Chan Zuckerberg Biohub Chicago

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href="https://www.facebook.com/czbiohub/" target="_blank" aria-label="Link to CZ Biohub Facebook"> <img alt="Facebook Icon" src="https://www.czbiohub.org/chi/wp-content/themes/czbiohub/img/socials/facebook.svg" /> </a> <a href="https://twitter.com/czbiohub" target="_blank" aria-label="Link to CZ Biohub Twitter"> <img alt="Twitter Icon" src="https://www.czbiohub.org/chi/wp-content/themes/czbiohub/img/socials/new/social-x.svg" /> </a> <a href="https://www.linkedin.com/company/cz-biohub/" aria-label="Link to CZ Biohub Linkedin" target="_blank"> <img alt="LinkedIn Icon" src="https://www.czbiohub.org/chi/wp-content/themes/czbiohub/img/socials/linkedin.svg" /> </a> <a href="https://www.youtube.com/c/ChanZuckerbergBiohub/" aria-label="Link to CZ Biohub YouTube" target="_blank"> <img alt="YouTube Icon" src="https://www.czbiohub.org/chi/wp-content/themes/czbiohub/img/socials/youtube.svg" /> </a> <a href="https://www.instagram.com/chanzuckerbergbiohub/" aria-label="Link to CZ Biohub Instagram" target="_blank"> <img alt="instagram Icon" src="https://www.czbiohub.org/chi/wp-content/themes/czbiohub/img/socials/instagram.svg" /> </a> </div> </div> </div> </header> <div class="nav-bg"></div> <main> <div class="max-container content-wrapper">  <section class="locationsHome__hero relative flex a-end"> <img class="locationsHome__heroBg locationsHome__heroBg-desk img-fit-cover" src="https://www.czbiohub.org/chi/wp-content/uploads/sites/19/2024/01/chicago-hero.jpeg" alt="Chicago skyline" > <img class="locationsHome__heroBg locationsHome__heroBg-mobile img-fit-cover" src="https://www.czbiohub.org/chi/wp-content/uploads/sites/19/2024/01/chicago-hero.jpeg" alt="Chicago skyline" > <div class="container-1060 relative"> <div class="text-wrap" style="max-width: 70rem"> <h1 class="h0 FontColor--white">Chan Zuckerberg Biohub Chicago</h1> </div> </div> </section>  <section class="locationsHome__intro relative"> <div class="container-1060 relative"> <figure class="locationsHome__intro-logo"> <img src="https://www.czbiohub.org/chi/wp-content/uploads/sites/19/2024/09/chi-university-cluster.png" alt="circle pointing to Northwestern University, University of Chicago, and University of Illinois logos" > </figure> <div class="text-wrap"> <p>CZ Biohub Chicago is engineering technologies to make precise, molecular-level measurements of biological processes within human tissues, with an ultimate goal of understanding and treating the inflammatory states that underlie many diseases.</p> <p>CZ Biohub Chicago is part of the CZ Biohub Network, a group of nonprofit research institutes created and supported by the <span class="nowrap"><a href="https://chanzuckerberg.com/" target="_blank" rel="noopener">Chan Zuckerberg Initiative</a>.</span> The institute was created as a close collaboration between University of Chicago, University of Illinois Urbana-Champaign, and Northwestern University.</p> </div> </div> </section>  <section> <div class="container-1060 relative"> <div class="locationsHome__sec-title"> <h2 class="eye--xl text-uppercase"> OUR FOCUS </h2> </div> <div class="ZSection"> <article class="ZSection__row flex wrap j-sb"> <div class="ZSection__float float-left"> <div class="w-full"> <figure class="ZSection__float-image relative"> <img src="https://www.czbiohub.org/chi/wp-content/uploads/sites/19/2023/02/cz-biohub-chicago-zebrafish-heart-2.jpg" alt="Zebrafish heart" > <figcaption class="new-caption"> Coronary vessels of an adult zebrafish heart shown in green. Photo provided by Jingli Cao. </figcaption> </figure> <h2 class="h4">Creating New Technologies to Understand Inflammation and the Immune System</h2> <p>CZ Biohub Chicago is using a unique, engineering-driven approach to study human biology. By embedding thousands of sensors and sampling probes in tissues, scientists will be able to monitor molecular and cellular signals with unprecedented resolution, and reveal how disruptions in these processes lead to inflammation and disease. Using cutting-edge omics and artificial intelligence to augment tissue-based systems, the CZ Biohub Chicago will uncover new insights into how inflammation begins and how it can be controlled.</p> <p>Inflammation and overactive immune cells play a key role in many diseases, including cancer, heart disease, and Alzheimer’s disease, and are also implicated in organ failure, and severe infectious diseases like COVID-19. But inducing inflammation in a controlled way can also be used to combat disease: in cancer immunotherapy, the immune system is unleashed and directed toward tumors. The CZ Biohub Chicago’s first explorations of inflammatory processes will involve human skin tissue, as many skin diseases are driven by inflammation.</p> <p>Through advances in genomics, molecular biology, and most recently, single-cell biology, scientists have made great strides in understanding the structure and function of individual cells. But our organs are made up of specialized tissues that contain billions of cells — our heart muscle alone is estimated to comprise more than two billion cells — so gaining insights about how tissues work as a whole, in both health and disease, is an enormous challenge.</p> <p>To begin to crack this problem, the engineered platforms that are under development at the CZ Biohub Chicago are combining state-of-the-art technologies to make the first holistic and direct measurements of inflammation in human tissue. These tools will allow researchers to monitor the activity of immune cells within tissues in real time, with the goal of finding ways to steer the immune system away from the “tipping points” that lead to inflammatory disorders. With a more comprehensive understanding of this biology, new approaches to treating a range of diseases will be made possible, with the ultimate aim of making inflammation-driven diseases more treatable and preventable.</p> <a class="ZSection__cta eye--m text-uppercase" href="https://www.czbiohub.org/news/new-chan-zuckerberg-biohub-chicago-will-engineer-technologies-to-measure-human-biology/" target="_blank" > <svg width="13" height="13" fill="none" xmlns="http://www.w3.org/2000/svg"> <path fill-rule="evenodd" clip-rule="evenodd" d="M6.60282 12.3045C9.75192 12.3045 12.3048 9.75168 12.3048 6.60258C12.3048 3.45348 9.75192 0.900635 6.60282 0.900635C3.45373 0.900635 0.900879 3.45348 0.900879 6.60258C0.900879 9.75168 3.45373 12.3045 6.60282 12.3045Z" stroke="#00A3E0" stroke-linecap="round" stroke-linejoin="round" /> <path d="M6.60303 3.75159V9.45353" stroke="#00A3E0" stroke-linecap="round" stroke-linejoin="round" /> <path d="M9.4539 6.60254H3.75195" stroke="#00A3E0" stroke-linecap="round" stroke-linejoin="round" /> </svg> Learn more </a> </div> </div> </article> </div> </div> </section>     <section class="locationsHome__leadership"> <div class="container-1060 relative"> <div class="locationsHome__sec-title"> <h2 class="eye--xl text-uppercase"> LEADERSHIP </h2> </div> <div class="locationsHome__leadership-wrap"> <a class="locationsHome__leadership-item text-center" href="https://www.czbiohub.org/chi/people/leadership/shana-kelley-phd/"> <figure class="relative"> <img class="img-fit-cover" src="https://www.czbiohub.org/chi/wp-content/uploads/sites/19/2023/02/Shana-o-kelly.jpg?w=360" alt="Shana O. Kelley, Ph.D." > </figure> <h3 class="eye--m text-uppercase">Shana O. Kelley, Ph.D.</h3> <p class="p--xs FontColor--gray-300">President</p> </a> <a class="locationsHome__leadership-item text-center" href="https://www.czbiohub.org/chi/people/leadership/amanda-murphy-mba/"> <figure class="relative"> <img class="img-fit-cover" src="https://www.czbiohub.org/chi/wp-content/uploads/sites/19/2024/10/amanda-murphy.webp?w=760" alt="Amanda Murphy, MBA" > </figure> <h3 class="eye--m text-uppercase">Amanda Murphy, MBA</h3> <p class="p--xs FontColor--gray-300">Chief Operating Officer</p> </a> <a class="locationsHome__leadership-item text-center" href="https://www.czbiohub.org/chi/people/leadership/aly-azeem-khan-phd/"> <figure class="relative"> <img class="img-fit-cover" src="https://www.czbiohub.org/chi/wp-content/uploads/sites/19/2024/10/aly-khan.webp?w=760" alt="Aly Azeem Khan, Ph.D." > </figure> <h3 class="eye--m text-uppercase">Aly Azeem Khan, Ph.D.</h3> <p class="p--xs FontColor--gray-300">Head of Artificial Intelligence/Machine Learning</p> </a> </div> <a class="locationsHome__leadership-cta eye--m text-uppercase" href="/chi/people/#leadership" target="" > <svg viewBox="0 0 13 13" fill="none" xmlns="http://www.w3.org/2000/svg"> <path fill-rule="evenodd" clip-rule="evenodd" d="M6.60282 12.3045C9.75192 12.3045 12.3048 9.75168 12.3048 6.60258C12.3048 3.45348 9.75192 0.900635 6.60282 0.900635C3.45373 0.900635 0.900879 3.45348 0.900879 6.60258C0.900879 9.75168 3.45373 12.3045 6.60282 12.3045Z" stroke="#00A3E0" stroke-linecap="round" stroke-linejoin="round"></path> <path d="M6.60303 3.75159V9.45353" stroke="#00A3E0" stroke-linecap="round" stroke-linejoin="round"></path> <path d="M9.4539 6.60254H3.75195" stroke="#00A3E0" stroke-linecap="round" stroke-linejoin="round"></path> </svg> VIEW OUR COMPLETE LEADERSHIP TEAM </a> </div> </section>   <section class="locationsHome--blog"> <div class="container-1060 relative"> <section class="hub-logo"> <div class="hub-logo__container"> <a href="https://www.czbiohub.org/chi" aria-label="Life and Science 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248.594 65.575Z" fill="#565F63" /> <path d="M261.959 67.075L264.104 71.485H261.794L259.934 67.42H258.254V71.485H256.154V61.135H259.859C261.089 61.135 262.039 61.41 262.709 61.96C263.389 62.5 263.729 63.28 263.729 64.3C263.729 65.66 263.139 66.585 261.959 67.075ZM258.254 62.92V65.65H259.664C260.354 65.65 260.854 65.55 261.164 65.35C261.474 65.15 261.629 64.8 261.629 64.3C261.629 63.8 261.469 63.445 261.149 63.235C260.839 63.025 260.344 62.92 259.664 62.92H258.254Z" fill="#565F63" /> <path d="M270.107 65.32L273.887 71.485H271.382L268.742 67.12L267.512 68.74V71.485H265.412V61.135H267.512V65.605L270.782 61.135H273.272L270.107 65.32Z" fill="#565F63" /> </svg> </a> </div> </section> <section class="news-grid"> <a href="https://www.czbiohub.org/life-science/insights-from-inaugural-scientific-conference/" > <div class="news-card"> <div class="news-card__img "> <div class="cata-top cat-top"> <span class="category">Bioengineering</span> </div> <img class="" src="https://www.czbiohub.org/wp-content/uploads/2024/10/20240930-cbec-chicago-event.jpg?w=825" alt="Mikhail Shapiro presents during the Advanced Sensing lightning talks."> </div> <div class="news-card__content"> <h5 class="p--strong">The future is now: four insights from CZ Biohub Chicago’s inaugural scientific conference</h5> <p>Researchers gathered to discuss trends and technologies that will enable biological ...</p> <div class="news-card__cta eye--s text-uppercase"> <svg viewBox="0 0 13 13" fill="none" xmlns="http://www.w3.org/2000/svg"> <path fill-rule="evenodd" clip-rule="evenodd" d="M6.60282 12.3045C9.75192 12.3045 12.3048 9.75168 12.3048 6.60258C12.3048 3.45348 9.75192 0.900635 6.60282 0.900635C3.45373 0.900635 0.900879 3.45348 0.900879 6.60258C0.900879 9.75168 3.45373 12.3045 6.60282 12.3045Z" stroke="#00A3E0" stroke-linecap="round" stroke-linejoin="round"></path> <path d="M6.60303 3.75159V9.45353" stroke="#00A3E0" stroke-linecap="round" stroke-linejoin="round"></path> <path d="M9.4539 6.60254H3.75195" stroke="#00A3E0" stroke-linecap="round" stroke-linejoin="round"></path> </svg> Read More </div> </div> </div> </a> <a href="https://www.czbiohub.org/life-science/piecing-together-new-technologies-for-biomedicine/" > <div class="news-card"> <div class="news-card__img "> <div class="cata-top cat-top"> <span class="category">Bioengineering</span><span class="category">Our People</span> </div> <img class="" src="https://www.czbiohub.org/wp-content/uploads/2024/04/231004_ChicagoBiohub_chi_dr-18-1-e1731710139150.jpg?w=960" alt="Zongjie (Daniel) Wang in the lab at CZ Biohub Chicago"> </div> <div class="news-card__content"> <h5 class="p--strong">Piecing together new technologies for biomedicine</h5> <p>A conversation with new CZ Biohub Chicago group leader, Daniel Wang ...</p> <div class="news-card__cta eye--s text-uppercase"> <svg viewBox="0 0 13 13" fill="none" xmlns="http://www.w3.org/2000/svg"> <path fill-rule="evenodd" clip-rule="evenodd" d="M6.60282 12.3045C9.75192 12.3045 12.3048 9.75168 12.3048 6.60258C12.3048 3.45348 9.75192 0.900635 6.60282 0.900635C3.45373 0.900635 0.900879 3.45348 0.900879 6.60258C0.900879 9.75168 3.45373 12.3045 6.60282 12.3045Z" stroke="#00A3E0" stroke-linecap="round" stroke-linejoin="round"></path> <path d="M6.60303 3.75159V9.45353" stroke="#00A3E0" stroke-linecap="round" stroke-linejoin="round"></path> <path d="M9.4539 6.60254H3.75195" stroke="#00A3E0" stroke-linecap="round" stroke-linejoin="round"></path> </svg> Read More </div> </div> </div> </a> <a href="https://www.czbiohub.org/life-science/high-risk-high-reward-shana-kelley-on-building-a-new-biohub/" > <div class="news-card"> <div class="news-card__img "> <div class="cata-top cat-top"> <span class="category">Our People</span><span class="category">Bioengineering</span> </div> <img class="" src="https://www.czbiohub.org/wp-content/uploads/2023/05/Shana_Kelley_preferred_dr-72_1000px.jpg?w=960" alt=""> </div> <div class="news-card__content"> <h5 class="p--strong">High Risk, High Reward: Shana Kelley on Building a New Biohub</h5> <p>President of new CZ Biohub Chicago brings experience in startups, nanotech, chemistry, and ...</p> <div class="news-card__cta eye--s text-uppercase"> <svg viewBox="0 0 13 13" fill="none" xmlns="http://www.w3.org/2000/svg"> <path fill-rule="evenodd" clip-rule="evenodd" d="M6.60282 12.3045C9.75192 12.3045 12.3048 9.75168 12.3048 6.60258C12.3048 3.45348 9.75192 0.900635 6.60282 0.900635C3.45373 0.900635 0.900879 3.45348 0.900879 6.60258C0.900879 9.75168 3.45373 12.3045 6.60282 12.3045Z" stroke="#00A3E0" stroke-linecap="round" stroke-linejoin="round"></path> <path d="M6.60303 3.75159V9.45353" stroke="#00A3E0" stroke-linecap="round" stroke-linejoin="round"></path> <path d="M9.4539 6.60254H3.75195" stroke="#00A3E0" stroke-linecap="round" stroke-linejoin="round"></path> </svg> Read More </div> </div> </div> </a> </section> </div> </section>  <section class="locationsHome__research"> <div class="container"> <div class="locationsHome__research-content"> <h2 class="h4">Our Research</h2> <p>CZ Biohub Chicago produces scientific research to advance our mission to support the science and technology that will make it possible to cure, prevent or manage all diseases by the end of the century. 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