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class="left-panel-container"><div class="user-info-component-wrapper"><div class="user-summary-cta-container"><div class="user-summary-container"><div class="social-profile-avatar-container"><img class="profile-avatar u-positionAbsolute" alt="Michael Binks" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/147569031/133356181/122785845/s200_michael.binks.png" /></div><div class="title-container"><h1 class="ds2-5-heading-sans-serif-sm">Michael Binks</h1><div class="affiliations-container fake-truncate js-profile-affiliations"></div></div></div><div class="sidebar-cta-container"><button class="ds2-5-button hidden profile-cta-button grow js-profile-follow-button" data-broccoli-component="user-info.follow-button" data-click-track="profile-user-info-follow-button" data-follow-user-fname="Michael" data-follow-user-id="147569031" 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class="data"><span class="js-profile-view-count"></span></p></div></span></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="147569031" href="https://www.academia.edu/Documents/in/Blood_Coagulation"><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://independent.academia.edu/MichaelBinks","location":"/MichaelBinks","scheme":"https","host":"independent.academia.edu","port":null,"pathname":"/MichaelBinks","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Blood Coagulation"]}" data-trace="false" data-dom-id="Pill-react-component-f9e65e42-06c0-40a2-a045-1d14aeb522a9"></div> <div id="Pill-react-component-f9e65e42-06c0-40a2-a045-1d14aeb522a9"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="147569031" href="https://www.academia.edu/Documents/in/Leukemia"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Leukemia"]}" data-trace="false" data-dom-id="Pill-react-component-301c5c2b-73d0-4151-b909-bc541426131e"></div> <div id="Pill-react-component-301c5c2b-73d0-4151-b909-bc541426131e"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="147569031" href="https://www.academia.edu/Documents/in/Newborn_Infant"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Newborn Infant"]}" data-trace="false" data-dom-id="Pill-react-component-706a3bf0-4c5e-421e-8b78-521199004b4c"></div> <div id="Pill-react-component-706a3bf0-4c5e-421e-8b78-521199004b4c"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="147569031" href="https://www.academia.edu/Documents/in/Medicine_and_Health_Sciences"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Medicine and Health Sciences"]}" data-trace="false" data-dom-id="Pill-react-component-03432d0d-c9a1-4aeb-a9a9-9a25946189b1"></div> <div id="Pill-react-component-03432d0d-c9a1-4aeb-a9a9-9a25946189b1"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="147569031" href="https://www.academia.edu/Documents/in/Hematology"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Hematology"]}" data-trace="false" data-dom-id="Pill-react-component-7979b095-c374-4c02-846f-86fd5592bff7"></div> <div id="Pill-react-component-7979b095-c374-4c02-846f-86fd5592bff7"></div> </a></div></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Michael Binks</h3></div><div class="js-work-strip profile--work_container" data-work-id="47950088"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/47950088/Recent_advances_in_understanding_the_natural_history_of_the_otitis_media_microbiome_and_its_response_to_environmental_pressures"><img alt="Research paper thumbnail of Recent advances in understanding the natural history of the otitis media microbiome and its response to environmental pressures" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/47950088/Recent_advances_in_understanding_the_natural_history_of_the_otitis_media_microbiome_and_its_response_to_environmental_pressures">Recent advances in understanding the natural history of the otitis media microbiome and its response to environmental pressures</a></div><div class="wp-workCard_item"><span>International Journal of Pediatric Otorhinolaryngology</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="47950088"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="47950088"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 47950088; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); 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})(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=47950088]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":47950088,"title":"Recent advances in understanding the natural history of the otitis media microbiome and its response to environmental pressures","translated_title":"","metadata":{"publisher":"Elsevier BV","publication_name":"International Journal of Pediatric 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antibiotics vs placebo for exacerbations of paediatric bronchiectasis" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/47950087/Oral_antibiotics_vs_placebo_for_exacerbations_of_paediatric_bronchiectasis">Oral antibiotics vs placebo for exacerbations of paediatric bronchiectasis</a></div><div class="wp-workCard_item"><span>Acute critical care</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="47950087"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="47950087"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 47950087; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=47950087]").text(description); $(".js-view-count[data-work-id=47950087]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 47950087; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='47950087']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 47950087, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=47950087]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":47950087,"title":"Oral antibiotics vs placebo for exacerbations of paediatric bronchiectasis","translated_title":"","metadata":{"publisher":"European Respiratory Society","publication_name":"Acute critical 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/></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/47950086/Safety_equity_and_monitoring_A_review_of_the_gaps_in_maternal_vaccination_strategies_for_Aboriginal_and_Torres_Strait_Islander_women">Safety, equity and monitoring: A review of the gaps in maternal vaccination strategies for Aboriginal and Torres Strait Islander women</a></div><div class="wp-workCard_item"><span>Human Vaccines & Immunotherapeutics</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="47950086"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="47950086"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 47950086; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=47950086]").text(description); $(".js-view-count[data-work-id=47950086]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 47950086; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='47950086']"); 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women" class="work-thumbnail" src="https://attachments.academia-assets.com/66816015/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/47950085/_Links2HealthierBubs_cohort_study_protocol_for_a_record_linkage_study_on_the_safety_uptake_and_effectiveness_of_influenza_and_pertussis_vaccines_among_pregnant_Australian_women">‘Links2HealthierBubs’ cohort study: protocol for a record linkage study on the safety, uptake and effectiveness of influenza and pertussis vaccines among pregnant Australian women</a></div><div class="wp-workCard_item"><span>BMJ Open</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">IntroductionPregnant women and infants are at risk of severe influenza and pertussis infection. I...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">IntroductionPregnant women and infants are at risk of severe influenza and pertussis infection. Inactivated influenza vaccine (IIV) and diphtheria-tetanus-acellular pertussis vaccine (dTpa) are recommended during pregnancy to protect both mothers and infants. In Australia, uptake is not routinely monitored but coverage appears sub-optimal. Evidence on the safety of combined antenatal IIV and dTpa is fragmented or deficient, and there remain knowledge gaps of population-level vaccine effectiveness. We aim to establish a large, population-based, multi-jurisdictional cohort of mother-infant pairs to measure the uptake, safety and effectiveness of antenatal IIV and dTpa vaccines in three Australian jurisdictions. This is a first step toward assessing the impact of antenatal vaccination programmes in Australia, which can then inform government policy with respect to future strategies in national vaccination programmes.Methods and analysis‘Links2HealthierBubs’ is an observational, populat...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7ea9f6394f9a49ea5ab522b58a8c4af1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":66816015,"asset_id":47950085,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/66816015/download_file?st=MTczMzA3OTIyOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="47950085"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="47950085"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 47950085; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=47950085]").text(description); $(".js-view-count[data-work-id=47950085]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 47950085; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='47950085']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 47950085, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7ea9f6394f9a49ea5ab522b58a8c4af1" } } $('.js-work-strip[data-work-id=47950085]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":47950085,"title":"‘Links2HealthierBubs’ cohort study: protocol for a record linkage study on the safety, uptake and effectiveness of influenza and pertussis vaccines among pregnant Australian women","translated_title":"","metadata":{"abstract":"IntroductionPregnant women and infants are at risk of severe influenza and pertussis infection. Inactivated influenza vaccine (IIV) and diphtheria-tetanus-acellular pertussis vaccine (dTpa) are recommended during pregnancy to protect both mothers and infants. In Australia, uptake is not routinely monitored but coverage appears sub-optimal. Evidence on the safety of combined antenatal IIV and dTpa is fragmented or deficient, and there remain knowledge gaps of population-level vaccine effectiveness. We aim to establish a large, population-based, multi-jurisdictional cohort of mother-infant pairs to measure the uptake, safety and effectiveness of antenatal IIV and dTpa vaccines in three Australian jurisdictions. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="47950084"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/47950084/Birth_outcomes_in_Aboriginal_mother_infant_pairs_from_the_Northern_Territory_Australia_who_received_23_valent_polysaccharide_pneumococcal_vaccination_during_pregnancy_2006_2011_The_PneuMum_randomised_controlled_trial"><img alt="Research paper thumbnail of Birth outcomes in Aboriginal mother–infant pairs from the Northern Territory, Australia, who received 23‐valent polysaccharide pneumococcal vaccination during pregnancy, 2006–2011: The PneuMum randomised controlled trial" class="work-thumbnail" src="https://attachments.academia-assets.com/66816017/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/47950084/Birth_outcomes_in_Aboriginal_mother_infant_pairs_from_the_Northern_Territory_Australia_who_received_23_valent_polysaccharide_pneumococcal_vaccination_during_pregnancy_2006_2011_The_PneuMum_randomised_controlled_trial">Birth outcomes in Aboriginal mother–infant pairs from the Northern Territory, Australia, who received 23‐valent polysaccharide pneumococcal vaccination during pregnancy, 2006–2011: The PneuMum randomised controlled trial</a></div><div class="wp-workCard_item"><span>Australian and New Zealand Journal of Obstetrics and Gynaecology</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="069717a4e05f3ca5cd7ee66ca4239082" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":66816017,"asset_id":47950084,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/66816017/download_file?st=MTczMzA3OTIyOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="47950084"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="47950084"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 47950084; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="47950082"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/47950082/Amoxicillin_clavulanate_versus_azithromycin_for_respiratory_exacerbations_in_children_with_bronchiectasis_BEST_2_a_multicentre_double_blind_non_inferiority_randomised_controlled_trial"><img alt="Research paper thumbnail of Amoxicillin-clavulanate versus azithromycin for respiratory exacerbations in children with bronchiectasis (BEST-2): a multicentre, double-blind, non-inferiority, randomised controlled trial" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/47950082/Amoxicillin_clavulanate_versus_azithromycin_for_respiratory_exacerbations_in_children_with_bronchiectasis_BEST_2_a_multicentre_double_blind_non_inferiority_randomised_controlled_trial">Amoxicillin-clavulanate versus azithromycin for respiratory exacerbations in children with bronchiectasis (BEST-2): a multicentre, double-blind, non-inferiority, randomised controlled trial</a></div><div class="wp-workCard_item"><span>Lancet (London, England)</span><span>, Oct 6, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Although amoxicillin-clavulanate is the recommended first-line empirical oral antibiotic treatmen...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Although amoxicillin-clavulanate is the recommended first-line empirical oral antibiotic treatment for non-severe exacerbations in children with bronchiectasis, azithromycin is also often prescribed for its convenient once-daily dosing. No randomised controlled trials involving acute exacerbations in children with bronchiectasis have been published to our knowledge. We hypothesised that azithromycin is non-inferior to amoxicillin-clavulanate for resolving exacerbations in children with bronchiectasis. We did this parallel-group, double-dummy, double-blind, non-inferiority randomised controlled trial in three Australian and one New Zealand hospital between April, 2012, and August, 2016. We enrolled children aged 1-19 years with radiographically proven bronchiectasis unrelated to cystic fibrosis. At the start of an exacerbation, children were randomly assigned to oral suspensions of either amoxicillin-clavulanate (22·5 mg/kg, twice daily) and placebo or azithromycin (5 mg/kg per day) ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="47950082"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="47950082"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 47950082; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=47950082]").text(description); $(".js-view-count[data-work-id=47950082]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 47950082; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='47950082']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 47950082, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=47950082]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":47950082,"title":"Amoxicillin-clavulanate versus azithromycin for respiratory exacerbations in children with bronchiectasis (BEST-2): a multicentre, double-blind, non-inferiority, randomised controlled trial","translated_title":"","metadata":{"abstract":"Although amoxicillin-clavulanate is the recommended first-line empirical oral antibiotic treatment for non-severe exacerbations in children with bronchiectasis, azithromycin is also often prescribed for its convenient once-daily dosing. 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At the start of an exacerbation, children were randomly assigned to oral suspensions of either amoxicillin-clavulanate (22·5 mg/kg, twice daily) and placebo or azithromycin (5 mg/kg per day) ...","publication_date":{"day":6,"month":10,"year":2018,"errors":{}},"publication_name":"Lancet (London, England)"},"translated_abstract":"Although amoxicillin-clavulanate is the recommended first-line empirical oral antibiotic treatment for non-severe exacerbations in children with bronchiectasis, azithromycin is also often prescribed for its convenient once-daily dosing. No randomised controlled trials involving acute exacerbations in children with bronchiectasis have been published to our knowledge. We hypothesised that azithromycin is non-inferior to amoxicillin-clavulanate for resolving exacerbations in children with bronchiectasis. We did this parallel-group, double-dummy, double-blind, non-inferiority randomised controlled trial in three Australian and one New Zealand hospital between April, 2012, and August, 2016. We enrolled children aged 1-19 years with radiographically proven bronchiectasis unrelated to cystic fibrosis. At the start of an exacerbation, children were randomly assigned to oral suspensions of either amoxicillin-clavulanate (22·5 mg/kg, twice daily) and placebo or azithromycin (5 mg/kg per day) ...","internal_url":"https://www.academia.edu/47950082/Amoxicillin_clavulanate_versus_azithromycin_for_respiratory_exacerbations_in_children_with_bronchiectasis_BEST_2_a_multicentre_double_blind_non_inferiority_randomised_controlled_trial","translated_internal_url":"","created_at":"2021-05-03T17:47:14.539-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":147569031,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Amoxicillin_clavulanate_versus_azithromycin_for_respiratory_exacerbations_in_children_with_bronchiectasis_BEST_2_a_multicentre_double_blind_non_inferiority_randomised_controlled_trial","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":147569031,"first_name":"Michael","middle_initials":null,"last_name":"Binks","page_name":"MichaelBinks","domain_name":"independent","created_at":"2020-02-27T19:41:19.082-08:00","display_name":"Michael Binks","url":"https://independent.academia.edu/MichaelBinks"},"attachments":[],"research_interests":[{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome"},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child"},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult"},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant"},{"id":335984,"name":"Anti-Bacterial Agents","url":"https://www.academia.edu/Documents/in/Anti-Bacterial_Agents"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors"},{"id":584615,"name":"Disease Progression","url":"https://www.academia.edu/Documents/in/Disease_Progression"},{"id":589804,"name":"Bronchiectasis","url":"https://www.academia.edu/Documents/in/Bronchiectasis"},{"id":856412,"name":"Azithromycin","url":"https://www.academia.edu/Documents/in/Azithromycin"},{"id":2489700,"name":"Child preschool","url":"https://www.academia.edu/Documents/in/Child_preschool"},{"id":3094070,"name":"The Lancet","url":"https://www.academia.edu/Documents/in/The_Lancet"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="47950081"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/47950081/Bacteria_and_viruses_in_the_nasopharynx_immediately_prior_to_onset_of_acute_lower_respiratory_infections_in_Indigenous_Australian_children"><img alt="Research paper thumbnail of Bacteria and viruses in the nasopharynx immediately prior to onset of acute lower respiratory infections in Indigenous Australian children" class="work-thumbnail" src="https://attachments.academia-assets.com/66816008/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/47950081/Bacteria_and_viruses_in_the_nasopharynx_immediately_prior_to_onset_of_acute_lower_respiratory_infections_in_Indigenous_Australian_children">Bacteria and viruses in the nasopharynx immediately prior to onset of acute lower respiratory infections in Indigenous Australian children</a></div><div class="wp-workCard_item"><span>European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology</span><span>, Jan 29, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Acute lower respiratory infection (ALRI) is a major cause of hospitalization for Indigenous child...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Acute lower respiratory infection (ALRI) is a major cause of hospitalization for Indigenous children in remote regions of Australia. The associated microbiology remains unclear. Our aim was to determine whether the microbes present in the nasopharynx before an ALRI were associated with its onset. A retrospective case-control/crossover study among Indigenous children aged up to 2 years. ALRI cases identified by medical note review were eligible where nasopharyngeal swabs were available: (1) 0-21 days before ALRI onset (case); (2) 90-180 days before ALRI onset (same child controls); and (3) from time and age-matched children without ALRI (different child controls). PCR assays determined the presence and/or load of selected respiratory pathogens. Among 104 children (182 recorded ALRI episodes), 120 case-same child control and 170 case-different child control swab pairs were identified. Human adenoviruses (HAdV) were more prevalent in cases compared to same child controls (18 vs 7%; OR ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1e2501397884c5424347ad4f6bb24f40" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":66816008,"asset_id":47950081,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/66816008/download_file?st=MTczMzA3OTIyOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="47950081"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="47950081"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 47950081; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=47950081]").text(description); $(".js-view-count[data-work-id=47950081]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 47950081; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='47950081']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 47950081, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1e2501397884c5424347ad4f6bb24f40" } } $('.js-work-strip[data-work-id=47950081]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":47950081,"title":"Bacteria and viruses in the nasopharynx immediately prior to onset of acute lower respiratory infections in Indigenous Australian children","translated_title":"","metadata":{"abstract":"Acute lower respiratory infection (ALRI) is a major cause of hospitalization for Indigenous children in remote regions of Australia. The associated microbiology remains unclear. Our aim was to determine whether the microbes present in the nasopharynx before an ALRI were associated with its onset. A retrospective case-control/crossover study among Indigenous children aged up to 2 years. ALRI cases identified by medical note review were eligible where nasopharyngeal swabs were available: (1) 0-21 days before ALRI onset (case); (2) 90-180 days before ALRI onset (same child controls); and (3) from time and age-matched children without ALRI (different child controls). PCR assays determined the presence and/or load of selected respiratory pathogens. Among 104 children (182 recorded ALRI episodes), 120 case-same child control and 170 case-different child control swab pairs were identified. Human adenoviruses (HAdV) were more prevalent in cases compared to same child controls (18 vs 7%; OR ...","publication_date":{"day":29,"month":1,"year":2018,"errors":{}},"publication_name":"European journal of clinical microbiology \u0026 infectious diseases : official publication of the European Society of Clinical Microbiology"},"translated_abstract":"Acute lower respiratory infection (ALRI) is a major cause of hospitalization for Indigenous children in remote regions of Australia. The associated microbiology remains unclear. Our aim was to determine whether the microbes present in the nasopharynx before an ALRI were associated with its onset. A retrospective case-control/crossover study among Indigenous children aged up to 2 years. ALRI cases identified by medical note review were eligible where nasopharyngeal swabs were available: (1) 0-21 days before ALRI onset (case); (2) 90-180 days before ALRI onset (same child controls); and (3) from time and age-matched children without ALRI (different child controls). PCR assays determined the presence and/or load of selected respiratory pathogens. Among 104 children (182 recorded ALRI episodes), 120 case-same child control and 170 case-different child control swab pairs were identified. Human adenoviruses (HAdV) were more prevalent in cases compared to same child controls (18 vs 7%; OR ...","internal_url":"https://www.academia.edu/47950081/Bacteria_and_viruses_in_the_nasopharynx_immediately_prior_to_onset_of_acute_lower_respiratory_infections_in_Indigenous_Australian_children","translated_internal_url":"","created_at":"2021-05-03T17:47:14.463-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":147569031,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":66816008,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/66816008/thumbnails/1.jpg","file_name":"s10096-018-3314-7.pdf","download_url":"https://www.academia.edu/attachments/66816008/download_file?st=MTczMzA3OTIyOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Bacteria_and_viruses_in_the_nasopharynx.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/66816008/s10096-018-3314-7-libre.pdf?1620091722=\u0026response-content-disposition=attachment%3B+filename%3DBacteria_and_viruses_in_the_nasopharynx.pdf\u0026Expires=1733082828\u0026Signature=YGyU4qikBB5T8rI4ZbU6NVU44B4SOhze-2PYZ-KlrgXTjCCW~NorI2DBE-vyXXA8Jz9i9GHHBmNx61xAfaaHTe8qfjgi~uKnNUVQ-9S7-MC1mjDnpcFxu9UUbu9F2kV3JVunvUHfCnIkEfAG95jF56W2FC1XiTlLjQT3hLCQWdr5QeXjVapURaA77uYw08f7F4qocdssWYDjrXMG0BYWFXQsRq7bN7ANzQnzZ86ALD8duQpb7vMW2T-Nkpc93R6kOF7GnUisehbJVFIv-SZ1c17XIPRgPwEat8VUeVXg8fVCJAXIWxaiX58~uqpFUWS2EK0cQbqJ11d-KAaOQ4Qf9w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Bacteria_and_viruses_in_the_nasopharynx_immediately_prior_to_onset_of_acute_lower_respiratory_infections_in_Indigenous_Australian_children","translated_slug":"","page_count":10,"language":"en","content_type":"Work","owner":{"id":147569031,"first_name":"Michael","middle_initials":null,"last_name":"Binks","page_name":"MichaelBinks","domain_name":"independent","created_at":"2020-02-27T19:41:19.082-08:00","display_name":"Michael Binks","url":"https://independent.academia.edu/MichaelBinks"},"attachments":[{"id":66816008,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/66816008/thumbnails/1.jpg","file_name":"s10096-018-3314-7.pdf","download_url":"https://www.academia.edu/attachments/66816008/download_file?st=MTczMzA3OTIyOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Bacteria_and_viruses_in_the_nasopharynx.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/66816008/s10096-018-3314-7-libre.pdf?1620091722=\u0026response-content-disposition=attachment%3B+filename%3DBacteria_and_viruses_in_the_nasopharynx.pdf\u0026Expires=1733082828\u0026Signature=YGyU4qikBB5T8rI4ZbU6NVU44B4SOhze-2PYZ-KlrgXTjCCW~NorI2DBE-vyXXA8Jz9i9GHHBmNx61xAfaaHTe8qfjgi~uKnNUVQ-9S7-MC1mjDnpcFxu9UUbu9F2kV3JVunvUHfCnIkEfAG95jF56W2FC1XiTlLjQT3hLCQWdr5QeXjVapURaA77uYw08f7F4qocdssWYDjrXMG0BYWFXQsRq7bN7ANzQnzZ86ALD8duQpb7vMW2T-Nkpc93R6kOF7GnUisehbJVFIv-SZ1c17XIPRgPwEat8VUeVXg8fVCJAXIWxaiX58~uqpFUWS2EK0cQbqJ11d-KAaOQ4Qf9w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="47950080"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/47950080/The_Epidemiology_of_Chronic_Suppurative_Lung_Disease_and_Bronchiectasis_in_Children_and_Adolescents"><img alt="Research paper thumbnail of The Epidemiology of Chronic Suppurative Lung Disease and Bronchiectasis in Children and Adolescents" class="work-thumbnail" src="https://attachments.academia-assets.com/66816004/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/47950080/The_Epidemiology_of_Chronic_Suppurative_Lung_Disease_and_Bronchiectasis_in_Children_and_Adolescents">The Epidemiology of Chronic Suppurative Lung Disease and Bronchiectasis in Children and Adolescents</a></div><div class="wp-workCard_item"><span>Frontiers in pediatrics</span><span>, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In the modern era, the global burden of childhood chronic suppurative lung disease (CSLD) remains...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In the modern era, the global burden of childhood chronic suppurative lung disease (CSLD) remains poorly captured by the literature. What is clear, however, is that CSLD is essentially a disease of poverty. Disadvantaged children from indigenous and low- and middle-income populations had a substantially higher burden of CSLD, generally infectious in etiology and of a more severe nature, than children in high-income countries. A universal issue was the delay in diagnosis and the inconsistent reporting of clinical features. Importantly, infection-related CSLD is largely preventable. A considerable research and clinical effort is needed to identify modifiable risk factors and socioeconomic determinants of CSLD and provide robust evidence to guide optimal prevention and management strategies. The purpose of this review was to update the international literature on the epidemiology, etiology, and clinical features of pediatric CSLD.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="0e2f539638073209261290e23e079305" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":66816004,"asset_id":47950080,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/66816004/download_file?st=MTczMzA3OTIyOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="47950080"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="47950080"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 47950080; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=47950080]").text(description); $(".js-view-count[data-work-id=47950080]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 47950080; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='47950080']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 47950080, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "0e2f539638073209261290e23e079305" } } $('.js-work-strip[data-work-id=47950080]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":47950080,"title":"The Epidemiology of Chronic Suppurative Lung Disease and Bronchiectasis in Children and Adolescents","translated_title":"","metadata":{"abstract":"In the modern era, the global burden of childhood chronic suppurative lung disease (CSLD) remains poorly captured by the literature. What is clear, however, is that CSLD is essentially a disease of poverty. Disadvantaged children from indigenous and low- and middle-income populations had a substantially higher burden of CSLD, generally infectious in etiology and of a more severe nature, than children in high-income countries. A universal issue was the delay in diagnosis and the inconsistent reporting of clinical features. Importantly, infection-related CSLD is largely preventable. A considerable research and clinical effort is needed to identify modifiable risk factors and socioeconomic determinants of CSLD and provide robust evidence to guide optimal prevention and management strategies. The purpose of this review was to update the international literature on the epidemiology, etiology, and clinical features of pediatric CSLD.","publication_date":{"day":null,"month":null,"year":2017,"errors":{}},"publication_name":"Frontiers in pediatrics"},"translated_abstract":"In the modern era, the global burden of childhood chronic suppurative lung disease (CSLD) remains poorly captured by the literature. What is clear, however, is that CSLD is essentially a disease of poverty. Disadvantaged children from indigenous and low- and middle-income populations had a substantially higher burden of CSLD, generally infectious in etiology and of a more severe nature, than children in high-income countries. A universal issue was the delay in diagnosis and the inconsistent reporting of clinical features. Importantly, infection-related CSLD is largely preventable. A considerable research and clinical effort is needed to identify modifiable risk factors and socioeconomic determinants of CSLD and provide robust evidence to guide optimal prevention and management strategies. The purpose of this review was to update the international literature on the epidemiology, etiology, and clinical features of pediatric CSLD.","internal_url":"https://www.academia.edu/47950080/The_Epidemiology_of_Chronic_Suppurative_Lung_Disease_and_Bronchiectasis_in_Children_and_Adolescents","translated_internal_url":"","created_at":"2021-05-03T17:47:14.386-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":147569031,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":66816004,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/66816004/thumbnails/1.jpg","file_name":"a30011f16e9d4722fd15f22d88d4d30ba92a.pdf","download_url":"https://www.academia.edu/attachments/66816004/download_file?st=MTczMzA3OTIyOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"The_Epidemiology_of_Chronic_Suppurative.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/66816004/a30011f16e9d4722fd15f22d88d4d30ba92a-libre.pdf?1620091721=\u0026response-content-disposition=attachment%3B+filename%3DThe_Epidemiology_of_Chronic_Suppurative.pdf\u0026Expires=1733082828\u0026Signature=VS3bCULg8pDob6dxOAfum0Pb94A62pH2XyeCVobicUvzslbW8CBSznxWcFoQSSc5Aw475UCsLKwP7pUI2zneQPf4XwZFIEzlPs0RnLQrJ5GuaYOR55DznXVdO~eqPO3NzMOOjzBxcxUW5BQebwo0uKhts4q5Tt6q9-A7gN~MDjrOPxCrJLt5Xj7bQpt5OW7rgGUxhVUVqQM0dl-OtruogDW6k4tUJc06x7-J-qpN~4EJNRpDi2dBqloTdov5PVAhS7Cnc1XgumzW-nksTd6IHLA1D82f3NII1Yyo2f2O66ltrKMi9a6Nxl0~s8U3RxPQIzf3UmVg9Zl6SoeK4NvrBw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"The_Epidemiology_of_Chronic_Suppurative_Lung_Disease_and_Bronchiectasis_in_Children_and_Adolescents","translated_slug":"","page_count":11,"language":"en","content_type":"Work","owner":{"id":147569031,"first_name":"Michael","middle_initials":null,"last_name":"Binks","page_name":"MichaelBinks","domain_name":"independent","created_at":"2020-02-27T19:41:19.082-08:00","display_name":"Michael Binks","url":"https://independent.academia.edu/MichaelBinks"},"attachments":[{"id":66816004,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/66816004/thumbnails/1.jpg","file_name":"a30011f16e9d4722fd15f22d88d4d30ba92a.pdf","download_url":"https://www.academia.edu/attachments/66816004/download_file?st=MTczMzA3OTIyOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"The_Epidemiology_of_Chronic_Suppurative.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/66816004/a30011f16e9d4722fd15f22d88d4d30ba92a-libre.pdf?1620091721=\u0026response-content-disposition=attachment%3B+filename%3DThe_Epidemiology_of_Chronic_Suppurative.pdf\u0026Expires=1733082828\u0026Signature=VS3bCULg8pDob6dxOAfum0Pb94A62pH2XyeCVobicUvzslbW8CBSznxWcFoQSSc5Aw475UCsLKwP7pUI2zneQPf4XwZFIEzlPs0RnLQrJ5GuaYOR55DznXVdO~eqPO3NzMOOjzBxcxUW5BQebwo0uKhts4q5Tt6q9-A7gN~MDjrOPxCrJLt5Xj7bQpt5OW7rgGUxhVUVqQM0dl-OtruogDW6k4tUJc06x7-J-qpN~4EJNRpDi2dBqloTdov5PVAhS7Cnc1XgumzW-nksTd6IHLA1D82f3NII1Yyo2f2O66ltrKMi9a6Nxl0~s8U3RxPQIzf3UmVg9Zl6SoeK4NvrBw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="47950079"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/47950079/Vitamin_D_insufficiency_among_hospitalised_children_in_the_Northern_Territory"><img alt="Research paper thumbnail of Vitamin D insufficiency among hospitalised children in the Northern Territory" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/47950079/Vitamin_D_insufficiency_among_hospitalised_children_in_the_Northern_Territory">Vitamin D insufficiency among hospitalised children in the Northern Territory</a></div><div class="wp-workCard_item"><span>Journal of Paediatrics and Child Health</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Acute lower respiratory infections (ALRIs) are the most common reason for hospitalisation of youn...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Acute lower respiratory infections (ALRIs) are the most common reason for hospitalisation of young children in the Northern Territory of Australia. International studies have linked vitamin D deficiency with increased risk of ALRI in paediatric populations, but this has not been explored in tropical regions such as the Top End of the Northern Territory. The aim of this study is to determine the prevalence of vitamin D insufficiency among children hospitalised with ALRI in the Northern Territory. Vitamin D serum metabolite (25OHD3) levels were retrospectively measured using liquid chromatography-mass spectrometry in 74 children (64% male; 57% Indigenous) aged less than 3 years admitted to Royal Darwin Hospital in the Northern Territory of Australia between May 2008 and May 2010. There were 44 (59%) ALRI-classified hospitalisations and 30 (41%) non-ALRI-classified hospitalisations. The most common ALRI diagnoses were bronchiolitis (n = 22, 30%) and pneumonia (n = 21, 28%), whereas the most common non-ALRI diagnosis was gastroenteritis (n = 20, 27%). Overall, 24/74 (32%) children had 25OHD3 levels &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;75 nmol/L (insufficiency). For children hospitalised with ALRI, 23% (10/44) had vitamin D insufficiency compared with 47% (14/30) among children hospitalised for other reasons (odds ratio 0.34, 95% confidence interval 0.11-1.03; P = 0.043). Twelve of the 20 (60%) children hospitalised for gastroenteritis had vitamin D insufficiency. Vitamin D insufficiency was observed in almost one-third of these hospitalised children. Children hospitalised with an ALRI were less likely to have vitamin D insufficiency compared with children hospitalised for other conditions (predominantly gastroenteritis).</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="47950079"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="47950079"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 47950079; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=47950079]").text(description); $(".js-view-count[data-work-id=47950079]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 47950079; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='47950079']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 47950079, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=47950079]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":47950079,"title":"Vitamin D insufficiency among hospitalised children in the Northern Territory","translated_title":"","metadata":{"abstract":"Acute lower respiratory infections (ALRIs) are the most common reason for hospitalisation of young children in the Northern Territory of Australia. International studies have linked vitamin D deficiency with increased risk of ALRI in paediatric populations, but this has not been explored in tropical regions such as the Top End of the Northern Territory. The aim of this study is to determine the prevalence of vitamin D insufficiency among children hospitalised with ALRI in the Northern Territory. Vitamin D serum metabolite (25OHD3) levels were retrospectively measured using liquid chromatography-mass spectrometry in 74 children (64% male; 57% Indigenous) aged less than 3 years admitted to Royal Darwin Hospital in the Northern Territory of Australia between May 2008 and May 2010. There were 44 (59%) ALRI-classified hospitalisations and 30 (41%) non-ALRI-classified hospitalisations. The most common ALRI diagnoses were bronchiolitis (n = 22, 30%) and pneumonia (n = 21, 28%), whereas the most common non-ALRI diagnosis was gastroenteritis (n = 20, 27%). Overall, 24/74 (32%) children had 25OHD3 levels \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;75 nmol/L (insufficiency). For children hospitalised with ALRI, 23% (10/44) had vitamin D insufficiency compared with 47% (14/30) among children hospitalised for other reasons (odds ratio 0.34, 95% confidence interval 0.11-1.03; P = 0.043). Twelve of the 20 (60%) children hospitalised for gastroenteritis had vitamin D insufficiency. Vitamin D insufficiency was observed in almost one-third of these hospitalised children. Children hospitalised with an ALRI were less likely to have vitamin D insufficiency compared with children hospitalised for other conditions (predominantly gastroenteritis).","publisher":"Wiley-Blackwell","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Journal of Paediatrics and Child Health"},"translated_abstract":"Acute lower respiratory infections (ALRIs) are the most common reason for hospitalisation of young children in the Northern Territory of Australia. International studies have linked vitamin D deficiency with increased risk of ALRI in paediatric populations, but this has not been explored in tropical regions such as the Top End of the Northern Territory. The aim of this study is to determine the prevalence of vitamin D insufficiency among children hospitalised with ALRI in the Northern Territory. Vitamin D serum metabolite (25OHD3) levels were retrospectively measured using liquid chromatography-mass spectrometry in 74 children (64% male; 57% Indigenous) aged less than 3 years admitted to Royal Darwin Hospital in the Northern Territory of Australia between May 2008 and May 2010. There were 44 (59%) ALRI-classified hospitalisations and 30 (41%) non-ALRI-classified hospitalisations. The most common ALRI diagnoses were bronchiolitis (n = 22, 30%) and pneumonia (n = 21, 28%), whereas the most common non-ALRI diagnosis was gastroenteritis (n = 20, 27%). Overall, 24/74 (32%) children had 25OHD3 levels \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;75 nmol/L (insufficiency). For children hospitalised with ALRI, 23% (10/44) had vitamin D insufficiency compared with 47% (14/30) among children hospitalised for other reasons (odds ratio 0.34, 95% confidence interval 0.11-1.03; P = 0.043). Twelve of the 20 (60%) children hospitalised for gastroenteritis had vitamin D insufficiency. Vitamin D insufficiency was observed in almost one-third of these hospitalised children. Children hospitalised with an ALRI were less likely to have vitamin D insufficiency compared with children hospitalised for other conditions (predominantly gastroenteritis).","internal_url":"https://www.academia.edu/47950079/Vitamin_D_insufficiency_among_hospitalised_children_in_the_Northern_Territory","translated_internal_url":"","created_at":"2021-05-03T17:47:14.311-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":147569031,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Vitamin_D_insufficiency_among_hospitalised_children_in_the_Northern_Territory","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":147569031,"first_name":"Michael","middle_initials":null,"last_name":"Binks","page_name":"MichaelBinks","domain_name":"independent","created_at":"2020-02-27T19:41:19.082-08:00","display_name":"Michael Binks","url":"https://independent.academia.edu/MichaelBinks"},"attachments":[],"research_interests":[{"id":5769,"name":"Mass Spectrometry","url":"https://www.academia.edu/Documents/in/Mass_Spectrometry"},{"id":9531,"name":"Vitamin D","url":"https://www.academia.edu/Documents/in/Vitamin_D"},{"id":96213,"name":"Hospitalization","url":"https://www.academia.edu/Documents/in/Hospitalization"},{"id":111112,"name":"Pneumonia","url":"https://www.academia.edu/Documents/in/Pneumonia"},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors"},{"id":221386,"name":"Northern Territory","url":"https://www.academia.edu/Documents/in/Northern_Territory"},{"id":289330,"name":"Prevalence","url":"https://www.academia.edu/Documents/in/Prevalence"},{"id":437772,"name":"Odds ratio","url":"https://www.academia.edu/Documents/in/Odds_ratio"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies"},{"id":529631,"name":"Bronchiolitis","url":"https://www.academia.edu/Documents/in/Bronchiolitis"},{"id":568482,"name":"Biological markers","url":"https://www.academia.edu/Documents/in/Biological_markers"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1"},{"id":1034181,"name":"Cross Sectional Studies","url":"https://www.academia.edu/Documents/in/Cross_Sectional_Studies"},{"id":2471455,"name":"Acute Disease","url":"https://www.academia.edu/Documents/in/Acute_Disease"},{"id":2489700,"name":"Child preschool","url":"https://www.academia.edu/Documents/in/Child_preschool"},{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="47950078"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/47950078/Potential_use_of_Quantitative_Real_Time_PCR_for_pneumonia_diagnostics_in_a_high_carriage_population"><img alt="Research paper thumbnail of Potential use of Quantitative Real-Time PCR for pneumonia diagnostics in a high carriage population" class="work-thumbnail" src="https://attachments.academia-assets.com/66816003/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/47950078/Potential_use_of_Quantitative_Real_Time_PCR_for_pneumonia_diagnostics_in_a_high_carriage_population">Potential use of Quantitative Real-Time PCR for pneumonia diagnostics in a high carriage population</a></div><div class="wp-workCard_item"><span>pneumonia: A Peer Reviewed Open Access Journal</span><span>, 2012</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b9e22b9df554c2c68bb99ca1f2eeeb6e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":66816003,"asset_id":47950078,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/66816003/download_file?st=MTczMzA3OTIyOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="47950078"><a class="js-profile-work-strip-edit-button" 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$('.js-work-strip[data-work-id=47950078]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":47950078,"title":"Potential use of Quantitative Real-Time PCR for pneumonia diagnostics in a high carriage population","translated_title":"","metadata":{"publisher":"Springer Nature","grobid_abstract":"Ă DĞŶǌŝĞƐ ^ĐŚŽŽů ŽĨ ,ĞĂůƚŚ ZĞƐĞĂƌĐŚ͕ ŚĂƌůĞƐ ĂƌǁŝŶ hŶŝ|ĞƌƐŝƚǇ͕ EŽƌƚŚĞƌŶ dĞƌƌŝƚŽƌǇ͕ ƵƐƚƌĂůŝĂ ΎŽƌƌĞƐƉŽŶĚŝŶŐ ĂƵƚŚŽƌ͗ :ĂŶĂ \u003eĂŝ͕ ŚŝůĚ ,ĞĂůƚŚ ŝ|ŝƐŝŽŶ͕ DĞŶǌŝĞƐ ^ĐŚŽŽů ŽĨ ,ĞĂůƚŚ ZĞƐĞĂƌĐŚ͕ ƵŝůĚŝŶŐ ϱϴ͕ ZŽǇĂů ĂƌǁŝŶ ,ŽƐƉŝƚĂů͕ ĂƌǁŝŶ ϬϴϭϬ͕ ƵƐƚƌĂůŝĂ͘ dĞůĞƉŚŽŶĞ͗ нϲϭ ;ϬͿϴ ϴϵϮϮ ϳϵϭϳ͘ ŵĂŝů͗ ũĂŶĂ͘ůĂŝΛŵĞŶǌŝĞƐ͘ĞĚƵ͘ĂƵ ƵƚŚŽƌ ĐŽŶƚƌŝďƵƟŽŶƐ͗ ĂĐŚ ĂƵƚŚŽƌ ŵĂĚĞ ĂŶ ĞƋƵĂů ĐŽŶƚƌŝďƵƟŽŶ ƚŽ ƚŚĞ ƐƚƵĚǇ Abstract DŽůĞĐƵůĂƌ ŵĞƚŚŽĚƐ ŽīĞƌ ŝŵƉƌŽ|ĞŵĞŶƚ ŝŶ ƚŚĞ ĚĞƚĞĐƟŽŶ ŽĨ ĐĂƵƐĂƟ|Ğ ƉŶĞƵŵŽŶŝĂ ƉĂƚŚŽŐĞŶƐ͕ ďƵƚ ƚŚĞƌĞ ĂƌĞ ĐŽŶĐĞƌŶƐ ŽĨ ĨĂůƐĞ ƉŽƐŝƟ|Ğ ƌĞƐƵůƚƐ͘ ,ĞƌĞ ǁĞ |ĂůŝĚĂƚĞ ƋƵĂŶƟƚĂƟ|Ğ ƌĞĂůͲƟŵĞ WZ ;ƋWZͿ ĂƐƐĂǇƐ ĨŽƌ ƚŚĞ ĚĞƚĞĐƟŽŶ ŽĨ Streptococcus pneumoniae ĂŶĚ ,ĂĞŵŽƉŚŝůƵƐ ŝŶŇƵĞŶǌĂĞ ŝŶ͗ ;ĂͿ ƐƉŝŬĞĚ ƐĞƌƵŵ ƐĂŵƉůĞƐ ĂŶĚ ;ďͿ ŝŶ ŵĂƚĐŚĞĚ ƐĞƌƵŵ ĂŶĚ ŶĂƐŽƉŚĂƌǇŶŐĞĂů ƐǁĂďƐ ĨƌŽŵ Ă ƉŽƉƵůĂƟŽŶ ŽĨ /ŶĚŝŐĞŶŽƵƐ ƵƐƚƌĂůŝĂŶ ĐŚŝůĚƌĞŶ ǁŝƚŚŽƵƚ ƉŶĞƵŵŽŶŝĂ͕ ďƵƚ ǁŝƚŚ Ă ŚŝŐŚ ŶĂƐŽƉŚĂƌǇŶŐĞĂů ĐĂƌͲ ƌŝĂŐĞ ƉƌĞ|ĂůĞŶĐĞ ŽĨ S. pneumoniae ĂŶĚ ,͘ ŝŶŇƵĞŶǌĂĞ͘ DĂƚĐŚĞĚ ƐĞƌĂ ĂŶĚ ŶĂƐŽƉŚĂƌǇŶŐĞĂů ƐǁĂďƐ ǁĞƌĞ ƐĞůĞĐƚĞĚ ĨƌŽŵ /ŶĚŝŐĞŶŽƵƐ ĐŚŝůĚƌĞŶ ůĞƐƐ ƚŚĂŶ ϱ ǇĞĂƌƐ ŽĨ ĂŐĞ ǁŝƚŚŽƵƚ Ă ĚŝĂŐŶŽƐŝƐ ŽĨ ƉŶĞƵŵŽŶŝĂ͘ ^ƉĞĐŝŵĞŶƐ ǁĞƌĞ ĂƐƐĂǇĞĚ ďǇ ƋWZ ƚĂƌŐĞƟŶŐ ƚŚĞ lytA ĂŶĚ glpQ ŐĞŶĞƐ ĨƌŽŵ S. pneumoniae ĂŶĚ ,͘ ŝŶŇƵĞŶǌĂĞ͕ ƌĞƐƉĞĐƟ|ĞůǇ͘ hƐŝŶŐ ƋWZ͕ ŶĞŝƚŚĞƌ S. pneumoniae nor ,͘ ŝŶŇƵĞŶǌĂĞ E ǁĂƐ ĚĞƚĞĐƚĞĚ ŝŶ ƐĞƌƵŵ ƐĂŵƉůĞƐ͕ Ğ|ĞŶ ĂŌĞƌ ĐŽŶĐĞŶƚƌĂƟŽŶ ŽĨ ƐĞƌƵŵ E ͘ /Ŷ ŵĂƚĐŚĞĚ ŶĂƐŽƉŚĂƌǇŶŐĞĂů ƐǁĂďƐ͕ ďĂĐƚĞƌŝĂů ůŽĂĚ ǁĂƐ ŚŝŐŚ ǁŝƚŚ ƵƉ ƚŽ ϭϬ ϲ ĐĞůůƐͬŵů ĚĞƚĞĐƚĞĚ ďǇ ƋWZ͘ /Ŷ ƚŚŝƐ ĐŽŚŽƌƚ ŽĨ ĐŚŝůĚƌĞŶ ǁŝƚŚ Ă ŚŝŐŚ ŶĂƐŽƉŚĂƌǇŶŐĞĂů ĐĂƌƌŝĂŐĞ͕ ƉƌĞ|ĂůĞŶĐĞ ĂŶĚ ďĂĐƚĞƌŝĂů ůŽĂĚ ŽĨ ƉŶĞƵŵŽŶŝĂ ƉĂƚŚŽŐĞŶƐ͕ ƋWZ ŽŶ ƐĞƌĂ ǁŽƵůĚ ŶŽƚ ŚĂ|Ğ ƉƌŽĚƵĐĞĚ Ă ĨĂůƐĞ ƉŶĞƵŵŽŶŝĂ ĚŝĂŐŶŽƐŝƐ͘ dŚƵƐ͕ ƋWZ ĂŶĂůǇƐŝƐ ŽĨ ƐĞƌĂ ĂƉƉĞĂƌƐ ƚŽ ďĞ ĂŶ ĂƉƉƌŽƉƌŝĂƚĞ ŵĞƚŚŽĚ ƚŽ ĂŝĚ ĂĞƟŽůŽŐŝĐĂů ĚŝĂŐŶŽƐŝƐ ŽĨ ƉŶĞƵŵŽŶŝĂ ŝŶ ƚŚŝƐ 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href="https://www.academia.edu/47950077/Expression_of_two_novel_proteins_in_Chlamydia_trachomatis_during_natural_infection">Expression of two novel proteins in Chlamydia trachomatis during natural infection</a></div><div class="wp-workCard_item"><span>Microbial Pathogenesis</span><span>, 2000</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">... Garry SA Myers f2 , Richard Grinvalds , Susanne Booth f3 , Susan I. Hutton , Michael Binks , ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">... Garry SA Myers f2 , Richard Grinvalds , Susanne Booth f3 , Susan I. Hutton , Michael Binks , David J. Kemp and Kadaba S. Sriprakash f1. ... 3. CC Kuo, JT Grayston, LA Campbell, YA Goo, RW Wissler and EP Benditt, Chlamydia pneumoniae (TWAR) in coronary arteries of young ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="47950077"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="47950077"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 47950077; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=47950077]").text(description); $(".js-view-count[data-work-id=47950077]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 47950077; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='47950077']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 47950077, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=47950077]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":47950077,"title":"Expression of two novel proteins in Chlamydia trachomatis during natural infection","translated_title":"","metadata":{"abstract":"... Garry SA Myers f2 , Richard Grinvalds , Susanne Booth f3 , Susan I. Hutton , Michael Binks , David J. Kemp and Kadaba S. Sriprakash f1. ... 3. CC Kuo, JT Grayston, LA Campbell, YA Goo, RW Wissler and EP Benditt, Chlamydia pneumoniae (TWAR) in coronary arteries of young ...","publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":2000,"errors":{}},"publication_name":"Microbial Pathogenesis"},"translated_abstract":"... Garry SA Myers f2 , Richard Grinvalds , Susanne Booth f3 , Susan I. Hutton , Michael Binks , David J. Kemp and Kadaba S. Sriprakash f1. ... 3. CC Kuo, JT Grayston, LA Campbell, YA Goo, RW Wissler and EP Benditt, Chlamydia pneumoniae (TWAR) in coronary arteries of young ...","internal_url":"https://www.academia.edu/47950077/Expression_of_two_novel_proteins_in_Chlamydia_trachomatis_during_natural_infection","translated_internal_url":"","created_at":"2021-05-03T17:47:14.160-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":147569031,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Expression_of_two_novel_proteins_in_Chlamydia_trachomatis_during_natural_infection","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":147569031,"first_name":"Michael","middle_initials":null,"last_name":"Binks","page_name":"MichaelBinks","domain_name":"independent","created_at":"2020-02-27T19:41:19.082-08:00","display_name":"Michael Binks","url":"https://independent.academia.edu/MichaelBinks"},"attachments":[],"research_interests":[{"id":159,"name":"Microbiology","url":"https://www.academia.edu/Documents/in/Microbiology"},{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology"},{"id":6947,"name":"Medical Microbiology","url":"https://www.academia.edu/Documents/in/Medical_Microbiology"},{"id":11298,"name":"Membrane Proteins","url":"https://www.academia.edu/Documents/in/Membrane_Proteins"},{"id":34106,"name":"Chlamydia trachomatis","url":"https://www.academia.edu/Documents/in/Chlamydia_trachomatis"},{"id":159742,"name":"Microbial","url":"https://www.academia.edu/Documents/in/Microbial"},{"id":175430,"name":"Microbial Pathogenesis","url":"https://www.academia.edu/Documents/in/Microbial_Pathogenesis"},{"id":462111,"name":"Western blot","url":"https://www.academia.edu/Documents/in/Western_blot"},{"id":585573,"name":"Amino Acid Profile","url":"https://www.academia.edu/Documents/in/Amino_Acid_Profile"},{"id":900881,"name":"Membrane Protein","url":"https://www.academia.edu/Documents/in/Membrane_Protein"},{"id":999803,"name":"Gene Family","url":"https://www.academia.edu/Documents/in/Gene_Family"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="47950076"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/47950076/Streptococcal_DRS_distantly_related_to_SIC_and_SIC_inhibit_antimicrobial_peptides_components_of_mucosal_innate_immunity_a_comparison_of_their_activities"><img alt="Research paper thumbnail of Streptococcal DRS (distantly related to SIC) and SIC inhibit antimicrobial peptides, components of mucosal innate immunity: a comparison of their activities" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/47950076/Streptococcal_DRS_distantly_related_to_SIC_and_SIC_inhibit_antimicrobial_peptides_components_of_mucosal_innate_immunity_a_comparison_of_their_activities">Streptococcal DRS (distantly related to SIC) and SIC inhibit antimicrobial peptides, components of mucosal innate immunity: a comparison of their activities</a></div><div class="wp-workCard_item"><span>Microbes and Infection</span><span>, 2007</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">&amp;amp;amp;quot;Streptococcal inhibitor of complement&amp;amp;amp;quot; (SIC) and &amp;amp;amp;...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">&amp;amp;amp;quot;Streptococcal inhibitor of complement&amp;amp;amp;quot; (SIC) and &amp;amp;amp;quot;distantly related to SIC&amp;amp;amp;quot; (DRS) are related virulence factors secreted by M1 and M12 strains of GAS, respectively. The human mucosal innate immune system, important components of which are beta-defensins, secretory leukocyte proteinase inhibitor (SLPI) and lysozyme, provides the first line of defence against microorganisms. We report the interaction between DRS and these proteins; further investigations into the interaction of SIC with the beta-defensins; and compare the sensitivity of M12 and M1 GAS to SLPI. We show that SLPI, which kills M1 GAS and is inhibited by SIC, cannot kill M12 GAS. DRS cannot inhibit SLPI killing of M1 GAS, although ELISA shows binding of DRS to SLPI. We suggest that the target for SLPI on M1 GAS resembles SIC, and soluble SIC inhibits by acting as a decoy for SLPI. M12 GAS may not have this target and cannot interact with SLPI. DRS inhibits the antibacterial action of hBD-2 and hBD-3. Binding of both SIC and DRS to hBD-2, and DRS to hBD-3, shows small positive enthalpy, suggesting that binding is largely hydrophobic. The data for SIC and hBD-3 indicate that this is not a homogeneous bimolecular interaction. We conclude that DRS shares several of the properties of SIC, and therefore can be considered an important virulence factor of M12 GAS and an aid to colonization of the host mucosae.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="47950076"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="47950076"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 47950076; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=47950076]").text(description); $(".js-view-count[data-work-id=47950076]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 47950076; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='47950076']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 47950076, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=47950076]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":47950076,"title":"Streptococcal DRS (distantly related to SIC) and SIC inhibit antimicrobial peptides, components of mucosal innate immunity: a comparison of their activities","translated_title":"","metadata":{"abstract":"\u0026amp;amp;amp;quot;Streptococcal inhibitor of complement\u0026amp;amp;amp;quot; (SIC) and \u0026amp;amp;amp;quot;distantly related to SIC\u0026amp;amp;amp;quot; (DRS) are related virulence factors secreted by M1 and M12 strains of GAS, respectively. The human mucosal innate immune system, important components of which are beta-defensins, secretory leukocyte proteinase inhibitor (SLPI) and lysozyme, provides the first line of defence against microorganisms. We report the interaction between DRS and these proteins; further investigations into the interaction of SIC with the beta-defensins; and compare the sensitivity of M12 and M1 GAS to SLPI. We show that SLPI, which kills M1 GAS and is inhibited by SIC, cannot kill M12 GAS. DRS cannot inhibit SLPI killing of M1 GAS, although ELISA shows binding of DRS to SLPI. We suggest that the target for SLPI on M1 GAS resembles SIC, and soluble SIC inhibits by acting as a decoy for SLPI. M12 GAS may not have this target and cannot interact with SLPI. DRS inhibits the antibacterial action of hBD-2 and hBD-3. Binding of both SIC and DRS to hBD-2, and DRS to hBD-3, shows small positive enthalpy, suggesting that binding is largely hydrophobic. The data for SIC and hBD-3 indicate that this is not a homogeneous bimolecular interaction. We conclude that DRS shares several of the properties of SIC, and therefore can be considered an important virulence factor of M12 GAS and an aid to colonization of the host mucosae.","publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":2007,"errors":{}},"publication_name":"Microbes and Infection"},"translated_abstract":"\u0026amp;amp;amp;quot;Streptococcal inhibitor of complement\u0026amp;amp;amp;quot; (SIC) and \u0026amp;amp;amp;quot;distantly related to SIC\u0026amp;amp;amp;quot; (DRS) are related virulence factors secreted by M1 and M12 strains of GAS, respectively. The human mucosal innate immune system, important components of which are beta-defensins, secretory leukocyte proteinase inhibitor (SLPI) and lysozyme, provides the first line of defence against microorganisms. We report the interaction between DRS and these proteins; further investigations into the interaction of SIC with the beta-defensins; and compare the sensitivity of M12 and M1 GAS to SLPI. We show that SLPI, which kills M1 GAS and is inhibited by SIC, cannot kill M12 GAS. DRS cannot inhibit SLPI killing of M1 GAS, although ELISA shows binding of DRS to SLPI. We suggest that the target for SLPI on M1 GAS resembles SIC, and soluble SIC inhibits by acting as a decoy for SLPI. M12 GAS may not have this target and cannot interact with SLPI. DRS inhibits the antibacterial action of hBD-2 and hBD-3. Binding of both SIC and DRS to hBD-2, and DRS to hBD-3, shows small positive enthalpy, suggesting that binding is largely hydrophobic. The data for SIC and hBD-3 indicate that this is not a homogeneous bimolecular interaction. We conclude that DRS shares several of the properties of SIC, and therefore can be considered an important virulence factor of M12 GAS and an aid to colonization of the host mucosae.","internal_url":"https://www.academia.edu/47950076/Streptococcal_DRS_distantly_related_to_SIC_and_SIC_inhibit_antimicrobial_peptides_components_of_mucosal_innate_immunity_a_comparison_of_their_activities","translated_internal_url":"","created_at":"2021-05-03T17:47:14.087-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":147569031,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Streptococcal_DRS_distantly_related_to_SIC_and_SIC_inhibit_antimicrobial_peptides_components_of_mucosal_innate_immunity_a_comparison_of_their_activities","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":147569031,"first_name":"Michael","middle_initials":null,"last_name":"Binks","page_name":"MichaelBinks","domain_name":"independent","created_at":"2020-02-27T19:41:19.082-08:00","display_name":"Michael Binks","url":"https://independent.academia.edu/MichaelBinks"},"attachments":[],"research_interests":[{"id":159,"name":"Microbiology","url":"https://www.academia.edu/Documents/in/Microbiology"},{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology"},{"id":6947,"name":"Medical Microbiology","url":"https://www.academia.edu/Documents/in/Medical_Microbiology"},{"id":24706,"name":"Innate immunity","url":"https://www.academia.edu/Documents/in/Innate_immunity"},{"id":113903,"name":"Bacteria","url":"https://www.academia.edu/Documents/in/Bacteria"},{"id":139963,"name":"Streptococcus Pyogenes","url":"https://www.academia.edu/Documents/in/Streptococcus_Pyogenes"},{"id":220440,"name":"Antimicrobial Peptide","url":"https://www.academia.edu/Documents/in/Antimicrobial_Peptide"},{"id":587939,"name":"Virulence factor","url":"https://www.academia.edu/Documents/in/Virulence_factor"},{"id":588623,"name":"Complement","url":"https://www.academia.edu/Documents/in/Complement"},{"id":694109,"name":"Beta Defensins","url":"https://www.academia.edu/Documents/in/Beta_Defensins"},{"id":923659,"name":"Virulence Factors","url":"https://www.academia.edu/Documents/in/Virulence_Factors"},{"id":1272906,"name":"Enzyme Linked Immunosorbent Assay","url":"https://www.academia.edu/Documents/in/Enzyme_Linked_Immunosorbent_Assay"},{"id":1938317,"name":"Innate Immune System","url":"https://www.academia.edu/Documents/in/Innate_Immune_System"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="47950075"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/47950075/Molecular_surveillance_of_true_nontypeable_Haemophilus_influenzae_an_evaluation_of_PCR_screening_assays"><img alt="Research paper thumbnail of Molecular surveillance of true nontypeable Haemophilus influenzae: an evaluation of PCR screening assays" class="work-thumbnail" src="https://attachments.academia-assets.com/66816018/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/47950075/Molecular_surveillance_of_true_nontypeable_Haemophilus_influenzae_an_evaluation_of_PCR_screening_assays">Molecular surveillance of true nontypeable Haemophilus influenzae: an evaluation of PCR screening assays</a></div><div class="wp-workCard_item"><span>PloS one</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Unambiguous identification of nontypeable Haemophilus influenzae (NTHi) is not possible by conven...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Unambiguous identification of nontypeable Haemophilus influenzae (NTHi) is not possible by conventional microbiology. Molecular characterisation of phenotypically defined NTHi isolates suggests that up to 40% are Haemophilus haemolyticus (Hh); however, the genetic similarity of NTHi and Hh limits the power of simple molecular techniques such as PCR for species discrimination.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9fa7b4c365c4c30d1ed297f9eb041c89" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":66816018,"asset_id":47950075,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/66816018/download_file?st=MTczMzA3OTIyOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="47950075"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="47950075"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 47950075; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=47950075]").text(description); $(".js-view-count[data-work-id=47950075]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 47950075; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='47950075']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 47950075, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9fa7b4c365c4c30d1ed297f9eb041c89" } } $('.js-work-strip[data-work-id=47950075]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":47950075,"title":"Molecular surveillance of true nontypeable Haemophilus influenzae: an evaluation of PCR screening assays","translated_title":"","metadata":{"abstract":"Unambiguous identification of nontypeable Haemophilus influenzae (NTHi) is not possible by conventional microbiology. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="47950074"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/47950074/Whole_Genome_Characterization_and_Genotyping_of_Global_WU_Polyomavirus_Strains"><img alt="Research paper thumbnail of Whole-Genome Characterization and Genotyping of Global WU Polyomavirus Strains" class="work-thumbnail" src="https://attachments.academia-assets.com/66816019/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/47950074/Whole_Genome_Characterization_and_Genotyping_of_Global_WU_Polyomavirus_Strains">Whole-Genome Characterization and Genotyping of Global WU Polyomavirus Strains</a></div><div class="wp-workCard_item"><span>Journal of Virology</span><span>, 2010</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="833ee910983e1bffd6a87dd741a2de01" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":66816019,"asset_id":47950074,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/66816019/download_file?st=MTczMzA3OTIyOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="47950074"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="47950074"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 47950074; 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Using whole-genome sequencing of 48 WUV strains collected in four continents over a 5-year period and 16 publicly available whole-genome sequences, we identified three main WUV clades and five subtypes, provisionally termed Ia, Ib, Ic, II, IIIa, and IIIb. Overall nucleotide variation was low (0 to 1.2%). 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The purpose of this study was to characterize carriage isolates of NSP from Indigenous children vaccinated with the seven-valent pneumococcal conjugate vaccine (PCV7) and to use these data to guide decisions on reporting of NSP. A total of 182 NSP were characterized by BOX typing, antibiogram analysis, and multilocus sequence typing (MLST) of common BOX types. NSP positive for the wzg capsule gene were analyzed by a multiplex PCR-based reverse line blot hybridization assay (mPCR/RLB-H) targeting capsule genes to determine the serotype. Among 182 NSP, 49 BOX types were identified. MLST of 10 representative isolates found 7 STs, including ST448 (which accounted for 11% of NSP). Non-penicillin susceptibility was evident in 51% of the isolates. Pneumococcal wzg sequences were detected in only 23 (13%) NSP, including 10 that contained an ϳ1.2-kb insert in the region. mPCR/RLB-H identified serotype 14 wzy sequences in all 10 NSP, and 1 also contained a serotype 3-specific wze sequence. Among the remaining 13 wzg-positive NSP, few belonged to the serotypes represented in PCV7. It appears that most NSP identified in Australian Indigenous children are from a true nonencapsulated lineage. Few NSP represented serotypes in PCV7 that suppress capsular expression. High rates of carriage and penicillin resistance and the occasional presence of capsule genes suggest a role for NSP in the maintenance and survival of capsulated pneumococci. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="47950085"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/47950085/_Links2HealthierBubs_cohort_study_protocol_for_a_record_linkage_study_on_the_safety_uptake_and_effectiveness_of_influenza_and_pertussis_vaccines_among_pregnant_Australian_women"><img alt="Research paper thumbnail of ‘Links2HealthierBubs’ cohort study: protocol for a record linkage study on the safety, uptake and effectiveness of influenza and pertussis vaccines among pregnant Australian women" class="work-thumbnail" src="https://attachments.academia-assets.com/66816015/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/47950085/_Links2HealthierBubs_cohort_study_protocol_for_a_record_linkage_study_on_the_safety_uptake_and_effectiveness_of_influenza_and_pertussis_vaccines_among_pregnant_Australian_women">‘Links2HealthierBubs’ cohort study: protocol for a record linkage study on the safety, uptake and effectiveness of influenza and pertussis vaccines among pregnant Australian women</a></div><div class="wp-workCard_item"><span>BMJ Open</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">IntroductionPregnant women and infants are at risk of severe influenza and pertussis infection. I...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">IntroductionPregnant women and infants are at risk of severe influenza and pertussis infection. Inactivated influenza vaccine (IIV) and diphtheria-tetanus-acellular pertussis vaccine (dTpa) are recommended during pregnancy to protect both mothers and infants. In Australia, uptake is not routinely monitored but coverage appears sub-optimal. Evidence on the safety of combined antenatal IIV and dTpa is fragmented or deficient, and there remain knowledge gaps of population-level vaccine effectiveness. We aim to establish a large, population-based, multi-jurisdictional cohort of mother-infant pairs to measure the uptake, safety and effectiveness of antenatal IIV and dTpa vaccines in three Australian jurisdictions. This is a first step toward assessing the impact of antenatal vaccination programmes in Australia, which can then inform government policy with respect to future strategies in national vaccination programmes.Methods and analysis‘Links2HealthierBubs’ is an observational, populat...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7ea9f6394f9a49ea5ab522b58a8c4af1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":66816015,"asset_id":47950085,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/66816015/download_file?st=MTczMzA3OTIyOSw4LjIyMi4yMDguMTQ2&st=MTczMzA3OTIyOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="47950085"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="47950085"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 47950085; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=47950085]").text(description); $(".js-view-count[data-work-id=47950085]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 47950085; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='47950085']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 47950085, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7ea9f6394f9a49ea5ab522b58a8c4af1" } } $('.js-work-strip[data-work-id=47950085]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":47950085,"title":"‘Links2HealthierBubs’ cohort study: protocol for a record linkage study on the safety, uptake and effectiveness of influenza and pertussis vaccines among pregnant Australian women","translated_title":"","metadata":{"abstract":"IntroductionPregnant women and infants are at risk of severe influenza and pertussis infection. 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We aim to establish a large, population-based, multi-jurisdictional cohort of mother-infant pairs to measure the uptake, safety and effectiveness of antenatal IIV and dTpa vaccines in three Australian jurisdictions. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="47950084"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/47950084/Birth_outcomes_in_Aboriginal_mother_infant_pairs_from_the_Northern_Territory_Australia_who_received_23_valent_polysaccharide_pneumococcal_vaccination_during_pregnancy_2006_2011_The_PneuMum_randomised_controlled_trial"><img alt="Research paper thumbnail of Birth outcomes in Aboriginal mother–infant pairs from the Northern Territory, Australia, who received 23‐valent polysaccharide pneumococcal vaccination during pregnancy, 2006–2011: The PneuMum randomised controlled trial" class="work-thumbnail" src="https://attachments.academia-assets.com/66816017/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/47950084/Birth_outcomes_in_Aboriginal_mother_infant_pairs_from_the_Northern_Territory_Australia_who_received_23_valent_polysaccharide_pneumococcal_vaccination_during_pregnancy_2006_2011_The_PneuMum_randomised_controlled_trial">Birth outcomes in Aboriginal mother–infant pairs from the Northern Territory, Australia, who received 23‐valent polysaccharide pneumococcal vaccination during pregnancy, 2006–2011: The PneuMum randomised controlled trial</a></div><div class="wp-workCard_item"><span>Australian and New Zealand Journal of Obstetrics and Gynaecology</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="069717a4e05f3ca5cd7ee66ca4239082" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":66816017,"asset_id":47950084,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/66816017/download_file?st=MTczMzA3OTIyOSw4LjIyMi4yMDguMTQ2&st=MTczMzA3OTIyOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="47950084"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="47950084"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 47950084; 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Inactivated influenza vaccine (IIV) and pertussis vaccination are recommended in pregnancy. Limited safety data exist for women who received IIV vaccine during the first trimester of pregnancy or received both vaccines in pregnancy. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="47950082"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/47950082/Amoxicillin_clavulanate_versus_azithromycin_for_respiratory_exacerbations_in_children_with_bronchiectasis_BEST_2_a_multicentre_double_blind_non_inferiority_randomised_controlled_trial"><img alt="Research paper thumbnail of Amoxicillin-clavulanate versus azithromycin for respiratory exacerbations in children with bronchiectasis (BEST-2): a multicentre, double-blind, non-inferiority, randomised controlled trial" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/47950082/Amoxicillin_clavulanate_versus_azithromycin_for_respiratory_exacerbations_in_children_with_bronchiectasis_BEST_2_a_multicentre_double_blind_non_inferiority_randomised_controlled_trial">Amoxicillin-clavulanate versus azithromycin for respiratory exacerbations in children with bronchiectasis (BEST-2): a multicentre, double-blind, non-inferiority, randomised controlled trial</a></div><div class="wp-workCard_item"><span>Lancet (London, England)</span><span>, Oct 6, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Although amoxicillin-clavulanate is the recommended first-line empirical oral antibiotic treatmen...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Although amoxicillin-clavulanate is the recommended first-line empirical oral antibiotic treatment for non-severe exacerbations in children with bronchiectasis, azithromycin is also often prescribed for its convenient once-daily dosing. No randomised controlled trials involving acute exacerbations in children with bronchiectasis have been published to our knowledge. We hypothesised that azithromycin is non-inferior to amoxicillin-clavulanate for resolving exacerbations in children with bronchiectasis. We did this parallel-group, double-dummy, double-blind, non-inferiority randomised controlled trial in three Australian and one New Zealand hospital between April, 2012, and August, 2016. We enrolled children aged 1-19 years with radiographically proven bronchiectasis unrelated to cystic fibrosis. At the start of an exacerbation, children were randomly assigned to oral suspensions of either amoxicillin-clavulanate (22·5 mg/kg, twice daily) and placebo or azithromycin (5 mg/kg per day) ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="47950082"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="47950082"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 47950082; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=47950082]").text(description); $(".js-view-count[data-work-id=47950082]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 47950082; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='47950082']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 47950082, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=47950082]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":47950082,"title":"Amoxicillin-clavulanate versus azithromycin for respiratory exacerbations in children with bronchiectasis (BEST-2): a multicentre, double-blind, non-inferiority, randomised controlled trial","translated_title":"","metadata":{"abstract":"Although amoxicillin-clavulanate is the recommended first-line empirical oral antibiotic treatment for non-severe exacerbations in children with bronchiectasis, azithromycin is also often prescribed for its convenient once-daily dosing. No randomised controlled trials involving acute exacerbations in children with bronchiectasis have been published to our knowledge. We hypothesised that azithromycin is non-inferior to amoxicillin-clavulanate for resolving exacerbations in children with bronchiectasis. We did this parallel-group, double-dummy, double-blind, non-inferiority randomised controlled trial in three Australian and one New Zealand hospital between April, 2012, and August, 2016. We enrolled children aged 1-19 years with radiographically proven bronchiectasis unrelated to cystic fibrosis. At the start of an exacerbation, children were randomly assigned to oral suspensions of either amoxicillin-clavulanate (22·5 mg/kg, twice daily) and placebo or azithromycin (5 mg/kg per day) ...","publication_date":{"day":6,"month":10,"year":2018,"errors":{}},"publication_name":"Lancet (London, England)"},"translated_abstract":"Although amoxicillin-clavulanate is the recommended first-line empirical oral antibiotic treatment for non-severe exacerbations in children with bronchiectasis, azithromycin is also often prescribed for its convenient once-daily dosing. No randomised controlled trials involving acute exacerbations in children with bronchiectasis have been published to our knowledge. We hypothesised that azithromycin is non-inferior to amoxicillin-clavulanate for resolving exacerbations in children with bronchiectasis. We did this parallel-group, double-dummy, double-blind, non-inferiority randomised controlled trial in three Australian and one New Zealand hospital between April, 2012, and August, 2016. We enrolled children aged 1-19 years with radiographically proven bronchiectasis unrelated to cystic fibrosis. At the start of an exacerbation, children were randomly assigned to oral suspensions of either amoxicillin-clavulanate (22·5 mg/kg, twice daily) and placebo or azithromycin (5 mg/kg per day) ...","internal_url":"https://www.academia.edu/47950082/Amoxicillin_clavulanate_versus_azithromycin_for_respiratory_exacerbations_in_children_with_bronchiectasis_BEST_2_a_multicentre_double_blind_non_inferiority_randomised_controlled_trial","translated_internal_url":"","created_at":"2021-05-03T17:47:14.539-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":147569031,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Amoxicillin_clavulanate_versus_azithromycin_for_respiratory_exacerbations_in_children_with_bronchiectasis_BEST_2_a_multicentre_double_blind_non_inferiority_randomised_controlled_trial","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":147569031,"first_name":"Michael","middle_initials":null,"last_name":"Binks","page_name":"MichaelBinks","domain_name":"independent","created_at":"2020-02-27T19:41:19.082-08:00","display_name":"Michael Binks","url":"https://independent.academia.edu/MichaelBinks"},"attachments":[],"research_interests":[{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome"},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child"},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult"},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant"},{"id":335984,"name":"Anti-Bacterial Agents","url":"https://www.academia.edu/Documents/in/Anti-Bacterial_Agents"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors"},{"id":584615,"name":"Disease Progression","url":"https://www.academia.edu/Documents/in/Disease_Progression"},{"id":589804,"name":"Bronchiectasis","url":"https://www.academia.edu/Documents/in/Bronchiectasis"},{"id":856412,"name":"Azithromycin","url":"https://www.academia.edu/Documents/in/Azithromycin"},{"id":2489700,"name":"Child preschool","url":"https://www.academia.edu/Documents/in/Child_preschool"},{"id":3094070,"name":"The Lancet","url":"https://www.academia.edu/Documents/in/The_Lancet"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="47950081"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/47950081/Bacteria_and_viruses_in_the_nasopharynx_immediately_prior_to_onset_of_acute_lower_respiratory_infections_in_Indigenous_Australian_children"><img alt="Research paper thumbnail of Bacteria and viruses in the nasopharynx immediately prior to onset of acute lower respiratory infections in Indigenous Australian children" class="work-thumbnail" src="https://attachments.academia-assets.com/66816008/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/47950081/Bacteria_and_viruses_in_the_nasopharynx_immediately_prior_to_onset_of_acute_lower_respiratory_infections_in_Indigenous_Australian_children">Bacteria and viruses in the nasopharynx immediately prior to onset of acute lower respiratory infections in Indigenous Australian children</a></div><div class="wp-workCard_item"><span>European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology</span><span>, Jan 29, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Acute lower respiratory infection (ALRI) is a major cause of hospitalization for Indigenous child...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Acute lower respiratory infection (ALRI) is a major cause of hospitalization for Indigenous children in remote regions of Australia. The associated microbiology remains unclear. Our aim was to determine whether the microbes present in the nasopharynx before an ALRI were associated with its onset. A retrospective case-control/crossover study among Indigenous children aged up to 2 years. ALRI cases identified by medical note review were eligible where nasopharyngeal swabs were available: (1) 0-21 days before ALRI onset (case); (2) 90-180 days before ALRI onset (same child controls); and (3) from time and age-matched children without ALRI (different child controls). PCR assays determined the presence and/or load of selected respiratory pathogens. Among 104 children (182 recorded ALRI episodes), 120 case-same child control and 170 case-different child control swab pairs were identified. Human adenoviruses (HAdV) were more prevalent in cases compared to same child controls (18 vs 7%; OR ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1e2501397884c5424347ad4f6bb24f40" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":66816008,"asset_id":47950081,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/66816008/download_file?st=MTczMzA3OTIyOSw4LjIyMi4yMDguMTQ2&st=MTczMzA3OTIyOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="47950081"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="47950081"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 47950081; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=47950081]").text(description); $(".js-view-count[data-work-id=47950081]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 47950081; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='47950081']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 47950081, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1e2501397884c5424347ad4f6bb24f40" } } $('.js-work-strip[data-work-id=47950081]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":47950081,"title":"Bacteria and viruses in the nasopharynx immediately prior to onset of acute lower respiratory infections in Indigenous Australian children","translated_title":"","metadata":{"abstract":"Acute lower respiratory infection (ALRI) is a major cause of hospitalization for Indigenous children in remote regions of Australia. The associated microbiology remains unclear. Our aim was to determine whether the microbes present in the nasopharynx before an ALRI were associated with its onset. A retrospective case-control/crossover study among Indigenous children aged up to 2 years. ALRI cases identified by medical note review were eligible where nasopharyngeal swabs were available: (1) 0-21 days before ALRI onset (case); (2) 90-180 days before ALRI onset (same child controls); and (3) from time and age-matched children without ALRI (different child controls). PCR assays determined the presence and/or load of selected respiratory pathogens. Among 104 children (182 recorded ALRI episodes), 120 case-same child control and 170 case-different child control swab pairs were identified. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="47950080"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/47950080/The_Epidemiology_of_Chronic_Suppurative_Lung_Disease_and_Bronchiectasis_in_Children_and_Adolescents"><img alt="Research paper thumbnail of The Epidemiology of Chronic Suppurative Lung Disease and Bronchiectasis in Children and Adolescents" class="work-thumbnail" src="https://attachments.academia-assets.com/66816004/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/47950080/The_Epidemiology_of_Chronic_Suppurative_Lung_Disease_and_Bronchiectasis_in_Children_and_Adolescents">The Epidemiology of Chronic Suppurative Lung Disease and Bronchiectasis in Children and Adolescents</a></div><div class="wp-workCard_item"><span>Frontiers in pediatrics</span><span>, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In the modern era, the global burden of childhood chronic suppurative lung disease (CSLD) remains...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In the modern era, the global burden of childhood chronic suppurative lung disease (CSLD) remains poorly captured by the literature. What is clear, however, is that CSLD is essentially a disease of poverty. Disadvantaged children from indigenous and low- and middle-income populations had a substantially higher burden of CSLD, generally infectious in etiology and of a more severe nature, than children in high-income countries. A universal issue was the delay in diagnosis and the inconsistent reporting of clinical features. Importantly, infection-related CSLD is largely preventable. A considerable research and clinical effort is needed to identify modifiable risk factors and socioeconomic determinants of CSLD and provide robust evidence to guide optimal prevention and management strategies. The purpose of this review was to update the international literature on the epidemiology, etiology, and clinical features of pediatric CSLD.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="0e2f539638073209261290e23e079305" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":66816004,"asset_id":47950080,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/66816004/download_file?st=MTczMzA3OTIyOSw4LjIyMi4yMDguMTQ2&st=MTczMzA3OTIyOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="47950080"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="47950080"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 47950080; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=47950080]").text(description); $(".js-view-count[data-work-id=47950080]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 47950080; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='47950080']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 47950080, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "0e2f539638073209261290e23e079305" } } $('.js-work-strip[data-work-id=47950080]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":47950080,"title":"The Epidemiology of Chronic Suppurative Lung Disease and Bronchiectasis in Children and Adolescents","translated_title":"","metadata":{"abstract":"In the modern era, the global burden of childhood chronic suppurative lung disease (CSLD) remains poorly captured by the literature. What is clear, however, is that CSLD is essentially a disease of poverty. Disadvantaged children from indigenous and low- and middle-income populations had a substantially higher burden of CSLD, generally infectious in etiology and of a more severe nature, than children in high-income countries. A universal issue was the delay in diagnosis and the inconsistent reporting of clinical features. Importantly, infection-related CSLD is largely preventable. A considerable research and clinical effort is needed to identify modifiable risk factors and socioeconomic determinants of CSLD and provide robust evidence to guide optimal prevention and management strategies. The purpose of this review was to update the international literature on the epidemiology, etiology, and clinical features of pediatric CSLD.","publication_date":{"day":null,"month":null,"year":2017,"errors":{}},"publication_name":"Frontiers in pediatrics"},"translated_abstract":"In the modern era, the global burden of childhood chronic suppurative lung disease (CSLD) remains poorly captured by the literature. What is clear, however, is that CSLD is essentially a disease of poverty. Disadvantaged children from indigenous and low- and middle-income populations had a substantially higher burden of CSLD, generally infectious in etiology and of a more severe nature, than children in high-income countries. A universal issue was the delay in diagnosis and the inconsistent reporting of clinical features. Importantly, infection-related CSLD is largely preventable. A considerable research and clinical effort is needed to identify modifiable risk factors and socioeconomic determinants of CSLD and provide robust evidence to guide optimal prevention and management strategies. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="47950079"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/47950079/Vitamin_D_insufficiency_among_hospitalised_children_in_the_Northern_Territory"><img alt="Research paper thumbnail of Vitamin D insufficiency among hospitalised children in the Northern Territory" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/47950079/Vitamin_D_insufficiency_among_hospitalised_children_in_the_Northern_Territory">Vitamin D insufficiency among hospitalised children in the Northern Territory</a></div><div class="wp-workCard_item"><span>Journal of Paediatrics and Child Health</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Acute lower respiratory infections (ALRIs) are the most common reason for hospitalisation of youn...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Acute lower respiratory infections (ALRIs) are the most common reason for hospitalisation of young children in the Northern Territory of Australia. International studies have linked vitamin D deficiency with increased risk of ALRI in paediatric populations, but this has not been explored in tropical regions such as the Top End of the Northern Territory. The aim of this study is to determine the prevalence of vitamin D insufficiency among children hospitalised with ALRI in the Northern Territory. Vitamin D serum metabolite (25OHD3) levels were retrospectively measured using liquid chromatography-mass spectrometry in 74 children (64% male; 57% Indigenous) aged less than 3 years admitted to Royal Darwin Hospital in the Northern Territory of Australia between May 2008 and May 2010. There were 44 (59%) ALRI-classified hospitalisations and 30 (41%) non-ALRI-classified hospitalisations. The most common ALRI diagnoses were bronchiolitis (n = 22, 30%) and pneumonia (n = 21, 28%), whereas the most common non-ALRI diagnosis was gastroenteritis (n = 20, 27%). Overall, 24/74 (32%) children had 25OHD3 levels &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;75 nmol/L (insufficiency). For children hospitalised with ALRI, 23% (10/44) had vitamin D insufficiency compared with 47% (14/30) among children hospitalised for other reasons (odds ratio 0.34, 95% confidence interval 0.11-1.03; P = 0.043). Twelve of the 20 (60%) children hospitalised for gastroenteritis had vitamin D insufficiency. Vitamin D insufficiency was observed in almost one-third of these hospitalised children. Children hospitalised with an ALRI were less likely to have vitamin D insufficiency compared with children hospitalised for other conditions (predominantly gastroenteritis).</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="47950079"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="47950079"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 47950079; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=47950079]").text(description); $(".js-view-count[data-work-id=47950079]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 47950079; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='47950079']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 47950079, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=47950079]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":47950079,"title":"Vitamin D insufficiency among hospitalised children in the Northern Territory","translated_title":"","metadata":{"abstract":"Acute lower respiratory infections (ALRIs) are the most common reason for hospitalisation of young children in the Northern Territory of Australia. International studies have linked vitamin D deficiency with increased risk of ALRI in paediatric populations, but this has not been explored in tropical regions such as the Top End of the Northern Territory. The aim of this study is to determine the prevalence of vitamin D insufficiency among children hospitalised with ALRI in the Northern Territory. Vitamin D serum metabolite (25OHD3) levels were retrospectively measured using liquid chromatography-mass spectrometry in 74 children (64% male; 57% Indigenous) aged less than 3 years admitted to Royal Darwin Hospital in the Northern Territory of Australia between May 2008 and May 2010. There were 44 (59%) ALRI-classified hospitalisations and 30 (41%) non-ALRI-classified hospitalisations. The most common ALRI diagnoses were bronchiolitis (n = 22, 30%) and pneumonia (n = 21, 28%), whereas the most common non-ALRI diagnosis was gastroenteritis (n = 20, 27%). Overall, 24/74 (32%) children had 25OHD3 levels \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;75 nmol/L (insufficiency). For children hospitalised with ALRI, 23% (10/44) had vitamin D insufficiency compared with 47% (14/30) among children hospitalised for other reasons (odds ratio 0.34, 95% confidence interval 0.11-1.03; P = 0.043). Twelve of the 20 (60%) children hospitalised for gastroenteritis had vitamin D insufficiency. Vitamin D insufficiency was observed in almost one-third of these hospitalised children. Children hospitalised with an ALRI were less likely to have vitamin D insufficiency compared with children hospitalised for other conditions (predominantly gastroenteritis).","publisher":"Wiley-Blackwell","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Journal of Paediatrics and Child Health"},"translated_abstract":"Acute lower respiratory infections (ALRIs) are the most common reason for hospitalisation of young children in the Northern Territory of Australia. International studies have linked vitamin D deficiency with increased risk of ALRI in paediatric populations, but this has not been explored in tropical regions such as the Top End of the Northern Territory. The aim of this study is to determine the prevalence of vitamin D insufficiency among children hospitalised with ALRI in the Northern Territory. Vitamin D serum metabolite (25OHD3) levels were retrospectively measured using liquid chromatography-mass spectrometry in 74 children (64% male; 57% Indigenous) aged less than 3 years admitted to Royal Darwin Hospital in the Northern Territory of Australia between May 2008 and May 2010. There were 44 (59%) ALRI-classified hospitalisations and 30 (41%) non-ALRI-classified hospitalisations. The most common ALRI diagnoses were bronchiolitis (n = 22, 30%) and pneumonia (n = 21, 28%), whereas the most common non-ALRI diagnosis was gastroenteritis (n = 20, 27%). Overall, 24/74 (32%) children had 25OHD3 levels \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;75 nmol/L (insufficiency). For children hospitalised with ALRI, 23% (10/44) had vitamin D insufficiency compared with 47% (14/30) among children hospitalised for other reasons (odds ratio 0.34, 95% confidence interval 0.11-1.03; P = 0.043). Twelve of the 20 (60%) children hospitalised for gastroenteritis had vitamin D insufficiency. Vitamin D insufficiency was observed in almost one-third of these hospitalised children. Children hospitalised with an ALRI were less likely to have vitamin D insufficiency compared with children hospitalised for other conditions (predominantly gastroenteritis).","internal_url":"https://www.academia.edu/47950079/Vitamin_D_insufficiency_among_hospitalised_children_in_the_Northern_Territory","translated_internal_url":"","created_at":"2021-05-03T17:47:14.311-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":147569031,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Vitamin_D_insufficiency_among_hospitalised_children_in_the_Northern_Territory","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":147569031,"first_name":"Michael","middle_initials":null,"last_name":"Binks","page_name":"MichaelBinks","domain_name":"independent","created_at":"2020-02-27T19:41:19.082-08:00","display_name":"Michael 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"profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="47950078"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/47950078/Potential_use_of_Quantitative_Real_Time_PCR_for_pneumonia_diagnostics_in_a_high_carriage_population"><img alt="Research paper thumbnail of Potential use of Quantitative Real-Time PCR for pneumonia diagnostics in a high carriage population" class="work-thumbnail" src="https://attachments.academia-assets.com/66816003/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/47950078/Potential_use_of_Quantitative_Real_Time_PCR_for_pneumonia_diagnostics_in_a_high_carriage_population">Potential use of Quantitative Real-Time PCR for pneumonia diagnostics in a high carriage population</a></div><div class="wp-workCard_item"><span>pneumonia: A Peer Reviewed Open Access Journal</span><span>, 2012</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b9e22b9df554c2c68bb99ca1f2eeeb6e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":66816003,"asset_id":47950078,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/66816003/download_file?st=MTczMzA3OTIyOSw4LjIyMi4yMDguMTQ2&st=MTczMzA3OTIyOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="47950078"><a 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pneumoniae ĂŶĚ ,ĂĞŵŽƉŚŝůƵƐ ŝŶŇƵĞŶǌĂĞ ŝŶ͗ ;ĂͿ ƐƉŝŬĞĚ ƐĞƌƵŵ ƐĂŵƉůĞƐ ĂŶĚ ;ďͿ ŝŶ ŵĂƚĐŚĞĚ ƐĞƌƵŵ ĂŶĚ ŶĂƐŽƉŚĂƌǇŶŐĞĂů ƐǁĂďƐ ĨƌŽŵ Ă ƉŽƉƵůĂƟŽŶ ŽĨ /ŶĚŝŐĞŶŽƵƐ ƵƐƚƌĂůŝĂŶ ĐŚŝůĚƌĞŶ ǁŝƚŚŽƵƚ ƉŶĞƵŵŽŶŝĂ͕ ďƵƚ ǁŝƚŚ Ă ŚŝŐŚ ŶĂƐŽƉŚĂƌǇŶŐĞĂů ĐĂƌͲ ƌŝĂŐĞ ƉƌĞ|ĂůĞŶĐĞ ŽĨ S. pneumoniae ĂŶĚ ,͘ ŝŶŇƵĞŶǌĂĞ͘ DĂƚĐŚĞĚ ƐĞƌĂ ĂŶĚ ŶĂƐŽƉŚĂƌǇŶŐĞĂů ƐǁĂďƐ ǁĞƌĞ ƐĞůĞĐƚĞĚ ĨƌŽŵ /ŶĚŝŐĞŶŽƵƐ ĐŚŝůĚƌĞŶ ůĞƐƐ ƚŚĂŶ ϱ ǇĞĂƌƐ ŽĨ ĂŐĞ ǁŝƚŚŽƵƚ Ă ĚŝĂŐŶŽƐŝƐ ŽĨ ƉŶĞƵŵŽŶŝĂ͘ ^ƉĞĐŝŵĞŶƐ ǁĞƌĞ ĂƐƐĂǇĞĚ ďǇ ƋWZ ƚĂƌŐĞƟŶŐ ƚŚĞ lytA ĂŶĚ glpQ ŐĞŶĞƐ ĨƌŽŵ S. pneumoniae ĂŶĚ ,͘ ŝŶŇƵĞŶǌĂĞ͕ ƌĞƐƉĞĐƟ|ĞůǇ͘ hƐŝŶŐ ƋWZ͕ ŶĞŝƚŚĞƌ S. pneumoniae nor ,͘ ŝŶŇƵĞŶǌĂĞ E ǁĂƐ ĚĞƚĞĐƚĞĚ ŝŶ ƐĞƌƵŵ ƐĂŵƉůĞƐ͕ Ğ|ĞŶ ĂŌĞƌ ĐŽŶĐĞŶƚƌĂƟŽŶ ŽĨ ƐĞƌƵŵ E ͘ /Ŷ ŵĂƚĐŚĞĚ ŶĂƐŽƉŚĂƌǇŶŐĞĂů ƐǁĂďƐ͕ ďĂĐƚĞƌŝĂů ůŽĂĚ ǁĂƐ ŚŝŐŚ ǁŝƚŚ ƵƉ ƚŽ ϭϬ ϲ ĐĞůůƐͬŵů ĚĞƚĞĐƚĞĚ ďǇ ƋWZ͘ /Ŷ ƚŚŝƐ ĐŽŚŽƌƚ ŽĨ ĐŚŝůĚƌĞŶ ǁŝƚŚ Ă ŚŝŐŚ ŶĂƐŽƉŚĂƌǇŶŐĞĂů ĐĂƌƌŝĂŐĞ͕ ƉƌĞ|ĂůĞŶĐĞ ĂŶĚ ďĂĐƚĞƌŝĂů ůŽĂĚ ŽĨ ƉŶĞƵŵŽŶŝĂ ƉĂƚŚŽŐĞŶƐ͕ ƋWZ ŽŶ ƐĞƌĂ ǁŽƵůĚ ŶŽƚ ŚĂ|Ğ ƉƌŽĚƵĐĞĚ Ă ĨĂůƐĞ ƉŶĞƵŵŽŶŝĂ ĚŝĂŐŶŽƐŝƐ͘ dŚƵƐ͕ ƋWZ ĂŶĂůǇƐŝƐ ŽĨ ƐĞƌĂ ĂƉƉĞĂƌƐ ƚŽ ďĞ ĂŶ ĂƉƉƌŽƉƌŝĂƚĞ ŵĞƚŚŽĚ ƚŽ ĂŝĚ 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dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="47950077"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/47950077/Expression_of_two_novel_proteins_in_Chlamydia_trachomatis_during_natural_infection"><img alt="Research paper thumbnail of Expression of two novel proteins in Chlamydia trachomatis during natural infection" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/47950077/Expression_of_two_novel_proteins_in_Chlamydia_trachomatis_during_natural_infection">Expression of two novel proteins in Chlamydia trachomatis during natural infection</a></div><div class="wp-workCard_item"><span>Microbial Pathogenesis</span><span>, 2000</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">... Garry SA Myers f2 , Richard Grinvalds , Susanne Booth f3 , Susan I. Hutton , Michael Binks , ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">... Garry SA Myers f2 , Richard Grinvalds , Susanne Booth f3 , Susan I. Hutton , Michael Binks , David J. Kemp and Kadaba S. Sriprakash f1. ... 3. CC Kuo, JT Grayston, LA Campbell, YA Goo, RW Wissler and EP Benditt, Chlamydia pneumoniae (TWAR) in coronary arteries of young ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="47950077"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="47950077"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 47950077; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=47950077]").text(description); $(".js-view-count[data-work-id=47950077]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 47950077; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='47950077']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 47950077, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=47950077]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":47950077,"title":"Expression of two novel proteins in Chlamydia trachomatis during natural infection","translated_title":"","metadata":{"abstract":"... 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CC Kuo, JT Grayston, LA Campbell, YA Goo, RW Wissler and EP Benditt, Chlamydia pneumoniae (TWAR) in coronary arteries of young ...","internal_url":"https://www.academia.edu/47950077/Expression_of_two_novel_proteins_in_Chlamydia_trachomatis_during_natural_infection","translated_internal_url":"","created_at":"2021-05-03T17:47:14.160-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":147569031,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Expression_of_two_novel_proteins_in_Chlamydia_trachomatis_during_natural_infection","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":147569031,"first_name":"Michael","middle_initials":null,"last_name":"Binks","page_name":"MichaelBinks","domain_name":"independent","created_at":"2020-02-27T19:41:19.082-08:00","display_name":"Michael Binks","url":"https://independent.academia.edu/MichaelBinks"},"attachments":[],"research_interests":[{"id":159,"name":"Microbiology","url":"https://www.academia.edu/Documents/in/Microbiology"},{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology"},{"id":6947,"name":"Medical Microbiology","url":"https://www.academia.edu/Documents/in/Medical_Microbiology"},{"id":11298,"name":"Membrane Proteins","url":"https://www.academia.edu/Documents/in/Membrane_Proteins"},{"id":34106,"name":"Chlamydia trachomatis","url":"https://www.academia.edu/Documents/in/Chlamydia_trachomatis"},{"id":159742,"name":"Microbial","url":"https://www.academia.edu/Documents/in/Microbial"},{"id":175430,"name":"Microbial Pathogenesis","url":"https://www.academia.edu/Documents/in/Microbial_Pathogenesis"},{"id":462111,"name":"Western blot","url":"https://www.academia.edu/Documents/in/Western_blot"},{"id":585573,"name":"Amino Acid Profile","url":"https://www.academia.edu/Documents/in/Amino_Acid_Profile"},{"id":900881,"name":"Membrane Protein","url":"https://www.academia.edu/Documents/in/Membrane_Protein"},{"id":999803,"name":"Gene Family","url":"https://www.academia.edu/Documents/in/Gene_Family"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="47950076"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/47950076/Streptococcal_DRS_distantly_related_to_SIC_and_SIC_inhibit_antimicrobial_peptides_components_of_mucosal_innate_immunity_a_comparison_of_their_activities"><img alt="Research paper thumbnail of Streptococcal DRS (distantly related to SIC) and SIC inhibit antimicrobial peptides, components of mucosal innate immunity: a comparison of their activities" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/47950076/Streptococcal_DRS_distantly_related_to_SIC_and_SIC_inhibit_antimicrobial_peptides_components_of_mucosal_innate_immunity_a_comparison_of_their_activities">Streptococcal DRS (distantly related to SIC) and SIC inhibit antimicrobial peptides, components of mucosal innate immunity: a comparison of their activities</a></div><div class="wp-workCard_item"><span>Microbes and Infection</span><span>, 2007</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">&amp;amp;amp;quot;Streptococcal inhibitor of complement&amp;amp;amp;quot; (SIC) and &amp;amp;amp;...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">&amp;amp;amp;quot;Streptococcal inhibitor of complement&amp;amp;amp;quot; (SIC) and &amp;amp;amp;quot;distantly related to SIC&amp;amp;amp;quot; (DRS) are related virulence factors secreted by M1 and M12 strains of GAS, respectively. The human mucosal innate immune system, important components of which are beta-defensins, secretory leukocyte proteinase inhibitor (SLPI) and lysozyme, provides the first line of defence against microorganisms. We report the interaction between DRS and these proteins; further investigations into the interaction of SIC with the beta-defensins; and compare the sensitivity of M12 and M1 GAS to SLPI. We show that SLPI, which kills M1 GAS and is inhibited by SIC, cannot kill M12 GAS. DRS cannot inhibit SLPI killing of M1 GAS, although ELISA shows binding of DRS to SLPI. We suggest that the target for SLPI on M1 GAS resembles SIC, and soluble SIC inhibits by acting as a decoy for SLPI. M12 GAS may not have this target and cannot interact with SLPI. DRS inhibits the antibacterial action of hBD-2 and hBD-3. Binding of both SIC and DRS to hBD-2, and DRS to hBD-3, shows small positive enthalpy, suggesting that binding is largely hydrophobic. The data for SIC and hBD-3 indicate that this is not a homogeneous bimolecular interaction. We conclude that DRS shares several of the properties of SIC, and therefore can be considered an important virulence factor of M12 GAS and an aid to colonization of the host mucosae.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="47950076"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="47950076"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 47950076; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=47950076]").text(description); $(".js-view-count[data-work-id=47950076]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 47950076; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='47950076']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 47950076, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=47950076]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":47950076,"title":"Streptococcal DRS (distantly related to SIC) and SIC inhibit antimicrobial peptides, components of mucosal innate immunity: a comparison of their activities","translated_title":"","metadata":{"abstract":"\u0026amp;amp;amp;quot;Streptococcal inhibitor of complement\u0026amp;amp;amp;quot; (SIC) and \u0026amp;amp;amp;quot;distantly related to SIC\u0026amp;amp;amp;quot; (DRS) are related virulence factors secreted by M1 and M12 strains of GAS, respectively. The human mucosal innate immune system, important components of which are beta-defensins, secretory leukocyte proteinase inhibitor (SLPI) and lysozyme, provides the first line of defence against microorganisms. We report the interaction between DRS and these proteins; further investigations into the interaction of SIC with the beta-defensins; and compare the sensitivity of M12 and M1 GAS to SLPI. We show that SLPI, which kills M1 GAS and is inhibited by SIC, cannot kill M12 GAS. DRS cannot inhibit SLPI killing of M1 GAS, although ELISA shows binding of DRS to SLPI. We suggest that the target for SLPI on M1 GAS resembles SIC, and soluble SIC inhibits by acting as a decoy for SLPI. M12 GAS may not have this target and cannot interact with SLPI. DRS inhibits the antibacterial action of hBD-2 and hBD-3. Binding of both SIC and DRS to hBD-2, and DRS to hBD-3, shows small positive enthalpy, suggesting that binding is largely hydrophobic. The data for SIC and hBD-3 indicate that this is not a homogeneous bimolecular interaction. We conclude that DRS shares several of the properties of SIC, and therefore can be considered an important virulence factor of M12 GAS and an aid to colonization of the host mucosae.","publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":2007,"errors":{}},"publication_name":"Microbes and Infection"},"translated_abstract":"\u0026amp;amp;amp;quot;Streptococcal inhibitor of complement\u0026amp;amp;amp;quot; (SIC) and \u0026amp;amp;amp;quot;distantly related to SIC\u0026amp;amp;amp;quot; (DRS) are related virulence factors secreted by M1 and M12 strains of GAS, respectively. The human mucosal innate immune system, important components of which are beta-defensins, secretory leukocyte proteinase inhibitor (SLPI) and lysozyme, provides the first line of defence against microorganisms. We report the interaction between DRS and these proteins; further investigations into the interaction of SIC with the beta-defensins; and compare the sensitivity of M12 and M1 GAS to SLPI. We show that SLPI, which kills M1 GAS and is inhibited by SIC, cannot kill M12 GAS. DRS cannot inhibit SLPI killing of M1 GAS, although ELISA shows binding of DRS to SLPI. We suggest that the target for SLPI on M1 GAS resembles SIC, and soluble SIC inhibits by acting as a decoy for SLPI. M12 GAS may not have this target and cannot interact with SLPI. DRS inhibits the antibacterial action of hBD-2 and hBD-3. Binding of both SIC and DRS to hBD-2, and DRS to hBD-3, shows small positive enthalpy, suggesting that binding is largely hydrophobic. The data for SIC and hBD-3 indicate that this is not a homogeneous bimolecular interaction. We conclude that DRS shares several of the properties of SIC, and therefore can be considered an important virulence factor of M12 GAS and an aid to colonization of the host mucosae.","internal_url":"https://www.academia.edu/47950076/Streptococcal_DRS_distantly_related_to_SIC_and_SIC_inhibit_antimicrobial_peptides_components_of_mucosal_innate_immunity_a_comparison_of_their_activities","translated_internal_url":"","created_at":"2021-05-03T17:47:14.087-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":147569031,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Streptococcal_DRS_distantly_related_to_SIC_and_SIC_inhibit_antimicrobial_peptides_components_of_mucosal_innate_immunity_a_comparison_of_their_activities","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":147569031,"first_name":"Michael","middle_initials":null,"last_name":"Binks","page_name":"MichaelBinks","domain_name":"independent","created_at":"2020-02-27T19:41:19.082-08:00","display_name":"Michael Binks","url":"https://independent.academia.edu/MichaelBinks"},"attachments":[],"research_interests":[{"id":159,"name":"Microbiology","url":"https://www.academia.edu/Documents/in/Microbiology"},{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology"},{"id":6947,"name":"Medical Microbiology","url":"https://www.academia.edu/Documents/in/Medical_Microbiology"},{"id":24706,"name":"Innate immunity","url":"https://www.academia.edu/Documents/in/Innate_immunity"},{"id":113903,"name":"Bacteria","url":"https://www.academia.edu/Documents/in/Bacteria"},{"id":139963,"name":"Streptococcus Pyogenes","url":"https://www.academia.edu/Documents/in/Streptococcus_Pyogenes"},{"id":220440,"name":"Antimicrobial Peptide","url":"https://www.academia.edu/Documents/in/Antimicrobial_Peptide"},{"id":587939,"name":"Virulence factor","url":"https://www.academia.edu/Documents/in/Virulence_factor"},{"id":588623,"name":"Complement","url":"https://www.academia.edu/Documents/in/Complement"},{"id":694109,"name":"Beta Defensins","url":"https://www.academia.edu/Documents/in/Beta_Defensins"},{"id":923659,"name":"Virulence Factors","url":"https://www.academia.edu/Documents/in/Virulence_Factors"},{"id":1272906,"name":"Enzyme Linked Immunosorbent Assay","url":"https://www.academia.edu/Documents/in/Enzyme_Linked_Immunosorbent_Assay"},{"id":1938317,"name":"Innate Immune System","url":"https://www.academia.edu/Documents/in/Innate_Immune_System"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="47950075"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/47950075/Molecular_surveillance_of_true_nontypeable_Haemophilus_influenzae_an_evaluation_of_PCR_screening_assays"><img alt="Research paper thumbnail of Molecular surveillance of true nontypeable Haemophilus influenzae: an evaluation of PCR screening assays" class="work-thumbnail" src="https://attachments.academia-assets.com/66816018/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/47950075/Molecular_surveillance_of_true_nontypeable_Haemophilus_influenzae_an_evaluation_of_PCR_screening_assays">Molecular surveillance of true nontypeable Haemophilus influenzae: an evaluation of PCR screening assays</a></div><div class="wp-workCard_item"><span>PloS one</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Unambiguous identification of nontypeable Haemophilus influenzae (NTHi) is not possible by conven...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Unambiguous identification of nontypeable Haemophilus influenzae (NTHi) is not possible by conventional microbiology. Molecular characterisation of phenotypically defined NTHi isolates suggests that up to 40% are Haemophilus haemolyticus (Hh); however, the genetic similarity of NTHi and Hh limits the power of simple molecular techniques such as PCR for species discrimination.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9fa7b4c365c4c30d1ed297f9eb041c89" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":66816018,"asset_id":47950075,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/66816018/download_file?st=MTczMzA3OTIyOSw4LjIyMi4yMDguMTQ2&st=MTczMzA3OTIyOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="47950075"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="47950075"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 47950075; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=47950075]").text(description); $(".js-view-count[data-work-id=47950075]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 47950075; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='47950075']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 47950075, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9fa7b4c365c4c30d1ed297f9eb041c89" } } $('.js-work-strip[data-work-id=47950075]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":47950075,"title":"Molecular surveillance of true nontypeable Haemophilus influenzae: an evaluation of PCR screening assays","translated_title":"","metadata":{"abstract":"Unambiguous identification of nontypeable Haemophilus influenzae (NTHi) is not possible by conventional microbiology. Molecular characterisation of phenotypically defined NTHi isolates suggests that up to 40% are Haemophilus haemolyticus (Hh); however, the genetic similarity of NTHi and Hh limits the power of simple molecular techniques such as PCR for species discrimination.","publisher":"ncbi.nlm.nih.gov","publication_date":{"day":null,"month":null,"year":2012,"errors":{}},"publication_name":"PloS one"},"translated_abstract":"Unambiguous identification of nontypeable Haemophilus influenzae (NTHi) is not possible by conventional microbiology. Molecular characterisation of phenotypically defined NTHi isolates suggests that up to 40% are Haemophilus haemolyticus (Hh); however, the genetic similarity of NTHi and Hh limits the power of simple molecular techniques such as PCR for species discrimination.","internal_url":"https://www.academia.edu/47950075/Molecular_surveillance_of_true_nontypeable_Haemophilus_influenzae_an_evaluation_of_PCR_screening_assays","translated_internal_url":"","created_at":"2021-05-03T17:47:13.964-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":147569031,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":66816018,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/66816018/thumbnails/1.jpg","file_name":"Molecular_surveillance_of_true_nontypeab20210503-2906-1dttgpa.pdf","download_url":"https://www.academia.edu/attachments/66816018/download_file?st=MTczMzA3OTIyOSw4LjIyMi4yMDguMTQ2&st=MTczMzA3OTIyOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Molecular_surveillance_of_true_nontypeab.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/66816018/Molecular_surveillance_of_true_nontypeab20210503-2906-1dttgpa.pdf?1620089301=\u0026response-content-disposition=attachment%3B+filename%3DMolecular_surveillance_of_true_nontypeab.pdf\u0026Expires=1733082828\u0026Signature=GJhXxu~VoMVLOwjyeh4fDBEmEeoaKJzX1iafFNdzE~kFljnmVwuCWtGz9kAX0lKOZQDvXjijLLwTzA8ZxBoCyy5ior5f6UjsXJAAC8p5PLC~wm6VgMSb3hcFcqvHAFSvZaIDlxRbYKVK4nWhe-mK3--t5yrUfBJcZtfsbi7xEPEVbAZl3fsms2NtiuUbZfadxJtm12~iimOyMfpyyDVTHGIr9LUESkRPPmqfwGSlNMUhGVuSYXY-RKJEE5MBZUz79vYlVo9AtJrlYj0EinHBV2ge34ccfUAAbVerCi~ITP3H7D0mO-eYG0D7JnTdWbsKKLsHSGSSknF7EN-ulkbTVQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Molecular_surveillance_of_true_nontypeable_Haemophilus_influenzae_an_evaluation_of_PCR_screening_assays","translated_slug":"","page_count":8,"language":"en","content_type":"Work","owner":{"id":147569031,"first_name":"Michael","middle_initials":null,"last_name":"Binks","page_name":"MichaelBinks","domain_name":"independent","created_at":"2020-02-27T19:41:19.082-08:00","display_name":"Michael Binks","url":"https://independent.academia.edu/MichaelBinks"},"attachments":[{"id":66816018,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/66816018/thumbnails/1.jpg","file_name":"Molecular_surveillance_of_true_nontypeab20210503-2906-1dttgpa.pdf","download_url":"https://www.academia.edu/attachments/66816018/download_file?st=MTczMzA3OTIyOSw4LjIyMi4yMDguMTQ2&st=MTczMzA3OTIyOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Molecular_surveillance_of_true_nontypeab.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/66816018/Molecular_surveillance_of_true_nontypeab20210503-2906-1dttgpa.pdf?1620089301=\u0026response-content-disposition=attachment%3B+filename%3DMolecular_surveillance_of_true_nontypeab.pdf\u0026Expires=1733082828\u0026Signature=GJhXxu~VoMVLOwjyeh4fDBEmEeoaKJzX1iafFNdzE~kFljnmVwuCWtGz9kAX0lKOZQDvXjijLLwTzA8ZxBoCyy5ior5f6UjsXJAAC8p5PLC~wm6VgMSb3hcFcqvHAFSvZaIDlxRbYKVK4nWhe-mK3--t5yrUfBJcZtfsbi7xEPEVbAZl3fsms2NtiuUbZfadxJtm12~iimOyMfpyyDVTHGIr9LUESkRPPmqfwGSlNMUhGVuSYXY-RKJEE5MBZUz79vYlVo9AtJrlYj0EinHBV2ge34ccfUAAbVerCi~ITP3H7D0mO-eYG0D7JnTdWbsKKLsHSGSSknF7EN-ulkbTVQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary"},{"id":54433,"name":"Phylogeny","url":"https://www.academia.edu/Documents/in/Phylogeny"},{"id":194916,"name":"ROC Curve","url":"https://www.academia.edu/Documents/in/ROC_Curve"},{"id":213897,"name":"Phenotype","url":"https://www.academia.edu/Documents/in/Phenotype"},{"id":220780,"name":"PLoS one","url":"https://www.academia.edu/Documents/in/PLoS_one"},{"id":809882,"name":"Base Sequence","url":"https://www.academia.edu/Documents/in/Base_Sequence"},{"id":1186610,"name":"DNA binding proteins","url":"https://www.academia.edu/Documents/in/DNA_binding_proteins"},{"id":1990998,"name":"Haemophilus influenzae","url":"https://www.academia.edu/Documents/in/Haemophilus_influenzae"},{"id":2940273,"name":"real time polymerase chain reaction","url":"https://www.academia.edu/Documents/in/real_time_polymerase_chain_reaction"}],"urls":[{"id":9929998,"url":"http://dx.doi.org/10.1371/journal.pone.0034083"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="47950074"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/47950074/Whole_Genome_Characterization_and_Genotyping_of_Global_WU_Polyomavirus_Strains"><img alt="Research paper thumbnail of Whole-Genome Characterization and Genotyping of Global WU Polyomavirus Strains" class="work-thumbnail" src="https://attachments.academia-assets.com/66816019/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/47950074/Whole_Genome_Characterization_and_Genotyping_of_Global_WU_Polyomavirus_Strains">Whole-Genome Characterization and Genotyping of Global WU Polyomavirus Strains</a></div><div class="wp-workCard_item"><span>Journal of Virology</span><span>, 2010</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="833ee910983e1bffd6a87dd741a2de01" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":66816019,"asset_id":47950074,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/66816019/download_file?st=MTczMzA3OTIyOSw4LjIyMi4yMDguMTQ2&st=MTczMzA3OTIyOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="47950074"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="47950074"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 47950074; 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Using whole-genome sequencing of 48 WUV strains collected in four continents over a 5-year period and 16 publicly available whole-genome sequences, we identified three main WUV clades and five subtypes, provisionally termed Ia, Ib, Ic, II, IIIa, and IIIb. Overall nucleotide variation was low (0 to 1.2%). 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The purpose of this study was to characterize carriage isolates of NSP from Indigenous children vaccinated with the seven-valent pneumococcal conjugate vaccine (PCV7) and to use these data to guide decisions on reporting of NSP. A total of 182 NSP were characterized by BOX typing, antibiogram analysis, and multilocus sequence typing (MLST) of common BOX types. NSP positive for the wzg capsule gene were analyzed by a multiplex PCR-based reverse line blot hybridization assay (mPCR/RLB-H) targeting capsule genes to determine the serotype. Among 182 NSP, 49 BOX types were identified. MLST of 10 representative isolates found 7 STs, including ST448 (which accounted for 11% of NSP). Non-penicillin susceptibility was evident in 51% of the isolates. Pneumococcal wzg sequences were detected in only 23 (13%) NSP, including 10 that contained an ϳ1.2-kb insert in the region. mPCR/RLB-H identified serotype 14 wzy sequences in all 10 NSP, and 1 also contained a serotype 3-specific wze sequence. Among the remaining 13 wzg-positive NSP, few belonged to the serotypes represented in PCV7. It appears that most NSP identified in Australian Indigenous children are from a true nonencapsulated lineage. Few NSP represented serotypes in PCV7 that suppress capsular expression. High rates of carriage and penicillin resistance and the occasional presence of capsule genes suggest a role for NSP in the maintenance and survival of capsulated pneumococci. To avoid the inflation of pneumococcal carriage and antibiotic resistance rates, in clinical trials, we recommend separate reporting of rates of capsular strains and NSP and the exclusion of data for NSP from primary analyses.","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"Journal of Clinical 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pneumoniae","url":"https://www.academia.edu/Documents/in/Streptococcus_pneumoniae"},{"id":43665,"name":"Molecular Epidemiology","url":"https://www.academia.edu/Documents/in/Molecular_Epidemiology"},{"id":43666,"name":"Clinical Microbiology","url":"https://www.academia.edu/Documents/in/Clinical_Microbiology"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child"},{"id":99708,"name":"Clinical","url":"https://www.academia.edu/Documents/in/Clinical"},{"id":113903,"name":"Bacteria","url":"https://www.academia.edu/Documents/in/Bacteria"},{"id":134041,"name":"DNA fingerprinting","url":"https://www.academia.edu/Documents/in/DNA_fingerprinting"},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant"},{"id":213897,"name":"Phenotype","url":"https://www.academia.edu/Documents/in/Phenotype"},{"id":253560,"name":"Newborn 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PCR-High-Resolution Melt Assay for Rapid Differentiation of Nontypeable Haemophilus influenzae and Haemophilus haemolyticus" class="work-thumbnail" src="https://attachments.academia-assets.com/66816016/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/47950069/A_PCR_High_Resolution_Melt_Assay_for_Rapid_Differentiation_of_Nontypeable_Haemophilus_influenzae_and_Haemophilus_haemolyticus">A PCR-High-Resolution Melt Assay for Rapid Differentiation of Nontypeable Haemophilus influenzae and Haemophilus haemolyticus</a></div><div class="wp-workCard_item"><span>Journal of Clinical Microbiology</span><span>, 2014</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e0154131630390dc8a18e0eaea222bb0" 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