CINXE.COM

<!DOCTYPE html> <html lang="en" class="no-js"> <head> <meta charset="UTF-8"> <meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes"> <title>Search</title> <meta id="meta-title" property="citation_title" content="Search"/> <meta id="og-title" property="og:title" content="Search"/> <meta name="twitter:widgets:autoload" content="off"/> <meta name="twitter:dnt" content="on"/> <meta name="twitter:widgets:csp" content="on"/> <meta name="google-site-verification" content="lQbRRf0vgPqMbnbCsgELjAjIIyJjiIWo917M7hBshvI"/> <meta id="og-image" property="og:image" content="https://escholarship.org/images/escholarship-facebook2.jpg"/> <meta id="og-image-width" property="og:image:width" content="1242"/> <meta id="og-image-height" property="og:image:height" content="1242"/> <link rel="stylesheet" href="/css/main-fa87d2fbdbef47d2.css"> <link rel="resource" type="application/l10n" href="/node_modules/pdfjs-embed2/dist/locale/locale.properties"> <noscript><style> .jsonly { display: none } </style></noscript>   <script type="text/plain" data-type="application/javascript" data-name="matomo"> var _paq = window._paq = window._paq || []; /* tracker methods like "setCustomDimension" should be called before "trackPageView" */ _paq.push(['trackPageView']); _paq.push(['enableLinkTracking']); (function() { var u="//matomo.cdlib.org/"; _paq.push(['setTrackerUrl', u+'matomo.php']); _paq.push(['setSiteId', '7']); var d=document, g=d.createElement('script'), s=d.getElementsByTagName('script')[0]; g.async=true; g.src=u+'matomo.js'; s.parentNode.insertBefore(g,s); console.log('*** MATOMO LOADED ***'); })(); </script>  </head> <body> <div id="main"><div data-reactroot=""><div class="body"><a href="#maincontent" class="c-skipnav">Skip to main content</a><div class="l_search"><div><div style="margin-top:-10px"></div><header id="#top" class="c-header"><a class="c-header__logo2" href="/"><picture><source srcSet="/images/logo_eschol-small.svg" media="(min-width: 870px)"/><img src="/images/logo_eschol-mobile.svg" alt="eScholarship"/></picture><div class="c-header__logo2-tagline">Open Access Publications from the University of California</div></a><div class="c-header__search"><form class="c-search1"><label class="c-search1__label" for="c-search1__field">search</label><input type="search" id="c-search1__field" name="q" class="c-search1__field" placeholder="Search over 500,000 items" autoCapitalize="off" value="author:Budde, Monika"/><button type="submit" class="c-search1__submit-button" aria-label="submit search"></button><button type="button" class="c-search1__search-close-button" aria-label="close search field"></button></form></div><button class="c-header__search-open-button" aria-label="open search field"></button></header></div><div class="c-navbar"><nav class="c-nav"><details open="" class="c-nav__main"><summary class="c-nav__main-button">Menu</summary><ul class="c-nav__main-items"><li><details class="c-nav__sub"><summary class="c-nav__sub-button">About eScholarship</summary><div class="c-nav__sub-items"><button class="c-nav__sub-items-button" aria-label="return to menu">Main Menu</button><ul><li><a href="/aboutEschol">About eScholarship</a></li><li><a href="/repository">eScholarship Repository</a></li><li><a href="/publishing">eScholarship Publishing</a></li><li><a href="/policies">Site policies</a></li><li><a href="/terms">Terms of Use and Copyright Information</a></li><li><a href="/privacyPolicy">Privacy statement</a></li></ul></div></details></li><li><details class="c-nav__sub"><summary class="c-nav__sub-button">Campus Sites</summary><div class="c-nav__sub-items"><button class="c-nav__sub-items-button" aria-label="return to menu">Main Menu</button><ul><li><a href="/uc/ucb">UC Berkeley</a></li><li><a href="/uc/ucd">UC Davis</a></li><li><a href="/uc/uci">UC Irvine</a></li><li><a href="/uc/ucla">UCLA</a></li><li><a href="/uc/ucm">UC Merced</a></li><li><a href="/uc/ucr">UC Riverside</a></li><li><a href="/uc/ucsd">UC San Diego</a></li><li><a href="/uc/ucsf">UCSF</a></li><li><a href="/uc/ucsb">UC Santa Barbara</a></li><li><a href="/uc/ucsc">UC Santa Cruz</a></li><li><a href="/uc/ucop">UC Office of the President</a></li><li><a href="/uc/lbnl">Lawrence Berkeley National Laboratory</a></li><li><a href="/uc/anrcs">UC Agriculture & Natural Resources</a></li></ul></div></details></li><li><a href="/ucoapolicies">UC Open Access Policies</a></li><li><a href="/publishing">eScholarship Publishing</a></li><li><a href="/ucpubs">UCPUBS</a></li></ul></details></nav></div><form id="facetForm" class="c-columns"><aside><div><div class="c-filter"><h1 class="c-filter__heading">Your search: "author:Budde, Monika"</h1><input type="hidden" name="q" value="author:Budde, Monika"/><div class="c-filter__results">11 results</div><div class="c-filter__inactive-note">No filters applied</div><details class="c-filter__active" open=""><summary><span><strong></strong> filters applied</span></summary><button class="c-filter__clear-all">clear all</button><ul class="c-filter__active-list"></ul></details><a href="https://help.escholarship.org/support/solutions/articles/9000148939-using-advanced-search-beta-" class="c-filter__tips">Search tips</a></div><div class="c-refine--has-drawer"><button class="c-refine__button--open">Refine Results</button><button class="c-refine__button--close" hidden="">Back to Results</button><div class="c-refine__drawer--closed"><details class="c-facetbox" open=""><summary class="c-facetbox__summary"><span id="facetbox0">Type of Work</span></summary><fieldset aria-labelledby="facetbox0"><ul class="c-checkbox"><li class=""><input type="checkbox" id="type_of_work-article" class="c-checkbox__input" name="type_of_work" value="article"/><label for="type_of_work-article" class="c-checkbox__label">Article (11)</label></li><li class=""><input type="checkbox" id="type_of_work-monograph" class="c-checkbox__input" name="type_of_work" value="monograph"/><label for="type_of_work-monograph" class="c-checkbox__label">Book (0)</label></li><li class=""><input type="checkbox" id="type_of_work-dissertation" class="c-checkbox__input" name="type_of_work" value="dissertation"/><label for="type_of_work-dissertation" class="c-checkbox__label">Theses (0)</label></li><li class=""><input type="checkbox" id="type_of_work-multimedia" class="c-checkbox__input" name="type_of_work" value="multimedia"/><label for="type_of_work-multimedia" class="c-checkbox__label">Multimedia (0)</label></li></ul></fieldset></details><details class="c-facetbox" open=""><summary class="c-facetbox__summary"><span id="facetbox1">Peer Review</span></summary><fieldset aria-labelledby="facetbox1"><ul class="c-checkbox"><li class=""><input type="checkbox" id="peer_reviewed-1" class="c-checkbox__input" name="peer_reviewed" value="1"/><label for="peer_reviewed-1" class="c-checkbox__label">Peer-reviewed only (11)</label></li></ul></fieldset></details><details class="c-facetbox"><summary class="c-facetbox__summary"><span id="facetbox2">Supplemental Material</span></summary><fieldset aria-labelledby="facetbox2"><ul class="c-checkbox--2column"><li class=""><input type="checkbox" id="supp_file_types-video" class="c-checkbox__input" name="supp_file_types" value="video"/><label for="supp_file_types-video" class="c-checkbox__label">Video (0)</label></li><li class=""><input type="checkbox" id="supp_file_types-audio" class="c-checkbox__input" name="supp_file_types" value="audio"/><label for="supp_file_types-audio" class="c-checkbox__label">Audio (0)</label></li><li class=""><input type="checkbox" id="supp_file_types-images" class="c-checkbox__input" name="supp_file_types" value="images"/><label for="supp_file_types-images" class="c-checkbox__label">Images (0)</label></li><li class=""><input type="checkbox" id="supp_file_types-zip" class="c-checkbox__input" name="supp_file_types" value="zip"/><label for="supp_file_types-zip" class="c-checkbox__label">Zip (0)</label></li><li class=""><input type="checkbox" id="supp_file_types-other_files" class="c-checkbox__input" name="supp_file_types" value="other files"/><label for="supp_file_types-other_files" class="c-checkbox__label">Other files (0)</label></li></ul></fieldset></details><details class="c-facetbox"><summary class="c-facetbox__summary"><span id="facetbox3">Publication Year</span></summary><fieldset aria-labelledby="facetbox3"><div class="c-pubyear"><div class="c-pubyear__field"><label for="c-pubyear__textfield1">From:</label><input type="text" id="c-pubyear__textfield1" name="pub_year_start" maxLength="4" placeholder="1900" value=""/></div><div class="c-pubyear__field"><label for="c-pubyear__textfield2">To:</label><input type="text" id="c-pubyear__textfield2" name="pub_year_end" maxLength="4" placeholder="2025" value=""/></div><button class="c-pubyear__button">Apply</button></div></fieldset></details><details class="c-facetbox"><summary class="c-facetbox__summary"><span id="facetbox4">Campus</span></summary><fieldset aria-labelledby="facetbox4"><ul class="c-checkbox"><li class=""><input type="checkbox" id="campuses-ucb" class="c-checkbox__input" name="campuses" value="ucb"/><label for="campuses-ucb" class="c-checkbox__label">UC Berkeley (0)</label></li><li class=""><input type="checkbox" id="campuses-ucd" class="c-checkbox__input" name="campuses" value="ucd"/><label for="campuses-ucd" class="c-checkbox__label">UC Davis (0)</label></li><li class=""><input type="checkbox" id="campuses-uci" class="c-checkbox__input" name="campuses" value="uci"/><label for="campuses-uci" class="c-checkbox__label">UC Irvine (0)</label></li><li class=""><input type="checkbox" id="campuses-ucla" class="c-checkbox__input" name="campuses" value="ucla"/><label for="campuses-ucla" class="c-checkbox__label">UCLA (9)</label></li><li class=""><input type="checkbox" id="campuses-ucm" class="c-checkbox__input" name="campuses" value="ucm"/><label for="campuses-ucm" class="c-checkbox__label">UC Merced (0)</label></li><li class=""><input type="checkbox" id="campuses-ucr" class="c-checkbox__input" name="campuses" value="ucr"/><label for="campuses-ucr" class="c-checkbox__label">UC Riverside (0)</label></li><li class=""><input type="checkbox" id="campuses-ucsd" class="c-checkbox__input" name="campuses" value="ucsd"/><label for="campuses-ucsd" class="c-checkbox__label">UC San Diego (6)</label></li><li class=""><input type="checkbox" id="campuses-ucsf" class="c-checkbox__input" name="campuses" value="ucsf"/><label for="campuses-ucsf" class="c-checkbox__label">UCSF (3)</label></li><li class=""><input type="checkbox" id="campuses-ucsb" class="c-checkbox__input" name="campuses" value="ucsb"/><label for="campuses-ucsb" class="c-checkbox__label">UC Santa Barbara (1)</label></li><li class=""><input type="checkbox" id="campuses-ucsc" class="c-checkbox__input" name="campuses" value="ucsc"/><label for="campuses-ucsc" class="c-checkbox__label">UC Santa Cruz (1)</label></li><li class=""><input type="checkbox" id="campuses-ucop" class="c-checkbox__input" name="campuses" value="ucop"/><label for="campuses-ucop" class="c-checkbox__label">UC Office of the President (0)</label></li><li class=""><input type="checkbox" id="campuses-lbnl" class="c-checkbox__input" name="campuses" value="lbnl"/><label for="campuses-lbnl" class="c-checkbox__label">Lawrence Berkeley National Laboratory (1)</label></li><li class=""><input type="checkbox" id="campuses-anrcs" class="c-checkbox__input" name="campuses" value="anrcs"/><label for="campuses-anrcs" class="c-checkbox__label">UC Agriculture & Natural Resources (0)</label></li></ul></fieldset></details><details class="c-facetbox"><summary class="c-facetbox__summary"><span id="facetbox5">Department</span></summary><fieldset aria-labelledby="facetbox5"><ul class="c-checkbox"><li class=""><input type="checkbox" id="departments-ucsdsom" class="c-checkbox__input" name="departments" value="ucsdsom"/><label for="departments-ucsdsom" class="c-checkbox__label">School of Medicine (6)</label></li><li class=""><input type="checkbox" id="departments-ucsdpsych" class="c-checkbox__input" name="departments" value="ucsdpsych"/><label for="departments-ucsdpsych" class="c-checkbox__label">Department of Psychiatry, UCSD (3)</label></li><li class=""><input type="checkbox" id="departments-lbnl_cs" class="c-checkbox__input" name="departments" value="lbnl_cs"/><label for="departments-lbnl_cs" class="c-checkbox__label">Computing Sciences (1)</label></li><li class=""><input type="checkbox" id="departments-lbnl_ees" class="c-checkbox__input" name="departments" value="lbnl_ees"/><label for="departments-lbnl_ees" class="c-checkbox__label">Earth & Environmental Sciences (1)</label></li></ul></fieldset></details><details class="c-facetbox"><summary class="c-facetbox__summary"><span id="facetbox6">Journal</span></summary><fieldset aria-labelledby="facetbox6"><ul class="c-checkbox"></ul></fieldset></details><details class="c-facetbox"><summary class="c-facetbox__summary"><span id="facetbox7">Discipline</span></summary><fieldset aria-labelledby="facetbox7"><ul class="c-checkbox"></ul></fieldset></details><details class="c-facetbox"><summary class="c-facetbox__summary"><span id="facetbox8">Reuse License</span></summary><fieldset aria-labelledby="facetbox8"><ul class="c-checkbox"><li class="c-checkbox__attrib-cc-by"><input type="checkbox" id="rights-CC_BY" class="c-checkbox__input" name="rights" value="CC BY"/><label for="rights-CC_BY" class="c-checkbox__label">BY - Attribution required (3)</label></li><li class="c-checkbox__attrib-cc-by-nc-nd"><input type="checkbox" id="rights-CC_BY-NC-ND" class="c-checkbox__input" name="rights" value="CC BY-NC-ND"/><label for="rights-CC_BY-NC-ND" class="c-checkbox__label">BY-NC-ND - Attribution; NonCommercial use; No derivatives (1)</label></li></ul></fieldset></details></div></div><button type="submit" id="facet-form-submit" style="display:none">Search</button></div></aside><main id="maincontent"><section class="o-columnbox1"><header><h2 class="o-columnbox1__heading" aria-live="polite">Scholarly Works (11 results)</h2></header><div class="c-sortpagination"><div class="c-sort"><div class="o-input__droplist1"><label for="c-sort1">Sort By:</label><select name="sort" id="c-sort1" form="facetForm"><option selected="" value="rel">Relevance</option><option value="a-title">A-Z By Title</option><option value="z-title">Z-A By Title</option><option value="a-author">A-Z By Author</option><option value="z-author">Z-A By Author</option><option value="asc">Date Ascending</option><option value="desc">Date Descending</option></select></div><div class="o-input__droplist1 c-sort__page-input"><label for="c-sort2">Show:</label><select name="rows" id="c-sort2" form="facetForm"><option selected="" value="10">10</option><option value="20">20</option></select></div></div><input type="hidden" name="start" form="facetForm" value="0"/><nav class="c-pagination"><ul><li><a href="" aria-label="you are on result set 1" class="c-pagination__item--current">1</a></li><li><a href="" aria-label="go to result set 2" class="c-pagination__item">2</a></li></ul></nav></div><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/8sm5d1xw"><div class="c-clientmarkup">Distinct genetic liability profiles define clinically relevant patient strata across common diseases.</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3ATrastulla%2C%20Lucia">Trastulla, Lucia</a>; </li><li><a href="/search/?q=author%3ADolgalev%2C%20Georgii">Dolgalev, Georgii</a>; </li><li><a href="/search/?q=author%3AMoser%2C%20Sylvain">Moser, Sylvain</a>; </li><li><a href="/search/?q=author%3AJim%C3%A9nez-Barr%C3%B3n%2C%20Laura">Jiménez-Barrón, Laura</a>; </li><li><a href="/search/?q=author%3AAndlauer%2C%20Till">Andlauer, Till</a>; </li><li><a href="/search/?q=author%3Avon%20Scheidt%2C%20Moritz">von Scheidt, Moritz</a>; </li><li><a href="/search/?q=author%3ABudde%2C%20Monika">Budde, Monika</a>; </li><li><a href="/search/?q=author%3AHeilbronner%2C%20Urs">Heilbronner, Urs</a>; </li><li><a href="/search/?q=author%3APapiol%2C%20Sergi">Papiol, Sergi</a>; </li><li><a href="/search/?q=author%3ATeumer%2C%20Alexander">Teumer, Alexander</a>; </li><li><a href="/search/?q=author%3AHomuth%2C%20Georg">Homuth, Georg</a>; </li><li><a href="/search/?q=author%3AV%C3%B6lzke%2C%20Henry">Völzke, Henry</a>; </li><li><a href="/search/?q=author%3AD%C3%B6rr%2C%20Marcus">Dörr, Marcus</a>; </li><li><a href="/search/?q=author%3AFalkai%2C%20Peter">Falkai, Peter</a>; </li><li><a href="/search/?q=author%3ASchulze%2C%20Thomas">Schulze, Thomas</a>; </li><li><a href="/search/?q=author%3AGagneur%2C%20Julien">Gagneur, Julien</a>; </li><li><a href="/search/?q=author%3AIorio%2C%20Francesco">Iorio, Francesco</a>; </li><li><a href="/search/?q=author%3AM%C3%BCller-Myhsok%2C%20Bertram">Müller-Myhsok, Bertram</a>; </li><li><a href="/search/?q=author%3ASchunkert%2C%20Heribert">Schunkert, Heribert</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3AZiller%2C%20Michael">Ziller, Michael</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucla_postprints">UCLA Previously Published Works</a> (2024)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup">Stratified medicine holds great promise to tailor treatment to the needs of individual patients. While genetics holds great potential to aid patient stratification, it remains a major challenge to operationalize complex genetic risk factor profiles to deconstruct clinical heterogeneity. Contemporary approaches to this problem rely on polygenic risk scores (PRS), which provide only limited clinical utility and lack a clear biological foundation. To overcome these limitations, we develop the CASTom-iGEx approach to stratify individuals based on the aggregated impact of their genetic risk factor profiles on tissue specific gene expression levels. The paradigmatic application of this approach to coronary artery disease or schizophrenia patient cohorts identified diverse strata or biotypes. These biotypes are characterized by distinct endophenotype profiles as well as clinical parameters and are fundamentally distinct from PRS based groupings. In stark contrast to the latter, the CASTom-iGEx strategy discovers biologically meaningful and clinically actionable patient subgroups, where complex genetic liabilities are not randomly distributed across individuals but rather converge onto distinct disease relevant biological processes. These results support the notion of different patient biotypes characterized by partially distinct pathomechanisms. Thus, the universally applicable approach presented here has the potential to constitute an important component of future personalized medicine paradigms.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/8sm5d1xw"><img src="/cms-assets/2dc260d3b4c7e970982a365bd838259e0c53519a0c16b354654e60ff8b60da8d" alt="Cover page: Distinct genetic liability profiles define clinically relevant patient strata across common diseases."/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/9t608449"><div class="c-clientmarkup">GWAS of Suicide Attempt in Psychiatric Disorders and Association With Major Depression Polygenic Risk Scores</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3AMullins%2C%20Niamh">Mullins, Niamh</a>; </li><li><a href="/search/?q=author%3ABigdeli%2C%20Tim%20B">Bigdeli, Tim B</a>; </li><li><a href="/search/?q=author%3AB%C3%B8rglum%2C%20Anders%20D">Børglum, Anders D</a>; </li><li><a href="/search/?q=author%3AColeman%2C%20Jonathan%20RI">Coleman, Jonathan RI</a>; </li><li><a href="/search/?q=author%3ADemontis%2C%20Ditte">Demontis, Ditte</a>; </li><li><a href="/search/?q=author%3AMehta%2C%20Divya">Mehta, Divya</a>; </li><li><a href="/search/?q=author%3APower%2C%20Robert%20A">Power, Robert A</a>; </li><li><a href="/search/?q=author%3ARipke%2C%20Stephan">Ripke, Stephan</a>; </li><li><a href="/search/?q=author%3AStahl%2C%20Eli%20A">Stahl, Eli A</a>; </li><li><a href="/search/?q=author%3AStarnawska%2C%20Anna">Starnawska, Anna</a>; </li><li><a href="/search/?q=author%3AAnjorin%2C%20Adebayo">Anjorin, Adebayo</a>; </li><li><a href="/search/?q=author%3ACorvin%2C%20Aiden">Corvin, Aiden</a>; </li><li><a href="/search/?q=author%3ASanders%2C%20Alan%20R">Sanders, Alan R</a>; </li><li><a href="/search/?q=author%3AForstner%2C%20Andreas%20J">Forstner, Andreas J</a>; </li><li><a href="/search/?q=author%3AReif%2C%20Andreas">Reif, Andreas</a>; </li><li><a href="/search/?q=author%3AKoller%2C%20Anna%20C">Koller, Anna C</a>; </li><li><a href="/search/?q=author%3A%C5%9Awi%C4%85tkowska%2C%20Beata">Świątkowska, Beata</a>; </li><li><a href="/search/?q=author%3ABaune%2C%20Bernhard%20T">Baune, Bernhard T</a>; </li><li><a href="/search/?q=author%3AM%C3%BCller-Myhsok%2C%20Bertram">Müller-Myhsok, Bertram</a>; </li><li><a href="/search/?q=author%3APenninx%2C%20Brenda%20WJH">Penninx, Brenda WJH</a>; </li><li><a href="/search/?q=author%3APato%2C%20Carlos">Pato, Carlos</a>; </li><li><a href="/search/?q=author%3AZai%2C%20Clement">Zai, Clement</a>; </li><li><a href="/search/?q=author%3ARujescu%2C%20Dan">Rujescu, Dan</a>; </li><li><a href="/search/?q=author%3AHougaard%2C%20David%20M">Hougaard, David M</a>; </li><li><a href="/search/?q=author%3AQuested%2C%20Digby">Quested, Digby</a>; </li><li><a href="/search/?q=author%3ALevinson%2C%20Douglas%20F">Levinson, Douglas F</a>; </li><li><a href="/search/?q=author%3ABinder%2C%20Elisabeth%20B">Binder, Elisabeth B</a>; </li><li><a href="/search/?q=author%3AByrne%2C%20Enda%20M">Byrne, Enda M</a>; </li><li><a href="/search/?q=author%3AAgerbo%2C%20Esben">Agerbo, Esben</a>; </li><li><a href="/search/?q=author%3AStreit%2C%20Fabian">Streit, Fabian</a>; </li><li><a href="/search/?q=author%3AMayoral%2C%20Fermin">Mayoral, Fermin</a>; </li><li><a href="/search/?q=author%3ABellivier%2C%20Frank">Bellivier, Frank</a>; </li><li><a href="/search/?q=author%3ADegenhardt%2C%20Franziska">Degenhardt, Franziska</a>; </li><li><a href="/search/?q=author%3ABreen%2C%20Gerome">Breen, Gerome</a>; </li><li><a href="/search/?q=author%3AMorken%2C%20Gunnar">Morken, Gunnar</a>; </li><li><a href="/search/?q=author%3ATurecki%2C%20Gustavo">Turecki, Gustavo</a>; </li><li><a href="/search/?q=author%3ARouleau%2C%20Guy%20A">Rouleau, Guy A</a>; </li><li><a href="/search/?q=author%3AGrabe%2C%20Hans%20J">Grabe, Hans J</a>; </li><li><a href="/search/?q=author%3AV%C3%B6lzke%2C%20Henry">Völzke, Henry</a>; </li><li><a href="/search/?q=author%3AJones%2C%20Ian">Jones, Ian</a>; </li><li><a href="/search/?q=author%3AGiegling%2C%20Ina">Giegling, Ina</a>; </li><li><a href="/search/?q=author%3AAgartz%2C%20Ingrid">Agartz, Ingrid</a>; </li><li><a href="/search/?q=author%3AMelle%2C%20Ingrid">Melle, Ingrid</a>; </li><li><a href="/search/?q=author%3ALawrence%2C%20Jacob">Lawrence, Jacob</a>; </li><li><a href="/search/?q=author%3AWalters%2C%20James%20TR">Walters, James TR</a>; </li><li><a href="/search/?q=author%3AStrohmaier%2C%20Jana">Strohmaier, Jana</a>; </li><li><a href="/search/?q=author%3AShi%2C%20Jianxin">Shi, Jianxin</a>; </li><li><a href="/search/?q=author%3AHauser%2C%20Joanna">Hauser, Joanna</a>; </li><li><a href="/search/?q=author%3ABiernacka%2C%20Joanna%20M">Biernacka, Joanna M</a>; </li><li><a href="/search/?q=author%3AVincent%2C%20John%20B">Vincent, John B</a>; </li><li><a href="/search/?q=author%3AKelsoe%2C%20John">Kelsoe, John</a>; </li><li><a href="/search/?q=author%3AStrauss%2C%20John%20S">Strauss, John S</a>; </li><li><a href="/search/?q=author%3ALissowska%2C%20Jolanta">Lissowska, Jolanta</a>; </li><li><a href="/search/?q=author%3APimm%2C%20Jonathan">Pimm, Jonathan</a>; </li><li><a href="/search/?q=author%3ASmoller%2C%20Jordan%20W">Smoller, Jordan W</a>; </li><li><a href="/search/?q=author%3AGuzman-Parra%2C%20Jos%C3%A9">Guzman-Parra, José</a>; </li><li><a href="/search/?q=author%3ABerger%2C%20Klaus">Berger, Klaus</a>; </li><li><a href="/search/?q=author%3AScott%2C%20Laura%20J">Scott, Laura J</a>; </li><li><a href="/search/?q=author%3AJones%2C%20Lisa%20A">Jones, Lisa A</a>; </li><li><a href="/search/?q=author%3AAzevedo%2C%20M%20Helena">Azevedo, M Helena</a>; </li><li><a href="/search/?q=author%3ATrzaskowski%2C%20Maciej">Trzaskowski, Maciej</a>; </li><li><a href="/search/?q=author%3AKogevinas%2C%20Manolis">Kogevinas, Manolis</a>; </li><li><a href="/search/?q=author%3ARietschel%2C%20Marcella">Rietschel, Marcella</a>; </li><li><a href="/search/?q=author%3ABoks%2C%20Marco">Boks, Marco</a>; </li><li><a href="/search/?q=author%3AIsing%2C%20Marcus">Ising, Marcus</a>; </li><li><a href="/search/?q=author%3AGrigoroiu-Serbanescu%2C%20Maria">Grigoroiu-Serbanescu, Maria</a>; </li><li><a href="/search/?q=author%3AHamshere%2C%20Marian%20L">Hamshere, Marian L</a>; </li><li><a href="/search/?q=author%3ALeboyer%2C%20Marion">Leboyer, Marion</a>; </li><li><a href="/search/?q=author%3AFrye%2C%20Mark">Frye, Mark</a>; </li><li><a href="/search/?q=author%3AN%C3%B6then%2C%20Markus%20M">Nöthen, Markus M</a>; </li><li><a href="/search/?q=author%3AAlda%2C%20Martin">Alda, Martin</a>; </li><li><a href="/search/?q=author%3APreisig%2C%20Martin">Preisig, Martin</a>; </li><li><a href="/search/?q=author%3ANordentoft%2C%20Merete">Nordentoft, Merete</a>; </li><li><a href="/search/?q=author%3ABoehnke%2C%20Michael">Boehnke, Michael</a>; </li><li><a href="/search/?q=author%3AO%E2%80%99Donovan%2C%20Michael%20C">O’Donovan, Michael C</a>; </li><li><a href="/search/?q=author%3AOwen%2C%20Michael%20J">Owen, Michael J</a>; </li><li><a href="/search/?q=author%3APato%2C%20Michele%20T">Pato, Michele T</a>; </li><li><a href="/search/?q=author%3ARenteria%2C%20Miguel%20E">Renteria, Miguel E</a>; </li><li><a href="/search/?q=author%3ABudde%2C%20Monika">Budde, Monika</a>; </li><li><a href="/search/?q=author%3AWeissman%2C%20Myrna%20M">Weissman, Myrna M</a>; </li><li><a href="/search/?q=author%3AWray%2C%20Naomi%20R">Wray, Naomi R</a>; </li><li><a href="/search/?q=author%3ABass%2C%20Nicholas">Bass, Nicholas</a>; </li><li><a href="/search/?q=author%3ACraddock%2C%20Nicholas">Craddock, Nicholas</a>; </li><li><a href="/search/?q=author%3ASmeland%2C%20Olav%20B">Smeland, Olav B</a>; </li><li><a href="/search/?q=author%3AAndreassen%2C%20Ole%20A">Andreassen, Ole A</a>; </li><li><a href="/search/?q=author%3AMors%2C%20Ole">Mors, Ole</a>; </li><li><a href="/search/?q=author%3AGejman%2C%20Pablo%20V">Gejman, Pablo V</a>; </li><li><a href="/search/?q=author%3ASklar%2C%20Pamela">Sklar, Pamela</a>; </li><li><a href="/search/?q=author%3AMcGrath%2C%20Patrick">McGrath, Patrick</a>; </li><li><a href="/search/?q=author%3AHoffmann%2C%20Per">Hoffmann, Per</a>; </li><li><a href="/search/?q=author%3AMcGuffin%2C%20Peter">McGuffin, Peter</a>; </li><li><a href="/search/?q=author%3ALee%2C%20Phil%20H">Lee, Phil H</a>; </li><li><a href="/search/?q=author%3AMortensen%2C%20Preben%20Bo">Mortensen, Preben Bo</a>; </li><li><a href="/search/?q=author%3AKahn%2C%20Ren%C3%A9%20S">Kahn, René S</a>; </li><li><a href="/search/?q=author%3AOphoff%2C%20Roel%20A">Ophoff, Roel A</a>; </li><li><a href="/search/?q=author%3AAdolfsson%2C%20Rolf">Adolfsson, Rolf</a>; </li><li><a href="/search/?q=author%3AVan%20der%20Auwera%2C%20Sandra">Van der Auwera, Sandra</a>; </li><li><a href="/search/?q=author%3ADjurovic%2C%20Srdjan">Djurovic, Srdjan</a>; </li><li><a href="/search/?q=author%3AKloiber%2C%20Stefan">Kloiber, Stefan</a>; </li><li><a href="/search/?q=author%3AHeilmann-Heimbach%2C%20Stefanie">Heilmann-Heimbach, Stefanie</a>; </li><li><a href="/search/?q=author%3AJamain%2C%20St%C3%A9phane">Jamain, Stéphane</a>; </li><li><a href="/search/?q=author%3AHamilton%2C%20Steven%20P">Hamilton, Steven P</a>; </li><li><a href="/search/?q=author%3AMcElroy%2C%20Susan%20L">McElroy, Susan L</a>; </li><li><a href="/search/?q=author%3ALucae%2C%20Susanne">Lucae, Susanne</a>; </li><li><a href="/search/?q=author%3ACichon%2C%20Sven">Cichon, Sven</a>; </li><li><a href="/search/?q=author%3ASchulze%2C%20Thomas%20G">Schulze, Thomas G</a>; </li><li><a href="/search/?q=author%3AHansen%2C%20Thomas">Hansen, Thomas</a>; </li><li><a href="/search/?q=author%3AWerge%2C%20Thomas">Werge, Thomas</a>; </li><li><a href="/search/?q=author%3AAir%2C%20Tracy%20M">Air, Tracy M</a>; </li><li><a href="/search/?q=author%3ANimgaonkar%2C%20Vishwajit">Nimgaonkar, Vishwajit</a>; </li><li><a href="/search/?q=author%3AAppadurai%2C%20Vivek">Appadurai, Vivek</a>; </li><li><a href="/search/?q=author%3ACahn%2C%20Wiepke">Cahn, Wiepke</a>; </li><li><a href="/search/?q=author%3AMilaneschi%2C%20Yuri">Milaneschi, Yuri</a>; </li><li><a href="/search/?q=author%3AFanous%2C%20Ayman%20H">Fanous, Ayman H</a>; </li><li><a href="/search/?q=author%3AKendler%2C%20Kenneth%20S">Kendler, Kenneth S</a>; </li><li><a href="/search/?q=author%3AMcQuillin%2C%20Andrew">McQuillin, Andrew</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3ALewis%2C%20Cathryn%20M">Lewis, Cathryn M</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucla_postprints">UCLA Previously Published Works</a> (2019)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup"><h3>Objective</h3>More than 90% of people who attempt suicide have a psychiatric diagnosis; however, twin and family studies suggest that the genetic etiology of suicide attempt is partially distinct from that of the psychiatric disorders themselves. The authors present the largest genome-wide association study (GWAS) on suicide attempt, using cohorts of individuals with major depressive disorder, bipolar disorder, and schizophrenia from the Psychiatric Genomics Consortium.<h3>Methods</h3>The samples comprised 1,622 suicide attempters and 8,786 nonattempters with major depressive disorder; 3,264 attempters and 5,500 nonattempters with bipolar disorder; and 1,683 attempters and 2,946 nonattempters with schizophrenia. A GWAS on suicide attempt was performed by comparing attempters to nonattempters with each disorder, followed by a meta-analysis across disorders. Polygenic risk scoring was used to investigate the genetic relationship between suicide attempt and the psychiatric disorders.<h3>Results</h3>Three genome-wide significant loci for suicide attempt were found: one associated with suicide attempt in major depressive disorder, one associated with suicide attempt in bipolar disorder, and one in the meta-analysis of suicide attempt in mood disorders. These associations were not replicated in independent mood disorder cohorts from the UK Biobank and iPSYCH. No significant associations were found in the meta-analysis of all three disorders. Polygenic risk scores for major depression were significantly associated with suicide attempt in major depressive disorder (R<sup>2</sup>=0.25%), bipolar disorder (R<sup>2</sup>=0.24%), and schizophrenia (R<sup>2</sup>=0.40%).<h3>Conclusions</h3>This study provides new information on genetic associations and demonstrates that genetic liability for major depression increases risk for suicide attempt across psychiatric disorders. Further collaborative efforts to increase sample size may help to robustly identify genetic associations and provide biological insights into the etiology of suicide attempt.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/9t608449"><img src="/cms-assets/5f4977adc268c42176d5480d0574b17edc7c25d83729ab884316505f36645c08" alt="Cover page: GWAS of Suicide Attempt in Psychiatric Disorders and Association With Major Depression Polygenic Risk Scores"/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/5t32r0fp"><div class="c-clientmarkup">Characterisation of age and polarity at onset in bipolar disorder.</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3AKalman%2C%20Janos%20L">Kalman, Janos L</a>; </li><li><a href="/search/?q=author%3AOlde%20Loohuis%2C%20Loes%20M">Olde Loohuis, Loes M</a>; </li><li><a href="/search/?q=author%3AVreeker%2C%20Annabel">Vreeker, Annabel</a>; </li><li><a href="/search/?q=author%3AMcQuillin%2C%20Andrew">McQuillin, Andrew</a>; </li><li><a href="/search/?q=author%3AStahl%2C%20Eli%20A">Stahl, Eli A</a>; </li><li><a href="/search/?q=author%3ARuderfer%2C%20Douglas">Ruderfer, Douglas</a>; </li><li><a href="/search/?q=author%3AGrigoroiu-Serbanescu%2C%20Maria">Grigoroiu-Serbanescu, Maria</a>; </li><li><a href="/search/?q=author%3APanagiotaropoulou%2C%20Georgia">Panagiotaropoulou, Georgia</a>; </li><li><a href="/search/?q=author%3ARipke%2C%20Stephan">Ripke, Stephan</a>; </li><li><a href="/search/?q=author%3ABigdeli%2C%20Tim%20B">Bigdeli, Tim B</a>; </li><li><a href="/search/?q=author%3AStein%2C%20Frederike">Stein, Frederike</a>; </li><li><a href="/search/?q=author%3AMeller%2C%20Tina">Meller, Tina</a>; </li><li><a href="/search/?q=author%3AMeinert%2C%20Susanne">Meinert, Susanne</a>; </li><li><a href="/search/?q=author%3APelin%2C%20Helena">Pelin, Helena</a>; </li><li><a href="/search/?q=author%3AStreit%2C%20Fabian">Streit, Fabian</a>; </li><li><a href="/search/?q=author%3APapiol%2C%20Sergi">Papiol, Sergi</a>; </li><li><a href="/search/?q=author%3AAdams%2C%20Mark%20J">Adams, Mark J</a>; </li><li><a href="/search/?q=author%3AAdolfsson%2C%20Rolf">Adolfsson, Rolf</a>; </li><li><a href="/search/?q=author%3AAdorjan%2C%20Kristina">Adorjan, Kristina</a>; </li><li><a href="/search/?q=author%3AAgartz%2C%20Ingrid">Agartz, Ingrid</a>; </li><li><a href="/search/?q=author%3AAminoff%2C%20Sofie%20R">Aminoff, Sofie R</a>; </li><li><a href="/search/?q=author%3AAnderson-Schmidt%2C%20Heike">Anderson-Schmidt, Heike</a>; </li><li><a href="/search/?q=author%3AAndreassen%2C%20Ole%20A">Andreassen, Ole A</a>; </li><li><a href="/search/?q=author%3AArdau%2C%20Raffaella">Ardau, Raffaella</a>; </li><li><a href="/search/?q=author%3AAubry%2C%20Jean-Michel">Aubry, Jean-Michel</a>; </li><li><a href="/search/?q=author%3ABalaban%2C%20Ceylan">Balaban, Ceylan</a>; </li><li><a href="/search/?q=author%3ABass%2C%20Nicholas">Bass, Nicholas</a>; </li><li><a href="/search/?q=author%3ABaune%2C%20Bernhard%20T">Baune, Bernhard T</a>; </li><li><a href="/search/?q=author%3ABellivier%2C%20Frank">Bellivier, Frank</a>; </li><li><a href="/search/?q=author%3ABenabarre%2C%20Antoni">Benabarre, Antoni</a>; </li><li><a href="/search/?q=author%3ABengesser%2C%20Susanne">Bengesser, Susanne</a>; </li><li><a href="/search/?q=author%3ABerrettini%2C%20Wade%20H">Berrettini, Wade H</a>; </li><li><a href="/search/?q=author%3ABoks%2C%20Marco%20P">Boks, Marco P</a>; </li><li><a href="/search/?q=author%3ABromet%2C%20Evelyn%20J">Bromet, Evelyn J</a>; </li><li><a href="/search/?q=author%3ABrosch%2C%20Katharina">Brosch, Katharina</a>; </li><li><a href="/search/?q=author%3ABudde%2C%20Monika">Budde, Monika</a>; </li><li><a href="/search/?q=author%3AByerley%2C%20William">Byerley, William</a>; </li><li><a href="/search/?q=author%3ACervantes%2C%20Pablo">Cervantes, Pablo</a>; </li><li><a href="/search/?q=author%3AChillotti%2C%20Catina">Chillotti, Catina</a>; </li><li><a href="/search/?q=author%3ACichon%2C%20Sven">Cichon, Sven</a>; </li><li><a href="/search/?q=author%3AClark%2C%20Scott%20R">Clark, Scott R</a>; </li><li><a href="/search/?q=author%3AComes%2C%20Ashley%20L">Comes, Ashley L</a>; </li><li><a href="/search/?q=author%3ACorvin%2C%20Aiden">Corvin, Aiden</a>; </li><li><a href="/search/?q=author%3ACoryell%2C%20William">Coryell, William</a>; </li><li><a href="/search/?q=author%3ACraddock%2C%20Nick">Craddock, Nick</a>; </li><li><a href="/search/?q=author%3ACraig%2C%20David%20W">Craig, David W</a>; </li><li><a href="/search/?q=author%3ACroarkin%2C%20Paul%20E">Croarkin, Paul E</a>; </li><li><a href="/search/?q=author%3ACruceanu%2C%20Cristiana">Cruceanu, Cristiana</a>; </li><li><a href="/search/?q=author%3ACzerski%2C%20Piotr%20M">Czerski, Piotr M</a>; </li><li><a href="/search/?q=author%3ADalkner%2C%20Nina">Dalkner, Nina</a>; </li><li><a href="/search/?q=author%3ADannlowski%2C%20Udo">Dannlowski, Udo</a>; </li><li><a href="/search/?q=author%3ADegenhardt%2C%20Franziska">Degenhardt, Franziska</a>; </li><li><a href="/search/?q=author%3ADel%20Zompo%2C%20Maria">Del Zompo, Maria</a>; </li><li><a href="/search/?q=author%3ADePaulo%2C%20J%20Raymond">DePaulo, J Raymond</a>; </li><li><a href="/search/?q=author%3ADjurovic%2C%20Srdjan">Djurovic, Srdjan</a>; </li><li><a href="/search/?q=author%3AEdenberg%2C%20Howard%20J">Edenberg, Howard J</a>; </li><li><a href="/search/?q=author%3AEissa%2C%20Mariam%20Al">Eissa, Mariam Al</a>; </li><li><a href="/search/?q=author%3AElvs%C3%A5shagen%2C%20Torbj%C3%B8rn">Elvsåshagen, Torbjørn</a>; </li><li><a href="/search/?q=author%3AEtain%2C%20Bruno">Etain, Bruno</a>; </li><li><a href="/search/?q=author%3AFanous%2C%20Ayman%20H">Fanous, Ayman H</a>; </li><li><a href="/search/?q=author%3AFellendorf%2C%20Frederike">Fellendorf, Frederike</a>; </li><li><a href="/search/?q=author%3AFiorentino%2C%20Alessia">Fiorentino, Alessia</a>; </li><li><a href="/search/?q=author%3AForstner%2C%20Andreas%20J">Forstner, Andreas J</a>; </li><li><a href="/search/?q=author%3AFrye%2C%20Mark%20A">Frye, Mark A</a>; </li><li><a href="/search/?q=author%3AFullerton%2C%20Janice%20M">Fullerton, Janice M</a>; </li><li><a href="/search/?q=author%3AGade%2C%20Katrin">Gade, Katrin</a>; </li><li><a href="/search/?q=author%3AGarnham%2C%20Julie">Garnham, Julie</a>; </li><li><a href="/search/?q=author%3AGershon%2C%20Elliot">Gershon, Elliot</a>; </li><li><a href="/search/?q=author%3AGill%2C%20Michael">Gill, Michael</a>; </li><li><a href="/search/?q=author%3AGoes%2C%20Fernando%20S">Goes, Fernando S</a>; </li><li><a href="/search/?q=author%3AGordon-Smith%2C%20Katherine">Gordon-Smith, Katherine</a>; </li><li><a href="/search/?q=author%3AGrof%2C%20Paul">Grof, Paul</a>; </li><li><a href="/search/?q=author%3AGuzman-Parra%2C%20Jose">Guzman-Parra, Jose</a>; </li><li><a href="/search/?q=author%3AHahn%2C%20Tim">Hahn, Tim</a>; </li><li><a href="/search/?q=author%3AHasler%2C%20Roland">Hasler, Roland</a>; </li><li><a href="/search/?q=author%3AHeilbronner%2C%20Maria">Heilbronner, Maria</a>; </li><li><a href="/search/?q=author%3AHeilbronner%2C%20Urs">Heilbronner, Urs</a>; </li><li><a href="/search/?q=author%3AJamain%2C%20Stephane">Jamain, Stephane</a>; </li><li><a href="/search/?q=author%3AJimenez%2C%20Esther">Jimenez, Esther</a>; </li><li><a href="/search/?q=author%3AJones%2C%20Ian">Jones, Ian</a>; </li><li><a href="/search/?q=author%3AJones%2C%20Lisa">Jones, Lisa</a>; </li><li><a href="/search/?q=author%3AJonsson%2C%20Lina">Jonsson, Lina</a>; </li><li><a href="/search/?q=author%3AKahn%2C%20Rene%20S">Kahn, Rene S</a>; </li><li><a href="/search/?q=author%3AKelsoe%2C%20John%20R">Kelsoe, John R</a>; </li><li><a href="/search/?q=author%3AKennedy%2C%20James%20L">Kennedy, James L</a>; </li><li><a href="/search/?q=author%3AKircher%2C%20Tilo">Kircher, Tilo</a>; </li><li><a href="/search/?q=author%3AKirov%2C%20George">Kirov, George</a>; </li><li><a href="/search/?q=author%3AKittel-Schneider%2C%20Sarah">Kittel-Schneider, Sarah</a>; </li><li><a href="/search/?q=author%3AKl%C3%B6hn-Saghatolislam%2C%20Farah">Klöhn-Saghatolislam, Farah</a>; </li><li><a href="/search/?q=author%3AKnowles%2C%20James%20A">Knowles, James A</a>; </li><li><a href="/search/?q=author%3AKranz%2C%20Thorsten%20M">Kranz, Thorsten M</a>; </li><li><a href="/search/?q=author%3ALagerberg%2C%20Trine%20Vik">Lagerberg, Trine Vik</a>; </li><li><a href="/search/?q=author%3ALanden%2C%20Mikael">Landen, Mikael</a>; </li><li><a href="/search/?q=author%3ALawson%2C%20William%20B">Lawson, William B</a>; </li><li><a href="/search/?q=author%3ALeboyer%2C%20Marion">Leboyer, Marion</a>; </li><li><a href="/search/?q=author%3ALi%2C%20Qingqin%20S">Li, Qingqin S</a>; </li><li><a href="/search/?q=author%3AMaj%2C%20Mario">Maj, Mario</a>; </li><li><a href="/search/?q=author%3AMalaspina%2C%20Dolores">Malaspina, Dolores</a>; </li><li><a href="/search/?q=author%3AManchia%2C%20Mirko">Manchia, Mirko</a>; </li><li><a href="/search/?q=author%3AMayoral%2C%20Fermin">Mayoral, Fermin</a>; </li><li><a href="/search/?q=author%3AMcElroy%2C%20Susan%20L">McElroy, Susan L</a>; </li><li><a href="/search/?q=author%3AMcInnis%2C%20Melvin%20G">McInnis, Melvin G</a>; </li><li><a href="/search/?q=author%3AMcIntosh%2C%20Andrew%20M">McIntosh, Andrew M</a>; </li><li><a href="/search/?q=author%3AMedeiros%2C%20Helena">Medeiros, Helena</a>; </li><li><a href="/search/?q=author%3AMelle%2C%20Ingrid">Melle, Ingrid</a>; </li><li><a href="/search/?q=author%3AMilanova%2C%20Vihra">Milanova, Vihra</a>; </li><li><a href="/search/?q=author%3AMitchell%2C%20Philip%20B">Mitchell, Philip B</a>; </li><li><a href="/search/?q=author%3AMonteleone%2C%20Palmiero">Monteleone, Palmiero</a>; </li><li><a href="/search/?q=author%3AMonteleone%2C%20Alessio%20Maria">Monteleone, Alessio Maria</a>; </li><li><a href="/search/?q=author%3AN%C3%B6then%2C%20Markus%20M">Nöthen, Markus M</a>; </li><li><a href="/search/?q=author%3ANovak%2C%20Tomas">Novak, Tomas</a>; </li><li><a href="/search/?q=author%3ANurnberger%2C%20John%20I">Nurnberger, John I</a>; </li><li><a href="/search/?q=author%3AO'Brien%2C%20Niamh">O'Brien, Niamh</a>; </li><li><a href="/search/?q=author%3AO'Connell%2C%20Kevin%20S">O'Connell, Kevin S</a>; </li><li><a href="/search/?q=author%3AO'Donovan%2C%20Claire">O'Donovan, Claire</a>; </li><li><a href="/search/?q=author%3AO'Donovan%2C%20Michael%20C">O'Donovan, Michael C</a>; </li><li><a href="/search/?q=author%3AOpel%2C%20Nils">Opel, Nils</a>; </li><li><a href="/search/?q=author%3AOrtiz%2C%20Abigail">Ortiz, Abigail</a>; </li><li><a href="/search/?q=author%3AOwen%2C%20Michael%20J">Owen, Michael J</a>; </li><li><a href="/search/?q=author%3AP%C3%A5lsson%2C%20Erik">Pålsson, Erik</a>; </li><li><a href="/search/?q=author%3APato%2C%20Carlos">Pato, Carlos</a>; </li><li><a href="/search/?q=author%3APato%2C%20Michele%20T">Pato, Michele T</a>; </li><li><a href="/search/?q=author%3APawlak%2C%20Joanna">Pawlak, Joanna</a>; </li><li><a href="/search/?q=author%3APfarr%2C%20Julia-Katharina">Pfarr, Julia-Katharina</a>; </li><li><a href="/search/?q=author%3APisanu%2C%20Claudia">Pisanu, Claudia</a>; </li><li><a href="/search/?q=author%3APotash%2C%20James%20B">Potash, James B</a>; </li><li><a href="/search/?q=author%3ARapaport%2C%20Mark%20H">Rapaport, Mark H</a>; </li><li><a href="/search/?q=author%3AReich-Erkelenz%2C%20Daniela">Reich-Erkelenz, Daniela</a>; </li><li><a href="/search/?q=author%3AReif%2C%20Andreas">Reif, Andreas</a>; </li><li><a href="/search/?q=author%3AReininghaus%2C%20Eva">Reininghaus, Eva</a>; </li><li><a href="/search/?q=author%3ARepple%2C%20Jonathan">Repple, Jonathan</a>; </li><li><a href="/search/?q=author%3ARichard-Lepouriel%2C%20H%C3%A9l%C3%A8ne">Richard-Lepouriel, Hélène</a>; </li><li><a href="/search/?q=author%3ARietschel%2C%20Marcella">Rietschel, Marcella</a>; </li><li><a href="/search/?q=author%3ARingwald%2C%20Kai">Ringwald, Kai</a>; </li><li><a href="/search/?q=author%3ARoberts%2C%20Gloria">Roberts, Gloria</a>; </li><li><a href="/search/?q=author%3ARouleau%2C%20Guy">Rouleau, Guy</a>; </li><li><a href="/search/?q=author%3ASchaupp%2C%20Sabrina">Schaupp, Sabrina</a>; </li><li><a href="/search/?q=author%3AScheftner%2C%20William%20A">Scheftner, William A</a>; </li><li><a href="/search/?q=author%3ASchmitt%2C%20Simon">Schmitt, Simon</a>; </li><li><a href="/search/?q=author%3ASchofield%2C%20Peter%20R">Schofield, Peter R</a>; </li><li><a href="/search/?q=author%3ASchubert%2C%20K%20Oliver">Schubert, K Oliver</a>; </li><li><a href="/search/?q=author%3ASchulte%2C%20Eva%20C">Schulte, Eva C</a>; </li><li><a href="/search/?q=author%3ASchweizer%2C%20Barbara">Schweizer, Barbara</a>; </li><li><a href="/search/?q=author%3ASenner%2C%20Fanny">Senner, Fanny</a>; </li><li><a href="/search/?q=author%3ASeverino%2C%20Giovanni">Severino, Giovanni</a>; </li><li><a href="/search/?q=author%3ASharp%2C%20Sally">Sharp, Sally</a>; </li><li><a href="/search/?q=author%3ASlaney%2C%20Claire">Slaney, Claire</a>; </li><li><a href="/search/?q=author%3ASmeland%2C%20Olav%20B">Smeland, Olav B</a>; </li><li><a href="/search/?q=author%3ASobell%2C%20Janet%20L">Sobell, Janet L</a>; </li><li><a href="/search/?q=author%3ASquassina%2C%20Alessio">Squassina, Alessio</a>; </li><li><a href="/search/?q=author%3AStopkova%2C%20Pavla">Stopkova, Pavla</a>; </li><li><a href="/search/?q=author%3AStrauss%2C%20John">Strauss, John</a>; </li><li><a href="/search/?q=author%3ATortorella%2C%20Alfonso">Tortorella, Alfonso</a>; </li><li><a href="/search/?q=author%3ATurecki%2C%20Gustavo">Turecki, Gustavo</a>; </li><li><a href="/search/?q=author%3ATwarowska-Hauser%2C%20Joanna">Twarowska-Hauser, Joanna</a>; </li><li><a href="/search/?q=author%3AVeldic%2C%20Marin">Veldic, Marin</a>; </li><li><a href="/search/?q=author%3AVieta%2C%20Eduard">Vieta, Eduard</a>; </li><li><a href="/search/?q=author%3AVincent%2C%20John%20B">Vincent, John B</a>; </li><li><a href="/search/?q=author%3AXu%2C%20Wei">Xu, Wei</a>; </li><li><a href="/search/?q=author%3AZai%2C%20Clement%20C">Zai, Clement C</a>; </li><li><a href="/search/?q=author%3AZandi%2C%20Peter%20P">Zandi, Peter P</a>; </li><li><a href="/search/?q=author%3APsychiatric%20Genomics%20Consortium%20(PGC)%20Bipolar%20Disorder%20Working%20Group">Psychiatric Genomics Consortium (PGC) Bipolar Disorder Working Group</a>; </li><li><a href="/search/?q=author%3AInternational%20Consortium%20on%20Lithium%20Genetics%20(ConLiGen)">International Consortium on Lithium Genetics (ConLiGen)</a>; </li><li><a href="/search/?q=author%3AColombia-US%20Cross%20Disorder%20Collaboration%20in%20Psychiatric%20Genetics">Colombia-US Cross Disorder Collaboration in Psychiatric Genetics</a>; </li><li><a href="/search/?q=author%3ADi%20Florio%2C%20Arianna">Di Florio, Arianna</a>; </li><li><a href="/search/?q=author%3ASmoller%2C%20Jordan%20W">Smoller, Jordan W</a>; </li><li><a href="/search/?q=author%3ABiernacka%2C%20Joanna%20M">Biernacka, Joanna M</a>; </li><li><a href="/search/?q=author%3AMcMahon%2C%20Francis%20J">McMahon, Francis J</a>; </li><li><a href="/search/?q=author%3AAlda%2C%20Martin">Alda, Martin</a>; </li><li><a href="/search/?q=author%3AM%C3%BCller-Myhsok%2C%20Bertram">Müller-Myhsok, Bertram</a>; </li><li><a href="/search/?q=author%3AKoutsouleris%2C%20Nikolaos">Koutsouleris, Nikolaos</a>; </li><li><a href="/search/?q=author%3AFalkai%2C%20Peter">Falkai, Peter</a>; </li><li><a href="/search/?q=author%3AFreimer%2C%20Nelson%20B">Freimer, Nelson B</a>; </li><li><a href="/search/?q=author%3AAndlauer%2C%20Till%20FM">Andlauer, Till FM</a>; </li><li><a href="/search/?q=author%3ASchulze%2C%20Thomas%20G">Schulze, Thomas G</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3AOphoff%2C%20Roel%20A">Ophoff, Roel A</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucla_postprints">UCLA Previously Published Works</a> (2021)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup"><h3>Background</h3>Studying phenotypic and genetic characteristics of age at onset (AAO) and polarity at onset (PAO) in bipolar disorder can provide new insights into disease pathology and facilitate the development of screening tools.<h3>Aims</h3>To examine the genetic architecture of AAO and PAO and their association with bipolar disorder disease characteristics.<h3>Method</h3>Genome-wide association studies (GWASs) and polygenic score (PGS) analyses of AAO (n = 12 977) and PAO (n = 6773) were conducted in patients with bipolar disorder from 34 cohorts and a replication sample (n = 2237). The association of onset with disease characteristics was investigated in two of these cohorts.<h3>Results</h3>Earlier AAO was associated with a higher probability of psychotic symptoms, suicidality, lower educational attainment, not living together and fewer episodes. Depressive onset correlated with suicidality and manic onset correlated with delusions and manic episodes. Systematic differences in AAO between cohorts and continents of origin were observed. This was also reflected in single-nucleotide variant-based heritability estimates, with higher heritabilities for stricter onset definitions. Increased PGS for autism spectrum disorder (β = -0.34 years, s.e. = 0.08), major depression (β = -0.34 years, s.e. = 0.08), schizophrenia (β = -0.39 years, s.e. = 0.08), and educational attainment (β = -0.31 years, s.e. = 0.08) were associated with an earlier AAO. The AAO GWAS identified one significant locus, but this finding did not replicate. Neither GWAS nor PGS analyses yielded significant associations with PAO.<h3>Conclusions</h3>AAO and PAO are associated with indicators of bipolar disorder severity. Individuals with an earlier onset show an increased polygenic liability for a broad spectrum of psychiatric traits. Systematic differences in AAO across cohorts, continents and phenotype definitions introduce significant heterogeneity, affecting analyses.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/5t32r0fp"><img src="/cms-assets/3776f443a45d095a895a09bb8f73fc04cdaf5cf52371bdab68576f063f6f7dcf" alt="Cover page: Characterisation of age and polarity at onset in bipolar disorder."/></a><a href="https://creativecommons.org/licenses/by/4.0/" class="c-scholworks__license"><img class="c-lazyimage" data-src="/images/cc-by-small.svg" alt="Creative Commons 'BY' version 4.0 license"/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/6ws3t9gd"><div class="c-clientmarkup">Association of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder.</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3AAmare%2C%20Azmeraw">Amare, Azmeraw</a>; </li><li><a href="/search/?q=author%3AThalamuthu%2C%20Anbupalam">Thalamuthu, Anbupalam</a>; </li><li><a href="/search/?q=author%3ASchubert%2C%20Klaus">Schubert, Klaus</a>; </li><li><a href="/search/?q=author%3AFullerton%2C%20Janice">Fullerton, Janice</a>; </li><li><a href="/search/?q=author%3AAhmed%2C%20Muktar">Ahmed, Muktar</a>; </li><li><a href="/search/?q=author%3AHartmann%2C%20Simon">Hartmann, Simon</a>; </li><li><a href="/search/?q=author%3APapiol%2C%20Sergi">Papiol, Sergi</a>; </li><li><a href="/search/?q=author%3AHeilbronner%2C%20Urs">Heilbronner, Urs</a>; </li><li><a href="/search/?q=author%3ADegenhardt%2C%20Franziska">Degenhardt, Franziska</a>; </li><li><a href="/search/?q=author%3ATekola-Ayele%2C%20Fasil">Tekola-Ayele, Fasil</a>; </li><li><a href="/search/?q=author%3AHou%2C%20Liping">Hou, Liping</a>; </li><li><a href="/search/?q=author%3AHsu%2C%20Yi-Hsiang">Hsu, Yi-Hsiang</a>; </li><li><a href="/search/?q=author%3AShekhtman%2C%20Tatyana">Shekhtman, Tatyana</a>; </li><li><a href="/search/?q=author%3AAdli%2C%20Mazda">Adli, Mazda</a>; </li><li><a href="/search/?q=author%3AAkula%2C%20Nirmala">Akula, Nirmala</a>; </li><li><a href="/search/?q=author%3AAkiyama%2C%20Kazufumi">Akiyama, Kazufumi</a>; </li><li><a href="/search/?q=author%3AArdau%2C%20Raffaella">Ardau, Raffaella</a>; </li><li><a href="/search/?q=author%3AArias%2C%20B%C3%A1rbara">Arias, Bárbara</a>; </li><li><a href="/search/?q=author%3AAubry%2C%20Jean-Michel">Aubry, Jean-Michel</a>; </li><li><a href="/search/?q=author%3AHasler%2C%20Roland">Hasler, Roland</a>; </li><li><a href="/search/?q=author%3ARichard-Lepouriel%2C%20H%C3%A9l%C3%A8ne">Richard-Lepouriel, Hélène</a>; </li><li><a href="/search/?q=author%3APerroud%2C%20Nader">Perroud, Nader</a>; </li><li><a href="/search/?q=author%3ABacklund%2C%20Lena">Backlund, Lena</a>; </li><li><a href="/search/?q=author%3ABhattacharjee%2C%20Abesh">Bhattacharjee, Abesh</a>; </li><li><a href="/search/?q=author%3ABellivier%2C%20Frank">Bellivier, Frank</a>; </li><li><a href="/search/?q=author%3ABenabarre%2C%20Antonio">Benabarre, Antonio</a>; </li><li><a href="/search/?q=author%3ABengesser%2C%20Susanne">Bengesser, Susanne</a>; </li><li><a href="/search/?q=author%3ABiernacka%2C%20Joanna">Biernacka, Joanna</a>; </li><li><a href="/search/?q=author%3ABirner%2C%20Armin">Birner, Armin</a>; </li><li><a href="/search/?q=author%3AMarie-Claire%2C%20Cynthia">Marie-Claire, Cynthia</a>; </li><li><a href="/search/?q=author%3ACervantes%2C%20Pablo">Cervantes, Pablo</a>; </li><li><a href="/search/?q=author%3AChen%2C%20Hsi-Chung">Chen, Hsi-Chung</a>; </li><li><a href="/search/?q=author%3AChillotti%2C%20Caterina">Chillotti, Caterina</a>; </li><li><a href="/search/?q=author%3ACichon%2C%20Sven">Cichon, Sven</a>; </li><li><a href="/search/?q=author%3ACruceanu%2C%20Cristiana">Cruceanu, Cristiana</a>; </li><li><a href="/search/?q=author%3ACzerski%2C%20Piotr">Czerski, Piotr</a>; </li><li><a href="/search/?q=author%3ADalkner%2C%20Nina">Dalkner, Nina</a>; </li><li><a href="/search/?q=author%3ADel%20Zompo%2C%20Maria">Del Zompo, Maria</a>; </li><li><a href="/search/?q=author%3ADePaulo%2C%20J">DePaulo, J</a>; </li><li><a href="/search/?q=author%3A%C3%89tain%2C%20Bruno">Étain, Bruno</a>; </li><li><a href="/search/?q=author%3AJamain%2C%20Stephane">Jamain, Stephane</a>; </li><li><a href="/search/?q=author%3AFalkai%2C%20Peter">Falkai, Peter</a>; </li><li><a href="/search/?q=author%3AForstner%2C%20Andreas">Forstner, Andreas</a>; </li><li><a href="/search/?q=author%3AFrisen%2C%20Louise">Frisen, Louise</a>; </li><li><a href="/search/?q=author%3AFrye%2C%20Mark">Frye, Mark</a>; </li><li><a href="/search/?q=author%3AGard%2C%20S%C3%A9bastien">Gard, Sébastien</a>; </li><li><a href="/search/?q=author%3AGarnham%2C%20Julie">Garnham, Julie</a>; </li><li><a href="/search/?q=author%3AGoes%2C%20Fernando">Goes, Fernando</a>; </li><li><a href="/search/?q=author%3AGrigoroiu-Serbanescu%2C%20Maria">Grigoroiu-Serbanescu, Maria</a>; </li><li><a href="/search/?q=author%3AFallgatter%2C%20Andreas">Fallgatter, Andreas</a>; </li><li><a href="/search/?q=author%3AStegmaier%2C%20Sophia">Stegmaier, Sophia</a>; </li><li><a href="/search/?q=author%3AEthofer%2C%20Thomas">Ethofer, Thomas</a>; </li><li><a href="/search/?q=author%3ABiere%2C%20Silvia">Biere, Silvia</a>; </li><li><a href="/search/?q=author%3APetrova%2C%20Kristiyana">Petrova, Kristiyana</a>; </li><li><a href="/search/?q=author%3ASchuster%2C%20Ceylan">Schuster, Ceylan</a>; </li><li><a href="/search/?q=author%3AAdorjan%2C%20Kristina">Adorjan, Kristina</a>; </li><li><a href="/search/?q=author%3ABudde%2C%20Monika">Budde, Monika</a>; </li><li><a href="/search/?q=author%3AHeilbronner%2C%20Maria">Heilbronner, Maria</a>; </li><li><a href="/search/?q=author%3AKalman%2C%20Janos">Kalman, Janos</a>; </li><li><a href="/search/?q=author%3AKohshour%2C%20Mojtaba">Kohshour, Mojtaba</a>; </li><li><a href="/search/?q=author%3AReich-Erkelenz%2C%20Daniela">Reich-Erkelenz, Daniela</a>; </li><li><a href="/search/?q=author%3ASchaupp%2C%20Sabrina">Schaupp, Sabrina</a>; </li><li><a href="/search/?q=author%3ASchulte%2C%20Eva">Schulte, Eva</a>; </li><li><a href="/search/?q=author%3ASenner%2C%20Fanny">Senner, Fanny</a>; </li><li><a href="/search/?q=author%3AVogl%2C%20Thomas">Vogl, Thomas</a>; </li><li><a href="/search/?q=author%3AAnghelescu%2C%20Ion-George">Anghelescu, Ion-George</a>; </li><li><a href="/search/?q=author%3AArolt%2C%20Volker">Arolt, Volker</a>; </li><li><a href="/search/?q=author%3ADannlowski%2C%20Udo">Dannlowski, Udo</a>; </li><li><a href="/search/?q=author%3ADietrich%2C%20Detlef">Dietrich, Detlef</a>; </li><li><a href="/search/?q=author%3AFigge%2C%20Christian">Figge, Christian</a>; </li><li><a href="/search/?q=author%3AJ%C3%A4ger%2C%20Markus">Jäger, Markus</a>; </li><li><a href="/search/?q=author%3ALang%2C%20Fabian">Lang, Fabian</a>; </li><li><a href="/search/?q=author%3AJuckel%2C%20Georg">Juckel, Georg</a>; </li><li><a href="/search/?q=author%3AKonrad%2C%20Carsten">Konrad, Carsten</a>; </li><li><a href="/search/?q=author%3AReimer%2C%20Jens">Reimer, Jens</a>; </li><li><a href="/search/?q=author%3ASchmau%C3%9F%2C%20Max">Schmauß, Max</a>; </li><li><a href="/search/?q=author%3ASchmitt%2C%20Andrea">Schmitt, Andrea</a>; </li><li><a href="/search/?q=author%3ASpitzer%2C%20Carsten">Spitzer, Carsten</a>; </li><li><a href="/search/?q=author%3Avon%20Hagen%2C%20Martin">von Hagen, Martin</a>; </li><li><a href="/search/?q=author%3AWiltfang%2C%20Jens">Wiltfang, Jens</a>; </li><li><a href="/search/?q=author%3AZimmermann%2C%20J%C3%B6rg">Zimmermann, Jörg</a>; </li><li><a href="/search/?q=author%3AAndlauer%2C%20Till">Andlauer, Till</a>; </li><li><a href="/search/?q=author%3AFischer%2C%20Andre">Fischer, Andre</a>; </li><li><a href="/search/?q=author%3ABermpohl%2C%20Felix">Bermpohl, Felix</a>; </li><li><a href="/search/?q=author%3ARitter%2C%20Philipp">Ritter, Philipp</a>; </li><li><a href="/search/?q=author%3AMatura%2C%20Silke">Matura, Silke</a>; </li><li><a href="/search/?q=author%3AGryaznova%2C%20Anna">Gryaznova, Anna</a>; </li><li><a href="/search/?q=author%3AFalkenberg%2C%20Irina">Falkenberg, Irina</a>; </li><li><a href="/search/?q=author%3AYildiz%2C%20C%C3%BCneyt">Yildiz, Cüneyt</a>; </li><li><a href="/search/?q=author%3AKircher%2C%20Tilo">Kircher, Tilo</a>; </li><li><a href="/search/?q=author%3ASchmidt%2C%20Julia">Schmidt, Julia</a>; </li><li><a href="/search/?q=author%3AKoch%2C%20Marius">Koch, Marius</a>; </li><li><a href="/search/?q=author%3AGade%2C%20Kathrin">Gade, Kathrin</a>; </li><li><a href="/search/?q=author%3ATrost%2C%20Sarah">Trost, Sarah</a>; </li><li><a href="/search/?q=author%3AHaussleiter%2C%20Ida">Haussleiter, Ida</a>; </li><li><a href="/search/?q=author%3ALambert%2C%20Martin">Lambert, Martin</a>; </li><li><a href="/search/?q=author%3ARohenkohl%2C%20Anja">Rohenkohl, Anja</a>; </li><li><a href="/search/?q=author%3AKraft%2C%20Vivien">Kraft, Vivien</a>; </li><li><a href="/search/?q=author%3AGrof%2C%20Paul">Grof, Paul</a>; </li><li><a href="/search/?q=author%3AHashimoto%2C%20Ryota">Hashimoto, Ryota</a>; </li><li><a href="/search/?q=author%3AHauser%2C%20Joanna">Hauser, Joanna</a>; </li><li><a href="/search/?q=author%3AHerms%2C%20Stefan">Herms, Stefan</a>; </li><li><a href="/search/?q=author%3AHoffmann%2C%20Per">Hoffmann, Per</a>; </li><li><a href="/search/?q=author%3AJim%C3%A9nez%2C%20Esther">Jiménez, Esther</a>; </li><li><a href="/search/?q=author%3AKahn%2C%20Jean-Pierre">Kahn, Jean-Pierre</a>; </li><li><a href="/search/?q=author%3AKassem%2C%20Layla">Kassem, Layla</a>; </li><li><a href="/search/?q=author%3AKuo%2C%20Po-Hsiu">Kuo, Po-Hsiu</a>; </li><li><a href="/search/?q=author%3AKato%2C%20Tadafumi">Kato, Tadafumi</a>; </li><li><a href="/search/?q=author%3AKelsoe%2C%20John">Kelsoe, John</a>; </li><li><a href="/search/?q=author%3AKittel-Schneider%2C%20Sarah">Kittel-Schneider, Sarah</a>; </li><li><a href="/search/?q=author%3AFerensztajn-Rochowiak%2C%20Ewa">Ferensztajn-Rochowiak, Ewa</a>; </li><li><a href="/search/?q=author%3AK%C3%B6nig%2C%20Barbara">König, Barbara</a>; </li><li><a href="/search/?q=author%3AKusumi%2C%20Ichiro">Kusumi, Ichiro</a>; </li><li><a href="/search/?q=author%3ALaje%2C%20Gonzalo">Laje, Gonzalo</a>; </li><li><a href="/search/?q=author%3ALand%C3%A9n%2C%20Mikael">Landén, Mikael</a>; </li><li><a href="/search/?q=author%3ALavebratt%2C%20Catharina">Lavebratt, Catharina</a>; </li><li><a href="/search/?q=author%3ALeboyer%2C%20Marion">Leboyer, Marion</a>; </li><li><a href="/search/?q=author%3ALeckband%2C%20Susan">Leckband, Susan</a>; </li><li><a href="/search/?q=author%3AMcElroy%2C%20Susan">McElroy, Susan</a>; </li><li><a href="/search/?q=author%3AColom%2C%20Francesc">Colom, Francesc</a>; </li><li><a href="/search/?q=author%3AMillischer%2C%20Vincent">Millischer, Vincent</a>; </li><li><a href="/search/?q=author%3AMitjans%2C%20Marina">Mitjans, Marina</a>; </li><li><a href="/search/?q=author%3AMondimore%2C%20Francis">Mondimore, Francis</a>; </li><li><a href="/search/?q=author%3AMonteleone%2C%20Palmiero">Monteleone, Palmiero</a>; </li><li><a href="/search/?q=author%3ANievergelt%2C%20Caroline">Nievergelt, Caroline</a>; </li><li><a href="/search/?q=author%3AN%C3%B6then%2C%20Markus">Nöthen, Markus</a>; </li><li><a href="/search/?q=author%3ANov%C3%A1k%2C%20Tomas">Novák, Tomas</a>; </li><li><a href="/search/?q=author%3AODonovan%2C%20Claire">ODonovan, Claire</a>; </li><li><a href="/search/?q=author%3AOzaki%2C%20Norio">Ozaki, Norio</a>; </li><li><a href="/search/?q=author%3APfennig%2C%20Andrea">Pfennig, Andrea</a>; </li><li><a href="/search/?q=author%3APisanu%2C%20Claudia">Pisanu, Claudia</a>; </li><li><a href="/search/?q=author%3APotash%2C%20James">Potash, James</a>; </li><li><a href="/search/?q=author%3AReif%2C%20Andreas">Reif, Andreas</a>; </li><li><a href="/search/?q=author%3AReininghaus%2C%20Eva">Reininghaus, Eva</a>; </li><li><a href="/search/?q=author%3ARouleau%2C%20Guy">Rouleau, Guy</a>; </li><li><a href="/search/?q=author%3ARybakowski%2C%20Janusz">Rybakowski, Janusz</a>; </li><li><a href="/search/?q=author%3ASchalling%2C%20Martin">Schalling, Martin</a>; </li><li><a href="/search/?q=author%3ASchofield%2C%20Peter">Schofield, Peter</a>; </li><li><a href="/search/?q=author%3ASchweizer%2C%20Barbara">Schweizer, Barbara</a>; </li><li><a href="/search/?q=author%3ASeverino%2C%20Giovanni">Severino, Giovanni</a>; </li><li><a href="/search/?q=author%3AShilling%2C%20Paul">Shilling, Paul</a>; </li><li><a href="/search/?q=author%3AShimoda%2C%20Katzutaka">Shimoda, Katzutaka</a>; </li><li><a href="/search/?q=author%3ASimhandl%2C%20Christian">Simhandl, Christian</a>; </li><li><a href="/search/?q=author%3ASlaney%2C%20Claire">Slaney, Claire</a>; </li><li><a href="/search/?q=author%3ASquassina%2C%20Alessio">Squassina, Alessio</a>; </li><li><a href="/search/?q=author%3AStamm%2C%20Thomas">Stamm, Thomas</a>; </li><li><a href="/search/?q=author%3AStopkova%2C%20Pavla">Stopkova, Pavla</a>; </li><li><a href="/search/?q=author%3AMaj%2C%20Mario">Maj, Mario</a>; </li><li><a href="/search/?q=author%3ATurecki%2C%20Gustavo">Turecki, Gustavo</a>; </li><li><a href="/search/?q=author%3AVieta%2C%20Eduard">Vieta, Eduard</a>; </li><li><a href="/search/?q=author%3AVeeh%2C%20Julia">Veeh, Julia</a>; </li><li><a href="/search/?q=author%3AWitt%2C%20Stephanie">Witt, Stephanie</a>; </li><li><a href="/search/?q=author%3AWright%2C%20Adam">Wright, Adam</a>; </li><li><a href="/search/?q=author%3AZandi%2C%20Peter">Zandi, Peter</a>; </li><li><a href="/search/?q=author%3AMitchell%2C%20Philip">Mitchell, Philip</a>; </li><li><a href="/search/?q=author%3ABauer%2C%20Michael">Bauer, Michael</a>; </li><li><a href="/search/?q=author%3AAlda%2C%20Martin">Alda, Martin</a>; </li><li><a href="/search/?q=author%3ARietschel%2C%20Marcella">Rietschel, Marcella</a>; </li><li><a href="/search/?q=author%3AMcMahon%2C%20Francis">McMahon, Francis</a>; </li><li><a href="/search/?q=author%3ASchulze%2C%20Thomas">Schulze, Thomas</a>; </li><li><a href="/search/?q=author%3AClark%2C%20Scott">Clark, Scott</a>; </li><li><a href="/search/?q=author%3ABaune%2C%20Bernhard">Baune, Bernhard</a>; </li><li><a href="/search/?q=author%3ATortorella%2C%20Alfonso">Tortorella, Alfonso</a>; </li><li><a href="/search/?q=author%3AManchia%2C%20Mirko">Manchia, Mirko</a>; </li><li><a href="/search/?q=author%3AMartinsson%2C%20Lina">Martinsson, Lina</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3AMccarthy%2C%20Michael">Mccarthy, Michael</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucsd_postprints">UC San Diego Previously Published Works</a> (2023)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup">Lithium is regarded as the first-line treatment for bipolar disorder (BD), a severe and disabling mental health disorder that affects about 1% of the population worldwide. Nevertheless, lithium is not consistently effective, with only 30% of patients showing a favorable response to treatment. To provide personalized treatment options for bipolar patients, it is essential to identify prediction biomarkers such as polygenic scores. In this study, we developed a polygenic score for lithium treatment response (Li+PGS) in patients with BD. To gain further insights into lithiums possible molecular mechanism of action, we performed a genome-wide gene-based analysis. Using polygenic score modeling, via methods incorporating Bayesian regression and continuous shrinkage priors, Li+PGS was developed in the International Consortium of Lithium Genetics cohort (ConLi+Gen: N = 2367) and replicated in the combined PsyCourse (N = 89) and BipoLife (N = 102) studies. The associations of Li+PGS and lithium treatment response - defined in a continuous ALDA scale and a categorical outcome (good response vs. poor response) were tested using regression models, each adjusted for the covariates: age, sex, and the first four genetic principal components. Statistical significance was determined at P < 0.05. Li+PGS was positively associated with lithium treatment response in the ConLi+Gen cohort, in both the categorical (P = 9.8 × 10-12, R2 = 1.9%) and continuous (P = 6.4 × 10-9, R2 = 2.6%) outcomes. Compared to bipolar patients in the 1st decile of the risk distribution, individuals in the 10th decile had 3.47-fold (95%CI: 2.22-5.47) higher odds of responding favorably to lithium. The results were replicated in the independent cohorts for the categorical treatment outcome (P = 3.9 × 10-4, R2 = 0.9%), but not for the continuous outcome (P = 0.13). Gene-based analyses revealed 36 candidate genes that are enriched in biological pathways controlled by glutamate and acetylcholine. Li+PGS may be useful in the development of pharmacogenomic testing strategies by enabling a classification of bipolar patients according to their response to treatment.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/6ws3t9gd"><img src="/cms-assets/b3b7ee042377f97c019e83efcd6ec0b8418835c611916f12f78b7907c479d9fd" alt="Cover page: Association of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder."/></a><a href="https://creativecommons.org/licenses/by/4.0/" class="c-scholworks__license"><img class="c-lazyimage" data-src="/images/cc-by-small.svg" alt="Creative Commons 'BY' version 4.0 license"/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/3q8267gj"><div class="c-clientmarkup">GWAS Meta-Analysis of Suicide Attempt: Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors.</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3ADocherty%2C%20Anna">Docherty, Anna</a>; </li><li><a href="/search/?q=author%3AMullins%2C%20Niamh">Mullins, Niamh</a>; </li><li><a href="/search/?q=author%3AAshley-Koch%2C%20Allison">Ashley-Koch, Allison</a>; </li><li><a href="/search/?q=author%3AQin%2C%20Xuejun">Qin, Xuejun</a>; </li><li><a href="/search/?q=author%3AColeman%2C%20Jonathan">Coleman, Jonathan</a>; </li><li><a href="/search/?q=author%3AShabalin%2C%20Andrey">Shabalin, Andrey</a>; </li><li><a href="/search/?q=author%3AKang%2C%20JooEun">Kang, JooEun</a>; </li><li><a href="/search/?q=author%3AMurnyak%2C%20Balasz">Murnyak, Balasz</a>; </li><li><a href="/search/?q=author%3AWendt%2C%20Frank">Wendt, Frank</a>; </li><li><a href="/search/?q=author%3AAdams%2C%20Mark">Adams, Mark</a>; </li><li><a href="/search/?q=author%3ACampos%2C%20Adrian">Campos, Adrian</a>; </li><li><a href="/search/?q=author%3ADiBlasi%2C%20Emily">DiBlasi, Emily</a>; </li><li><a href="/search/?q=author%3AFullerton%2C%20Janice">Fullerton, Janice</a>; </li><li><a href="/search/?q=author%3AKranzler%2C%20Henry">Kranzler, Henry</a>; </li><li><a href="/search/?q=author%3ABakian%2C%20Amanda">Bakian, Amanda</a>; </li><li><a href="/search/?q=author%3AMonson%2C%20Eric">Monson, Eric</a>; </li><li><a href="/search/?q=author%3ARenter%C3%ADa%2C%20Miguel">Rentería, Miguel</a>; </li><li><a href="/search/?q=author%3AWalss-Bass%2C%20Consuelo">Walss-Bass, Consuelo</a>; </li><li><a href="/search/?q=author%3AAndreassen%2C%20Ole">Andreassen, Ole</a>; </li><li><a href="/search/?q=author%3ABehera%2C%20Chittaranjan">Behera, Chittaranjan</a>; </li><li><a href="/search/?q=author%3ABulik%2C%20Cynthia">Bulik, Cynthia</a>; </li><li><a href="/search/?q=author%3AEdenberg%2C%20Howard">Edenberg, Howard</a>; </li><li><a href="/search/?q=author%3AKessler%2C%20Ronald">Kessler, Ronald</a>; </li><li><a href="/search/?q=author%3AMann%2C%20J">Mann, J</a>; </li><li><a href="/search/?q=author%3ANurnberger%2C%20John">Nurnberger, John</a>; </li><li><a href="/search/?q=author%3APistis%2C%20Giorgio">Pistis, Giorgio</a>; </li><li><a href="/search/?q=author%3AStreit%2C%20Fabian">Streit, Fabian</a>; </li><li><a href="/search/?q=author%3AUrsano%2C%20Robert">Ursano, Robert</a>; </li><li><a href="/search/?q=author%3APolimanti%2C%20Renato">Polimanti, Renato</a>; </li><li><a href="/search/?q=author%3ADennis%2C%20Michelle">Dennis, Michelle</a>; </li><li><a href="/search/?q=author%3AGarrett%2C%20Melanie">Garrett, Melanie</a>; </li><li><a href="/search/?q=author%3AHair%2C%20Lauren">Hair, Lauren</a>; </li><li><a href="/search/?q=author%3AHarvey%2C%20Philip">Harvey, Philip</a>; </li><li><a href="/search/?q=author%3AHauser%2C%20Elizabeth">Hauser, Elizabeth</a>; </li><li><a href="/search/?q=author%3AHauser%2C%20Michael">Hauser, Michael</a>; </li><li><a href="/search/?q=author%3AHuffman%2C%20Jennifer">Huffman, Jennifer</a>; </li><li><a href="/search/?q=author%3AJacobson%2C%20Daniel">Jacobson, Daniel</a>; </li><li><a href="/search/?q=author%3AMadduri%2C%20Ravi">Madduri, Ravi</a>; </li><li><a href="/search/?q=author%3AMcMahon%2C%20Benjamin">McMahon, Benjamin</a>; </li><li><a href="/search/?q=author%3AOslin%2C%20David">Oslin, David</a>; </li><li><a href="/search/?q=author%3ATrafton%2C%20Jodie">Trafton, Jodie</a>; </li><li><a href="/search/?q=author%3AAwasthi%2C%20Swapnil">Awasthi, Swapnil</a>; </li><li><a href="/search/?q=author%3ABerrettini%2C%20Wade">Berrettini, Wade</a>; </li><li><a href="/search/?q=author%3ABohus%2C%20Martin">Bohus, Martin</a>; </li><li><a href="/search/?q=author%3AChang%2C%20Xiao">Chang, Xiao</a>; </li><li><a href="/search/?q=author%3AChen%2C%20Hsi-Chung">Chen, Hsi-Chung</a>; </li><li><a href="/search/?q=author%3AChen%2C%20Wei">Chen, Wei</a>; </li><li><a href="/search/?q=author%3AChristensen%2C%20Erik">Christensen, Erik</a>; </li><li><a href="/search/?q=author%3ACrow%2C%20Scott">Crow, Scott</a>; </li><li><a href="/search/?q=author%3ADuriez%2C%20Philibert">Duriez, Philibert</a>; </li><li><a href="/search/?q=author%3AEdwards%2C%20Alexis">Edwards, Alexis</a>; </li><li><a href="/search/?q=author%3AFern%C3%A1ndez-Aranda%2C%20Fernando">Fernández-Aranda, Fernando</a>; </li><li><a href="/search/?q=author%3AGalfalvy%2C%20Hanga">Galfalvy, Hanga</a>; </li><li><a href="/search/?q=author%3AGandal%2C%20Michael">Gandal, Michael</a>; </li><li><a href="/search/?q=author%3AGorwood%2C%20Philip">Gorwood, Philip</a>; </li><li><a href="/search/?q=author%3AGuo%2C%20Yiran">Guo, Yiran</a>; </li><li><a href="/search/?q=author%3AHafferty%2C%20Jonathan">Hafferty, Jonathan</a>; </li><li><a href="/search/?q=author%3AHakonarson%2C%20Hakon">Hakonarson, Hakon</a>; </li><li><a href="/search/?q=author%3AHalmi%2C%20Katherine">Halmi, Katherine</a>; </li><li><a href="/search/?q=author%3AHishimoto%2C%20Akitoyo">Hishimoto, Akitoyo</a>; </li><li><a href="/search/?q=author%3AJain%2C%20Sonia">Jain, Sonia</a>; </li><li><a href="/search/?q=author%3AJamain%2C%20St%C3%A9phane">Jamain, Stéphane</a>; </li><li><a href="/search/?q=author%3AJim%C3%A9nez-Murcia%2C%20Susana">Jiménez-Murcia, Susana</a>; </li><li><a href="/search/?q=author%3AJohnson%2C%20Craig">Johnson, Craig</a>; </li><li><a href="/search/?q=author%3AKaplan%2C%20Allan">Kaplan, Allan</a>; </li><li><a href="/search/?q=author%3AKaye%2C%20Walter">Kaye, Walter</a>; </li><li><a href="/search/?q=author%3AKeel%2C%20Pamela">Keel, Pamela</a>; </li><li><a href="/search/?q=author%3AKennedy%2C%20James">Kennedy, James</a>; </li><li><a href="/search/?q=author%3AKim%2C%20Minsoo">Kim, Minsoo</a>; </li><li><a href="/search/?q=author%3AKlump%2C%20Kelly">Klump, Kelly</a>; </li><li><a href="/search/?q=author%3ALevey%2C%20Daniel">Levey, Daniel</a>; </li><li><a href="/search/?q=author%3ALi%2C%20Dong">Li, Dong</a>; </li><li><a href="/search/?q=author%3ALiao%2C%20Shih-Cheng">Liao, Shih-Cheng</a>; </li><li><a href="/search/?q=author%3ALieb%2C%20Klaus">Lieb, Klaus</a>; </li><li><a href="/search/?q=author%3ALilenfeld%2C%20Lisa">Lilenfeld, Lisa</a>; </li><li><a href="/search/?q=author%3AMarshall%2C%20Christian">Marshall, Christian</a>; </li><li><a href="/search/?q=author%3AMitchell%2C%20James">Mitchell, James</a>; </li><li><a href="/search/?q=author%3AOkazaki%2C%20Satoshi">Okazaki, Satoshi</a>; </li><li><a href="/search/?q=author%3AOtsuka%2C%20Ikuo">Otsuka, Ikuo</a>; </li><li><a href="/search/?q=author%3APinto%2C%20Dalila">Pinto, Dalila</a>; </li><li><a href="/search/?q=author%3APowers%2C%20Abigail">Powers, Abigail</a>; </li><li><a href="/search/?q=author%3ARamoz%2C%20Nicolas">Ramoz, Nicolas</a>; </li><li><a href="/search/?q=author%3ARipke%2C%20Stephan">Ripke, Stephan</a>; </li><li><a href="/search/?q=author%3ARoepke%2C%20Stefan">Roepke, Stefan</a>; </li><li><a href="/search/?q=author%3ARozanov%2C%20Vsevolod">Rozanov, Vsevolod</a>; </li><li><a href="/search/?q=author%3AScherer%2C%20Stephen">Scherer, Stephen</a>; </li><li><a href="/search/?q=author%3ASchmahl%2C%20Christian">Schmahl, Christian</a>; </li><li><a href="/search/?q=author%3ASokolowski%2C%20Marcus">Sokolowski, Marcus</a>; </li><li><a href="/search/?q=author%3AStarnawska%2C%20Anna">Starnawska, Anna</a>; </li><li><a href="/search/?q=author%3AStrober%2C%20Michael">Strober, Michael</a>; </li><li><a href="/search/?q=author%3ASu%2C%20Mei-Hsin">Su, Mei-Hsin</a>; </li><li><a href="/search/?q=author%3AThornton%2C%20Laura">Thornton, Laura</a>; </li><li><a href="/search/?q=author%3ATreasure%2C%20Janet">Treasure, Janet</a>; </li><li><a href="/search/?q=author%3AWare%2C%20Erin">Ware, Erin</a>; </li><li><a href="/search/?q=author%3AWatson%2C%20Hunna">Watson, Hunna</a>; </li><li><a href="/search/?q=author%3AWitt%2C%20Stephanie">Witt, Stephanie</a>; </li><li><a href="/search/?q=author%3AWoodside%2C%20D">Woodside, D</a>; </li><li><a href="/search/?q=author%3AYilmaz%2C%20Zeynep">Yilmaz, Zeynep</a>; </li><li><a href="/search/?q=author%3AZillich%2C%20Lea">Zillich, Lea</a>; </li><li><a href="/search/?q=author%3AAdolfsson%2C%20Rolf">Adolfsson, Rolf</a>; </li><li><a href="/search/?q=author%3AAgartz%2C%20Ingrid">Agartz, Ingrid</a>; </li><li><a href="/search/?q=author%3AAlda%2C%20Martin">Alda, Martin</a>; </li><li><a href="/search/?q=author%3AAlfredsson%2C%20Lars">Alfredsson, Lars</a>; </li><li><a href="/search/?q=author%3AAppadurai%2C%20Vivek">Appadurai, Vivek</a>; </li><li><a href="/search/?q=author%3AArtigas%2C%20Mar%C3%ADa">Artigas, María</a>; </li><li><a href="/search/?q=author%3AVan%20der%20Auwera%2C%20Sandra">Van der Auwera, Sandra</a>; </li><li><a href="/search/?q=author%3AAzevedo%2C%20M">Azevedo, M</a>; </li><li><a href="/search/?q=author%3ABass%2C%20Nicholas">Bass, Nicholas</a>; </li><li><a href="/search/?q=author%3ABau%2C%20Claiton">Bau, Claiton</a>; </li><li><a href="/search/?q=author%3ABaune%2C%20Bernhard">Baune, Bernhard</a>; </li><li><a href="/search/?q=author%3ABellivier%2C%20Frank">Bellivier, Frank</a>; </li><li><a href="/search/?q=author%3ABerger%2C%20Klaus">Berger, Klaus</a>; </li><li><a href="/search/?q=author%3ABiernacka%2C%20Joanna">Biernacka, Joanna</a>; </li><li><a href="/search/?q=author%3ABigdeli%2C%20Tim">Bigdeli, Tim</a>; </li><li><a href="/search/?q=author%3ABinder%2C%20Elisabeth">Binder, Elisabeth</a>; </li><li><a href="/search/?q=author%3ABoehnke%2C%20Michael">Boehnke, Michael</a>; </li><li><a href="/search/?q=author%3ABoks%2C%20Marco">Boks, Marco</a>; </li><li><a href="/search/?q=author%3ABraff%2C%20David">Braff, David</a>; </li><li><a href="/search/?q=author%3ABryant%2C%20Richard">Bryant, Richard</a>; </li><li><a href="/search/?q=author%3ABudde%2C%20Monika">Budde, Monika</a>; </li><li><a href="/search/?q=author%3AByrne%2C%20Enda">Byrne, Enda</a>; </li><li><a href="/search/?q=author%3ACahn%2C%20Wiepke">Cahn, Wiepke</a>; </li><li><a href="/search/?q=author%3ACastelao%2C%20Enrique">Castelao, Enrique</a>; </li><li><a href="/search/?q=author%3ACervilla%2C%20Jorge">Cervilla, Jorge</a>; </li><li><a href="/search/?q=author%3AChaumette%2C%20Boris">Chaumette, Boris</a>; </li><li><a href="/search/?q=author%3ACorvin%2C%20Aiden">Corvin, Aiden</a>; </li><li><a href="/search/?q=author%3ACraddock%2C%20Nicholas">Craddock, Nicholas</a>; </li><li><a href="/search/?q=author%3ADjurovic%2C%20Srdjan">Djurovic, Srdjan</a>; </li><li><a href="/search/?q=author%3AFoo%2C%20Jerome">Foo, Jerome</a>; </li><li><a href="/search/?q=author%3AForstner%2C%20Andreas">Forstner, Andreas</a>; </li><li><a href="/search/?q=author%3AFrye%2C%20Mark">Frye, Mark</a>; </li><li><a href="/search/?q=author%3AGatt%2C%20Justine">Gatt, Justine</a>; </li><li><a href="/search/?q=author%3AGiegling%2C%20Ina">Giegling, Ina</a>; </li><li><a href="/search/?q=author%3AGrabe%2C%20Hans">Grabe, Hans</a>; </li><li><a href="/search/?q=author%3AGreen%2C%20Melissa">Green, Melissa</a>; </li><li><a href="/search/?q=author%3AGrevet%2C%20Eugenio">Grevet, Eugenio</a>; </li><li><a href="/search/?q=author%3AGrigoroiu-Serbanescu%2C%20Maria">Grigoroiu-Serbanescu, Maria</a>; </li><li><a href="/search/?q=author%3AGutierrez%2C%20Blanca">Gutierrez, Blanca</a>; </li><li><a href="/search/?q=author%3AGuzman-Parra%2C%20Jose">Guzman-Parra, Jose</a>; </li><li><a href="/search/?q=author%3AHamshere%2C%20Marian">Hamshere, Marian</a>; </li><li><a href="/search/?q=author%3AHartmann%2C%20Annette">Hartmann, Annette</a>; </li><li><a href="/search/?q=author%3AHauser%2C%20Joanna">Hauser, Joanna</a>; </li><li><a href="/search/?q=author%3AHeilmann-Heimbach%2C%20Stefanie">Heilmann-Heimbach, Stefanie</a>; </li><li><a href="/search/?q=author%3AHoffmann%2C%20Per">Hoffmann, Per</a>; </li><li><a href="/search/?q=author%3AIsing%2C%20Marcus">Ising, Marcus</a>; </li><li><a href="/search/?q=author%3AJones%2C%20Ian">Jones, Ian</a>; </li><li><a href="/search/?q=author%3AJones%2C%20Lisa">Jones, Lisa</a>; </li><li><a href="/search/?q=author%3AJonsson%2C%20Lina">Jonsson, Lina</a>; </li><li><a href="/search/?q=author%3AKahn%2C%20Ren%C3%A9">Kahn, René</a>; </li><li><a href="/search/?q=author%3AKelsoe%2C%20John">Kelsoe, John</a>; </li><li><a href="/search/?q=author%3AKendler%2C%20Kenneth">Kendler, Kenneth</a>; </li><li><a href="/search/?q=author%3AKloiber%2C%20Stefan">Kloiber, Stefan</a>; </li><li><a href="/search/?q=author%3AKoenen%2C%20Karestan">Koenen, Karestan</a>; </li><li><a href="/search/?q=author%3AKogevinas%2C%20Manolis">Kogevinas, Manolis</a>; </li><li><a href="/search/?q=author%3AKrebs%2C%20Marie-Odile">Krebs, Marie-Odile</a>; </li><li><a href="/search/?q=author%3ALand%C3%A9n%2C%20Mikael">Landén, Mikael</a>; </li><li><a href="/search/?q=author%3ALeboyer%2C%20Marion">Leboyer, Marion</a>; </li><li><a href="/search/?q=author%3ALee%2C%20Phil">Lee, Phil</a>; </li><li><a href="/search/?q=author%3ALevinson%2C%20Douglas">Levinson, Douglas</a>; </li><li><a href="/search/?q=author%3ALiao%2C%20Calwing">Liao, Calwing</a>; </li><li><a href="/search/?q=author%3ALissowska%2C%20Jolanta">Lissowska, Jolanta</a>; </li><li><a href="/search/?q=author%3AMayoral%2C%20Fermin">Mayoral, Fermin</a>; </li><li><a href="/search/?q=author%3AMcElroy%2C%20Susan">McElroy, Susan</a>; </li><li><a href="/search/?q=author%3AMcGrath%2C%20Patrick">McGrath, Patrick</a>; </li><li><a href="/search/?q=author%3AMcGuffin%2C%20Peter">McGuffin, Peter</a>; </li><li><a href="/search/?q=author%3AMcQuillin%2C%20Andrew">McQuillin, Andrew</a>; </li><li><a href="/search/?q=author%3AMehta%2C%20Divya">Mehta, Divya</a>; </li><li><a href="/search/?q=author%3AMelle%2C%20Ingrid">Melle, Ingrid</a>; </li><li><a href="/search/?q=author%3AMitchell%2C%20Philip">Mitchell, Philip</a>; </li><li><a href="/search/?q=author%3AMolina%2C%20Esther">Molina, Esther</a>; </li><li><a href="/search/?q=author%3AMorken%2C%20Gunnar">Morken, Gunnar</a>; </li><li><a href="/search/?q=author%3ANievergelt%2C%20Caroline">Nievergelt, Caroline</a>; </li><li><a href="/search/?q=author%3AN%C3%B6then%2C%20Markus">Nöthen, Markus</a>; </li><li><a href="/search/?q=author%3AODonovan%2C%20Michael">ODonovan, Michael</a>; </li><li><a href="/search/?q=author%3AOphoff%2C%20Roel">Ophoff, Roel</a>; </li><li><a href="/search/?q=author%3AOwen%2C%20Michael">Owen, Michael</a>; </li><li><a href="/search/?q=author%3APato%2C%20Carlos">Pato, Carlos</a>; </li><li><a href="/search/?q=author%3APato%2C%20Michele">Pato, Michele</a>; </li><li><a href="/search/?q=author%3APenninx%2C%20Brenda">Penninx, Brenda</a>; </li><li><a href="/search/?q=author%3APotash%2C%20James">Potash, James</a>; </li><li><a href="/search/?q=author%3APower%2C%20Robert">Power, Robert</a>; </li><li><a href="/search/?q=author%3APreisig%2C%20Martin">Preisig, Martin</a>; </li><li><a href="/search/?q=author%3AQuested%2C%20Digby">Quested, Digby</a>; </li><li><a href="/search/?q=author%3ARamos-Quiroga%2C%20Josep">Ramos-Quiroga, Josep</a>; </li><li><a href="/search/?q=author%3AReif%2C%20Andreas">Reif, Andreas</a>; </li><li><a href="/search/?q=author%3ARibas%C3%A9s%2C%20Marta">Ribasés, Marta</a>; </li><li><a href="/search/?q=author%3ARicharte%2C%20Vanesa">Richarte, Vanesa</a>; </li><li><a href="/search/?q=author%3ARietschel%2C%20Marcella">Rietschel, Marcella</a>; </li><li><a href="/search/?q=author%3ARivera%2C%20Margarita">Rivera, Margarita</a>; </li><li><a href="/search/?q=author%3ARoberts%2C%20Andrea">Roberts, Andrea</a>; </li><li><a href="/search/?q=author%3ARoberts%2C%20Gloria">Roberts, Gloria</a>; </li><li><a href="/search/?q=author%3ARouleau%2C%20Guy">Rouleau, Guy</a>; </li><li><a href="/search/?q=author%3ARovaris%2C%20Diego">Rovaris, Diego</a>; </li><li><a href="/search/?q=author%3ASanders%2C%20Alan">Sanders, Alan</a>; </li><li><a href="/search/?q=author%3ASchofield%2C%20Peter">Schofield, Peter</a>; </li><li><a href="/search/?q=author%3ASchulze%2C%20Thomas">Schulze, Thomas</a>; </li><li><a href="/search/?q=author%3AScott%2C%20Laura">Scott, Laura</a>; </li><li><a href="/search/?q=author%3ASerretti%2C%20Alessandro">Serretti, Alessandro</a>; </li><li><a href="/search/?q=author%3AShi%2C%20Jianxin">Shi, Jianxin</a>; </li><li><a href="/search/?q=author%3ASirignano%2C%20Lea">Sirignano, Lea</a>; </li><li><a href="/search/?q=author%3ASklar%2C%20Pamela">Sklar, Pamela</a>; </li><li><a href="/search/?q=author%3ASmeland%2C%20Olav">Smeland, Olav</a>; </li><li><a href="/search/?q=author%3ASmoller%2C%20Jordan">Smoller, Jordan</a>; </li><li><a href="/search/?q=author%3ASonuga-Barke%2C%20Edmund">Sonuga-Barke, Edmund</a>; </li><li><a href="/search/?q=author%3ATrzaskowski%2C%20Maciej">Trzaskowski, Maciej</a>; </li><li><a href="/search/?q=author%3ATsuang%2C%20Ming">Tsuang, Ming</a>; </li><li><a href="/search/?q=author%3ATurecki%2C%20Gustavo">Turecki, Gustavo</a>; </li><li><a href="/search/?q=author%3AVilar-Rib%C3%B3%2C%20Laura">Vilar-Ribó, Laura</a>; </li><li><a href="/search/?q=author%3AVincent%2C%20John">Vincent, John</a>; </li><li><a href="/search/?q=author%3AV%C3%B6lzke%2C%20Henry">Völzke, Henry</a>; </li><li><a href="/search/?q=author%3AWalters%2C%20James">Walters, James</a>; </li><li><a href="/search/?q=author%3AWeickert%2C%20Cynthia">Weickert, Cynthia</a>; </li><li><a href="/search/?q=author%3AWeickert%2C%20Thomas">Weickert, Thomas</a>; </li><li><a href="/search/?q=author%3AWeissman%2C%20Myrna">Weissman, Myrna</a>; </li><li><a href="/search/?q=author%3AWilliams%2C%20Leanne">Williams, Leanne</a>; </li><li><a href="/search/?q=author%3AWray%2C%20Naomi">Wray, Naomi</a>; </li><li><a href="/search/?q=author%3AZai%2C%20Clement">Zai, Clement</a>; </li><li><a href="/search/?q=author%3AAgerbo%2C%20Esben">Agerbo, Esben</a>; </li><li><a href="/search/?q=author%3AB%C3%B8rglum%2C%20Anders">Børglum, Anders</a>; </li><li><a href="/search/?q=author%3ABreen%2C%20Gerome">Breen, Gerome</a>; </li><li><a href="/search/?q=author%3ADemontis%2C%20Ditte">Demontis, Ditte</a>; </li><li><a href="/search/?q=author%3AErlangsen%2C%20Annette">Erlangsen, Annette</a>; </li><li><a href="/search/?q=author%3AGelernter%2C%20Joel">Gelernter, Joel</a>; </li><li><a href="/search/?q=author%3AGlatt%2C%20Stephen">Glatt, Stephen</a>; </li><li><a href="/search/?q=author%3AHougaard%2C%20David">Hougaard, David</a>; </li><li><a href="/search/?q=author%3AHwu%2C%20Hai-Gwo">Hwu, Hai-Gwo</a>; </li><li><a href="/search/?q=author%3AKuo%2C%20Po-Hsiu">Kuo, Po-Hsiu</a>; </li><li><a href="/search/?q=author%3ALewis%2C%20Cathryn">Lewis, Cathryn</a>; </li><li><a href="/search/?q=author%3ALi%2C%20Qingqin">Li, Qingqin</a>; </li><li><a href="/search/?q=author%3ALiu%2C%20Chih-Min">Liu, Chih-Min</a>; </li><li><a href="/search/?q=author%3AMartin%2C%20Nicholas">Martin, Nicholas</a>; </li><li><a href="/search/?q=author%3AMcIntosh%2C%20Andrew">McIntosh, Andrew</a>; </li><li><a href="/search/?q=author%3AMedland%2C%20Sarah">Medland, Sarah</a>; </li><li><a href="/search/?q=author%3AMors%2C%20Ole">Mors, Ole</a>; </li><li><a href="/search/?q=author%3ANordentoft%2C%20Merete">Nordentoft, Merete</a>; </li><li><a href="/search/?q=author%3AOlsen%2C%20Catherine">Olsen, Catherine</a>; </li><li><a href="/search/?q=author%3APorteous%2C%20David">Porteous, David</a>; </li><li><a href="/search/?q=author%3ASmith%2C%20Daniel">Smith, Daniel</a>; </li><li><a href="/search/?q=author%3AStahl%2C%20Eli">Stahl, Eli</a>; </li><li><a href="/search/?q=author%3AStein%2C%20Murray">Stein, Murray</a>; </li><li><a href="/search/?q=author%3AWasserman%2C%20Danuta">Wasserman, Danuta</a>; </li><li><a href="/search/?q=author%3AWerge%2C%20Thomas">Werge, Thomas</a>; </li><li><a href="/search/?q=author%3AWhiteman%2C%20David">Whiteman, David</a>; </li><li><a href="/search/?q=author%3AWillour%2C%20Virginia">Willour, Virginia</a>; </li><li><a href="/search/?q=author%3ACoon%2C%20Hilary">Coon, Hilary</a>; </li><li><a href="/search/?q=author%3ABeckham%2C%20Jean">Beckham, Jean</a>; </li><li><a href="/search/?q=author%3AKimbrel%2C%20Nathan">Kimbrel, Nathan</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3ARuderfer%2C%20Douglas">Ruderfer, Douglas</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucsd_postprints">UC San Diego Previously Published Works</a> (2023)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup">OBJECTIVE: Suicidal behavior is heritable and is a major cause of death worldwide. Two large-scale genome-wide association studies (GWASs) recently discovered and cross-validated genome-wide significant (GWS) loci for suicide attempt (SA). The present study leveraged the genetic cohorts from both studies to conduct the largest GWAS meta-analysis of SA to date. Multi-ancestry and admixture-specific meta-analyses were conducted within groups of significant African, East Asian, and European ancestry admixtures. METHODS: This study comprised 22 cohorts, including 43,871 SA cases and 915,025 ancestry-matched controls. Analytical methods across multi-ancestry and individual ancestry admixtures included inverse variance-weighted fixed-effects meta-analyses, followed by gene, gene-set, tissue-set, and drug-target enrichment, as well as summary-data-based Mendelian randomization with brain expression quantitative trait loci data, phenome-wide genetic correlation, and genetic causal proportion analyses. RESULTS: Multi-ancestry and European ancestry admixture GWAS meta-analyses identified 12 risk loci at p values <5×10-8. These loci were mostly intergenic and implicated DRD2, SLC6A9, FURIN, NLGN1, SOX5, PDE4B, and CACNG2. The multi-ancestry SNP-based heritability estimate of SA was 5.7% on the liability scale (SE=0.003, p=5.7×10-80). Significant brain tissue gene expression and drug set enrichment were observed. There was shared genetic variation of SA with attention deficit hyperactivity disorder, smoking, and risk tolerance after conditioning SA on both major depressive disorder and posttraumatic stress disorder. Genetic causal proportion analyses implicated shared genetic risk for specific health factors. CONCLUSIONS: This multi-ancestry analysis of suicide attempt identified several loci contributing to risk and establishes significant shared genetic covariation with clinical phenotypes. These findings provide insight into genetic factors associated with suicide attempt across ancestry admixture populations, in veteran and civilian populations, and in attempt versus death.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/3q8267gj"><img src="/cms-assets/bc6df6b0c58f92cc33a3970dabc84d53887fa911c3d210be593ffca25f88f852" alt="Cover page: GWAS Meta-Analysis of Suicide Attempt: Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors."/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/1rb9b4d6"><div class="c-clientmarkup">Genetic Overlap Between Alzheimer’s Disease and Bipolar Disorder Implicates the MARK2 and VAC14 Genes</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3ADrange%2C%20Ole%20Kristian">Drange, Ole Kristian</a>; </li><li><a href="/search/?q=author%3ASmeland%2C%20Olav%20Bjerkehagen">Smeland, Olav Bjerkehagen</a>; </li><li><a href="/search/?q=author%3AShadrin%2C%20Alexey%20A">Shadrin, Alexey A</a>; </li><li><a href="/search/?q=author%3AFinseth%2C%20Per%20Ivar">Finseth, Per Ivar</a>; </li><li><a href="/search/?q=author%3AWitoelar%2C%20Aree">Witoelar, Aree</a>; </li><li><a href="/search/?q=author%3AFrei%2C%20Oleksandr">Frei, Oleksandr</a>; </li><li><a href="/search/?q=author%3AGroup%2C%20Psychiatric%20Genomics%20Consortium%20Bipolar%20Disorder%20Working">Group, Psychiatric Genomics Consortium Bipolar Disorder Working</a>; </li><li><a href="/search/?q=author%3AWang%2C%20Yunpeng">Wang, Yunpeng</a>; </li><li><a href="/search/?q=author%3AHassani%2C%20Sahar">Hassani, Sahar</a>; </li><li><a href="/search/?q=author%3ADjurovic%2C%20Srdjan">Djurovic, Srdjan</a>; </li><li><a href="/search/?q=author%3ADale%2C%20Anders%20M">Dale, Anders M</a>; </li><li><a href="/search/?q=author%3AAndreassen%2C%20Ole%20A">Andreassen, Ole A</a>; </li><li><a href="/search/?q=author%3AStahl%2C%20Eli%20A">Stahl, Eli A</a>; </li><li><a href="/search/?q=author%3ABreen%2C%20Gerome">Breen, Gerome</a>; </li><li><a href="/search/?q=author%3AForstner%2C%20Andreas%20J">Forstner, Andreas J</a>; </li><li><a href="/search/?q=author%3AMcQuillin%2C%20Andrew">McQuillin, Andrew</a>; </li><li><a href="/search/?q=author%3ARipke%2C%20Stephan">Ripke, Stephan</a>; </li><li><a href="/search/?q=author%3ATrubetskoy%2C%20Vassily">Trubetskoy, Vassily</a>; </li><li><a href="/search/?q=author%3AMattheisen%2C%20Manuel">Mattheisen, Manuel</a>; </li><li><a href="/search/?q=author%3AWang%2C%20Yunpeng">Wang, Yunpeng</a>; </li><li><a href="/search/?q=author%3AColeman%2C%20Jonathan%20RI">Coleman, Jonathan RI</a>; </li><li><a href="/search/?q=author%3AGaspar%2C%20He%C3%ACle%C3%ACna%20A">Gaspar, Heìleìna A</a>; </li><li><a href="/search/?q=author%3Ade%20Leeuw%2C%20Christiaan%20A">de Leeuw, Christiaan A</a>; </li><li><a href="/search/?q=author%3ASteinberg%2C%20Stacy">Steinberg, Stacy</a>; </li><li><a href="/search/?q=author%3APavlides%2C%20Jennifer%20M%20Whitehead">Pavlides, Jennifer M Whitehead</a>; </li><li><a href="/search/?q=author%3ATrzaskowski%2C%20Maciej">Trzaskowski, Maciej</a>; </li><li><a href="/search/?q=author%3APers%2C%20Tune%20H">Pers, Tune H</a>; </li><li><a href="/search/?q=author%3AHolmans%2C%20Peter%20A">Holmans, Peter A</a>; </li><li><a href="/search/?q=author%3AAbbott%2C%20Liam">Abbott, Liam</a>; </li><li><a href="/search/?q=author%3AAgerbo%2C%20Esben">Agerbo, Esben</a>; </li><li><a href="/search/?q=author%3AAkil%2C%20Huda">Akil, Huda</a>; </li><li><a href="/search/?q=author%3AAlbani%2C%20Diego">Albani, Diego</a>; </li><li><a href="/search/?q=author%3AAlliey-Rodriguez%2C%20Ney">Alliey-Rodriguez, Ney</a>; </li><li><a href="/search/?q=author%3AAls%2C%20Thomas%20D">Als, Thomas D</a>; </li><li><a href="/search/?q=author%3AAnjorin%2C%20Adebayo">Anjorin, Adebayo</a>; </li><li><a href="/search/?q=author%3AAntilla%2C%20Verneri">Antilla, Verneri</a>; </li><li><a href="/search/?q=author%3AAwasthi%2C%20Swapnil">Awasthi, Swapnil</a>; </li><li><a href="/search/?q=author%3ABadner%2C%20Judith%20A">Badner, Judith A</a>; </li><li><a href="/search/?q=author%3AB%C3%A6kvad-Hansen%2C%20Marie">Bækvad-Hansen, Marie</a>; </li><li><a href="/search/?q=author%3ABarchas%2C%20Jack%20D">Barchas, Jack D</a>; </li><li><a href="/search/?q=author%3ABass%2C%20Nicholas">Bass, Nicholas</a>; </li><li><a href="/search/?q=author%3ABauer%2C%20Michael">Bauer, Michael</a>; </li><li><a href="/search/?q=author%3ABelliveau%2C%20Richard">Belliveau, Richard</a>; </li><li><a href="/search/?q=author%3ABergen%2C%20Sarah%20E">Bergen, Sarah E</a>; </li><li><a href="/search/?q=author%3APedersen%2C%20Carsten%20B%C3%B8cker">Pedersen, Carsten Bøcker</a>; </li><li><a href="/search/?q=author%3AB%C3%B8en%2C%20Erlend">Bøen, Erlend</a>; </li><li><a href="/search/?q=author%3ABoks%2C%20Marco">Boks, Marco</a>; </li><li><a href="/search/?q=author%3ABoocock%2C%20James">Boocock, James</a>; </li><li><a href="/search/?q=author%3ABudde%2C%20Monika">Budde, Monika</a>; </li><li><a href="/search/?q=author%3ABunney%2C%20William">Bunney, William</a>; </li><li><a href="/search/?q=author%3ABurmeister%2C%20Margit">Burmeister, Margit</a>; </li><li><a href="/search/?q=author%3ABybjerg-Grauholm%2C%20Jonas">Bybjerg-Grauholm, Jonas</a>; </li><li><a href="/search/?q=author%3AByerley%2C%20William">Byerley, William</a>; </li><li><a href="/search/?q=author%3ACasas%2C%20Miquel">Casas, Miquel</a>; </li><li><a href="/search/?q=author%3ACerrato%2C%20Felecia">Cerrato, Felecia</a>; </li><li><a href="/search/?q=author%3ACervantes%2C%20Pablo">Cervantes, Pablo</a>; </li><li><a href="/search/?q=author%3AChambert%2C%20Kimberly">Chambert, Kimberly</a>; </li><li><a href="/search/?q=author%3ACharney%2C%20Alexander%20W">Charney, Alexander W</a>; </li><li><a href="/search/?q=author%3AChen%2C%20Danfeng">Chen, Danfeng</a>; </li><li><a href="/search/?q=author%3AChurchhouse%2C%20Claire">Churchhouse, Claire</a>; </li><li><a href="/search/?q=author%3AClarke%2C%20Toni-Kim">Clarke, Toni-Kim</a>; </li><li><a href="/search/?q=author%3ACoryell%2C%20William">Coryell, William</a>; </li><li><a href="/search/?q=author%3ACraig%2C%20David%20W">Craig, David W</a>; </li><li><a href="/search/?q=author%3ACruceanu%2C%20Cristiana">Cruceanu, Cristiana</a>; </li><li><a href="/search/?q=author%3ACurtis%2C%20David">Curtis, David</a>; </li><li><a href="/search/?q=author%3ACzerski%2C%20Piotr%20M">Czerski, Piotr M</a>; </li><li><a href="/search/?q=author%3ADale%2C%20Anders%20M">Dale, Anders M</a>; </li><li><a href="/search/?q=author%3Ade%20Jong%2C%20Simone">de Jong, Simone</a>; </li><li><a href="/search/?q=author%3ADegenhardt%2C%20Franziska">Degenhardt, Franziska</a>; </li><li><a href="/search/?q=author%3ADel-Favero%2C%20Jurgen">Del-Favero, Jurgen</a>; </li><li><a href="/search/?q=author%3ADePaulo%2C%20J%20Raymond">DePaulo, J Raymond</a>; </li><li><a href="/search/?q=author%3ADjurovic%2C%20Srdjan">Djurovic, Srdjan</a>; </li><li><a href="/search/?q=author%3ADobbyn%2C%20Amanda%20L">Dobbyn, Amanda L</a>; </li><li><a href="/search/?q=author%3ADumont%2C%20Ashley">Dumont, Ashley</a>; </li><li><a href="/search/?q=author%3AElvs%C3%A5shagen%2C%20Torbj%C3%B8rn">Elvsåshagen, Torbjørn</a>; </li><li><a href="/search/?q=author%3AEscott-Price%2C%20Valentina">Escott-Price, Valentina</a>; </li><li><a href="/search/?q=author%3AFan%2C%20Chun%20Chieh">Fan, Chun Chieh</a>; </li><li><a href="/search/?q=author%3AFischer%2C%20Sascha%20B">Fischer, Sascha B</a>; </li><li><a href="/search/?q=author%3AFlickinger%2C%20Matthew">Flickinger, Matthew</a>; </li><li><a href="/search/?q=author%3AForoud%2C%20Tatiana%20M">Foroud, Tatiana M</a>; </li><li><a href="/search/?q=author%3AForty%2C%20Liz">Forty, Liz</a>; </li><li><a href="/search/?q=author%3AFrank%2C%20Josef">Frank, Josef</a>; </li><li><a href="/search/?q=author%3AFraser%2C%20Christine">Fraser, Christine</a>; </li><li><a href="/search/?q=author%3AFreimer%2C%20Nelson%20B">Freimer, Nelson B</a>; </li><li><a href="/search/?q=author%3AFrise%C3%ACn%2C%20Louise">Friseìn, Louise</a>; </li><li><a href="/search/?q=author%3AGade%2C%20Katrin">Gade, Katrin</a>; </li><li><a href="/search/?q=author%3AGage%2C%20Diane">Gage, Diane</a>; </li><li><a href="/search/?q=author%3AGarnham%2C%20Julie">Garnham, Julie</a>; </li><li><a href="/search/?q=author%3AGiambartolomei%2C%20Claudia">Giambartolomei, Claudia</a>; </li><li><a href="/search/?q=author%3APedersen%2C%20Marianne%20Gi%C3%B8rtz">Pedersen, Marianne Giørtz</a>; </li><li><a href="/search/?q=author%3AGoldstein%2C%20Jaqueline">Goldstein, Jaqueline</a>; </li><li><a href="/search/?q=author%3AGordon%2C%20Scott%20D">Gordon, Scott D</a>; </li><li><a href="/search/?q=author%3AGordon-Smith%2C%20Katherine">Gordon-Smith, Katherine</a>; </li><li><a href="/search/?q=author%3AGreen%2C%20Elaine%20K">Green, Elaine K</a>; </li><li><a href="/search/?q=author%3AGreen%2C%20Melissa%20J">Green, Melissa J</a>; </li><li><a href="/search/?q=author%3AGreenwood%2C%20Tiffany%20A">Greenwood, Tiffany A</a>; </li><li><a href="/search/?q=author%3AGrove%2C%20Jakob">Grove, Jakob</a>; </li><li><a href="/search/?q=author%3AGuan%2C%20Weihua">Guan, Weihua</a>; </li><li><a href="/search/?q=author%3AParra%2C%20Jose%C3%AC%20Guzman">Parra, Joseì Guzman</a>; </li><li><a href="/search/?q=author%3AHamshere%2C%20Marian%20L">Hamshere, Marian L</a>; </li><li><a href="/search/?q=author%3AHautzinger%2C%20Martin">Hautzinger, Martin</a>; </li><li><a href="/search/?q=author%3AHeilbronner%2C%20Urs">Heilbronner, Urs</a>; </li><li><a href="/search/?q=author%3AHerms%2C%20Stefan">Herms, Stefan</a>; </li><li><a href="/search/?q=author%3AHipolito%2C%20Maria">Hipolito, Maria</a>; </li><li><a href="/search/?q=author%3AHoffmann%2C%20Per">Hoffmann, Per</a>; </li><li><a href="/search/?q=author%3AHolland%2C%20Dominic">Holland, Dominic</a>; </li><li><a href="/search/?q=author%3AHuckins%2C%20Laura">Huckins, Laura</a>; </li><li><a href="/search/?q=author%3AJamain%2C%20Ste%C3%ACphane">Jamain, Steìphane</a>; </li><li><a href="/search/?q=author%3AJohnson%2C%20Jessica%20S">Johnson, Jessica S</a>; </li><li><a href="/search/?q=author%3AJure%C3%ACus%2C%20Anders">Jureìus, Anders</a>; </li><li><a href="/search/?q=author%3AKandaswamy%2C%20Radhika">Kandaswamy, Radhika</a>; </li><li><a href="/search/?q=author%3AKarlsson%2C%20Robert">Karlsson, Robert</a>; </li><li><a href="/search/?q=author%3AKennedy%2C%20James%20L">Kennedy, James L</a>; </li><li><a href="/search/?q=author%3AKittel-Schneider%2C%20Sarah">Kittel-Schneider, Sarah</a>; </li><li><a href="/search/?q=author%3AKnott%2C%20Sarah%20V">Knott, Sarah V</a>; </li><li><a href="/search/?q=author%3AKnowles%2C%20James%20A">Knowles, James A</a>; </li><li><a href="/search/?q=author%3AKogevinas%2C%20Manolis">Kogevinas, Manolis</a>; </li><li><a href="/search/?q=author%3AKoller%2C%20Anna%20C">Koller, Anna C</a>; </li><li><a href="/search/?q=author%3AKupka%2C%20Ralph">Kupka, Ralph</a>; </li><li><a href="/search/?q=author%3ALavebratt%2C%20Catharina">Lavebratt, Catharina</a>; </li><li><a href="/search/?q=author%3ALawrence%2C%20Jacob">Lawrence, Jacob</a>; </li><li><a href="/search/?q=author%3ALawson%2C%20William%20B">Lawson, William B</a>; </li><li><a href="/search/?q=author%3ALeber%2C%20Markus">Leber, Markus</a>; </li><li><a href="/search/?q=author%3ALee%2C%20Phil%20H">Lee, Phil H</a>; </li><li><a href="/search/?q=author%3ALevy%2C%20Shawn%20E">Levy, Shawn E</a>; </li><li><a href="/search/?q=author%3ALi%2C%20Jun%20Z">Li, Jun Z</a>; </li><li><a href="/search/?q=author%3ALiu%2C%20Chunyu">Liu, Chunyu</a>; </li><li><a href="/search/?q=author%3ALucae%2C%20Susanne">Lucae, Susanne</a>; </li><li><a href="/search/?q=author%3AMaaser%2C%20Anna">Maaser, Anna</a>; </li><li><a href="/search/?q=author%3AMacIntyre%2C%20Donald%20J">MacIntyre, Donald J</a>; </li><li><a href="/search/?q=author%3AMahon%2C%20Pamela%20B">Mahon, Pamela B</a>; </li><li><a href="/search/?q=author%3AMaier%2C%20Wolfgang">Maier, Wolfgang</a>; </li><li><a href="/search/?q=author%3AMartinsson%2C%20Lina">Martinsson, Lina</a>; </li><li><a href="/search/?q=author%3AMcCarroll%2C%20Steve">McCarroll, Steve</a>; </li><li><a href="/search/?q=author%3AMcGuffin%2C%20Peter">McGuffin, Peter</a>; </li><li><a href="/search/?q=author%3AMcInnis%2C%20Melvin%20G">McInnis, Melvin G</a>; </li><li><a href="/search/?q=author%3AMcKay%2C%20James%20D">McKay, James D</a>; </li><li><a href="/search/?q=author%3AMedeiros%2C%20Helena">Medeiros, Helena</a>; </li><li><a href="/search/?q=author%3AMedland%2C%20Sarah%20E">Medland, Sarah E</a>; </li><li><a href="/search/?q=author%3AMeng%2C%20Fan">Meng, Fan</a>; </li><li><a href="/search/?q=author%3AMilani%2C%20Lili">Milani, Lili</a>; </li><li><a href="/search/?q=author%3AMontgomery%2C%20Grant%20W">Montgomery, Grant W</a>; </li><li><a href="/search/?q=author%3AMorris%2C%20Derek%20W">Morris, Derek W</a>; </li><li><a href="/search/?q=author%3AM%C3%BChleisen%2C%20Thomas%20W">Mühleisen, Thomas W</a>; </li><li><a href="/search/?q=author%3AMullins%2C%20Niamh">Mullins, Niamh</a>; </li><li><a href="/search/?q=author%3ANguyen%2C%20Hoang">Nguyen, Hoang</a>; </li><li><a href="/search/?q=author%3ANievergelt%2C%20Caroline%20M">Nievergelt, Caroline M</a>; </li><li><a href="/search/?q=author%3AAdolfsson%2C%20Annelie%20Nordin">Adolfsson, Annelie Nordin</a>; </li><li><a href="/search/?q=author%3ANwulia%2C%20Evaristus%20A">Nwulia, Evaristus A</a>; </li><li><a href="/search/?q=author%3AO%E2%80%99Donovan%2C%20Claire">O’Donovan, Claire</a>; </li><li><a href="/search/?q=author%3ALoohuis%2C%20Loes%20M%20Olde">Loohuis, Loes M Olde</a>; </li><li><a href="/search/?q=author%3AOri%2C%20Anil%20PS">Ori, Anil PS</a>; </li><li><a href="/search/?q=author%3AOruc%2C%20Lilijana">Oruc, Lilijana</a>; </li><li><a href="/search/?q=author%3A%C3%96sby%2C%20Urban">Ösby, Urban</a>; </li><li><a href="/search/?q=author%3APerlis%2C%20Roy%20H">Perlis, Roy H</a>; </li><li><a href="/search/?q=author%3APerry%2C%20Amy">Perry, Amy</a>; </li><li><a href="/search/?q=author%3APfennig%2C%20Andrea">Pfennig, Andrea</a>; </li><li><a href="/search/?q=author%3APotash%2C%20James%20B">Potash, James B</a>; </li><li><a href="/search/?q=author%3APurcell%2C%20Shaun%20M">Purcell, Shaun M</a>; </li><li><a href="/search/?q=author%3ARegeer%2C%20Eline%20J">Regeer, Eline J</a>; </li><li><a href="/search/?q=author%3AReif%2C%20Andreas">Reif, Andreas</a>; </li><li><a href="/search/?q=author%3AReinbold%2C%20Ce%C3%ACline%20S">Reinbold, Ceìline S</a>; </li><li><a href="/search/?q=author%3ARice%2C%20John%20P">Rice, John P</a>; </li><li><a href="/search/?q=author%3ARivas%2C%20Fabio">Rivas, Fabio</a>; </li><li><a href="/search/?q=author%3ARivera%2C%20Margarita">Rivera, Margarita</a>; </li><li><a href="/search/?q=author%3ARoussos%2C%20Panos">Roussos, Panos</a>; </li><li><a href="/search/?q=author%3ARuderfer%2C%20Douglas%20M">Ruderfer, Douglas M</a>; </li><li><a href="/search/?q=author%3ARyu%2C%20Euijung">Ryu, Euijung</a>; </li><li><a href="/search/?q=author%3ASa%C3%ACnchez-Mora%2C%20Cristina">Saìnchez-Mora, Cristina</a>; </li><li><a href="/search/?q=author%3ASchatzberg%2C%20Alan%20F">Schatzberg, Alan F</a>; </li><li><a href="/search/?q=author%3AScheftner%2C%20William%20A">Scheftner, William A</a>; </li><li><a href="/search/?q=author%3ASchork%2C%20Nicholas%20J">Schork, Nicholas J</a>; </li><li><a href="/search/?q=author%3AWeickert%2C%20Cynthia%20Shannon">Weickert, Cynthia Shannon</a>; </li><li><a href="/search/?q=author%3AShehktman%2C%20Tatyana">Shehktman, Tatyana</a>; </li><li><a href="/search/?q=author%3AShilling%2C%20Paul%20D">Shilling, Paul D</a>; </li><li><a href="/search/?q=author%3ASigurdsson%2C%20Engilbert">Sigurdsson, Engilbert</a>; </li><li><a href="/search/?q=author%3ASlaney%2C%20Claire">Slaney, Claire</a>; </li><li><a href="/search/?q=author%3ASmeland%2C%20Olav%20B">Smeland, Olav B</a>; </li><li><a href="/search/?q=author%3ASobell%2C%20Janet%20L">Sobell, Janet L</a>; </li><li><a href="/search/?q=author%3AHansen%2C%20Christine%20S%C3%B8holm">Hansen, Christine Søholm</a>; </li><li><a href="/search/?q=author%3ASpijker%2C%20Anne%20T">Spijker, Anne T</a>; </li><li><a href="/search/?q=author%3ASt%20Clair%2C%20David">St Clair, David</a>; </li><li><a href="/search/?q=author%3ASteffens%2C%20Michael">Steffens, Michael</a>; </li><li><a href="/search/?q=author%3AStrauss%2C%20John%20S">Strauss, John S</a>; </li><li><a href="/search/?q=author%3AStreit%2C%20Fabian">Streit, Fabian</a>; </li><li><a href="/search/?q=author%3AStrohmaier%2C%20Jana">Strohmaier, Jana</a>; </li><li><a href="/search/?q=author%3ASzelinger%2C%20Szabolcs">Szelinger, Szabolcs</a>; </li><li><a href="/search/?q=author%3AThompson%2C%20Robert%20C">Thompson, Robert C</a>; </li><li><a href="/search/?q=author%3AThorgeirsson%2C%20Thorgeir%20E">Thorgeirsson, Thorgeir E</a>; </li><li><a href="/search/?q=author%3ATreutlein%2C%20Jens">Treutlein, Jens</a>; </li><li><a href="/search/?q=author%3AVedder%2C%20Helmut">Vedder, Helmut</a>; </li><li><a href="/search/?q=author%3AWang%2C%20Weiqing">Wang, Weiqing</a>; </li><li><a href="/search/?q=author%3AWatson%2C%20Stanley%20J">Watson, Stanley J</a>; </li><li><a href="/search/?q=author%3AWeickert%2C%20Thomas%20W">Weickert, Thomas W</a>; </li><li><a href="/search/?q=author%3AWitt%2C%20Stephanie%20H">Witt, Stephanie H</a>; </li><li><a href="/search/?q=author%3AXi%2C%20Simon">Xi, Simon</a>; </li><li><a href="/search/?q=author%3AXu%2C%20Wei">Xu, Wei</a>; </li><li><a href="/search/?q=author%3AYoung%2C%20Allan%20H">Young, Allan H</a>; </li><li><a href="/search/?q=author%3AZandi%2C%20Peter">Zandi, Peter</a>; </li><li><a href="/search/?q=author%3AZhang%2C%20Peng">Zhang, Peng</a>; </li><li><a href="/search/?q=author%3AZollner%2C%20Sebastian">Zollner, Sebastian</a>; </li><li><a href="/search/?q=author%3AAdolfsson%2C%20Rolf">Adolfsson, Rolf</a>; </li><li><a href="/search/?q=author%3AAgartz%2C%20Ingrid">Agartz, Ingrid</a>; </li><li><a href="/search/?q=author%3AAlda%2C%20Martin">Alda, Martin</a>; </li><li><a href="/search/?q=author%3ABacklund%2C%20Lena">Backlund, Lena</a>; </li><li><a href="/search/?q=author%3ABaune%2C%20Bernhard%20T">Baune, Bernhard T</a>; </li><li><a href="/search/?q=author%3ABellivier%2C%20Frank">Bellivier, Frank</a>; </li><li><a href="/search/?q=author%3ABerrettini%2C%20Wade%20H">Berrettini, Wade H</a>; </li><li><a href="/search/?q=author%3ABiernacka%2C%20Joanna%20M">Biernacka, Joanna M</a>; </li><li><a href="/search/?q=author%3ABlackwood%2C%20Douglas%20HR">Blackwood, Douglas HR</a>; </li><li><a href="/search/?q=author%3ABoehnke%2C%20Michael">Boehnke, Michael</a>; </li><li><a href="/search/?q=author%3AB%C3%B8rglum%2C%20Anders%20D">Børglum, Anders D</a>; </li><li><a href="/search/?q=author%3ACorvin%2C%20Aiden">Corvin, Aiden</a>; </li><li><a href="/search/?q=author%3ACraddock%2C%20Nicholas">Craddock, Nicholas</a>; </li><li><a href="/search/?q=author%3ADaly%2C%20Mark%20J">Daly, Mark J</a>; </li><li><a href="/search/?q=author%3ADannlowski%2C%20Udo">Dannlowski, Udo</a>; </li><li><a href="/search/?q=author%3AEsko%2C%20To%C3%9Enu">Esko, ToÞnu</a>; </li><li><a href="/search/?q=author%3AEtain%2C%20Bruno">Etain, Bruno</a>; </li><li><a href="/search/?q=author%3AFrye%2C%20Mark">Frye, Mark</a>; </li><li><a href="/search/?q=author%3AFullerton%2C%20Janice%20M">Fullerton, Janice M</a>; </li><li><a href="/search/?q=author%3AGershon%2C%20Elliot%20S">Gershon, Elliot S</a>; </li><li><a href="/search/?q=author%3AGill%2C%20Michael">Gill, Michael</a>; </li><li><a href="/search/?q=author%3AGoes%2C%20Fernando">Goes, Fernando</a>; </li><li><a href="/search/?q=author%3AGrigoroiu-Serbanescu%2C%20Maria">Grigoroiu-Serbanescu, Maria</a>; </li><li><a href="/search/?q=author%3AHauser%2C%20Joanna">Hauser, Joanna</a>; </li><li><a href="/search/?q=author%3AHougaard%2C%20David%20M">Hougaard, David M</a>; </li><li><a href="/search/?q=author%3AHultman%2C%20Christina%20M">Hultman, Christina M</a>; </li><li><a href="/search/?q=author%3AJones%2C%20Ian">Jones, Ian</a>; </li><li><a href="/search/?q=author%3AJones%2C%20Lisa%20A">Jones, Lisa A</a>; </li><li><a href="/search/?q=author%3AKahn%2C%20Rene%C3%AC%20S">Kahn, Reneì S</a>; </li><li><a href="/search/?q=author%3AKirov%2C%20George">Kirov, George</a>; </li><li><a href="/search/?q=author%3ALande%C3%ACn%2C%20Mikael">Landeìn, Mikael</a>; </li><li><a href="/search/?q=author%3ALeboyer%2C%20Marion">Leboyer, Marion</a>; </li><li><a href="/search/?q=author%3ALewis%2C%20Cathryn%20M">Lewis, Cathryn M</a>; </li><li><a href="/search/?q=author%3ALi%2C%20Qingqin%20S">Li, Qingqin S</a>; </li><li><a href="/search/?q=author%3ALissowska%2C%20Jolanta">Lissowska, Jolanta</a>; </li><li><a href="/search/?q=author%3AMartin%2C%20Nicholas%20G">Martin, Nicholas G</a>; </li><li><a href="/search/?q=author%3AMayoral%2C%20Fermin">Mayoral, Fermin</a>; </li><li><a href="/search/?q=author%3AMcElroy%2C%20Susan%20L">McElroy, Susan L</a>; </li><li><a href="/search/?q=author%3AMcIntosh%2C%20Andrew%20M">McIntosh, Andrew M</a>; </li><li><a href="/search/?q=author%3AMcMahon%2C%20Francis%20J">McMahon, Francis J</a>; </li><li><a href="/search/?q=author%3AMelle%2C%20Ingrid">Melle, Ingrid</a>; </li><li><a href="/search/?q=author%3AMetspalu%2C%20Andres">Metspalu, Andres</a>; </li><li><a href="/search/?q=author%3AMitchell%2C%20Philip%20B">Mitchell, Philip B</a>; </li><li><a href="/search/?q=author%3AMorken%2C%20Gunnar">Morken, Gunnar</a>; </li><li><a href="/search/?q=author%3AMors%2C%20Ole">Mors, Ole</a>; </li><li><a href="/search/?q=author%3AMortensen%2C%20Preben%20Bo">Mortensen, Preben Bo</a>; </li><li><a href="/search/?q=author%3AM%C3%BCller-Myhsok%2C%20Bertram">Müller-Myhsok, Bertram</a>; </li><li><a href="/search/?q=author%3AMyers%2C%20Richard%20M">Myers, Richard M</a>; </li><li><a href="/search/?q=author%3ANeale%2C%20Benjamin%20M">Neale, Benjamin M</a>; </li><li><a href="/search/?q=author%3ANimgaonkar%2C%20Vishwajit">Nimgaonkar, Vishwajit</a>; </li><li><a href="/search/?q=author%3ANordentoft%2C%20Merete">Nordentoft, Merete</a>; </li><li><a href="/search/?q=author%3AN%C3%B6then%2C%20Markus%20M">Nöthen, Markus M</a>; </li><li><a href="/search/?q=author%3AO%E2%80%99Donovan%2C%20Michael%20C">O’Donovan, Michael C</a>; </li><li><a href="/search/?q=author%3AOedegaard%2C%20Ketil%20J">Oedegaard, Ketil J</a>; </li><li><a href="/search/?q=author%3AOwen%2C%20Michael%20J">Owen, Michael J</a>; </li><li><a href="/search/?q=author%3APaciga%2C%20Sara%20A">Paciga, Sara A</a>; </li><li><a href="/search/?q=author%3APato%2C%20Carlos">Pato, Carlos</a>; </li><li><a href="/search/?q=author%3APato%2C%20Michele%20T">Pato, Michele T</a>; </li><li><a href="/search/?q=author%3APosthuma%2C%20Danielle">Posthuma, Danielle</a>; </li><li><a href="/search/?q=author%3ARamos-Quiroga%2C%20Josep%20Antoni">Ramos-Quiroga, Josep Antoni</a>; </li><li><a href="/search/?q=author%3ARibase%C3%ACs%2C%20Marta">Ribaseìs, Marta</a>; </li><li><a href="/search/?q=author%3ARietschel%2C%20Marcella">Rietschel, Marcella</a>; </li><li><a href="/search/?q=author%3ARouleau%2C%20Guy%20A">Rouleau, Guy A</a>; </li><li><a href="/search/?q=author%3ASchalling%2C%20Martin">Schalling, Martin</a>; </li><li><a href="/search/?q=author%3ASchofield%2C%20Peter%20R">Schofield, Peter R</a>; </li><li><a href="/search/?q=author%3ASchulze%2C%20Thomas%20G">Schulze, Thomas G</a>; </li><li><a href="/search/?q=author%3ASerretti%2C%20Alessandro">Serretti, Alessandro</a>; </li><li><a href="/search/?q=author%3ASmoller%2C%20Jordan%20W">Smoller, Jordan W</a>; </li><li><a href="/search/?q=author%3AStefansson%2C%20Hreinn">Stefansson, Hreinn</a>; </li><li><a href="/search/?q=author%3AStefansson%2C%20Kari">Stefansson, Kari</a>; </li><li><a href="/search/?q=author%3AStordal%2C%20Eystein">Stordal, Eystein</a>; </li><li><a href="/search/?q=author%3ASullivan%2C%20Patrick%20F">Sullivan, Patrick F</a>; </li><li><a href="/search/?q=author%3ATurecki%2C%20Gustavo">Turecki, Gustavo</a>; </li><li><a href="/search/?q=author%3AVaaler%2C%20Arne%20E">Vaaler, Arne E</a>; </li><li><a href="/search/?q=author%3AVieta%2C%20Eduard">Vieta, Eduard</a>; </li><li><a href="/search/?q=author%3AVincent%2C%20John%20B">Vincent, John B</a>; </li><li><a href="/search/?q=author%3AWerge%2C%20Thomas">Werge, Thomas</a>; </li><li><a href="/search/?q=author%3ANurnberger%2C%20John%20I">Nurnberger, John I</a>; </li><li><a href="/search/?q=author%3AWray%2C%20Naomi%20R">Wray, Naomi R</a>; </li><li><a href="/search/?q=author%3ADi%20Florio%2C%20Arianna">Di Florio, Arianna</a>; </li><li><a href="/search/?q=author%3AEdenberg%2C%20Howard%20J">Edenberg, Howard J</a>; </li><li><a href="/search/?q=author%3ACichon%2C%20Sven">Cichon, Sven</a>; </li><li><a href="/search/?q=author%3AOphoff%2C%20Roel%20A">Ophoff, Roel A</a>; </li><li><a href="/search/?q=author%3AScott%2C%20Laura%20J">Scott, Laura J</a>; </li><li><a href="/search/?q=author%3AAndreassen%2C%20Ole%20A">Andreassen, Ole A</a>; </li><li><a href="/search/?q=author%3AKelsoe%2C%20John">Kelsoe, John</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3ASklar%2C%20Pamela">Sklar, Pamela</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucla_postprints">UCLA Previously Published Works</a> (2019)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup"><b>Background:</b> Alzheimer's disease (AD) and bipolar disorder (BIP) are complex traits influenced by numerous common genetic variants, most of which remain to be detected. Clinical and epidemiological evidence suggest that AD and BIP are related. However, it is not established if this relation is of genetic origin. Here, we applied statistical methods based on the conditional false discovery rate (FDR) framework to detect genetic overlap between AD and BIP and utilized this overlap to increase the power to identify common genetic variants associated with either or both traits. <b>Methods:</b> We obtained genome wide association studies data from the International Genomics of Alzheimer's Project part 1 (17,008 AD cases and 37,154 controls) and the Psychiatric Genetic Consortium Bipolar Disorder Working Group (20,352 BIP cases and 31,358 controls). We used conditional QQ-plots to assess overlap in common genetic variants between AD and BIP. We exploited the genetic overlap to re-rank test-statistics for AD and BIP and improve detection of genetic variants using the conditional FDR framework. <b>Results:</b> Conditional QQ-plots demonstrated a polygenic overlap between AD and BIP. Using conditional FDR, we identified one novel genomic locus associated with AD, and nine novel loci associated with BIP. Further, we identified two novel loci jointly associated with AD and BIP implicating the <i>MARK2</i> gene (lead SNP rs10792421, conjunctional FDR = 0.030, same direction of effect) and the <i>VAC14</i> gene (lead SNP rs11649476, conjunctional FDR = 0.022, opposite direction of effect). <b>Conclusion:</b> We found polygenic overlap between AD and BIP and identified novel loci for each trait and two jointly associated loci. Further studies should examine if the shared loci implicating the <i>MARK2</i> and <i>VAC14</i> genes could explain parts of the shared and distinct features of AD and BIP.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/1rb9b4d6"><img src="/cms-assets/99ac4e3376a934acd2ad9aa4de10bc059a4008e3efb3766050f2db162427eee9" alt="Cover page: Genetic Overlap Between Alzheimer’s Disease and Bipolar Disorder Implicates the MARK2 and VAC14 Genes"/></a><a href="https://creativecommons.org/licenses/by/4.0/" class="c-scholworks__license"><img class="c-lazyimage" data-src="/images/cc-by-small.svg" alt="Creative Commons 'BY' version 4.0 license"/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/2zn5v9k5"><div class="c-clientmarkup">Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3AMullins%2C%20Niamh">Mullins, Niamh</a>; </li><li><a href="/search/?q=author%3AForstner%2C%20Andreas%20J">Forstner, Andreas J</a>; </li><li><a href="/search/?q=author%3AO%E2%80%99Connell%2C%20Kevin%20S">O’Connell, Kevin S</a>; </li><li><a href="/search/?q=author%3ACoombes%2C%20Brandon">Coombes, Brandon</a>; </li><li><a href="/search/?q=author%3AColeman%2C%20Jonathan%20RI">Coleman, Jonathan RI</a>; </li><li><a href="/search/?q=author%3AQiao%2C%20Zhen">Qiao, Zhen</a>; </li><li><a href="/search/?q=author%3AAls%2C%20Thomas%20D">Als, Thomas D</a>; </li><li><a href="/search/?q=author%3ABigdeli%2C%20Tim%20B">Bigdeli, Tim B</a>; </li><li><a href="/search/?q=author%3AB%C3%B8rte%2C%20Sigrid">Børte, Sigrid</a>; </li><li><a href="/search/?q=author%3ABryois%2C%20Julien">Bryois, Julien</a>; </li><li><a href="/search/?q=author%3ACharney%2C%20Alexander%20W">Charney, Alexander W</a>; </li><li><a href="/search/?q=author%3ADrange%2C%20Ole%20Kristian">Drange, Ole Kristian</a>; </li><li><a href="/search/?q=author%3AGandal%2C%20Michael%20J">Gandal, Michael J</a>; </li><li><a href="/search/?q=author%3AHagenaars%2C%20Saskia%20P">Hagenaars, Saskia P</a>; </li><li><a href="/search/?q=author%3AIkeda%2C%20Masashi">Ikeda, Masashi</a>; </li><li><a href="/search/?q=author%3AKamitaki%2C%20Nolan">Kamitaki, Nolan</a>; </li><li><a href="/search/?q=author%3AKim%2C%20Minsoo">Kim, Minsoo</a>; </li><li><a href="/search/?q=author%3AKrebs%2C%20Kristi">Krebs, Kristi</a>; </li><li><a href="/search/?q=author%3APanagiotaropoulou%2C%20Georgia">Panagiotaropoulou, Georgia</a>; </li><li><a href="/search/?q=author%3ASchilder%2C%20Brian%20M">Schilder, Brian M</a>; </li><li><a href="/search/?q=author%3ASloofman%2C%20Laura%20G">Sloofman, Laura G</a>; </li><li><a href="/search/?q=author%3ASteinberg%2C%20Stacy">Steinberg, Stacy</a>; </li><li><a href="/search/?q=author%3ATrubetskoy%2C%20Vassily">Trubetskoy, Vassily</a>; </li><li><a href="/search/?q=author%3AWinsvold%2C%20Bendik%20S">Winsvold, Bendik S</a>; </li><li><a href="/search/?q=author%3AWon%2C%20Hong-Hee">Won, Hong-Hee</a>; </li><li><a href="/search/?q=author%3AAbramova%2C%20Liliya">Abramova, Liliya</a>; </li><li><a href="/search/?q=author%3AAdorjan%2C%20Kristina">Adorjan, Kristina</a>; </li><li><a href="/search/?q=author%3AAgerbo%2C%20Esben">Agerbo, Esben</a>; </li><li><a href="/search/?q=author%3AAl%20Eissa%2C%20Mariam">Al Eissa, Mariam</a>; </li><li><a href="/search/?q=author%3AAlbani%2C%20Diego">Albani, Diego</a>; </li><li><a href="/search/?q=author%3AAlliey-Rodriguez%2C%20Ney">Alliey-Rodriguez, Ney</a>; </li><li><a href="/search/?q=author%3AAnjorin%2C%20Adebayo">Anjorin, Adebayo</a>; </li><li><a href="/search/?q=author%3AAntilla%2C%20Verneri">Antilla, Verneri</a>; </li><li><a href="/search/?q=author%3AAntoniou%2C%20Anastasia">Antoniou, Anastasia</a>; </li><li><a href="/search/?q=author%3AAwasthi%2C%20Swapnil">Awasthi, Swapnil</a>; </li><li><a href="/search/?q=author%3ABaek%2C%20Ji%20Hyun">Baek, Ji Hyun</a>; </li><li><a href="/search/?q=author%3AB%C3%A6kvad-Hansen%2C%20Marie">Bækvad-Hansen, Marie</a>; </li><li><a href="/search/?q=author%3ABass%2C%20Nicholas">Bass, Nicholas</a>; </li><li><a href="/search/?q=author%3ABauer%2C%20Michael">Bauer, Michael</a>; </li><li><a href="/search/?q=author%3ABeins%2C%20Eva%20C">Beins, Eva C</a>; </li><li><a href="/search/?q=author%3ABergen%2C%20Sarah%20E">Bergen, Sarah E</a>; </li><li><a href="/search/?q=author%3ABirner%2C%20Armin">Birner, Armin</a>; </li><li><a href="/search/?q=author%3AB%C3%B8cker%20Pedersen%2C%20Carsten">Bøcker Pedersen, Carsten</a>; </li><li><a href="/search/?q=author%3AB%C3%B8en%2C%20Erlend">Bøen, Erlend</a>; </li><li><a href="/search/?q=author%3ABoks%2C%20Marco%20P">Boks, Marco P</a>; </li><li><a href="/search/?q=author%3ABosch%2C%20Rosa">Bosch, Rosa</a>; </li><li><a href="/search/?q=author%3ABrum%2C%20Murielle">Brum, Murielle</a>; </li><li><a href="/search/?q=author%3ABrumpton%2C%20Ben%20M">Brumpton, Ben M</a>; </li><li><a href="/search/?q=author%3ABrunkhorst-Kanaan%2C%20Nathalie">Brunkhorst-Kanaan, Nathalie</a>; </li><li><a href="/search/?q=author%3ABudde%2C%20Monika">Budde, Monika</a>; </li><li><a href="/search/?q=author%3ABybjerg-Grauholm%2C%20Jonas">Bybjerg-Grauholm, Jonas</a>; </li><li><a href="/search/?q=author%3AByerley%2C%20William">Byerley, William</a>; </li><li><a href="/search/?q=author%3ACairns%2C%20Murray">Cairns, Murray</a>; </li><li><a href="/search/?q=author%3ACasas%2C%20Miquel">Casas, Miquel</a>; </li><li><a href="/search/?q=author%3ACervantes%2C%20Pablo">Cervantes, Pablo</a>; </li><li><a href="/search/?q=author%3AClarke%2C%20Toni-Kim">Clarke, Toni-Kim</a>; </li><li><a href="/search/?q=author%3ACruceanu%2C%20Cristiana">Cruceanu, Cristiana</a>; </li><li><a href="/search/?q=author%3ACuellar-Barboza%2C%20Alfredo">Cuellar-Barboza, Alfredo</a>; </li><li><a href="/search/?q=author%3ACunningham%2C%20Julie">Cunningham, Julie</a>; </li><li><a href="/search/?q=author%3ACurtis%2C%20David">Curtis, David</a>; </li><li><a href="/search/?q=author%3ACzerski%2C%20Piotr%20M">Czerski, Piotr M</a>; </li><li><a href="/search/?q=author%3ADale%2C%20Anders%20M">Dale, Anders M</a>; </li><li><a href="/search/?q=author%3ADalkner%2C%20Nina">Dalkner, Nina</a>; </li><li><a href="/search/?q=author%3ADavid%2C%20Friederike%20S">David, Friederike S</a>; </li><li><a href="/search/?q=author%3ADegenhardt%2C%20Franziska">Degenhardt, Franziska</a>; </li><li><a href="/search/?q=author%3ADjurovic%2C%20Srdjan">Djurovic, Srdjan</a>; </li><li><a href="/search/?q=author%3ADobbyn%2C%20Amanda%20L">Dobbyn, Amanda L</a>; </li><li><a href="/search/?q=author%3ADouzenis%2C%20Athanassios">Douzenis, Athanassios</a>; </li><li><a href="/search/?q=author%3AElvs%C3%A5shagen%2C%20Torbj%C3%B8rn">Elvsåshagen, Torbjørn</a>; </li><li><a href="/search/?q=author%3AEscott-Price%2C%20Valentina">Escott-Price, Valentina</a>; </li><li><a href="/search/?q=author%3AFerrier%2C%20I%20Nicol">Ferrier, I Nicol</a>; </li><li><a href="/search/?q=author%3AFiorentino%2C%20Alessia">Fiorentino, Alessia</a>; </li><li><a href="/search/?q=author%3AForoud%2C%20Tatiana%20M">Foroud, Tatiana M</a>; </li><li><a href="/search/?q=author%3AForty%2C%20Liz">Forty, Liz</a>; </li><li><a href="/search/?q=author%3AFrank%2C%20Josef">Frank, Josef</a>; </li><li><a href="/search/?q=author%3AFrei%2C%20Oleksandr">Frei, Oleksandr</a>; </li><li><a href="/search/?q=author%3AFreimer%2C%20Nelson%20B">Freimer, Nelson B</a>; </li><li><a href="/search/?q=author%3AFris%C3%A9n%2C%20Louise">Frisén, Louise</a>; </li><li><a href="/search/?q=author%3AGade%2C%20Katrin">Gade, Katrin</a>; </li><li><a href="/search/?q=author%3AGarnham%2C%20Julie">Garnham, Julie</a>; </li><li><a href="/search/?q=author%3AGelernter%2C%20Joel">Gelernter, Joel</a>; </li><li><a href="/search/?q=author%3AGi%C3%B8rtz%20Pedersen%2C%20Marianne">Giørtz Pedersen, Marianne</a>; </li><li><a href="/search/?q=author%3AGizer%2C%20Ian%20R">Gizer, Ian R</a>; </li><li><a href="/search/?q=author%3AGordon%2C%20Scott%20D">Gordon, Scott D</a>; </li><li><a href="/search/?q=author%3AGordon-Smith%2C%20Katherine">Gordon-Smith, Katherine</a>; </li><li><a href="/search/?q=author%3AGreenwood%2C%20Tiffany%20A">Greenwood, Tiffany A</a>; </li><li><a href="/search/?q=author%3AGrove%2C%20Jakob">Grove, Jakob</a>; </li><li><a href="/search/?q=author%3AGuzman-Parra%2C%20Jos%C3%A9">Guzman-Parra, José</a>; </li><li><a href="/search/?q=author%3AHa%2C%20Kyooseob">Ha, Kyooseob</a>; </li><li><a href="/search/?q=author%3AHaraldsson%2C%20Magnus">Haraldsson, Magnus</a>; </li><li><a href="/search/?q=author%3AHautzinger%2C%20Martin">Hautzinger, Martin</a>; </li><li><a href="/search/?q=author%3AHeilbronner%2C%20Urs">Heilbronner, Urs</a>; </li><li><a href="/search/?q=author%3AHellgren%2C%20Dennis">Hellgren, Dennis</a>; </li><li><a href="/search/?q=author%3AHerms%2C%20Stefan">Herms, Stefan</a>; </li><li><a href="/search/?q=author%3AHoffmann%2C%20Per">Hoffmann, Per</a>; </li><li><a href="/search/?q=author%3AHolmans%2C%20Peter%20A">Holmans, Peter A</a>; </li><li><a href="/search/?q=author%3AHuckins%2C%20Laura">Huckins, Laura</a>; </li><li><a href="/search/?q=author%3AJamain%2C%20St%C3%A9phane">Jamain, Stéphane</a>; </li><li><a href="/search/?q=author%3AJohnson%2C%20Jessica%20S">Johnson, Jessica S</a>; </li><li><a href="/search/?q=author%3AKalman%2C%20Janos%20L">Kalman, Janos L</a>; </li><li><a href="/search/?q=author%3AKamatani%2C%20Yoichiro">Kamatani, Yoichiro</a>; </li><li><a href="/search/?q=author%3AKennedy%2C%20James%20L">Kennedy, James L</a>; </li><li><a href="/search/?q=author%3AKittel-Schneider%2C%20Sarah">Kittel-Schneider, Sarah</a>; </li><li><a href="/search/?q=author%3AKnowles%2C%20James%20A">Knowles, James A</a>; </li><li><a href="/search/?q=author%3AKogevinas%2C%20Manolis">Kogevinas, Manolis</a>; </li><li><a href="/search/?q=author%3AKoromina%2C%20Maria">Koromina, Maria</a>; </li><li><a href="/search/?q=author%3AKranz%2C%20Thorsten%20M">Kranz, Thorsten M</a>; </li><li><a href="/search/?q=author%3AKranzler%2C%20Henry%20R">Kranzler, Henry R</a>; </li><li><a href="/search/?q=author%3AKubo%2C%20Michiaki">Kubo, Michiaki</a>; </li><li><a href="/search/?q=author%3AKupka%2C%20Ralph">Kupka, Ralph</a>; </li><li><a href="/search/?q=author%3AKushner%2C%20Steven%20A">Kushner, Steven A</a>; </li><li><a href="/search/?q=author%3ALavebratt%2C%20Catharina">Lavebratt, Catharina</a>; </li><li><a href="/search/?q=author%3ALawrence%2C%20Jacob">Lawrence, Jacob</a>; </li><li><a href="/search/?q=author%3ALeber%2C%20Markus">Leber, Markus</a>; </li><li><a href="/search/?q=author%3ALee%2C%20Heon-Jeong">Lee, Heon-Jeong</a>; </li><li><a href="/search/?q=author%3ALee%2C%20Phil%20H">Lee, Phil H</a>; </li><li><a href="/search/?q=author%3ALevy%2C%20Shawn%20E">Levy, Shawn E</a>; </li><li><a href="/search/?q=author%3ALewis%2C%20Catrin">Lewis, Catrin</a>; </li><li><a href="/search/?q=author%3ALiao%2C%20Calwing">Liao, Calwing</a>; </li><li><a href="/search/?q=author%3ALucae%2C%20Susanne">Lucae, Susanne</a>; </li><li><a href="/search/?q=author%3ALundberg%2C%20Martin">Lundberg, Martin</a>; </li><li><a href="/search/?q=author%3AMacIntyre%2C%20Donald%20J">MacIntyre, Donald J</a>; </li><li><a href="/search/?q=author%3AMagnusson%2C%20Sigurdur%20H">Magnusson, Sigurdur H</a>; </li><li><a href="/search/?q=author%3AMaier%2C%20Wolfgang">Maier, Wolfgang</a>; </li><li><a href="/search/?q=author%3AMaihofer%2C%20Adam">Maihofer, Adam</a>; </li><li><a href="/search/?q=author%3AMalaspina%2C%20Dolores">Malaspina, Dolores</a>; </li><li><a href="/search/?q=author%3AMaratou%2C%20Eirini">Maratou, Eirini</a>; </li><li><a href="/search/?q=author%3AMartinsson%2C%20Lina">Martinsson, Lina</a>; </li><li><a href="/search/?q=author%3AMattheisen%2C%20Manuel">Mattheisen, Manuel</a>; </li><li><a href="/search/?q=author%3AMcCarroll%2C%20Steven%20A">McCarroll, Steven A</a>; </li><li><a href="/search/?q=author%3AMcGregor%2C%20Nathaniel%20W">McGregor, Nathaniel W</a>; </li><li><a href="/search/?q=author%3AMcGuffin%2C%20Peter">McGuffin, Peter</a>; </li><li><a href="/search/?q=author%3AMcKay%2C%20James%20D">McKay, James D</a>; </li><li><a href="/search/?q=author%3AMedeiros%2C%20Helena">Medeiros, Helena</a>; </li><li><a href="/search/?q=author%3AMedland%2C%20Sarah%20E">Medland, Sarah E</a>; </li><li><a href="/search/?q=author%3AMillischer%2C%20Vincent">Millischer, Vincent</a>; </li><li><a href="/search/?q=author%3AMontgomery%2C%20Grant%20W">Montgomery, Grant W</a>; </li><li><a href="/search/?q=author%3AMoran%2C%20Jennifer%20L">Moran, Jennifer L</a>; </li><li><a href="/search/?q=author%3AMorris%2C%20Derek%20W">Morris, Derek W</a>; </li><li><a href="/search/?q=author%3AM%C3%BChleisen%2C%20Thomas%20W">Mühleisen, Thomas W</a>; </li><li><a href="/search/?q=author%3AO%E2%80%99Brien%2C%20Niamh">O’Brien, Niamh</a>; </li><li><a href="/search/?q=author%3AO%E2%80%99Donovan%2C%20Claire">O’Donovan, Claire</a>; </li><li><a href="/search/?q=author%3AOlde%20Loohuis%2C%20Loes%20M">Olde Loohuis, Loes M</a>; </li><li><a href="/search/?q=author%3AOruc%2C%20Lilijana">Oruc, Lilijana</a>; </li><li><a href="/search/?q=author%3APapiol%2C%20Sergi">Papiol, Sergi</a>; </li><li><a href="/search/?q=author%3APardi%C3%B1as%2C%20Antonio%20F">Pardiñas, Antonio F</a>; </li><li><a href="/search/?q=author%3APerry%2C%20Amy">Perry, Amy</a>; </li><li><a href="/search/?q=author%3APfennig%2C%20Andrea">Pfennig, Andrea</a>; </li><li><a href="/search/?q=author%3APorichi%2C%20Evgenia">Porichi, Evgenia</a>; </li><li><a href="/search/?q=author%3APotash%2C%20James%20B">Potash, James B</a>; </li><li><a href="/search/?q=author%3AQuested%2C%20Digby">Quested, Digby</a>; </li><li><a href="/search/?q=author%3ARaj%2C%20Towfique">Raj, Towfique</a>; </li><li><a href="/search/?q=author%3ARapaport%2C%20Mark%20H">Rapaport, Mark H</a>; </li><li><a href="/search/?q=author%3ADePaulo%2C%20J%20Raymond">DePaulo, J Raymond</a>; </li><li><a href="/search/?q=author%3ARegeer%2C%20Eline%20J">Regeer, Eline J</a>; </li><li><a href="/search/?q=author%3ARice%2C%20John%20P">Rice, John P</a>; </li><li><a href="/search/?q=author%3ARivas%2C%20Fabio">Rivas, Fabio</a>; </li><li><a href="/search/?q=author%3ARivera%2C%20Margarita">Rivera, Margarita</a>; </li><li><a href="/search/?q=author%3ARoth%2C%20Julian">Roth, Julian</a>; </li><li><a href="/search/?q=author%3ARoussos%2C%20Panos">Roussos, Panos</a>; </li><li><a href="/search/?q=author%3ARuderfer%2C%20Douglas%20M">Ruderfer, Douglas M</a>; </li><li><a href="/search/?q=author%3AS%C3%A1nchez-Mora%2C%20Cristina">Sánchez-Mora, Cristina</a>; </li><li><a href="/search/?q=author%3ASchulte%2C%20Eva%20C">Schulte, Eva C</a>; </li><li><a href="/search/?q=author%3ASenner%2C%20Fanny">Senner, Fanny</a>; </li><li><a href="/search/?q=author%3ASharp%2C%20Sally">Sharp, Sally</a>; </li><li><a href="/search/?q=author%3AShilling%2C%20Paul%20D">Shilling, Paul D</a>; </li><li><a href="/search/?q=author%3ASigurdsson%2C%20Engilbert">Sigurdsson, Engilbert</a>; </li><li><a href="/search/?q=author%3ASirignano%2C%20Lea">Sirignano, Lea</a>; </li><li><a href="/search/?q=author%3ASlaney%2C%20Claire">Slaney, Claire</a>; </li><li><a href="/search/?q=author%3ASmeland%2C%20Olav%20B">Smeland, Olav B</a>; </li><li><a href="/search/?q=author%3ASmith%2C%20Daniel%20J">Smith, Daniel J</a>; </li><li><a href="/search/?q=author%3ASobell%2C%20Janet%20L">Sobell, Janet L</a>; </li><li><a href="/search/?q=author%3AS%C3%B8holm%20Hansen%2C%20Christine">Søholm Hansen, Christine</a>; </li><li><a href="/search/?q=author%3ASoler%20Artigas%2C%20Maria">Soler Artigas, Maria</a>; </li><li><a href="/search/?q=author%3ASpijker%2C%20Anne%20T">Spijker, Anne T</a>; </li><li><a href="/search/?q=author%3AStein%2C%20Dan%20J">Stein, Dan J</a>; </li><li><a href="/search/?q=author%3AStrauss%2C%20John%20S">Strauss, John S</a>; </li><li><a href="/search/?q=author%3A%C5%9Awi%C4%85tkowska%2C%20Beata">Świątkowska, Beata</a>; </li><li><a href="/search/?q=author%3ATerao%2C%20Chikashi">Terao, Chikashi</a>; </li><li><a href="/search/?q=author%3AThorgeirsson%2C%20Thorgeir%20E">Thorgeirsson, Thorgeir E</a>; </li><li><a href="/search/?q=author%3AToma%2C%20Claudio">Toma, Claudio</a>; </li><li><a href="/search/?q=author%3ATooney%2C%20Paul">Tooney, Paul</a>; </li><li><a href="/search/?q=author%3ATsermpini%2C%20Evangelia-Eirini">Tsermpini, Evangelia-Eirini</a>; </li><li><a href="/search/?q=author%3AVawter%2C%20Marquis%20P">Vawter, Marquis P</a>; </li><li><a href="/search/?q=author%3AVedder%2C%20Helmut">Vedder, Helmut</a>; </li><li><a href="/search/?q=author%3AWalters%2C%20James%20TR">Walters, James TR</a>; </li><li><a href="/search/?q=author%3AWitt%2C%20Stephanie%20H">Witt, Stephanie H</a>; </li><li><a href="/search/?q=author%3AXi%2C%20Simon">Xi, Simon</a>; </li><li><a href="/search/?q=author%3AXu%2C%20Wei">Xu, Wei</a>; </li><li><a href="/search/?q=author%3AYang%2C%20Jessica%20Mei%20Kay">Yang, Jessica Mei Kay</a>; </li><li><a href="/search/?q=author%3AYoung%2C%20Allan%20H">Young, Allan H</a>; </li><li><a href="/search/?q=author%3AYoung%2C%20Hannah">Young, Hannah</a>; </li><li><a href="/search/?q=author%3AZandi%2C%20Peter%20P">Zandi, Peter P</a>; </li><li><a href="/search/?q=author%3AZhou%2C%20Hang">Zhou, Hang</a>; </li><li><a href="/search/?q=author%3AZillich%2C%20Lea">Zillich, Lea</a>; </li><li><a href="/search/?q=author%3AAdolfsson%2C%20Rolf">Adolfsson, Rolf</a>; </li><li><a href="/search/?q=author%3AAgartz%2C%20Ingrid">Agartz, Ingrid</a>; </li><li><a href="/search/?q=author%3AAlda%2C%20Martin">Alda, Martin</a>; </li><li><a href="/search/?q=author%3AAlfredsson%2C%20Lars">Alfredsson, Lars</a>; </li><li><a href="/search/?q=author%3ABabadjanova%2C%20Gulja">Babadjanova, Gulja</a>; </li><li><a href="/search/?q=author%3ABacklund%2C%20Lena">Backlund, Lena</a>; </li><li><a href="/search/?q=author%3ABaune%2C%20Bernhard%20T">Baune, Bernhard T</a>; </li><li><a href="/search/?q=author%3ABellivier%2C%20Frank">Bellivier, Frank</a>; </li><li><a href="/search/?q=author%3ABengesser%2C%20Susanne">Bengesser, Susanne</a>; </li><li><a href="/search/?q=author%3ABerrettini%2C%20Wade%20H">Berrettini, Wade H</a>; </li><li><a href="/search/?q=author%3ABlackwood%2C%20Douglas%20HR">Blackwood, Douglas HR</a>; </li><li><a href="/search/?q=author%3ABoehnke%2C%20Michael">Boehnke, Michael</a>; </li><li><a href="/search/?q=author%3AB%C3%B8rglum%2C%20Anders%20D">Børglum, Anders D</a>; </li><li><a href="/search/?q=author%3ABreen%2C%20Gerome">Breen, Gerome</a>; </li><li><a href="/search/?q=author%3ACarr%2C%20Vaughan%20J">Carr, Vaughan J</a>; </li><li><a href="/search/?q=author%3ACatts%2C%20Stanley">Catts, Stanley</a>; </li><li><a href="/search/?q=author%3ACorvin%2C%20Aiden">Corvin, Aiden</a>; </li><li><a href="/search/?q=author%3ACraddock%2C%20Nicholas">Craddock, Nicholas</a>; </li><li><a href="/search/?q=author%3ADannlowski%2C%20Udo">Dannlowski, Udo</a>; </li><li><a href="/search/?q=author%3ADikeos%2C%20Dimitris">Dikeos, Dimitris</a>; </li><li><a href="/search/?q=author%3AEsko%2C%20T%C3%B5nu">Esko, Tõnu</a>; </li><li><a href="/search/?q=author%3AEtain%2C%20Bruno">Etain, Bruno</a>; </li><li><a href="/search/?q=author%3AFerentinos%2C%20Panagiotis">Ferentinos, Panagiotis</a>; </li><li><a href="/search/?q=author%3AFrye%2C%20Mark">Frye, Mark</a>; </li><li><a href="/search/?q=author%3AFullerton%2C%20Janice%20M">Fullerton, Janice M</a>; </li><li><a href="/search/?q=author%3AGawlik%2C%20Micha">Gawlik, Micha</a>; </li><li><a href="/search/?q=author%3AGershon%2C%20Elliot%20S">Gershon, Elliot S</a>; </li><li><a href="/search/?q=author%3AGoes%2C%20Fernando%20S">Goes, Fernando S</a>; </li><li><a href="/search/?q=author%3AGreen%2C%20Melissa%20J">Green, Melissa J</a>; </li><li><a href="/search/?q=author%3AGrigoroiu-Serbanescu%2C%20Maria">Grigoroiu-Serbanescu, Maria</a>; </li><li><a href="/search/?q=author%3AHauser%2C%20Joanna">Hauser, Joanna</a>; </li><li><a href="/search/?q=author%3AHenskens%2C%20Frans">Henskens, Frans</a>; </li><li><a href="/search/?q=author%3AHillert%2C%20Jan">Hillert, Jan</a>; </li><li><a href="/search/?q=author%3AHong%2C%20Kyung%20Sue">Hong, Kyung Sue</a>; </li><li><a href="/search/?q=author%3AHougaard%2C%20David%20M">Hougaard, David M</a>; </li><li><a href="/search/?q=author%3AHultman%2C%20Christina%20M">Hultman, Christina M</a>; </li><li><a href="/search/?q=author%3AHveem%2C%20Kristian">Hveem, Kristian</a>; </li><li><a href="/search/?q=author%3AIwata%2C%20Nakao">Iwata, Nakao</a>; </li><li><a href="/search/?q=author%3AJablensky%2C%20Assen%20V">Jablensky, Assen V</a>; </li><li><a href="/search/?q=author%3AJones%2C%20Ian">Jones, Ian</a>; </li><li><a href="/search/?q=author%3AJones%2C%20Lisa%20A">Jones, Lisa A</a>; </li><li><a href="/search/?q=author%3AKahn%2C%20Ren%C3%A9%20S">Kahn, René S</a>; </li><li><a href="/search/?q=author%3AKelsoe%2C%20John%20R">Kelsoe, John R</a>; </li><li><a href="/search/?q=author%3AKirov%2C%20George">Kirov, George</a>; </li><li><a href="/search/?q=author%3ALand%C3%A9n%2C%20Mikael">Landén, Mikael</a>; </li><li><a href="/search/?q=author%3ALeboyer%2C%20Marion">Leboyer, Marion</a>; </li><li><a href="/search/?q=author%3ALewis%2C%20Cathryn%20M">Lewis, Cathryn M</a>; </li><li><a href="/search/?q=author%3ALi%2C%20Qingqin%20S">Li, Qingqin S</a>; </li><li><a href="/search/?q=author%3ALissowska%2C%20Jolanta">Lissowska, Jolanta</a>; </li><li><a href="/search/?q=author%3ALochner%2C%20Christine">Lochner, Christine</a>; </li><li><a href="/search/?q=author%3ALoughland%2C%20Carmel">Loughland, Carmel</a>; </li><li><a href="/search/?q=author%3AMartin%2C%20Nicholas%20G">Martin, Nicholas G</a>; </li><li><a href="/search/?q=author%3AMathews%2C%20Carol%20A">Mathews, Carol A</a>; </li><li><a href="/search/?q=author%3AMayoral%2C%20Fermin">Mayoral, Fermin</a>; </li><li><a href="/search/?q=author%3AMcElroy%2C%20Susan%20L">McElroy, Susan L</a>; </li><li><a href="/search/?q=author%3AMcIntosh%2C%20Andrew%20M">McIntosh, Andrew M</a>; </li><li><a href="/search/?q=author%3AMcMahon%2C%20Francis%20J">McMahon, Francis J</a>; </li><li><a href="/search/?q=author%3AMelle%2C%20Ingrid">Melle, Ingrid</a>; </li><li><a href="/search/?q=author%3AMichie%2C%20Patricia">Michie, Patricia</a>; </li><li><a href="/search/?q=author%3AMilani%2C%20Lili">Milani, Lili</a>; </li><li><a href="/search/?q=author%3AMitchell%2C%20Philip%20B">Mitchell, Philip B</a>; </li><li><a href="/search/?q=author%3AMorken%2C%20Gunnar">Morken, Gunnar</a>; </li><li><a href="/search/?q=author%3AMors%2C%20Ole">Mors, Ole</a>; </li><li><a href="/search/?q=author%3AMortensen%2C%20Preben%20Bo">Mortensen, Preben Bo</a>; </li><li><a href="/search/?q=author%3AMowry%2C%20Bryan">Mowry, Bryan</a>; </li><li><a href="/search/?q=author%3AM%C3%BCller-Myhsok%2C%20Bertram">Müller-Myhsok, Bertram</a>; </li><li><a href="/search/?q=author%3AMyers%2C%20Richard%20M">Myers, Richard M</a>; </li><li><a href="/search/?q=author%3ANeale%2C%20Benjamin%20M">Neale, Benjamin M</a>; </li><li><a href="/search/?q=author%3ANievergelt%2C%20Caroline%20M">Nievergelt, Caroline M</a>; </li><li><a href="/search/?q=author%3ANordentoft%2C%20Merete">Nordentoft, Merete</a>; </li><li><a href="/search/?q=author%3AN%C3%B6then%2C%20Markus%20M">Nöthen, Markus M</a>; </li><li><a href="/search/?q=author%3AO%E2%80%99Donovan%2C%20Michael%20C">O’Donovan, Michael C</a>; </li><li><a href="/search/?q=author%3AOedegaard%2C%20Ketil%20J">Oedegaard, Ketil J</a>; </li><li><a href="/search/?q=author%3AOlsson%2C%20Tomas">Olsson, Tomas</a>; </li><li><a href="/search/?q=author%3AOwen%2C%20Michael%20J">Owen, Michael J</a>; </li><li><a href="/search/?q=author%3APaciga%2C%20Sara%20A">Paciga, Sara A</a>; </li><li><a href="/search/?q=author%3APantelis%2C%20Chris">Pantelis, Chris</a>; </li><li><a href="/search/?q=author%3APato%2C%20Carlos">Pato, Carlos</a>; </li><li><a href="/search/?q=author%3APato%2C%20Michele%20T">Pato, Michele T</a>; </li><li><a href="/search/?q=author%3APatrinos%2C%20George%20P">Patrinos, George P</a>; </li><li><a href="/search/?q=author%3APerlis%2C%20Roy%20H">Perlis, Roy H</a>; </li><li><a href="/search/?q=author%3APosthuma%2C%20Danielle">Posthuma, Danielle</a>; </li><li><a href="/search/?q=author%3ARamos-Quiroga%2C%20Josep%20Antoni">Ramos-Quiroga, Josep Antoni</a>; </li><li><a href="/search/?q=author%3AReif%2C%20Andreas">Reif, Andreas</a>; </li><li><a href="/search/?q=author%3AReininghaus%2C%20Eva%20Z">Reininghaus, Eva Z</a>; </li><li><a href="/search/?q=author%3ARibas%C3%A9s%2C%20Marta">Ribasés, Marta</a>; </li><li><a href="/search/?q=author%3ARietschel%2C%20Marcella">Rietschel, Marcella</a>; </li><li><a href="/search/?q=author%3ARipke%2C%20Stephan">Ripke, Stephan</a>; </li><li><a href="/search/?q=author%3ARouleau%2C%20Guy%20A">Rouleau, Guy A</a>; </li><li><a href="/search/?q=author%3ASaito%2C%20Takeo">Saito, Takeo</a>; </li><li><a href="/search/?q=author%3ASchall%2C%20Ulrich">Schall, Ulrich</a>; </li><li><a href="/search/?q=author%3ASchalling%2C%20Martin">Schalling, Martin</a>; </li><li><a href="/search/?q=author%3ASchofield%2C%20Peter%20R">Schofield, Peter R</a>; </li><li><a href="/search/?q=author%3ASchulze%2C%20Thomas%20G">Schulze, Thomas G</a>; </li><li><a href="/search/?q=author%3AScott%2C%20Laura%20J">Scott, Laura J</a>; </li><li><a href="/search/?q=author%3AScott%2C%20Rodney%20J">Scott, Rodney J</a>; </li><li><a href="/search/?q=author%3ASerretti%2C%20Alessandro">Serretti, Alessandro</a>; </li><li><a href="/search/?q=author%3AShannon%20Weickert%2C%20Cynthia">Shannon Weickert, Cynthia</a>; </li><li><a href="/search/?q=author%3ASmoller%2C%20Jordan%20W">Smoller, Jordan W</a>; </li><li><a href="/search/?q=author%3AStefansson%2C%20Hreinn">Stefansson, Hreinn</a>; </li><li><a href="/search/?q=author%3AStefansson%2C%20Kari">Stefansson, Kari</a>; </li><li><a href="/search/?q=author%3AStordal%2C%20Eystein">Stordal, Eystein</a>; </li><li><a href="/search/?q=author%3AStreit%2C%20Fabian">Streit, Fabian</a>; </li><li><a href="/search/?q=author%3ASullivan%2C%20Patrick%20F">Sullivan, Patrick F</a>; </li><li><a href="/search/?q=author%3ATurecki%2C%20Gustavo">Turecki, Gustavo</a>; </li><li><a href="/search/?q=author%3AVaaler%2C%20Arne%20E">Vaaler, Arne E</a>; </li><li><a href="/search/?q=author%3AVieta%2C%20Eduard">Vieta, Eduard</a>; </li><li><a href="/search/?q=author%3AVincent%2C%20John%20B">Vincent, John B</a>; </li><li><a href="/search/?q=author%3AWaldman%2C%20Irwin%20D">Waldman, Irwin D</a>; </li><li><a href="/search/?q=author%3AWeickert%2C%20Thomas%20W">Weickert, Thomas W</a>; </li><li><a href="/search/?q=author%3AWerge%2C%20Thomas">Werge, Thomas</a>; </li><li><a href="/search/?q=author%3AWray%2C%20Naomi%20R">Wray, Naomi R</a>; </li><li><a href="/search/?q=author%3AZwart%2C%20John-Anker">Zwart, John-Anker</a>; </li><li><a href="/search/?q=author%3ABiernacka%2C%20Joanna%20M">Biernacka, Joanna M</a>; </li><li><a href="/search/?q=author%3ANurnberger%2C%20John%20I">Nurnberger, John I</a>; </li><li><a href="/search/?q=author%3ACichon%2C%20Sven">Cichon, Sven</a>; </li><li><a href="/search/?q=author%3AEdenberg%2C%20Howard%20J">Edenberg, Howard J</a>; </li><li><a href="/search/?q=author%3AStahl%2C%20Eli%20A">Stahl, Eli A</a>; </li><li><a href="/search/?q=author%3AMcQuillin%2C%20Andrew">McQuillin, Andrew</a>; </li><li><a href="/search/?q=author%3ADi%20Florio%2C%20Arianna">Di Florio, Arianna</a>; </li><li><a href="/search/?q=author%3AOphoff%2C%20Roel%20A">Ophoff, Roel A</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3AAndreassen%2C%20Ole%20A">Andreassen, Ole A</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucla_postprints">UCLA Previously Published Works</a> (2021)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup">Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-wide association study of 41,917 bipolar disorder cases and 371,549 controls of European ancestry, which identified 64 associated genomic loci. Bipolar disorder risk alleles were enriched in genes in synaptic signaling pathways and brain-expressed genes, particularly those with high specificity of expression in neurons of the prefrontal cortex and hippocampus. Significant signal enrichment was found in genes encoding targets of antipsychotics, calcium channel blockers, antiepileptics and anesthetics. Integrating expression quantitative trait locus data implicated 15 genes robustly linked to bipolar disorder via gene expression, encoding druggable targets such as HTR6, MCHR1, DCLK3 and FURIN. Analyses of bipolar disorder subtypes indicated high but imperfect genetic correlation between bipolar disorder type I and II and identified additional associated loci. Together, these results advance our understanding of the biological etiology of bipolar disorder, identify novel therapeutic leads and prioritize genes for functional follow-up studies.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/2zn5v9k5"><img src="/cms-assets/74c33e1f3a4bea08906ffa29e9afa2549819c965be56ad5e4c4c3fd8db47b005" alt="Cover page: Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology"/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/96b1p3dw"><div class="c-clientmarkup">Genome-wide association study identifies 30 loci associated with bipolar disorder</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3AStahl%2C%20Eli%20A">Stahl, Eli A</a>; </li><li><a href="/search/?q=author%3ABreen%2C%20Gerome">Breen, Gerome</a>; </li><li><a href="/search/?q=author%3AForstner%2C%20Andreas%20J">Forstner, Andreas J</a>; </li><li><a href="/search/?q=author%3AMcQuillin%2C%20Andrew">McQuillin, Andrew</a>; </li><li><a href="/search/?q=author%3ARipke%2C%20Stephan">Ripke, Stephan</a>; </li><li><a href="/search/?q=author%3ATrubetskoy%2C%20Vassily">Trubetskoy, Vassily</a>; </li><li><a href="/search/?q=author%3AMattheisen%2C%20Manuel">Mattheisen, Manuel</a>; </li><li><a href="/search/?q=author%3AWang%2C%20Yunpeng">Wang, Yunpeng</a>; </li><li><a href="/search/?q=author%3AColeman%2C%20Jonathan%20RI">Coleman, Jonathan RI</a>; </li><li><a href="/search/?q=author%3AGaspar%2C%20H%C3%A9l%C3%A9na%20A">Gaspar, Héléna A</a>; </li><li><a href="/search/?q=author%3Ade%20Leeuw%2C%20Christiaan%20A">de Leeuw, Christiaan A</a>; </li><li><a href="/search/?q=author%3ASteinberg%2C%20Stacy">Steinberg, Stacy</a>; </li><li><a href="/search/?q=author%3APavlides%2C%20Jennifer%20M%20Whitehead">Pavlides, Jennifer M Whitehead</a>; </li><li><a href="/search/?q=author%3ATrzaskowski%2C%20Maciej">Trzaskowski, Maciej</a>; </li><li><a href="/search/?q=author%3AByrne%2C%20Enda%20M">Byrne, Enda M</a>; </li><li><a href="/search/?q=author%3APers%2C%20Tune%20H">Pers, Tune H</a>; </li><li><a href="/search/?q=author%3AHolmans%2C%20Peter%20A">Holmans, Peter A</a>; </li><li><a href="/search/?q=author%3ARichards%2C%20Alexander%20L">Richards, Alexander L</a>; </li><li><a href="/search/?q=author%3AAbbott%2C%20Liam">Abbott, Liam</a>; </li><li><a href="/search/?q=author%3AAgerbo%2C%20Esben">Agerbo, Esben</a>; </li><li><a href="/search/?q=author%3AAkil%2C%20Huda">Akil, Huda</a>; </li><li><a href="/search/?q=author%3AAlbani%2C%20Diego">Albani, Diego</a>; </li><li><a href="/search/?q=author%3AAlliey-Rodriguez%2C%20Ney">Alliey-Rodriguez, Ney</a>; </li><li><a href="/search/?q=author%3AAls%2C%20Thomas%20D">Als, Thomas D</a>; </li><li><a href="/search/?q=author%3AAnjorin%2C%20Adebayo">Anjorin, Adebayo</a>; </li><li><a href="/search/?q=author%3AAntilla%2C%20Verneri">Antilla, Verneri</a>; </li><li><a href="/search/?q=author%3AAwasthi%2C%20Swapnil">Awasthi, Swapnil</a>; </li><li><a href="/search/?q=author%3ABadner%2C%20Judith%20A">Badner, Judith A</a>; </li><li><a href="/search/?q=author%3AB%C3%A6kvad-Hansen%2C%20Marie">Bækvad-Hansen, Marie</a>; </li><li><a href="/search/?q=author%3ABarchas%2C%20Jack%20D">Barchas, Jack D</a>; </li><li><a href="/search/?q=author%3ABass%2C%20Nicholas">Bass, Nicholas</a>; </li><li><a href="/search/?q=author%3ABauer%2C%20Michael">Bauer, Michael</a>; </li><li><a href="/search/?q=author%3ABelliveau%2C%20Richard">Belliveau, Richard</a>; </li><li><a href="/search/?q=author%3ABergen%2C%20Sarah%20E">Bergen, Sarah E</a>; </li><li><a href="/search/?q=author%3APedersen%2C%20Carsten%20B%C3%B8cker">Pedersen, Carsten Bøcker</a>; </li><li><a href="/search/?q=author%3AB%C3%B8en%2C%20Erlend">Bøen, Erlend</a>; </li><li><a href="/search/?q=author%3ABoks%2C%20Marco%20P">Boks, Marco P</a>; </li><li><a href="/search/?q=author%3ABoocock%2C%20James">Boocock, James</a>; </li><li><a href="/search/?q=author%3ABudde%2C%20Monika">Budde, Monika</a>; </li><li><a href="/search/?q=author%3ABunney%2C%20William">Bunney, William</a>; </li><li><a href="/search/?q=author%3ABurmeister%2C%20Margit">Burmeister, Margit</a>; </li><li><a href="/search/?q=author%3ABybjerg-Grauholm%2C%20Jonas">Bybjerg-Grauholm, Jonas</a>; </li><li><a href="/search/?q=author%3AByerley%2C%20William">Byerley, William</a>; </li><li><a href="/search/?q=author%3ACasas%2C%20Miquel">Casas, Miquel</a>; </li><li><a href="/search/?q=author%3ACerrato%2C%20Felecia">Cerrato, Felecia</a>; </li><li><a href="/search/?q=author%3ACervantes%2C%20Pablo">Cervantes, Pablo</a>; </li><li><a href="/search/?q=author%3AChambert%2C%20Kimberly">Chambert, Kimberly</a>; </li><li><a href="/search/?q=author%3ACharney%2C%20Alexander%20W">Charney, Alexander W</a>; </li><li><a href="/search/?q=author%3AChen%2C%20Danfeng">Chen, Danfeng</a>; </li><li><a href="/search/?q=author%3AChurchhouse%2C%20Claire">Churchhouse, Claire</a>; </li><li><a href="/search/?q=author%3AClarke%2C%20Toni-Kim">Clarke, Toni-Kim</a>; </li><li><a href="/search/?q=author%3ACoryell%2C%20William">Coryell, William</a>; </li><li><a href="/search/?q=author%3ACraig%2C%20David%20W">Craig, David W</a>; </li><li><a href="/search/?q=author%3ACruceanu%2C%20Cristiana">Cruceanu, Cristiana</a>; </li><li><a href="/search/?q=author%3ACurtis%2C%20David">Curtis, David</a>; </li><li><a href="/search/?q=author%3ACzerski%2C%20Piotr%20M">Czerski, Piotr M</a>; </li><li><a href="/search/?q=author%3ADale%2C%20Anders%20M">Dale, Anders M</a>; </li><li><a href="/search/?q=author%3Ade%20Jong%2C%20Simone">de Jong, Simone</a>; </li><li><a href="/search/?q=author%3ADegenhardt%2C%20Franziska">Degenhardt, Franziska</a>; </li><li><a href="/search/?q=author%3ADel-Favero%2C%20Jurgen">Del-Favero, Jurgen</a>; </li><li><a href="/search/?q=author%3ADePaulo%2C%20J%20Raymond">DePaulo, J Raymond</a>; </li><li><a href="/search/?q=author%3ADjurovic%2C%20Srdjan">Djurovic, Srdjan</a>; </li><li><a href="/search/?q=author%3ADobbyn%2C%20Amanda%20L">Dobbyn, Amanda L</a>; </li><li><a href="/search/?q=author%3ADumont%2C%20Ashley">Dumont, Ashley</a>; </li><li><a href="/search/?q=author%3AElvs%C3%A5shagen%2C%20Torbj%C3%B8rn">Elvsåshagen, Torbjørn</a>; </li><li><a href="/search/?q=author%3AEscott-Price%2C%20Valentina">Escott-Price, Valentina</a>; </li><li><a href="/search/?q=author%3AFan%2C%20Chun%20Chieh">Fan, Chun Chieh</a>; </li><li><a href="/search/?q=author%3AFischer%2C%20Sascha%20B">Fischer, Sascha B</a>; </li><li><a href="/search/?q=author%3AFlickinger%2C%20Matthew">Flickinger, Matthew</a>; </li><li><a href="/search/?q=author%3AForoud%2C%20Tatiana%20M">Foroud, Tatiana M</a>; </li><li><a href="/search/?q=author%3AForty%2C%20Liz">Forty, Liz</a>; </li><li><a href="/search/?q=author%3AFrank%2C%20Josef">Frank, Josef</a>; </li><li><a href="/search/?q=author%3AFraser%2C%20Christine">Fraser, Christine</a>; </li><li><a href="/search/?q=author%3AFreimer%2C%20Nelson%20B">Freimer, Nelson B</a>; </li><li><a href="/search/?q=author%3AFris%C3%A9n%2C%20Louise">Frisén, Louise</a>; </li><li><a href="/search/?q=author%3AGade%2C%20Katrin">Gade, Katrin</a>; </li><li><a href="/search/?q=author%3AGage%2C%20Diane">Gage, Diane</a>; </li><li><a href="/search/?q=author%3AGarnham%2C%20Julie">Garnham, Julie</a>; </li><li><a href="/search/?q=author%3AGiambartolomei%2C%20Claudia">Giambartolomei, Claudia</a>; </li><li><a href="/search/?q=author%3APedersen%2C%20Marianne%20Gi%C3%B8rtz">Pedersen, Marianne Giørtz</a>; </li><li><a href="/search/?q=author%3AGoldstein%2C%20Jaqueline">Goldstein, Jaqueline</a>; </li><li><a href="/search/?q=author%3AGordon%2C%20Scott%20D">Gordon, Scott D</a>; </li><li><a href="/search/?q=author%3AGordon-Smith%2C%20Katherine">Gordon-Smith, Katherine</a>; </li><li><a href="/search/?q=author%3AGreen%2C%20Elaine%20K">Green, Elaine K</a>; </li><li><a href="/search/?q=author%3AGreen%2C%20Melissa%20J">Green, Melissa J</a>; </li><li><a href="/search/?q=author%3AGreenwood%2C%20Tiffany%20A">Greenwood, Tiffany A</a>; </li><li><a href="/search/?q=author%3AGrove%2C%20Jakob">Grove, Jakob</a>; </li><li><a href="/search/?q=author%3AGuan%2C%20Weihua">Guan, Weihua</a>; </li><li><a href="/search/?q=author%3AGuzman-Parra%2C%20Jos%C3%A9">Guzman-Parra, José</a>; </li><li><a href="/search/?q=author%3AHamshere%2C%20Marian%20L">Hamshere, Marian L</a>; </li><li><a href="/search/?q=author%3AHautzinger%2C%20Martin">Hautzinger, Martin</a>; </li><li><a href="/search/?q=author%3AHeilbronner%2C%20Urs">Heilbronner, Urs</a>; </li><li><a href="/search/?q=author%3AHerms%2C%20Stefan">Herms, Stefan</a>; </li><li><a href="/search/?q=author%3AHipolito%2C%20Maria">Hipolito, Maria</a>; </li><li><a href="/search/?q=author%3AHoffmann%2C%20Per">Hoffmann, Per</a>; </li><li><a href="/search/?q=author%3AHolland%2C%20Dominic">Holland, Dominic</a>; </li><li><a href="/search/?q=author%3AHuckins%2C%20Laura">Huckins, Laura</a>; </li><li><a href="/search/?q=author%3AJamain%2C%20St%C3%A9phane">Jamain, Stéphane</a>; </li><li><a href="/search/?q=author%3AJohnson%2C%20Jessica%20S">Johnson, Jessica S</a>; </li><li><a href="/search/?q=author%3AJur%C3%A9us%2C%20Anders">Juréus, Anders</a>; </li><li><a href="/search/?q=author%3AKandaswamy%2C%20Radhika">Kandaswamy, Radhika</a>; </li><li><a href="/search/?q=author%3AKarlsson%2C%20Robert">Karlsson, Robert</a>; </li><li><a href="/search/?q=author%3AKennedy%2C%20James%20L">Kennedy, James L</a>; </li><li><a href="/search/?q=author%3AKittel-Schneider%2C%20Sarah">Kittel-Schneider, Sarah</a>; </li><li><a href="/search/?q=author%3AKnowles%2C%20James%20A">Knowles, James A</a>; </li><li><a href="/search/?q=author%3AKogevinas%2C%20Manolis">Kogevinas, Manolis</a>; </li><li><a href="/search/?q=author%3AKoller%2C%20Anna%20C">Koller, Anna C</a>; </li><li><a href="/search/?q=author%3AKupka%2C%20Ralph">Kupka, Ralph</a>; </li><li><a href="/search/?q=author%3ALavebratt%2C%20Catharina">Lavebratt, Catharina</a>; </li><li><a href="/search/?q=author%3ALawrence%2C%20Jacob">Lawrence, Jacob</a>; </li><li><a href="/search/?q=author%3ALawson%2C%20William%20B">Lawson, William B</a>; </li><li><a href="/search/?q=author%3ALeber%2C%20Markus">Leber, Markus</a>; </li><li><a href="/search/?q=author%3ALee%2C%20Phil%20H">Lee, Phil H</a>; </li><li><a href="/search/?q=author%3ALevy%2C%20Shawn%20E">Levy, Shawn E</a>; </li><li><a href="/search/?q=author%3ALi%2C%20Jun%20Z">Li, Jun Z</a>; </li><li><a href="/search/?q=author%3ALiu%2C%20Chunyu">Liu, Chunyu</a>; </li><li><a href="/search/?q=author%3ALucae%2C%20Susanne">Lucae, Susanne</a>; </li><li><a href="/search/?q=author%3AMaaser%2C%20Anna">Maaser, Anna</a>; </li><li><a href="/search/?q=author%3AMacIntyre%2C%20Donald%20J">MacIntyre, Donald J</a>; </li><li><a href="/search/?q=author%3AMahon%2C%20Pamela%20B">Mahon, Pamela B</a>; </li><li><a href="/search/?q=author%3AMaier%2C%20Wolfgang">Maier, Wolfgang</a>; </li><li><a href="/search/?q=author%3AMartinsson%2C%20Lina">Martinsson, Lina</a>; </li><li><a href="/search/?q=author%3AMcCarroll%2C%20Steve">McCarroll, Steve</a>; </li><li><a href="/search/?q=author%3AMcGuffin%2C%20Peter">McGuffin, Peter</a>; </li><li><a href="/search/?q=author%3AMcInnis%2C%20Melvin%20G">McInnis, Melvin G</a>; </li><li><a href="/search/?q=author%3AMcKay%2C%20James%20D">McKay, James D</a>; </li><li><a href="/search/?q=author%3AMedeiros%2C%20Helena">Medeiros, Helena</a>; </li><li><a href="/search/?q=author%3AMedland%2C%20Sarah%20E">Medland, Sarah E</a>; </li><li><a href="/search/?q=author%3AMeng%2C%20Fan">Meng, Fan</a>; </li><li><a href="/search/?q=author%3AMilani%2C%20Lili">Milani, Lili</a>; </li><li><a href="/search/?q=author%3AMontgomery%2C%20Grant%20W">Montgomery, Grant W</a>; </li><li><a href="/search/?q=author%3AMorris%2C%20Derek%20W">Morris, Derek W</a>; </li><li><a href="/search/?q=author%3AM%C3%BChleisen%2C%20Thomas%20W">Mühleisen, Thomas W</a>; </li><li><a href="/search/?q=author%3AMullins%2C%20Niamh">Mullins, Niamh</a>; </li><li><a href="/search/?q=author%3ANguyen%2C%20Hoang">Nguyen, Hoang</a>; </li><li><a href="/search/?q=author%3ANievergelt%2C%20Caroline%20M">Nievergelt, Caroline M</a>; </li><li><a href="/search/?q=author%3AAdolfsson%2C%20Annelie%20Nordin">Adolfsson, Annelie Nordin</a>; </li><li><a href="/search/?q=author%3ANwulia%2C%20Evaristus%20A">Nwulia, Evaristus A</a>; </li><li><a href="/search/?q=author%3AO%E2%80%99Donovan%2C%20Claire">O’Donovan, Claire</a>; </li><li><a href="/search/?q=author%3ALoohuis%2C%20Loes%20M%20Olde">Loohuis, Loes M Olde</a>; </li><li><a href="/search/?q=author%3AOri%2C%20Anil%20PS">Ori, Anil PS</a>; </li><li><a href="/search/?q=author%3AOruc%2C%20Lilijana">Oruc, Lilijana</a>; </li><li><a href="/search/?q=author%3A%C3%96sby%2C%20Urban">Ösby, Urban</a>; </li><li><a href="/search/?q=author%3APerlis%2C%20Roy%20H">Perlis, Roy H</a>; </li><li><a href="/search/?q=author%3APerry%2C%20Amy">Perry, Amy</a>; </li><li><a href="/search/?q=author%3APfennig%2C%20Andrea">Pfennig, Andrea</a>; </li><li><a href="/search/?q=author%3APotash%2C%20James%20B">Potash, James B</a>; </li><li><a href="/search/?q=author%3APurcell%2C%20Shaun%20M">Purcell, Shaun M</a>; </li><li><a href="/search/?q=author%3ARegeer%2C%20Eline%20J">Regeer, Eline J</a>; </li><li><a href="/search/?q=author%3AReif%2C%20Andreas">Reif, Andreas</a>; </li><li><a href="/search/?q=author%3AReinbold%2C%20C%C3%A9line%20S">Reinbold, Céline S</a>; </li><li><a href="/search/?q=author%3ARice%2C%20John%20P">Rice, John P</a>; </li><li><a href="/search/?q=author%3ARivas%2C%20Fabio">Rivas, Fabio</a>; </li><li><a href="/search/?q=author%3ARivera%2C%20Margarita">Rivera, Margarita</a>; </li><li><a href="/search/?q=author%3ARoussos%2C%20Panos">Roussos, Panos</a>; </li><li><a href="/search/?q=author%3ARuderfer%2C%20Douglas%20M">Ruderfer, Douglas M</a>; </li><li><a href="/search/?q=author%3ARyu%2C%20Euijung">Ryu, Euijung</a>; </li><li><a href="/search/?q=author%3AS%C3%A1nchez-Mora%2C%20Cristina">Sánchez-Mora, Cristina</a>; </li><li><a href="/search/?q=author%3ASchatzberg%2C%20Alan%20F">Schatzberg, Alan F</a>; </li><li><a href="/search/?q=author%3AScheftner%2C%20William%20A">Scheftner, William A</a>; </li><li><a href="/search/?q=author%3ASchork%2C%20Nicholas%20J">Schork, Nicholas J</a>; </li><li><a href="/search/?q=author%3AShannon%20Weickert%2C%20Cynthia">Shannon Weickert, Cynthia</a>; </li><li><a href="/search/?q=author%3AShehktman%2C%20Tatyana">Shehktman, Tatyana</a>; </li><li><a href="/search/?q=author%3AShilling%2C%20Paul%20D">Shilling, Paul D</a>; </li><li><a href="/search/?q=author%3ASigurdsson%2C%20Engilbert">Sigurdsson, Engilbert</a>; </li><li><a href="/search/?q=author%3ASlaney%2C%20Claire">Slaney, Claire</a>; </li><li><a href="/search/?q=author%3ASmeland%2C%20Olav%20B">Smeland, Olav B</a>; </li><li><a href="/search/?q=author%3ASobell%2C%20Janet%20L">Sobell, Janet L</a>; </li><li><a href="/search/?q=author%3AS%C3%B8holm%20Hansen%2C%20Christine">Søholm Hansen, Christine</a>; </li><li><a href="/search/?q=author%3ASpijker%2C%20Anne%20T">Spijker, Anne T</a>; </li><li><a href="/search/?q=author%3ASt%20Clair%2C%20David">St Clair, David</a>; </li><li><a href="/search/?q=author%3ASteffens%2C%20Michael">Steffens, Michael</a>; </li><li><a href="/search/?q=author%3AStrauss%2C%20John%20S">Strauss, John S</a>; </li><li><a href="/search/?q=author%3AStreit%2C%20Fabian">Streit, Fabian</a>; </li><li><a href="/search/?q=author%3AStrohmaier%2C%20Jana">Strohmaier, Jana</a>; </li><li><a href="/search/?q=author%3ASzelinger%2C%20Szabolcs">Szelinger, Szabolcs</a>; </li><li><a href="/search/?q=author%3AThompson%2C%20Robert%20C">Thompson, Robert C</a>; </li><li><a href="/search/?q=author%3AThorgeirsson%2C%20Thorgeir%20E">Thorgeirsson, Thorgeir E</a>; </li><li><a href="/search/?q=author%3ATreutlein%2C%20Jens">Treutlein, Jens</a>; </li><li><a href="/search/?q=author%3AVedder%2C%20Helmut">Vedder, Helmut</a>; </li><li><a href="/search/?q=author%3AWang%2C%20Weiqing">Wang, Weiqing</a>; </li><li><a href="/search/?q=author%3AWatson%2C%20Stanley%20J">Watson, Stanley J</a>; </li><li><a href="/search/?q=author%3AWeickert%2C%20Thomas%20W">Weickert, Thomas W</a>; </li><li><a href="/search/?q=author%3AWitt%2C%20Stephanie%20H">Witt, Stephanie H</a>; </li><li><a href="/search/?q=author%3AXi%2C%20Simon">Xi, Simon</a>; </li><li><a href="/search/?q=author%3AXu%2C%20Wei">Xu, Wei</a>; </li><li><a href="/search/?q=author%3AYoung%2C%20Allan%20H">Young, Allan H</a>; </li><li><a href="/search/?q=author%3AZandi%2C%20Peter">Zandi, Peter</a>; </li><li><a href="/search/?q=author%3AZhang%2C%20Peng">Zhang, Peng</a>; </li><li><a href="/search/?q=author%3AZ%C3%B6llner%2C%20Sebastian">Zöllner, Sebastian</a>; </li><li><a href="/search/?q=author%3AAdolfsson%2C%20Rolf">Adolfsson, Rolf</a>; </li><li><a href="/search/?q=author%3AAgartz%2C%20Ingrid">Agartz, Ingrid</a>; </li><li><a href="/search/?q=author%3AAlda%2C%20Martin">Alda, Martin</a>; </li><li><a href="/search/?q=author%3ABacklund%2C%20Lena">Backlund, Lena</a>; </li><li><a href="/search/?q=author%3ABaune%2C%20Bernhard%20T">Baune, Bernhard T</a>; </li><li><a href="/search/?q=author%3ABellivier%2C%20Frank">Bellivier, Frank</a>; </li><li><a href="/search/?q=author%3ABerrettini%2C%20Wade%20H">Berrettini, Wade H</a>; </li><li><a href="/search/?q=author%3ABiernacka%2C%20Joanna%20M">Biernacka, Joanna M</a>; </li><li><a href="/search/?q=author%3ABlackwood%2C%20Douglas%20HR">Blackwood, Douglas HR</a>; </li><li><a href="/search/?q=author%3ABoehnke%2C%20Michael">Boehnke, Michael</a>; </li><li><a href="/search/?q=author%3AB%C3%B8rglum%2C%20Anders%20D">Børglum, Anders D</a>; </li><li><a href="/search/?q=author%3ACorvin%2C%20Aiden">Corvin, Aiden</a>; </li><li><a href="/search/?q=author%3ACraddock%2C%20Nicholas">Craddock, Nicholas</a>; </li><li><a href="/search/?q=author%3ADaly%2C%20Mark%20J">Daly, Mark J</a>; </li><li><a href="/search/?q=author%3ADannlowski%2C%20Udo">Dannlowski, Udo</a>; </li><li><a href="/search/?q=author%3AEsko%2C%20T%C3%B5nu">Esko, Tõnu</a>; </li><li><a href="/search/?q=author%3AEtain%2C%20Bruno">Etain, Bruno</a>; </li><li><a href="/search/?q=author%3AFrye%2C%20Mark">Frye, Mark</a>; </li><li><a href="/search/?q=author%3AFullerton%2C%20Janice%20M">Fullerton, Janice M</a>; </li><li><a href="/search/?q=author%3AGershon%2C%20Elliot%20S">Gershon, Elliot S</a>; </li><li><a href="/search/?q=author%3AGill%2C%20Michael">Gill, Michael</a>; </li><li><a href="/search/?q=author%3AGoes%2C%20Fernando">Goes, Fernando</a>; </li><li><a href="/search/?q=author%3AGrigoroiu-Serbanescu%2C%20Maria">Grigoroiu-Serbanescu, Maria</a>; </li><li><a href="/search/?q=author%3AHauser%2C%20Joanna">Hauser, Joanna</a>; </li><li><a href="/search/?q=author%3AHougaard%2C%20David%20M">Hougaard, David M</a>; </li><li><a href="/search/?q=author%3AHultman%2C%20Christina%20M">Hultman, Christina M</a>; </li><li><a href="/search/?q=author%3AJones%2C%20Ian">Jones, Ian</a>; </li><li><a href="/search/?q=author%3AJones%2C%20Lisa%20A">Jones, Lisa A</a>; </li><li><a href="/search/?q=author%3AKahn%2C%20Ren%C3%A9%20S">Kahn, René S</a>; </li><li><a href="/search/?q=author%3AKirov%2C%20George">Kirov, George</a>; </li><li><a href="/search/?q=author%3ALand%C3%A9n%2C%20Mikael">Landén, Mikael</a>; </li><li><a href="/search/?q=author%3ALeboyer%2C%20Marion">Leboyer, Marion</a>; </li><li><a href="/search/?q=author%3ALewis%2C%20Cathryn%20M">Lewis, Cathryn M</a>; </li><li><a href="/search/?q=author%3ALi%2C%20Qingqin%20S">Li, Qingqin S</a>; </li><li><a href="/search/?q=author%3ALissowska%2C%20Jolanta">Lissowska, Jolanta</a>; </li><li><a href="/search/?q=author%3AMartin%2C%20Nicholas%20G">Martin, Nicholas G</a>; </li><li><a href="/search/?q=author%3AMayoral%2C%20Fermin">Mayoral, Fermin</a>; </li><li><a href="/search/?q=author%3AMcElroy%2C%20Susan%20L">McElroy, Susan L</a>; </li><li><a href="/search/?q=author%3AMcIntosh%2C%20Andrew%20M">McIntosh, Andrew M</a>; </li><li><a href="/search/?q=author%3AMcMahon%2C%20Francis%20J">McMahon, Francis J</a>; </li><li><a href="/search/?q=author%3AMelle%2C%20Ingrid">Melle, Ingrid</a>; </li><li><a href="/search/?q=author%3AMetspalu%2C%20Andres">Metspalu, Andres</a>; </li><li><a href="/search/?q=author%3AMitchell%2C%20Philip%20B">Mitchell, Philip B</a>; </li><li><a href="/search/?q=author%3AMorken%2C%20Gunnar">Morken, Gunnar</a>; </li><li><a href="/search/?q=author%3AMors%2C%20Ole">Mors, Ole</a>; </li><li><a href="/search/?q=author%3AMortensen%2C%20Preben%20Bo">Mortensen, Preben Bo</a>; </li><li><a href="/search/?q=author%3AM%C3%BCller-Myhsok%2C%20Bertram">Müller-Myhsok, Bertram</a>; </li><li><a href="/search/?q=author%3AMyers%2C%20Richard%20M">Myers, Richard M</a>; </li><li><a href="/search/?q=author%3ANeale%2C%20Benjamin%20M">Neale, Benjamin M</a>; </li><li><a href="/search/?q=author%3ANimgaonkar%2C%20Vishwajit">Nimgaonkar, Vishwajit</a>; </li><li><a href="/search/?q=author%3ANordentoft%2C%20Merete">Nordentoft, Merete</a>; </li><li><a href="/search/?q=author%3AN%C3%B6then%2C%20Markus%20M">Nöthen, Markus M</a>; </li><li><a href="/search/?q=author%3AO%E2%80%99Donovan%2C%20Michael%20C">O’Donovan, Michael C</a>; </li><li><a href="/search/?q=author%3AOedegaard%2C%20Ketil%20J">Oedegaard, Ketil J</a>; </li><li><a href="/search/?q=author%3AOwen%2C%20Michael%20J">Owen, Michael J</a>; </li><li><a href="/search/?q=author%3APaciga%2C%20Sara%20A">Paciga, Sara A</a>; </li><li><a href="/search/?q=author%3APato%2C%20Carlos">Pato, Carlos</a>; </li><li><a href="/search/?q=author%3APato%2C%20Michele%20T">Pato, Michele T</a>; </li><li><a href="/search/?q=author%3APosthuma%2C%20Danielle">Posthuma, Danielle</a>; </li><li><a href="/search/?q=author%3ARamos-Quiroga%2C%20Josep%20Antoni">Ramos-Quiroga, Josep Antoni</a>; </li><li><a href="/search/?q=author%3ARibas%C3%A9s%2C%20Marta">Ribasés, Marta</a>; </li><li><a href="/search/?q=author%3ARietschel%2C%20Marcella">Rietschel, Marcella</a>; </li><li><a href="/search/?q=author%3ARouleau%2C%20Guy%20A">Rouleau, Guy A</a>; </li><li><a href="/search/?q=author%3ASchalling%2C%20Martin">Schalling, Martin</a>; </li><li><a href="/search/?q=author%3ASchofield%2C%20Peter%20R">Schofield, Peter R</a>; </li><li><a href="/search/?q=author%3ASchulze%2C%20Thomas%20G">Schulze, Thomas G</a>; </li><li><a href="/search/?q=author%3ASerretti%2C%20Alessandro">Serretti, Alessandro</a>; </li><li><a href="/search/?q=author%3ASmoller%2C%20Jordan%20W">Smoller, Jordan W</a>; </li><li><a href="/search/?q=author%3AStefansson%2C%20Hreinn">Stefansson, Hreinn</a>; </li><li><a href="/search/?q=author%3AStefansson%2C%20Kari">Stefansson, Kari</a>; </li><li><a href="/search/?q=author%3AStordal%2C%20Eystein">Stordal, Eystein</a>; </li><li><a href="/search/?q=author%3ASullivan%2C%20Patrick%20F">Sullivan, Patrick F</a>; </li><li><a href="/search/?q=author%3ATurecki%2C%20Gustavo">Turecki, Gustavo</a>; </li><li><a href="/search/?q=author%3AVaaler%2C%20Arne%20E">Vaaler, Arne E</a>; </li><li><a href="/search/?q=author%3AVieta%2C%20Eduard">Vieta, Eduard</a>; </li><li><a href="/search/?q=author%3AVincent%2C%20John%20B">Vincent, John B</a>; </li><li><a href="/search/?q=author%3AWerge%2C%20Thomas">Werge, Thomas</a>; </li><li><a href="/search/?q=author%3ANurnberger%2C%20John%20I">Nurnberger, John I</a>; </li><li><a href="/search/?q=author%3AWray%2C%20Naomi%20R">Wray, Naomi R</a>; </li><li><a href="/search/?q=author%3ADi%20Florio%2C%20Arianna">Di Florio, Arianna</a>; </li><li><a href="/search/?q=author%3AEdenberg%2C%20Howard%20J">Edenberg, Howard J</a>; </li><li><a href="/search/?q=author%3ACichon%2C%20Sven">Cichon, Sven</a>; </li><li><a href="/search/?q=author%3AOphoff%2C%20Roel%20A">Ophoff, Roel A</a>; </li><li><a href="/search/?q=author%3AScott%2C%20Laura%20J">Scott, Laura J</a>; </li><li><a href="/search/?q=author%3AAndreassen%2C%20Ole%20A">Andreassen, Ole A</a>; </li><li><a href="/search/?q=author%3AKelsoe%2C%20John">Kelsoe, John</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3ASklar%2C%20Pamela">Sklar, Pamela</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucla_postprints">UCLA Previously Published Works</a> (2019)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup">Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide association study (GWAS) including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 variants with P < 1 × 10<sup>-4</sup> in an additional 9,412 cases and 137,760 controls. Eight of the 19 variants that were genome-wide significant (P < 5 × 10<sup>-8</sup>) in the discovery GWAS were not genome-wide significant in the combined analysis, consistent with small effect sizes and limited power but also with genetic heterogeneity. In the combined analysis, 30 loci were genome-wide significant, including 20 newly identified loci. The significant loci contain genes encoding ion channels, neurotransmitter transporters and synaptic components. Pathway analysis revealed nine significantly enriched gene sets, including regulation of insulin secretion and endocannabinoid signaling. Bipolar I disorder is strongly genetically correlated with schizophrenia, driven by psychosis, whereas bipolar II disorder is more strongly correlated with major depressive disorder. These findings address key clinical questions and provide potential biological mechanisms for bipolar disorder.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/96b1p3dw"><img src="/cms-assets/d9faee969c033f51318f3b1f365de09e0449ae467a9cb8b971eb5c1fe6182056" alt="Cover page: Genome-wide association study identifies 30 loci associated with bipolar disorder"/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/8jn2p3sp"><div class="c-clientmarkup">Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors.</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3AMullins%2C%20Niamh">Mullins, Niamh</a>; </li><li><a href="/search/?q=author%3AKang%2C%20JooEun">Kang, JooEun</a>; </li><li><a href="/search/?q=author%3ACampos%2C%20Adrian%20I">Campos, Adrian I</a>; </li><li><a href="/search/?q=author%3AColeman%2C%20Jonathan%20RI">Coleman, Jonathan RI</a>; </li><li><a href="/search/?q=author%3AEdwards%2C%20Alexis%20C">Edwards, Alexis C</a>; </li><li><a href="/search/?q=author%3AGalfalvy%2C%20Hanga">Galfalvy, Hanga</a>; </li><li><a href="/search/?q=author%3ALevey%2C%20Daniel%20F">Levey, Daniel F</a>; </li><li><a href="/search/?q=author%3ALori%2C%20Adriana">Lori, Adriana</a>; </li><li><a href="/search/?q=author%3AShabalin%2C%20Andrey">Shabalin, Andrey</a>; </li><li><a href="/search/?q=author%3AStarnawska%2C%20Anna">Starnawska, Anna</a>; </li><li><a href="/search/?q=author%3ASu%2C%20Mei-Hsin">Su, Mei-Hsin</a>; </li><li><a href="/search/?q=author%3AWatson%2C%20Hunna%20J">Watson, Hunna J</a>; </li><li><a href="/search/?q=author%3AAdams%2C%20Mark">Adams, Mark</a>; </li><li><a href="/search/?q=author%3AAwasthi%2C%20Swapnil">Awasthi, Swapnil</a>; </li><li><a href="/search/?q=author%3AGandal%2C%20Michael">Gandal, Michael</a>; </li><li><a href="/search/?q=author%3AHafferty%2C%20Jonathan%20D">Hafferty, Jonathan D</a>; </li><li><a href="/search/?q=author%3AHishimoto%2C%20Akitoyo">Hishimoto, Akitoyo</a>; </li><li><a href="/search/?q=author%3AKim%2C%20Minsoo">Kim, Minsoo</a>; </li><li><a href="/search/?q=author%3AOkazaki%2C%20Satoshi">Okazaki, Satoshi</a>; </li><li><a href="/search/?q=author%3AOtsuka%2C%20Ikuo">Otsuka, Ikuo</a>; </li><li><a href="/search/?q=author%3ARipke%2C%20Stephan">Ripke, Stephan</a>; </li><li><a href="/search/?q=author%3AWare%2C%20Erin%20B">Ware, Erin B</a>; </li><li><a href="/search/?q=author%3ABergen%2C%20Andrew%20W">Bergen, Andrew W</a>; </li><li><a href="/search/?q=author%3ABerrettini%2C%20Wade%20H">Berrettini, Wade H</a>; </li><li><a href="/search/?q=author%3ABohus%2C%20Martin">Bohus, Martin</a>; </li><li><a href="/search/?q=author%3ABrandt%2C%20Harry">Brandt, Harry</a>; </li><li><a href="/search/?q=author%3AChang%2C%20Xiao">Chang, Xiao</a>; </li><li><a href="/search/?q=author%3AChen%2C%20Wei%20J">Chen, Wei J</a>; </li><li><a href="/search/?q=author%3AChen%2C%20Hsi-Chung">Chen, Hsi-Chung</a>; </li><li><a href="/search/?q=author%3ACrawford%2C%20Steven">Crawford, Steven</a>; </li><li><a href="/search/?q=author%3ACrow%2C%20Scott">Crow, Scott</a>; </li><li><a href="/search/?q=author%3ADiBlasi%2C%20Emily">DiBlasi, Emily</a>; </li><li><a href="/search/?q=author%3ADuriez%2C%20Philibert">Duriez, Philibert</a>; </li><li><a href="/search/?q=author%3AFern%C3%A1ndez-Aranda%2C%20Fernando">Fernández-Aranda, Fernando</a>; </li><li><a href="/search/?q=author%3AFichter%2C%20Manfred%20M">Fichter, Manfred M</a>; </li><li><a href="/search/?q=author%3AGallinger%2C%20Steven">Gallinger, Steven</a>; </li><li><a href="/search/?q=author%3AGlatt%2C%20Stephen%20J">Glatt, Stephen J</a>; </li><li><a href="/search/?q=author%3AGorwood%2C%20Philip">Gorwood, Philip</a>; </li><li><a href="/search/?q=author%3AGuo%2C%20Yiran">Guo, Yiran</a>; </li><li><a href="/search/?q=author%3AHakonarson%2C%20Hakon">Hakonarson, Hakon</a>; </li><li><a href="/search/?q=author%3AHalmi%2C%20Katherine%20A">Halmi, Katherine A</a>; </li><li><a href="/search/?q=author%3AHwu%2C%20Hai-Gwo">Hwu, Hai-Gwo</a>; </li><li><a href="/search/?q=author%3AJain%2C%20Sonia">Jain, Sonia</a>; </li><li><a href="/search/?q=author%3AJamain%2C%20St%C3%A9phane">Jamain, Stéphane</a>; </li><li><a href="/search/?q=author%3AJim%C3%A9nez-Murcia%2C%20Susana">Jiménez-Murcia, Susana</a>; </li><li><a href="/search/?q=author%3AJohnson%2C%20Craig">Johnson, Craig</a>; </li><li><a href="/search/?q=author%3AKaplan%2C%20Allan%20S">Kaplan, Allan S</a>; </li><li><a href="/search/?q=author%3AKaye%2C%20Walter%20H">Kaye, Walter H</a>; </li><li><a href="/search/?q=author%3AKeel%2C%20Pamela%20K">Keel, Pamela K</a>; </li><li><a href="/search/?q=author%3AKennedy%2C%20James%20L">Kennedy, James L</a>; </li><li><a href="/search/?q=author%3AKlump%2C%20Kelly%20L">Klump, Kelly L</a>; </li><li><a href="/search/?q=author%3ALi%2C%20Dong">Li, Dong</a>; </li><li><a href="/search/?q=author%3ALiao%2C%20Shih-Cheng">Liao, Shih-Cheng</a>; </li><li><a href="/search/?q=author%3ALieb%2C%20Klaus">Lieb, Klaus</a>; </li><li><a href="/search/?q=author%3ALilenfeld%2C%20Lisa">Lilenfeld, Lisa</a>; </li><li><a href="/search/?q=author%3ALiu%2C%20Chih-Min">Liu, Chih-Min</a>; </li><li><a href="/search/?q=author%3AMagistretti%2C%20Pierre%20J">Magistretti, Pierre J</a>; </li><li><a href="/search/?q=author%3AMarshall%2C%20Christian%20R">Marshall, Christian R</a>; </li><li><a href="/search/?q=author%3AMitchell%2C%20James%20E">Mitchell, James E</a>; </li><li><a href="/search/?q=author%3AMonson%2C%20Eric%20T">Monson, Eric T</a>; </li><li><a href="/search/?q=author%3AMyers%2C%20Richard%20M">Myers, Richard M</a>; </li><li><a href="/search/?q=author%3APinto%2C%20Dalila">Pinto, Dalila</a>; </li><li><a href="/search/?q=author%3APowers%2C%20Abigail">Powers, Abigail</a>; </li><li><a href="/search/?q=author%3ARamoz%2C%20Nicolas">Ramoz, Nicolas</a>; </li><li><a href="/search/?q=author%3ARoepke%2C%20Stefan">Roepke, Stefan</a>; </li><li><a href="/search/?q=author%3ARozanov%2C%20Vsevolod">Rozanov, Vsevolod</a>; </li><li><a href="/search/?q=author%3AScherer%2C%20Stephen%20W">Scherer, Stephen W</a>; </li><li><a href="/search/?q=author%3ASchmahl%2C%20Christian">Schmahl, Christian</a>; </li><li><a href="/search/?q=author%3ASokolowski%2C%20Marcus">Sokolowski, Marcus</a>; </li><li><a href="/search/?q=author%3AStrober%2C%20Michael">Strober, Michael</a>; </li><li><a href="/search/?q=author%3AThornton%2C%20Laura%20M">Thornton, Laura M</a>; </li><li><a href="/search/?q=author%3ATreasure%2C%20Janet">Treasure, Janet</a>; </li><li><a href="/search/?q=author%3ATsuang%2C%20Ming%20T">Tsuang, Ming T</a>; </li><li><a href="/search/?q=author%3AWitt%2C%20Stephanie%20H">Witt, Stephanie H</a>; </li><li><a href="/search/?q=author%3AWoodside%2C%20D%20Blake">Woodside, D Blake</a>; </li><li><a href="/search/?q=author%3AYilmaz%2C%20Zeynep">Yilmaz, Zeynep</a>; </li><li><a href="/search/?q=author%3AZillich%2C%20Lea">Zillich, Lea</a>; </li><li><a href="/search/?q=author%3AAdolfsson%2C%20Rolf">Adolfsson, Rolf</a>; </li><li><a href="/search/?q=author%3AAgartz%2C%20Ingrid">Agartz, Ingrid</a>; </li><li><a href="/search/?q=author%3AAir%2C%20Tracy%20M">Air, Tracy M</a>; </li><li><a href="/search/?q=author%3AAlda%2C%20Martin">Alda, Martin</a>; </li><li><a href="/search/?q=author%3AAlfredsson%2C%20Lars">Alfredsson, Lars</a>; </li><li><a href="/search/?q=author%3AAndreassen%2C%20Ole%20A">Andreassen, Ole A</a>; </li><li><a href="/search/?q=author%3AAnjorin%2C%20Adebayo">Anjorin, Adebayo</a>; </li><li><a href="/search/?q=author%3AAppadurai%2C%20Vivek">Appadurai, Vivek</a>; </li><li><a href="/search/?q=author%3ASoler%20Artigas%2C%20Mar%C3%ADa">Soler Artigas, María</a>; </li><li><a href="/search/?q=author%3AVan%20der%20Auwera%2C%20Sandra">Van der Auwera, Sandra</a>; </li><li><a href="/search/?q=author%3AAzevedo%2C%20M%20Helena">Azevedo, M Helena</a>; </li><li><a href="/search/?q=author%3ABass%2C%20Nicholas">Bass, Nicholas</a>; </li><li><a href="/search/?q=author%3ABau%2C%20Claiton%20HD">Bau, Claiton HD</a>; </li><li><a href="/search/?q=author%3ABaune%2C%20Bernhard%20T">Baune, Bernhard T</a>; </li><li><a href="/search/?q=author%3ABellivier%2C%20Frank">Bellivier, Frank</a>; </li><li><a href="/search/?q=author%3ABerger%2C%20Klaus">Berger, Klaus</a>; </li><li><a href="/search/?q=author%3ABiernacka%2C%20Joanna%20M">Biernacka, Joanna M</a>; </li><li><a href="/search/?q=author%3ABigdeli%2C%20Tim%20B">Bigdeli, Tim B</a>; </li><li><a href="/search/?q=author%3ABinder%2C%20Elisabeth%20B">Binder, Elisabeth B</a>; </li><li><a href="/search/?q=author%3ABoehnke%2C%20Michael">Boehnke, Michael</a>; </li><li><a href="/search/?q=author%3ABoks%2C%20Marco%20P">Boks, Marco P</a>; </li><li><a href="/search/?q=author%3ABosch%2C%20Rosa">Bosch, Rosa</a>; </li><li><a href="/search/?q=author%3ABraff%2C%20David%20L">Braff, David L</a>; </li><li><a href="/search/?q=author%3ABryant%2C%20Richard">Bryant, Richard</a>; </li><li><a href="/search/?q=author%3ABudde%2C%20Monika">Budde, Monika</a>; </li><li><a href="/search/?q=author%3AByrne%2C%20Enda%20M">Byrne, Enda M</a>; </li><li><a href="/search/?q=author%3ACahn%2C%20Wiepke">Cahn, Wiepke</a>; </li><li><a href="/search/?q=author%3ACasas%2C%20Miguel">Casas, Miguel</a>; </li><li><a href="/search/?q=author%3ACastelao%2C%20Enrique">Castelao, Enrique</a>; </li><li><a href="/search/?q=author%3ACervilla%2C%20Jorge%20A">Cervilla, Jorge A</a>; </li><li><a href="/search/?q=author%3AChaumette%2C%20Boris">Chaumette, Boris</a>; </li><li><a href="/search/?q=author%3ACichon%2C%20Sven">Cichon, Sven</a>; </li><li><a href="/search/?q=author%3ACorvin%2C%20Aiden">Corvin, Aiden</a>; </li><li><a href="/search/?q=author%3ACraddock%2C%20Nicholas">Craddock, Nicholas</a>; </li><li><a href="/search/?q=author%3ACraig%2C%20David">Craig, David</a>; </li><li><a href="/search/?q=author%3ADegenhardt%2C%20Franziska">Degenhardt, Franziska</a>; </li><li><a href="/search/?q=author%3ADjurovic%2C%20Srdjan">Djurovic, Srdjan</a>; </li><li><a href="/search/?q=author%3AEdenberg%2C%20Howard%20J">Edenberg, Howard J</a>; </li><li><a href="/search/?q=author%3AFanous%2C%20Ayman%20H">Fanous, Ayman H</a>; </li><li><a href="/search/?q=author%3AFoo%2C%20Jerome%20C">Foo, Jerome C</a>; </li><li><a href="/search/?q=author%3AForstner%2C%20Andreas%20J">Forstner, Andreas J</a>; </li><li><a href="/search/?q=author%3AFrye%2C%20Mark">Frye, Mark</a>; </li><li><a href="/search/?q=author%3AFullerton%2C%20Janice%20M">Fullerton, Janice M</a>; </li><li><a href="/search/?q=author%3AGatt%2C%20Justine%20M">Gatt, Justine M</a>; </li><li><a href="/search/?q=author%3AGejman%2C%20Pablo%20V">Gejman, Pablo V</a>; </li><li><a href="/search/?q=author%3AGiegling%2C%20Ina">Giegling, Ina</a>; </li><li><a href="/search/?q=author%3AGrabe%2C%20Hans%20J">Grabe, Hans J</a>; </li><li><a href="/search/?q=author%3AGreen%2C%20Melissa%20J">Green, Melissa J</a>; </li><li><a href="/search/?q=author%3AGrevet%2C%20Eugenio%20H">Grevet, Eugenio H</a>; </li><li><a href="/search/?q=author%3AGrigoroiu-Serbanescu%2C%20Maria">Grigoroiu-Serbanescu, Maria</a>; </li><li><a href="/search/?q=author%3AGutierrez%2C%20Blanca">Gutierrez, Blanca</a>; </li><li><a href="/search/?q=author%3AGuzman-Parra%2C%20Jose">Guzman-Parra, Jose</a>; </li><li><a href="/search/?q=author%3AHamilton%2C%20Steven%20P">Hamilton, Steven P</a>; </li><li><a href="/search/?q=author%3AHamshere%2C%20Marian%20L">Hamshere, Marian L</a>; </li><li><a href="/search/?q=author%3AHartmann%2C%20Annette">Hartmann, Annette</a>; </li><li><a href="/search/?q=author%3AHauser%2C%20Joanna">Hauser, Joanna</a>; </li><li><a href="/search/?q=author%3AHeilmann-Heimbach%2C%20Stefanie">Heilmann-Heimbach, Stefanie</a>; </li><li><a href="/search/?q=author%3AHoffmann%2C%20Per">Hoffmann, Per</a>; </li><li><a href="/search/?q=author%3AIsing%2C%20Marcus">Ising, Marcus</a>; </li><li><a href="/search/?q=author%3AJones%2C%20Ian">Jones, Ian</a>; </li><li><a href="/search/?q=author%3AJones%2C%20Lisa%20A">Jones, Lisa A</a>; </li><li><a href="/search/?q=author%3AJonsson%2C%20Lina">Jonsson, Lina</a>; </li><li><a href="/search/?q=author%3AKahn%2C%20Ren%C3%A9%20S">Kahn, René S</a>; </li><li><a href="/search/?q=author%3AKelsoe%2C%20John%20R">Kelsoe, John R</a>; </li><li><a href="/search/?q=author%3AKendler%2C%20Kenneth%20S">Kendler, Kenneth S</a>; </li><li><a href="/search/?q=author%3AKloiber%2C%20Stefan">Kloiber, Stefan</a>; </li><li><a href="/search/?q=author%3AKoenen%2C%20Karestan%20C">Koenen, Karestan C</a>; </li><li><a href="/search/?q=author%3AKogevinas%2C%20Manolis">Kogevinas, Manolis</a>; </li><li><a href="/search/?q=author%3AKonte%2C%20Bettina">Konte, Bettina</a>; </li><li><a href="/search/?q=author%3AKrebs%2C%20Marie-Odile">Krebs, Marie-Odile</a>; </li><li><a href="/search/?q=author%3ALand%C3%A9n%2C%20Mikael">Landén, Mikael</a>; </li><li><a href="/search/?q=author%3ALawrence%2C%20Jacob">Lawrence, Jacob</a>; </li><li><a href="/search/?q=author%3ALeboyer%2C%20Marion">Leboyer, Marion</a>; </li><li><a href="/search/?q=author%3ALee%2C%20Phil%20H">Lee, Phil H</a>; </li><li><a href="/search/?q=author%3ALevinson%2C%20Douglas%20F">Levinson, Douglas F</a>; </li><li><a href="/search/?q=author%3ALiao%2C%20Calwing">Liao, Calwing</a>; </li><li><a href="/search/?q=author%3ALissowska%2C%20Jolanta">Lissowska, Jolanta</a>; </li><li><a href="/search/?q=author%3ALucae%2C%20Susanne">Lucae, Susanne</a>; </li><li><a href="/search/?q=author%3AMayoral%2C%20Fermin">Mayoral, Fermin</a>; </li><li><a href="/search/?q=author%3AMcElroy%2C%20Susan%20L">McElroy, Susan L</a>; </li><li><a href="/search/?q=author%3AMcGrath%2C%20Patrick">McGrath, Patrick</a>; </li><li><a href="/search/?q=author%3AMcGuffin%2C%20Peter">McGuffin, Peter</a>; </li><li><a href="/search/?q=author%3AMcQuillin%2C%20Andrew">McQuillin, Andrew</a>; </li><li><a href="/search/?q=author%3AMedland%2C%20Sarah%20E">Medland, Sarah E</a>; </li><li><a href="/search/?q=author%3AMehta%2C%20Divya">Mehta, Divya</a>; </li><li><a href="/search/?q=author%3AMelle%2C%20Ingrid">Melle, Ingrid</a>; </li><li><a href="/search/?q=author%3AMilaneschi%2C%20Yuri">Milaneschi, Yuri</a>; </li><li><a href="/search/?q=author%3AMitchell%2C%20Philip%20B">Mitchell, Philip B</a>; </li><li><a href="/search/?q=author%3AMolina%2C%20Esther">Molina, Esther</a>; </li><li><a href="/search/?q=author%3AMorken%2C%20Gunnar">Morken, Gunnar</a>; </li><li><a href="/search/?q=author%3AMortensen%2C%20Preben%20Bo">Mortensen, Preben Bo</a>; </li><li><a href="/search/?q=author%3AM%C3%BCller-Myhsok%2C%20Bertram">Müller-Myhsok, Bertram</a>; </li><li><a href="/search/?q=author%3ANievergelt%2C%20Caroline">Nievergelt, Caroline</a>; </li><li><a href="/search/?q=author%3ANimgaonkar%2C%20Vishwajit">Nimgaonkar, Vishwajit</a>; </li><li><a href="/search/?q=author%3AN%C3%B6then%2C%20Markus%20M">Nöthen, Markus M</a>; </li><li><a href="/search/?q=author%3AO'Donovan%2C%20Michael%20C">O'Donovan, Michael C</a>; </li><li><a href="/search/?q=author%3AOphoff%2C%20Roel%20A">Ophoff, Roel A</a>; </li><li><a href="/search/?q=author%3AOwen%2C%20Michael%20J">Owen, Michael J</a>; </li><li><a href="/search/?q=author%3APato%2C%20Carlos">Pato, Carlos</a>; </li><li><a href="/search/?q=author%3APato%2C%20Michele%20T">Pato, Michele T</a>; </li><li><a href="/search/?q=author%3APenninx%2C%20Brenda%20WJH">Penninx, Brenda WJH</a>; </li><li><a href="/search/?q=author%3APimm%2C%20Jonathan">Pimm, Jonathan</a>; </li><li><a href="/search/?q=author%3APistis%2C%20Giorgio">Pistis, Giorgio</a>; </li><li><a href="/search/?q=author%3APotash%2C%20James%20B">Potash, James B</a>; </li><li><a href="/search/?q=author%3APower%2C%20Robert%20A">Power, Robert A</a>; </li><li><a href="/search/?q=author%3APreisig%2C%20Martin">Preisig, Martin</a>; </li><li><a href="/search/?q=author%3AQuested%2C%20Digby">Quested, Digby</a>; </li><li><a href="/search/?q=author%3ARamos-Quiroga%2C%20Josep%20Antoni">Ramos-Quiroga, Josep Antoni</a>; </li><li><a href="/search/?q=author%3AReif%2C%20Andreas">Reif, Andreas</a>; </li><li><a href="/search/?q=author%3ARibas%C3%A9s%2C%20Marta">Ribasés, Marta</a>; </li><li><a href="/search/?q=author%3ARicharte%2C%20Vanesa">Richarte, Vanesa</a>; </li><li><a href="/search/?q=author%3ARietschel%2C%20Marcella">Rietschel, Marcella</a>; </li><li><a href="/search/?q=author%3ARivera%2C%20Margarita">Rivera, Margarita</a>; </li><li><a href="/search/?q=author%3ARoberts%2C%20Andrea">Roberts, Andrea</a>; </li><li><a href="/search/?q=author%3ARoberts%2C%20Gloria">Roberts, Gloria</a>; </li><li><a href="/search/?q=author%3ARouleau%2C%20Guy%20A">Rouleau, Guy A</a>; </li><li><a href="/search/?q=author%3ARovaris%2C%20Diego%20L">Rovaris, Diego L</a>; </li><li><a href="/search/?q=author%3ARujescu%2C%20Dan">Rujescu, Dan</a>; </li><li><a href="/search/?q=author%3AS%C3%A1nchez-Mora%2C%20Cristina">Sánchez-Mora, Cristina</a>; </li><li><a href="/search/?q=author%3ASanders%2C%20Alan%20R">Sanders, Alan R</a>; </li><li><a href="/search/?q=author%3ASchofield%2C%20Peter%20R">Schofield, Peter R</a>; </li><li><a href="/search/?q=author%3ASchulze%2C%20Thomas%20G">Schulze, Thomas G</a>; </li><li><a href="/search/?q=author%3AScott%2C%20Laura%20J">Scott, Laura J</a>; </li><li><a href="/search/?q=author%3ASerretti%2C%20Alessandro">Serretti, Alessandro</a>; </li><li><a href="/search/?q=author%3AShi%2C%20Jianxin">Shi, Jianxin</a>; </li><li><a href="/search/?q=author%3AShyn%2C%20Stanley%20I">Shyn, Stanley I</a>; </li><li><a href="/search/?q=author%3ASirignano%2C%20Lea">Sirignano, Lea</a>; </li><li><a href="/search/?q=author%3ASklar%2C%20Pamela">Sklar, Pamela</a>; </li><li><a href="/search/?q=author%3ASmeland%2C%20Olav%20B">Smeland, Olav B</a>; </li><li><a href="/search/?q=author%3ASmoller%2C%20Jordan%20W">Smoller, Jordan W</a>; </li><li><a href="/search/?q=author%3ASonuga-Barke%2C%20Edmund%20JS">Sonuga-Barke, Edmund JS</a>; </li><li><a href="/search/?q=author%3ASpalletta%2C%20Gianfranco">Spalletta, Gianfranco</a>; </li><li><a href="/search/?q=author%3AStrauss%2C%20John%20S">Strauss, John S</a>; </li><li><a href="/search/?q=author%3A%C5%9Awi%C4%85tkowska%2C%20Beata">Świątkowska, Beata</a>; </li><li><a href="/search/?q=author%3ATrzaskowski%2C%20Maciej">Trzaskowski, Maciej</a>; </li><li><a href="/search/?q=author%3ATurecki%2C%20Gustavo">Turecki, Gustavo</a>; </li><li><a href="/search/?q=author%3AVilar-Rib%C3%B3%2C%20Laura">Vilar-Ribó, Laura</a>; </li><li><a href="/search/?q=author%3AVincent%2C%20John%20B">Vincent, John B</a>; </li><li><a href="/search/?q=author%3AV%C3%B6lzke%2C%20Henry">Völzke, Henry</a>; </li><li><a href="/search/?q=author%3AWalters%2C%20James%20TR">Walters, James TR</a>; </li><li><a href="/search/?q=author%3AShannon%20Weickert%2C%20Cynthia">Shannon Weickert, Cynthia</a>; </li><li><a href="/search/?q=author%3AWeickert%2C%20Thomas%20W">Weickert, Thomas W</a>; </li><li><a href="/search/?q=author%3AWeissman%2C%20Myrna%20M">Weissman, Myrna M</a>; </li><li><a href="/search/?q=author%3AWilliams%2C%20Leanne%20M">Williams, Leanne M</a>; </li><li><a href="/search/?q=author%3AWray%2C%20Naomi%20R">Wray, Naomi R</a>; </li><li><a href="/search/?q=author%3AZai%2C%20Clement%20C">Zai, Clement C</a>; </li><li><a href="/search/?q=author%3AAshley-Koch%2C%20Allison%20E">Ashley-Koch, Allison E</a>; </li><li><a href="/search/?q=author%3ABeckham%2C%20Jean%20C">Beckham, Jean C</a>; </li><li><a href="/search/?q=author%3AHauser%2C%20Elizabeth%20R">Hauser, Elizabeth R</a>; </li><li><a href="/search/?q=author%3AHauser%2C%20Michael%20A">Hauser, Michael A</a>; </li><li><a href="/search/?q=author%3AKimbrel%2C%20Nathan%20A">Kimbrel, Nathan A</a>; </li><li><a href="/search/?q=author%3ALindquist%2C%20Jennifer%20H">Lindquist, Jennifer H</a>; </li><li><a href="/search/?q=author%3AMcMahon%2C%20Benjamin">McMahon, Benjamin</a>; </li><li><a href="/search/?q=author%3AOslin%2C%20David%20W">Oslin, David W</a>; </li><li><a href="/search/?q=author%3AQin%2C%20Xuejun">Qin, Xuejun</a>; </li><li><a href="/search/?q=author%3AMajor%20Depressive%20Disorder%20Working%20Group%20of%20the%20Psychiatric%20Genomics%20Consortium">Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium</a>; </li><li><a href="/search/?q=author%3ABipolar%20Disorder%20Working%20Group%20of%20the%20Psychiatric%20Genomics%20Consortium">Bipolar Disorder Working Group of the Psychiatric Genomics Consortium</a>; </li><li><a href="/search/?q=author%3AEating%20Disorders%20Working%20Group%20of%20the%20Psychiatric%20Genomics%20Consortium">Eating Disorders Working Group of the Psychiatric Genomics Consortium</a>; </li><li><a href="/search/?q=author%3AGerman%20Borderline%20Genomics%20Consortium">German Borderline Genomics Consortium</a>; </li><li><a href="/search/?q=author%3AMVP%20Suicide%20Exemplar%20Workgroup">MVP Suicide Exemplar Workgroup</a>; </li><li><a href="/search/?q=author%3AVA%20Million%20Veteran%20Program">VA Million Veteran Program</a>; </li><li><a href="/search/?q=author%3AAgerbo%2C%20Esben">Agerbo, Esben</a>; </li><li><a href="/search/?q=author%3AB%C3%B8rglum%2C%20Anders%20D">Børglum, Anders D</a>; </li><li><a href="/search/?q=author%3ABreen%2C%20Gerome">Breen, Gerome</a>; </li><li><a href="/search/?q=author%3AErlangsen%2C%20Annette">Erlangsen, Annette</a>; </li><li><a href="/search/?q=author%3AEsko%2C%20T%C3%B5nu">Esko, Tõnu</a>; </li><li><a href="/search/?q=author%3AGelernter%2C%20Joel">Gelernter, Joel</a>; </li><li><a href="/search/?q=author%3AHougaard%2C%20David%20M">Hougaard, David M</a>; </li><li><a href="/search/?q=author%3AKessler%2C%20Ronald%20C">Kessler, Ronald C</a>; </li><li><a href="/search/?q=author%3AKranzler%2C%20Henry%20R">Kranzler, Henry R</a>; </li><li><a href="/search/?q=author%3ALi%2C%20Qingqin%20S">Li, Qingqin S</a>; </li><li><a href="/search/?q=author%3AMartin%2C%20Nicholas%20G">Martin, Nicholas G</a>; </li><li><a href="/search/?q=author%3AMcIntosh%2C%20Andrew%20M">McIntosh, Andrew M</a>; </li><li><a href="/search/?q=author%3AMors%2C%20Ole">Mors, Ole</a>; </li><li><a href="/search/?q=author%3ANordentoft%2C%20Merete">Nordentoft, Merete</a>; </li><li><a href="/search/?q=author%3AOlsen%2C%20Catherine%20M">Olsen, Catherine M</a>; </li><li><a href="/search/?q=author%3APorteous%2C%20David">Porteous, David</a>; </li><li><a href="/search/?q=author%3AUrsano%2C%20Robert%20J">Ursano, Robert J</a>; </li><li><a href="/search/?q=author%3AWasserman%2C%20Danuta">Wasserman, Danuta</a>; </li><li><a href="/search/?q=author%3AWerge%2C%20Thomas">Werge, Thomas</a>; </li><li><a href="/search/?q=author%3AWhiteman%2C%20David%20C">Whiteman, David C</a>; </li><li><a href="/search/?q=author%3ABulik%2C%20Cynthia%20M">Bulik, Cynthia M</a>; </li><li><a href="/search/?q=author%3ACoon%2C%20Hilary">Coon, Hilary</a>; </li><li><a href="/search/?q=author%3ADemontis%2C%20Ditte">Demontis, Ditte</a>; </li><li><a href="/search/?q=author%3ADocherty%2C%20Anna%20R">Docherty, Anna R</a>; </li><li><a href="/search/?q=author%3AKuo%2C%20Po-Hsiu">Kuo, Po-Hsiu</a>; </li><li><a href="/search/?q=author%3ALewis%2C%20Cathryn%20M">Lewis, Cathryn M</a>; </li><li><a href="/search/?q=author%3AMann%2C%20J%20John">Mann, J John</a>; </li><li><a href="/search/?q=author%3ARenter%C3%ADa%2C%20Miguel%20E">Rentería, Miguel E</a>; </li><li><a href="/search/?q=author%3ASmith%2C%20Daniel%20J">Smith, Daniel J</a>; </li><li><a href="/search/?q=author%3AStahl%2C%20Eli%20A">Stahl, Eli A</a>; </li><li><a href="/search/?q=author%3AStein%2C%20Murray%20B">Stein, Murray B</a>; </li><li><a href="/search/?q=author%3AStreit%2C%20Fabian">Streit, Fabian</a>; </li><li><a href="/search/?q=author%3AWillour%2C%20Virginia">Willour, Virginia</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3ARuderfer%2C%20Douglas%20M">Ruderfer, Douglas M</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucsd_postprints">UC San Diego Previously Published Works</a> (2022)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup"><h3>Background</h3>Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders.<h3>Methods</h3>We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors.<h3>Results</h3>Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged.<h3>Conclusions</h3>Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/8jn2p3sp"><img src="/cms-assets/bc5d72f5f7034394ff0bc5bbecdf3cabad796fffef9f3845cd94fc3545635219" alt="Cover page: Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors."/></a><a href="https://creativecommons.org/licenses/by-nc-nd/4.0/" class="c-scholworks__license"><img class="c-lazyimage" data-src="/images/cc-by-nc-nd-small.svg" alt="Creative Commons 'BY-NC-ND' version 4.0 license"/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/7m0047ch"><div class="c-clientmarkup">Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3AConsortium%2C%20Bipolar%20Disorder%20and%20Schizophrenia%20Working%20Group%20of%20the%20Psychiatric%20Genomics">Consortium, Bipolar Disorder and Schizophrenia Working Group of the Psychiatric Genomics</a>; </li><li><a href="/search/?q=author%3ARuderfer%2C%20Douglas%20M">Ruderfer, Douglas M</a>; </li><li><a href="/search/?q=author%3ARipke%2C%20Stephan">Ripke, Stephan</a>; </li><li><a href="/search/?q=author%3AMcQuillin%2C%20Andrew">McQuillin, Andrew</a>; </li><li><a href="/search/?q=author%3ABoocock%2C%20James">Boocock, James</a>; </li><li><a href="/search/?q=author%3AStahl%2C%20Eli%20A">Stahl, Eli A</a>; </li><li><a href="/search/?q=author%3APavlides%2C%20Jennifer%20M%20Whitehead">Pavlides, Jennifer M Whitehead</a>; </li><li><a href="/search/?q=author%3AMullins%2C%20Niamh">Mullins, Niamh</a>; </li><li><a href="/search/?q=author%3ACharney%2C%20Alexander%20W">Charney, Alexander W</a>; </li><li><a href="/search/?q=author%3AOri%2C%20Anil%20PS">Ori, Anil PS</a>; </li><li><a href="/search/?q=author%3ALoohuis%2C%20Loes%20M%20Olde">Loohuis, Loes M Olde</a>; </li><li><a href="/search/?q=author%3ADomenici%2C%20Enrico">Domenici, Enrico</a>; </li><li><a href="/search/?q=author%3ADi%20Florio%2C%20Arianna">Di Florio, Arianna</a>; </li><li><a href="/search/?q=author%3APapiol%2C%20Sergi">Papiol, Sergi</a>; </li><li><a href="/search/?q=author%3AKalman%2C%20Janos%20L">Kalman, Janos L</a>; </li><li><a href="/search/?q=author%3ATrubetskoy%2C%20Vassily">Trubetskoy, Vassily</a>; </li><li><a href="/search/?q=author%3AAdolfsson%2C%20Rolf">Adolfsson, Rolf</a>; </li><li><a href="/search/?q=author%3AAgartz%2C%20Ingrid">Agartz, Ingrid</a>; </li><li><a href="/search/?q=author%3AAgerbo%2C%20Esben">Agerbo, Esben</a>; </li><li><a href="/search/?q=author%3AAkil%2C%20Huda">Akil, Huda</a>; </li><li><a href="/search/?q=author%3AAlbani%2C%20Diego">Albani, Diego</a>; </li><li><a href="/search/?q=author%3AAlbus%2C%20Margot">Albus, Margot</a>; </li><li><a href="/search/?q=author%3AAlda%2C%20Martin">Alda, Martin</a>; </li><li><a href="/search/?q=author%3AAlexander%2C%20Madeline">Alexander, Madeline</a>; </li><li><a href="/search/?q=author%3AAlliey-Rodriguez%2C%20Ney">Alliey-Rodriguez, Ney</a>; </li><li><a href="/search/?q=author%3AAls%2C%20Thomas%20D">Als, Thomas D</a>; </li><li><a href="/search/?q=author%3AAmin%2C%20Farooq">Amin, Farooq</a>; </li><li><a href="/search/?q=author%3AAnjorin%2C%20Adebayo">Anjorin, Adebayo</a>; </li><li><a href="/search/?q=author%3AArranz%2C%20Maria%20J">Arranz, Maria J</a>; </li><li><a href="/search/?q=author%3AAwasthi%2C%20Swapnil">Awasthi, Swapnil</a>; </li><li><a href="/search/?q=author%3ABacanu%2C%20Silviu%20A">Bacanu, Silviu A</a>; </li><li><a href="/search/?q=author%3ABadner%2C%20Judith%20A">Badner, Judith A</a>; </li><li><a href="/search/?q=author%3ABaekvad-Hansen%2C%20Marie">Baekvad-Hansen, Marie</a>; </li><li><a href="/search/?q=author%3ABakker%2C%20Steven">Bakker, Steven</a>; </li><li><a href="/search/?q=author%3ABand%2C%20Gavin">Band, Gavin</a>; </li><li><a href="/search/?q=author%3ABarchas%2C%20Jack%20D">Barchas, Jack D</a>; </li><li><a href="/search/?q=author%3ABarroso%2C%20Ines">Barroso, Ines</a>; </li><li><a href="/search/?q=author%3ABass%2C%20Nicholas">Bass, Nicholas</a>; </li><li><a href="/search/?q=author%3ABauer%2C%20Michael">Bauer, Michael</a>; </li><li><a href="/search/?q=author%3ABaune%2C%20Bernhard%20T">Baune, Bernhard T</a>; </li><li><a href="/search/?q=author%3ABegemann%2C%20Martin">Begemann, Martin</a>; </li><li><a href="/search/?q=author%3ABellenguez%2C%20Celine">Bellenguez, Celine</a>; </li><li><a href="/search/?q=author%3ABelliveau%2C%20Richard%20A">Belliveau, Richard A</a>; </li><li><a href="/search/?q=author%3ABellivier%2C%20Frank">Bellivier, Frank</a>; </li><li><a href="/search/?q=author%3ABender%2C%20Stephan">Bender, Stephan</a>; </li><li><a href="/search/?q=author%3ABene%2C%20Judit">Bene, Judit</a>; </li><li><a href="/search/?q=author%3ABergen%2C%20Sarah%20E">Bergen, Sarah E</a>; </li><li><a href="/search/?q=author%3ABerrettini%2C%20Wade%20H">Berrettini, Wade H</a>; </li><li><a href="/search/?q=author%3ABevilacqua%2C%20Elizabeth">Bevilacqua, Elizabeth</a>; </li><li><a href="/search/?q=author%3ABiernacka%2C%20Joanna%20M">Biernacka, Joanna M</a>; </li><li><a href="/search/?q=author%3ABigdeli%2C%20Tim%20B">Bigdeli, Tim B</a>; </li><li><a href="/search/?q=author%3ABlack%2C%20Donald%20W">Black, Donald W</a>; </li><li><a href="/search/?q=author%3ABlackburn%2C%20Hannah">Blackburn, Hannah</a>; </li><li><a href="/search/?q=author%3ABlackwell%2C%20Jenefer%20M">Blackwell, Jenefer M</a>; </li><li><a href="/search/?q=author%3ABlackwood%2C%20Douglas%20HR">Blackwood, Douglas HR</a>; </li><li><a href="/search/?q=author%3APedersen%2C%20Carsten%20Bocker">Pedersen, Carsten Bocker</a>; </li><li><a href="/search/?q=author%3ABoehnke%2C%20Michael">Boehnke, Michael</a>; </li><li><a href="/search/?q=author%3ABoks%2C%20Marco">Boks, Marco</a>; </li><li><a href="/search/?q=author%3ABorglum%2C%20Anders%20D">Borglum, Anders D</a>; </li><li><a href="/search/?q=author%3ABramon%2C%20Elvira">Bramon, Elvira</a>; </li><li><a href="/search/?q=author%3ABreen%2C%20Gerome">Breen, Gerome</a>; </li><li><a href="/search/?q=author%3ABrown%2C%20Matthew%20A">Brown, Matthew A</a>; </li><li><a href="/search/?q=author%3ABruggeman%2C%20Richard">Bruggeman, Richard</a>; </li><li><a href="/search/?q=author%3ABuccola%2C%20Nancy%20G">Buccola, Nancy G</a>; </li><li><a href="/search/?q=author%3ABuckner%2C%20Randy%20L">Buckner, Randy L</a>; </li><li><a href="/search/?q=author%3ABudde%2C%20Monika">Budde, Monika</a>; </li><li><a href="/search/?q=author%3ABulik-Sullivan%2C%20Brendan">Bulik-Sullivan, Brendan</a>; </li><li><a href="/search/?q=author%3ABumpstead%2C%20Suzannah%20J">Bumpstead, Suzannah J</a>; </li><li><a href="/search/?q=author%3ABunney%2C%20William">Bunney, William</a>; </li><li><a href="/search/?q=author%3ABurmeister%2C%20Margit">Burmeister, Margit</a>; </li><li><a href="/search/?q=author%3ABuxbaum%2C%20Joseph%20D">Buxbaum, Joseph D</a>; </li><li><a href="/search/?q=author%3ABybjerg-Grauholm%2C%20Jonas">Bybjerg-Grauholm, Jonas</a>; </li><li><a href="/search/?q=author%3AByerley%2C%20William">Byerley, William</a>; </li><li><a href="/search/?q=author%3ACahn%2C%20Wiepke">Cahn, Wiepke</a>; </li><li><a href="/search/?q=author%3ACai%2C%20Guiqing">Cai, Guiqing</a>; </li><li><a href="/search/?q=author%3ACairns%2C%20Murray%20J">Cairns, Murray J</a>; </li><li><a href="/search/?q=author%3ACampion%2C%20Dominique">Campion, Dominique</a>; </li><li><a href="/search/?q=author%3ACantor%2C%20Rita%20M">Cantor, Rita M</a>; </li><li><a href="/search/?q=author%3ACarr%2C%20Vaughan%20J">Carr, Vaughan J</a>; </li><li><a href="/search/?q=author%3ACarrera%2C%20Noa">Carrera, Noa</a>; </li><li><a href="/search/?q=author%3ACasas%2C%20Juan%20P">Casas, Juan P</a>; </li><li><a href="/search/?q=author%3ACasas%2C%20Miquel">Casas, Miquel</a>; </li><li><a href="/search/?q=author%3ACatts%2C%20Stanley%20V">Catts, Stanley V</a>; </li><li><a href="/search/?q=author%3ACervantes%2C%20Pablo">Cervantes, Pablo</a>; </li><li><a href="/search/?q=author%3AChambert%2C%20Kimberley%20D">Chambert, Kimberley D</a>; </li><li><a href="/search/?q=author%3AChan%2C%20Raymond%20CK">Chan, Raymond CK</a>; </li><li><a href="/search/?q=author%3AChen%2C%20Eric%20YH">Chen, Eric YH</a>; </li><li><a href="/search/?q=author%3AChen%2C%20Ronald%20YL">Chen, Ronald YL</a>; </li><li><a href="/search/?q=author%3ACheng%2C%20Wei">Cheng, Wei</a>; </li><li><a href="/search/?q=author%3ACheung%2C%20Eric%20FC">Cheung, Eric FC</a>; </li><li><a href="/search/?q=author%3AChong%2C%20Siow%20Ann">Chong, Siow Ann</a>; </li><li><a href="/search/?q=author%3AClarke%2C%20Toni-Kim">Clarke, Toni-Kim</a>; </li><li><a href="/search/?q=author%3ACloninger%2C%20C%20Robert">Cloninger, C Robert</a>; </li><li><a href="/search/?q=author%3ACohen%2C%20David">Cohen, David</a>; </li><li><a href="/search/?q=author%3ACohen%2C%20Nadine">Cohen, Nadine</a>; </li><li><a href="/search/?q=author%3AColeman%2C%20Jonathan%20RI">Coleman, Jonathan RI</a>; </li><li><a href="/search/?q=author%3ACollier%2C%20David%20A">Collier, David A</a>; </li><li><a href="/search/?q=author%3ACormican%2C%20Paul">Cormican, Paul</a>; </li><li><a href="/search/?q=author%3ACoryell%2C%20William">Coryell, William</a>; </li><li><a href="/search/?q=author%3ACraddock%2C%20Nicholas">Craddock, Nicholas</a>; </li><li><a href="/search/?q=author%3ACraig%2C%20David%20W">Craig, David W</a>; </li><li><a href="/search/?q=author%3ACrespo-Facorro%2C%20Benedicto">Crespo-Facorro, Benedicto</a>; </li><li><a href="/search/?q=author%3ACrowley%2C%20James%20J">Crowley, James J</a>; </li><li><a href="/search/?q=author%3ACruceanu%2C%20Cristiana">Cruceanu, Cristiana</a>; </li><li><a href="/search/?q=author%3ACurtis%2C%20David">Curtis, David</a>; </li><li><a href="/search/?q=author%3ACzerski%2C%20Piotr%20M">Czerski, Piotr M</a>; </li><li><a href="/search/?q=author%3ADale%2C%20Anders%20M">Dale, Anders M</a>; </li><li><a href="/search/?q=author%3ADaly%2C%20Mark%20J">Daly, Mark J</a>; </li><li><a href="/search/?q=author%3ADannlowski%2C%20Udo">Dannlowski, Udo</a>; </li><li><a href="/search/?q=author%3ADarvasi%2C%20Ariel">Darvasi, Ariel</a>; </li><li><a href="/search/?q=author%3ADavidson%2C%20Michael">Davidson, Michael</a>; </li><li><a href="/search/?q=author%3ADavis%2C%20Kenneth%20L">Davis, Kenneth L</a>; </li><li><a href="/search/?q=author%3Ade%20Leeuw%2C%20Christiaan%20A">de Leeuw, Christiaan A</a>; </li><li><a href="/search/?q=author%3ADegenhardt%2C%20Franziska">Degenhardt, Franziska</a>; </li><li><a href="/search/?q=author%3ADel%20Favero%2C%20Jurgen">Del Favero, Jurgen</a>; </li><li><a href="/search/?q=author%3ADeLisi%2C%20Lynn%20E">DeLisi, Lynn E</a>; </li><li><a href="/search/?q=author%3ADeloukas%2C%20Panos">Deloukas, Panos</a>; </li><li><a href="/search/?q=author%3ADemontis%2C%20Ditte">Demontis, Ditte</a>; </li><li><a href="/search/?q=author%3ADePaulo%2C%20J%20Raymond">DePaulo, J Raymond</a>; </li><li><a href="/search/?q=author%3Adi%20Forti%2C%20Marta">di Forti, Marta</a>; </li><li><a href="/search/?q=author%3ADikeos%2C%20Dimitris">Dikeos, Dimitris</a>; </li><li><a href="/search/?q=author%3ADinan%2C%20Timothy">Dinan, Timothy</a>; </li><li><a href="/search/?q=author%3ADjurovic%2C%20Srdjan">Djurovic, Srdjan</a>; </li><li><a href="/search/?q=author%3ADobbyn%2C%20Amanda%20L">Dobbyn, Amanda L</a>; </li><li><a href="/search/?q=author%3ADonnelly%2C%20Peter">Donnelly, Peter</a>; </li><li><a href="/search/?q=author%3ADonohoe%2C%20Gary">Donohoe, Gary</a>; </li><li><a href="/search/?q=author%3ADrapeau%2C%20Elodie">Drapeau, Elodie</a>; </li><li><a href="/search/?q=author%3ADronov%2C%20Serge">Dronov, Serge</a>; </li><li><a href="/search/?q=author%3ADuan%2C%20Jubao">Duan, Jubao</a>; </li><li><a href="/search/?q=author%3ADudbridge%2C%20Frank">Dudbridge, Frank</a>; </li><li><a href="/search/?q=author%3ADuncanson%2C%20Audrey">Duncanson, Audrey</a>; </li><li><a href="/search/?q=author%3AEdenberg%2C%20Howard">Edenberg, Howard</a>; </li><li><a href="/search/?q=author%3AEdkins%2C%20Sarah">Edkins, Sarah</a>; </li><li><a href="/search/?q=author%3AEhrenreich%2C%20Hannelore">Ehrenreich, Hannelore</a>; </li><li><a href="/search/?q=author%3AEichhammer%2C%20Peter">Eichhammer, Peter</a>; </li><li><a href="/search/?q=author%3AElvsashagen%2C%20Torbjorn">Elvsashagen, Torbjorn</a>; </li><li><a href="/search/?q=author%3AEriksson%2C%20Johan">Eriksson, Johan</a>; </li><li><a href="/search/?q=author%3AEscott-Price%2C%20Valentina">Escott-Price, Valentina</a>; </li><li><a href="/search/?q=author%3AEsko%2C%20Tonu">Esko, Tonu</a>; </li><li><a href="/search/?q=author%3AEssioux%2C%20Laurent">Essioux, Laurent</a>; </li><li><a href="/search/?q=author%3AEtain%2C%20Bruno">Etain, Bruno</a>; </li><li><a href="/search/?q=author%3AFan%2C%20Chun%20Chieh">Fan, Chun Chieh</a>; </li><li><a href="/search/?q=author%3AFarh%2C%20Kai-How">Farh, Kai-How</a>; </li><li><a href="/search/?q=author%3AFarrell%2C%20Martilias%20S">Farrell, Martilias S</a>; </li><li><a href="/search/?q=author%3AFlickinger%2C%20Matthew">Flickinger, Matthew</a>; </li><li><a href="/search/?q=author%3AForoud%2C%20Tatiana%20M">Foroud, Tatiana M</a>; </li><li><a href="/search/?q=author%3AForty%2C%20Liz">Forty, Liz</a>; </li><li><a href="/search/?q=author%3AFrank%2C%20Josef">Frank, Josef</a>; </li><li><a href="/search/?q=author%3AFranke%2C%20Lude">Franke, Lude</a>; </li><li><a href="/search/?q=author%3AFraser%2C%20Christine">Fraser, Christine</a>; </li><li><a href="/search/?q=author%3AFreedman%2C%20Robert">Freedman, Robert</a>; </li><li><a href="/search/?q=author%3AFreeman%2C%20Colin">Freeman, Colin</a>; </li><li><a href="/search/?q=author%3AFreimer%2C%20Nelson%20B">Freimer, Nelson B</a>; </li><li><a href="/search/?q=author%3AFriedman%2C%20Joseph%20I">Friedman, Joseph I</a>; </li><li><a href="/search/?q=author%3AFromer%2C%20Menachem">Fromer, Menachem</a>; </li><li><a href="/search/?q=author%3AFrye%2C%20Mark%20A">Frye, Mark A</a>; </li><li><a href="/search/?q=author%3AFullerton%2C%20Janice%20M">Fullerton, Janice M</a>; </li><li><a href="/search/?q=author%3AGade%2C%20Katrin">Gade, Katrin</a>; </li><li><a href="/search/?q=author%3AGarnham%2C%20Julie">Garnham, Julie</a>; </li><li><a href="/search/?q=author%3AGaspar%2C%20Helena%20A">Gaspar, Helena A</a>; </li><li><a href="/search/?q=author%3AGejman%2C%20Pablo%20V">Gejman, Pablo V</a>; </li><li><a href="/search/?q=author%3AGenovese%2C%20Giulio">Genovese, Giulio</a>; </li><li><a href="/search/?q=author%3AGeorgieva%2C%20Lyudmila">Georgieva, Lyudmila</a>; </li><li><a href="/search/?q=author%3AGiambartolomei%2C%20Claudia">Giambartolomei, Claudia</a>; </li><li><a href="/search/?q=author%3AGiannoulatou%2C%20Eleni">Giannoulatou, Eleni</a>; </li><li><a href="/search/?q=author%3AGiegling%2C%20Ina">Giegling, Ina</a>; </li><li><a href="/search/?q=author%3AGill%2C%20Michael">Gill, Michael</a>; </li><li><a href="/search/?q=author%3AGillman%2C%20Matthew">Gillman, Matthew</a>; </li><li><a href="/search/?q=author%3APedersen%2C%20Marianne%20Giortz">Pedersen, Marianne Giortz</a>; </li><li><a href="/search/?q=author%3AGiusti-Rodriguez%2C%20Paola">Giusti-Rodriguez, Paola</a>; </li><li><a href="/search/?q=author%3AGodard%2C%20Stephanie">Godard, Stephanie</a>; </li><li><a href="/search/?q=author%3AGoes%2C%20Fernando">Goes, Fernando</a>; </li><li><a href="/search/?q=author%3AGoldstein%2C%20Jacqueline%20I">Goldstein, Jacqueline I</a>; </li><li><a href="/search/?q=author%3AGopal%2C%20Srihari">Gopal, Srihari</a>; </li><li><a href="/search/?q=author%3AGordon%2C%20Scott%20D">Gordon, Scott D</a>; </li><li><a href="/search/?q=author%3AGordon-Smith%2C%20Katherine">Gordon-Smith, Katherine</a>; </li><li><a href="/search/?q=author%3AGratten%2C%20Jacob">Gratten, Jacob</a>; </li><li><a href="/search/?q=author%3AGray%2C%20Emma">Gray, Emma</a>; </li><li><a href="/search/?q=author%3AGreen%2C%20Elaine%20K">Green, Elaine K</a>; </li><li><a href="/search/?q=author%3AGreen%2C%20Melissa%20J">Green, Melissa J</a>; </li><li><a href="/search/?q=author%3AGreenwood%2C%20Tiffany%20A">Greenwood, Tiffany A</a>; </li><li><a href="/search/?q=author%3AGrigoroiu-Serbanescu%2C%20Maria">Grigoroiu-Serbanescu, Maria</a>; </li><li><a href="/search/?q=author%3AGrove%2C%20Jakob">Grove, Jakob</a>; </li><li><a href="/search/?q=author%3AGuan%2C%20Weihua">Guan, Weihua</a>; </li><li><a href="/search/?q=author%3AGurling%2C%20Hugh">Gurling, Hugh</a>; </li><li><a href="/search/?q=author%3AParra%2C%20Jose%20Guzman">Parra, Jose Guzman</a>; </li><li><a href="/search/?q=author%3AGwilliam%2C%20Rhian">Gwilliam, Rhian</a>; </li><li><a href="/search/?q=author%3Ade%20Haan%2C%20Lieuwe">de Haan, Lieuwe</a>; </li><li><a href="/search/?q=author%3AHall%2C%20Jeremy">Hall, Jeremy</a>; </li><li><a href="/search/?q=author%3AHall%2C%20Mei-Hua">Hall, Mei-Hua</a>; </li><li><a href="/search/?q=author%3AHammer%2C%20Christian">Hammer, Christian</a>; </li><li><a href="/search/?q=author%3AHammond%2C%20Naomi">Hammond, Naomi</a>; </li><li><a href="/search/?q=author%3AHamshere%2C%20Marian%20L">Hamshere, Marian L</a>; </li><li><a href="/search/?q=author%3AHansen%2C%20Mark">Hansen, Mark</a>; </li><li><a href="/search/?q=author%3AHansen%2C%20Thomas">Hansen, Thomas</a>; </li><li><a href="/search/?q=author%3AHaroutunian%2C%20Vahram">Haroutunian, Vahram</a>; </li><li><a href="/search/?q=author%3AHartmann%2C%20Annette%20M">Hartmann, Annette M</a>; </li><li><a href="/search/?q=author%3AHauser%2C%20Joanna">Hauser, Joanna</a>; </li><li><a href="/search/?q=author%3AHautzinger%2C%20Martin">Hautzinger, Martin</a>; </li><li><a href="/search/?q=author%3AHeilbronner%2C%20Urs">Heilbronner, Urs</a>; </li><li><a href="/search/?q=author%3AHellenthal%2C%20Garrett">Hellenthal, Garrett</a>; </li><li><a href="/search/?q=author%3AHenskens%2C%20Frans%20A">Henskens, Frans A</a>; </li><li><a href="/search/?q=author%3AHerms%2C%20Stefan">Herms, Stefan</a>; </li><li><a href="/search/?q=author%3AHipolito%2C%20Maria">Hipolito, Maria</a>; </li><li><a href="/search/?q=author%3AHirschhorn%2C%20Joel%20N">Hirschhorn, Joel N</a>; </li><li><a href="/search/?q=author%3AHoffmann%2C%20Per">Hoffmann, Per</a>; </li><li><a href="/search/?q=author%3AHollegaard%2C%20Mads%20V">Hollegaard, Mads V</a>; </li><li><a href="/search/?q=author%3AHougaard%2C%20David%20M">Hougaard, David M</a>; </li><li><a href="/search/?q=author%3AHuang%2C%20Hailiang">Huang, Hailiang</a>; </li><li><a href="/search/?q=author%3AHuckins%2C%20Laura">Huckins, Laura</a>; </li><li><a href="/search/?q=author%3AHultman%2C%20Christina%20M">Hultman, Christina M</a>; </li><li><a href="/search/?q=author%3AHunt%2C%20Sarah%20E">Hunt, Sarah E</a>; </li><li><a href="/search/?q=author%3AIkeda%2C%20Masashi">Ikeda, Masashi</a>; </li><li><a href="/search/?q=author%3AIwata%2C%20Nakao">Iwata, Nakao</a>; </li><li><a href="/search/?q=author%3AIyegbe%2C%20Conrad">Iyegbe, Conrad</a>; </li><li><a href="/search/?q=author%3AJablensky%2C%20Assen%20V">Jablensky, Assen V</a>; </li><li><a href="/search/?q=author%3AJamain%2C%20Stephane">Jamain, Stephane</a>; </li><li><a href="/search/?q=author%3AJankowski%2C%20Janusz">Jankowski, Janusz</a>; </li><li><a href="/search/?q=author%3AJayakumar%2C%20Alagurevathi">Jayakumar, Alagurevathi</a>; </li><li><a href="/search/?q=author%3AJoa%2C%20Inge">Joa, Inge</a>; </li><li><a href="/search/?q=author%3AJones%2C%20Ian">Jones, Ian</a>; </li><li><a href="/search/?q=author%3AJones%2C%20Lisa%20A">Jones, Lisa A</a>; </li><li><a href="/search/?q=author%3AJonsson%2C%20Erik%20G">Jonsson, Erik G</a>; </li><li><a href="/search/?q=author%3AJulia%2C%20Antonio">Julia, Antonio</a>; </li><li><a href="/search/?q=author%3AJureus%2C%20Anders">Jureus, Anders</a>; </li><li><a href="/search/?q=author%3AKahler%2C%20Anna%20K">Kahler, Anna K</a>; </li><li><a href="/search/?q=author%3AKahn%2C%20Rene%20S">Kahn, Rene S</a>; </li><li><a href="/search/?q=author%3AKalaydjieva%2C%20Luba">Kalaydjieva, Luba</a>; </li><li><a href="/search/?q=author%3AKandaswamy%2C%20Radhika">Kandaswamy, Radhika</a>; </li><li><a href="/search/?q=author%3AKarachanak-Yankova%2C%20Sena">Karachanak-Yankova, Sena</a>; </li><li><a href="/search/?q=author%3AKarjalainen%2C%20Juha">Karjalainen, Juha</a>; </li><li><a href="/search/?q=author%3AKarlsson%2C%20Robert">Karlsson, Robert</a>; </li><li><a href="/search/?q=author%3AKavanagh%2C%20David">Kavanagh, David</a>; </li><li><a href="/search/?q=author%3AKeller%2C%20Matthew%20C">Keller, Matthew C</a>; </li><li><a href="/search/?q=author%3AKelly%2C%20Brian%20J">Kelly, Brian J</a>; </li><li><a href="/search/?q=author%3AKelsoe%2C%20John">Kelsoe, John</a>; </li><li><a href="/search/?q=author%3AKennedy%2C%20James%20L">Kennedy, James L</a>; </li><li><a href="/search/?q=author%3AKhrunin%2C%20Andrey">Khrunin, Andrey</a>; </li><li><a href="/search/?q=author%3AKim%2C%20Yunjung">Kim, Yunjung</a>; </li><li><a href="/search/?q=author%3AKirov%2C%20George">Kirov, George</a>; </li><li><a href="/search/?q=author%3AKittel-Schneider%2C%20Sarah">Kittel-Schneider, Sarah</a>; </li><li><a href="/search/?q=author%3AKlovins%2C%20Janis">Klovins, Janis</a>; </li><li><a href="/search/?q=author%3AKnight%2C%20Jo">Knight, Jo</a>; </li><li><a href="/search/?q=author%3AKnott%2C%20Sarah%20V">Knott, Sarah V</a>; </li><li><a href="/search/?q=author%3AKnowles%2C%20James%20A">Knowles, James A</a>; </li><li><a href="/search/?q=author%3AKogevinas%2C%20Manolis">Kogevinas, Manolis</a>; </li><li><a href="/search/?q=author%3AKonte%2C%20Bettina">Konte, Bettina</a>; </li><li><a href="/search/?q=author%3AKravariti%2C%20Eugenia">Kravariti, Eugenia</a>; </li><li><a href="/search/?q=author%3AKucinskas%2C%20Vaidutis">Kucinskas, Vaidutis</a>; </li><li><a href="/search/?q=author%3AKucinskiene%2C%20Zita%20Ausrele">Kucinskiene, Zita Ausrele</a>; </li><li><a href="/search/?q=author%3AKupka%2C%20Ralph">Kupka, Ralph</a>; </li><li><a href="/search/?q=author%3AKuzelova-Ptackova%2C%20Hana">Kuzelova-Ptackova, Hana</a>; </li><li><a href="/search/?q=author%3ALanden%2C%20Mikael">Landen, Mikael</a>; </li><li><a href="/search/?q=author%3ALangford%2C%20Cordelia">Langford, Cordelia</a>; </li><li><a href="/search/?q=author%3ALaurent%2C%20Claudine">Laurent, Claudine</a>; </li><li><a href="/search/?q=author%3ALawrence%2C%20Jacob">Lawrence, Jacob</a>; </li><li><a href="/search/?q=author%3ALawrie%2C%20Stephen">Lawrie, Stephen</a>; </li><li><a href="/search/?q=author%3ALawson%2C%20William%20B">Lawson, William B</a>; </li><li><a href="/search/?q=author%3ALeber%2C%20Markus">Leber, Markus</a>; </li><li><a href="/search/?q=author%3ALeboyer%2C%20Marion">Leboyer, Marion</a>; </li><li><a href="/search/?q=author%3ALee%2C%20Phil%20H">Lee, Phil H</a>; </li><li><a href="/search/?q=author%3AKeong%2C%20Jimmy%20Lee%20Chee">Keong, Jimmy Lee Chee</a>; </li><li><a href="/search/?q=author%3ALegge%2C%20Sophie%20E">Legge, Sophie E</a>; </li><li><a href="/search/?q=author%3ALencz%2C%20Todd">Lencz, Todd</a>; </li><li><a href="/search/?q=author%3ALerer%2C%20Bernard">Lerer, Bernard</a>; </li><li><a href="/search/?q=author%3ALevinson%2C%20Douglas%20F">Levinson, Douglas F</a>; </li><li><a href="/search/?q=author%3ALevy%2C%20Shawn%20E">Levy, Shawn E</a>; </li><li><a href="/search/?q=author%3ALewis%2C%20Cathryn%20M">Lewis, Cathryn M</a>; </li><li><a href="/search/?q=author%3ALi%2C%20Jun%20Z">Li, Jun Z</a>; </li><li><a href="/search/?q=author%3ALi%2C%20Miaoxin">Li, Miaoxin</a>; </li><li><a href="/search/?q=author%3ALi%2C%20Qingqin%20S">Li, Qingqin S</a>; </li><li><a href="/search/?q=author%3ALi%2C%20Tao">Li, Tao</a>; </li><li><a href="/search/?q=author%3ALiang%2C%20Kung-Yee">Liang, Kung-Yee</a>; </li><li><a href="/search/?q=author%3ALiddle%2C%20Jennifer">Liddle, Jennifer</a>; </li><li><a href="/search/?q=author%3ALieberman%2C%20Jeffrey">Lieberman, Jeffrey</a>; </li><li><a href="/search/?q=author%3ALimborska%2C%20Svetlana">Limborska, Svetlana</a>; </li><li><a href="/search/?q=author%3ALin%2C%20Kuang">Lin, Kuang</a>; </li><li><a href="/search/?q=author%3ALinszen%2C%20Don%20H">Linszen, Don H</a>; </li><li><a href="/search/?q=author%3ALissowska%2C%20Jolanta">Lissowska, Jolanta</a>; </li><li><a href="/search/?q=author%3ALiu%2C%20Chunyu">Liu, Chunyu</a>; </li><li><a href="/search/?q=author%3ALiu%2C%20Jianjun">Liu, Jianjun</a>; </li><li><a href="/search/?q=author%3ALonnqvist%2C%20Jouko">Lonnqvist, Jouko</a>; </li><li><a href="/search/?q=author%3ALoughland%2C%20Carmel%20M">Loughland, Carmel M</a>; </li><li><a href="/search/?q=author%3ALubinski%2C%20Jan">Lubinski, Jan</a>; </li><li><a href="/search/?q=author%3ALucae%2C%20Susanne">Lucae, Susanne</a>; </li><li><a href="/search/?q=author%3AMacek%2C%20Milan">Macek, Milan</a>; </li><li><a href="/search/?q=author%3AMacIntyre%2C%20Donald%20J">MacIntyre, Donald J</a>; </li><li><a href="/search/?q=author%3AMagnusson%2C%20Patrik%20KE">Magnusson, Patrik KE</a>; </li><li><a href="/search/?q=author%3AMaher%2C%20Brion%20S">Maher, Brion S</a>; </li><li><a href="/search/?q=author%3AMahon%2C%20Pamela%20B">Mahon, Pamela B</a>; </li><li><a href="/search/?q=author%3AMaier%2C%20Wolfgang">Maier, Wolfgang</a>; </li><li><a href="/search/?q=author%3AMalhotra%2C%20Anil%20K">Malhotra, Anil K</a>; </li><li><a href="/search/?q=author%3AMallet%2C%20Jacques">Mallet, Jacques</a>; </li><li><a href="/search/?q=author%3AMalt%2C%20Ulrik%20F">Malt, Ulrik F</a>; </li><li><a href="/search/?q=author%3AMarkus%2C%20Hugh%20S">Markus, Hugh S</a>; </li><li><a href="/search/?q=author%3AMarsal%2C%20Sara">Marsal, Sara</a>; </li><li><a href="/search/?q=author%3AMartin%2C%20Nicholas%20G">Martin, Nicholas G</a>; </li><li><a href="/search/?q=author%3AMata%2C%20Ignacio">Mata, Ignacio</a>; </li><li><a href="/search/?q=author%3AMathew%2C%20Christopher%20G">Mathew, Christopher G</a>; </li><li><a href="/search/?q=author%3AMattheisen%2C%20Manuel">Mattheisen, Manuel</a>; </li><li><a href="/search/?q=author%3AMattingsdal%2C%20Morten">Mattingsdal, Morten</a>; </li><li><a href="/search/?q=author%3AMayoral%2C%20Fermin">Mayoral, Fermin</a>; </li><li><a href="/search/?q=author%3AMcCann%2C%20Owen%20T">McCann, Owen T</a>; </li><li><a href="/search/?q=author%3AMcCarley%2C%20Robert%20W">McCarley, Robert W</a>; </li><li><a href="/search/?q=author%3AMcCarroll%2C%20Steven%20A">McCarroll, Steven A</a>; </li><li><a href="/search/?q=author%3AMcCarthy%2C%20Mark%20I">McCarthy, Mark I</a>; </li><li><a href="/search/?q=author%3AMcDonald%2C%20Colm">McDonald, Colm</a>; </li><li><a href="/search/?q=author%3AMcElroy%2C%20Susan%20L">McElroy, Susan L</a>; </li><li><a href="/search/?q=author%3AMcGuffin%2C%20Peter">McGuffin, Peter</a>; </li><li><a href="/search/?q=author%3AMcInnis%2C%20Melvin%20G">McInnis, Melvin G</a>; </li><li><a href="/search/?q=author%3AMcIntosh%2C%20Andrew%20M">McIntosh, Andrew M</a>; </li><li><a href="/search/?q=author%3AMcKay%2C%20James%20D">McKay, James D</a>; </li><li><a href="/search/?q=author%3AMcMahon%2C%20Francis%20J">McMahon, Francis J</a>; </li><li><a href="/search/?q=author%3AMedeiros%2C%20Helena">Medeiros, Helena</a>; </li><li><a href="/search/?q=author%3AMedland%2C%20Sarah%20E">Medland, Sarah E</a>; </li><li><a href="/search/?q=author%3AMeier%2C%20Sandra">Meier, Sandra</a>; </li><li><a href="/search/?q=author%3AMeijer%2C%20Carin%20J">Meijer, Carin J</a>; </li><li><a href="/search/?q=author%3AMelegh%2C%20Bela">Melegh, Bela</a>; </li><li><a href="/search/?q=author%3AMelle%2C%20Ingrid">Melle, Ingrid</a>; </li><li><a href="/search/?q=author%3AMeng%2C%20Fan">Meng, Fan</a>; </li><li><a href="/search/?q=author%3AMesholam-Gately%2C%20Raquelle%20I">Mesholam-Gately, Raquelle I</a>; </li><li><a href="/search/?q=author%3AMetspalu%2C%20Andres">Metspalu, Andres</a>; </li><li><a href="/search/?q=author%3AMichie%2C%20Patricia%20T">Michie, Patricia T</a>; </li><li><a href="/search/?q=author%3AMilani%2C%20Lili">Milani, Lili</a>; </li><li><a href="/search/?q=author%3AMilanova%2C%20Vihra">Milanova, Vihra</a>; </li><li><a href="/search/?q=author%3AMitchell%2C%20Philip%20B">Mitchell, Philip B</a>; </li><li><a href="/search/?q=author%3AMokrab%2C%20Younes">Mokrab, Younes</a>; </li><li><a href="/search/?q=author%3AMontgomery%2C%20Grant%20W">Montgomery, Grant W</a>; </li><li><a href="/search/?q=author%3AMoran%2C%20Jennifer%20L">Moran, Jennifer L</a>; </li><li><a href="/search/?q=author%3AMorken%2C%20Gunnar">Morken, Gunnar</a>; </li><li><a href="/search/?q=author%3AMorris%2C%20Derek%20W">Morris, Derek W</a>; </li><li><a href="/search/?q=author%3AMors%2C%20Ole">Mors, Ole</a>; </li><li><a href="/search/?q=author%3AMortensen%2C%20Preben%20B">Mortensen, Preben B</a>; </li><li><a href="/search/?q=author%3AMowry%2C%20Bryan%20J">Mowry, Bryan J</a>; </li><li><a href="/search/?q=author%3AM%C3%BChleisen%2C%20Thomas%20W">Mühleisen, Thomas W</a>; </li><li><a href="/search/?q=author%3AM%C3%BCller-Myhsok%2C%20Bertram">Müller-Myhsok, Bertram</a>; </li><li><a href="/search/?q=author%3AMurphy%2C%20Kieran%20C">Murphy, Kieran C</a>; </li><li><a href="/search/?q=author%3AMurray%2C%20Robin%20M">Murray, Robin M</a>; </li><li><a href="/search/?q=author%3AMyers%2C%20Richard%20M">Myers, Richard M</a>; </li><li><a href="/search/?q=author%3AMyin-Germeys%2C%20Inez">Myin-Germeys, Inez</a>; </li><li><a href="/search/?q=author%3ANeale%2C%20Benjamin%20M">Neale, Benjamin M</a>; </li><li><a href="/search/?q=author%3ANelis%2C%20Mari">Nelis, Mari</a>; </li><li><a href="/search/?q=author%3ANenadic%2C%20Igor">Nenadic, Igor</a>; </li><li><a href="/search/?q=author%3ANertney%2C%20Deborah%20A">Nertney, Deborah A</a>; </li><li><a href="/search/?q=author%3ANestadt%2C%20Gerald">Nestadt, Gerald</a>; </li><li><a href="/search/?q=author%3ANicodemus%2C%20Kristin%20K">Nicodemus, Kristin K</a>; </li><li><a href="/search/?q=author%3ANievergelt%2C%20Caroline%20M">Nievergelt, Caroline M</a>; </li><li><a href="/search/?q=author%3ANikitina-Zake%2C%20Liene">Nikitina-Zake, Liene</a>; </li><li><a href="/search/?q=author%3ANimgaonkar%2C%20Vishwajit">Nimgaonkar, Vishwajit</a>; </li><li><a href="/search/?q=author%3ANisenbaum%2C%20Laura">Nisenbaum, Laura</a>; </li><li><a href="/search/?q=author%3ANordentoft%2C%20Merete">Nordentoft, Merete</a>; </li><li><a href="/search/?q=author%3ANordin%2C%20Annelie">Nordin, Annelie</a>; </li><li><a href="/search/?q=author%3AN%C3%B6then%2C%20Markus%20M">Nöthen, Markus M</a>; </li><li><a href="/search/?q=author%3ANwulia%2C%20Evaristus%20A">Nwulia, Evaristus A</a>; </li><li><a href="/search/?q=author%3AO%E2%80%99Callaghan%2C%20Eadbhard">O’Callaghan, Eadbhard</a>; </li><li><a href="/search/?q=author%3AO%E2%80%99Donovan%2C%20Claire">O’Donovan, Claire</a>; </li><li><a href="/search/?q=author%3AO%E2%80%99Dushlaine%2C%20Colm">O’Dushlaine, Colm</a>; </li><li><a href="/search/?q=author%3AO%E2%80%99Neill%2C%20F%20Anthony">O’Neill, F Anthony</a>; </li><li><a href="/search/?q=author%3AOedegaard%2C%20Ketil%20J">Oedegaard, Ketil J</a>; </li><li><a href="/search/?q=author%3AOh%2C%20Sang-Yun">Oh, Sang-Yun</a>; </li><li><a href="/search/?q=author%3AOlincy%2C%20Ann">Olincy, Ann</a>; </li><li><a href="/search/?q=author%3AOlsen%2C%20Line">Olsen, Line</a>; </li><li><a href="/search/?q=author%3AOruc%2C%20Lilijana">Oruc, Lilijana</a>; </li><li><a href="/search/?q=author%3AVan%20Os%2C%20Jim">Van Os, Jim</a>; </li><li><a href="/search/?q=author%3AOwen%2C%20Michael%20J">Owen, Michael J</a>; </li><li><a href="/search/?q=author%3APaciga%2C%20Sara%20A">Paciga, Sara A</a>; </li><li><a href="/search/?q=author%3APalmer%2C%20Colin%20NA">Palmer, Colin NA</a>; </li><li><a href="/search/?q=author%3APalotie%2C%20Aarno">Palotie, Aarno</a>; </li><li><a href="/search/?q=author%3APantelis%2C%20Christos">Pantelis, Christos</a>; </li><li><a href="/search/?q=author%3APapadimitriou%2C%20George%20N">Papadimitriou, George N</a>; </li><li><a href="/search/?q=author%3AParkhomenko%2C%20Elena">Parkhomenko, Elena</a>; </li><li><a href="/search/?q=author%3APato%2C%20Carlos">Pato, Carlos</a>; </li><li><a href="/search/?q=author%3APato%2C%20Michele%20T">Pato, Michele T</a>; </li><li><a href="/search/?q=author%3APaunio%2C%20Tiina">Paunio, Tiina</a>; </li><li><a href="/search/?q=author%3APearson%2C%20Richard">Pearson, Richard</a>; </li><li><a href="/search/?q=author%3AConsortium%2C%20Psychosis%20Endophenotypes%20International">Consortium, Psychosis Endophenotypes International</a>; </li><li><a href="/search/?q=author%3APerkins%2C%20Diana%20O">Perkins, Diana O</a>; </li><li><a href="/search/?q=author%3APerlis%2C%20Roy%20H">Perlis, Roy H</a>; </li><li><a href="/search/?q=author%3APerry%2C%20Amy">Perry, Amy</a>; </li><li><a href="/search/?q=author%3APers%2C%20Tune%20H">Pers, Tune H</a>; </li><li><a href="/search/?q=author%3APetryshen%2C%20Tracey%20L">Petryshen, Tracey L</a>; </li><li><a href="/search/?q=author%3APfennig%2C%20Andrea">Pfennig, Andrea</a>; </li><li><a href="/search/?q=author%3APicchioni%2C%20Marco">Picchioni, Marco</a>; </li><li><a href="/search/?q=author%3APietilainen%2C%20Olli">Pietilainen, Olli</a>; </li><li><a href="/search/?q=author%3APimm%2C%20Jonathan">Pimm, Jonathan</a>; </li><li><a href="/search/?q=author%3APirinen%2C%20Matti">Pirinen, Matti</a>; </li><li><a href="/search/?q=author%3APlomin%2C%20Robert">Plomin, Robert</a>; </li><li><a href="/search/?q=author%3APocklington%2C%20Andrew%20J">Pocklington, Andrew J</a>; </li><li><a href="/search/?q=author%3APosthuma%2C%20Danielle">Posthuma, Danielle</a>; </li><li><a href="/search/?q=author%3APotash%2C%20James%20B">Potash, James B</a>; </li><li><a href="/search/?q=author%3APotter%2C%20Simon%20C">Potter, Simon C</a>; </li><li><a href="/search/?q=author%3APowell%2C%20John">Powell, John</a>; </li><li><a href="/search/?q=author%3APrice%2C%20Alkes">Price, Alkes</a>; </li><li><a href="/search/?q=author%3APulver%2C%20Ann%20E">Pulver, Ann E</a>; </li><li><a href="/search/?q=author%3APurcell%2C%20Shaun%20M">Purcell, Shaun M</a>; </li><li><a href="/search/?q=author%3AQuested%2C%20Digby">Quested, Digby</a>; </li><li><a href="/search/?q=author%3ARamos-Quiroga%2C%20Josep%20Antoni">Ramos-Quiroga, Josep Antoni</a>; </li><li><a href="/search/?q=author%3ARasmussen%2C%20Henrik%20B">Rasmussen, Henrik B</a>; </li><li><a href="/search/?q=author%3ARautanen%2C%20Anna">Rautanen, Anna</a>; </li><li><a href="/search/?q=author%3ARavindrarajah%2C%20Radhi">Ravindrarajah, Radhi</a>; </li><li><a href="/search/?q=author%3ARegeer%2C%20Eline%20J">Regeer, Eline J</a>; </li><li><a href="/search/?q=author%3AReichenberg%2C%20Abraham">Reichenberg, Abraham</a>; </li><li><a href="/search/?q=author%3AReif%2C%20Andreas">Reif, Andreas</a>; </li><li><a href="/search/?q=author%3AReimers%2C%20Mark%20A">Reimers, Mark A</a>; </li><li><a href="/search/?q=author%3ARibases%2C%20Marta">Ribases, Marta</a>; </li><li><a href="/search/?q=author%3ARice%2C%20John%20P">Rice, John P</a>; </li><li><a href="/search/?q=author%3ARichards%2C%20Alexander%20L">Richards, Alexander L</a>; </li><li><a href="/search/?q=author%3ARicketts%2C%20Michelle">Ricketts, Michelle</a>; </li><li><a href="/search/?q=author%3ARiley%2C%20Brien%20P">Riley, Brien P</a>; </li><li><a href="/search/?q=author%3ARivas%2C%20Fabio">Rivas, Fabio</a>; </li><li><a href="/search/?q=author%3ARivera%2C%20Margarita">Rivera, Margarita</a>; </li><li><a href="/search/?q=author%3ARoffman%2C%20Joshua%20L">Roffman, Joshua L</a>; </li><li><a href="/search/?q=author%3ARouleau%2C%20Guy%20A">Rouleau, Guy A</a>; </li><li><a href="/search/?q=author%3ARoussos%2C%20Panos">Roussos, Panos</a>; </li><li><a href="/search/?q=author%3ARujescu%2C%20Dan">Rujescu, Dan</a>; </li><li><a href="/search/?q=author%3ASalomaa%2C%20Veikko">Salomaa, Veikko</a>; </li><li><a href="/search/?q=author%3ASanchez-Mora%2C%20Cristina">Sanchez-Mora, Cristina</a>; </li><li><a href="/search/?q=author%3ASanders%2C%20Alan%20R">Sanders, Alan R</a>; </li><li><a href="/search/?q=author%3ASawcer%2C%20Stephen%20J">Sawcer, Stephen J</a>; </li><li><a href="/search/?q=author%3ASchall%2C%20Ulrich">Schall, Ulrich</a>; </li><li><a href="/search/?q=author%3ASchatzberg%2C%20Alan%20F">Schatzberg, Alan F</a>; </li><li><a href="/search/?q=author%3AScheftner%2C%20William%20A">Scheftner, William A</a>; </li><li><a href="/search/?q=author%3ASchofield%2C%20Peter%20R">Schofield, Peter R</a>; </li><li><a href="/search/?q=author%3ASchork%2C%20Nicholas%20J">Schork, Nicholas J</a>; </li><li><a href="/search/?q=author%3ASchwab%2C%20Sibylle%20G">Schwab, Sibylle G</a>; </li><li><a href="/search/?q=author%3AScolnick%2C%20Edward%20M">Scolnick, Edward M</a>; </li><li><a href="/search/?q=author%3AScott%2C%20Laura%20J">Scott, Laura J</a>; </li><li><a href="/search/?q=author%3AScott%2C%20Rodney%20J">Scott, Rodney J</a>; </li><li><a href="/search/?q=author%3ASeidman%2C%20Larry%20J">Seidman, Larry J</a>; </li><li><a href="/search/?q=author%3ASerretti%2C%20Alessandro">Serretti, Alessandro</a>; </li><li><a href="/search/?q=author%3ASham%2C%20Pak%20C">Sham, Pak C</a>; </li><li><a href="/search/?q=author%3AWeickert%2C%20Cynthia%20Shannon">Weickert, Cynthia Shannon</a>; </li><li><a href="/search/?q=author%3AShehktman%2C%20Tatyana">Shehktman, Tatyana</a>; </li><li><a href="/search/?q=author%3AShi%2C%20Jianxin">Shi, Jianxin</a>; </li><li><a href="/search/?q=author%3AShilling%2C%20Paul%20D">Shilling, Paul D</a>; </li><li><a href="/search/?q=author%3ASigurdsson%2C%20Engilbert">Sigurdsson, Engilbert</a>; </li><li><a href="/search/?q=author%3ASilverman%2C%20Jeremy%20M">Silverman, Jeremy M</a>; </li><li><a href="/search/?q=author%3ASim%2C%20Kang">Sim, Kang</a>; </li><li><a href="/search/?q=author%3ASlaney%2C%20Claire">Slaney, Claire</a>; </li><li><a href="/search/?q=author%3ASlominsky%2C%20Petr">Slominsky, Petr</a>; </li><li><a href="/search/?q=author%3ASmeland%2C%20Olav%20B">Smeland, Olav B</a>; </li><li><a href="/search/?q=author%3ASmoller%2C%20Jordan%20W">Smoller, Jordan W</a>; </li><li><a href="/search/?q=author%3ASo%2C%20Hon-Cheong">So, Hon-Cheong</a>; </li><li><a href="/search/?q=author%3ASobell%2C%20Janet%20L">Sobell, Janet L</a>; </li><li><a href="/search/?q=author%3ASoderman%2C%20Erik">Soderman, Erik</a>; </li><li><a href="/search/?q=author%3AHansen%2C%20Christine%20Soholm">Hansen, Christine Soholm</a>; </li><li><a href="/search/?q=author%3ASpencer%2C%20Chris%20CA">Spencer, Chris CA</a>; </li><li><a href="/search/?q=author%3ASpijker%2C%20Anne%20T">Spijker, Anne T</a>; </li><li><a href="/search/?q=author%3ASt%20Clair%2C%20David">St Clair, David</a>; </li><li><a href="/search/?q=author%3AStefansson%2C%20Hreinn">Stefansson, Hreinn</a>; </li><li><a href="/search/?q=author%3AStefansson%2C%20Kari">Stefansson, Kari</a>; </li><li><a href="/search/?q=author%3ASteinberg%2C%20Stacy">Steinberg, Stacy</a>; </li><li><a href="/search/?q=author%3AStogmann%2C%20Elisabeth">Stogmann, Elisabeth</a>; </li><li><a href="/search/?q=author%3AStordal%2C%20Eystein">Stordal, Eystein</a>; </li><li><a href="/search/?q=author%3AStrange%2C%20Amy">Strange, Amy</a>; </li><li><a href="/search/?q=author%3AStraub%2C%20Richard%20E">Straub, Richard E</a>; </li><li><a href="/search/?q=author%3AStrauss%2C%20John%20S">Strauss, John S</a>; </li><li><a href="/search/?q=author%3AStreit%2C%20Fabian">Streit, Fabian</a>; </li><li><a href="/search/?q=author%3AStrengman%2C%20Eric">Strengman, Eric</a>; </li><li><a href="/search/?q=author%3AStrohmaier%2C%20Jana">Strohmaier, Jana</a>; </li><li><a href="/search/?q=author%3AStroup%2C%20T%20Scott">Stroup, T Scott</a>; </li><li><a href="/search/?q=author%3ASu%2C%20Zhan">Su, Zhan</a>; </li><li><a href="/search/?q=author%3ASubramaniam%2C%20Mythily">Subramaniam, Mythily</a>; </li><li><a href="/search/?q=author%3ASuvisaari%2C%20Jaana">Suvisaari, Jaana</a>; </li><li><a href="/search/?q=author%3ASvrakic%2C%20Dragan%20M">Svrakic, Dragan M</a>; </li><li><a href="/search/?q=author%3ASzatkiewicz%2C%20Jin%20P">Szatkiewicz, Jin P</a>; </li><li><a href="/search/?q=author%3ASzelinger%2C%20Szabolcs">Szelinger, Szabolcs</a>; </li><li><a href="/search/?q=author%3ATashakkori-Ghanbaria%2C%20Avazeh">Tashakkori-Ghanbaria, Avazeh</a>; </li><li><a href="/search/?q=author%3AThirumalai%2C%20Srinivas">Thirumalai, Srinivas</a>; </li><li><a href="/search/?q=author%3AThompson%2C%20Robert%20C">Thompson, Robert C</a>; </li><li><a href="/search/?q=author%3AThorgeirsson%2C%20Thorgeir%20E">Thorgeirsson, Thorgeir E</a>; </li><li><a href="/search/?q=author%3AToncheva%2C%20Draga">Toncheva, Draga</a>; </li><li><a href="/search/?q=author%3ATooney%2C%20Paul%20A">Tooney, Paul A</a>; </li><li><a href="/search/?q=author%3ATosato%2C%20Sarah">Tosato, Sarah</a>; </li><li><a href="/search/?q=author%3AToulopoulou%2C%20Timothea">Toulopoulou, Timothea</a>; </li><li><a href="/search/?q=author%3ATrembath%2C%20Richard%20C">Trembath, Richard C</a>; </li><li><a href="/search/?q=author%3ATreutlein%2C%20Jens">Treutlein, Jens</a>; </li><li><a href="/search/?q=author%3ATurecki%2C%20Gustavo">Turecki, Gustavo</a>; </li><li><a href="/search/?q=author%3AVaaler%2C%20Arne%20E">Vaaler, Arne E</a>; </li><li><a href="/search/?q=author%3AVedder%2C%20Helmut">Vedder, Helmut</a>; </li><li><a href="/search/?q=author%3AVieta%2C%20Eduard">Vieta, Eduard</a>; </li><li><a href="/search/?q=author%3AVincent%2C%20John">Vincent, John</a>; </li><li><a href="/search/?q=author%3AVisscher%2C%20Peter%20M">Visscher, Peter M</a>; </li><li><a href="/search/?q=author%3AViswanathan%2C%20Ananth%20C">Viswanathan, Ananth C</a>; </li><li><a href="/search/?q=author%3AVukcevic%2C%20Damjan">Vukcevic, Damjan</a>; </li><li><a href="/search/?q=author%3AWaddington%2C%20John">Waddington, John</a>; </li><li><a href="/search/?q=author%3AWaller%2C%20Matthew">Waller, Matthew</a>; </li><li><a href="/search/?q=author%3AWalsh%2C%20Dermot">Walsh, Dermot</a>; </li><li><a href="/search/?q=author%3AWalshe%2C%20Muriel">Walshe, Muriel</a>; </li><li><a href="/search/?q=author%3AWalters%2C%20James%20TR">Walters, James TR</a>; </li><li><a href="/search/?q=author%3AWang%2C%20Dai">Wang, Dai</a>; </li><li><a href="/search/?q=author%3AWang%2C%20Qiang">Wang, Qiang</a>; </li><li><a href="/search/?q=author%3AWang%2C%20Weiqing">Wang, Weiqing</a>; </li><li><a href="/search/?q=author%3AWang%2C%20Yunpeng">Wang, Yunpeng</a>; </li><li><a href="/search/?q=author%3AWatson%2C%20Stanley%20J">Watson, Stanley J</a>; </li><li><a href="/search/?q=author%3AWebb%2C%20Bradley%20T">Webb, Bradley T</a>; </li><li><a href="/search/?q=author%3AWeickert%2C%20Thomas%20W">Weickert, Thomas W</a>; </li><li><a href="/search/?q=author%3AWeinberger%2C%20Daniel%20R">Weinberger, Daniel R</a>; </li><li><a href="/search/?q=author%3AWeisbrod%2C%20Matthias">Weisbrod, Matthias</a>; </li><li><a href="/search/?q=author%3AWeiser%2C%20Mark">Weiser, Mark</a>; </li><li><a href="/search/?q=author%3AWerge%2C%20Thomas">Werge, Thomas</a>; </li><li><a href="/search/?q=author%3AWeston%2C%20Paul">Weston, Paul</a>; </li><li><a href="/search/?q=author%3AWhittaker%2C%20Pamela">Whittaker, Pamela</a>; </li><li><a href="/search/?q=author%3AWidaa%2C%20Sara">Widaa, Sara</a>; </li><li><a href="/search/?q=author%3AWiersma%2C%20Durk">Wiersma, Durk</a>; </li><li><a href="/search/?q=author%3AWildenauer%2C%20Dieter%20B">Wildenauer, Dieter B</a>; </li><li><a href="/search/?q=author%3AWilliams%2C%20Nigel%20M">Williams, Nigel M</a>; </li><li><a href="/search/?q=author%3AWilliams%2C%20Stephanie">Williams, Stephanie</a>; </li><li><a href="/search/?q=author%3AWitt%2C%20Stephanie%20H">Witt, Stephanie H</a>; </li><li><a href="/search/?q=author%3AWolen%2C%20Aaron%20R">Wolen, Aaron R</a>; </li><li><a href="/search/?q=author%3AWong%2C%20Emily%20HM">Wong, Emily HM</a>; </li><li><a href="/search/?q=author%3AWood%2C%20Nicholas%20W">Wood, Nicholas W</a>; </li><li><a href="/search/?q=author%3AWormley%2C%20Brandon%20K">Wormley, Brandon K</a>; </li><li><a href="/search/?q=author%3AConsortium%2C%20Wellcome%20Trust%20Case-Control">Consortium, Wellcome Trust Case-Control</a>; </li><li><a href="/search/?q=author%3AWu%2C%20Jing%20Qin">Wu, Jing Qin</a>; </li><li><a href="/search/?q=author%3AXi%2C%20Simon">Xi, Simon</a>; </li><li><a href="/search/?q=author%3AXu%2C%20Wei">Xu, Wei</a>; </li><li><a href="/search/?q=author%3AYoung%2C%20Allan%20H">Young, Allan H</a>; </li><li><a href="/search/?q=author%3AZai%2C%20Clement%20C">Zai, Clement C</a>; </li><li><a href="/search/?q=author%3AZandi%2C%20Peter">Zandi, Peter</a>; </li><li><a href="/search/?q=author%3AZhang%2C%20Peng">Zhang, Peng</a>; </li><li><a href="/search/?q=author%3AZheng%2C%20Xuebin">Zheng, Xuebin</a>; </li><li><a href="/search/?q=author%3AZimprich%2C%20Fritz">Zimprich, Fritz</a>; </li><li><a href="/search/?q=author%3AZollner%2C%20Sebastian">Zollner, Sebastian</a>; </li><li><a href="/search/?q=author%3ACorvin%2C%20Aiden">Corvin, Aiden</a>; </li><li><a href="/search/?q=author%3AFanous%2C%20Ayman%20H">Fanous, Ayman H</a>; </li><li><a href="/search/?q=author%3ACichon%2C%20Sven">Cichon, Sven</a>; </li><li><a href="/search/?q=author%3ARietschel%2C%20Marcella">Rietschel, Marcella</a>; </li><li><a href="/search/?q=author%3AGershon%2C%20Elliot%20S">Gershon, Elliot S</a>; </li><li><a href="/search/?q=author%3ASchulze%2C%20Thomas%20G">Schulze, Thomas G</a>; </li><li><a href="/search/?q=author%3ACuellar-Barboza%2C%20Alfredo%20B">Cuellar-Barboza, Alfredo B</a>; </li><li><a href="/search/?q=author%3AForstner%2C%20Andreas%20J">Forstner, Andreas J</a>; </li><li><a href="/search/?q=author%3AHolmans%2C%20Peter%20A">Holmans, Peter A</a>; </li><li><a href="/search/?q=author%3ANurnberger%2C%20John%20I">Nurnberger, John I</a>; </li><li><a href="/search/?q=author%3AAndreassen%2C%20Ole%20A">Andreassen, Ole A</a>; </li><li><a href="/search/?q=author%3ALee%2C%20S%20Hong">Lee, S Hong</a>; </li><li><a href="/search/?q=author%3AO%E2%80%99Donovan%2C%20Michael%20C">O’Donovan, Michael C</a>; </li><li><a href="/search/?q=author%3ASullivan%2C%20Patrick%20F">Sullivan, Patrick F</a>; </li><li><a href="/search/?q=author%3AOphoff%2C%20Roel%20A">Ophoff, Roel A</a>; </li><li><a href="/search/?q=author%3AWray%2C%20Naomi%20R">Wray, Naomi R</a>; </li><li><a href="/search/?q=author%3ASklar%2C%20Pamela">Sklar, Pamela</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3AKendler%2C%20Kenneth%20S">Kendler, Kenneth S</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucla_postprints">UCLA Previously Published Works</a> (2018)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup">Schizophrenia and bipolar disorder are two distinct diagnoses that share symptomology. Understanding the genetic factors contributing to the shared and disorder-specific symptoms will be crucial for improving diagnosis and treatment. In genetic data consisting of 53,555 cases (20,129 bipolar disorder [BD], 33,426 schizophrenia [SCZ]) and 54,065 controls, we identified 114 genome-wide significant loci implicating synaptic and neuronal pathways shared between disorders. Comparing SCZ to BD (23,585 SCZ, 15,270 BD) identified four genomic regions including one with disorder-independent causal variants and potassium ion response genes as contributing to differences in biology between the disorders. Polygenic risk score (PRS) analyses identified several significant correlations within case-only phenotypes including SCZ PRS with psychotic features and age of onset in BD. For the first time, we discover specific loci that distinguish between BD and SCZ and identify polygenic components underlying multiple symptom dimensions. These results point to the utility of genetics to inform symptomology and potential treatment.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div></section><nav class="c-pagination"><ul><li><a href="" aria-label="you are on result set 1" class="c-pagination__item--current">1</a></li><li><a href="" aria-label="go to result set 2" class="c-pagination__item">2</a></li></ul></nav></section></main></form></div><div><div class="c-toplink"><a href="javascript:window.scrollTo(0, 0)">Top</a></div><footer class="c-footer"><nav class="c-footer__nav"><ul><li><a href="/">Home</a></li><li><a href="/aboutEschol">About eScholarship</a></li><li><a href="/campuses">Campus Sites</a></li><li><a href="/ucoapolicies">UC Open Access Policy</a></li><li><a href="/publishing">eScholarship Publishing</a></li><li><a href="https://www.cdlib.org/about/accessibility.html">Accessibility</a></li><li><a href="/privacypolicy">Privacy Statement</a></li><li><a href="/policies">Site Policies</a></li><li><a href="/terms">Terms of Use</a></li><li><a href="/login"><strong>Admin Login</strong></a></li><li><a href="https://help.escholarship.org"><strong>Help</strong></a></li></ul></nav><div class="c-footer__logo"><a href="/"><img class="c-lazyimage" data-src="/images/logo_footer-eschol.svg" alt="eScholarship, University of California"/></a></div><div class="c-footer__copyright">Powered by the<br/><a href="http://www.cdlib.org">California Digital Library</a><br/>Copyright © 2017<br/>The Regents of the University of California</div></footer></div></div></div></div> <script src="/js/vendors~app-bundle-2aefc956e545366a5d4e.js"></script> <script src="/js/app-bundle-4477d7630fb8c6f70662.js"></script> </body> </html>