="xrefLink" id="jumplink-gkr811-B35"></span><a href="javascript:;" reveal-id="gkr811-B35" data-open="gkr811-B35" class="link link-ref link-reveal xref-bibr">35</a>)</td></tr><tr><td>eF-seek</td><td>Search against eF-site</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/ef-seek" target="_blank">pdbj.org/ef-seek</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B36"></span><a href="javascript:;" reveal-id="gkr811-B36" data-open="gkr811-B36" class="link link-ref link-reveal xref-bibr">36</a>)</td></tr><tr><td>eF-surf</td><td>Building electrostatic surfaces</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/ef-surf" target="_blank">pdbj.org/ef-surf</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B36"></span><a href="javascript:;" reveal-id="gkr811-B36" data-open="gkr811-B36" class="link link-ref link-reveal xref-bibr">36</a>)</td></tr><tr><td>ProMode</td><td>Database of normal mode analyses of proteins</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/promode" target="_blank">pdbj.org/promode</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B37"></span><a href="javascript:;" reveal-id="gkr811-B37" data-open="gkr811-B37" class="link link-ref link-reveal xref-bibr">37</a>)</td></tr><tr><td>ProMode Elastic</td><td>ProMode with elastic network model</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/promode_elastic" target="_blank">pdbj.org/promode_elastic</a></td><td>–</td></tr><tr><td>ProMode Oligomer</td><td>ProMode for oligomeric proteins</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/promode_oligomer" target="_blank">pdbj.org/promode_oligomer</a></td><td>–</td></tr><tr><td>eProtS</td><td>Educational articles on protein structures</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/eprots" target="_blank">pdbj.org/eprots</a></td><td>–</td></tr><tr><td>Molecule of the Month</td><td>Japanese translation of RCSB PDB MoM</td><td><a class="link link-uri openInAnotherWindow" href="http://pdbj.org/mom" target="_blank">pdbj.org/mom</a></td><td>(<span class="xrefLink" id="jumplink-gkr811-B3"></span><a href="javascript:;" reveal-id="gkr811-B3" data-open="gkr811-B3" class="link link-ref link-reveal xref-bibr">3</a>)</td></tr></tbody></table></div><div class="table-wrap-foot"><span id="fn-TF1"></span><div content-id="TF1" class="footnote"><span class="fn"><p class="chapter-para"><sup>a</sup>The ‘http://’ prefix is omitted.</p></span></div></div></div></div> <h3 scrollto-destination=55497373 id="55497373" class="section-title js-splitscreen-section-title" >Yorodumi and EM Navigator: integration with electron microscopy structures</h3> <p class="chapter-para">In addition to the simple summary page for each entry, PDBj also provides a more feature-rich entry-wise interface called Yorodumi (<span class="xrefLink" id="jumplink-gkr811-F3"></span><a href="javascript:;" data-modal-source-id="gkr811-F3" class="link xref-fig">Figure 3</a>A, <a class="link link-uri openInAnotherWindow" href="http://pdbj.org/yorodumi/" target="_blank">http://pdbj.org/yorodumi/</a>). Yorodumi is an interactive and integrated interface for browsing 3D structure data not only in the PDB but also in the EMDB (Electron Microscopy Data Bank, <a class="link link-uri openInAnotherWindow" href="http://www.ebi.ac.uk/pdbe/emdb/" target="_blank">http://www.ebi.ac.uk/pdbe/emdb/</a>) (<span class="xrefLink" id="jumplink-gkr811-B38"></span><a href="javascript:;" reveal-id="gkr811-B38" data-open="gkr811-B38" class="link link-ref link-reveal xref-bibr">38</a>). The user can select either Jmol (<span class="xrefLink" id="jumplink-gkr811-B39"></span><a href="javascript:;" reveal-id="gkr811-B39" data-open="gkr811-B39" class="link link-ref link-reveal xref-bibr">39</a>) or jV (<span class="xrefLink" id="jumplink-gkr811-B28"></span><a href="javascript:;" reveal-id="gkr811-B28" data-open="gkr811-B28" class="link link-ref link-reveal xref-bibr">28</a>) Java applets for interactive molecular graphics. In the pages for PDB data entries, the user can easily find biologically relevant parts in the entry as recorded in the PDB data, such as subunits, ligand-binding residues, regions with some specific sequences. Yorodumi also supports displaying ‘biological assembly’ including ‘split entries’ (large structures which are determined in a single experiment, but are released as multiple PDB entries due to the limitations of the legacy PDB format). In the EMDB entry pages, the user can interactively view polygon representations of the 3D map iso-surfaces. For the EMDB-PDB hybrid data, which carries atomic models fitted to the EM map data, Yorodumi can show the superimposed view of the data from the both databanks. </p> <a id="55497375" scrollto-destination="55497375"></a> <div data-id="gkr811-f3" data-content-id="gkr811-f3" class="fig fig-section js-fig-section" swap-content-for-modal="true"><div class="graphic-wrap"><img class="content-image" src="https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/nar/40/D1/10.1093_nar_gkr811/2/m_gkr811f3.jpeg?Expires=1736286153&Signature=pLykPzNgZIT5-dlIZ9iULTMzxYedHd14-mFS8G4FZGGiBilNj6kYy1d7INGiHH9UgwnAjROQwafN1ICa9GvKokCaIKZHOB800ee6qkTjotE0DNZCKmCSyzzgAWov6wsIfNYTCa8cEP~b0KsgJnxSiryevIzhzifzy8eaYMCQYm7jnsojUoWloRX9-6xCiHHBrvws1N6ly~M5lYd0qHGAMMyJNcRAaJEtqtg~WjgBa6u7m2dN6nWX~MrTYeevPy-8e4KiF7A9fhODtbv4dkSZUmVaU770UzQ6pM7e-0v599r4kvrkEKTy5GY~1rxTXLSpGPFiM0BNHTg9NFlM1J99yg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA" alt="Yorodumi and EM Navigator. (A) Yorodumi displaying an EMDB-PDB hybrid data, EMDB-5168 and PDB 3MFP (helical assembly) (40). (B) EM Navigator gallery page." data-path-from-xml="gkr811f3.jpeg" /><div class="graphic-bottom"><div class="label fig-label" id="label-55497375">Figure 3.</div><div class="caption fig-caption"><p class="chapter-para">Yorodumi and EM Navigator. (<strong>A</strong>) Yorodumi displaying an EMDB-PDB hybrid data, EMDB-5168 and PDB 3MFP (helical assembly) (<span class="xrefLink" id="jumplink-gkr811-B40"></span><a href="javascript:;" reveal-id="gkr811-B40" data-open="gkr811-B40" class="link link-ref link-reveal xref-bibr">40</a>). (<strong>B</strong>) EM Navigator gallery page.</p></div><div class="ajax-articleAbstract-exclude-regex fig-orig original-slide figure-button-wrap"><a class="fig-view-orig js-view-large at-figureViewLarge openInAnotherWindow" role="button" aria-describedby="label-55497375" href="/view-large/figure/55497375/gkr811f3.jpeg" data-path-from-xml="gkr811f3.jpeg" target="_blank">Open in new tab</a><a class="download-slide" role="button" aria-describedby="label-55497375" data-section="55497375" href="/DownloadFile/DownloadImage.aspx?image=https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/nar/40/D1/10.1093_nar_gkr811/2/gkr811f3.jpeg?Expires=1736286153&Signature=Ai0HBgv5Rl~vKspkmQGh5jK6iCstWfYe-UR2cE5ZphCvMl0D2ktAxMWda3Gh12d4160e3w12xPhDkrkHjubjNefwQ40dW-6Kyxqub3rnjBIukv2QtMsIa25pgl09eFo9v~NjBxFAY7EdJH-FSfSjrAVvvt3j6a4W1yCS3DGVdb-O-vivVHpemdrbSiuD-kaiDAv6Tzg1M47AVe524HKQfAm7QUgACjxcA2hL7ijt79PK2qxXBs2~iwT8B-OZ2UxOLOZOpGpxBdo2O~tVelUgTc49mWIMcMkWEVTjBGWm~Wc4k0RR5xFjtAJ-KBOG69I1XfON9XX8G2YGKi3QpXsqtg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA&sec=55497375&ar=2903417&xsltPath=~/UI/app/XSLT&imagename=&siteId=5127" data-path-from-xml="gkr811f3.jpeg">Download slide</a></div></div></div></div><p class="chapter-para">Since electron microscopy is increasingly becoming important as a structure determination method, especially for very large molecular complexes, we also provide EM Navigator, a tool that is specifically designed to explore electron microscopy (EM) structure data deposited in the EMDB (<span class="xrefLink" id="jumplink-gkr811-B38"></span><a href="javascript:;" reveal-id="gkr811-B38" data-open="gkr811-B38" class="link link-ref link-reveal xref-bibr">38</a>). To view EMDB 3D map data easily, movies of 3D structure models rolling along horizontal and vertical axes are provided. They are shown in iso-surface representations for typical 3D map data or in solid representations for noisy structure data such as electron tomograms. When atomic models are available in the PDB, they are superimposed on lower resolution EM maps. In the details page of EMDB entries, one or more movies are displayed together with metadata information. In the results of keyword searches, the user can customize the kinds of displayed information such as names of the microscopy or software packages used in the experiments in tabular format. In the gallery page, the user can see the snapshot images of all the released EM structures at a glance (<span class="xrefLink" id="jumplink-gkr811-F3"></span><a href="javascript:;" data-modal-source-id="gkr811-F3" class="link xref-fig">Figure 3</a>B).</p> <h2 scrollto-destination=55497377 id="55497377" class="section-title js-splitscreen-section-title" >FUNDING</h2> <p class="chapter-para">Funding for open access charge: National Bioscience Database Center, the Japan Science and Technology Agency.</p><p class="chapter-para"><em>Conflict of interest statement</em>. None declared.</p> <h2 scrollto-destination=55497380 id="55497380" class="backacknowledgements-title js-splitscreen-backacknowledgements-title" >ACKNOWLEDGEMENTS</h2> <p class="chapter-para">We thank Vladimir Guranovic and John Westbrook for helping with the PDBML schema.</p> <h2 scrollto-destination=55497382 id="55497382" class="backreferences-title js-splitscreen-backreferences-title" >REFERENCES</h2> <div class="ref-list js-splitview-ref-list"><div content-id="gkr811-B1" class="js-splitview-ref-item" data-legacy-id="gkr811-B1"><div class="refLink-parent"><span class="refLink"><a name="jumplink-gkr811-B1" href="javascript:;" aria-label="jumplink-gkr811-B1" data-id=""></a></span></div><div class="ref false"><div id="ref-auto-gkr811-B1" class="ref-content " data-id="gkr811-B1"><span class="label title-label">1</span><div class="citation element-citation"><span class="person-group"><div class="name"><div class="surname">Berman</div> <div class="given-names">H</div></div> <div class="name"><div class="surname">Henrick</div> <div class="given-names">K</div></div> <div class="name"><div class="surname">Nakamura</div> <div class="given-names">H</div></div> <div class="name"><div class="surname">Markley</div> <div class="given-names">JL</div></div></span><div class="article-title">The worldwide Protein Data Bank (wwPDB): ensuring a single, uniform archive of PDB data</div>, <div class="source ">Nucleic Acids Res.</div>, <div class="year">2007</div>, vol. <div class="volume">35</div> (pg. <div class="fpage">D301</div>-<div class="lpage">D303</div>)<div class="citation-links"></div><div class="citation-links"><p class="citation-links-compatibility"><span class="google-scholar-ref-link"><a class="openInAnotherWindow" href="https://scholar.google.com/scholar_lookup?title=The%20worldwide%20Protein%20Data%20Bank%20%28wwPDB%29%3A%20ensuring%20a%20single%2C%20uniform%20archive%20of%20PDB%20data&author=H%20Berman&author=K%20Henrick&author=H%20Nakamura&author=JL%20Markley&publication_year=2007&journal=Nucleic%20Acids%20Res.&volume=35&pages=D301-D303" target="_blank">Google Scholar</a></span></p><div class="crossref-doi js-ref-link"><a class="openInAnotherWindow" href="http://dx.doi.org/10.1093/nar/gkl971" target="_blank">Crossref</a></div><div class="adsDoiReference hide"><a class="openInAnotherWindow" href="http://adsabs.harvard.edu/cgi-bin/basic_connect?qsearch=10.1093%2Fnar%2Fgkl971" target="_blank">Search ADS</a></div><div class="xslopenurl empty-target"><span class="inst-open-url-holders" data-targetId="10.1093%2Fnar%2Fgkl971"> </span></div><div class="pub-id"><a href="http://www.ncbi.nlm.nih.gov/pubmed/17142228" class="link link-pub-id openInAnotherWindow" target="_blank">PubMed</a></div><p class="citation-links-compatibility"><span class="worldcat-reference-ref-link js-worldcat-preview-ref-link" style="display:none"><a class="openInAnotherWindow" href="https://www.worldcat.org/search?q=ti:The%20worldwide%20Protein%20Data%20Bank%20%28wwPDB%29%3A%20ensuring%20a%20single%2C%20uniform%20archive%20of%20PDB%20data&qt=advanced&dblist=638" target="_blank">WorldCat</a></span></p> </div></div></div></div></div><div content-id="gkr811-B2" class="js-splitview-ref-item" data-legacy-id="gkr811-B2"><div class="refLink-parent"><span class="refLink"><a name="jumplink-gkr811-B2" href="javascript:;" aria-label="jumplink-gkr811-B2" data-id=""></a></span></div><div class="ref false"><div id="ref-auto-gkr811-B2" class="ref-content " data-id="gkr811-B2"><span class="label title-label">2</span><div class="citation element-citation"><span class="person-group"><div class="name"><div class="surname">Standley</div> <div class="given-names">DM</div></div> <div class="name"><div class="surname">Kinjo</div> <div class="given-names">AR</div></div> <div class="name"><div class="surname">Kinoshita</div> <div class="given-names">K</div></div> <div class="name"><div class="surname">Nakamura</div> <div class="given-names">H</div></div></span><div class="article-title">Protein structure databases with new web services for structural biology and biomedical research</div>, <div class="source ">Brief. 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Protein Data Bank Japan (PDBj): maintaining a structural data archive and resource description framework format | Nucleic Acids Research | Oxford Academic