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Its role in the follow up of patients with gastric lymphoma following organ conserving strategies has not been established. Aim: To compare endosonographic response assessment with results of histological evaluation. Patients and methods: Thirty three patients with primary gastric lymphomas underwent pretreatment EUS and were followed endosonographically every 3–6 months after administration of organ conserving treatment modalities. A wall thickness of ≤4 mm with preserved five layer structure and the absence of suspicious lymph nodes was defined as endosonographic remission. Decrease in wall thickness, increase in echogenicity, and regression of lymph nodes were tested for their value to predict histological remission. Results: A total of 158 endosonographies were performed (median 4; range 2–12). Within a median follow up period of 15 months (range 3–48), 27 (82%) patients achieved complete histological remission while endosonographic remission was found in 21 (64%) patients. Eighteen patients achieved both forms of remission, with endosonographic remission occurring later (35.1 (11–212.9) weeks v 17.6 (11–97.9) weeks; median (range); p<0.02) than histological remission. A further three patients demonstrated a false negative remission on EUS. Histological relapse was paralleled by endosonographic relapse in only one of five patients. None of the tested endosonographic parameters was able to predict histological remission. Conclusions: In view of the inferior accuracy of EUS when compared with histology, gastroscopy with biopsy seems sufficient for the routine follow up of patients with gastric lymphoma." /> <meta name="DC.Contributor" content="A Püspök" /> <meta name="DC.Contributor" content="M Raderer" /> <meta name="DC.Contributor" content="A Chott" /> <meta name="DC.Contributor" content="B Dragosics" /> <meta name="DC.Contributor" content="A Gangl" /> <meta name="DC.Contributor" content="R Schöfl" /> <meta name="article:published_time" content="2002-11-01" /> <meta name="article:section" content="Gastrointestinal cancer" /> <meta name="citation_title" content="Endoscopic ultrasound in the follow up and response assessment of patients with primary gastric lymphoma" /> <meta name="citation_abstract" lang="en" content="<p><b>Background:</b> Endoscopic ultrasound (EUS) is considered the best technique for local staging of primary gastric lymphomas. Its role in the follow up of patients with gastric lymphoma following organ conserving strategies has not been established.</p><p><b>Aim:</b> To compare endosonographic response assessment with results of histological evaluation.</p><p><b>Patients and methods:</b> Thirty three patients with primary gastric lymphomas underwent pretreatment EUS and were followed endosonographically every 3–6 months after administration of organ conserving treatment modalities. A wall thickness of ≤4 mm with preserved five layer structure and the absence of suspicious lymph nodes was defined as endosonographic remission. Decrease in wall thickness, increase in echogenicity, and regression of lymph nodes were tested for their value to predict histological remission.</p><p><b>Results:</b> A total of 158 endosonographies were performed (median 4; range 2–12). Within a median follow up period of 15 months (range 3–48), 27 (82%) patients achieved complete histological remission while endosonographic remission was found in 21 (64%) patients. Eighteen patients achieved both forms of remission, with endosonographic remission occurring later (35.1 (11–212.9) weeks <i>v</i> 17.6 (11–97.9) weeks; median (range); p&lt;0.02) than histological remission. A further three patients demonstrated a false negative remission on EUS. Histological relapse was paralleled by endosonographic relapse in only one of five patients. None of the tested endosonographic parameters was able to predict histological remission.</p><p><b>Conclusions:</b> In view of the inferior accuracy of EUS when compared with histology, gastroscopy with biopsy seems sufficient for the routine follow up of patients with gastric lymphoma.</p>" /> <meta name="citation_journal_title" content="Gut" /> <meta name="citation_publisher" content="BMJ Publishing Group" /> <meta name="citation_publication_date" content="2002/11/01" /> <meta name="citation_mjid" content="gutjnl;51/5/691" /> <meta name="citation_id" content="51/5/691" /> <meta name="citation_public_url" content="https://gut.bmj.com/content/51/5/691" /> <meta name="citation_abstract_html_url" content="https://gut.bmj.com/content/51/5/691.abstract" /> <meta name="citation_full_html_url" content="https://gut.bmj.com/content/51/5/691.full" /> <meta name="citation_pdf_url" content="https://gut.bmj.com/content/gutjnl/51/5/691.full.pdf" /> <meta name="citation_issn" content="0017-5749" /> <meta name="citation_issn" content="1468-3288" /> <meta name="citation_doi" content="10.1136/gut.51.5.691" /> <meta name="citation_pmid" content="12377808" /> <meta name="citation_volume" content="51" /> <meta name="citation_issue" content="5" /> <meta name="citation_article_type" content="Other" /> <meta name="citation_section" content="Gastrointestinal cancer" /> <meta name="citation_firstpage" content="691" /> <meta name="citation_lastpage" content="694" /> <meta name="citation_author" content="A Püspök" /> <meta name="citation_author" content="M Raderer" /> <meta name="citation_author" content="A Chott" /> <meta name="citation_author" content="B Dragosics" /> <meta name="citation_author" content="A Gangl" /> <meta name="citation_author" content="R Schöfl" /> <meta name="citation_reference" content="citation_title=Lancet;citation_journal_abbrev=Lancet;citation_title=Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori.;citation_pages=575-577;citation_volume=342;citation_year=1993;citation_issue=8871;citation_pmid=8102719;citation_doi=10.1016/0140-6736(93)91409-F" /> <meta name="citation_reference" content="citation_title=Annals of Internal Medicine;citation_journal_abbrev=ANN INTERN MED;citation_title=Eradication of Helicobacter pylori Infection in Primary Low-Grade Gastric Lymphoma of Mucosa-Associated Lymphoid Tissue;citation_pages=767-769;citation_volume=122;citation_year=1995;citation_issue=10;citation_issn=0003-4819;citation_pmid=7717599;citation_doi=10.7326/0003-4819-122-10-199505150-00006" /> <meta name="citation_reference" content="citation_title=Gastroenterology;citation_journal_abbrev=Gastroenterology;citation_title=Regression of gastric MALT lymphoma after eradication of Helicobacter pylori is predicted by endosonographic staging. 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Its role in the follow up of patients with gastric lymphoma following organ conserving strategies has not been established. Aim: To compare endosonographic response assessment with results of histological evaluation. Patients and methods: Thirty three patients with primary gastric lymphomas underwent pretreatment EUS and were followed endosonographically every 3–6 months after administration of organ conserving treatment modalities. A wall thickness of ≤4 mm with preserved five layer structure and the absence of suspicious lymph nodes was defined as endosonographic remission. Decrease in wall thickness, increase in echogenicity, and regression of lymph nodes were tested for their value to predict histological remission. Results: A total of 158 endosonographies were performed (median 4; range 2–12). Within a median follow up period of 15 months (range 3–48), 27 (82%) patients achieved complete histological remission while endosonographic remission was found in 21 (64%) patients. Eighteen patients achieved both forms of remission, with endosonographic remission occurring later (35.1 (11–212.9) weeks v 17.6 (11–97.9) weeks; median (range); p<0.02) than histological remission. A further three patients demonstrated a false negative remission on EUS. Histological relapse was paralleled by endosonographic relapse in only one of five patients. None of the tested endosonographic parameters was able to predict histological remission. Conclusions: In view of the inferior accuracy of EUS when compared with histology, gastroscopy with biopsy seems sufficient for the routine follow up of patients with gastric lymphoma." /> <meta name="og-title" property="og:title" content="Endoscopic ultrasound in the follow up and response assessment of patients with primary gastric lymphoma" /> <meta name="og-url" property="og:url" content="https://gut.bmj.com/content/51/5/691" /> <meta name="og-site-name" property="og:site_name" content="Gut" /> <meta name="og-description" property="og:description" content="Background: Endoscopic ultrasound (EUS) is considered the best technique for local staging of primary gastric lymphomas. Its role in the follow up of patients with gastric lymphoma following organ conserving strategies has not been established. Aim: To compare endosonographic response assessment with results of histological evaluation. Patients and methods: Thirty three patients with primary gastric lymphomas underwent pretreatment EUS and were followed endosonographically every 3–6 months after administration of organ conserving treatment modalities. A wall thickness of ≤4 mm with preserved five layer structure and the absence of suspicious lymph nodes was defined as endosonographic remission. Decrease in wall thickness, increase in echogenicity, and regression of lymph nodes were tested for their value to predict histological remission. Results: A total of 158 endosonographies were performed (median 4; range 2–12). Within a median follow up period of 15 months (range 3–48), 27 (82%) patients achieved complete histological remission while endosonographic remission was found in 21 (64%) patients. Eighteen patients achieved both forms of remission, with endosonographic remission occurring later (35.1 (11–212.9) weeks v 17.6 (11–97.9) weeks; median (range); p<0.02) than histological remission. A further three patients demonstrated a false negative remission on EUS. Histological relapse was paralleled by endosonographic relapse in only one of five patients. None of the tested endosonographic parameters was able to predict histological remission. Conclusions: In view of the inferior accuracy of EUS when compared with histology, gastroscopy with biopsy seems sufficient for the routine follow up of patients with gastric lymphoma." /> <meta name="og-type" property="og:type" content="article" /> <meta name="og-image" property="og:image" content="https://gut.bmj.com/sites/default/files/highwire/gutjnl/51/5.cover.gif" /> <link rel="alternate" type="application/vnd.ms-powerpoint" title="Powerpoint" href="/content/51/5/691.ppt" /> <title>Endoscopic ultrasound in the follow up and response assessment of patients with primary gastric lymphoma | Gut</title> <link type="text/css" rel="stylesheet" href="/sites/default/files/advagg_css/css__ObQhdMjl2fcVYw7cUnTSJOCRp8wi20mzL5eTxYpVE_8__RHEb_wh5Am_m47OXrIid5l_odaVtTV0NCc_a-QHU5o0__dGRtyN8GJBuhBvXCmXEhVK4mGQl3ZIewHeJUeSvfyQ0.css" media="all" />  <script src="https://cookie-cdn.cookiepro.com/scripttemplates/otSDKStub.js" type="text/javascript" charset="UTF-8" data-domain-script="565e50dd-f6e9-46d6-91cd-5c40a270264f"></script> <script type="text/javascript"> function OnetrustAdsConsent(){ if(googletag.apiReady){ //console.log("GoogleTag API ready") googletag.pubads().disableInitialLoad(); if(OptanonActiveGroups.match(/,4,/)){ googletag.pubads().setRequestNonPersonalizedAds(0); //googletag.pubads().refresh(); } else{ googletag.pubads().setRequestNonPersonalizedAds(1); googletag.pubads().refresh(); } } else{ OnetrustAdsConsent(); } } function OptanonWrapper() { OnetrustAdsConsent(); } </script>  <script type="text/javascript" src="/sites/default/files/advagg_js/js__DdxPgqGimsdUot2QWNz_pGsHzqNGpx6RMCWHpL8YWkg__c6zfK6oHHbLpTal5PdQxeQI3xGoCM8IXWtEHwIZr560__dGRtyN8GJBuhBvXCmXEhVK4mGQl3ZIewHeJUeSvfyQ0.js"></script> <script type="text/javascript" src="https://securepubads.g.doubleclick.net/tag/js/gpt.js"></script> <script type="text/javascript" src="/sites/default/files/advagg_js/js__RplUf5n1SHvT_MHHQProZaAaHxo7a_9YZuaKWYnqVeQ__t8vznsHJmtJcTuSP5JnWJ92mdmFUGaXxtxwBatvNwmc__dGRtyN8GJBuhBvXCmXEhVK4mGQl3ZIewHeJUeSvfyQ0.js"></script> <script type="text/javascript" src="https://d1bxh8uas1mnw7.cloudfront.net/assets/embed.js"></script> <script type="text/javascript" src="/sites/default/files/advagg_js/js__dNRQ0P3mzXReUF4250f2vTnR4K_GFl-M8oB_3K2j1fI__-eoy5F1B5hwy20bysxSQQrr2HBlAB7kgfK-OIh8VRRA__dGRtyN8GJBuhBvXCmXEhVK4mGQl3ZIewHeJUeSvfyQ0.js"></script> <script type="text/javascript" defer="defer" async="async" src="//cdn.foxycart.com/bmjpg.ecommerce.highwire.org/loader.js"></script> <script type="text/javascript" async="async" src="https://scholar.google.com/scholar_js/casa.js"></script> <script type="text/javascript"> <![CDATA[//><!]]> </script> <script type="text/javascript"> <![CDATA[//><!]]> </script> <script type="text/javascript"> <![CDATA[//><!]]> </script> <script type="text/javascript"> <![CDATA[//><!]]> </script> <script type="text/javascript"> <![CDATA[//><!]]> </script> <script type="text/javascript"> <![CDATA[//><!]]> </script> <script type="text/javascript"> <![CDATA[//><!]]> </script> <script type="text/javascript"> <![CDATA[//><!]]> </script> <script type="text/javascript"> <![CDATA[//><!]]> </script> <script type="text/javascript"> <![CDATA[//><!]]> </script> <script type="text/javascript"> <![CDATA[//><!]]> </script>   <script> let cookies = parseCookies(); let bmj_uuid = cookies.bmj_uuid; let bmj_ppid = cookies.bmj_ppid; window.dataLayer = window.dataLayer || []; const anonMailId = 'e3b0c44298fc1c149afbf4c8996fb92427ae41e4649b934ca495991b7852b855'; function checkUserLoginStatus(dataLayer) { const userMail = dataLayer.find((item) => item.user)?.user?.mail; if (!userMail) { return false; } return userMail !== anonMailId; } let nonAnonMailId = ((dataLayer.find(item => item.user)?.user)?.mail) === anonMailId ? null : (dataLayer.find(item => item.user)?.user)?.mail; let userId = ((dataLayer.find(item => item.user)?.user)?.['data-ics']) ?? 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class="field-items"><div class="field-item even">Gastrointestinal cancer</div></div></div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-highwire-article-citation col-mobile-10 col-narrow-10 col-normal-11 article-title" > <div class="pane-content"> <div class="highwire-article-citation highwire-citation-type-highwire-article node147972" data-node-nid="147972" id="node-147972--2649033717" data-pisa="gutjnl;51/5/691" data-pisa-master="gutjnl;51/5/691" data-apath="/gutjnl/51/5/691.atom"><cite class="highwire-cite highwire-cite-highwire-article highwire-citation-bmjj-title clearfix"> <div class="highwire-cite-title">Endoscopic ultrasound in the follow up and response assessment of patients with primary gastric lymphoma</div> <span class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="gutjnl;51/5/691" data-atom-uri="/gutjnl/51/5/691.atom" data-request-view="full"></span></span> </cite> </div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-highwire-panel-tabs-container col-narrow-12 clear" > <div class="pane-content"> <div data-panels-ajax-tab-preloaded="jnl_template_bmjj_tab_art" id="panels-ajax-tab-container-highwire_article_tabs" class="panels-ajax-tab-container"><div class="panels-ajax-tab-loading" style ="display:none"><img class="loading" src="https://gut.bmj.com/sites/all/modules/contrib/panels_ajax_tab/images/loading.gif" alt="Loading" title="Loading" /></div><div class="panels-ajax-tab-wrap-jnl_template_bmjj_tab_art"><div class="panel-display panel-1col clearfix" > <div class="panel-panel panel-col"> <div><div class="panel-pane pane-highwire-markup author-affiliates col-narrow-12 author-affiliates-corresp article" > <div class="pane-content"> <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" class="content-block-markup" xmlns:xhtml="http://www.w3.org/1999/xhtml"><div xmlns:xhtml="http://www.w3.org/1999/xhtml" class="contributors"><ol class="contributor-list" id="contrib-group-1"><li id="contrib-1"><span class="name">A Püspök</span><a id="xref-aff-1-1" class="xref-aff" href="#aff-1">1</a>, </li><li id="contrib-2"><span class="name">M Raderer</span><a id="xref-aff-2-1" class="xref-aff" href="#aff-2">2</a>, </li><li id="contrib-3"><span class="name">A Chott</span><a id="xref-aff-3-1" class="xref-aff" href="#aff-3">3</a>, </li><li id="contrib-4"><span class="name">B Dragosics</span><a id="xref-aff-4-1" class="xref-aff" href="#aff-4">4</a>, </li><li id="contrib-5"><span class="name">A Gangl</span><a id="xref-aff-1-2" class="xref-aff" href="#aff-1">1</a>, </li><li id="contrib-6"><span class="name">R Schöfl</span><a id="xref-aff-1-3" class="xref-aff" href="#aff-1">1</a></li></ol><ol class="affiliation-list"><li class="aff"><a id="aff-1" name="aff-1"></a><address><sup>1</sup>Division of Gastroenterology and Hepatology, Department of Internal Medicine IV, AKH, University of Vienna, Vienna, Austria </address></li><li class="aff"><a id="aff-2" name="aff-2"></a><address><sup>2</sup>Division of Oncology, Department of Internal Medicine I, AKH, University of Vienna, Vienna, Austria </address></li><li class="aff"><a id="aff-3" name="aff-3"></a><address><sup>3</sup>Department of Clinical Pathology, AKH, University of Vienna, Vienna, Austria </address></li><li class="aff"><a id="aff-4" name="aff-4"></a><address><sup>4</sup>Gesundheitszentrum Wien-Süd, Wiener Gebietskrankenkasse (WGKK), Vienna, Austria</address></li></ol><ol class="corresp-list"><li class="corresp" id="corresp-1"><span class="corresp-label"></span>Correspondence to:<br/> Dr A Püspök, Department of Internal Medicine IV, AKH, Division of Gastroenterology and Hepatology, Waehringergürtel 18-20, A-1090 Vienna, Austria;<br/> <span class="em-link"><span class="em-addr">andreas.puespoek{at}akh-wien.ac.at</span></span></li></ol></div></div></div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-highwire-markup abstract-with-bc" > <div class="pane-content"> <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" id="content-block" xmlns:xhtml="http://www.w3.org/1999/xhtml"><div class="article abstract-view"><span class="highwire-journal-article-marker-start"></span><div class="section abstract" id="abstract-1"><h2>Abstract</h2> <p id="p-1"><strong>Background:</strong> Endoscopic ultrasound (EUS) is considered the best technique for local staging of primary gastric lymphomas. Its role in the follow up of patients with gastric lymphoma following organ conserving strategies has not been established.</p> <p id="p-2"><strong>Aim:</strong> To compare endosonographic response assessment with results of histological evaluation.</p> <p id="p-3"><strong>Patients and methods:</strong> Thirty three patients with primary gastric lymphomas underwent pretreatment EUS and were followed endosonographically every 3–6 months after administration of organ conserving treatment modalities. A wall thickness of ≤4 mm with preserved five layer structure and the absence of suspicious lymph nodes was defined as endosonographic remission. Decrease in wall thickness, increase in echogenicity, and regression of lymph nodes were tested for their value to predict histological remission.</p> <p id="p-4"><strong>Results:</strong> A total of 158 endosonographies were performed (median 4; range 2–12). Within a median follow up period of 15 months (range 3–48), 27 (82%) patients achieved complete histological remission while endosonographic remission was found in 21 (64%) patients. Eighteen patients achieved both forms of remission, with endosonographic remission occurring later (35.1 (11–212.9) weeks <em>v</em> 17.6 (11–97.9) weeks; median (range); p<0.02) than histological remission. A further three patients demonstrated a false negative remission on EUS. Histological relapse was paralleled by endosonographic relapse in only one of five patients. None of the tested endosonographic parameters was able to predict histological remission.</p> <p id="p-5"><strong>Conclusions:</strong> In view of the inferior accuracy of EUS when compared with histology, gastroscopy with biopsy seems sufficient for the routine follow up of patients with gastric lymphoma.</p> </div><ul class="kwd-group KWD"><li class="kwd">endosonography</li><li class="kwd">mucosa associated lymphoid tissue</li><li class="kwd">gastric lymphoma</li></ul><ul class="kwd-group ABR"><li class="kwd">MALT, mucosa associated lymphoid tissue</li><li class="kwd">EUS, endoscopic ultrasound</li><li class="kwd">DLBCL, diffuse large B cell lymphoma</li></ul><span class="highwire-journal-article-marker-end"></span></div><span class="related-urls"></span></div></div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right" > <div class="pane-content"> <div id="dfp-ad-mpu-wrapper" class="dfp-tag-wrapper"> <div id="dfp-ad-mpu" class="dfp-tag-wrapper"> <script type="text/javascript"> googletag.cmd.push(function() { googletag.display("dfp-ad-mpu"); }); </script> </div> </div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-custom pane-1" > <div class="pane-content"> <p><a href="https://doi.org/10.1136/gut.51.5.691" target="_new">https://doi.org/10.1136/gut.51.5.691</a></p> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-highwire-altmetrics" > <h2 class="pane-title">Statistics from Altmetric.com</h2> <div class="pane-content"> <div data-badge-details="right" data-badge-type="medium-donut" data-doi="10.1136/gut.51.5.691" data-hide-no-mentions="true" class="altmetric-embed"></div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-bmjj-jumplinks" > <div class="pane-content"> <div class="highwire-list-wrapper"><div class="highwire-list"><ul></ul></div></div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-custom pane-2 permissions-box" > <h2 class="pane-title">Request Permissions</h2> <div class="pane-content"> <p>If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. 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