Flora Vaccarino, MD < Child Study Center

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crossorigin="anonymous" /> <script data-schema="ProfilePage" type="application/ld+json"> {"@type":"ProfilePage","mainEntity":{"@type":"Person","name":"Flora Vaccarino","description":"Flora Vaccarino is the Harris Professor at the Child Study Center and Professor in the Department of Neuroscience at Yale University. 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They then performed an extensive comparison of the organoid’s transcriptome and noncoding elements with isogenic postmortem human fetal cortex and characterized gene regulatory mechanisms that shape the earliest cell fate decisions in human cortical development. Her lab has generated an extensive collection of patient-derived iPSC lines to study altered gene regulatory mechanisms in Autism Spectrum Disorders. Her interests include human somatic genomic variation as a tool to study lineage specification in human embryonic development. She was one of the fiunding members of the Brain Somatic Mosaicism Network (BSMN), a multi-site consortium that studied somatic mosaicism and its implication for neuropsychiatric diseases. Vaccarino is a Fellow of American Association for the Advancement of Science and a member of the PsychENCODE the Somatic Mosaicism across Human Tissues ( SMaHT) Consortia.","url":"https://medicine.yale.edu/profile/flora-vaccarino/","email":"flora.vaccarino@yale.edu","telephone":"+12037374147","image":{"@type":"ImageObject","url":"https://ysm-res.cloudinary.com/image/upload/c_limit,f_auto,h_630,q_auto,w_1200/v1/yms/prod/35647f85-7587-4df1-8e91-c3a764ccd6cb","description":"2024-09-30-Flora-Vaccarino-","height":1200,"width":630,"@context":"http://schema.org"},"address":[],"workLocation":[],"honorificSuffix":["MD"],"award":[],"jobTitle":["Harris Professor in the Child Study Center"],"affiliation":[{"@type":"Organization","name":"Center for Brain & Mind Health","url":"https://medicine.yale.edu/brain-mind-health/","@context":"http://schema.org"},{"@type":"Organization","name":"Child & Adolescent Psychiatry Training Program","url":"https://medicine.yale.edu/childstudy/education-and-training/clinical-internships-residencies-and-fellowships/child-and-adolescent-psychiatry-fellowship/","@context":"http://schema.org"},{"@type":"Organization","name":"Child Study Center","url":"https://medicine.yale.edu/childstudy/","@context":"http://schema.org"},{"@type":"Organization","name":"Embryonic Stem Cell Research Oversight","@context":"http://schema.org"},{"@type":"Organization","name":"Interdepartmental Neuroscience Program","url":"https://medicine.yale.edu/inp/","@context":"http://schema.org"},{"@type":"Organization","name":"Kavli Institute for Neuroscience","url":"https://medicine.yale.edu/kavli/","@context":"http://schema.org"},{"@type":"Organization","name":"Neuroscience","url":"https://medicine.yale.edu/neuroscience/","@context":"http://schema.org"},{"@type":"Organization","name":"Neuroscience Track","url":"https://medicine.yale.edu/bbs/tracks/neuroscience/","@context":"http://schema.org"},{"@type":"Organization","name":"Program in Neurodevelopment and Regeneration","url":"https://medicine.yale.edu/neurodevelopment/","@context":"http://schema.org"},{"@type":"Organization","name":"Tic Disorder & Obsessive Compulsive Disorder Program","@context":"http://schema.org"},{"@type":"Organization","name":"Vaccarino Lab","url":"https://medicine.yale.edu/lab/vaccarino/","@context":"http://schema.org"},{"@type":"Organization","name":"WHRY Pilot Project Program Investigators","url":"https://medicine.yale.edu/whr/","@context":"http://schema.org"},{"@type":"Organization","name":"Women's Health Research at Yale","url":"https://medicine.yale.edu/whr/","@context":"http://schema.org"},{"@type":"Organization","name":"Wu Tsai Institute","url":"https://wti.yale.edu/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Center for Genomic Health","url":"https://medicine.yale.edu/ycgh/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Combined Program in the Biological and Biomedical Sciences (BBS)","url":"https://medicine.yale.edu/bbs/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Stem Cell Center","url":"https://medicine.yale.edu/stemcell/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Ventures","url":"https://ventures.yale.edu/","@context":"http://schema.org"}],"alumniOf":[{"@type":"Organization","name":"Yale University, School of Medicine, Psychiatry (1991)","@context":"http://schema.org"},{"@type":"Organization","name":"FIDIA-Georgetown Institute for the Neurosciences (1987)","@context":"http://schema.org"},{"@type":"Organization","name":"NIMH-Laboratory of Preclinical Pharmacology (1985)","@context":"http://schema.org"},{"@type":"Organization","name":"Padua University Medical University (1979)","@context":"http://schema.org"}],"sameAs":[],"@context":"http://schema.org"},"@context":"http://schema.org"} </script> <script data-schema="MedicalScholarlyArticle" type="application/ld+json"> {"@type":"MedicalScholarlyArticle","publicationType":"Journal Article","inLanguage":"en-US","headline":"Interneuron loss and microglia activation by transcriptome analyses in the basal ganglia of Tourette disorder.","url":"https://pubmed.ncbi.nlm.nih.gov/39892689","author":[{"@type":"Person","name":"Flora Vaccarino","description":"Flora Vaccarino is the Harris Professor at the Child Study Center and Professor in the Department of Neuroscience at Yale University. She received her MD from the University of Padova in Italy. She spent few years as Neuropharmacology Fellow at NIH, trained in clinical psychiatry at Yale, and then was a Research Fellow in developmental genetics at the Yale School of Medicine, where she raised through the ranks to Assistant, Associate and full Professor. Vaccarino leads a multidisciplinary research group working towards new directions for the study of mammalian brain development, particularly human, using stem cell biology and genomics as tools. She has been studying brain development in animal models for over 20 years, focusing on the role of growth factor receptor signaling in the regulation of stem cell behavior and cerebral cortex morphogenesis. Inspired by Sasai’s work, Vaccarino and her lab pioneered the generation of 3D brain organoids from induced pluripotent stem cells (iPSCs) in 2012, and showed that they recapitulate early fetal development of the human cerebral cortex. They then performed an extensive comparison of the organoid’s transcriptome and noncoding elements with isogenic postmortem human fetal cortex and characterized gene regulatory mechanisms that shape the earliest cell fate decisions in human cortical development. Her lab has generated an extensive collection of patient-derived iPSC lines to study altered gene regulatory mechanisms in Autism Spectrum Disorders. Her interests include human somatic genomic variation as a tool to study lineage specification in human embryonic development. She was one of the fiunding members of the Brain Somatic Mosaicism Network (BSMN), a multi-site consortium that studied somatic mosaicism and its implication for neuropsychiatric diseases. 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Interneuron loss and microglia activation by transcriptome analyses in the basal ganglia of Tourette disorder. Biol Psychiatry 2025 <a href=\"https://pubmed.ncbi.nlm.nih.gov/39892689\" target=\"_blank\">PMID: 39892689</a>, DOI: 10.1016/j.biopsych.2024.12.022.","@context":"http://schema.org"} </script> <script data-schema="MedicalScholarlyArticle" type="application/ld+json"> {"@type":"MedicalScholarlyArticle","publicationType":"Journal Article","inLanguage":"en-US","headline":"Chapter 53 Tourette syndrome","url":"https://doi.org/10.1016/b978-0-443-19176-3.00044-3","author":[{"@type":"Person","name":"Flora Vaccarino","description":"Flora Vaccarino is the Harris Professor at the Child Study Center and Professor in the Department of Neuroscience at Yale University. She received her MD from the University of Padova in Italy. She spent few years as Neuropharmacology Fellow at NIH, trained in clinical psychiatry at Yale, and then was a Research Fellow in developmental genetics at the Yale School of Medicine, where she raised through the ranks to Assistant, Associate and full Professor. Vaccarino leads a multidisciplinary research group working towards new directions for the study of mammalian brain development, particularly human, using stem cell biology and genomics as tools. She has been studying brain development in animal models for over 20 years, focusing on the role of growth factor receptor signaling in the regulation of stem cell behavior and cerebral cortex morphogenesis. Inspired by Sasai’s work, Vaccarino and her lab pioneered the generation of 3D brain organoids from induced pluripotent stem cells (iPSCs) in 2012, and showed that they recapitulate early fetal development of the human cerebral cortex. They then performed an extensive comparison of the organoid’s transcriptome and noncoding elements with isogenic postmortem human fetal cortex and characterized gene regulatory mechanisms that shape the earliest cell fate decisions in human cortical development. Her lab has generated an extensive collection of patient-derived iPSC lines to study altered gene regulatory mechanisms in Autism Spectrum Disorders. Her interests include human somatic genomic variation as a tool to study lineage specification in human embryonic development. She was one of the fiunding members of the Brain Somatic Mosaicism Network (BSMN), a multi-site consortium that studied somatic mosaicism and its implication for neuropsychiatric diseases. 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Chapter 53 Tourette syndrome. 2025, 951-962. <a href=\"https://doi.org/10.1016/b978-0-443-19176-3.00044-3\" target=\"_blank\">DOI: 10.1016/b978-0-443-19176-3.00044-3</a>.","@context":"http://schema.org"} </script> <script data-schema="MedicalScholarlyArticle" type="application/ld+json"> {"@type":"MedicalScholarlyArticle","publicationType":"Journal Article","inLanguage":"en-US","headline":"A framework for neural organoids, assembloids and transplantation studies","url":"https://pubmed.ncbi.nlm.nih.gov/39653126","author":[{"@type":"Person","name":"Flora Vaccarino","description":"Flora Vaccarino is the Harris Professor at the Child Study Center and Professor in the Department of Neuroscience at Yale University. She received her MD from the University of Padova in Italy. 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They then performed an extensive comparison of the organoid’s transcriptome and noncoding elements with isogenic postmortem human fetal cortex and characterized gene regulatory mechanisms that shape the earliest cell fate decisions in human cortical development. Her lab has generated an extensive collection of patient-derived iPSC lines to study altered gene regulatory mechanisms in Autism Spectrum Disorders. Her interests include human somatic genomic variation as a tool to study lineage specification in human embryonic development. She was one of the fiunding members of the Brain Somatic Mosaicism Network (BSMN), a multi-site consortium that studied somatic mosaicism and its implication for neuropsychiatric diseases. Vaccarino is a Fellow of American Association for the Advancement of Science and a member of the PsychENCODE the Somatic Mosaicism across Human Tissues ( SMaHT) Consortia.","url":"https://medicine.yale.edu/profile/flora-vaccarino/","email":"flora.vaccarino@yale.edu","telephone":"+12037374147","image":{"@type":"ImageObject","url":"https://ysm-res.cloudinary.com/image/upload/c_limit,f_auto,h_630,q_auto,w_1200/v1/yms/prod/35647f85-7587-4df1-8e91-c3a764ccd6cb","description":"2024-09-30-Flora-Vaccarino-","height":1200,"width":630,"@context":"http://schema.org"},"address":[],"workLocation":[],"honorificSuffix":["MD"],"award":[],"jobTitle":["Harris Professor in the Child Study Center"],"affiliation":[{"@type":"Organization","name":"Center for Brain & Mind Health","url":"https://medicine.yale.edu/brain-mind-health/","@context":"http://schema.org"},{"@type":"Organization","name":"Child & Adolescent Psychiatry Training Program","url":"https://medicine.yale.edu/childstudy/education-and-training/clinical-internships-residencies-and-fellowships/child-and-adolescent-psychiatry-fellowship/","@context":"http://schema.org"},{"@type":"Organization","name":"Child Study Center","url":"https://medicine.yale.edu/childstudy/","@context":"http://schema.org"},{"@type":"Organization","name":"Embryonic Stem Cell Research Oversight","@context":"http://schema.org"},{"@type":"Organization","name":"Interdepartmental Neuroscience Program","url":"https://medicine.yale.edu/inp/","@context":"http://schema.org"},{"@type":"Organization","name":"Kavli Institute for Neuroscience","url":"https://medicine.yale.edu/kavli/","@context":"http://schema.org"},{"@type":"Organization","name":"Neuroscience","url":"https://medicine.yale.edu/neuroscience/","@context":"http://schema.org"},{"@type":"Organization","name":"Neuroscience Track","url":"https://medicine.yale.edu/bbs/tracks/neuroscience/","@context":"http://schema.org"},{"@type":"Organization","name":"Program in Neurodevelopment and Regeneration","url":"https://medicine.yale.edu/neurodevelopment/","@context":"http://schema.org"},{"@type":"Organization","name":"Tic Disorder & Obsessive Compulsive Disorder Program","@context":"http://schema.org"},{"@type":"Organization","name":"Vaccarino Lab","url":"https://medicine.yale.edu/lab/vaccarino/","@context":"http://schema.org"},{"@type":"Organization","name":"WHRY Pilot Project Program Investigators","url":"https://medicine.yale.edu/whr/","@context":"http://schema.org"},{"@type":"Organization","name":"Women's Health Research at Yale","url":"https://medicine.yale.edu/whr/","@context":"http://schema.org"},{"@type":"Organization","name":"Wu Tsai Institute","url":"https://wti.yale.edu/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Center for Genomic Health","url":"https://medicine.yale.edu/ycgh/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Combined Program in the Biological and Biomedical Sciences (BBS)","url":"https://medicine.yale.edu/bbs/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Stem Cell Center","url":"https://medicine.yale.edu/stemcell/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Ventures","url":"https://ventures.yale.edu/","@context":"http://schema.org"}],"alumniOf":[{"@type":"Organization","name":"Yale University, School of Medicine, Psychiatry (1991)","@context":"http://schema.org"},{"@type":"Organization","name":"FIDIA-Georgetown Institute for the Neurosciences (1987)","@context":"http://schema.org"},{"@type":"Organization","name":"NIMH-Laboratory of Preclinical Pharmacology (1985)","@context":"http://schema.org"},{"@type":"Organization","name":"Padua University Medical University (1979)","@context":"http://schema.org"}],"sameAs":[],"@context":"http://schema.org"}],"description":"Pașca S, Arlotta P, Bateup H, Camp J, Cappello S, Gage F, Knoblich J, Kriegstein A, Lancaster M, Ming G, Novarino G, Okano H, Parmar M, Park I, Reiner O, Song H, Studer L, Takahashi J, Temple S, Testa G, Treutlein B, Vaccarino F, Vanderhaeghen P, Young-Pearse T. A framework for neural organoids, assembloids and transplantation studies. Nature 2024, 1-3. <a href=\"https://pubmed.ncbi.nlm.nih.gov/39653126\" target=\"_blank\">PMID: 39653126</a>, <a href=\"https://doi.org/10.1038/s41586-024-08487-6\" target=\"_blank\">DOI: 10.1038/s41586-024-08487-6</a>.","@context":"http://schema.org"} </script> <script data-schema="MedicalScholarlyArticle" type="application/ld+json"> {"@type":"MedicalScholarlyArticle","publicationType":"Journal Article","inLanguage":"en-US","headline":"Transgenerational transmission of post-zygotic mutations suggests symmetric contribution of first two blastome","url":"https://pubmed.ncbi.nlm.nih.gov/39438473","author":[{"@type":"Person","name":"Flora Vaccarino","description":"Flora Vaccarino is the Harris Professor at the Child Study Center and Professor in the Department of Neuroscience at Yale University. She received her MD from the University of Padova in Italy. She spent few years as Neuropharmacology Fellow at NIH, trained in clinical psychiatry at Yale, and then was a Research Fellow in developmental genetics at the Yale School of Medicine, where she raised through the ranks to Assistant, Associate and full Professor. Vaccarino leads a multidisciplinary research group working towards new directions for the study of mammalian brain development, particularly human, using stem cell biology and genomics as tools. She has been studying brain development in animal models for over 20 years, focusing on the role of growth factor receptor signaling in the regulation of stem cell behavior and cerebral cortex morphogenesis. Inspired by Sasai’s work, Vaccarino and her lab pioneered the generation of 3D brain organoids from induced pluripotent stem cells (iPSCs) in 2012, and showed that they recapitulate early fetal development of the human cerebral cortex. They then performed an extensive comparison of the organoid’s transcriptome and noncoding elements with isogenic postmortem human fetal cortex and characterized gene regulatory mechanisms that shape the earliest cell fate decisions in human cortical development. Her lab has generated an extensive collection of patient-derived iPSC lines to study altered gene regulatory mechanisms in Autism Spectrum Disorders. Her interests include human somatic genomic variation as a tool to study lineage specification in human embryonic development. She was one of the fiunding members of the Brain Somatic Mosaicism Network (BSMN), a multi-site consortium that studied somatic mosaicism and its implication for neuropsychiatric diseases. Vaccarino is a Fellow of American Association for the Advancement of Science and a member of the PsychENCODE the Somatic Mosaicism across Human Tissues ( SMaHT) Consortia.","url":"https://medicine.yale.edu/profile/flora-vaccarino/","email":"flora.vaccarino@yale.edu","telephone":"+12037374147","image":{"@type":"ImageObject","url":"https://ysm-res.cloudinary.com/image/upload/c_limit,f_auto,h_630,q_auto,w_1200/v1/yms/prod/35647f85-7587-4df1-8e91-c3a764ccd6cb","description":"2024-09-30-Flora-Vaccarino-","height":1200,"width":630,"@context":"http://schema.org"},"address":[],"workLocation":[],"honorificSuffix":["MD"],"award":[],"jobTitle":["Harris Professor in the Child Study Center"],"affiliation":[{"@type":"Organization","name":"Center for Brain & Mind Health","url":"https://medicine.yale.edu/brain-mind-health/","@context":"http://schema.org"},{"@type":"Organization","name":"Child & Adolescent Psychiatry Training Program","url":"https://medicine.yale.edu/childstudy/education-and-training/clinical-internships-residencies-and-fellowships/child-and-adolescent-psychiatry-fellowship/","@context":"http://schema.org"},{"@type":"Organization","name":"Child Study Center","url":"https://medicine.yale.edu/childstudy/","@context":"http://schema.org"},{"@type":"Organization","name":"Embryonic Stem Cell Research Oversight","@context":"http://schema.org"},{"@type":"Organization","name":"Interdepartmental Neuroscience Program","url":"https://medicine.yale.edu/inp/","@context":"http://schema.org"},{"@type":"Organization","name":"Kavli Institute for Neuroscience","url":"https://medicine.yale.edu/kavli/","@context":"http://schema.org"},{"@type":"Organization","name":"Neuroscience","url":"https://medicine.yale.edu/neuroscience/","@context":"http://schema.org"},{"@type":"Organization","name":"Neuroscience Track","url":"https://medicine.yale.edu/bbs/tracks/neuroscience/","@context":"http://schema.org"},{"@type":"Organization","name":"Program in Neurodevelopment and Regeneration","url":"https://medicine.yale.edu/neurodevelopment/","@context":"http://schema.org"},{"@type":"Organization","name":"Tic Disorder & Obsessive Compulsive Disorder Program","@context":"http://schema.org"},{"@type":"Organization","name":"Vaccarino Lab","url":"https://medicine.yale.edu/lab/vaccarino/","@context":"http://schema.org"},{"@type":"Organization","name":"WHRY Pilot Project Program Investigators","url":"https://medicine.yale.edu/whr/","@context":"http://schema.org"},{"@type":"Organization","name":"Women's Health Research at Yale","url":"https://medicine.yale.edu/whr/","@context":"http://schema.org"},{"@type":"Organization","name":"Wu Tsai Institute","url":"https://wti.yale.edu/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Center for Genomic Health","url":"https://medicine.yale.edu/ycgh/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Combined Program in the Biological and Biomedical Sciences (BBS)","url":"https://medicine.yale.edu/bbs/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Stem Cell Center","url":"https://medicine.yale.edu/stemcell/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Ventures","url":"https://ventures.yale.edu/","@context":"http://schema.org"}],"alumniOf":[{"@type":"Organization","name":"Yale University, School of Medicine, Psychiatry (1991)","@context":"http://schema.org"},{"@type":"Organization","name":"FIDIA-Georgetown Institute for the Neurosciences (1987)","@context":"http://schema.org"},{"@type":"Organization","name":"NIMH-Laboratory of Preclinical Pharmacology (1985)","@context":"http://schema.org"},{"@type":"Organization","name":"Padua University Medical University (1979)","@context":"http://schema.org"}],"sameAs":[],"@context":"http://schema.org"}],"description":"Jang Y, Tomasini L, Bae T, Szekely A, Vaccarino F, Abyzov A. Transgenerational transmission of post-zygotic mutations suggests symmetric contribution of first two blastomeres to human germline. Nature Communications 2024, 15: 9117. <a href=\"https://pubmed.ncbi.nlm.nih.gov/39438473\" target=\"_blank\">PMID: 39438473</a>, <a href=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11496613\" target=\"_blank\">PMCID: PMC11496613</a>, <a href=\"https://doi.org/10.1038/s41467-024-53485-x\" target=\"_blank\">DOI: 10.1038/s41467-024-53485-x</a>.","@context":"http://schema.org"} </script> <script data-schema="MedicalScholarlyArticle" type="application/ld+json"> {"@type":"MedicalScholarlyArticle","publicationType":"Journal Article","inLanguage":"en-US","headline":"Tourette syndrome","author":[{"@type":"Person","name":"Flora Vaccarino","description":"Flora Vaccarino is the Harris Professor at the Child Study Center and Professor in the Department of Neuroscience at Yale University. She received her MD from the University of Padova in Italy. She spent few years as Neuropharmacology Fellow at NIH, trained in clinical psychiatry at Yale, and then was a Research Fellow in developmental genetics at the Yale School of Medicine, where she raised through the ranks to Assistant, Associate and full Professor. Vaccarino leads a multidisciplinary research group working towards new directions for the study of mammalian brain development, particularly human, using stem cell biology and genomics as tools. She has been studying brain development in animal models for over 20 years, focusing on the role of growth factor receptor signaling in the regulation of stem cell behavior and cerebral cortex morphogenesis. Inspired by Sasai’s work, Vaccarino and her lab pioneered the generation of 3D brain organoids from induced pluripotent stem cells (iPSCs) in 2012, and showed that they recapitulate early fetal development of the human cerebral cortex. They then performed an extensive comparison of the organoid’s transcriptome and noncoding elements with isogenic postmortem human fetal cortex and characterized gene regulatory mechanisms that shape the earliest cell fate decisions in human cortical development. Her lab has generated an extensive collection of patient-derived iPSC lines to study altered gene regulatory mechanisms in Autism Spectrum Disorders. Her interests include human somatic genomic variation as a tool to study lineage specification in human embryonic development. She was one of the fiunding members of the Brain Somatic Mosaicism Network (BSMN), a multi-site consortium that studied somatic mosaicism and its implication for neuropsychiatric diseases. Vaccarino is a Fellow of American Association for the Advancement of Science and a member of the PsychENCODE the Somatic Mosaicism across Human Tissues ( SMaHT) Consortia.","url":"https://medicine.yale.edu/profile/flora-vaccarino/","email":"flora.vaccarino@yale.edu","telephone":"+12037374147","image":{"@type":"ImageObject","url":"https://ysm-res.cloudinary.com/image/upload/c_limit,f_auto,h_630,q_auto,w_1200/v1/yms/prod/35647f85-7587-4df1-8e91-c3a764ccd6cb","description":"2024-09-30-Flora-Vaccarino-","height":1200,"width":630,"@context":"http://schema.org"},"address":[],"workLocation":[],"honorificSuffix":["MD"],"award":[],"jobTitle":["Harris Professor in the Child Study Center"],"affiliation":[{"@type":"Organization","name":"Center for Brain & Mind Health","url":"https://medicine.yale.edu/brain-mind-health/","@context":"http://schema.org"},{"@type":"Organization","name":"Child & Adolescent Psychiatry Training Program","url":"https://medicine.yale.edu/childstudy/education-and-training/clinical-internships-residencies-and-fellowships/child-and-adolescent-psychiatry-fellowship/","@context":"http://schema.org"},{"@type":"Organization","name":"Child Study Center","url":"https://medicine.yale.edu/childstudy/","@context":"http://schema.org"},{"@type":"Organization","name":"Embryonic Stem Cell Research Oversight","@context":"http://schema.org"},{"@type":"Organization","name":"Interdepartmental Neuroscience Program","url":"https://medicine.yale.edu/inp/","@context":"http://schema.org"},{"@type":"Organization","name":"Kavli Institute for Neuroscience","url":"https://medicine.yale.edu/kavli/","@context":"http://schema.org"},{"@type":"Organization","name":"Neuroscience","url":"https://medicine.yale.edu/neuroscience/","@context":"http://schema.org"},{"@type":"Organization","name":"Neuroscience Track","url":"https://medicine.yale.edu/bbs/tracks/neuroscience/","@context":"http://schema.org"},{"@type":"Organization","name":"Program in Neurodevelopment and Regeneration","url":"https://medicine.yale.edu/neurodevelopment/","@context":"http://schema.org"},{"@type":"Organization","name":"Tic Disorder & Obsessive Compulsive Disorder Program","@context":"http://schema.org"},{"@type":"Organization","name":"Vaccarino Lab","url":"https://medicine.yale.edu/lab/vaccarino/","@context":"http://schema.org"},{"@type":"Organization","name":"WHRY Pilot Project Program Investigators","url":"https://medicine.yale.edu/whr/","@context":"http://schema.org"},{"@type":"Organization","name":"Women's Health Research at Yale","url":"https://medicine.yale.edu/whr/","@context":"http://schema.org"},{"@type":"Organization","name":"Wu Tsai Institute","url":"https://wti.yale.edu/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Center for Genomic Health","url":"https://medicine.yale.edu/ycgh/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Combined Program in the Biological and Biomedical Sciences (BBS)","url":"https://medicine.yale.edu/bbs/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Stem Cell Center","url":"https://medicine.yale.edu/stemcell/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Ventures","url":"https://ventures.yale.edu/","@context":"http://schema.org"}],"alumniOf":[{"@type":"Organization","name":"Yale University, School of Medicine, Psychiatry (1991)","@context":"http://schema.org"},{"@type":"Organization","name":"FIDIA-Georgetown Institute for the Neurosciences (1987)","@context":"http://schema.org"},{"@type":"Organization","name":"NIMH-Laboratory of Preclinical Pharmacology (1985)","@context":"http://schema.org"},{"@type":"Organization","name":"Padua University Medical University (1979)","@context":"http://schema.org"}],"sameAs":[],"@context":"http://schema.org"}],"description":"Abdallah SB, Fasching L, Brady M, Bloch MH, Lombroso P, Vaccarino FM, Fernandez TV. Tourette syndrome. In: Rosenberg RN, Pascual JM, editors. Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease, Seventh Edition San Diego, CA: Elsevier/Academic Press; 2024. Chapter 53; p.951-962. ","@context":"http://schema.org"} </script> <script data-schema="MedicalScholarlyArticle" type="application/ld+json"> {"@type":"MedicalScholarlyArticle","publicationType":"Journal Article","inLanguage":"en-US","headline":"Elevated antibody binding to striatal cholinergic interneurons in patients with pediatric acute-onset neuropsy","url":"https://pubmed.ncbi.nlm.nih.gov/39084540","author":[{"@type":"Person","name":"Flora Vaccarino","description":"Flora Vaccarino is the Harris Professor at the Child Study Center and Professor in the Department of Neuroscience at Yale University. She received her MD from the University of Padova in Italy. She spent few years as Neuropharmacology Fellow at NIH, trained in clinical psychiatry at Yale, and then was a Research Fellow in developmental genetics at the Yale School of Medicine, where she raised through the ranks to Assistant, Associate and full Professor. Vaccarino leads a multidisciplinary research group working towards new directions for the study of mammalian brain development, particularly human, using stem cell biology and genomics as tools. She has been studying brain development in animal models for over 20 years, focusing on the role of growth factor receptor signaling in the regulation of stem cell behavior and cerebral cortex morphogenesis. Inspired by Sasai’s work, Vaccarino and her lab pioneered the generation of 3D brain organoids from induced pluripotent stem cells (iPSCs) in 2012, and showed that they recapitulate early fetal development of the human cerebral cortex. They then performed an extensive comparison of the organoid’s transcriptome and noncoding elements with isogenic postmortem human fetal cortex and characterized gene regulatory mechanisms that shape the earliest cell fate decisions in human cortical development. Her lab has generated an extensive collection of patient-derived iPSC lines to study altered gene regulatory mechanisms in Autism Spectrum Disorders. Her interests include human somatic genomic variation as a tool to study lineage specification in human embryonic development. She was one of the fiunding members of the Brain Somatic Mosaicism Network (BSMN), a multi-site consortium that studied somatic mosaicism and its implication for neuropsychiatric diseases. Vaccarino is a Fellow of American Association for the Advancement of Science and a member of the PsychENCODE the Somatic Mosaicism across Human Tissues ( SMaHT) Consortia.","url":"https://medicine.yale.edu/profile/flora-vaccarino/","email":"flora.vaccarino@yale.edu","telephone":"+12037374147","image":{"@type":"ImageObject","url":"https://ysm-res.cloudinary.com/image/upload/c_limit,f_auto,h_630,q_auto,w_1200/v1/yms/prod/35647f85-7587-4df1-8e91-c3a764ccd6cb","description":"2024-09-30-Flora-Vaccarino-","height":1200,"width":630,"@context":"http://schema.org"},"address":[],"workLocation":[],"honorificSuffix":["MD"],"award":[],"jobTitle":["Harris Professor in the Child Study Center"],"affiliation":[{"@type":"Organization","name":"Center for Brain & Mind Health","url":"https://medicine.yale.edu/brain-mind-health/","@context":"http://schema.org"},{"@type":"Organization","name":"Child & Adolescent Psychiatry Training Program","url":"https://medicine.yale.edu/childstudy/education-and-training/clinical-internships-residencies-and-fellowships/child-and-adolescent-psychiatry-fellowship/","@context":"http://schema.org"},{"@type":"Organization","name":"Child Study Center","url":"https://medicine.yale.edu/childstudy/","@context":"http://schema.org"},{"@type":"Organization","name":"Embryonic Stem Cell Research Oversight","@context":"http://schema.org"},{"@type":"Organization","name":"Interdepartmental Neuroscience Program","url":"https://medicine.yale.edu/inp/","@context":"http://schema.org"},{"@type":"Organization","name":"Kavli Institute for Neuroscience","url":"https://medicine.yale.edu/kavli/","@context":"http://schema.org"},{"@type":"Organization","name":"Neuroscience","url":"https://medicine.yale.edu/neuroscience/","@context":"http://schema.org"},{"@type":"Organization","name":"Neuroscience Track","url":"https://medicine.yale.edu/bbs/tracks/neuroscience/","@context":"http://schema.org"},{"@type":"Organization","name":"Program in Neurodevelopment and Regeneration","url":"https://medicine.yale.edu/neurodevelopment/","@context":"http://schema.org"},{"@type":"Organization","name":"Tic Disorder & Obsessive Compulsive Disorder Program","@context":"http://schema.org"},{"@type":"Organization","name":"Vaccarino Lab","url":"https://medicine.yale.edu/lab/vaccarino/","@context":"http://schema.org"},{"@type":"Organization","name":"WHRY Pilot Project Program Investigators","url":"https://medicine.yale.edu/whr/","@context":"http://schema.org"},{"@type":"Organization","name":"Women's Health Research at Yale","url":"https://medicine.yale.edu/whr/","@context":"http://schema.org"},{"@type":"Organization","name":"Wu Tsai Institute","url":"https://wti.yale.edu/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Center for Genomic Health","url":"https://medicine.yale.edu/ycgh/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Combined Program in the Biological and Biomedical Sciences (BBS)","url":"https://medicine.yale.edu/bbs/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Stem Cell Center","url":"https://medicine.yale.edu/stemcell/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Ventures","url":"https://ventures.yale.edu/","@context":"http://schema.org"}],"alumniOf":[{"@type":"Organization","name":"Yale University, School of Medicine, Psychiatry (1991)","@context":"http://schema.org"},{"@type":"Organization","name":"FIDIA-Georgetown Institute for the Neurosciences (1987)","@context":"http://schema.org"},{"@type":"Organization","name":"NIMH-Laboratory of Preclinical Pharmacology (1985)","@context":"http://schema.org"},{"@type":"Organization","name":"Padua University Medical University (1979)","@context":"http://schema.org"}],"sameAs":[],"@context":"http://schema.org"}],"description":"Xu J, Frankovich J, Liu R, Thienemann M, Silverman M, Farhadian B, Willett T, Manko C, Columbo L, Leibold C, Vaccarino F, Che A, Pittenger C. Elevated antibody binding to striatal cholinergic interneurons in patients with pediatric acute-onset neuropsychiatric syndrome. Brain Behavior And Immunity 2024, 122: 241-255. <a href=\"https://pubmed.ncbi.nlm.nih.gov/39084540\" target=\"_blank\">PMID: 39084540</a>, <a href=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11569416\" target=\"_blank\">PMCID: PMC11569416</a>, <a href=\"https://doi.org/10.1016/j.bbi.2024.07.044\" target=\"_blank\">DOI: 10.1016/j.bbi.2024.07.044</a>.","@context":"http://schema.org"} </script> <script data-schema="MedicalScholarlyArticle" type="application/ld+json"> {"@type":"MedicalScholarlyArticle","publicationType":"Journal Article","inLanguage":"en-US","headline":"Early Developmental Origins of Cortical Disorders Modeled in Human Neural Stem Cells.","url":"https://pubmed.ncbi.nlm.nih.gov/38915580","author":[{"@type":"Person","name":"Flora Vaccarino","description":"Flora Vaccarino is the Harris Professor at the Child Study Center and Professor in the Department of Neuroscience at Yale University. She received her MD from the University of Padova in Italy. She spent few years as Neuropharmacology Fellow at NIH, trained in clinical psychiatry at Yale, and then was a Research Fellow in developmental genetics at the Yale School of Medicine, where she raised through the ranks to Assistant, Associate and full Professor. Vaccarino leads a multidisciplinary research group working towards new directions for the study of mammalian brain development, particularly human, using stem cell biology and genomics as tools. She has been studying brain development in animal models for over 20 years, focusing on the role of growth factor receptor signaling in the regulation of stem cell behavior and cerebral cortex morphogenesis. Inspired by Sasai’s work, Vaccarino and her lab pioneered the generation of 3D brain organoids from induced pluripotent stem cells (iPSCs) in 2012, and showed that they recapitulate early fetal development of the human cerebral cortex. They then performed an extensive comparison of the organoid’s transcriptome and noncoding elements with isogenic postmortem human fetal cortex and characterized gene regulatory mechanisms that shape the earliest cell fate decisions in human cortical development. Her lab has generated an extensive collection of patient-derived iPSC lines to study altered gene regulatory mechanisms in Autism Spectrum Disorders. Her interests include human somatic genomic variation as a tool to study lineage specification in human embryonic development. She was one of the fiunding members of the Brain Somatic Mosaicism Network (BSMN), a multi-site consortium that studied somatic mosaicism and its implication for neuropsychiatric diseases. Vaccarino is a Fellow of American Association for the Advancement of Science and a member of the PsychENCODE the Somatic Mosaicism across Human Tissues ( SMaHT) Consortia.","url":"https://medicine.yale.edu/profile/flora-vaccarino/","email":"flora.vaccarino@yale.edu","telephone":"+12037374147","image":{"@type":"ImageObject","url":"https://ysm-res.cloudinary.com/image/upload/c_limit,f_auto,h_630,q_auto,w_1200/v1/yms/prod/35647f85-7587-4df1-8e91-c3a764ccd6cb","description":"2024-09-30-Flora-Vaccarino-","height":1200,"width":630,"@context":"http://schema.org"},"address":[],"workLocation":[],"honorificSuffix":["MD"],"award":[],"jobTitle":["Harris Professor in the Child Study Center"],"affiliation":[{"@type":"Organization","name":"Center for Brain & Mind Health","url":"https://medicine.yale.edu/brain-mind-health/","@context":"http://schema.org"},{"@type":"Organization","name":"Child & Adolescent Psychiatry Training Program","url":"https://medicine.yale.edu/childstudy/education-and-training/clinical-internships-residencies-and-fellowships/child-and-adolescent-psychiatry-fellowship/","@context":"http://schema.org"},{"@type":"Organization","name":"Child Study Center","url":"https://medicine.yale.edu/childstudy/","@context":"http://schema.org"},{"@type":"Organization","name":"Embryonic Stem Cell Research Oversight","@context":"http://schema.org"},{"@type":"Organization","name":"Interdepartmental Neuroscience Program","url":"https://medicine.yale.edu/inp/","@context":"http://schema.org"},{"@type":"Organization","name":"Kavli Institute for Neuroscience","url":"https://medicine.yale.edu/kavli/","@context":"http://schema.org"},{"@type":"Organization","name":"Neuroscience","url":"https://medicine.yale.edu/neuroscience/","@context":"http://schema.org"},{"@type":"Organization","name":"Neuroscience Track","url":"https://medicine.yale.edu/bbs/tracks/neuroscience/","@context":"http://schema.org"},{"@type":"Organization","name":"Program in Neurodevelopment and Regeneration","url":"https://medicine.yale.edu/neurodevelopment/","@context":"http://schema.org"},{"@type":"Organization","name":"Tic Disorder & Obsessive Compulsive Disorder Program","@context":"http://schema.org"},{"@type":"Organization","name":"Vaccarino Lab","url":"https://medicine.yale.edu/lab/vaccarino/","@context":"http://schema.org"},{"@type":"Organization","name":"WHRY Pilot Project Program Investigators","url":"https://medicine.yale.edu/whr/","@context":"http://schema.org"},{"@type":"Organization","name":"Women's Health Research at Yale","url":"https://medicine.yale.edu/whr/","@context":"http://schema.org"},{"@type":"Organization","name":"Wu Tsai Institute","url":"https://wti.yale.edu/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Center for Genomic Health","url":"https://medicine.yale.edu/ycgh/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Combined Program in the Biological and Biomedical Sciences (BBS)","url":"https://medicine.yale.edu/bbs/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Stem Cell Center","url":"https://medicine.yale.edu/stemcell/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Ventures","url":"https://ventures.yale.edu/","@context":"http://schema.org"}],"alumniOf":[{"@type":"Organization","name":"Yale University, School of Medicine, Psychiatry (1991)","@context":"http://schema.org"},{"@type":"Organization","name":"FIDIA-Georgetown Institute for the Neurosciences (1987)","@context":"http://schema.org"},{"@type":"Organization","name":"NIMH-Laboratory of Preclinical Pharmacology (1985)","@context":"http://schema.org"},{"@type":"Organization","name":"Padua University Medical University (1979)","@context":"http://schema.org"}],"sameAs":[],"@context":"http://schema.org"}],"description":"Mato-Blanco X, Kim SK, Jourdon A, Ma S, Tebbenkamp ATN, Liu F, Duque A, Vaccarino FM, Sestan N, Colantuoni C, Rakic P, Santpere G, Micali N. Early Developmental Origins of Cortical Disorders Modeled in Human Neural Stem Cells. BioRxiv 2024 <a href=\"https://pubmed.ncbi.nlm.nih.gov/38915580\" target=\"_blank\">PMID: 38915580</a>, DOI: 10.1101/2024.06.14.598925.","@context":"http://schema.org"} </script> <script data-schema="MedicalScholarlyArticle" type="application/ld+json"> {"@type":"MedicalScholarlyArticle","publicationType":"Journal Article","inLanguage":"en-US","headline":"Massively parallel characterization of regulatory elements in the developing human cortex","url":"https://pubmed.ncbi.nlm.nih.gov/38781390","author":[{"@type":"Person","name":"Flora Vaccarino","description":"Flora Vaccarino is the Harris Professor at the Child Study Center and Professor in the Department of Neuroscience at Yale University. She received her MD from the University of Padova in Italy. She spent few years as Neuropharmacology Fellow at NIH, trained in clinical psychiatry at Yale, and then was a Research Fellow in developmental genetics at the Yale School of Medicine, where she raised through the ranks to Assistant, Associate and full Professor. Vaccarino leads a multidisciplinary research group working towards new directions for the study of mammalian brain development, particularly human, using stem cell biology and genomics as tools. She has been studying brain development in animal models for over 20 years, focusing on the role of growth factor receptor signaling in the regulation of stem cell behavior and cerebral cortex morphogenesis. Inspired by Sasai’s work, Vaccarino and her lab pioneered the generation of 3D brain organoids from induced pluripotent stem cells (iPSCs) in 2012, and showed that they recapitulate early fetal development of the human cerebral cortex. They then performed an extensive comparison of the organoid’s transcriptome and noncoding elements with isogenic postmortem human fetal cortex and characterized gene regulatory mechanisms that shape the earliest cell fate decisions in human cortical development. Her lab has generated an extensive collection of patient-derived iPSC lines to study altered gene regulatory mechanisms in Autism Spectrum Disorders. Her interests include human somatic genomic variation as a tool to study lineage specification in human embryonic development. She was one of the fiunding members of the Brain Somatic Mosaicism Network (BSMN), a multi-site consortium that studied somatic mosaicism and its implication for neuropsychiatric diseases. Vaccarino is a Fellow of American Association for the Advancement of Science and a member of the PsychENCODE the Somatic Mosaicism across Human Tissues ( SMaHT) Consortia.","url":"https://medicine.yale.edu/profile/flora-vaccarino/","email":"flora.vaccarino@yale.edu","telephone":"+12037374147","image":{"@type":"ImageObject","url":"https://ysm-res.cloudinary.com/image/upload/c_limit,f_auto,h_630,q_auto,w_1200/v1/yms/prod/35647f85-7587-4df1-8e91-c3a764ccd6cb","description":"2024-09-30-Flora-Vaccarino-","height":1200,"width":630,"@context":"http://schema.org"},"address":[],"workLocation":[],"honorificSuffix":["MD"],"award":[],"jobTitle":["Harris Professor in the Child Study Center"],"affiliation":[{"@type":"Organization","name":"Center for Brain & Mind Health","url":"https://medicine.yale.edu/brain-mind-health/","@context":"http://schema.org"},{"@type":"Organization","name":"Child & Adolescent Psychiatry Training 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Track","url":"https://medicine.yale.edu/bbs/tracks/neuroscience/","@context":"http://schema.org"},{"@type":"Organization","name":"Program in Neurodevelopment and Regeneration","url":"https://medicine.yale.edu/neurodevelopment/","@context":"http://schema.org"},{"@type":"Organization","name":"Tic Disorder & Obsessive Compulsive Disorder Program","@context":"http://schema.org"},{"@type":"Organization","name":"Vaccarino Lab","url":"https://medicine.yale.edu/lab/vaccarino/","@context":"http://schema.org"},{"@type":"Organization","name":"WHRY Pilot Project Program Investigators","url":"https://medicine.yale.edu/whr/","@context":"http://schema.org"},{"@type":"Organization","name":"Women's Health Research at Yale","url":"https://medicine.yale.edu/whr/","@context":"http://schema.org"},{"@type":"Organization","name":"Wu Tsai Institute","url":"https://wti.yale.edu/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Center for Genomic Health","url":"https://medicine.yale.edu/ycgh/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Combined Program in the Biological and Biomedical Sciences (BBS)","url":"https://medicine.yale.edu/bbs/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Stem Cell Center","url":"https://medicine.yale.edu/stemcell/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Ventures","url":"https://ventures.yale.edu/","@context":"http://schema.org"}],"alumniOf":[{"@type":"Organization","name":"Yale University, School of Medicine, Psychiatry (1991)","@context":"http://schema.org"},{"@type":"Organization","name":"FIDIA-Georgetown Institute for the Neurosciences (1987)","@context":"http://schema.org"},{"@type":"Organization","name":"NIMH-Laboratory of Preclinical Pharmacology (1985)","@context":"http://schema.org"},{"@type":"Organization","name":"Padua University Medical University (1979)","@context":"http://schema.org"}],"sameAs":[],"@context":"http://schema.org"}],"description":"Deng C, Whalen S, Steyert M, Ziffra R, Przytycki P, Inoue F, Pereira D, Capauto D, Norton S, Vaccarino F, Pollen A, Nowakowski T, Ahituv N, Pollard K, Akbarian S, Abyzov A, Ahituv N, Arasappan D, Almagro Armenteros J, Beliveau B, Bendl J, Berretta S, Bharadwaj R, Bhattacharya A, Bicks L, Brennand K, Capauto D, Champagne F, Chatterjee T, Chatzinakos C, Chen Y, Chen H, Cheng Y, Cheng L, Chess A, Chien J, Chu Z, Clarke D, Clement A, Collado-Torres L, Cooper G, Crawford G, Dai R, Daskalakis N, Davila-Velderrain J, Deep-Soboslay A, Deng C, DiPietro C, Dracheva S, Drusinsky S, Duan Z, Duong D, Dursun C, Eagles N, Edelstein J, Emani P, Fullard J, Galani K, Galeev T, Gandal M, Gaynor S, Gerstein M, Geschwind D, Girdhar K, Goes F, Greenleaf W, Grundman J, Guo H, Guo Q, Gupta C, Hadas Y, Hallmayer J, Han X, Haroutunian V, Hawken N, He C, Henry E, Hicks S, Ho M, Ho L, Hoffman G, Huang Y, Huuki-Myers L, Hwang A, Hyde T, Iatrou A, Inoue F, Jajoo A, Jensen M, Jiang L, Jin P, Jin T, Jops C, Jourdon A, Kawaguchi R, Kellis M, Khullar S, Kleinman J, Kleopoulos S, Kozlenkov A, Kriegstein A, Kundaje A, Kundu S, Lee C, Lee D, Li J, Li M, Lin X, Liu S, Liu J, Liu J, Liu C, Liu S, Lou S, Loupe J, Lu D, Ma S, Ma L, Margolis M, Mariani J, Martinowich K, Maynard K, Mazariegos S, Meng R, Myers R, Micallef C, Mikhailova T, Ming G, Mohammadi S, Monte E, Montgomery K, Moore J, Moran J, Mukamel E, Nairn A, Nemeroff C, Ni P, Norton S, Nowakowski T, Omberg L, Page S, Park S, Patowary A, Pattni R, Pertea G, Peters M, Phalke N, Pinto D, Pjanic M, Pochareddy S, Pollard K, Pollen A, Pratt H, Przytycki P, Purmann C, Qin Z, Qu P, Quintero D, Raj T, Rajagopalan A, Reach S, Reimonn T, Ressler K, Ross D, Roussos P, Rozowsky J, Ruth M, Ruzicka W, Sanders S, Schneider J, Scuderi S, Sebra R, Sestan N, Seyfried N, Shao Z, Shedd N, Shieh A, Shin J, Skarica M, Snijders C, Song H, State M, Stein J, Steyert M, Subburaju S, Sudhof T, Snyder M, Tao R, Therrien K, Tsai L, Urban A, Vaccarino F, van Bakel H, Vo D, Voloudakis G, Wamsley B, Wang T, Wang S, Wang D, Wang Y, Warrell J, Wei Y, Weimer A, Weinberger D, Wen C, Weng Z, Whalen S, White K, Willsey A, Won H, Wong W, Wu H, Wu F, Wuchty S, Wylie D, Xu S, Yap C, Zeng B, Zhang P, Zhang C, Zhang B, Zhang J, Zhang Y, Zhou X, Ziffra R, Zeier Z, Zintel T. Massively parallel characterization of regulatory elements in the developing human cortex. Science 2024, 384: eadh0559. <a href=\"https://pubmed.ncbi.nlm.nih.gov/38781390\" target=\"_blank\">PMID: 38781390</a>, <a href=\"https://doi.org/10.1126/science.adh0559\" target=\"_blank\">DOI: 10.1126/science.adh0559</a>.","@context":"http://schema.org"} </script> <script data-schema="MedicalScholarlyArticle" type="application/ld+json"> {"@type":"MedicalScholarlyArticle","publicationType":"Journal Article","inLanguage":"en-US","headline":"Evaluating performance and applications of sample-wise cell deconvolution methods on human brain transcriptomi","url":"https://pubmed.ncbi.nlm.nih.gov/38781336","author":[{"@type":"Person","name":"Flora Vaccarino","description":"Flora Vaccarino is the Harris Professor at the Child Study Center and Professor in the Department of Neuroscience at Yale University. She received her MD from the University of Padova in Italy. She spent few years as Neuropharmacology Fellow at NIH, trained in clinical psychiatry at Yale, and then was a Research Fellow in developmental genetics at the Yale School of Medicine, where she raised through the ranks to Assistant, Associate and full Professor. Vaccarino leads a multidisciplinary research group working towards new directions for the study of mammalian brain development, particularly human, using stem cell biology and genomics as tools. She has been studying brain development in animal models for over 20 years, focusing on the role of growth factor receptor signaling in the regulation of stem cell behavior and cerebral cortex morphogenesis. Inspired by Sasai’s work, Vaccarino and her lab pioneered the generation of 3D brain organoids from induced pluripotent stem cells (iPSCs) in 2012, and showed that they recapitulate early fetal development of the human cerebral cortex. They then performed an extensive comparison of the organoid’s transcriptome and noncoding elements with isogenic postmortem human fetal cortex and characterized gene regulatory mechanisms that shape the earliest cell fate decisions in human cortical development. Her lab has generated an extensive collection of patient-derived iPSC lines to study altered gene regulatory mechanisms in Autism Spectrum Disorders. Her interests include human somatic genomic variation as a tool to study lineage specification in human embryonic development. She was one of the fiunding members of the Brain Somatic Mosaicism Network (BSMN), a multi-site consortium that studied somatic mosaicism and its implication for neuropsychiatric diseases. Vaccarino is a Fellow of American Association for the Advancement of Science and a member of the PsychENCODE the Somatic Mosaicism across Human Tissues ( SMaHT) Consortia.","url":"https://medicine.yale.edu/profile/flora-vaccarino/","email":"flora.vaccarino@yale.edu","telephone":"+12037374147","image":{"@type":"ImageObject","url":"https://ysm-res.cloudinary.com/image/upload/c_limit,f_auto,h_630,q_auto,w_1200/v1/yms/prod/35647f85-7587-4df1-8e91-c3a764ccd6cb","description":"2024-09-30-Flora-Vaccarino-","height":1200,"width":630,"@context":"http://schema.org"},"address":[],"workLocation":[],"honorificSuffix":["MD"],"award":[],"jobTitle":["Harris Professor in the Child Study Center"],"affiliation":[{"@type":"Organization","name":"Center for Brain & Mind Health","url":"https://medicine.yale.edu/brain-mind-health/","@context":"http://schema.org"},{"@type":"Organization","name":"Child & Adolescent Psychiatry Training Program","url":"https://medicine.yale.edu/childstudy/education-and-training/clinical-internships-residencies-and-fellowships/child-and-adolescent-psychiatry-fellowship/","@context":"http://schema.org"},{"@type":"Organization","name":"Child Study Center","url":"https://medicine.yale.edu/childstudy/","@context":"http://schema.org"},{"@type":"Organization","name":"Embryonic Stem Cell Research Oversight","@context":"http://schema.org"},{"@type":"Organization","name":"Interdepartmental Neuroscience Program","url":"https://medicine.yale.edu/inp/","@context":"http://schema.org"},{"@type":"Organization","name":"Kavli Institute for Neuroscience","url":"https://medicine.yale.edu/kavli/","@context":"http://schema.org"},{"@type":"Organization","name":"Neuroscience","url":"https://medicine.yale.edu/neuroscience/","@context":"http://schema.org"},{"@type":"Organization","name":"Neuroscience Track","url":"https://medicine.yale.edu/bbs/tracks/neuroscience/","@context":"http://schema.org"},{"@type":"Organization","name":"Program in Neurodevelopment and Regeneration","url":"https://medicine.yale.edu/neurodevelopment/","@context":"http://schema.org"},{"@type":"Organization","name":"Tic Disorder & Obsessive Compulsive Disorder Program","@context":"http://schema.org"},{"@type":"Organization","name":"Vaccarino Lab","url":"https://medicine.yale.edu/lab/vaccarino/","@context":"http://schema.org"},{"@type":"Organization","name":"WHRY Pilot Project Program Investigators","url":"https://medicine.yale.edu/whr/","@context":"http://schema.org"},{"@type":"Organization","name":"Women's Health Research at Yale","url":"https://medicine.yale.edu/whr/","@context":"http://schema.org"},{"@type":"Organization","name":"Wu Tsai Institute","url":"https://wti.yale.edu/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Center for Genomic Health","url":"https://medicine.yale.edu/ycgh/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Combined Program in the Biological and Biomedical Sciences (BBS)","url":"https://medicine.yale.edu/bbs/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Stem Cell Center","url":"https://medicine.yale.edu/stemcell/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Ventures","url":"https://ventures.yale.edu/","@context":"http://schema.org"}],"alumniOf":[{"@type":"Organization","name":"Yale University, School of Medicine, Psychiatry (1991)","@context":"http://schema.org"},{"@type":"Organization","name":"FIDIA-Georgetown Institute for the Neurosciences (1987)","@context":"http://schema.org"},{"@type":"Organization","name":"NIMH-Laboratory of Preclinical Pharmacology (1985)","@context":"http://schema.org"},{"@type":"Organization","name":"Padua University Medical University (1979)","@context":"http://schema.org"}],"sameAs":[],"@context":"http://schema.org"}],"description":"Dai R, Chu T, Zhang M, Wang X, Jourdon A, Wu F, Mariani J, Vaccarino F, Lee D, Fullard J, Hoffman G, Roussos P, Wang Y, Wang X, Pinto D, Wang S, Zhang C, consortium P, Chen C, Liu C. Evaluating performance and applications of sample-wise cell deconvolution methods on human brain transcriptomic data. Science Advances 2024, 10: eadh2588. <a href=\"https://pubmed.ncbi.nlm.nih.gov/38781336\" target=\"_blank\">PMID: 38781336</a>, <a href=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11114236\" target=\"_blank\">PMCID: PMC11114236</a>, <a href=\"https://doi.org/10.1126/sciadv.adh2588\" target=\"_blank\">DOI: 10.1126/sciadv.adh2588</a>.","@context":"http://schema.org"} </script> <script data-schema="MedicalScholarlyArticle" type="application/ld+json"> {"@type":"MedicalScholarlyArticle","publicationType":"Journal Article","inLanguage":"en-US","headline":"Specification of human regional brain lineages using orthogonal gradients of WNT and SHH in organoids.","url":"https://pubmed.ncbi.nlm.nih.gov/38798404","author":[{"@type":"Person","name":"Flora Vaccarino","description":"Flora Vaccarino is the Harris Professor at the Child Study Center and Professor in the Department of Neuroscience at Yale University. She received her MD from the University of Padova in Italy. She spent few years as Neuropharmacology Fellow at NIH, trained in clinical psychiatry at Yale, and then was a Research Fellow in developmental genetics at the Yale School of Medicine, where she raised through the ranks to Assistant, Associate and full Professor. Vaccarino leads a multidisciplinary research group working towards new directions for the study of mammalian brain development, particularly human, using stem cell biology and genomics as tools. She has been studying brain development in animal models for over 20 years, focusing on the role of growth factor receptor signaling in the regulation of stem cell behavior and cerebral cortex morphogenesis. Inspired by Sasai’s work, Vaccarino and her lab pioneered the generation of 3D brain organoids from induced pluripotent stem cells (iPSCs) in 2012, and showed that they recapitulate early fetal development of the human cerebral cortex. They then performed an extensive comparison of the organoid’s transcriptome and noncoding elements with isogenic postmortem human fetal cortex and characterized gene regulatory mechanisms that shape the earliest cell fate decisions in human cortical development. Her lab has generated an extensive collection of patient-derived iPSC lines to study altered gene regulatory mechanisms in Autism Spectrum Disorders. Her interests include human somatic genomic variation as a tool to study lineage specification in human embryonic development. She was one of the fiunding members of the Brain Somatic Mosaicism Network (BSMN), a multi-site consortium that studied somatic mosaicism and its implication for neuropsychiatric diseases. Vaccarino is a Fellow of American Association for the Advancement of Science and a member of the PsychENCODE the Somatic Mosaicism across Human Tissues ( SMaHT) Consortia.","url":"https://medicine.yale.edu/profile/flora-vaccarino/","email":"flora.vaccarino@yale.edu","telephone":"+12037374147","image":{"@type":"ImageObject","url":"https://ysm-res.cloudinary.com/image/upload/c_limit,f_auto,h_630,q_auto,w_1200/v1/yms/prod/35647f85-7587-4df1-8e91-c3a764ccd6cb","description":"2024-09-30-Flora-Vaccarino-","height":1200,"width":630,"@context":"http://schema.org"},"address":[],"workLocation":[],"honorificSuffix":["MD"],"award":[],"jobTitle":["Harris Professor in the Child Study Center"],"affiliation":[{"@type":"Organization","name":"Center for Brain & Mind Health","url":"https://medicine.yale.edu/brain-mind-health/","@context":"http://schema.org"},{"@type":"Organization","name":"Child & Adolescent Psychiatry Training Program","url":"https://medicine.yale.edu/childstudy/education-and-training/clinical-internships-residencies-and-fellowships/child-and-adolescent-psychiatry-fellowship/","@context":"http://schema.org"},{"@type":"Organization","name":"Child Study Center","url":"https://medicine.yale.edu/childstudy/","@context":"http://schema.org"},{"@type":"Organization","name":"Embryonic Stem Cell Research Oversight","@context":"http://schema.org"},{"@type":"Organization","name":"Interdepartmental Neuroscience Program","url":"https://medicine.yale.edu/inp/","@context":"http://schema.org"},{"@type":"Organization","name":"Kavli Institute for Neuroscience","url":"https://medicine.yale.edu/kavli/","@context":"http://schema.org"},{"@type":"Organization","name":"Neuroscience","url":"https://medicine.yale.edu/neuroscience/","@context":"http://schema.org"},{"@type":"Organization","name":"Neuroscience Track","url":"https://medicine.yale.edu/bbs/tracks/neuroscience/","@context":"http://schema.org"},{"@type":"Organization","name":"Program in Neurodevelopment and Regeneration","url":"https://medicine.yale.edu/neurodevelopment/","@context":"http://schema.org"},{"@type":"Organization","name":"Tic Disorder & Obsessive Compulsive Disorder Program","@context":"http://schema.org"},{"@type":"Organization","name":"Vaccarino Lab","url":"https://medicine.yale.edu/lab/vaccarino/","@context":"http://schema.org"},{"@type":"Organization","name":"WHRY Pilot Project Program Investigators","url":"https://medicine.yale.edu/whr/","@context":"http://schema.org"},{"@type":"Organization","name":"Women's Health Research at Yale","url":"https://medicine.yale.edu/whr/","@context":"http://schema.org"},{"@type":"Organization","name":"Wu Tsai Institute","url":"https://wti.yale.edu/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Center for Genomic Health","url":"https://medicine.yale.edu/ycgh/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Combined Program in the Biological and Biomedical Sciences (BBS)","url":"https://medicine.yale.edu/bbs/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Stem Cell Center","url":"https://medicine.yale.edu/stemcell/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Ventures","url":"https://ventures.yale.edu/","@context":"http://schema.org"}],"alumniOf":[{"@type":"Organization","name":"Yale University, School of Medicine, Psychiatry (1991)","@context":"http://schema.org"},{"@type":"Organization","name":"FIDIA-Georgetown Institute for the Neurosciences (1987)","@context":"http://schema.org"},{"@type":"Organization","name":"NIMH-Laboratory of Preclinical Pharmacology (1985)","@context":"http://schema.org"},{"@type":"Organization","name":"Padua University Medical University (1979)","@context":"http://schema.org"}],"sameAs":[],"@context":"http://schema.org"}],"description":"Scuderi S, Kang TY, Jourdon A, Yang L, Wu F, Nelson A, Anderson GM, Mariani J, Sarangi V, Abyzov A, Levchenko A, Vaccarino FM. Specification of human regional brain lineages using orthogonal gradients of WNT and SHH in organoids. BioRxiv 2024 <a href=\"https://pubmed.ncbi.nlm.nih.gov/38798404\" target=\"_blank\">PMID: 38798404</a>, DOI: 10.1101/2024.05.18.594828.","@context":"http://schema.org"} </script> <script type="text/javascript"> (function (c, a) { if (!a.__SV) { var b = window; try { var d, m, j, k = b.location, f = k.hash; d = function (a, b) { return (m = a.match(RegExp(b + "=([^&]*)"))) ? m[1] : null }; f && d(f, "fpState") && (j = JSON.parse(decodeURIComponent(d(f, "fpState"))), "fpeditor" === j.action && (b.sessionStorage.setItem("_fpcehash", f), history.replaceState(j.desiredHash || "", c.title, k.pathname + k.search))) } catch (n) { } var l, h; window.freshpaint = a; a._i = []; a.init = function (b, d, g) { function c(b, i) { var a = i.split("."); 2 == a.length && (b = b[a[0]], i = a[1]); b[i] = function () { b.push([i].concat(Array.prototype.slice.call(arguments, 0))) } } var e = a; "undefined" !== typeof g ? e = a[g] = [] : g = "freshpaint"; e.people = e.people || []; e.toString = function (b) { var a = "freshpaint"; "freshpaint" !== g && (a += "." + g); b || (a += " (stub)"); return a }; e.people.toString = function () { return e.toString(1) + ".people (stub)" }; l = "disable time_event track track_pageview track_links track_forms track_with_groups add_group set_group remove_group register register_once alias unregister identify name_tag set_config reset opt_in_tracking opt_out_tracking has_opted_in_tracking has_opted_out_tracking clear_opt_in_out_tracking people.set people.set_once people.unset people.increment people.append people.union people.track_charge people.clear_charges people.delete_user people.remove people group page alias ready addEventProperties addInitialEventProperties removeEventProperty addPageviewProperties".split(" "); for (h = 0; h < l.length; h++)c(e, l[h]); var f = "set set_once union unset remove delete".split(" "); e.get_group = function () { function a(c) { b[c] = function () { call2_args = arguments; call2 = [c].concat(Array.prototype.slice.call(call2_args, 0)); e.push([d, call2]) } } for (var b = {}, d = ["get_group"].concat(Array.prototype.slice.call(arguments, 0)), c = 0; c < f.length; c++)a(f[c]); return b }; a._i.push([b, d, g]) }; a.__SV = 1.4; b = c.createElement("script"); b.type = "text/javascript"; b.async = !0; b.src = "undefined" !== typeof FRESHPAINT_CUSTOM_LIB_URL ? 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class="profile-details-html-content-section__content"><p>Flora Vaccarino is the Harris Professor at the Child Study Center and Professor in the Department of Neuroscience at Yale University. She received her MD from the University of Padova in Italy. She spent few years as Neuropharmacology Fellow at NIH, trained in clinical psychiatry at Yale, and then was a Research Fellow in developmental genetics at the Yale School of Medicine, where she raised through the ranks to Assistant, Associate and full Professor. Vaccarino leads a multidisciplinary research group working towards new directions for the study of mammalian brain development, particularly human, using stem cell biology and genomics as tools. She has been studying brain development in animal models for over 20 years, focusing on the role of growth factor receptor signaling in the regulation of stem cell behavior and cerebral cortex morphogenesis. Inspired by Sasai’s work, Vaccarino and her lab pioneered the generation of 3D brain organoids from induced pluripotent stem cells (iPSCs) in 2012, and showed that they recapitulate early fetal development of the human cerebral cortex. They then performed an extensive comparison of the organoid’s transcriptome and noncoding elements with isogenic postmortem human fetal cortex and characterized gene regulatory mechanisms that shape the earliest cell fate decisions in human cortical development. Her lab has generated an extensive collection of patient-derived iPSC lines to study altered gene regulatory mechanisms in Autism Spectrum Disorders. Her interests include human somatic genomic variation as a tool to study lineage specification in human embryonic development. She was one of the fiunding members of the Brain Somatic Mosaicism Network (BSMN), a multi-site consortium that studied somatic mosaicism and its implication for neuropsychiatric diseases. Vaccarino is a Fellow of American Association for the Advancement of Science and a member of the PsychENCODE the Somatic Mosaicism across Human Tissues ( SMaHT) Consortia.<br /></p></div></div></section><section class="profile-details-content-section" aria-label="about Appointments" id="about-appointments" tabindex="-1"><h3 class="profile-details-content-section__heading">Appointments</h3><div class="profile-details-content-section__content"><div class="profile-details-appointment-list"><ul class="profile-details-column-list profile-details-column-list--gap-mode--normal profile-details-column-list--gap-mode-on-desktop--normal profile-details-column-list--gap-mode-on-tablet--normal profile-details-column-list--gap-mode-on-mobile--normal profile-details-column-list--columns-on-desktop--2 profile-details-column-list--columns-on-tablet--2 profile-details-column-list--columns-on-mobile--1"><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white profile-details-appointment-card" aria-label="Professor Primary in Child Study Center"><h4 class="profile-details-appointment-card__academic-unit">Child Study Center</h4><div class="profile-details-appointment-card__title">Professor</div><div class="profile-details-appointment-card__type">Primary</div><div class="profile-details-appointment-card__link"><a href="https://medicine.yale.edu/childstudy/" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--blue link--font--bold" aria-label="undefined"><span class="link__label">Child Study Center</span><span class="link__icon" aria-hidden="true"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="profile-details-card-link__icon"><path d="M23.25 12.497H.75M19.5 16.247l3.75-3.75-3.75-3.75" 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class="hyperlink">Child Study Center</a></li><li class="organization-hyperlink-list__item"><span>Embryonic Stem Cell Research Oversight</span></li><li class="organization-hyperlink-list__item"><a href="https://medicine.yale.edu/inp/" tabindex="0" class="hyperlink">Interdepartmental Neuroscience Program</a></li><li class="organization-hyperlink-list__item"><a href="https://medicine.yale.edu/kavli/" tabindex="0" class="hyperlink">Kavli Institute for Neuroscience</a></li><li class="organization-hyperlink-list__item"><a href="https://medicine.yale.edu/neuroscience/" tabindex="0" class="hyperlink">Neuroscience</a></li><li class="organization-hyperlink-list__item"><a href="https://medicine.yale.edu/bbs/tracks/neuroscience/" tabindex="0" class="hyperlink">Neuroscience Track</a></li><li class="organization-hyperlink-list__item"><a href="https://medicine.yale.edu/neurodevelopment/" tabindex="0" class="hyperlink">Program in Neurodevelopment and Regeneration</a></li><li class="organization-hyperlink-list__item"><span>Tic Disorder & Obsessive Compulsive Disorder Program</span></li><li class="organization-hyperlink-list__item"><a href="https://medicine.yale.edu/lab/vaccarino/" tabindex="0" class="hyperlink">Vaccarino Lab</a></li><li class="organization-hyperlink-list__item"><a href="https://medicine.yale.edu/whr/" tabindex="0" class="hyperlink">WHRY Pilot Project Program Investigators</a></li><li class="organization-hyperlink-list__item"><a href="https://medicine.yale.edu/whr/" tabindex="0" class="hyperlink">Women's Health Research at Yale</a></li><li class="organization-hyperlink-list__item"><a href="https://wti.yale.edu/" tabindex="0" class="hyperlink">Wu Tsai Institute</a></li><li class="organization-hyperlink-list__item"><a href="https://medicine.yale.edu/ycgh/" tabindex="0" class="hyperlink">Yale Center for Genomic Health</a></li><li class="organization-hyperlink-list__item"><a href="https://medicine.yale.edu/bbs/" tabindex="0" class="hyperlink">Yale Combined Program in the Biological and Biomedical Sciences (BBS)</a></li><li class="organization-hyperlink-list__item"><a href="https://medicine.yale.edu/stemcell/" tabindex="0" class="hyperlink">Yale Stem Cell Center</a></li><li class="organization-hyperlink-list__item"><a href="https://ventures.yale.edu/" tabindex="0" class="hyperlink">Yale Ventures</a></li></ul></div></div></section><section class="profile-details-content-section" aria-label="about Education & Training" id="about-education-and-training" tabindex="-1"><h3 class="profile-details-content-section__heading">Education & Training</h3><div class="profile-details-content-section__content"><div class="profile-details-education-list"><div class="profile-details-education-list__item"><div class="profile-details-education-list__marker"><svg xmlns="http://www.w3.org/2000/svg" fill="none" viewBox="0 0 11 10" focusable="false" class="profile-details-education-list__marker-icon"><circle cx="5.5" cy="5" r="4" fill="#B4E7F8" stroke="#224570" stroke-width="2"></circle></svg></div><dl class="profile-details-education-list__container"><dt class="profile-details-education-list__degree">Resident</dt><dd class="profile-details-education-list__institution">Yale University, School of Medicine, Psychiatry (1991)</dd></dl></div><div class="profile-details-education-list__item"><div class="profile-details-education-list__marker"><svg xmlns="http://www.w3.org/2000/svg" fill="none" viewBox="0 0 11 10" focusable="false" class="profile-details-education-list__marker-icon"><circle cx="5.5" cy="5" r="4" fill="#B4E7F8" stroke="#224570" stroke-width="2"></circle></svg></div><dl class="profile-details-education-list__container"><dt class="profile-details-education-list__degree">Visiting Assistant Professor</dt><dd class="profile-details-education-list__institution">FIDIA-Georgetown Institute for the Neurosciences (1987)</dd></dl></div><div class="profile-details-education-list__item"><div class="profile-details-education-list__marker"><svg xmlns="http://www.w3.org/2000/svg" fill="none" viewBox="0 0 11 10" focusable="false" class="profile-details-education-list__marker-icon"><circle cx="5.5" cy="5" r="4" fill="#B4E7F8" stroke="#224570" stroke-width="2"></circle></svg></div><dl class="profile-details-education-list__container"><dt class="profile-details-education-list__degree">Research Fellow</dt><dd class="profile-details-education-list__institution">NIMH-Laboratory of Preclinical Pharmacology (1985)</dd></dl></div><div class="profile-details-education-list__item"><div class="profile-details-education-list__marker profile-details-education-list__marker--last"><svg xmlns="http://www.w3.org/2000/svg" fill="none" viewBox="0 0 11 10" focusable="false" class="profile-details-education-list__marker-icon"><circle cx="5.5" cy="5" r="4" fill="#B4E7F8" stroke="#224570" stroke-width="2"></circle></svg></div><dl class="profile-details-education-list__container"><dt class="profile-details-education-list__degree">MD</dt><dd class="profile-details-education-list__institution">Padua University Medical University (1979)</dd></dl></div></div></div></section></div></div><div class="profile-details-section-content__sidebar"><ul class="profile-details-column-list profile-details-column-list--gap-mode--small profile-details-column-list--gap-mode-on-desktop--normal profile-details-column-list--gap-mode-on-tablet--normal profile-details-column-list--gap-mode-on-mobile--small profile-details-column-list--columns-on-desktop--1 profile-details-column-list--columns-on-tablet--1 profile-details-column-list--columns-on-mobile--1"><li class="profile-details-column-list-item"><ul class="profile-details-column-list profile-details-column-list--gap-mode--small profile-details-column-list--gap-mode-on-desktop--normal profile-details-column-list--gap-mode-on-tablet--small profile-details-column-list--gap-mode-on-mobile--small 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class="profile-details-section-content profile-details-research-section__content"><div class="profile-details-section-content__main"><section class="profile-details-content-section" aria-label="research Overview" id="research-overview" tabindex="-1"><h3 class="profile-details-content-section__heading">Overview</h3><div class="profile-details-content-section__content"><div class="profile-details-research-section-overview__description"><p>The Vaccarino laboratory has elucidated crucial mechanisms that regulate neural stem cell self-renewal, survival and differentiation. The lab has been examining conserved mechanisms of forebrain development using mouse models, and human-specific mechanisms by examining human stem and progenitor cells. Using induced pluripotent cells (iPSC) derived from living individuals, the Vaccarino group is now examining how human stem cell differentiation varies across different genetic backgrounds, sex, and clinical phenotypes. </p> <p> In the 1990’s Vaccarino and colleagues reported that an extracellular protein called <strong>Basic Fibroblast Growth Factor 2 (FGF2) </strong>increases the number of progenitors for excitatory cortical neurons in vitro (<a href="https://www.ncbi.nlm.nih.gov/pubmed/7719131">Vaccarino et al., 1995</a>) and in vivo, by microinjection of FGF2 into the cerebral ventricles of rat embryos, producing an increase in cortical surface area (<a href="https://pubmed.ncbi.nlm.nih.gov/10195217/">Vaccarino et al., 1999</a>). This was the first evidence that a single factor can elicit a permanent increase in pyramidal neuron number and cerebral cortical size in a mammalian species. Subsequent work demonstrated that the FGF ligands (Vaccarino et al., 1999; Raballo et al., 2000; Korada et al., 2002) and FGF receptors are essential for normal telencephalic development in a region-specific fashion. The Fgfr1 gene knockout alone thwarts cell proliferation within the hippocampal primordium, causing lifelong hippocampal atrophy (Ohkubo et al., 2004), and the double knockout of Fgfr1 and Fgfr2 causes prefrontal cortex volume loss with fewer pyramidal cells (Stevens et al, 2010). Finally, the combined knockout of Fgfr1, Fgfr2 and Fgfr3 in early neurogenesis depletes the cortical stem cell pool globally, resulting in premature ending of neurogenesis and decreased cortical surface area (<a href="http://www.ncbi.nlm.nih.gov/pubmed/22031906">Rash et al, 2011</a>). Conversely, a microinjection of FGF2 in the lateral ventricles at pre-neurogenic stages of cortical development generates a massive enlargement of frontal cortical surface and the appearance of gyrus-like convolutions in stereotypic bilateral locations (<a href="http://www.ncbi.nlm.nih.gov/pubmed/23804101">Rash et al, 2013</a>). </p> <p>In summary, our studies have shown that FGFs establish the primary structure and the surface area of the cerebral cortex by promoting the self-renewal of neural stem cells and the differentiation of projection neurons from neuroepithelial precursors. </p> <p>The lab has also examined the roles of FGFs in astroglial cells—diverse cellular elements that evolve from a primary role of neural progenitors during embryonic development, to essential partners in neuronal migration, maturation, and metabolic support in the adult brain. To study astroglial cells, the lab has generated the GFAP-CreERT2 transgenic line, in which the Cre recombinase can be transiently induced by a tamoxifen injection in GFAP+ astroglial cells (Ganat et al, 2006). By marking GFAP+ astroglial cells via recombination of genetic reporters, we found that astrocytes can produce neurons in the immature brain, a process that is enhanced by hypoxic injury (Fagel et al., 2006, and Fagel et al, 2009; Bi et al, 2011) and dependent in part upon FGF receptor function (Fagel et al, 2009; Stevens et al, 2102). Furthermore, FGF receptors are required in astroglia to indirectly promote the maturation of cortical inhibitory interneurons during early postnatal development (Müller Smith et al, 2014). Induced loss of FGF signaling only in postnatal astrocytes generates stereotypic locomotor hyperactivity and learning and memory defects that correlate with deficit in specific cell populations in the postnatal brain (Müller Smith et al, 2008, Stevens et al, 2012). </p> <p> Conscious of the profound differences between brain development in rodents and primates, the Vaccarino lab has been pursuing parallel<strong> studies of the human brain</strong>. A major theme is whether an excitatory/inhibitory neuron imbalance in specific forebrain systems due to disparate etiologies (i.e., gene mutations; prenatal factors; environmental noxae) may predispose to neuropsychiatric disorders such as autism and Tourette syndrome. </p> <p>Through <strong>postmortem studies of patient and control brains</strong>, the lab has discovered in landmark studies that individuals with Tourette’s syndrome (TS) have losses of GABAergic and cholinergic interneurons in the striatum. TS is a developmental disorder of childhood characterized by motor and vocal tics. We demonstrated a large decrease in three classes of interneurons in the striatum of TS: Parvalbumin+; NOS+/NPY+/SST+; and cholinergic (<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16131542">Kalanithi et al, 2005</a>; <a href="http://www.ncbi.nlm.nih.gov/pubmed/19941350">Kataoka et al, 2010</a>). RNA sequencing confirmed the decreased in interneuron transcripts, and also revealed an up-regulation of inflammatory response- and immune system-related genes (Lennington et al., 2014). The hypothesis is that altered development of subsets of inhibitory neurons in cortico-basal ganglia circuits causes specific alterations in neuronal firing that may cause disorders of the TS spectrum. Current studies using iPSC-derived basal ganglia organoids confirm thwarted development of inhibitory and cholinergic interneurons in TS and suggest potential pathophysiological mechanisms (see below). </p> <p>To model disorders of brain development in a human system, the Vaccarino lab has adopted the <strong>induced pluripotent stem cell (iPSC)</strong> model and over the last several years has derived over 600 iPSC lines from patients with developmental disorders. Vaccarino and colleagues pioneered the generation of cortical organoids from iPSC lines (Mariani et al, 2012) and contributed fundamental work on neurodevelopmental alterations in severe, idiopathic ASD using this tool. Transcriptome and cell fate studies in organoids from individuals affected with ASD as compared to unaffected family members indicated alterations in cell proliferation, overproduction of synapses and a striking imbalance between inhibitory and excitatory neurons and their precursors (Mariani et al, Cell, 2015). The work has also revealed an important role of the transcription factor FOXG1 in the overproduction of GABAegic precursor cells (<a href="http://www.ncbi.nlm.nih.gov/pubmed/26186191">Mariani et al, 2015</a>). </p> <p>Other studies integrated genomes, transcriptomes and cellular phenotypes to better characterize the organoids as a model for brain development. As part of the <strong><a href="http://psychencode.org/">PsychENCODE</a> collaborative multi-site project, </strong>the lab generated a genome-scale catalog of transcripts and regulatory DNA elements, primarily enhancers, in iPSC-derived organoids and human brain specimens of the same genetic background. The work established that cortical organoids reflect the human cerebral cortex at embryonic to early fetal stages of human brain development, and display a large repertoire of active enhancers that control early neuronal fate and differentiation (<a href="https://pubmed.ncbi.nlm.nih.gov/30545853/">Amiri et al, 2018</a>). </p> <p>Current studies are using single cell approaches to characterize brain organoids in people with different genetic background and in patients with ASD and Tourette syndrome, integrating gene expression with gene regulatory elements and chromatin architecture. </p> <p>In recent years, <strong>somatic mosaicism</strong> has emerged as a potential source of differences in developmental trajectories among individuals. Somatic mosaicism is the accumulation of mutations in cellular genomes after fertilization. These can be variations in DNA sequence, including single nucleotide variations (SNVs) and small insertions/deletions (Indels), or variations in DNA copy number (CNVs), in the form of large duplication/deletions. The notion that cells in an individual organism do not share the same genome is not new, but only in the last decade the scientific community has begun to use emerging deep sequencing technologies to understand the scale of this phenomenon. Somatic mutations are present in both normal cells and in various diseases (Jourdon et al, 2020) and somatic variation has been suggested to play a role in driving neuronal diversity and genome evolution. We collaborate closely with the computational genomics laboratory of Alexej Abyzov at the Mayo Clinic. Together, we have demonstrated and quantified widespread somatic mosaicism in many human cell types and tissues, including human skin fibrolasts (<a href="https://pubmed.ncbi.nlm.nih.gov/23160490/">Abyzov et al, Nature, 2012</a>; <a href="https://genome.cshlp.org/content/early/2017/03/20/gr.215517.116">Abyzov et al, Genome Research, 2017</a>; <a href="http://pubmed.ncbi.nlm.nih.gov/33737484/" title="Fasching et al, Science, 2021">Fasching et al, Science, 2021</a>) and the human developing brain (<a href="https://science.sciencemag.org/content/359/6375/550">Bae et al, Science, 2018</a>). </p> <p>We were founding members of the <strong>Brain Somatic Mosaicism (BSMN) <a href="https://staging.bsmn.synapse.org/">network</a>, </strong>sponsored by the National Institute of Mental Health (NIMH) and encompassing laboratories from several major centers in the US. We are active members of the <strong>Somatic Mosaisism across Human Tissues (SMaHT) </strong>consortium, which aims at generating a catalog of somatic genomic variants in several tissue across the human body and brain.</p> <p>Using postmortem tissue, our group was the first to use retrospective somatic mutations to delineate a lineage map for the early human embryo, which suggested that a mosaic single nucleotide variant (SNV) is generated at each cell division (rate: 1.3 SNVs/cell/mitosis) (<a href="https://science.sciencemag.org/content/359/6375/550">Bae et al, Science, 2018</a>). Since then, we determined that lineage reconstruction can be done in living persons, opening the possibility of using routine lineage reconstruction for understanding individual differences in development, as well as early diagnosis of many medical conditions involving lineage asymmetry and clonal expansion due to MM, including cancer and epilepsy (<a href="http://pubmed.ncbi.nlm.nih.gov/33737484/" title="Fasching et al, Science, 2021">Fasching et al, Science, 2021</a>). </p> <p>Our current work seeks to develop a comprehensive yet minimally invasive approach, including experimental procedures and computational methods, for generating individualized lineage and mosaicism maps. If successful, it could provide a fundamental shift in clinical practice from considering just the individual germline genome to considering the germline genome along with the individual lineage and mosaicism maps and, perhaps, updating these maps over an individual’s lifetime. </p> <p></p></div><section class="profile-details-research-section-overview__keyword-container" aria-label="Medical Research keyword list"><h4 class="profile-details-research-section-overview__keyword-heading">Medical Research Interests</h4><div class="profile-details-research-section-overview__keyword">Autism Spectrum Disorder; Autistic Disorder; Cell Lineage; Central Nervous System Diseases; Developmental Biology; Human Genetics; Induced Pluripotent Stem Cells; Living Donors; Mice, Inbred Strains; Mice, Transgenic; Mosaicism; Neural Stem Cells; Neuroanatomy; Neurodevelopmental Disorders; Neurosciences; Organoids; Patients; Psychiatry and Psychology; Regeneration; Schizophrenia; Tourette Syndrome</div></section></div></section></div><div class="profile-details-section-content__sidebar"><ul class="profile-details-column-list profile-details-column-list--gap-mode--normal profile-details-column-list--gap-mode-on-desktop--normal profile-details-column-list--gap-mode-on-tablet--normal profile-details-column-list--gap-mode-on-mobile--small profile-details-column-list--columns-on-desktop--1 profile-details-column-list--columns-on-tablet--2 profile-details-column-list--columns-on-mobile--1"><li class="profile-details-column-list-item"><section class="profile-details-research-section-orcid" aria-label="Open researcher and contributor id"><h3 class="profile-details-research-section-orcid__heading">ORCID</h3><a href="https://orcid.org/0000-0003-2167-981X/" tabindex="0" class="button button--large button--secondary button--color-mode--blue button--link" target="_blank"><span class="button__label profile-details-research-section-orcid__button-label">0000-0003-2167-981X</span></a></section></li><li class="profile-details-column-list-item"><article class="profile-details-lab" aria-label="Lab Website"><div class="profile-details-lab__header"><svg xmlns="http://www.w3.org/2000/svg" fill="none" viewBox="-0.5 -0.5 20 20" focusable="false" class="profile-details-lab__icon"><desc>Lab Whisk Cup Streamline Icon: https://streamlinehq.com</desc><path stroke="currentColor" stroke-linecap="round" stroke-linejoin="round" d="M11.265 5.146H3.776a.4.4 0 0 0-.356.221.4.4 0 0 0 .047.42l.895 1.116a.8.8 0 0 1 .174.5v9.618a1.583 1.583 0 0 0 1.584 1.583h7.916a1.583 1.583 0 0 0 1.584-1.583V5.54a.396.396 0 0 0-.396-.395h-.792"></path><path stroke="currentColor" stroke-linecap="round" stroke-linejoin="round" d="M10.672 17.02a1.385 1.385 0 1 0 0-2.77 1.385 1.385 0 0 0 0 2.77M11.075 14.313 13.64.396M4.536 11.875h5.146M11.519 11.875h4.1M4.536 9.5H6.12M4.536 16.625H6.12M4.536 14.25H6.12"></path><g stroke="currentColor"><path d="M9.848.99a.198.198 0 1 1 0-.396M9.848.99a.198.198 0 1 0 0-.396"></path></g><g stroke="currentColor"><path d="M8.265 3.365a.198.198 0 1 1 0-.396M8.265 3.365a.198.198 0 1 0 0-.396"></path></g><g stroke="currentColor"><path d="M10.094 7.125a.198.198 0 1 1 0-.396M10.094 7.125a.198.198 0 1 0 0-.396"></path></g><g stroke="currentColor"><path d="M8.89 9.698a.198.198 0 1 1 0-.396M8.89 9.698a.198.198 0 1 0 0-.396"></path></g></svg><h3 class="profile-details-lab__title">Vaccarino Lab</h3></div><a href="https://medicine.yale.edu/lab/vaccarino/" tabindex="0" class="button button--large button--secondary button--color-mode--blue button--link"><span class="button__label">View Lab Website</span></a></article></li></ul></div></div><div class="profile-details-section-content profile-details-section-content--without-sidebar profile-details-research-section__content profile-details-research-section__glance-content"><div class="profile-details-section-content__main"><section class="profile-details-content-section" aria-label="research Research at a Glance" id="research-research-at-a-glance" tabindex="-1"><h3 class="profile-details-content-section__heading">Research at a Glance</h3><div class="profile-details-content-section__content"><div class="profile-details-glance-list"><div class="profile-details-glance-list__description-column"><div class="slick-slider slick-initialized" dir="ltr"><div class="slick-list"><div class="slick-track" style="width:700%;left:-100%"><div data-index="0" class="slick-slide slick-active slick-current" tabindex="-1" aria-hidden="false" style="outline:none;width:14.285714285714286%;position:relative;left:0;opacity:1;z-index:999;transition:opacity 250ms ease, visibility 250ms ease"><div><div class="profile-details-glance-description"><h4 class="profile-details-glance-description__heading">Yale Co-Authors</h4><div class="profile-details-glance-description__content">Frequent collaborators of Flora Vaccarino's published research.</div></div></div></div><div data-index="1" class="slick-slide" tabindex="-1" aria-hidden="true" style="outline:none;width:14.285714285714286%;position:relative;left:-14px;opacity:0;z-index:998;transition:opacity 250ms ease, visibility 250ms ease"><div><div class="profile-details-glance-description"><h4 class="profile-details-glance-description__heading">Publications Timeline</h4><div class="profile-details-glance-description__content">A big-picture view of Flora Vaccarino's research output by year.</div></div></div></div><div data-index="2" class="slick-slide" tabindex="-1" aria-hidden="true" style="outline:none;width:14.285714285714286%;position:relative;left:-28px;opacity:0;z-index:998;transition:opacity 250ms ease, visibility 250ms ease"><div><div class="profile-details-glance-description"><h4 class="profile-details-glance-description__heading">Research Interests</h4><div class="profile-details-glance-description__content">Research topics Flora Vaccarino is interested in exploring.</div></div></div></div></div></div></div><div class="profile-details-glance-list__navigation"><div class="profile-details-slider-navigation profile-details-slider-navigation--color-mode--dark"><button class="profile-details-slider-navigation__arrow-button" type="button" aria-label="Go to slide Research Interests"><span class="slider-navigation__icon"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="profile-details-slider-navigation__arrow-button-icon"><path d="M.757 12h22.486M12.743 1 1.1 11.249a1 1 0 0 0 0 1.5L12.743 23" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round"></path></svg></span></button><div class="profile-details-slider-navigation__dot-button-container"><button type="button" class="profile-details-slider-navigation__dot-button profile-details-slider-navigation__dot-button--active" aria-label="Go to slide Yale Co-Authors" aria-current="true"></button><button type="button" 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data-index="0" class="slick-slide slick-active slick-current" tabindex="-1" aria-hidden="false" style="outline:none;width:14.285714285714286%;position:relative;left:0;opacity:1;z-index:999;transition:opacity 250ms ease, visibility 250ms ease"><div><div tabindex="-1" style="width:100%;display:inline-block"><section class="profile-details-coauthors-glance" aria-label="Paged coauthors list"><div class="profile-details-coauthors-glance__content"><ul class="profile-details-column-list profile-details-column-list--gap-mode--normal profile-details-column-list--gap-mode-on-desktop--normal profile-details-column-list--gap-mode-on-tablet--normal profile-details-column-list--gap-mode-on-mobile--normal profile-details-column-list--columns-on-desktop--2 profile-details-column-list--columns-on-tablet--2 profile-details-column-list--columns-on-mobile--1"><li class="profile-details-column-list-item"><article class="profile-details-coauthor" aria-label="Co-author Alexej Abyzov, PhD"><div style="width:100px;height:100px" class="profile-details-glance-figure"><div style="width:100px;height:100px" class="profile-details-glance-figure__entry profile-details-glance-figure__entry--round"></div></div><h5 class="profile-details-coauthor__name">Alexej Abyzov, PhD</h5><div class="profile-details-coauthor__profile-link-wrapper"><a href="/childstudy/profile/alexej-abyzov/" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--navy link--font--normal link--with-custom-icon-color" aria-label="Go to Alexej Abyzov, PhD's details page"><span class="link__label">View Full Profile</span><span class="link__icon link__icon--color--blue" aria-hidden="true"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="profile-details-coauthor__profile-link-icon"><path d="M23.25 12.497H.75M19.5 16.247l3.75-3.75-3.75-3.75" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg></span></a></div><div class="profile-details-coauthor__publication-link-wrapper"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&profilePageName=alexej-abyzov" tabindex="0" class="hyperlink profile-details-coauthor__publication-link" aria-label="Go to publications search page to find all common items between Alexej Abyzov, PhD and Flora Vaccarino">View 24 Common Publications</a></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-coauthor" aria-label="Co-author Michael Schwartz, PhD"><div style="width:100px;height:100px" class="profile-details-glance-figure"><div style="width:96px;height:96px" class="profile-details-glance-figure__entry profile-details-glance-figure__entry--round"></div></div><h5 class="profile-details-coauthor__name">Michael Schwartz, PhD</h5><div class="profile-details-coauthor__profile-link-wrapper"><a href="https://medicine.yale.edu/profile/michael-schwartz/" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--navy link--font--normal link--with-custom-icon-color" aria-label="Go to Michael Schwartz, PhD's details page"><span class="link__label">View Full Profile</span><span class="link__icon link__icon--color--blue" aria-hidden="true"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="profile-details-coauthor__profile-link-icon"><path d="M23.25 12.497H.75M19.5 16.247l3.75-3.75-3.75-3.75" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg></span></a></div><div class="profile-details-coauthor__publication-link-wrapper"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&profilePageName=michael-schwartz" tabindex="0" class="hyperlink profile-details-coauthor__publication-link" aria-label="Go to publications search page to find all common items between Michael Schwartz, PhD and Flora Vaccarino">View 23 Common Publications</a></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-coauthor" aria-label="Co-author Jessica Mariani, PhD"><div style="width:100px;height:100px" class="profile-details-glance-figure"><div style="width:63px;height:63px" class="profile-details-glance-figure__entry profile-details-glance-figure__entry--round"></div></div><h5 class="profile-details-coauthor__name">Jessica Mariani, PhD</h5><div class="profile-details-coauthor__profile-link-wrapper"><a href="https://medicine.yale.edu/profile/jessica-mariani/" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--navy link--font--normal link--with-custom-icon-color" aria-label="Go to Jessica Mariani, PhD's details page"><span class="link__label">View Full Profile</span><span class="link__icon link__icon--color--blue" aria-hidden="true"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="profile-details-coauthor__profile-link-icon"><path d="M23.25 12.497H.75M19.5 16.247l3.75-3.75-3.75-3.75" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg></span></a></div><div class="profile-details-coauthor__publication-link-wrapper"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&profilePageName=jessica-mariani" tabindex="0" class="hyperlink profile-details-coauthor__publication-link" aria-label="Go to publications search page to find all common items between Jessica Mariani, PhD and Flora Vaccarino">View 15 Common Publications</a></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-coauthor" aria-label="Co-author Livia Tomasini"><div style="width:100px;height:100px" class="profile-details-glance-figure"><div style="width:58px;height:58px" class="profile-details-glance-figure__entry profile-details-glance-figure__entry--round"></div></div><h5 class="profile-details-coauthor__name">Livia Tomasini</h5><div class="profile-details-coauthor__profile-link-wrapper"><a href="/childstudy/profile/livia-tomasini/" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--navy link--font--normal link--with-custom-icon-color" aria-label="Go to Livia Tomasini's details page"><span class="link__label">View Full Profile</span><span class="link__icon link__icon--color--blue" aria-hidden="true"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="profile-details-coauthor__profile-link-icon"><path d="M23.25 12.497H.75M19.5 16.247l3.75-3.75-3.75-3.75" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg></span></a></div><div class="profile-details-coauthor__publication-link-wrapper"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&profilePageName=livia-tomasini" tabindex="0" class="hyperlink profile-details-coauthor__publication-link" aria-label="Go to publications search page to find all common items between Livia Tomasini and Flora Vaccarino">View 14 Common Publications</a></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-coauthor" aria-label="Co-author Anna Szekely, MD"><div style="width:100px;height:100px" class="profile-details-glance-figure"><div style="width:54px;height:54px" class="profile-details-glance-figure__entry profile-details-glance-figure__entry--round"></div></div><h5 class="profile-details-coauthor__name">Anna Szekely, MD</h5><div class="profile-details-coauthor__profile-link-wrapper"><a href="https://medicine.yale.edu/profile/anna-szekely/" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--navy link--font--normal link--with-custom-icon-color" aria-label="Go to Anna Szekely, MD's details page"><span class="link__label">View Full Profile</span><span class="link__icon link__icon--color--blue" aria-hidden="true"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="profile-details-coauthor__profile-link-icon"><path d="M23.25 12.497H.75M19.5 16.247l3.75-3.75-3.75-3.75" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg></span></a></div><div class="profile-details-coauthor__publication-link-wrapper"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&profilePageName=anna-szekely" tabindex="0" class="hyperlink profile-details-coauthor__publication-link" aria-label="Go to publications search page to find all common items between Anna Szekely, MD and Flora Vaccarino">View 13 Common Publications</a></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-coauthor" aria-label="Co-author Gianfilippo Coppola, PhD"><div style="width:100px;height:100px" class="profile-details-glance-figure"><div style="width:46px;height:46px" class="profile-details-glance-figure__entry profile-details-glance-figure__entry--round"></div></div><h5 class="profile-details-coauthor__name">Gianfilippo Coppola, PhD</h5><div class="profile-details-coauthor__profile-link-wrapper"><a href="https://medicine.yale.edu/profile/gianfilippo-coppola/" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--navy link--font--normal link--with-custom-icon-color" aria-label="Go to Gianfilippo Coppola, PhD's details page"><span class="link__label">View Full Profile</span><span class="link__icon link__icon--color--blue" aria-hidden="true"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="profile-details-coauthor__profile-link-icon"><path d="M23.25 12.497H.75M19.5 16.247l3.75-3.75-3.75-3.75" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg></span></a></div><div class="profile-details-coauthor__publication-link-wrapper"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&profilePageName=gianfilippo-coppola" tabindex="0" class="hyperlink profile-details-coauthor__publication-link" aria-label="Go to publications search page to find all common items between Gianfilippo Coppola, PhD and Flora Vaccarino">View 11 Common Publications</a></div></article></li></ul></div><div class="profile-details-coauthors-glance__pagination"></div></section></div></div></div><div data-index="1" class="slick-slide" tabindex="-1" aria-hidden="true" style="outline:none;width:14.285714285714286%;position:relative;left:-14px;opacity:0;z-index:998;transition:opacity 250ms ease, visibility 250ms ease"><div><div tabindex="-1" style="width:100%;display:inline-block"><section class="profile-details-publications-timeline-glance" aria-label="Publications timeline chart"><div class="profile-details-publications-timeline-glance__stats"><div class="profile-details-publications-timeline-info"><span class="profile-details-publications-timeline-info__count">169</span><span class="profile-details-publications-timeline-info__title">Publications</span></div><div class="profile-details-publications-timeline-info"><span class="profile-details-publications-timeline-info__count">10,304</span><span class="profile-details-publications-timeline-info__title">Citations</span></div></div><div class="profile-details-publications-timeline-glance__chart"><canvas role="img" height="150" width="300" aria-label="Publications by Year chart"></canvas></div></section></div></div></div><div data-index="2" class="slick-slide" tabindex="-1" aria-hidden="true" style="outline:none;width:14.285714285714286%;position:relative;left:-28px;opacity:0;z-index:998;transition:opacity 250ms ease, visibility 250ms ease"><div><div tabindex="-1" style="width:100%;display:inline-block"><section class="profile-details-interests-glance" aria-label="Paged research interests list"><div class="profile-details-interests-glance__content"><ul class="profile-details-column-list profile-details-column-list--gap-mode--normal profile-details-column-list--gap-mode-on-desktop--normal profile-details-column-list--gap-mode-on-tablet--normal profile-details-column-list--gap-mode-on-mobile--normal profile-details-column-list--columns-on-desktop--2 profile-details-column-list--columns-on-tablet--2 profile-details-column-list--columns-on-mobile--1"><li class="profile-details-column-list-item"><article class="profile-details-interest" aria-label="Research Interest Mice, Transgenic"><div style="width:100px;height:100px" class="profile-details-glance-figure"><div style="width:100px;height:100px" class="profile-details-glance-figure__entry"></div></div><h5 class="profile-details-interest__keyword">Mice, Transgenic</h5><div class="profile-details-interest__researcher-link-wrapper"><a href="/childstudy/research-profiles/?orgId=108736&meshId=8430" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--navy link--font--normal link--with-custom-icon-color" aria-label="Go to Mice, Transgenic Researchers"><span class="link__label"> Researcher</span><span class="link__icon link__icon--color--blue" aria-hidden="true"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="profile-details-interest__researcher-link-icon"><path d="M23.25 12.497H.75M19.5 16.247l3.75-3.75-3.75-3.75" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg></span></a></div><div class="profile-details-interest__publication-link-wrapper"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=8430" tabindex="0" class="hyperlink profile-details-interest__publication-link" aria-label="Go to publications search page to find all items related to Mice, Transgenic">View 17 Related Publications</a></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-interest" aria-label="Research Interest Induced Pluripotent Stem Cells"><div style="width:100px;height:100px" class="profile-details-glance-figure"><div style="width:94px;height:94px" class="profile-details-glance-figure__entry"></div></div><h5 class="profile-details-interest__keyword">Induced Pluripotent Stem Cells</h5><div class="profile-details-interest__researcher-link-wrapper"><a href="/childstudy/research-profiles/?orgId=108736&meshId=25380" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--navy link--font--normal link--with-custom-icon-color" aria-label="Go to Induced Pluripotent Stem Cells Researchers"><span class="link__label">2 Researchers</span><span class="link__icon link__icon--color--blue" aria-hidden="true"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="profile-details-interest__researcher-link-icon"><path d="M23.25 12.497H.75M19.5 16.247l3.75-3.75-3.75-3.75" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg></span></a></div><div class="profile-details-interest__publication-link-wrapper"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=25380" tabindex="0" class="hyperlink profile-details-interest__publication-link" aria-label="Go to publications search page to find all items related to Induced Pluripotent Stem Cells">View 16 Related Publications</a></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-interest" aria-label="Research Interest Cell Lineage"><div style="width:100px;height:100px" class="profile-details-glance-figure"><div style="width:76px;height:76px" class="profile-details-glance-figure__entry"></div></div><h5 class="profile-details-interest__keyword">Cell Lineage</h5><div class="profile-details-interest__researcher-link-wrapper"><a href="/childstudy/research-profiles/?orgId=108736&meshId=17738" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--navy link--font--normal link--with-custom-icon-color" aria-label="Go to Cell Lineage Researchers"><span class="link__label"> Researcher</span><span class="link__icon link__icon--color--blue" aria-hidden="true"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="profile-details-interest__researcher-link-icon"><path d="M23.25 12.497H.75M19.5 16.247l3.75-3.75-3.75-3.75" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg></span></a></div><div class="profile-details-interest__publication-link-wrapper"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=17738" tabindex="0" class="hyperlink profile-details-interest__publication-link" aria-label="Go to publications search page to find all items related to Cell Lineage">View 13 Related Publications</a></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-interest" aria-label="Research Interest Organoids"><div style="width:100px;height:100px" class="profile-details-glance-figure"><div style="width:65px;height:65px" class="profile-details-glance-figure__entry"></div></div><h5 class="profile-details-interest__keyword">Organoids</h5><div class="profile-details-interest__researcher-link-wrapper"><a href="/childstudy/research-profiles/?orgId=108736&meshId=9503" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--navy link--font--normal link--with-custom-icon-color" aria-label="Go to Organoids Researchers"><span class="link__label">2 Researchers</span><span class="link__icon link__icon--color--blue" aria-hidden="true"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="profile-details-interest__researcher-link-icon"><path d="M23.25 12.497H.75M19.5 16.247l3.75-3.75-3.75-3.75" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg></span></a></div><div class="profile-details-interest__publication-link-wrapper"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=9503" tabindex="0" class="hyperlink profile-details-interest__publication-link" aria-label="Go to publications search page to find all items related to Organoids">View 11 Related Publications</a></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-interest" aria-label="Research Interest Mosaicism"><div style="width:100px;height:100px" class="profile-details-glance-figure"><div style="width:53px;height:53px" class="profile-details-glance-figure__entry"></div></div><h5 class="profile-details-interest__keyword">Mosaicism</h5><div class="profile-details-interest__researcher-link-wrapper"><a href="/childstudy/research-profiles/?orgId=108736&meshId=8628" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--navy link--font--normal link--with-custom-icon-color" aria-label="Go to Mosaicism Researchers"><span class="link__label"> Researcher</span><span class="link__icon link__icon--color--blue" aria-hidden="true"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="profile-details-interest__researcher-link-icon"><path d="M23.25 12.497H.75M19.5 16.247l3.75-3.75-3.75-3.75" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg></span></a></div><div class="profile-details-interest__publication-link-wrapper"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=8628" tabindex="0" class="hyperlink profile-details-interest__publication-link" aria-label="Go to publications search page to find all items related to Mosaicism">View 9 Related Publications</a></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-interest" aria-label="Research Interest Autistic Disorder"><div style="width:100px;height:100px" class="profile-details-glance-figure"><div style="width:35px;height:35px" class="profile-details-glance-figure__entry"></div></div><h5 class="profile-details-interest__keyword">Autistic Disorder</h5><div class="profile-details-interest__researcher-link-wrapper"><a href="/childstudy/research-profiles/?orgId=108736&meshId=1255" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--navy link--font--normal link--with-custom-icon-color" aria-label="Go to Autistic Disorder Researchers"><span class="link__label">13 Researchers</span><span class="link__icon link__icon--color--blue" aria-hidden="true"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="profile-details-interest__researcher-link-icon"><path d="M23.25 12.497H.75M19.5 16.247l3.75-3.75-3.75-3.75" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg></span></a></div><div class="profile-details-interest__publication-link-wrapper"><a 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1 0 0 0 0-1.5L11.257 1" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round"></path></svg></button></div></div></div></div></div></section></div></div><div class="profile-details-section-content profile-details-section-content--with-empty-sidebar profile-details-research-section__content"><div class="profile-details-section-content__main"><section class="profile-details-content-section" aria-label="research Publications" id="research-publications" tabindex="-1"><h3 class="profile-details-content-section__heading">Publications</h3><div class="profile-details-content-section__content"><section class="profile-publication-card-grouped-list__section" aria-label="2025 Group"><h4 class="profile-publication-card-grouped-list__section-title">2025</h4><ul class="profile-details-column-list profile-details-column-list--gap-mode--small profile-details-column-list--gap-mode-on-desktop--small profile-details-column-list--gap-mode-on-tablet--small profile-details-column-list--gap-mode-on-mobile--small profile-details-column-list--columns-on-desktop--1 profile-details-column-list--columns-on-tablet--1 profile-details-column-list--columns-on-mobile--1"><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white profile-publication-card" aria-label="Interneuron loss and microglia activation by transcriptome analyses in the basal ganglia of Tourette disorder."><div class="profile-publication-card__content-container"><div class="profile-publication-card__content"><h5 class="profile-publication-card__title"><a href="https://pubmed.ncbi.nlm.nih.gov/39892689" class="profile-publication-card__link">Interneuron loss and microglia activation by transcriptome analyses in the basal ganglia of Tourette disorder.</a></h5><cite class="profile-publication-card__citation">Wang Y, Fasching L, Wu F, Suvakov M, Huttner A, Berretta S, Roberts R, Leckman JF, Fernandez TV, Abyzov A, Vaccarino FM. Interneuron loss and microglia activation by transcriptome analyses in the basal ganglia of Tourette disorder. Biol Psychiatry 2025 <a href="https://pubmed.ncbi.nlm.nih.gov/39892689" target="_blank">PMID: 39892689</a>, DOI: 10.1016/j.biopsych.2024.12.022.</cite><div class="profile-publication-card__category">Peer-Reviewed Original Research</div></div></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white profile-publication-card" aria-label="Chapter 53 Tourette syndrome"><div class="profile-publication-card__content-container"><div class="profile-publication-card__content"><h5 class="profile-publication-card__title"><a href="https://doi.org/10.1016/b978-0-443-19176-3.00044-3" class="profile-publication-card__link">Chapter 53 Tourette syndrome</a></h5><cite class="profile-publication-card__citation">Abdallah S, Fasching L, Brady M, Bloch M, Lombroso P, Vaccarino F, Fernandez T. Chapter 53 Tourette syndrome. 2025, 951-962. <a href="https://doi.org/10.1016/b978-0-443-19176-3.00044-3" target="_blank">DOI: 10.1016/b978-0-443-19176-3.00044-3</a>.</cite><div class="profile-publication-card__category">Chapters</div></div></div><div class="profile-publication-card__keyword-accordion"><div data-accordion-component="Accordion" class="accordion"><div data-accordion-component="AccordionItem" class="accordion__item"><div data-accordion-component="AccordionItemHeading" aria-level="6" role="heading" class="accordion__heading"><div class="profile-accordion-item-button profile-accordion-item-button--color-mode--navy profile-accordion-item-button--thickness-mode--bold profile-accordion-item-button--text-size-mode--default profile-accordion-item-button--content-alignment-mode--default" id="accordion__heading-raa-0" aria-disabled="false" aria-expanded="false" aria-controls="accordion__panel-raa-0" role="button" tabindex="0" data-accordion-component="AccordionItemButton"><span class="profile-accordion-item-button__label">Concepts</span><span class="animated-expand-icon"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="animated-expand-icon__icon"><path d="M12 1v22M23 12H1" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round"></path></svg></span></div></div><div data-accordion-component="AccordionItemPanel" class="accordion__panel" id="accordion__panel-raa-0" hidden=""><div class="profile-publication-card-keyword-accordion__container"><div class="profile-publication-card-keyword-list"><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Tourette%20syndrome" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Tourette syndrome</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Cortico-striatal-thalamo-cortical%20circuitry" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Cortico-striatal-thalamo-cortical circuitry</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Striatal%20volume%20loss" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Striatal volume loss</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Adult%20TS%20patients" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Adult TS patients</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Neuroimaging%20studies" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Neuroimaging studies</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Neuropsychiatric%20disorders" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Neuropsychiatric disorders</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Dopaminergic%20receptors" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Dopaminergic receptors</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Vocal%20tics" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Vocal tics</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Striatal%20interneurons" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Striatal interneurons</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Classes%20of%20striatal%20interneurons" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Classes of striatal interneurons</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Basal%20ganglia" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Basal ganglia</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Metabolic%20hypofunction" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Metabolic hypofunction</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Environmental%20risk%20factors" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Environmental risk factors</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=TS%20patients" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">TS patients</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Ameliorate%20symptoms" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Ameliorate symptoms</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Genetic%20contribution" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Genetic contribution</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Molecular%20abnormalities" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Molecular abnormalities</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Pharmacological%20strategies" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Pharmacological strategies</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Circuitry" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Circuitry</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Affecting%201" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Affecting 1</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Animal%20models" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Animal models</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Risk%20factors" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Risk factors</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Interneuronal%20circuitry" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Interneuronal circuitry</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Volume%20loss" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Volume loss</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Abnormalities" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Abnormalities</span></a></span></div></div></div></div></div></div></article></li></ul></section><section class="profile-publication-card-grouped-list__section" aria-label="2024 Group"><h4 class="profile-publication-card-grouped-list__section-title">2024</h4><ul class="profile-details-column-list profile-details-column-list--gap-mode--small profile-details-column-list--gap-mode-on-desktop--small profile-details-column-list--gap-mode-on-tablet--small profile-details-column-list--gap-mode-on-mobile--small profile-details-column-list--columns-on-desktop--1 profile-details-column-list--columns-on-tablet--1 profile-details-column-list--columns-on-mobile--1"><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white profile-publication-card" aria-label="A framework for neural organoids, assembloids and transplantation studies"><div class="profile-publication-card__content-container"><div class="profile-publication-card__content"><h5 class="profile-publication-card__title"><a href="https://pubmed.ncbi.nlm.nih.gov/39653126" class="profile-publication-card__link">A framework for neural organoids, assembloids and transplantation studies</a></h5><cite class="profile-publication-card__citation">Pașca S, Arlotta P, Bateup H, Camp J, Cappello S, Gage F, Knoblich J, Kriegstein A, Lancaster M, Ming G, Novarino G, Okano H, Parmar M, Park I, Reiner O, Song H, Studer L, Takahashi J, Temple S, Testa G, Treutlein B, Vaccarino F, Vanderhaeghen P, Young-Pearse T. A framework for neural organoids, assembloids and transplantation studies. Nature 2024, 1-3. <a href="https://pubmed.ncbi.nlm.nih.gov/39653126" target="_blank">PMID: 39653126</a>, <a href="https://doi.org/10.1038/s41586-024-08487-6" target="_blank">DOI: 10.1038/s41586-024-08487-6</a>.</cite><div class="profile-publication-card__category">Peer-Reviewed Original Research</div></div><div class="profile-publication-card__badge-container" aria-hidden="true"><div class="profile-publication-card__badge"><div class="profile-publication-card__badge-label">Altmetric</div></div></div></div><div class="profile-publication-card__keyword-accordion"><div data-accordion-component="Accordion" class="accordion"><div data-accordion-component="AccordionItem" class="accordion__item"><div data-accordion-component="AccordionItemHeading" aria-level="6" role="heading" class="accordion__heading"><div class="profile-accordion-item-button profile-accordion-item-button--color-mode--navy profile-accordion-item-button--thickness-mode--bold profile-accordion-item-button--text-size-mode--default profile-accordion-item-button--content-alignment-mode--default" id="accordion__heading-raa-1" aria-disabled="false" aria-expanded="false" aria-controls="accordion__panel-raa-1" role="button" tabindex="0" data-accordion-component="AccordionItemButton"><span class="profile-accordion-item-button__label">Concepts</span><span class="animated-expand-icon"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="animated-expand-icon__icon"><path d="M12 1v22M23 12H1" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round"></path></svg></span></div></div><div data-accordion-component="AccordionItemPanel" class="accordion__panel" id="accordion__panel-raa-1" hidden=""><div class="profile-publication-card-keyword-accordion__container"><div class="profile-publication-card-keyword-list"><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Data%20sharing" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Data sharing</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Cells%20in%20vitro" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Cells in vitro</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Human%20pluripotent%20stem%20cells" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Human pluripotent stem cells</span></a></span></div></div></div></div></div></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white profile-publication-card" aria-label="Transgenerational transmission of post-zygotic mutations suggests symmetric contribution of first two blastomeres to human germline"><div class="profile-publication-card__content-container"><div class="profile-publication-card__content"><h5 class="profile-publication-card__title"><a href="https://pubmed.ncbi.nlm.nih.gov/39438473" class="profile-publication-card__link">Transgenerational transmission of post-zygotic mutations suggests symmetric contribution of first two blastomeres to human germline</a></h5><cite class="profile-publication-card__citation">Jang Y, Tomasini L, Bae T, Szekely A, Vaccarino F, Abyzov A. Transgenerational transmission of post-zygotic mutations suggests symmetric contribution of first two blastomeres to human germline. Nature Communications 2024, 15: 9117. <a href="https://pubmed.ncbi.nlm.nih.gov/39438473" target="_blank">PMID: 39438473</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11496613" target="_blank">PMCID: PMC11496613</a>, <a href="https://doi.org/10.1038/s41467-024-53485-x" target="_blank">DOI: 10.1038/s41467-024-53485-x</a>.</cite><div class="profile-publication-card__category">Peer-Reviewed Original Research</div></div><div class="profile-publication-card__badge-container" aria-hidden="true"><div class="profile-publication-card__badge"><div class="profile-publication-card__badge-label">Altmetric</div></div></div></div><div class="profile-publication-card__keyword-accordion"><div data-accordion-component="Accordion" class="accordion"><div data-accordion-component="AccordionItem" class="accordion__item"><div data-accordion-component="AccordionItemHeading" aria-level="6" role="heading" class="accordion__heading"><div class="profile-accordion-item-button profile-accordion-item-button--color-mode--navy profile-accordion-item-button--thickness-mode--bold profile-accordion-item-button--text-size-mode--default profile-accordion-item-button--content-alignment-mode--default" id="accordion__heading-raa-2" aria-disabled="false" aria-expanded="false" aria-controls="accordion__panel-raa-2" role="button" tabindex="0" data-accordion-component="AccordionItemButton"><span class="profile-accordion-item-button__label">MeSH Keywords and Concepts</span><span class="animated-expand-icon"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="animated-expand-icon__icon"><path d="M12 1v22M23 12H1" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round"></path></svg></span></div></div><div data-accordion-component="AccordionItemPanel" class="accordion__panel" id="accordion__panel-raa-2" hidden=""><div class="profile-publication-card-keyword-accordion__container"><div class="profile-publication-card-keyword-list"><span class="profile-publication-card-keyword-list__keyword-label">MeSH Keywords</span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=311" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Adult</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=1671" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Blastomeres</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=17738" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Cell Lineage</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=5033" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Female</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=5603" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Germ Cells</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=16893" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Germ-Line Mutation</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=6498" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Humans</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=7926" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Male</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=8746" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Mutation</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=9923" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Pedigree</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=14428" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Zygote</span></a></span></div></div><div class="profile-publication-card-keyword-accordion__container"><div class="profile-publication-card-keyword-list"><span class="profile-publication-card-keyword-list__keyword-label">Concepts</span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Post-zygotic%20mutations" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Post-zygotic mutations</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Lineage%20allocation" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Lineage allocation</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Origin%20of%20germ%20cells" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Origin of germ cells</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Phenotypically%20normal%20woman" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Phenotypically normal woman</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Germ%20cells" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Germ cells</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Somatic%20tissues" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Somatic tissues</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Human%20germline" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Human germline</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Lineages" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Lineages</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Mutation%20transmission" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Mutation transmission</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Germline" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Germline</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Normal%20women" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Normal women</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Mutations" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Mutations</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Zygotic%20cleavage" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Zygotic cleavage</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Blastomeres" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Blastomeres</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Genome" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Genome</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Cells" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Cells</span></a></span></div></div></div></div></div></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white profile-publication-card" aria-label="Tourette syndrome"><div class="profile-publication-card__content-container"><div class="profile-publication-card__content"><h5 class="profile-publication-card__title"><span>Tourette syndrome</span></h5><cite class="profile-publication-card__citation">Abdallah SB, Fasching L, Brady M, Bloch MH, Lombroso P, Vaccarino FM, Fernandez TV. Tourette syndrome. In: Rosenberg RN, Pascual JM, editors. Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease, Seventh Edition San Diego, CA: Elsevier/Academic Press; 2024. Chapter 53; p.951-962. </cite><div class="profile-publication-card__category">Chapters</div></div></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white profile-publication-card" aria-label="Elevated antibody binding to striatal cholinergic interneurons in patients with pediatric acute-onset neuropsychiatric syndrome"><div class="profile-publication-card__content-container"><div class="profile-publication-card__content"><h5 class="profile-publication-card__title"><a href="https://pubmed.ncbi.nlm.nih.gov/39084540" class="profile-publication-card__link">Elevated antibody binding to striatal cholinergic interneurons in patients with pediatric acute-onset neuropsychiatric syndrome</a></h5><cite class="profile-publication-card__citation">Xu J, Frankovich J, Liu R, Thienemann M, Silverman M, Farhadian B, Willett T, Manko C, Columbo L, Leibold C, Vaccarino F, Che A, Pittenger C. Elevated antibody binding to striatal cholinergic interneurons in patients with pediatric acute-onset neuropsychiatric syndrome. Brain Behavior And Immunity 2024, 122: 241-255. <a href="https://pubmed.ncbi.nlm.nih.gov/39084540" target="_blank">PMID: 39084540</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11569416" target="_blank">PMCID: PMC11569416</a>, <a href="https://doi.org/10.1016/j.bbi.2024.07.044" target="_blank">DOI: 10.1016/j.bbi.2024.07.044</a>.</cite><div class="profile-publication-card__category">Peer-Reviewed Original Research</div></div><div class="profile-publication-card__badge-container" aria-hidden="true"><div class="profile-publication-card__badge"><div class="profile-publication-card__badge-label">Citations</div></div><div class="profile-publication-card__badge"><div class="profile-publication-card__badge-label">Altmetric</div></div></div></div><div class="profile-publication-card__keyword-accordion"><div data-accordion-component="Accordion" class="accordion"><div data-accordion-component="AccordionItem" class="accordion__item"><div data-accordion-component="AccordionItemHeading" aria-level="6" role="heading" class="accordion__heading"><div class="profile-accordion-item-button profile-accordion-item-button--color-mode--navy profile-accordion-item-button--thickness-mode--bold profile-accordion-item-button--text-size-mode--default profile-accordion-item-button--content-alignment-mode--default" id="accordion__heading-raa-3" aria-disabled="false" aria-expanded="false" aria-controls="accordion__panel-raa-3" role="button" tabindex="0" data-accordion-component="AccordionItemButton"><span class="profile-accordion-item-button__label">Concepts</span><span class="animated-expand-icon"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="animated-expand-icon__icon"><path d="M12 1v22M23 12H1" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round"></path></svg></span></div></div><div data-accordion-component="AccordionItemPanel" class="accordion__panel" id="accordion__panel-raa-3" hidden=""><div class="profile-publication-card-keyword-accordion__container"><div class="profile-publication-card-keyword-list"><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Pediatric%20Autoimmune%20Neuropsychiatric%20Disorders%20Associated%20with%20Streptococcus" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Pediatric%20acute-onset%20neuropsychiatric%20syndrome" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Pediatric acute-onset neuropsychiatric syndrome</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Striatal%20cholinergic%20interneurons" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Striatal cholinergic interneurons</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Cholinergic%20interneurons" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Cholinergic interneurons</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Obsessive-compulsive%20symptoms" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Obsessive-compulsive symptoms</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Modulate%20basal%20ganglia%20function" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Modulate basal ganglia function</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Neuropsychiatric%20syndrome" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Neuropsychiatric syndrome</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Significant%20obsessive-compulsive%20symptoms" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Significant obsessive-compulsive symptoms</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Basal%20ganglia%20function" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Basal ganglia function</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Ex%20vivo%20brain%20slices" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Ex vivo brain slices</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Severe%20food%20restriction" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Severe food restriction</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Elevated%20antibodies" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Elevated antibodies</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Clinical%20history" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Clinical history</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Patient%20plasma" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Patient plasma</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Neuropsychiatric%20manifestations" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Neuropsychiatric manifestations</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Streptococcus%20infection" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Streptococcus infection</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Brain%20slices" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Brain slices</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Symptom%20flares" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Symptom flares</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Control%20plasma" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Control plasma</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Food%20restriction" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Food restriction</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Serum%20antibodies" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Serum antibodies</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Human%20brain" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Human brain</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Infection" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Infection</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Abrupt%20onset" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Abrupt onset</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Clinical%20context" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Clinical context</span></a></span></div></div></div></div></div></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white profile-publication-card" aria-label="Early Developmental Origins of Cortical Disorders Modeled in Human Neural Stem Cells."><div class="profile-publication-card__content-container"><div class="profile-publication-card__content"><h5 class="profile-publication-card__title"><a href="https://pubmed.ncbi.nlm.nih.gov/38915580" class="profile-publication-card__link">Early Developmental Origins of Cortical Disorders Modeled in Human Neural Stem Cells.</a></h5><cite class="profile-publication-card__citation">Mato-Blanco X, Kim SK, Jourdon A, Ma S, Tebbenkamp ATN, Liu F, Duque A, Vaccarino FM, Sestan N, Colantuoni C, Rakic P, Santpere G, Micali N. Early Developmental Origins of Cortical Disorders Modeled in Human Neural Stem Cells. BioRxiv 2024 <a href="https://pubmed.ncbi.nlm.nih.gov/38915580" target="_blank">PMID: 38915580</a>, DOI: 10.1101/2024.06.14.598925.</cite><div class="profile-publication-card__category">Peer-Reviewed Original Research</div></div></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white profile-publication-card" aria-label="Massively parallel characterization of regulatory elements in the developing human cortex"><div class="profile-publication-card__content-container"><div class="profile-publication-card__content"><h5 class="profile-publication-card__title"><a href="https://pubmed.ncbi.nlm.nih.gov/38781390" class="profile-publication-card__link">Massively parallel characterization of regulatory elements in the developing human cortex</a></h5><cite class="profile-publication-card__citation">Deng C, Whalen S, Steyert M, Ziffra R, Przytycki P, Inoue F, Pereira D, Capauto D, Norton S, Vaccarino F, Pollen A, Nowakowski T, Ahituv N, Pollard K, Akbarian S, Abyzov A, Ahituv N, Arasappan D, Almagro Armenteros J, Beliveau B, Bendl J, Berretta S, Bharadwaj R, Bhattacharya A, Bicks L, Brennand K, Capauto D, Champagne F, Chatterjee T, Chatzinakos C, Chen Y, Chen H, Cheng Y, Cheng L, Chess A, Chien J, Chu Z, Clarke D, Clement A, Collado-Torres L, Cooper G, Crawford G, Dai R, Daskalakis N, Davila-Velderrain J, Deep-Soboslay A, Deng C, DiPietro C, Dracheva S, Drusinsky S, Duan Z, Duong D, Dursun C, Eagles N, Edelstein J, Emani P, Fullard J, Galani K, Galeev T, Gandal M, Gaynor S, Gerstein M, Geschwind D, Girdhar K, Goes F, Greenleaf W, Grundman J, Guo H, Guo Q, Gupta C, Hadas Y, Hallmayer J, Han X, Haroutunian V, Hawken N, He C, Henry E, Hicks S, Ho M, Ho L, Hoffman G, Huang Y, Huuki-Myers L, Hwang A, Hyde T, Iatrou A, Inoue F, Jajoo A, Jensen M, Jiang L, Jin P, Jin T, Jops C, Jourdon A, Kawaguchi R, Kellis M, Khullar S, Kleinman J, Kleopoulos S, Kozlenkov A, Kriegstein A, Kundaje A, Kundu S, Lee C, Lee D, Li J, Li M, Lin X, Liu S, Liu J, Liu J, Liu C, Liu S, Lou S, Loupe J, Lu D, Ma S, Ma L, Margolis M, Mariani J, Martinowich K, Maynard K, Mazariegos S, Meng R, Myers R, Micallef C, Mikhailova T, Ming G, Mohammadi S, Monte E, Montgomery K, Moore J, Moran J, Mukamel E, Nairn A, Nemeroff C, Ni P, Norton S, Nowakowski T, Omberg L, Page S, Park S, Patowary A, Pattni R, Pertea G, Peters M, Phalke N, Pinto D, Pjanic M, Pochareddy S, Pollard K, Pollen A, Pratt H, Przytycki P, Purmann C, Qin Z, Qu P, Quintero D, Raj T, Rajagopalan A, Reach S, Reimonn T, Ressler K, Ross D, Roussos P, Rozowsky J, Ruth M, Ruzicka W, Sanders S, Schneider J, Scuderi S, Sebra R, Sestan N, Seyfried N, Shao Z, Shedd N, Shieh A, Shin J, Skarica M, Snijders C, Song H, State M, Stein J, Steyert M, Subburaju S, Sudhof T, Snyder M, Tao R, Therrien K, Tsai L, Urban A, Vaccarino F, van Bakel H, Vo D, Voloudakis G, Wamsley B, Wang T, Wang S, Wang D, Wang Y, Warrell J, Wei Y, Weimer A, Weinberger D, Wen C, Weng Z, Whalen S, White K, Willsey A, Won H, Wong W, Wu H, Wu F, Wuchty S, Wylie D, Xu S, Yap C, Zeng B, Zhang P, Zhang C, Zhang B, Zhang J, Zhang Y, Zhou X, Ziffra R, Zeier Z, Zintel T. Massively parallel characterization of regulatory elements in the developing human cortex. Science 2024, 384: eadh0559. <a href="https://pubmed.ncbi.nlm.nih.gov/38781390" target="_blank">PMID: 38781390</a>, <a href="https://doi.org/10.1126/science.adh0559" target="_blank">DOI: 10.1126/science.adh0559</a>.</cite><div class="profile-publication-card__category">Peer-Reviewed Original Research</div></div><div class="profile-publication-card__badge-container" aria-hidden="true"><div class="profile-publication-card__badge"><div class="profile-publication-card__badge-label">Citations</div></div><div class="profile-publication-card__badge"><div class="profile-publication-card__badge-label">Altmetric</div></div></div></div><div class="profile-publication-card__keyword-accordion"><div data-accordion-component="Accordion" class="accordion"><div data-accordion-component="AccordionItem" class="accordion__item"><div data-accordion-component="AccordionItemHeading" aria-level="6" role="heading" class="accordion__heading"><div class="profile-accordion-item-button profile-accordion-item-button--color-mode--navy profile-accordion-item-button--thickness-mode--bold profile-accordion-item-button--text-size-mode--default profile-accordion-item-button--content-alignment-mode--default" id="accordion__heading-raa-4" aria-disabled="false" aria-expanded="false" aria-controls="accordion__panel-raa-4" role="button" tabindex="0" data-accordion-component="AccordionItemButton"><span class="profile-accordion-item-button__label">MeSH Keywords and Concepts</span><span class="animated-expand-icon"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="animated-expand-icon__icon"><path d="M12 1v22M23 12H1" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round"></path></svg></span></div></div><div data-accordion-component="AccordionItemPanel" class="accordion__panel" id="accordion__panel-raa-4" hidden=""><div class="profile-publication-card-keyword-accordion__container"><div class="profile-publication-card-keyword-list"><span class="profile-publication-card-keyword-list__keyword-label">MeSH Keywords</span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=2423" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Cerebral Cortex</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=2717" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Chromatin</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=29166" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Deep Learning</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=4539" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Enhancer Elements, Genetic</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=17255" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Gene Expression Regulation, Developmental</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=6498" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Humans</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=24871" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Neurogenesis</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=9054" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Neurons</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=9503" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Organoids</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=11526" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Regulatory Sequences, Nucleic Acid</span></a></span></div></div><div class="profile-publication-card-keyword-accordion__container"><div class="profile-publication-card-keyword-list"><span class="profile-publication-card-keyword-list__keyword-label">Concepts</span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Gene%20regulatory%20elements" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Gene regulatory elements</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Regulatory%20elements" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Regulatory elements</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Regulation%20of%20enhancer%20activity" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Regulation of enhancer activity</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Characterization%20of%20regulatory%20elements" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Characterization of regulatory elements</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Cis-regulatory%20activity" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Cis-regulatory activity</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Neuronal%20development" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Neuronal development</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Primary%20cells" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Primary cells</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Enhanced%20activity" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Enhanced activity</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Gene%20regulation" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Gene regulation</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Human%20neuronal%20development" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Human neuronal development</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Nucleotide%20changes" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Nucleotide changes</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Enhancer%20sequences" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Enhancer sequences</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Sequence%20basis" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Sequence basis</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Upstream%20regulator" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Upstream regulator</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Comprehensive%20catalog" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Comprehensive catalog</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Human%20cells" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Human cells</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Developing%20cortex" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Developing cortex</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Sequence" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Sequence</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Variants" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Variants</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Organoids" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Organoids</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Cells" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Cells</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Cerebral%20organoids" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Cerebral organoids</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Cortex" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Cortex</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Human%20cortex" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Human cortex</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Nucleotide" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Nucleotide</span></a></span></div></div></div></div></div></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white profile-publication-card" aria-label="Evaluating performance and applications of sample-wise cell deconvolution methods on human brain transcriptomic data"><div class="profile-publication-card__content-container"><div class="profile-publication-card__content"><h5 class="profile-publication-card__title"><a href="https://pubmed.ncbi.nlm.nih.gov/38781336" class="profile-publication-card__link">Evaluating performance and applications of sample-wise cell deconvolution methods on human brain transcriptomic data</a></h5><cite class="profile-publication-card__citation">Dai R, Chu T, Zhang M, Wang X, Jourdon A, Wu F, Mariani J, Vaccarino F, Lee D, Fullard J, Hoffman G, Roussos P, Wang Y, Wang X, Pinto D, Wang S, Zhang C, consortium P, Chen C, Liu C. Evaluating performance and applications of sample-wise cell deconvolution methods on human brain transcriptomic data. Science Advances 2024, 10: eadh2588. <a href="https://pubmed.ncbi.nlm.nih.gov/38781336" target="_blank">PMID: 38781336</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11114236" target="_blank">PMCID: PMC11114236</a>, <a href="https://doi.org/10.1126/sciadv.adh2588" target="_blank">DOI: 10.1126/sciadv.adh2588</a>.</cite><div class="profile-publication-card__category">Peer-Reviewed Original Research</div></div><div class="profile-publication-card__badge-container" aria-hidden="true"><div class="profile-publication-card__badge"><div class="profile-publication-card__badge-label">Citations</div></div><div class="profile-publication-card__badge"><div class="profile-publication-card__badge-label">Altmetric</div></div></div></div><div class="profile-publication-card__keyword-accordion"><div data-accordion-component="Accordion" class="accordion"><div data-accordion-component="AccordionItem" class="accordion__item"><div data-accordion-component="AccordionItemHeading" aria-level="6" role="heading" class="accordion__heading"><div class="profile-accordion-item-button profile-accordion-item-button--color-mode--navy profile-accordion-item-button--thickness-mode--bold profile-accordion-item-button--text-size-mode--default profile-accordion-item-button--content-alignment-mode--default" id="accordion__heading-raa-5" aria-disabled="false" aria-expanded="false" aria-controls="accordion__panel-raa-5" role="button" tabindex="0" data-accordion-component="AccordionItemButton"><span class="profile-accordion-item-button__label">MeSH Keywords and Concepts</span><span class="animated-expand-icon"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="animated-expand-icon__icon"><path d="M12 1v22M23 12H1" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round"></path></svg></span></div></div><div data-accordion-component="AccordionItemPanel" class="accordion__panel" id="accordion__panel-raa-5" hidden=""><div class="profile-publication-card-keyword-accordion__container"><div class="profile-publication-card-keyword-list"><span class="profile-publication-card-keyword-list__keyword-label">MeSH Keywords</span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=311" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Adult</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=517" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Alzheimer Disease</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=1831" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Brain</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=19263" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Gene Expression Profiling</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=24710" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Genome-Wide Association Study</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=6498" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Humans</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=12015" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Schizophrenia</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=16339" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Sequence Analysis, RNA</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=26056" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Single-Cell Analysis</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=26173" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Transcriptome</span></a></span></div></div><div class="profile-publication-card-keyword-accordion__container"><div class="profile-publication-card-keyword-list"><span class="profile-publication-card-keyword-list__keyword-label">Concepts</span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Human%20brain%20transcriptome%20data" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Human brain transcriptome data</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Brain%20transcriptomic%20data" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Brain transcriptomic data</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=RNA-seq" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">RNA-seq</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Transcriptome%20data" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Transcriptome data</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Cell-type%20gene%20expression" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Cell-type gene expression</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Gene%20expression" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Gene expression</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Cell-type%20proportions" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Cell-type proportions</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Single-cell%20data" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Single-cell data</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Multiple%20brain%20disorders" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Multiple brain disorders</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Brain%20cell%20types" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Brain cell types</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Cell%20deconvolution%20methods" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Cell deconvolution methods</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Postmortem%20brains" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Postmortem brains</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=RNA%20sequencing" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">RNA sequencing</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Brain%20disorders" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Brain disorders</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Brain%20development" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Brain development</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Schizophrenia" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Schizophrenia</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=EQTL" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">EQTL</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Alzheimer%27s%20disease" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Alzheimer's disease</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Cell%20types" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Cell types</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Organoid%20samples" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Organoid samples</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Brain" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Brain</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Biological%20applications" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Biological applications</span></a></span></div></div></div></div></div></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white profile-publication-card" aria-label="Specification of human regional brain lineages using orthogonal gradients of WNT and SHH in organoids."><div class="profile-publication-card__content-container"><div class="profile-publication-card__content"><h5 class="profile-publication-card__title"><a href="https://pubmed.ncbi.nlm.nih.gov/38798404" class="profile-publication-card__link">Specification of human regional brain lineages using orthogonal gradients of WNT and SHH in organoids.</a></h5><cite class="profile-publication-card__citation">Scuderi S, Kang TY, Jourdon A, Yang L, Wu F, Nelson A, Anderson GM, Mariani J, Sarangi V, Abyzov A, Levchenko A, Vaccarino FM. Specification of human regional brain lineages using orthogonal gradients of WNT and SHH in organoids. BioRxiv 2024 <a href="https://pubmed.ncbi.nlm.nih.gov/38798404" target="_blank">PMID: 38798404</a>, DOI: 10.1101/2024.05.18.594828.</cite><div class="profile-publication-card__category">Peer-Reviewed Original Research</div></div></div></article></li></ul></section><div class="profile-details-see-all-button profile-details-see-all-button--width-mode--normal"><div class="profile-details-see-all-button__wrapper"><a href="/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino" tabindex="0" class="button button--large button--primary button--color-mode--blue button--link button-with-icon"><span class="button__label">See All Publications</span><span class="button__icon" aria-hidden="true"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="profile-details-see-all-button__icon"><path fill="currentcolor" fill-rule="evenodd" d="M14.004.525a.503.503 0 0 0 .017.926c.08.033.513.037 3.936.037h3.847l-8.416 8.418c-4.628 4.63-8.434 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class="achievement-card__title">International Society of Developmental Neuroscience</h3><div data-accordion-component="Accordion" class="accordion"><div data-accordion-component="AccordionItem" class="accordion__item"><div class="achievement-card__metadata-list"><span class="achievement-card__metadata-container"><span class="achievement-card__metadata">Professional Organizations</span><span class="achievement-card__separator"></span></span><span class="achievement-card__metadata-container"><span class="achievement-card__metadata achievement-card__metadata--highlighted">Board Member</span></span></div><div data-accordion-component="AccordionItemHeading" class="achievement-card__details-button-container" aria-level="4" role="heading"><div class="profile-accordion-item-button profile-accordion-item-button--color-mode--navy profile-accordion-item-button--thickness-mode--bold profile-accordion-item-button--text-size-mode--default 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class="achievement-service-card__icon"><rect width="22.5" height="19.5" x="0.75" y="3.75" rx="1.5" ry="1.5" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></rect><path d="M.75 9.75h22.5M6.75 6V.75M17.25 6V.75M5.625 13.5a.375.375 0 1 0 .375.375.375.375 0 0 0-.375-.375M5.625 18.75a.375.375 0 1 0 .375.375.375.375 0 0 0-.375-.375M12 13.5a.375.375 0 1 0 .375.375A.375.375 0 0 0 12 13.5M12 18.75a.375.375 0 1 0 .375.375.375.375 0 0 0-.375-.375M18.375 13.5a.375.375 0 1 0 .375.375.375.375 0 0 0-.375-.375M18.375 18.75a.375.375 0 1 0 .375.375.375.375 0 0 0-.375-.375" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg>05/01/2008 - Present</span></div></div></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white achievement-card achievement-card--type--activity" aria-label="Frontiers in Neurogenesis"><span class="achievement-card__label">activity</span><h3 class="achievement-card__title">Frontiers in Neurogenesis</h3><div data-accordion-component="Accordion" class="accordion"><div data-accordion-component="AccordionItem" class="accordion__item"><div class="achievement-card__metadata-list"><span class="achievement-card__metadata-container"><span class="achievement-card__metadata">Professional Organizations</span><span class="achievement-card__separator"></span></span><span class="achievement-card__metadata-container"><span class="achievement-card__metadata achievement-card__metadata--highlighted">Board Member</span></span></div><div data-accordion-component="AccordionItemHeading" class="achievement-card__details-button-container" aria-level="4" role="heading"><div class="profile-accordion-item-button profile-accordion-item-button--color-mode--navy profile-accordion-item-button--thickness-mode--bold profile-accordion-item-button--text-size-mode--default 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style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></rect><path d="M.75 9.75h22.5M6.75 6V.75M17.25 6V.75M5.625 13.5a.375.375 0 1 0 .375.375.375.375 0 0 0-.375-.375M5.625 18.75a.375.375 0 1 0 .375.375.375.375 0 0 0-.375-.375M12 13.5a.375.375 0 1 0 .375.375A.375.375 0 0 0 12 13.5M12 18.75a.375.375 0 1 0 .375.375.375.375 0 0 0-.375-.375M18.375 13.5a.375.375 0 1 0 .375.375.375.375 0 0 0-.375-.375M18.375 18.75a.375.375 0 1 0 .375.375.375.375 0 0 0-.375-.375" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg>1983 - Present</span></div></div></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white achievement-card achievement-card--type--activity" aria-label="Brain Research"><span class="achievement-card__label">activity</span><h3 class="achievement-card__title">Brain Research</h3><div 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profile-details-column-list--columns-on-desktop--1 profile-details-column-list--columns-on-tablet--1 profile-details-column-list--columns-on-mobile--1 profile-details-column-list--divided"><li class="profile-details-column-list-item"><article class="profile-details-media-list-item profile-details-media-list-item--right" aria-label="Reconstruction of lineage tree showing very early cell divisions of a living individual"><div class="profile-details-media-list-item__thumbnail-container"><div tabindex="0" role="button" aria-label="View the Reconstruction of lineage tree showing very early cell divisions of a living individual image" class="profile-details-media-thumbnail profile-details-media-thumbnail--clickable profile-details-media-thumbnail--rounded"><span class="" style="display:inline-block"></span></div></div><div class="profile-details-media-list-item__information-container"><h4><button type="button" class="profile-details-media-list-item__title-button" tabindex="-1"><span>Reconstruction of lineage tree showing very early cell divisions of a living individual</span></button></h4><div class="profile-details-media-list-item__description">The tree is based on mosaic single nucleotide variants (black) and indels (green) discovered in 25 fibroblast-derived iPSC lines from 4 skin biopsies and also present in blood, saliva and urine. Note that the first division is drastically asymmetric, with one daughter generating 90-70% of tissues and the other only 10-30%. For details see Fasching et al, Science 2021.</div></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-media-list-item profile-details-media-list-item--left" aria-label="Human iPSC- derived telencephalic organoid"><div class="profile-details-media-list-item__thumbnail-container"><div tabindex="0" role="button" aria-label="View the Human iPSC- derived telencephalic organoid image" class="profile-details-media-thumbnail profile-details-media-thumbnail--clickable profile-details-media-thumbnail--rounded"><span class="" style="display:inline-block"></span></div></div><div class="profile-details-media-list-item__information-container"><h4><button type="button" class="profile-details-media-list-item__title-button" tabindex="-1"><span>Human iPSC- derived telencephalic organoid</span></button></h4><div class="profile-details-media-list-item__description">Telencephalic organoid derived from human iPSC and grown in 3D culture. Red, progenitor cells stained for SOX1; green, immature neurons stinaed for bIII tubulin.</div></div></article></li></ul></div></section><section class="profile-details-content-section" aria-label="linksAndMedia News" id="links-news" tabindex="-1"><h3 class="profile-details-content-section__heading">News</h3><div class="profile-details-content-section__content"><div class="profile-details-news-list"><div class="profile-details-news-list__list"><div class="article-list"><ul class="article-list__post-container"><li class="article-list__post article-list__post--large article-list__post--with-bottom-indent"><article aria-label="Catalyzing Impact through Focused Research Funding: Flora Vaccarino" class="article-post article-post--large"><div class="article-post__date-container"><span class="article-post-date">September 11, 2024</span></div><a href="/childstudy/news-article/catalyzing-impact-through-focused-research-funding-flora-vaccarino/" class="article-post-content-link" aria-label="Catalyzing Impact through Focused Research Funding: Flora Vaccarino" tabindex="-1"><div class="article-post__thumbnail"><div class="article-post-thumbnail" style="aspect-ratio:16 / 9"><span class="" style="display:inline-block"></span></div></div><div class="article-post__title-wrapper"><h4 class="article-post-title article-post-title--size-mode--large">Catalyzing Impact through Focused Research Funding: Flora Vaccarino</h4></div></a><div class="article-post__link-details-wrapper"><div class="article-post-link-details"><a href="/childstudy/news-article/catalyzing-impact-through-focused-research-funding-flora-vaccarino/" tabindex="0" class="link link--size--small link--width--inline link--align--right link--color--black link--font--normal link--decorate-color--light-blue" aria-label="Read more about Catalyzing Impact through Focused Research Funding: Flora Vaccarino"><span class="link__label">Read more<span class="visually-hidden-content" role="presentation">about Catalyzing Impact through Focused Research Funding: Flora Vaccarino</span></span></a></div></div></article></li><li class="article-list__post article-list__post--large article-list__post--with-bottom-indent"><article aria-label="The power of collaboration" class="article-post article-post--large"><div class="article-post__date-container"><span class="article-post-date">March 20, 2024</span></div><a href="https://medicine.yale.edu/news/yale-medicine-magazine/article/the-power-of-collaboration" class="article-post-content-link" aria-label="The power of collaboration" tabindex="-1"><div class="article-post__thumbnail"><div class="article-post-thumbnail" style="aspect-ratio:16 / 9"><span class="" style="display:inline-block"></span></div></div><div class="article-post__title-wrapper"><h4 class="article-post-title article-post-title--size-mode--large">The power of collaboration</h4></div></a><div class="article-post__link-details-wrapper"><div class="article-post-link-details"><a href="https://medicine.yale.edu/news/yale-medicine-magazine/article/the-power-of-collaboration" tabindex="0" class="link link--size--small link--width--inline link--align--right link--color--black link--font--normal link--decorate-color--light-blue" aria-label="Read more about The power of collaboration"><span class="link__label">Read more<span class="visually-hidden-content" role="presentation">about The power of collaboration</span></span></a></div></div></article></li><li class="article-list__post article-list__post--large article-list__post--with-bottom-indent"><article aria-label="Researchers Investigate Head Size and Autism" class="article-post article-post--large"><div class="article-post__date-container"><span class="article-post-date">January 05, 2024</span></div><a href="https://site.autismadvocateparentingmagazine.com/wp-content/uploads/2024/01/Researchers_Investigate_Head_Size_and_Autism-789842.pdf" class="article-post-content-link" aria-label="Researchers Investigate Head Size and Autism, Source: AUTISM ADVOCATE Parenting Magazine" tabindex="-1"><div class="article-post__thumbnail"><div class="article-post-thumbnail" style="aspect-ratio:16 / 9"><span class="" style="display:inline-block"></span></div></div><div class="article-post__title-wrapper"><h4 class="article-post-title article-post-title--size-mode--large">Researchers Investigate Head Size and Autism</h4></div><span class="article-source-label article-post__source-label">Source: AUTISM ADVOCATE Parenting Magazine</span></a><div class="article-post__link-details-wrapper"><div class="article-post-link-details"><a href="https://site.autismadvocateparentingmagazine.com/wp-content/uploads/2024/01/Researchers_Investigate_Head_Size_and_Autism-789842.pdf" tabindex="0" class="link link--size--small link--width--inline link--align--right link--color--black link--font--normal link--decorate-color--light-blue" aria-label="Read more about Researchers Investigate Head Size and Autism"><span class="link__label">Read more<span class="visually-hidden-content" role="presentation">about Researchers Investigate Head Size and Autism</span></span></a></div></div></article></li><li class="article-list__post article-list__post--large article-list__post--with-bottom-indent"><article aria-label="Yale researchers find 2 types of autism, underscoring the need for different treatments" class="article-post article-post--large"><div class="article-post__date-container"><span class="article-post-date">September 07, 2023</span></div><a href="https://www.ctpublic.org/news/2023-09-07/yale-researchers-find-two-types-of-autism-underscoring-the-need-for-different-treatments" class="article-post-content-link" aria-label="Yale researchers find 2 types of autism, underscoring the need for different treatments, Source: Connecticut Public Radio" tabindex="-1"><div class="article-post__thumbnail"><div class="article-post-thumbnail" style="aspect-ratio:16 / 9"><span class="" style="display:inline-block"></span></div></div><div class="article-post__title-wrapper"><h4 class="article-post-title article-post-title--size-mode--large">Yale researchers find 2 types of autism, underscoring the need for different treatments</h4></div><span class="article-source-label article-post__source-label">Source: Connecticut Public Radio</span></a><div class="article-post__link-details-wrapper"><div class="article-post-link-details"><a href="https://www.ctpublic.org/news/2023-09-07/yale-researchers-find-two-types-of-autism-underscoring-the-need-for-different-treatments" tabindex="0" class="link link--size--small link--width--inline link--align--right link--color--black link--font--normal link--decorate-color--light-blue" aria-label="Read more about Yale researchers find 2 types of autism, underscoring the need for different treatments"><span class="link__label">Read more<span class="visually-hidden-content" role="presentation">about Yale researchers find 2 types of autism, 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class="profile-detailed-info-list-item__name">Monica Mleczek</span><div class="LinesEllipsis text-overflow profile-detailed-info-list-item__title">Administrative Assistant Child Study Center; Administrative Assistant in the Child Study Center<wbr/></div></div></a></div></div></li></ul></div></div></div></section><section class="profile-details-content-section" aria-label="getInTouch Events" id="get-in-touch-events" tabindex="-1"><h3 class="profile-details-content-section__heading">Events</h3><div class="profile-details-content-section__content"><div class="event-list"><div class="event-list__groups-container"><section class="event-list__group" aria-label="Events on May 25, 2025 "><div class="event-list__date"><div class="event-date event-date--medium"><span class="event-date__month-year">May 2025</span><span class="event-date__day event-date__day--multiple-days">25-28</span><span class="event-date__day-of-week">Multiple Days</span></div></div><ul 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Chapter 53 Tourette syndrome. 2025, 951-962. <a href=\\\"https://doi.org/10.1016/b978-0-443-19176-3.00044-3\\\" target=\\\"_blank\\\">DOI: 10.1016/b978-0-443-19176-3.00044-3</a>.\",\"@context\":\"http://schema.org\"}"},{"schemaName":"MedicalScholarlyArticle","jsonData":"{\"@type\":\"MedicalScholarlyArticle\",\"publicationType\":\"Journal Article\",\"inLanguage\":\"en-US\",\"headline\":\"A framework for neural organoids, assembloids and transplantation studies\",\"url\":\"https://pubmed.ncbi.nlm.nih.gov/39653126\",\"author\":[{\"@type\":\"Person\",\"name\":\"Flora Vaccarino\",\"description\":\"Flora Vaccarino is the Harris Professor at the Child Study Center and Professor in the Department of Neuroscience at Yale University. She received her MD from the University of Padova in Italy. 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They then performed an extensive comparison of the organoid’s transcriptome and noncoding elements with isogenic postmortem human fetal cortex and characterized gene regulatory mechanisms that shape the earliest cell fate decisions in human cortical development. Her lab has generated an extensive collection of patient-derived iPSC lines to study altered gene regulatory mechanisms in Autism Spectrum Disorders. Her interests include human somatic genomic variation as a tool to study lineage specification in human embryonic development. She was one of the fiunding members of the Brain Somatic Mosaicism Network (BSMN), a multi-site consortium that studied somatic mosaicism and its implication for neuropsychiatric diseases. Vaccarino is a Fellow of American Association for the Advancement of Science and a member of the PsychENCODE the Somatic Mosaicism across Human Tissues ( SMaHT) Consortia.\",\"url\":\"https://medicine.yale.edu/profile/flora-vaccarino/\",\"email\":\"flora.vaccarino@yale.edu\",\"telephone\":\"+12037374147\",\"image\":{\"@type\":\"ImageObject\",\"url\":\"https://ysm-res.cloudinary.com/image/upload/c_limit,f_auto,h_630,q_auto,w_1200/v1/yms/prod/35647f85-7587-4df1-8e91-c3a764ccd6cb\",\"description\":\"2024-09-30-Flora-Vaccarino-\",\"height\":1200,\"width\":630,\"@context\":\"http://schema.org\"},\"address\":[],\"workLocation\":[],\"honorificSuffix\":[\"MD\"],\"award\":[],\"jobTitle\":[\"Harris Professor in the Child Study Center\"],\"affiliation\":[{\"@type\":\"Organization\",\"name\":\"Center for Brain & Mind Health\",\"url\":\"https://medicine.yale.edu/brain-mind-health/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Child & Adolescent Psychiatry Training Program\",\"url\":\"https://medicine.yale.edu/childstudy/education-and-training/clinical-internships-residencies-and-fellowships/child-and-adolescent-psychiatry-fellowship/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Child Study Center\",\"url\":\"https://medicine.yale.edu/childstudy/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Embryonic Stem Cell Research Oversight\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Interdepartmental Neuroscience Program\",\"url\":\"https://medicine.yale.edu/inp/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Kavli Institute for Neuroscience\",\"url\":\"https://medicine.yale.edu/kavli/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Neuroscience\",\"url\":\"https://medicine.yale.edu/neuroscience/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Neuroscience Track\",\"url\":\"https://medicine.yale.edu/bbs/tracks/neuroscience/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Program in Neurodevelopment and Regeneration\",\"url\":\"https://medicine.yale.edu/neurodevelopment/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Tic Disorder & Obsessive Compulsive Disorder Program\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Vaccarino Lab\",\"url\":\"https://medicine.yale.edu/lab/vaccarino/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"WHRY Pilot Project Program Investigators\",\"url\":\"https://medicine.yale.edu/whr/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Women's Health Research at Yale\",\"url\":\"https://medicine.yale.edu/whr/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Wu Tsai Institute\",\"url\":\"https://wti.yale.edu/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Center for Genomic Health\",\"url\":\"https://medicine.yale.edu/ycgh/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Combined Program in the Biological and Biomedical Sciences (BBS)\",\"url\":\"https://medicine.yale.edu/bbs/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Stem Cell Center\",\"url\":\"https://medicine.yale.edu/stemcell/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Ventures\",\"url\":\"https://ventures.yale.edu/\",\"@context\":\"http://schema.org\"}],\"alumniOf\":[{\"@type\":\"Organization\",\"name\":\"Yale University, School of Medicine, Psychiatry (1991)\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"FIDIA-Georgetown Institute for the Neurosciences (1987)\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"NIMH-Laboratory of Preclinical Pharmacology (1985)\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Padua University Medical University (1979)\",\"@context\":\"http://schema.org\"}],\"sameAs\":[],\"@context\":\"http://schema.org\"}],\"description\":\"Pașca S, Arlotta P, Bateup H, Camp J, Cappello S, Gage F, Knoblich J, Kriegstein A, Lancaster M, Ming G, Novarino G, Okano H, Parmar M, Park I, Reiner O, Song H, Studer L, Takahashi J, Temple S, Testa G, Treutlein B, Vaccarino F, Vanderhaeghen P, Young-Pearse T. A framework for neural organoids, assembloids and transplantation studies. Nature 2024, 1-3. <a href=\\\"https://pubmed.ncbi.nlm.nih.gov/39653126\\\" target=\\\"_blank\\\">PMID: 39653126</a>, <a href=\\\"https://doi.org/10.1038/s41586-024-08487-6\\\" target=\\\"_blank\\\">DOI: 10.1038/s41586-024-08487-6</a>.\",\"@context\":\"http://schema.org\"}"},{"schemaName":"MedicalScholarlyArticle","jsonData":"{\"@type\":\"MedicalScholarlyArticle\",\"publicationType\":\"Journal Article\",\"inLanguage\":\"en-US\",\"headline\":\"Transgenerational transmission of post-zygotic mutations suggests symmetric contribution of first two blastome\",\"url\":\"https://pubmed.ncbi.nlm.nih.gov/39438473\",\"author\":[{\"@type\":\"Person\",\"name\":\"Flora Vaccarino\",\"description\":\"Flora Vaccarino is the Harris Professor at the Child Study Center and Professor in the Department of Neuroscience at Yale University. She received her MD from the University of Padova in Italy. 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They then performed an extensive comparison of the organoid’s transcriptome and noncoding elements with isogenic postmortem human fetal cortex and characterized gene regulatory mechanisms that shape the earliest cell fate decisions in human cortical development. Her lab has generated an extensive collection of patient-derived iPSC lines to study altered gene regulatory mechanisms in Autism Spectrum Disorders. Her interests include human somatic genomic variation as a tool to study lineage specification in human embryonic development. She was one of the fiunding members of the Brain Somatic Mosaicism Network (BSMN), a multi-site consortium that studied somatic mosaicism and its implication for neuropsychiatric diseases. 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Transgenerational transmission of post-zygotic mutations suggests symmetric contribution of first two blastomeres to human germline. Nature Communications 2024, 15: 9117. <a href=\\\"https://pubmed.ncbi.nlm.nih.gov/39438473\\\" target=\\\"_blank\\\">PMID: 39438473</a>, <a href=\\\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11496613\\\" target=\\\"_blank\\\">PMCID: PMC11496613</a>, <a href=\\\"https://doi.org/10.1038/s41467-024-53485-x\\\" target=\\\"_blank\\\">DOI: 10.1038/s41467-024-53485-x</a>.\",\"@context\":\"http://schema.org\"}"},{"schemaName":"MedicalScholarlyArticle","jsonData":"{\"@type\":\"MedicalScholarlyArticle\",\"publicationType\":\"Journal Article\",\"inLanguage\":\"en-US\",\"headline\":\"Tourette syndrome\",\"author\":[{\"@type\":\"Person\",\"name\":\"Flora Vaccarino\",\"description\":\"Flora Vaccarino is the Harris Professor at the Child Study Center and Professor in the Department of Neuroscience at Yale University. 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They then performed an extensive comparison of the organoid’s transcriptome and noncoding elements with isogenic postmortem human fetal cortex and characterized gene regulatory mechanisms that shape the earliest cell fate decisions in human cortical development. Her lab has generated an extensive collection of patient-derived iPSC lines to study altered gene regulatory mechanisms in Autism Spectrum Disorders. Her interests include human somatic genomic variation as a tool to study lineage specification in human embryonic development. She was one of the fiunding members of the Brain Somatic Mosaicism Network (BSMN), a multi-site consortium that studied somatic mosaicism and its implication for neuropsychiatric diseases. Vaccarino is a Fellow of American Association for the Advancement of Science and a member of the PsychENCODE the Somatic Mosaicism across Human Tissues ( SMaHT) Consortia.\",\"url\":\"https://medicine.yale.edu/profile/flora-vaccarino/\",\"email\":\"flora.vaccarino@yale.edu\",\"telephone\":\"+12037374147\",\"image\":{\"@type\":\"ImageObject\",\"url\":\"https://ysm-res.cloudinary.com/image/upload/c_limit,f_auto,h_630,q_auto,w_1200/v1/yms/prod/35647f85-7587-4df1-8e91-c3a764ccd6cb\",\"description\":\"2024-09-30-Flora-Vaccarino-\",\"height\":1200,\"width\":630,\"@context\":\"http://schema.org\"},\"address\":[],\"workLocation\":[],\"honorificSuffix\":[\"MD\"],\"award\":[],\"jobTitle\":[\"Harris Professor in the Child Study Center\"],\"affiliation\":[{\"@type\":\"Organization\",\"name\":\"Center for Brain & Mind Health\",\"url\":\"https://medicine.yale.edu/brain-mind-health/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Child & Adolescent Psychiatry Training Program\",\"url\":\"https://medicine.yale.edu/childstudy/education-and-training/clinical-internships-residencies-and-fellowships/child-and-adolescent-psychiatry-fellowship/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Child Study Center\",\"url\":\"https://medicine.yale.edu/childstudy/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Embryonic Stem Cell Research Oversight\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Interdepartmental Neuroscience Program\",\"url\":\"https://medicine.yale.edu/inp/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Kavli Institute for Neuroscience\",\"url\":\"https://medicine.yale.edu/kavli/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Neuroscience\",\"url\":\"https://medicine.yale.edu/neuroscience/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Neuroscience Track\",\"url\":\"https://medicine.yale.edu/bbs/tracks/neuroscience/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Program in Neurodevelopment and Regeneration\",\"url\":\"https://medicine.yale.edu/neurodevelopment/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Tic Disorder & Obsessive Compulsive Disorder Program\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Vaccarino Lab\",\"url\":\"https://medicine.yale.edu/lab/vaccarino/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"WHRY Pilot Project Program Investigators\",\"url\":\"https://medicine.yale.edu/whr/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Women's Health Research at Yale\",\"url\":\"https://medicine.yale.edu/whr/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Wu Tsai Institute\",\"url\":\"https://wti.yale.edu/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Center for Genomic Health\",\"url\":\"https://medicine.yale.edu/ycgh/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Combined Program in the Biological and Biomedical Sciences (BBS)\",\"url\":\"https://medicine.yale.edu/bbs/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Stem Cell Center\",\"url\":\"https://medicine.yale.edu/stemcell/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Ventures\",\"url\":\"https://ventures.yale.edu/\",\"@context\":\"http://schema.org\"}],\"alumniOf\":[{\"@type\":\"Organization\",\"name\":\"Yale University, School of Medicine, Psychiatry (1991)\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"FIDIA-Georgetown Institute for the Neurosciences (1987)\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"NIMH-Laboratory of Preclinical Pharmacology (1985)\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Padua University Medical University (1979)\",\"@context\":\"http://schema.org\"}],\"sameAs\":[],\"@context\":\"http://schema.org\"}],\"description\":\"Abdallah SB, Fasching L, Brady M, Bloch MH, Lombroso P, Vaccarino FM, Fernandez TV. Tourette syndrome. In: Rosenberg RN, Pascual JM, editors. Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease, Seventh Edition San Diego, CA: Elsevier/Academic Press; 2024. Chapter 53; p.951-962. \",\"@context\":\"http://schema.org\"}"},{"schemaName":"MedicalScholarlyArticle","jsonData":"{\"@type\":\"MedicalScholarlyArticle\",\"publicationType\":\"Journal Article\",\"inLanguage\":\"en-US\",\"headline\":\"Elevated antibody binding to striatal cholinergic interneurons in patients with pediatric acute-onset neuropsy\",\"url\":\"https://pubmed.ncbi.nlm.nih.gov/39084540\",\"author\":[{\"@type\":\"Person\",\"name\":\"Flora Vaccarino\",\"description\":\"Flora Vaccarino is the Harris Professor at the Child Study Center and Professor in the Department of Neuroscience at Yale University. She received her MD from the University of Padova in Italy. 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They then performed an extensive comparison of the organoid’s transcriptome and noncoding elements with isogenic postmortem human fetal cortex and characterized gene regulatory mechanisms that shape the earliest cell fate decisions in human cortical development. Her lab has generated an extensive collection of patient-derived iPSC lines to study altered gene regulatory mechanisms in Autism Spectrum Disorders. Her interests include human somatic genomic variation as a tool to study lineage specification in human embryonic development. She was one of the fiunding members of the Brain Somatic Mosaicism Network (BSMN), a multi-site consortium that studied somatic mosaicism and its implication for neuropsychiatric diseases. Vaccarino is a Fellow of American Association for the Advancement of Science and a member of the PsychENCODE the Somatic Mosaicism across Human Tissues ( SMaHT) Consortia.\",\"url\":\"https://medicine.yale.edu/profile/flora-vaccarino/\",\"email\":\"flora.vaccarino@yale.edu\",\"telephone\":\"+12037374147\",\"image\":{\"@type\":\"ImageObject\",\"url\":\"https://ysm-res.cloudinary.com/image/upload/c_limit,f_auto,h_630,q_auto,w_1200/v1/yms/prod/35647f85-7587-4df1-8e91-c3a764ccd6cb\",\"description\":\"2024-09-30-Flora-Vaccarino-\",\"height\":1200,\"width\":630,\"@context\":\"http://schema.org\"},\"address\":[],\"workLocation\":[],\"honorificSuffix\":[\"MD\"],\"award\":[],\"jobTitle\":[\"Harris Professor in the Child Study Center\"],\"affiliation\":[{\"@type\":\"Organization\",\"name\":\"Center for Brain & Mind Health\",\"url\":\"https://medicine.yale.edu/brain-mind-health/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Child & Adolescent Psychiatry Training Program\",\"url\":\"https://medicine.yale.edu/childstudy/education-and-training/clinical-internships-residencies-and-fellowships/child-and-adolescent-psychiatry-fellowship/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Child Study Center\",\"url\":\"https://medicine.yale.edu/childstudy/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Embryonic Stem Cell Research Oversight\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Interdepartmental Neuroscience Program\",\"url\":\"https://medicine.yale.edu/inp/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Kavli Institute for Neuroscience\",\"url\":\"https://medicine.yale.edu/kavli/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Neuroscience\",\"url\":\"https://medicine.yale.edu/neuroscience/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Neuroscience Track\",\"url\":\"https://medicine.yale.edu/bbs/tracks/neuroscience/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Program in Neurodevelopment and Regeneration\",\"url\":\"https://medicine.yale.edu/neurodevelopment/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Tic Disorder & Obsessive Compulsive Disorder Program\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Vaccarino Lab\",\"url\":\"https://medicine.yale.edu/lab/vaccarino/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"WHRY Pilot Project Program Investigators\",\"url\":\"https://medicine.yale.edu/whr/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Women's Health Research at Yale\",\"url\":\"https://medicine.yale.edu/whr/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Wu Tsai Institute\",\"url\":\"https://wti.yale.edu/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Center for Genomic Health\",\"url\":\"https://medicine.yale.edu/ycgh/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Combined Program in the Biological and Biomedical Sciences (BBS)\",\"url\":\"https://medicine.yale.edu/bbs/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Stem Cell Center\",\"url\":\"https://medicine.yale.edu/stemcell/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Ventures\",\"url\":\"https://ventures.yale.edu/\",\"@context\":\"http://schema.org\"}],\"alumniOf\":[{\"@type\":\"Organization\",\"name\":\"Yale University, School of Medicine, Psychiatry (1991)\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"FIDIA-Georgetown Institute for the Neurosciences (1987)\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"NIMH-Laboratory of Preclinical Pharmacology (1985)\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Padua University Medical University (1979)\",\"@context\":\"http://schema.org\"}],\"sameAs\":[],\"@context\":\"http://schema.org\"}],\"description\":\"Xu J, Frankovich J, Liu R, Thienemann M, Silverman M, Farhadian B, Willett T, Manko C, Columbo L, Leibold C, Vaccarino F, Che A, Pittenger C. Elevated antibody binding to striatal cholinergic interneurons in patients with pediatric acute-onset neuropsychiatric syndrome. Brain Behavior And Immunity 2024, 122: 241-255. <a href=\\\"https://pubmed.ncbi.nlm.nih.gov/39084540\\\" target=\\\"_blank\\\">PMID: 39084540</a>, <a href=\\\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11569416\\\" target=\\\"_blank\\\">PMCID: PMC11569416</a>, <a href=\\\"https://doi.org/10.1016/j.bbi.2024.07.044\\\" target=\\\"_blank\\\">DOI: 10.1016/j.bbi.2024.07.044</a>.\",\"@context\":\"http://schema.org\"}"},{"schemaName":"MedicalScholarlyArticle","jsonData":"{\"@type\":\"MedicalScholarlyArticle\",\"publicationType\":\"Journal Article\",\"inLanguage\":\"en-US\",\"headline\":\"Early Developmental Origins of Cortical Disorders Modeled in Human Neural Stem Cells.\",\"url\":\"https://pubmed.ncbi.nlm.nih.gov/38915580\",\"author\":[{\"@type\":\"Person\",\"name\":\"Flora Vaccarino\",\"description\":\"Flora Vaccarino is the Harris Professor at the Child Study Center and Professor in the Department of Neuroscience at Yale University. She received her MD from the University of Padova in Italy. She spent few years as Neuropharmacology Fellow at NIH, trained in clinical psychiatry at Yale, and then was a Research Fellow in developmental genetics at the Yale School of Medicine, where she raised through the ranks to Assistant, Associate and full Professor. Vaccarino leads a multidisciplinary research group working towards new directions for the study of mammalian brain development, particularly human, using stem cell biology and genomics as tools. She has been studying brain development in animal models for over 20 years, focusing on the role of growth factor receptor signaling in the regulation of stem cell behavior and cerebral cortex morphogenesis. Inspired by Sasai’s work, Vaccarino and her lab pioneered the generation of 3D brain organoids from induced pluripotent stem cells (iPSCs) in 2012, and showed that they recapitulate early fetal development of the human cerebral cortex. They then performed an extensive comparison of the organoid’s transcriptome and noncoding elements with isogenic postmortem human fetal cortex and characterized gene regulatory mechanisms that shape the earliest cell fate decisions in human cortical development. Her lab has generated an extensive collection of patient-derived iPSC lines to study altered gene regulatory mechanisms in Autism Spectrum Disorders. Her interests include human somatic genomic variation as a tool to study lineage specification in human embryonic development. She was one of the fiunding members of the Brain Somatic Mosaicism Network (BSMN), a multi-site consortium that studied somatic mosaicism and its implication for neuropsychiatric diseases. Vaccarino is a Fellow of American Association for the Advancement of Science and a member of the PsychENCODE the Somatic Mosaicism across Human Tissues ( SMaHT) Consortia.\",\"url\":\"https://medicine.yale.edu/profile/flora-vaccarino/\",\"email\":\"flora.vaccarino@yale.edu\",\"telephone\":\"+12037374147\",\"image\":{\"@type\":\"ImageObject\",\"url\":\"https://ysm-res.cloudinary.com/image/upload/c_limit,f_auto,h_630,q_auto,w_1200/v1/yms/prod/35647f85-7587-4df1-8e91-c3a764ccd6cb\",\"description\":\"2024-09-30-Flora-Vaccarino-\",\"height\":1200,\"width\":630,\"@context\":\"http://schema.org\"},\"address\":[],\"workLocation\":[],\"honorificSuffix\":[\"MD\"],\"award\":[],\"jobTitle\":[\"Harris Professor in the Child Study Center\"],\"affiliation\":[{\"@type\":\"Organization\",\"name\":\"Center for Brain & Mind Health\",\"url\":\"https://medicine.yale.edu/brain-mind-health/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Child & Adolescent Psychiatry Training Program\",\"url\":\"https://medicine.yale.edu/childstudy/education-and-training/clinical-internships-residencies-and-fellowships/child-and-adolescent-psychiatry-fellowship/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Child Study Center\",\"url\":\"https://medicine.yale.edu/childstudy/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Embryonic Stem Cell Research Oversight\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Interdepartmental Neuroscience Program\",\"url\":\"https://medicine.yale.edu/inp/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Kavli Institute for Neuroscience\",\"url\":\"https://medicine.yale.edu/kavli/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Neuroscience\",\"url\":\"https://medicine.yale.edu/neuroscience/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Neuroscience Track\",\"url\":\"https://medicine.yale.edu/bbs/tracks/neuroscience/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Program in Neurodevelopment and Regeneration\",\"url\":\"https://medicine.yale.edu/neurodevelopment/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Tic Disorder & Obsessive Compulsive Disorder Program\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Vaccarino Lab\",\"url\":\"https://medicine.yale.edu/lab/vaccarino/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"WHRY Pilot Project Program Investigators\",\"url\":\"https://medicine.yale.edu/whr/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Women's Health Research at Yale\",\"url\":\"https://medicine.yale.edu/whr/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Wu Tsai Institute\",\"url\":\"https://wti.yale.edu/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Center for Genomic Health\",\"url\":\"https://medicine.yale.edu/ycgh/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Combined Program in the Biological and Biomedical Sciences (BBS)\",\"url\":\"https://medicine.yale.edu/bbs/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Stem Cell Center\",\"url\":\"https://medicine.yale.edu/stemcell/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Ventures\",\"url\":\"https://ventures.yale.edu/\",\"@context\":\"http://schema.org\"}],\"alumniOf\":[{\"@type\":\"Organization\",\"name\":\"Yale University, School of Medicine, Psychiatry (1991)\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"FIDIA-Georgetown Institute for the Neurosciences (1987)\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"NIMH-Laboratory of Preclinical Pharmacology (1985)\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Padua University Medical University (1979)\",\"@context\":\"http://schema.org\"}],\"sameAs\":[],\"@context\":\"http://schema.org\"}],\"description\":\"Mato-Blanco X, Kim SK, Jourdon A, Ma S, Tebbenkamp ATN, Liu F, Duque A, Vaccarino FM, Sestan N, Colantuoni C, Rakic P, Santpere G, Micali N. Early Developmental Origins of Cortical Disorders Modeled in Human Neural Stem Cells. BioRxiv 2024 <a href=\\\"https://pubmed.ncbi.nlm.nih.gov/38915580\\\" target=\\\"_blank\\\">PMID: 38915580</a>, DOI: 10.1101/2024.06.14.598925.\",\"@context\":\"http://schema.org\"}"},{"schemaName":"MedicalScholarlyArticle","jsonData":"{\"@type\":\"MedicalScholarlyArticle\",\"publicationType\":\"Journal Article\",\"inLanguage\":\"en-US\",\"headline\":\"Massively parallel characterization of regulatory elements in the developing human cortex\",\"url\":\"https://pubmed.ncbi.nlm.nih.gov/38781390\",\"author\":[{\"@type\":\"Person\",\"name\":\"Flora Vaccarino\",\"description\":\"Flora Vaccarino is the Harris Professor at the Child Study Center and Professor in the Department of Neuroscience at Yale University. She received her MD from the University of Padova in Italy. She spent few years as Neuropharmacology Fellow at NIH, trained in clinical psychiatry at Yale, and then was a Research Fellow in developmental genetics at the Yale School of Medicine, where she raised through the ranks to Assistant, Associate and full Professor. Vaccarino leads a multidisciplinary research group working towards new directions for the study of mammalian brain development, particularly human, using stem cell biology and genomics as tools. She has been studying brain development in animal models for over 20 years, focusing on the role of growth factor receptor signaling in the regulation of stem cell behavior and cerebral cortex morphogenesis. Inspired by Sasai’s work, Vaccarino and her lab pioneered the generation of 3D brain organoids from induced pluripotent stem cells (iPSCs) in 2012, and showed that they recapitulate early fetal development of the human cerebral cortex. They then performed an extensive comparison of the organoid’s transcriptome and noncoding elements with isogenic postmortem human fetal cortex and characterized gene regulatory mechanisms that shape the earliest cell fate decisions in human cortical development. Her lab has generated an extensive collection of patient-derived iPSC lines to study altered gene regulatory mechanisms in Autism Spectrum Disorders. Her interests include human somatic genomic variation as a tool to study lineage specification in human embryonic development. She was one of the fiunding members of the Brain Somatic Mosaicism Network (BSMN), a multi-site consortium that studied somatic mosaicism and its implication for neuropsychiatric diseases. Vaccarino is a Fellow of American Association for the Advancement of Science and a member of the PsychENCODE the Somatic Mosaicism across Human Tissues ( SMaHT) Consortia.\",\"url\":\"https://medicine.yale.edu/profile/flora-vaccarino/\",\"email\":\"flora.vaccarino@yale.edu\",\"telephone\":\"+12037374147\",\"image\":{\"@type\":\"ImageObject\",\"url\":\"https://ysm-res.cloudinary.com/image/upload/c_limit,f_auto,h_630,q_auto,w_1200/v1/yms/prod/35647f85-7587-4df1-8e91-c3a764ccd6cb\",\"description\":\"2024-09-30-Flora-Vaccarino-\",\"height\":1200,\"width\":630,\"@context\":\"http://schema.org\"},\"address\":[],\"workLocation\":[],\"honorificSuffix\":[\"MD\"],\"award\":[],\"jobTitle\":[\"Harris Professor in the Child Study Center\"],\"affiliation\":[{\"@type\":\"Organization\",\"name\":\"Center for Brain & Mind Health\",\"url\":\"https://medicine.yale.edu/brain-mind-health/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Child & Adolescent Psychiatry Training 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Fullard J, Galani K, Galeev T, Gandal M, Gaynor S, Gerstein M, Geschwind D, Girdhar K, Goes F, Greenleaf W, Grundman J, Guo H, Guo Q, Gupta C, Hadas Y, Hallmayer J, Han X, Haroutunian V, Hawken N, He C, Henry E, Hicks S, Ho M, Ho L, Hoffman G, Huang Y, Huuki-Myers L, Hwang A, Hyde T, Iatrou A, Inoue F, Jajoo A, Jensen M, Jiang L, Jin P, Jin T, Jops C, Jourdon A, Kawaguchi R, Kellis M, Khullar S, Kleinman J, Kleopoulos S, Kozlenkov A, Kriegstein A, Kundaje A, Kundu S, Lee C, Lee D, Li J, Li M, Lin X, Liu S, Liu J, Liu J, Liu C, Liu S, Lou S, Loupe J, Lu D, Ma S, Ma L, Margolis M, Mariani J, Martinowich K, Maynard K, Mazariegos S, Meng R, Myers R, Micallef C, Mikhailova T, Ming G, Mohammadi S, Monte E, Montgomery K, Moore J, Moran J, Mukamel E, Nairn A, Nemeroff C, Ni P, Norton S, Nowakowski T, Omberg L, Page S, Park S, Patowary A, Pattni R, Pertea G, Peters M, Phalke N, Pinto D, Pjanic M, Pochareddy S, Pollard K, Pollen A, Pratt H, Przytycki P, Purmann C, Qin Z, Qu P, Quintero D, Raj T, Rajagopalan A, Reach S, Reimonn T, Ressler K, Ross D, Roussos P, Rozowsky J, Ruth M, Ruzicka W, Sanders S, Schneider J, Scuderi S, Sebra R, Sestan N, Seyfried N, Shao Z, Shedd N, Shieh A, Shin J, Skarica M, Snijders C, Song H, State M, Stein J, Steyert M, Subburaju S, Sudhof T, Snyder M, Tao R, Therrien K, Tsai L, Urban A, Vaccarino F, van Bakel H, Vo D, Voloudakis G, Wamsley B, Wang T, Wang S, Wang D, Wang Y, Warrell J, Wei Y, Weimer A, Weinberger D, Wen C, Weng Z, Whalen S, White K, Willsey A, Won H, Wong W, Wu H, Wu F, Wuchty S, Wylie D, Xu S, Yap C, Zeng B, Zhang P, Zhang C, Zhang B, Zhang J, Zhang Y, Zhou X, Ziffra R, Zeier Z, Zintel T. Massively parallel characterization of regulatory elements in the developing human cortex. Science 2024, 384: eadh0559. <a href=\\\"https://pubmed.ncbi.nlm.nih.gov/38781390\\\" target=\\\"_blank\\\">PMID: 38781390</a>, <a href=\\\"https://doi.org/10.1126/science.adh0559\\\" target=\\\"_blank\\\">DOI: 10.1126/science.adh0559</a>.\",\"@context\":\"http://schema.org\"}"},{"schemaName":"MedicalScholarlyArticle","jsonData":"{\"@type\":\"MedicalScholarlyArticle\",\"publicationType\":\"Journal Article\",\"inLanguage\":\"en-US\",\"headline\":\"Evaluating performance and applications of sample-wise cell deconvolution methods on human brain transcriptomi\",\"url\":\"https://pubmed.ncbi.nlm.nih.gov/38781336\",\"author\":[{\"@type\":\"Person\",\"name\":\"Flora Vaccarino\",\"description\":\"Flora Vaccarino is the Harris Professor at the Child Study Center and Professor in the Department of Neuroscience at Yale University. She received her MD from the University of Padova in Italy. She spent few years as Neuropharmacology Fellow at NIH, trained in clinical psychiatry at Yale, and then was a Research Fellow in developmental genetics at the Yale School of Medicine, where she raised through the ranks to Assistant, Associate and full Professor. Vaccarino leads a multidisciplinary research group working towards new directions for the study of mammalian brain development, particularly human, using stem cell biology and genomics as tools. She has been studying brain development in animal models for over 20 years, focusing on the role of growth factor receptor signaling in the regulation of stem cell behavior and cerebral cortex morphogenesis. Inspired by Sasai’s work, Vaccarino and her lab pioneered the generation of 3D brain organoids from induced pluripotent stem cells (iPSCs) in 2012, and showed that they recapitulate early fetal development of the human cerebral cortex. They then performed an extensive comparison of the organoid’s transcriptome and noncoding elements with isogenic postmortem human fetal cortex and characterized gene regulatory mechanisms that shape the earliest cell fate decisions in human cortical development. Her lab has generated an extensive collection of patient-derived iPSC lines to study altered gene regulatory mechanisms in Autism Spectrum Disorders. Her interests include human somatic genomic variation as a tool to study lineage specification in human embryonic development. She was one of the fiunding members of the Brain Somatic Mosaicism Network (BSMN), a multi-site consortium that studied somatic mosaicism and its implication for neuropsychiatric diseases. Vaccarino is a Fellow of American Association for the Advancement of Science and a member of the PsychENCODE the Somatic Mosaicism across Human Tissues ( SMaHT) Consortia.\",\"url\":\"https://medicine.yale.edu/profile/flora-vaccarino/\",\"email\":\"flora.vaccarino@yale.edu\",\"telephone\":\"+12037374147\",\"image\":{\"@type\":\"ImageObject\",\"url\":\"https://ysm-res.cloudinary.com/image/upload/c_limit,f_auto,h_630,q_auto,w_1200/v1/yms/prod/35647f85-7587-4df1-8e91-c3a764ccd6cb\",\"description\":\"2024-09-30-Flora-Vaccarino-\",\"height\":1200,\"width\":630,\"@context\":\"http://schema.org\"},\"address\":[],\"workLocation\":[],\"honorificSuffix\":[\"MD\"],\"award\":[],\"jobTitle\":[\"Harris Professor in the Child Study Center\"],\"affiliation\":[{\"@type\":\"Organization\",\"name\":\"Center for Brain & Mind Health\",\"url\":\"https://medicine.yale.edu/brain-mind-health/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Child & Adolescent Psychiatry Training Program\",\"url\":\"https://medicine.yale.edu/childstudy/education-and-training/clinical-internships-residencies-and-fellowships/child-and-adolescent-psychiatry-fellowship/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Child Study Center\",\"url\":\"https://medicine.yale.edu/childstudy/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Embryonic Stem Cell Research Oversight\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Interdepartmental Neuroscience Program\",\"url\":\"https://medicine.yale.edu/inp/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Kavli Institute for Neuroscience\",\"url\":\"https://medicine.yale.edu/kavli/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Neuroscience\",\"url\":\"https://medicine.yale.edu/neuroscience/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Neuroscience Track\",\"url\":\"https://medicine.yale.edu/bbs/tracks/neuroscience/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Program in Neurodevelopment and Regeneration\",\"url\":\"https://medicine.yale.edu/neurodevelopment/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Tic Disorder & Obsessive Compulsive Disorder Program\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Vaccarino Lab\",\"url\":\"https://medicine.yale.edu/lab/vaccarino/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"WHRY Pilot Project Program Investigators\",\"url\":\"https://medicine.yale.edu/whr/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Women's Health Research at Yale\",\"url\":\"https://medicine.yale.edu/whr/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Wu Tsai Institute\",\"url\":\"https://wti.yale.edu/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Center for Genomic Health\",\"url\":\"https://medicine.yale.edu/ycgh/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Combined Program in the Biological and Biomedical Sciences (BBS)\",\"url\":\"https://medicine.yale.edu/bbs/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Stem Cell Center\",\"url\":\"https://medicine.yale.edu/stemcell/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Ventures\",\"url\":\"https://ventures.yale.edu/\",\"@context\":\"http://schema.org\"}],\"alumniOf\":[{\"@type\":\"Organization\",\"name\":\"Yale University, School of Medicine, Psychiatry (1991)\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"FIDIA-Georgetown Institute for the Neurosciences (1987)\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"NIMH-Laboratory of Preclinical Pharmacology (1985)\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Padua University Medical University (1979)\",\"@context\":\"http://schema.org\"}],\"sameAs\":[],\"@context\":\"http://schema.org\"}],\"description\":\"Dai R, Chu T, Zhang M, Wang X, Jourdon A, Wu F, Mariani J, Vaccarino F, Lee D, Fullard J, Hoffman G, Roussos P, Wang Y, Wang X, Pinto D, Wang S, Zhang C, consortium P, Chen C, Liu C. Evaluating performance and applications of sample-wise cell deconvolution methods on human brain transcriptomic data. Science Advances 2024, 10: eadh2588. <a href=\\\"https://pubmed.ncbi.nlm.nih.gov/38781336\\\" target=\\\"_blank\\\">PMID: 38781336</a>, <a href=\\\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11114236\\\" target=\\\"_blank\\\">PMCID: PMC11114236</a>, <a href=\\\"https://doi.org/10.1126/sciadv.adh2588\\\" target=\\\"_blank\\\">DOI: 10.1126/sciadv.adh2588</a>.\",\"@context\":\"http://schema.org\"}"},{"schemaName":"MedicalScholarlyArticle","jsonData":"{\"@type\":\"MedicalScholarlyArticle\",\"publicationType\":\"Journal Article\",\"inLanguage\":\"en-US\",\"headline\":\"Specification of human regional brain lineages using orthogonal gradients of WNT and SHH in organoids.\",\"url\":\"https://pubmed.ncbi.nlm.nih.gov/38798404\",\"author\":[{\"@type\":\"Person\",\"name\":\"Flora Vaccarino\",\"description\":\"Flora Vaccarino is the Harris Professor at the Child Study Center and Professor in the Department of Neuroscience at Yale University. She received her MD from the University of Padova in Italy. She spent few years as Neuropharmacology Fellow at NIH, trained in clinical psychiatry at Yale, and then was a Research Fellow in developmental genetics at the Yale School of Medicine, where she raised through the ranks to Assistant, Associate and full Professor. Vaccarino leads a multidisciplinary research group working towards new directions for the study of mammalian brain development, particularly human, using stem cell biology and genomics as tools. She has been studying brain development in animal models for over 20 years, focusing on the role of growth factor receptor signaling in the regulation of stem cell behavior and cerebral cortex morphogenesis. Inspired by Sasai’s work, Vaccarino and her lab pioneered the generation of 3D brain organoids from induced pluripotent stem cells (iPSCs) in 2012, and showed that they recapitulate early fetal development of the human cerebral cortex. They then performed an extensive comparison of the organoid’s transcriptome and noncoding elements with isogenic postmortem human fetal cortex and characterized gene regulatory mechanisms that shape the earliest cell fate decisions in human cortical development. Her lab has generated an extensive collection of patient-derived iPSC lines to study altered gene regulatory mechanisms in Autism Spectrum Disorders. Her interests include human somatic genomic variation as a tool to study lineage specification in human embryonic development. She was one of the fiunding members of the Brain Somatic Mosaicism Network (BSMN), a multi-site consortium that studied somatic mosaicism and its implication for neuropsychiatric diseases. Vaccarino is a Fellow of American Association for the Advancement of Science and a member of the PsychENCODE the Somatic Mosaicism across Human Tissues ( SMaHT) Consortia.\",\"url\":\"https://medicine.yale.edu/profile/flora-vaccarino/\",\"email\":\"flora.vaccarino@yale.edu\",\"telephone\":\"+12037374147\",\"image\":{\"@type\":\"ImageObject\",\"url\":\"https://ysm-res.cloudinary.com/image/upload/c_limit,f_auto,h_630,q_auto,w_1200/v1/yms/prod/35647f85-7587-4df1-8e91-c3a764ccd6cb\",\"description\":\"2024-09-30-Flora-Vaccarino-\",\"height\":1200,\"width\":630,\"@context\":\"http://schema.org\"},\"address\":[],\"workLocation\":[],\"honorificSuffix\":[\"MD\"],\"award\":[],\"jobTitle\":[\"Harris Professor in the Child Study Center\"],\"affiliation\":[{\"@type\":\"Organization\",\"name\":\"Center for Brain & Mind Health\",\"url\":\"https://medicine.yale.edu/brain-mind-health/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Child & Adolescent Psychiatry Training Program\",\"url\":\"https://medicine.yale.edu/childstudy/education-and-training/clinical-internships-residencies-and-fellowships/child-and-adolescent-psychiatry-fellowship/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Child Study Center\",\"url\":\"https://medicine.yale.edu/childstudy/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Embryonic Stem Cell Research Oversight\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Interdepartmental Neuroscience Program\",\"url\":\"https://medicine.yale.edu/inp/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Kavli Institute for Neuroscience\",\"url\":\"https://medicine.yale.edu/kavli/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Neuroscience\",\"url\":\"https://medicine.yale.edu/neuroscience/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Neuroscience Track\",\"url\":\"https://medicine.yale.edu/bbs/tracks/neuroscience/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Program in Neurodevelopment and Regeneration\",\"url\":\"https://medicine.yale.edu/neurodevelopment/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Tic Disorder & Obsessive Compulsive Disorder Program\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Vaccarino Lab\",\"url\":\"https://medicine.yale.edu/lab/vaccarino/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"WHRY Pilot Project Program Investigators\",\"url\":\"https://medicine.yale.edu/whr/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Women's Health Research at Yale\",\"url\":\"https://medicine.yale.edu/whr/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Wu Tsai Institute\",\"url\":\"https://wti.yale.edu/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Center for Genomic Health\",\"url\":\"https://medicine.yale.edu/ycgh/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Combined Program in the Biological and Biomedical Sciences (BBS)\",\"url\":\"https://medicine.yale.edu/bbs/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Stem Cell Center\",\"url\":\"https://medicine.yale.edu/stemcell/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Ventures\",\"url\":\"https://ventures.yale.edu/\",\"@context\":\"http://schema.org\"}],\"alumniOf\":[{\"@type\":\"Organization\",\"name\":\"Yale University, School of Medicine, Psychiatry (1991)\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"FIDIA-Georgetown Institute for the Neurosciences (1987)\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"NIMH-Laboratory of Preclinical Pharmacology (1985)\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Padua University Medical University (1979)\",\"@context\":\"http://schema.org\"}],\"sameAs\":[],\"@context\":\"http://schema.org\"}],\"description\":\"Scuderi S, Kang TY, Jourdon A, Yang L, Wu F, Nelson A, Anderson GM, Mariani J, Sarangi V, Abyzov A, Levchenko A, Vaccarino FM. Specification of human regional brain lineages using orthogonal gradients of WNT and SHH in organoids. 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She received her MD from the University of Padova in Italy. She spent few years as Neuropharmacology Fellow at NIH, trained in clinical psychiatry at Yale, and then was a Research Fellow in developmental genetics at the Yale School of Medicine, where she raised through the ranks to Assistant, Associate and full Professor. Vaccarino leads a multidisciplinary research group working towards new directions for the study of mammalian brain development, particularly human, using stem cell biology and genomics as tools. She has been studying brain development in animal models for over 20 years, focusing on the role of growth factor receptor signaling in the regulation of stem cell behavior and cerebral cortex morphogenesis. Inspired by Sasai’s work, Vaccarino and her lab pioneered the generation of 3D brain organoids from induced pluripotent stem cells (iPSCs) in 2012, and showed that they recapitulate early fetal development of the human cerebral cortex. They then performed an extensive comparison of the organoid’s transcriptome and noncoding elements with isogenic postmortem human fetal cortex and characterized gene regulatory mechanisms that shape the earliest cell fate decisions in human cortical development. Her lab has generated an extensive collection of patient-derived iPSC lines to study altered gene regulatory mechanisms in Autism Spectrum Disorders. Her interests include human somatic genomic variation as a tool to study lineage specification in human embryonic development. She was one of the fiunding members of the Brain Somatic Mosaicism Network (BSMN), a multi-site consortium that studied somatic mosaicism and its implication for neuropsychiatric diseases. Vaccarino is a Fellow of American Association for the Advancement of Science and a member of the PsychENCODE the Somatic Mosaicism across Human Tissues ( SMaHT) Consortia.<br /></p>","workdayTitle":"Harris Professor in the Child Study Center","yaleCustomTitles":["Director, Program in Neurodevelopment and Regeneration, Child Study Center","Professor in the Department of Neuroscience"],"nonYaleCustomTitles":[],"labWebsite":null,"cvUrl":"https://beatrix.yale.edu/api/people/profiles/59481/public-cv/download","ymProfileUrl":null,"boardCertifications":[],"appointments":[{"id":58907,"title":"Professor","type":"Primary","organizationName":"Child Study Center","websiteUrl":"https://medicine.yale.edu/childstudy/"},{"id":104092,"title":"Professor","type":"Secondary","organizationName":"Neuroscience","websiteUrl":"https://medicine.yale.edu/neuroscience/"}],"organizations":[{"id":121620,"name":"Center for Brain & Mind Health","url":"https://medicine.yale.edu/brain-mind-health/"},{"id":109846,"name":"Child & Adolescent Psychiatry Training Program","url":"https://medicine.yale.edu/childstudy/education-and-training/clinical-internships-residencies-and-fellowships/child-and-adolescent-psychiatry-fellowship/"},{"id":108736,"name":"Child Study Center","url":"https://medicine.yale.edu/childstudy/"},{"id":109835,"name":"Embryonic Stem Cell Research Oversight","url":null},{"id":109560,"name":"Interdepartmental Neuroscience Program","url":"https://medicine.yale.edu/inp/"},{"id":109402,"name":"Kavli Institute for Neuroscience","url":"https://medicine.yale.edu/kavli/"},{"id":108862,"name":"Neuroscience","url":"https://medicine.yale.edu/neuroscience/"},{"id":109537,"name":"Neuroscience Track","url":"https://medicine.yale.edu/bbs/tracks/neuroscience/"},{"id":110305,"name":"Program in Neurodevelopment and Regeneration","url":"https://medicine.yale.edu/neurodevelopment/"},{"id":109219,"name":"Tic Disorder & Obsessive Compulsive Disorder Program","url":null},{"id":115587,"name":"Vaccarino Lab","url":"https://medicine.yale.edu/lab/vaccarino/"},{"id":115457,"name":"WHRY Pilot Project Program Investigators","url":"https://medicine.yale.edu/whr/"},{"id":109460,"name":"Women's Health Research at Yale","url":"https://medicine.yale.edu/whr/"},{"id":121945,"name":"Wu Tsai Institute","url":"https://wti.yale.edu/"},{"id":119354,"name":"Yale Center for Genomic Health","url":"https://medicine.yale.edu/ycgh/"},{"id":109532,"name":"Yale Combined Program in the Biological and Biomedical Sciences (BBS)","url":"https://medicine.yale.edu/bbs/"},{"id":109569,"name":"Yale Stem Cell Center","url":"https://medicine.yale.edu/stemcell/"},{"id":114820,"name":"Yale Ventures","url":"https://ventures.yale.edu/"}],"educations":[{"degree":"Resident","institution":"Yale University, School of Medicine, Psychiatry (1991)","dateAwarded":"1991-01-01T00:00:00Z","isTraining":true},{"degree":"Visiting Assistant Professor","institution":"FIDIA-Georgetown Institute for the Neurosciences (1987)","dateAwarded":"1987-01-01T00:00:00Z","isTraining":true},{"degree":"Research Fellow","institution":"NIMH-Laboratory of Preclinical Pharmacology (1985)","dateAwarded":"1985-01-01T00:00:00Z","isTraining":true},{"degree":"MD","institution":"Padua University Medical University (1979)","dateAwarded":"1979-01-01T00:00:00Z","isTraining":false}],"advancedTrainings":[],"sectionType":"about"},{"config":{"layoutType":"default","statement":null,"quote":null,"stats":{"clinicalTrialInfo":null,"publicationInfo":{"publicationsCount":169,"citationsCount":10304,"coAuthorsCount":48,"searchUrl":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino"}}},"displayMode":"default","pageName":"flora-vaccarino","fullName":"Flora Vaccarino","researchDescription":"<p>The Vaccarino laboratory has elucidated crucial mechanisms that regulate neural stem cell self-renewal, survival and differentiation. The lab has been examining conserved mechanisms of forebrain development using mouse models, and human-specific mechanisms by examining human stem and progenitor cells. Using induced pluripotent cells (iPSC) derived from living individuals, the Vaccarino group is now examining how human stem cell differentiation varies across different genetic backgrounds, sex, and clinical phenotypes. </p> <p> In the 1990’s Vaccarino and colleagues reported that an extracellular protein called <strong>Basic Fibroblast Growth Factor 2 (FGF2) </strong>increases the number of progenitors for excitatory cortical neurons in vitro (<a href=\"https://www.ncbi.nlm.nih.gov/pubmed/7719131\">Vaccarino et al., 1995</a>) and in vivo, by microinjection of FGF2 into the cerebral ventricles of rat embryos, producing an increase in cortical surface area (<a href=\"https://pubmed.ncbi.nlm.nih.gov/10195217/\">Vaccarino et al., 1999</a>). This was the first evidence that a single factor can elicit a permanent increase in pyramidal neuron number and cerebral cortical size in a mammalian species. Subsequent work demonstrated that the FGF ligands (Vaccarino et al., 1999; Raballo et al., 2000; Korada et al., 2002) and FGF receptors are essential for normal telencephalic development in a region-specific fashion. The Fgfr1 gene knockout alone thwarts cell proliferation within the hippocampal primordium, causing lifelong hippocampal atrophy (Ohkubo et al., 2004), and the double knockout of Fgfr1 and Fgfr2 causes prefrontal cortex volume loss with fewer pyramidal cells (Stevens et al, 2010). Finally, the combined knockout of Fgfr1, Fgfr2 and Fgfr3 in early neurogenesis depletes the cortical stem cell pool globally, resulting in premature ending of neurogenesis and decreased cortical surface area (<a href=\"http://www.ncbi.nlm.nih.gov/pubmed/22031906\">Rash et al, 2011</a>). Conversely, a microinjection of FGF2 in the lateral ventricles at pre-neurogenic stages of cortical development generates a massive enlargement of frontal cortical surface and the appearance of gyrus-like convolutions in stereotypic bilateral locations (<a href=\"http://www.ncbi.nlm.nih.gov/pubmed/23804101\">Rash et al, 2013</a>). </p> <p>In summary, our studies have shown that FGFs establish the primary structure and the surface area of the cerebral cortex by promoting the self-renewal of neural stem cells and the differentiation of projection neurons from neuroepithelial precursors. </p> <p>The lab has also examined the roles of FGFs in astroglial cells—diverse cellular elements that evolve from a primary role of neural progenitors during embryonic development, to essential partners in neuronal migration, maturation, and metabolic support in the adult brain. To study astroglial cells, the lab has generated the GFAP-CreERT2 transgenic line, in which the Cre recombinase can be transiently induced by a tamoxifen injection in GFAP+ astroglial cells (Ganat et al, 2006). By marking GFAP+ astroglial cells via recombination of genetic reporters, we found that astrocytes can produce neurons in the immature brain, a process that is enhanced by hypoxic injury (Fagel et al., 2006, and Fagel et al, 2009; Bi et al, 2011) and dependent in part upon FGF receptor function (Fagel et al, 2009; Stevens et al, 2102). Furthermore, FGF receptors are required in astroglia to indirectly promote the maturation of cortical inhibitory interneurons during early postnatal development (Müller Smith et al, 2014). Induced loss of FGF signaling only in postnatal astrocytes generates stereotypic locomotor hyperactivity and learning and memory defects that correlate with deficit in specific cell populations in the postnatal brain (Müller Smith et al, 2008, Stevens et al, 2012). </p> <p> Conscious of the profound differences between brain development in rodents and primates, the Vaccarino lab has been pursuing parallel<strong> studies of the human brain</strong>. A major theme is whether an excitatory/inhibitory neuron imbalance in specific forebrain systems due to disparate etiologies (i.e., gene mutations; prenatal factors; environmental noxae) may predispose to neuropsychiatric disorders such as autism and Tourette syndrome. </p> <p>Through <strong>postmortem studies of patient and control brains</strong>, the lab has discovered in landmark studies that individuals with Tourette’s syndrome (TS) have losses of GABAergic and cholinergic interneurons in the striatum. TS is a developmental disorder of childhood characterized by motor and vocal tics. We demonstrated a large decrease in three classes of interneurons in the striatum of TS: Parvalbumin+; NOS+/NPY+/SST+; and cholinergic (<a href=\"http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16131542\">Kalanithi et al, 2005</a>; <a href=\"http://www.ncbi.nlm.nih.gov/pubmed/19941350\">Kataoka et al, 2010</a>). RNA sequencing confirmed the decreased in interneuron transcripts, and also revealed an up-regulation of inflammatory response- and immune system-related genes (Lennington et al., 2014). The hypothesis is that altered development of subsets of inhibitory neurons in cortico-basal ganglia circuits causes specific alterations in neuronal firing that may cause disorders of the TS spectrum. Current studies using iPSC-derived basal ganglia organoids confirm thwarted development of inhibitory and cholinergic interneurons in TS and suggest potential pathophysiological mechanisms (see below). </p> <p>To model disorders of brain development in a human system, the Vaccarino lab has adopted the <strong>induced pluripotent stem cell (iPSC)</strong> model and over the last several years has derived over 600 iPSC lines from patients with developmental disorders. Vaccarino and colleagues pioneered the generation of cortical organoids from iPSC lines (Mariani et al, 2012) and contributed fundamental work on neurodevelopmental alterations in severe, idiopathic ASD using this tool. Transcriptome and cell fate studies in organoids from individuals affected with ASD as compared to unaffected family members indicated alterations in cell proliferation, overproduction of synapses and a striking imbalance between inhibitory and excitatory neurons and their precursors (Mariani et al, Cell, 2015). The work has also revealed an important role of the transcription factor FOXG1 in the overproduction of GABAegic precursor cells (<a href=\"http://www.ncbi.nlm.nih.gov/pubmed/26186191\">Mariani et al, 2015</a>). </p> <p>Other studies integrated genomes, transcriptomes and cellular phenotypes to better characterize the organoids as a model for brain development. As part of the <strong><a href=\"http://psychencode.org/\">PsychENCODE</a> collaborative multi-site project, </strong>the lab generated a genome-scale catalog of transcripts and regulatory DNA elements, primarily enhancers, in iPSC-derived organoids and human brain specimens of the same genetic background. The work established that cortical organoids reflect the human cerebral cortex at embryonic to early fetal stages of human brain development, and display a large repertoire of active enhancers that control early neuronal fate and differentiation (<a href=\"https://pubmed.ncbi.nlm.nih.gov/30545853/\">Amiri et al, 2018</a>). </p> <p>Current studies are using single cell approaches to characterize brain organoids in people with different genetic background and in patients with ASD and Tourette syndrome, integrating gene expression with gene regulatory elements and chromatin architecture. </p> <p>In recent years, <strong>somatic mosaicism</strong> has emerged as a potential source of differences in developmental trajectories among individuals. Somatic mosaicism is the accumulation of mutations in cellular genomes after fertilization. These can be variations in DNA sequence, including single nucleotide variations (SNVs) and small insertions/deletions (Indels), or variations in DNA copy number (CNVs), in the form of large duplication/deletions. The notion that cells in an individual organism do not share the same genome is not new, but only in the last decade the scientific community has begun to use emerging deep sequencing technologies to understand the scale of this phenomenon. Somatic mutations are present in both normal cells and in various diseases (Jourdon et al, 2020) and somatic variation has been suggested to play a role in driving neuronal diversity and genome evolution. We collaborate closely with the computational genomics laboratory of Alexej Abyzov at the Mayo Clinic. Together, we have demonstrated and quantified widespread somatic mosaicism in many human cell types and tissues, including human skin fibrolasts (<a href=\"https://pubmed.ncbi.nlm.nih.gov/23160490/\">Abyzov et al, Nature, 2012</a>; <a href=\"https://genome.cshlp.org/content/early/2017/03/20/gr.215517.116\">Abyzov et al, Genome Research, 2017</a>; <a href=\"http://pubmed.ncbi.nlm.nih.gov/33737484/\" title=\"Fasching et al, Science, 2021\">Fasching et al, Science, 2021</a>) and the human developing brain (<a href=\"https://science.sciencemag.org/content/359/6375/550\">Bae et al, Science, 2018</a>). </p> <p>We were founding members of the <strong>Brain Somatic Mosaicism (BSMN) <a href=\"https://staging.bsmn.synapse.org/\">network</a>, </strong>sponsored by the National Institute of Mental Health (NIMH) and encompassing laboratories from several major centers in the US. We are active members of the <strong>Somatic Mosaisism across Human Tissues (SMaHT) </strong>consortium, which aims at generating a catalog of somatic genomic variants in several tissue across the human body and brain.</p> <p>Using postmortem tissue, our group was the first to use retrospective somatic mutations to delineate a lineage map for the early human embryo, which suggested that a mosaic single nucleotide variant (SNV) is generated at each cell division (rate: 1.3 SNVs/cell/mitosis) (<a href=\"https://science.sciencemag.org/content/359/6375/550\">Bae et al, Science, 2018</a>). Since then, we determined that lineage reconstruction can be done in living persons, opening the possibility of using routine lineage reconstruction for understanding individual differences in development, as well as early diagnosis of many medical conditions involving lineage asymmetry and clonal expansion due to MM, including cancer and epilepsy (<a href=\"http://pubmed.ncbi.nlm.nih.gov/33737484/\" title=\"Fasching et al, Science, 2021\">Fasching et al, Science, 2021</a>). </p> <p>Our current work seeks to develop a comprehensive yet minimally invasive approach, including experimental procedures and computational methods, for generating individualized lineage and mosaicism maps. If successful, it could provide a fundamental shift in clinical practice from considering just the individual germline genome to considering the germline genome along with the individual lineage and mosaicism maps and, perhaps, updating these maps over an individual’s lifetime. </p> <p></p>","meshKeywords":[{"id":27608,"keyword":"Autism Spectrum Disorder"},{"id":1255,"keyword":"Autistic Disorder"},{"id":17738,"keyword":"Cell Lineage"},{"id":2376,"keyword":"Central Nervous System Diseases"},{"id":14799,"keyword":"Developmental Biology"},{"id":28814,"keyword":"Human Genetics"},{"id":25380,"keyword":"Induced Pluripotent Stem Cells"},{"id":18111,"keyword":"Living Donors"},{"id":8423,"keyword":"Mice, Inbred Strains"},{"id":8430,"keyword":"Mice, Transgenic"},{"id":8628,"keyword":"Mosaicism"},{"id":26011,"keyword":"Neural Stem Cells"},{"id":9026,"keyword":"Neuroanatomy"},{"id":29000,"keyword":"Neurodevelopmental Disorders"},{"id":9066,"keyword":"Neurosciences"},{"id":9503,"keyword":"Organoids"},{"id":9909,"keyword":"Patients"},{"id":27460,"keyword":"Psychiatry and Psychology"},{"id":11519,"keyword":"Regeneration"},{"id":12015,"keyword":"Schizophrenia"},{"id":5628,"keyword":"Tourette Syndrome"}],"publicHealthKeywords":[],"publicationListing":{"collection":[{"category":"Peer-Reviewed Original Research","pubMedUid":39892689,"doi":null,"altmetricAttentionScore":0,"timesCited":0,"isFeatured":false,"keywords":[],"concepts":[],"id":"0^51726","title":"Interneuron loss and microglia activation by transcriptome analyses in the basal ganglia of Tourette disorder.","citation":"Wang Y, Fasching L, Wu F, Suvakov M, Huttner A, Berretta S, Roberts R, Leckman JF, Fernandez TV, Abyzov A, Vaccarino FM. Interneuron loss and microglia activation by transcriptome analyses in the basal ganglia of Tourette disorder. Biol Psychiatry 2025 <a href=\"https://pubmed.ncbi.nlm.nih.gov/39892689\" target=\"_blank\">PMID: 39892689</a>, DOI: 10.1016/j.biopsych.2024.12.022.","year":2025,"link":{"url":"https://pubmed.ncbi.nlm.nih.gov/39892689","text":"Interneuron loss and microglia activation by transcriptome analyses in the basal ganglia of Tourette disorder."}},{"category":"Chapters","pubMedUid":null,"doi":"10.1016/b978-0-443-19176-3.00044-3","altmetricAttentionScore":0,"timesCited":0,"isFeatured":false,"keywords":[],"concepts":[{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Tourette%20syndrome","text":"Tourette syndrome"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Cortico-striatal-thalamo-cortical%20circuitry","text":"Cortico-striatal-thalamo-cortical circuitry"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Striatal%20volume%20loss","text":"Striatal volume loss"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Adult%20TS%20patients","text":"Adult TS patients"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Neuroimaging%20studies","text":"Neuroimaging studies"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Neuropsychiatric%20disorders","text":"Neuropsychiatric disorders"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Dopaminergic%20receptors","text":"Dopaminergic receptors"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Vocal%20tics","text":"Vocal tics"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Striatal%20interneurons","text":"Striatal interneurons"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Classes%20of%20striatal%20interneurons","text":"Classes of striatal interneurons"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Basal%20ganglia","text":"Basal ganglia"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Metabolic%20hypofunction","text":"Metabolic hypofunction"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Environmental%20risk%20factors","text":"Environmental risk factors"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=TS%20patients","text":"TS patients"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Ameliorate%20symptoms","text":"Ameliorate symptoms"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Genetic%20contribution","text":"Genetic contribution"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Molecular%20abnormalities","text":"Molecular abnormalities"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Pharmacological%20strategies","text":"Pharmacological strategies"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Circuitry","text":"Circuitry"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Affecting%201","text":"Affecting 1"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Animal%20models","text":"Animal models"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Risk%20factors","text":"Risk factors"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Interneuronal%20circuitry","text":"Interneuronal circuitry"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Volume%20loss","text":"Volume loss"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Abnormalities","text":"Abnormalities"}],"id":"713051^0","title":"Chapter 53 Tourette syndrome","citation":"Abdallah S, Fasching L, Brady M, Bloch M, Lombroso P, Vaccarino F, Fernandez T. Chapter 53 Tourette syndrome. 2025, 951-962. <a href=\"https://doi.org/10.1016/b978-0-443-19176-3.00044-3\" target=\"_blank\">DOI: 10.1016/b978-0-443-19176-3.00044-3</a>.","year":2025,"link":{"url":"https://doi.org/10.1016/b978-0-443-19176-3.00044-3","text":"Chapter 53 Tourette syndrome"}},{"category":"Peer-Reviewed Original Research","pubMedUid":39653126,"doi":"10.1038/s41586-024-08487-6","altmetricAttentionScore":18,"timesCited":0,"isFeatured":false,"keywords":[],"concepts":[{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Data%20sharing","text":"Data sharing"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Cells%20in%20vitro","text":"Cells in vitro"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Human%20pluripotent%20stem%20cells","text":"Human pluripotent stem cells"}],"id":"716793^0","title":"A framework for neural organoids, assembloids and transplantation studies","citation":"Pașca S, Arlotta P, Bateup H, Camp J, Cappello S, Gage F, Knoblich J, Kriegstein A, Lancaster M, Ming G, Novarino G, Okano H, Parmar M, Park I, Reiner O, Song H, Studer L, Takahashi J, Temple S, Testa G, Treutlein B, Vaccarino F, Vanderhaeghen P, Young-Pearse T. A framework for neural organoids, assembloids and transplantation studies. Nature 2024, 1-3. <a href=\"https://pubmed.ncbi.nlm.nih.gov/39653126\" target=\"_blank\">PMID: 39653126</a>, <a href=\"https://doi.org/10.1038/s41586-024-08487-6\" target=\"_blank\">DOI: 10.1038/s41586-024-08487-6</a>.","year":2024,"link":{"url":"https://pubmed.ncbi.nlm.nih.gov/39653126","text":"A framework for neural organoids, assembloids and transplantation studies"}},{"category":"Peer-Reviewed Original Research","pubMedUid":39438473,"doi":"10.1038/s41467-024-53485-x","altmetricAttentionScore":1,"timesCited":0,"isFeatured":false,"keywords":[{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=311","text":"Adult"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=1671","text":"Blastomeres"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=17738","text":"Cell Lineage"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=5033","text":"Female"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=5603","text":"Germ Cells"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=16893","text":"Germ-Line Mutation"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=6498","text":"Humans"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=7926","text":"Male"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=8746","text":"Mutation"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=9923","text":"Pedigree"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=14428","text":"Zygote"}],"concepts":[{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Post-zygotic%20mutations","text":"Post-zygotic mutations"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Lineage%20allocation","text":"Lineage allocation"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Origin%20of%20germ%20cells","text":"Origin of germ cells"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Phenotypically%20normal%20woman","text":"Phenotypically normal woman"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Germ%20cells","text":"Germ cells"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Somatic%20tissues","text":"Somatic tissues"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Human%20germline","text":"Human germline"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Lineages","text":"Lineages"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Mutation%20transmission","text":"Mutation transmission"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Germline","text":"Germline"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Normal%20women","text":"Normal women"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Mutations","text":"Mutations"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Zygotic%20cleavage","text":"Zygotic cleavage"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Blastomeres","text":"Blastomeres"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Genome","text":"Genome"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Cells","text":"Cells"}],"id":"713796^0","title":"Transgenerational transmission of post-zygotic mutations suggests symmetric contribution of first two blastomeres to human germline","citation":"Jang Y, Tomasini L, Bae T, Szekely A, Vaccarino F, Abyzov A. Transgenerational transmission of post-zygotic mutations suggests symmetric contribution of first two blastomeres to human germline. Nature Communications 2024, 15: 9117. <a href=\"https://pubmed.ncbi.nlm.nih.gov/39438473\" target=\"_blank\">PMID: 39438473</a>, <a href=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11496613\" target=\"_blank\">PMCID: PMC11496613</a>, <a href=\"https://doi.org/10.1038/s41467-024-53485-x\" target=\"_blank\">DOI: 10.1038/s41467-024-53485-x</a>.","year":2024,"link":{"url":"https://pubmed.ncbi.nlm.nih.gov/39438473","text":"Transgenerational transmission of post-zygotic mutations suggests symmetric contribution of first two blastomeres to human germline"}},{"category":"Chapters","pubMedUid":null,"doi":null,"altmetricAttentionScore":0,"timesCited":0,"isFeatured":false,"keywords":[],"concepts":[],"id":"0^50843","title":"Tourette syndrome","citation":"Abdallah SB, Fasching L, Brady M, Bloch MH, Lombroso P, Vaccarino FM, Fernandez TV. Tourette syndrome. In: Rosenberg RN, Pascual JM, editors. Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease, Seventh Edition San Diego, CA: Elsevier/Academic Press; 2024. Chapter 53; p.951-962. ","year":2024,"link":null},{"category":"Peer-Reviewed Original Research","pubMedUid":39084540,"doi":"10.1016/j.bbi.2024.07.044","altmetricAttentionScore":1,"timesCited":1,"isFeatured":false,"keywords":[],"concepts":[{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Pediatric%20Autoimmune%20Neuropsychiatric%20Disorders%20Associated%20with%20Streptococcus","text":"Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Pediatric%20acute-onset%20neuropsychiatric%20syndrome","text":"Pediatric acute-onset neuropsychiatric syndrome"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Striatal%20cholinergic%20interneurons","text":"Striatal cholinergic interneurons"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Cholinergic%20interneurons","text":"Cholinergic interneurons"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Obsessive-compulsive%20symptoms","text":"Obsessive-compulsive symptoms"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Modulate%20basal%20ganglia%20function","text":"Modulate basal ganglia function"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Neuropsychiatric%20syndrome","text":"Neuropsychiatric syndrome"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Significant%20obsessive-compulsive%20symptoms","text":"Significant obsessive-compulsive symptoms"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Basal%20ganglia%20function","text":"Basal ganglia function"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Ex%20vivo%20brain%20slices","text":"Ex vivo brain slices"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Severe%20food%20restriction","text":"Severe food restriction"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Elevated%20antibodies","text":"Elevated antibodies"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Clinical%20history","text":"Clinical history"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Patient%20plasma","text":"Patient plasma"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Neuropsychiatric%20manifestations","text":"Neuropsychiatric manifestations"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Streptococcus%20infection","text":"Streptococcus infection"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Brain%20slices","text":"Brain slices"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Symptom%20flares","text":"Symptom flares"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Control%20plasma","text":"Control plasma"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Food%20restriction","text":"Food restriction"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Serum%20antibodies","text":"Serum antibodies"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Human%20brain","text":"Human brain"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Infection","text":"Infection"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Abrupt%20onset","text":"Abrupt onset"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&concept=Clinical%20context","text":"Clinical context"}],"id":"704878^0","title":"Elevated antibody binding to striatal cholinergic interneurons in patients with pediatric acute-onset neuropsychiatric syndrome","citation":"Xu J, Frankovich J, Liu R, Thienemann M, Silverman M, Farhadian B, Willett T, Manko C, Columbo L, Leibold C, Vaccarino F, Che A, Pittenger C. Elevated antibody binding to striatal cholinergic interneurons in patients with pediatric acute-onset neuropsychiatric syndrome. Brain Behavior And Immunity 2024, 122: 241-255. <a href=\"https://pubmed.ncbi.nlm.nih.gov/39084540\" target=\"_blank\">PMID: 39084540</a>, <a href=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11569416\" target=\"_blank\">PMCID: PMC11569416</a>, <a href=\"https://doi.org/10.1016/j.bbi.2024.07.044\" target=\"_blank\">DOI: 10.1016/j.bbi.2024.07.044</a>.","year":2024,"link":{"url":"https://pubmed.ncbi.nlm.nih.gov/39084540","text":"Elevated antibody binding to striatal cholinergic interneurons in patients with pediatric acute-onset neuropsychiatric syndrome"}},{"category":"Peer-Reviewed Original Research","pubMedUid":38915580,"doi":null,"altmetricAttentionScore":0,"timesCited":0,"isFeatured":false,"keywords":[],"concepts":[],"id":"0^50004","title":"Early Developmental Origins of Cortical Disorders Modeled in Human Neural Stem Cells.","citation":"Mato-Blanco X, Kim SK, Jourdon A, Ma S, Tebbenkamp ATN, Liu F, Duque A, Vaccarino FM, Sestan N, Colantuoni C, Rakic P, Santpere G, Micali N. Early Developmental Origins of Cortical Disorders Modeled in Human Neural Stem Cells. 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Massively parallel characterization of regulatory elements in the developing human cortex. Science 2024, 384: eadh0559. <a href=\"https://pubmed.ncbi.nlm.nih.gov/38781390\" target=\"_blank\">PMID: 38781390</a>, <a href=\"https://doi.org/10.1126/science.adh0559\" target=\"_blank\">DOI: 10.1126/science.adh0559</a>.","year":2024,"link":{"url":"https://pubmed.ncbi.nlm.nih.gov/38781390","text":"Massively parallel characterization of regulatory elements in the developing human cortex"}},{"category":"Peer-Reviewed Original Research","pubMedUid":38781336,"doi":"10.1126/sciadv.adh2588","altmetricAttentionScore":12,"timesCited":6,"isFeatured":false,"keywords":[{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=311","text":"Adult"},{"url":"/childstudy/profile/flora-vaccarino/academic-publications/?profilePageName=flora-vaccarino&keywordId=517","text":"Alzheimer 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Evaluating performance and applications of sample-wise cell deconvolution methods on human brain transcriptomic data. Science Advances 2024, 10: eadh2588. <a href=\"https://pubmed.ncbi.nlm.nih.gov/38781336\" target=\"_blank\">PMID: 38781336</a>, <a href=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11114236\" target=\"_blank\">PMCID: PMC11114236</a>, <a href=\"https://doi.org/10.1126/sciadv.adh2588\" target=\"_blank\">DOI: 10.1126/sciadv.adh2588</a>.","year":2024,"link":{"url":"https://pubmed.ncbi.nlm.nih.gov/38781336","text":"Evaluating performance and applications of sample-wise cell deconvolution methods on human brain transcriptomic data"}},{"category":"Peer-Reviewed Original Research","pubMedUid":38798404,"doi":null,"altmetricAttentionScore":0,"timesCited":0,"isFeatured":false,"keywords":[],"concepts":[],"id":"0^50005","title":"Specification of human regional brain lineages using orthogonal gradients of WNT and SHH in organoids.","citation":"Scuderi S, Kang TY, Jourdon A, Yang L, Wu F, Nelson A, Anderson GM, Mariani J, Sarangi V, Abyzov A, Levchenko A, Vaccarino FM. Specification of human regional brain lineages using orthogonal gradients of WNT and SHH in organoids. 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A framework for neural organoids, assembloids and transplantation studies. Nature 2024, 1-3. <a href=\\\"https://pubmed.ncbi.nlm.nih.gov/39653126\\\" target=\\\"_blank\\\">PMID: 39653126</a>, <a href=\\\"https://doi.org/10.1038/s41586-024-08487-6\\\" target=\\\"_blank\\\">DOI: 10.1038/s41586-024-08487-6</a>.\",\"@context\":\"http://schema.org\"}"},{"schemaName":"MedicalScholarlyArticle","jsonData":"{\"@type\":\"MedicalScholarlyArticle\",\"publicationType\":\"Journal Article\",\"inLanguage\":\"en-US\",\"headline\":\"Transgenerational transmission of post-zygotic mutations suggests symmetric contribution of first two blastome\",\"url\":\"https://pubmed.ncbi.nlm.nih.gov/39438473\",\"author\":[{\"@type\":\"Person\",\"name\":\"Flora Vaccarino\",\"description\":\"Flora Vaccarino is the Harris Professor at the Child Study Center and Professor in the Department of Neuroscience at Yale University. She received her MD from the University of Padova in Italy. 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They then performed an extensive comparison of the organoid’s transcriptome and noncoding elements with isogenic postmortem human fetal cortex and characterized gene regulatory mechanisms that shape the earliest cell fate decisions in human cortical development. Her lab has generated an extensive collection of patient-derived iPSC lines to study altered gene regulatory mechanisms in Autism Spectrum Disorders. Her interests include human somatic genomic variation as a tool to study lineage specification in human embryonic development. She was one of the fiunding members of the Brain Somatic Mosaicism Network (BSMN), a multi-site consortium that studied somatic mosaicism and its implication for neuropsychiatric diseases. Vaccarino is a Fellow of American Association for the Advancement of Science and a member of the PsychENCODE the Somatic Mosaicism across Human Tissues ( SMaHT) Consortia.\",\"url\":\"https://medicine.yale.edu/profile/flora-vaccarino/\",\"email\":\"flora.vaccarino@yale.edu\",\"telephone\":\"+12037374147\",\"image\":{\"@type\":\"ImageObject\",\"url\":\"https://ysm-res.cloudinary.com/image/upload/c_limit,f_auto,h_630,q_auto,w_1200/v1/yms/prod/35647f85-7587-4df1-8e91-c3a764ccd6cb\",\"description\":\"2024-09-30-Flora-Vaccarino-\",\"height\":1200,\"width\":630,\"@context\":\"http://schema.org\"},\"address\":[],\"workLocation\":[],\"honorificSuffix\":[\"MD\"],\"award\":[],\"jobTitle\":[\"Harris Professor in the Child Study Center\"],\"affiliation\":[{\"@type\":\"Organization\",\"name\":\"Center for Brain & Mind Health\",\"url\":\"https://medicine.yale.edu/brain-mind-health/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Child & Adolescent Psychiatry Training Program\",\"url\":\"https://medicine.yale.edu/childstudy/education-and-training/clinical-internships-residencies-and-fellowships/child-and-adolescent-psychiatry-fellowship/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Child Study Center\",\"url\":\"https://medicine.yale.edu/childstudy/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Embryonic Stem Cell Research Oversight\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Interdepartmental Neuroscience Program\",\"url\":\"https://medicine.yale.edu/inp/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Kavli Institute for Neuroscience\",\"url\":\"https://medicine.yale.edu/kavli/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Neuroscience\",\"url\":\"https://medicine.yale.edu/neuroscience/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Neuroscience Track\",\"url\":\"https://medicine.yale.edu/bbs/tracks/neuroscience/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Program in Neurodevelopment and Regeneration\",\"url\":\"https://medicine.yale.edu/neurodevelopment/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Tic Disorder & Obsessive Compulsive Disorder Program\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Vaccarino Lab\",\"url\":\"https://medicine.yale.edu/lab/vaccarino/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"WHRY Pilot Project Program Investigators\",\"url\":\"https://medicine.yale.edu/whr/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Women's Health Research at Yale\",\"url\":\"https://medicine.yale.edu/whr/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Wu Tsai Institute\",\"url\":\"https://wti.yale.edu/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Center for Genomic Health\",\"url\":\"https://medicine.yale.edu/ycgh/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Combined Program in the Biological and Biomedical Sciences (BBS)\",\"url\":\"https://medicine.yale.edu/bbs/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Stem Cell Center\",\"url\":\"https://medicine.yale.edu/stemcell/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Ventures\",\"url\":\"https://ventures.yale.edu/\",\"@context\":\"http://schema.org\"}],\"alumniOf\":[{\"@type\":\"Organization\",\"name\":\"Yale University, School of Medicine, Psychiatry (1991)\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"FIDIA-Georgetown Institute for the Neurosciences (1987)\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"NIMH-Laboratory of Preclinical Pharmacology (1985)\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Padua University Medical University (1979)\",\"@context\":\"http://schema.org\"}],\"sameAs\":[],\"@context\":\"http://schema.org\"}],\"description\":\"Jang Y, Tomasini L, Bae T, Szekely A, Vaccarino F, Abyzov A. Transgenerational transmission of post-zygotic mutations suggests symmetric contribution of first two blastomeres to human germline. Nature Communications 2024, 15: 9117. <a href=\\\"https://pubmed.ncbi.nlm.nih.gov/39438473\\\" target=\\\"_blank\\\">PMID: 39438473</a>, <a href=\\\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11496613\\\" target=\\\"_blank\\\">PMCID: PMC11496613</a>, <a href=\\\"https://doi.org/10.1038/s41467-024-53485-x\\\" target=\\\"_blank\\\">DOI: 10.1038/s41467-024-53485-x</a>.\",\"@context\":\"http://schema.org\"}"},{"schemaName":"MedicalScholarlyArticle","jsonData":"{\"@type\":\"MedicalScholarlyArticle\",\"publicationType\":\"Journal Article\",\"inLanguage\":\"en-US\",\"headline\":\"Tourette syndrome\",\"author\":[{\"@type\":\"Person\",\"name\":\"Flora Vaccarino\",\"description\":\"Flora Vaccarino is the Harris Professor at the Child Study Center and Professor in the Department of Neuroscience at Yale University. 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They then performed an extensive comparison of the organoid’s transcriptome and noncoding elements with isogenic postmortem human fetal cortex and characterized gene regulatory mechanisms that shape the earliest cell fate decisions in human cortical development. Her lab has generated an extensive collection of patient-derived iPSC lines to study altered gene regulatory mechanisms in Autism Spectrum Disorders. Her interests include human somatic genomic variation as a tool to study lineage specification in human embryonic development. She was one of the fiunding members of the Brain Somatic Mosaicism Network (BSMN), a multi-site consortium that studied somatic mosaicism and its implication for neuropsychiatric diseases. Vaccarino is a Fellow of American Association for the Advancement of Science and a member of the PsychENCODE the Somatic Mosaicism across Human Tissues ( SMaHT) Consortia.\",\"url\":\"https://medicine.yale.edu/profile/flora-vaccarino/\",\"email\":\"flora.vaccarino@yale.edu\",\"telephone\":\"+12037374147\",\"image\":{\"@type\":\"ImageObject\",\"url\":\"https://ysm-res.cloudinary.com/image/upload/c_limit,f_auto,h_630,q_auto,w_1200/v1/yms/prod/35647f85-7587-4df1-8e91-c3a764ccd6cb\",\"description\":\"2024-09-30-Flora-Vaccarino-\",\"height\":1200,\"width\":630,\"@context\":\"http://schema.org\"},\"address\":[],\"workLocation\":[],\"honorificSuffix\":[\"MD\"],\"award\":[],\"jobTitle\":[\"Harris Professor in the Child Study Center\"],\"affiliation\":[{\"@type\":\"Organization\",\"name\":\"Center for Brain & Mind Health\",\"url\":\"https://medicine.yale.edu/brain-mind-health/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Child & Adolescent Psychiatry Training Program\",\"url\":\"https://medicine.yale.edu/childstudy/education-and-training/clinical-internships-residencies-and-fellowships/child-and-adolescent-psychiatry-fellowship/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Child Study Center\",\"url\":\"https://medicine.yale.edu/childstudy/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Embryonic Stem Cell Research Oversight\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Interdepartmental Neuroscience Program\",\"url\":\"https://medicine.yale.edu/inp/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Kavli Institute for Neuroscience\",\"url\":\"https://medicine.yale.edu/kavli/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Neuroscience\",\"url\":\"https://medicine.yale.edu/neuroscience/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Neuroscience Track\",\"url\":\"https://medicine.yale.edu/bbs/tracks/neuroscience/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Program in Neurodevelopment and Regeneration\",\"url\":\"https://medicine.yale.edu/neurodevelopment/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Tic Disorder & Obsessive Compulsive Disorder Program\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Vaccarino Lab\",\"url\":\"https://medicine.yale.edu/lab/vaccarino/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"WHRY Pilot Project Program Investigators\",\"url\":\"https://medicine.yale.edu/whr/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Women's Health Research at Yale\",\"url\":\"https://medicine.yale.edu/whr/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Wu Tsai Institute\",\"url\":\"https://wti.yale.edu/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Center for Genomic Health\",\"url\":\"https://medicine.yale.edu/ycgh/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Combined Program in the Biological and Biomedical Sciences (BBS)\",\"url\":\"https://medicine.yale.edu/bbs/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Stem Cell Center\",\"url\":\"https://medicine.yale.edu/stemcell/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Ventures\",\"url\":\"https://ventures.yale.edu/\",\"@context\":\"http://schema.org\"}],\"alumniOf\":[{\"@type\":\"Organization\",\"name\":\"Yale University, School of Medicine, Psychiatry (1991)\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"FIDIA-Georgetown Institute for the Neurosciences (1987)\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"NIMH-Laboratory of Preclinical Pharmacology (1985)\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Padua University Medical University (1979)\",\"@context\":\"http://schema.org\"}],\"sameAs\":[],\"@context\":\"http://schema.org\"}],\"description\":\"Abdallah SB, Fasching L, Brady M, Bloch MH, Lombroso P, Vaccarino FM, Fernandez TV. Tourette syndrome. In: Rosenberg RN, Pascual JM, editors. Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease, Seventh Edition San Diego, CA: Elsevier/Academic Press; 2024. Chapter 53; p.951-962. \",\"@context\":\"http://schema.org\"}"},{"schemaName":"MedicalScholarlyArticle","jsonData":"{\"@type\":\"MedicalScholarlyArticle\",\"publicationType\":\"Journal Article\",\"inLanguage\":\"en-US\",\"headline\":\"Elevated antibody binding to striatal cholinergic interneurons in patients with pediatric acute-onset neuropsy\",\"url\":\"https://pubmed.ncbi.nlm.nih.gov/39084540\",\"author\":[{\"@type\":\"Person\",\"name\":\"Flora Vaccarino\",\"description\":\"Flora Vaccarino is the Harris Professor at the Child Study Center and Professor in the Department of Neuroscience at Yale University. She received her MD from the University of Padova in Italy. She spent few years as Neuropharmacology Fellow at NIH, trained in clinical psychiatry at Yale, and then was a Research Fellow in developmental genetics at the Yale School of Medicine, where she raised through the ranks to Assistant, Associate and full Professor. Vaccarino leads a multidisciplinary research group working towards new directions for the study of mammalian brain development, particularly human, using stem cell biology and genomics as tools. She has been studying brain development in animal models for over 20 years, focusing on the role of growth factor receptor signaling in the regulation of stem cell behavior and cerebral cortex morphogenesis. Inspired by Sasai’s work, Vaccarino and her lab pioneered the generation of 3D brain organoids from induced pluripotent stem cells (iPSCs) in 2012, and showed that they recapitulate early fetal development of the human cerebral cortex. They then performed an extensive comparison of the organoid’s transcriptome and noncoding elements with isogenic postmortem human fetal cortex and characterized gene regulatory mechanisms that shape the earliest cell fate decisions in human cortical development. Her lab has generated an extensive collection of patient-derived iPSC lines to study altered gene regulatory mechanisms in Autism Spectrum Disorders. Her interests include human somatic genomic variation as a tool to study lineage specification in human embryonic development. She was one of the fiunding members of the Brain Somatic Mosaicism Network (BSMN), a multi-site consortium that studied somatic mosaicism and its implication for neuropsychiatric diseases. Vaccarino is a Fellow of American Association for the Advancement of Science and a member of the PsychENCODE the Somatic Mosaicism across Human Tissues ( SMaHT) Consortia.\",\"url\":\"https://medicine.yale.edu/profile/flora-vaccarino/\",\"email\":\"flora.vaccarino@yale.edu\",\"telephone\":\"+12037374147\",\"image\":{\"@type\":\"ImageObject\",\"url\":\"https://ysm-res.cloudinary.com/image/upload/c_limit,f_auto,h_630,q_auto,w_1200/v1/yms/prod/35647f85-7587-4df1-8e91-c3a764ccd6cb\",\"description\":\"2024-09-30-Flora-Vaccarino-\",\"height\":1200,\"width\":630,\"@context\":\"http://schema.org\"},\"address\":[],\"workLocation\":[],\"honorificSuffix\":[\"MD\"],\"award\":[],\"jobTitle\":[\"Harris Professor in the Child Study Center\"],\"affiliation\":[{\"@type\":\"Organization\",\"name\":\"Center for Brain & Mind Health\",\"url\":\"https://medicine.yale.edu/brain-mind-health/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Child & Adolescent Psychiatry Training Program\",\"url\":\"https://medicine.yale.edu/childstudy/education-and-training/clinical-internships-residencies-and-fellowships/child-and-adolescent-psychiatry-fellowship/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Child Study Center\",\"url\":\"https://medicine.yale.edu/childstudy/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Embryonic Stem Cell Research Oversight\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Interdepartmental Neuroscience Program\",\"url\":\"https://medicine.yale.edu/inp/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Kavli Institute for Neuroscience\",\"url\":\"https://medicine.yale.edu/kavli/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Neuroscience\",\"url\":\"https://medicine.yale.edu/neuroscience/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Neuroscience Track\",\"url\":\"https://medicine.yale.edu/bbs/tracks/neuroscience/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Program in Neurodevelopment and Regeneration\",\"url\":\"https://medicine.yale.edu/neurodevelopment/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Tic Disorder & Obsessive Compulsive Disorder Program\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Vaccarino Lab\",\"url\":\"https://medicine.yale.edu/lab/vaccarino/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"WHRY Pilot Project Program Investigators\",\"url\":\"https://medicine.yale.edu/whr/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Women's Health Research at Yale\",\"url\":\"https://medicine.yale.edu/whr/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Wu Tsai Institute\",\"url\":\"https://wti.yale.edu/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Center for Genomic Health\",\"url\":\"https://medicine.yale.edu/ycgh/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Combined Program in the Biological and Biomedical Sciences (BBS)\",\"url\":\"https://medicine.yale.edu/bbs/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Stem Cell Center\",\"url\":\"https://medicine.yale.edu/stemcell/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Ventures\",\"url\":\"https://ventures.yale.edu/\",\"@context\":\"http://schema.org\"}],\"alumniOf\":[{\"@type\":\"Organization\",\"name\":\"Yale University, School of Medicine, Psychiatry (1991)\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"FIDIA-Georgetown Institute for the Neurosciences (1987)\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"NIMH-Laboratory of Preclinical Pharmacology (1985)\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Padua University Medical University (1979)\",\"@context\":\"http://schema.org\"}],\"sameAs\":[],\"@context\":\"http://schema.org\"}],\"description\":\"Xu J, Frankovich J, Liu R, Thienemann M, Silverman M, Farhadian B, Willett T, Manko C, Columbo L, Leibold C, Vaccarino F, Che A, Pittenger C. Elevated antibody binding to striatal cholinergic interneurons in patients with pediatric acute-onset neuropsychiatric syndrome. Brain Behavior And Immunity 2024, 122: 241-255. <a href=\\\"https://pubmed.ncbi.nlm.nih.gov/39084540\\\" target=\\\"_blank\\\">PMID: 39084540</a>, <a href=\\\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11569416\\\" target=\\\"_blank\\\">PMCID: PMC11569416</a>, <a href=\\\"https://doi.org/10.1016/j.bbi.2024.07.044\\\" target=\\\"_blank\\\">DOI: 10.1016/j.bbi.2024.07.044</a>.\",\"@context\":\"http://schema.org\"}"},{"schemaName":"MedicalScholarlyArticle","jsonData":"{\"@type\":\"MedicalScholarlyArticle\",\"publicationType\":\"Journal Article\",\"inLanguage\":\"en-US\",\"headline\":\"Early Developmental Origins of Cortical Disorders Modeled in Human Neural Stem Cells.\",\"url\":\"https://pubmed.ncbi.nlm.nih.gov/38915580\",\"author\":[{\"@type\":\"Person\",\"name\":\"Flora Vaccarino\",\"description\":\"Flora Vaccarino is the Harris Professor at the Child Study Center and Professor in the Department of Neuroscience at Yale University. 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They then performed an extensive comparison of the organoid’s transcriptome and noncoding elements with isogenic postmortem human fetal cortex and characterized gene regulatory mechanisms that shape the earliest cell fate decisions in human cortical development. Her lab has generated an extensive collection of patient-derived iPSC lines to study altered gene regulatory mechanisms in Autism Spectrum Disorders. Her interests include human somatic genomic variation as a tool to study lineage specification in human embryonic development. She was one of the fiunding members of the Brain Somatic Mosaicism Network (BSMN), a multi-site consortium that studied somatic mosaicism and its implication for neuropsychiatric diseases. Vaccarino is a Fellow of American Association for the Advancement of Science and a member of the PsychENCODE the Somatic Mosaicism across Human Tissues ( SMaHT) Consortia.\",\"url\":\"https://medicine.yale.edu/profile/flora-vaccarino/\",\"email\":\"flora.vaccarino@yale.edu\",\"telephone\":\"+12037374147\",\"image\":{\"@type\":\"ImageObject\",\"url\":\"https://ysm-res.cloudinary.com/image/upload/c_limit,f_auto,h_630,q_auto,w_1200/v1/yms/prod/35647f85-7587-4df1-8e91-c3a764ccd6cb\",\"description\":\"2024-09-30-Flora-Vaccarino-\",\"height\":1200,\"width\":630,\"@context\":\"http://schema.org\"},\"address\":[],\"workLocation\":[],\"honorificSuffix\":[\"MD\"],\"award\":[],\"jobTitle\":[\"Harris Professor in the Child Study Center\"],\"affiliation\":[{\"@type\":\"Organization\",\"name\":\"Center for Brain & Mind Health\",\"url\":\"https://medicine.yale.edu/brain-mind-health/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Child & Adolescent Psychiatry Training Program\",\"url\":\"https://medicine.yale.edu/childstudy/education-and-training/clinical-internships-residencies-and-fellowships/child-and-adolescent-psychiatry-fellowship/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Child Study Center\",\"url\":\"https://medicine.yale.edu/childstudy/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Embryonic Stem Cell Research Oversight\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Interdepartmental Neuroscience Program\",\"url\":\"https://medicine.yale.edu/inp/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Kavli Institute for Neuroscience\",\"url\":\"https://medicine.yale.edu/kavli/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Neuroscience\",\"url\":\"https://medicine.yale.edu/neuroscience/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Neuroscience Track\",\"url\":\"https://medicine.yale.edu/bbs/tracks/neuroscience/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Program in Neurodevelopment and Regeneration\",\"url\":\"https://medicine.yale.edu/neurodevelopment/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Tic Disorder & Obsessive Compulsive Disorder Program\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Vaccarino Lab\",\"url\":\"https://medicine.yale.edu/lab/vaccarino/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"WHRY Pilot Project Program Investigators\",\"url\":\"https://medicine.yale.edu/whr/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Women's Health Research at Yale\",\"url\":\"https://medicine.yale.edu/whr/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Wu Tsai Institute\",\"url\":\"https://wti.yale.edu/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Center for Genomic Health\",\"url\":\"https://medicine.yale.edu/ycgh/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Combined Program in the Biological and Biomedical Sciences (BBS)\",\"url\":\"https://medicine.yale.edu/bbs/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Stem Cell Center\",\"url\":\"https://medicine.yale.edu/stemcell/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Ventures\",\"url\":\"https://ventures.yale.edu/\",\"@context\":\"http://schema.org\"}],\"alumniOf\":[{\"@type\":\"Organization\",\"name\":\"Yale University, School of Medicine, Psychiatry (1991)\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"FIDIA-Georgetown Institute for the Neurosciences (1987)\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"NIMH-Laboratory of Preclinical Pharmacology (1985)\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Padua University Medical University (1979)\",\"@context\":\"http://schema.org\"}],\"sameAs\":[],\"@context\":\"http://schema.org\"}],\"description\":\"Mato-Blanco X, Kim SK, Jourdon A, Ma S, Tebbenkamp ATN, Liu F, Duque A, Vaccarino FM, Sestan N, Colantuoni C, Rakic P, Santpere G, Micali N. Early Developmental Origins of Cortical Disorders Modeled in Human Neural Stem Cells. BioRxiv 2024 <a href=\\\"https://pubmed.ncbi.nlm.nih.gov/38915580\\\" target=\\\"_blank\\\">PMID: 38915580</a>, DOI: 10.1101/2024.06.14.598925.\",\"@context\":\"http://schema.org\"}"},{"schemaName":"MedicalScholarlyArticle","jsonData":"{\"@type\":\"MedicalScholarlyArticle\",\"publicationType\":\"Journal Article\",\"inLanguage\":\"en-US\",\"headline\":\"Massively parallel characterization of regulatory elements in the developing human cortex\",\"url\":\"https://pubmed.ncbi.nlm.nih.gov/38781390\",\"author\":[{\"@type\":\"Person\",\"name\":\"Flora Vaccarino\",\"description\":\"Flora Vaccarino is the Harris Professor at the Child Study Center and Professor in the Department of Neuroscience at Yale University. She received her MD from the University of Padova in Italy. 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They then performed an extensive comparison of the organoid’s transcriptome and noncoding elements with isogenic postmortem human fetal cortex and characterized gene regulatory mechanisms that shape the earliest cell fate decisions in human cortical development. Her lab has generated an extensive collection of patient-derived iPSC lines to study altered gene regulatory mechanisms in Autism Spectrum Disorders. Her interests include human somatic genomic variation as a tool to study lineage specification in human embryonic development. She was one of the fiunding members of the Brain Somatic Mosaicism Network (BSMN), a multi-site consortium that studied somatic mosaicism and its implication for neuropsychiatric diseases. 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Rajagopalan A, Reach S, Reimonn T, Ressler K, Ross D, Roussos P, Rozowsky J, Ruth M, Ruzicka W, Sanders S, Schneider J, Scuderi S, Sebra R, Sestan N, Seyfried N, Shao Z, Shedd N, Shieh A, Shin J, Skarica M, Snijders C, Song H, State M, Stein J, Steyert M, Subburaju S, Sudhof T, Snyder M, Tao R, Therrien K, Tsai L, Urban A, Vaccarino F, van Bakel H, Vo D, Voloudakis G, Wamsley B, Wang T, Wang S, Wang D, Wang Y, Warrell J, Wei Y, Weimer A, Weinberger D, Wen C, Weng Z, Whalen S, White K, Willsey A, Won H, Wong W, Wu H, Wu F, Wuchty S, Wylie D, Xu S, Yap C, Zeng B, Zhang P, Zhang C, Zhang B, Zhang J, Zhang Y, Zhou X, Ziffra R, Zeier Z, Zintel T. Massively parallel characterization of regulatory elements in the developing human cortex. Science 2024, 384: eadh0559. <a href=\\\"https://pubmed.ncbi.nlm.nih.gov/38781390\\\" target=\\\"_blank\\\">PMID: 38781390</a>, <a href=\\\"https://doi.org/10.1126/science.adh0559\\\" target=\\\"_blank\\\">DOI: 10.1126/science.adh0559</a>.\",\"@context\":\"http://schema.org\"}"},{"schemaName":"MedicalScholarlyArticle","jsonData":"{\"@type\":\"MedicalScholarlyArticle\",\"publicationType\":\"Journal Article\",\"inLanguage\":\"en-US\",\"headline\":\"Evaluating performance and applications of sample-wise cell deconvolution methods on human brain transcriptomi\",\"url\":\"https://pubmed.ncbi.nlm.nih.gov/38781336\",\"author\":[{\"@type\":\"Person\",\"name\":\"Flora Vaccarino\",\"description\":\"Flora Vaccarino is the Harris Professor at the Child Study Center and Professor in the Department of Neuroscience at Yale University. She received her MD from the University of Padova in Italy. She spent few years as Neuropharmacology Fellow at NIH, trained in clinical psychiatry at Yale, and then was a Research Fellow in developmental genetics at the Yale School of Medicine, where she raised through the ranks to Assistant, Associate and full Professor. Vaccarino leads a multidisciplinary research group working towards new directions for the study of mammalian brain development, particularly human, using stem cell biology and genomics as tools. She has been studying brain development in animal models for over 20 years, focusing on the role of growth factor receptor signaling in the regulation of stem cell behavior and cerebral cortex morphogenesis. Inspired by Sasai’s work, Vaccarino and her lab pioneered the generation of 3D brain organoids from induced pluripotent stem cells (iPSCs) in 2012, and showed that they recapitulate early fetal development of the human cerebral cortex. They then performed an extensive comparison of the organoid’s transcriptome and noncoding elements with isogenic postmortem human fetal cortex and characterized gene regulatory mechanisms that shape the earliest cell fate decisions in human cortical development. Her lab has generated an extensive collection of patient-derived iPSC lines to study altered gene regulatory mechanisms in Autism Spectrum Disorders. Her interests include human somatic genomic variation as a tool to study lineage specification in human embryonic development. She was one of the fiunding members of the Brain Somatic Mosaicism Network (BSMN), a multi-site consortium that studied somatic mosaicism and its implication for neuropsychiatric diseases. Vaccarino is a Fellow of American Association for the Advancement of Science and a member of the PsychENCODE the Somatic Mosaicism across Human Tissues ( SMaHT) Consortia.\",\"url\":\"https://medicine.yale.edu/profile/flora-vaccarino/\",\"email\":\"flora.vaccarino@yale.edu\",\"telephone\":\"+12037374147\",\"image\":{\"@type\":\"ImageObject\",\"url\":\"https://ysm-res.cloudinary.com/image/upload/c_limit,f_auto,h_630,q_auto,w_1200/v1/yms/prod/35647f85-7587-4df1-8e91-c3a764ccd6cb\",\"description\":\"2024-09-30-Flora-Vaccarino-\",\"height\":1200,\"width\":630,\"@context\":\"http://schema.org\"},\"address\":[],\"workLocation\":[],\"honorificSuffix\":[\"MD\"],\"award\":[],\"jobTitle\":[\"Harris Professor in the Child Study Center\"],\"affiliation\":[{\"@type\":\"Organization\",\"name\":\"Center for Brain & Mind Health\",\"url\":\"https://medicine.yale.edu/brain-mind-health/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Child & Adolescent Psychiatry Training Program\",\"url\":\"https://medicine.yale.edu/childstudy/education-and-training/clinical-internships-residencies-and-fellowships/child-and-adolescent-psychiatry-fellowship/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Child Study Center\",\"url\":\"https://medicine.yale.edu/childstudy/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Embryonic Stem Cell Research Oversight\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Interdepartmental Neuroscience Program\",\"url\":\"https://medicine.yale.edu/inp/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Kavli Institute for Neuroscience\",\"url\":\"https://medicine.yale.edu/kavli/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Neuroscience\",\"url\":\"https://medicine.yale.edu/neuroscience/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Neuroscience Track\",\"url\":\"https://medicine.yale.edu/bbs/tracks/neuroscience/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Program in Neurodevelopment and Regeneration\",\"url\":\"https://medicine.yale.edu/neurodevelopment/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Tic Disorder & Obsessive Compulsive Disorder Program\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Vaccarino Lab\",\"url\":\"https://medicine.yale.edu/lab/vaccarino/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"WHRY Pilot Project Program Investigators\",\"url\":\"https://medicine.yale.edu/whr/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Women's Health Research at Yale\",\"url\":\"https://medicine.yale.edu/whr/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Wu Tsai Institute\",\"url\":\"https://wti.yale.edu/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Center for Genomic Health\",\"url\":\"https://medicine.yale.edu/ycgh/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Combined Program in the Biological and Biomedical Sciences (BBS)\",\"url\":\"https://medicine.yale.edu/bbs/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Stem Cell Center\",\"url\":\"https://medicine.yale.edu/stemcell/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Ventures\",\"url\":\"https://ventures.yale.edu/\",\"@context\":\"http://schema.org\"}],\"alumniOf\":[{\"@type\":\"Organization\",\"name\":\"Yale University, School of Medicine, Psychiatry (1991)\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"FIDIA-Georgetown Institute for the Neurosciences (1987)\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"NIMH-Laboratory of Preclinical Pharmacology (1985)\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Padua University Medical University (1979)\",\"@context\":\"http://schema.org\"}],\"sameAs\":[],\"@context\":\"http://schema.org\"}],\"description\":\"Dai R, Chu T, Zhang M, Wang X, Jourdon A, Wu F, Mariani J, Vaccarino F, Lee D, Fullard J, Hoffman G, Roussos P, Wang Y, Wang X, Pinto D, Wang S, Zhang C, consortium P, Chen C, Liu C. Evaluating performance and applications of sample-wise cell deconvolution methods on human brain transcriptomic data. Science Advances 2024, 10: eadh2588. <a href=\\\"https://pubmed.ncbi.nlm.nih.gov/38781336\\\" target=\\\"_blank\\\">PMID: 38781336</a>, <a href=\\\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11114236\\\" target=\\\"_blank\\\">PMCID: PMC11114236</a>, <a href=\\\"https://doi.org/10.1126/sciadv.adh2588\\\" target=\\\"_blank\\\">DOI: 10.1126/sciadv.adh2588</a>.\",\"@context\":\"http://schema.org\"}"},{"schemaName":"MedicalScholarlyArticle","jsonData":"{\"@type\":\"MedicalScholarlyArticle\",\"publicationType\":\"Journal Article\",\"inLanguage\":\"en-US\",\"headline\":\"Specification of human regional brain lineages using orthogonal gradients of WNT and SHH in organoids.\",\"url\":\"https://pubmed.ncbi.nlm.nih.gov/38798404\",\"author\":[{\"@type\":\"Person\",\"name\":\"Flora Vaccarino\",\"description\":\"Flora Vaccarino is the Harris Professor at the Child Study Center and Professor in the Department of Neuroscience at Yale University. She received her MD from the University of Padova in Italy. She spent few years as Neuropharmacology Fellow at NIH, trained in clinical psychiatry at Yale, and then was a Research Fellow in developmental genetics at the Yale School of Medicine, where she raised through the ranks to Assistant, Associate and full Professor. Vaccarino leads a multidisciplinary research group working towards new directions for the study of mammalian brain development, particularly human, using stem cell biology and genomics as tools. She has been studying brain development in animal models for over 20 years, focusing on the role of growth factor receptor signaling in the regulation of stem cell behavior and cerebral cortex morphogenesis. Inspired by Sasai’s work, Vaccarino and her lab pioneered the generation of 3D brain organoids from induced pluripotent stem cells (iPSCs) in 2012, and showed that they recapitulate early fetal development of the human cerebral cortex. They then performed an extensive comparison of the organoid’s transcriptome and noncoding elements with isogenic postmortem human fetal cortex and characterized gene regulatory mechanisms that shape the earliest cell fate decisions in human cortical development. Her lab has generated an extensive collection of patient-derived iPSC lines to study altered gene regulatory mechanisms in Autism Spectrum Disorders. Her interests include human somatic genomic variation as a tool to study lineage specification in human embryonic development. She was one of the fiunding members of the Brain Somatic Mosaicism Network (BSMN), a multi-site consortium that studied somatic mosaicism and its implication for neuropsychiatric diseases. Vaccarino is a Fellow of American Association for the Advancement of Science and a member of the PsychENCODE the Somatic Mosaicism across Human Tissues ( SMaHT) Consortia.\",\"url\":\"https://medicine.yale.edu/profile/flora-vaccarino/\",\"email\":\"flora.vaccarino@yale.edu\",\"telephone\":\"+12037374147\",\"image\":{\"@type\":\"ImageObject\",\"url\":\"https://ysm-res.cloudinary.com/image/upload/c_limit,f_auto,h_630,q_auto,w_1200/v1/yms/prod/35647f85-7587-4df1-8e91-c3a764ccd6cb\",\"description\":\"2024-09-30-Flora-Vaccarino-\",\"height\":1200,\"width\":630,\"@context\":\"http://schema.org\"},\"address\":[],\"workLocation\":[],\"honorificSuffix\":[\"MD\"],\"award\":[],\"jobTitle\":[\"Harris Professor in the Child Study Center\"],\"affiliation\":[{\"@type\":\"Organization\",\"name\":\"Center for Brain & Mind Health\",\"url\":\"https://medicine.yale.edu/brain-mind-health/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Child & Adolescent Psychiatry Training Program\",\"url\":\"https://medicine.yale.edu/childstudy/education-and-training/clinical-internships-residencies-and-fellowships/child-and-adolescent-psychiatry-fellowship/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Child Study Center\",\"url\":\"https://medicine.yale.edu/childstudy/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Embryonic Stem Cell Research Oversight\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Interdepartmental Neuroscience Program\",\"url\":\"https://medicine.yale.edu/inp/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Kavli Institute for Neuroscience\",\"url\":\"https://medicine.yale.edu/kavli/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Neuroscience\",\"url\":\"https://medicine.yale.edu/neuroscience/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Neuroscience Track\",\"url\":\"https://medicine.yale.edu/bbs/tracks/neuroscience/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Program in Neurodevelopment and Regeneration\",\"url\":\"https://medicine.yale.edu/neurodevelopment/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Tic Disorder & Obsessive Compulsive Disorder Program\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Vaccarino Lab\",\"url\":\"https://medicine.yale.edu/lab/vaccarino/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"WHRY Pilot Project Program Investigators\",\"url\":\"https://medicine.yale.edu/whr/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Women's Health Research at Yale\",\"url\":\"https://medicine.yale.edu/whr/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Wu Tsai Institute\",\"url\":\"https://wti.yale.edu/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Center for Genomic Health\",\"url\":\"https://medicine.yale.edu/ycgh/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Combined Program in the Biological and Biomedical Sciences (BBS)\",\"url\":\"https://medicine.yale.edu/bbs/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Stem Cell Center\",\"url\":\"https://medicine.yale.edu/stemcell/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Ventures\",\"url\":\"https://ventures.yale.edu/\",\"@context\":\"http://schema.org\"}],\"alumniOf\":[{\"@type\":\"Organization\",\"name\":\"Yale University, School of Medicine, Psychiatry (1991)\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"FIDIA-Georgetown Institute for the Neurosciences (1987)\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"NIMH-Laboratory of Preclinical Pharmacology (1985)\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Padua University Medical University (1979)\",\"@context\":\"http://schema.org\"}],\"sameAs\":[],\"@context\":\"http://schema.org\"}],\"description\":\"Scuderi S, Kang TY, Jourdon A, Yang L, Wu F, Nelson A, Anderson GM, Mariani J, Sarangi V, Abyzov A, Levchenko A, Vaccarino FM. Specification of human regional brain lineages using orthogonal gradients of WNT and SHH in organoids. BioRxiv 2024 <a href=\\\"https://pubmed.ncbi.nlm.nih.gov/38798404\\\" target=\\\"_blank\\\">PMID: 38798404</a>, DOI: 10.1101/2024.05.18.594828.\",\"@context\":\"http://schema.org\"}"}]}}],"sidebarComponents":[],"contextNavigation":null}</script> <script>window['applicationSettings'] = {"shouldShowSuppressedImageWarnings":false,"shouldShowBugReportButton":false,"shouldShowDownloadAsWordButton":false,"captchaKey":"a46dfca5-98da-4ec7-83e2-16980be648d0","facebookShareUrl":"https://www.facebook.com/dialog/share?app_id=604142276782606&display=popup&href=","isSearchFeedbackEnabled":true,"isSearchAnalyticsEnabled":true,"siteimproveScriptUrl":"https://siteimproveanalytics.com/js/siteanalyze_373.js","radarKey":"prj_live_pk_e9bc38cc9ac871b02332c0d599d7a893c03ad94d","mediaStatistics":{"baseUrl":"https://media-statistics-prod.ysmdevs.com","apiKey":"249c64e3-d0cc-45ed-97a0-5d3106411485","isEnabled":true}};</script> <noscript id="modern__LOADABLE_REQUIRED_CHUNKS__">[4589,7640,6443,4480,6736,6293,3688,9819,6391,1739,8404,2944,3053]</noscript><noscript id="modern__LOADABLE_REQUIRED_CHUNKS___ext">{"namedChunks":["modules-page-components-ComponentWrapper","modules-profile-components-profile-details-ProfileDetails","modules-footer-components-Footer"]}</noscript> <script async data-chunk="main" src="https://cdn1.medicine.yale.edu/build/main.es2015.ff4738d7fae8cd594b64.js" type="module" crossorigin="anonymous"></script> <script async data-chunk="modules-profile-components-profile-details-ProfileDetails" src="https://cdn1.medicine.yale.edu/build/4589.es2015.4c47bf8350b6c4f009a0.js" type="module" crossorigin="anonymous"></script> <script async data-chunk="modules-profile-components-profile-details-ProfileDetails" src="https://cdn1.medicine.yale.edu/build/7640.es2015.305f7f9c55b908f8d7a2.js" type="module" crossorigin="anonymous"></script> <script async data-chunk="modules-profile-components-profile-details-ProfileDetails" src="https://cdn1.medicine.yale.edu/build/6443.es2015.4890cbc400a8796edee4.js" type="module" crossorigin="anonymous"></script> <script async data-chunk="modules-profile-components-profile-details-ProfileDetails" src="https://cdn1.medicine.yale.edu/build/4480.es2015.473ffd08eabb889a822c.js" type="module" crossorigin="anonymous"></script> <script async data-chunk="modules-profile-components-profile-details-ProfileDetails" src="https://cdn1.medicine.yale.edu/build/6736.es2015.36fcc1e83004e7c6188d.js" type="module" crossorigin="anonymous"></script> <script async data-chunk="modules-profile-components-profile-details-ProfileDetails" src="https://cdn1.medicine.yale.edu/build/6293.es2015.a955a43c28f0a24dd4fa.js" type="module" crossorigin="anonymous"></script> <script async data-chunk="modules-profile-components-profile-details-ProfileDetails" src="https://cdn1.medicine.yale.edu/build/3688.es2015.61379309f5274f4b1158.js" type="module" crossorigin="anonymous"></script> <script async data-chunk="modules-profile-components-profile-details-ProfileDetails" src="https://cdn1.medicine.yale.edu/build/9819.es2015.0646cda325bf5675c53b.js" type="module" crossorigin="anonymous"></script> <script async data-chunk="modules-profile-components-profile-details-ProfileDetails" src="https://cdn1.medicine.yale.edu/build/6391.es2015.97db24b9904b8087c7f2.js" type="module" crossorigin="anonymous"></script> <script async data-chunk="modules-profile-components-profile-details-ProfileDetails" src="https://cdn1.medicine.yale.edu/build/1739.es2015.57164941c596da5ad19e.js" type="module" crossorigin="anonymous"></script> <script async data-chunk="modules-profile-components-profile-details-ProfileDetails" src="https://cdn1.medicine.yale.edu/build/8404.es2015.107e30362b95296552a9.js" type="module" crossorigin="anonymous"></script> <script async data-chunk="modules-profile-components-profile-details-ProfileDetails" src="https://cdn1.medicine.yale.edu/build/2944.es2015.369c6ed4c76b88a67657.js" type="module" crossorigin="anonymous"></script> <script async data-chunk="modules-footer-components-Footer" src="https://cdn1.medicine.yale.edu/build/3053.es2015.359573b73638d4069b34.js" type="module" crossorigin="anonymous"></script> <link rel="stylesheet" href="https://use.typekit.net/eqf4dwf.css" as="style" crossorigin>  <script async type="text/plain" data-cookiecategory="analytics" src="https://siteimproveanalytics.com/js/siteanalyze_373.js"></script> </body> </html>

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Flora Vaccarino, MD < Child Study Center