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antisolvent</title> <meta name="description" content="Search results for: antisolvent"> <meta name="keywords" content="antisolvent"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler 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id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="antisolvent"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 12</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: antisolvent</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">12</span> Number of Perovskite Layers and the Effect of Antisolvent on Perovskite Solar Cell Efficiency</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ece%20%C3%87etin">Ece Çetin</a>, <a href="https://publications.waset.org/abstracts/search?q=%C4%B0smail%20Boz"> İsmail Boz</a>, <a href="https://publications.waset.org/abstracts/search?q=Mehtap%20%C5%9Eafak%20Boro%C4%9Flu"> Mehtap Şafak Boroğlu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Energy is one of the most important components of production processes, economic activities, and daily life. Non-renewable energy sources cause serious environmental problems with the increase of greenhouse gases. Obtaining energy from renewable sources is also essential for sustainable economic growth. Solar energy is also an important renewable energy source with its unlimited and clean features. In this study, the effect of 1, 2, and 3 layers of perovskite film number and antisolvent dripping on perovskite based solar cell efficiency was investigated. The yield increased as the number of perovskite films increased. In addition, the yields obtained with the antisolvent dripped in the last 5 seconds are higher than the ones dropped in the last 17 seconds. The highest efficiency was obtained with 3 perovskite films, and antisolvent dropped in the last 5 seconds. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antisolvent" title="antisolvent">antisolvent</a>, <a href="https://publications.waset.org/abstracts/search?q=efficiency" title=" efficiency"> efficiency</a>, <a href="https://publications.waset.org/abstracts/search?q=perovskite" title=" perovskite"> perovskite</a>, <a href="https://publications.waset.org/abstracts/search?q=solar%20cell" title=" solar cell"> solar cell</a> </p> <a href="https://publications.waset.org/abstracts/155240/number-of-perovskite-layers-and-the-effect-of-antisolvent-on-perovskite-solar-cell-efficiency" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/155240.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">109</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">11</span> Improving the Dissolution Rate of Folic Acid via the Antisolvent Vapour Precipitation</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=J.%20Y.%20Tan">J. Y. Tan</a>, <a href="https://publications.waset.org/abstracts/search?q=L.%20C.%20Lum"> L. C. Lum</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20G.%20Lee"> M. G. Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Mansouri"> S. Mansouri</a>, <a href="https://publications.waset.org/abstracts/search?q=K.%20Hapgood"> K. Hapgood</a>, <a href="https://publications.waset.org/abstracts/search?q=X.%20D.%20Chen"> X. D. Chen</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20W.%20Woo"> M. W. Woo </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Folic acid (FA) is known to be an important supplement to prevent neural tube defect (NTD) in pregnant women. Similar to some commercial formulations, sodium bicarbonate solution is used as a solvent for FA. This work uses the antisolvent vapor precipitation (AVP), incorporating ethanol vapor as the convective drying medium in place of air to produce branch-like micro-structure FA particles. Interestingly, the dissolution rate of the resultant particle is 2-3 times better than the particle produce from conventional air drying due to the higher surface area of particles produced. The higher dissolution rate could possibly improve the delivery and absorption of FA in human body. This application could potentially be extended to other commercial products, particularly in less soluble drugs to improve its solubility. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=absorption" title="absorption">absorption</a>, <a href="https://publications.waset.org/abstracts/search?q=antisolvent%20vapor%20precipitation" title=" antisolvent vapor precipitation"> antisolvent vapor precipitation</a>, <a href="https://publications.waset.org/abstracts/search?q=dissolution%20rate" title=" dissolution rate"> dissolution rate</a>, <a href="https://publications.waset.org/abstracts/search?q=folic%20acid" title=" folic acid"> folic acid</a> </p> <a href="https://publications.waset.org/abstracts/17084/improving-the-dissolution-rate-of-folic-acid-via-the-antisolvent-vapour-precipitation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/17084.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">445</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">10</span> Studies on the Applicability of Artificial Neural Network (ANN) in Prediction of Thermodynamic Behavior of Sodium Chloride Aqueous System Containing a Non-Electrolytes</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Dariush%20Jafari">Dariush Jafari</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Mostafa%20Nowee"> S. Mostafa Nowee</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this study a ternary system containing sodium chloride as solute, water as primary solvent and ethanol as the antisolvent was considered to investigate the application of artificial neural network (ANN) in prediction of sodium solubility in the mixture of water as the solvent and ethanol as the antisolvent. The system was previously studied using by Extended UNIQUAC model by the authors of this study. The comparison between the results of the two models shows an excellent agreement between them (R2=0.99), and also approves the capability of ANN to predict the thermodynamic behavior of ternary electrolyte systems which are difficult to model. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=thermodynamic%20modeling" title="thermodynamic modeling">thermodynamic modeling</a>, <a href="https://publications.waset.org/abstracts/search?q=ANN" title=" ANN"> ANN</a>, <a href="https://publications.waset.org/abstracts/search?q=solubility" title=" solubility"> solubility</a>, <a href="https://publications.waset.org/abstracts/search?q=ternary%20electrolyte%20system" title=" ternary electrolyte system"> ternary electrolyte system</a> </p> <a href="https://publications.waset.org/abstracts/18933/studies-on-the-applicability-of-artificial-neural-network-ann-in-prediction-of-thermodynamic-behavior-of-sodium-chloride-aqueous-system-containing-a-non-electrolytes" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/18933.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">385</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">9</span> Mechanisms Leading to the Protective Behavior of Ethanol Vapour Drying of Probiotics </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Shahnaz%20Mansouri">Shahnaz Mansouri</a>, <a href="https://publications.waset.org/abstracts/search?q=Xiao%20Dong%20Chen"> Xiao Dong Chen</a>, <a href="https://publications.waset.org/abstracts/search?q=Meng%20Wai%20Woo"> Meng Wai Woo</a> </p> <p class="card-text"><strong>Abstract:</strong></p> A new antisolvent vapour precipitation approach was used to make ultrafine submicron probiotic encapsulates. The approach uses ethanol vapour to precipitate submicron encapsulates within relatively large droplets. Surprisingly, the probiotics (Lactobacillus delbrueckii ssp. bulgaricus, Streptococcus thermophilus) showed relatively high survival even under destructive ethanolic conditions within the droplet. This unusual behaviour was deduced to be caused by the denaturation and aggregation of the milk protein forming an ethanolic protective matrix for the probiotics. Skim milk droplets which is rich in casein and contains naturally occurring minerals provided higher ethanolic protection when compared whey protein isolate and lactose droplets. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=whey" title="whey">whey</a>, <a href="https://publications.waset.org/abstracts/search?q=skim%20milk" title=" skim milk"> skim milk</a>, <a href="https://publications.waset.org/abstracts/search?q=probiotic" title=" probiotic"> probiotic</a>, <a href="https://publications.waset.org/abstracts/search?q=antisolvent" title=" antisolvent"> antisolvent</a>, <a href="https://publications.waset.org/abstracts/search?q=precipitation" title=" precipitation"> precipitation</a>, <a href="https://publications.waset.org/abstracts/search?q=encapsulation" title=" encapsulation"> encapsulation</a>, <a href="https://publications.waset.org/abstracts/search?q=denaturation" title=" denaturation"> denaturation</a>, <a href="https://publications.waset.org/abstracts/search?q=aggregation" title=" aggregation"> aggregation</a> </p> <a href="https://publications.waset.org/abstracts/22431/mechanisms-leading-to-the-protective-behavior-of-ethanol-vapour-drying-of-probiotics" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/22431.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">522</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">8</span> Ultrafine Non Water Soluble Drug Particles</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Shahnaz%20Mansouri">Shahnaz Mansouri</a>, <a href="https://publications.waset.org/abstracts/search?q=David%20Martin"> David Martin</a>, <a href="https://publications.waset.org/abstracts/search?q=Xiao%20Dong%20Chen"> Xiao Dong Chen</a>, <a href="https://publications.waset.org/abstracts/search?q=Meng%20Wai%20Woo"> Meng Wai Woo</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Ultrafine hydrophobic and non-water-soluble drugs can increase the percentage of absorbed compared to their initial dosage. This paper provides a scalable new method of making ultrafine particles of substantially insoluble water compounds specifically, submicron particles of ethanol soluble and water insoluble pharmaceutical materials by steaming an ethanol droplet to prepare a suspension and then followed by immediate drying. This suspension is formed by adding evaporated water molecules as an anti-solvent to the solute of the samples and in early stage of precipitation continued to dry by evaporating both solvent and anti-solvent. This fine particle formation has produced fast dispersion powder in water. The new method is an extension of the antisolvent vapour precipitation technique which exposes a droplet to an antisolvent vapour with reference to the dissolved materials within the droplet. Ultrafine vitamin D3 and ibuprofen particles in the submicron ranges were produced. This work will form the basis for using spray dryers as high-throughput scalable micro-precipitators. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=single%20droplet%20drying" title="single droplet drying">single droplet drying</a>, <a href="https://publications.waset.org/abstracts/search?q=nano%20size%20particles" title=" nano size particles"> nano size particles</a>, <a href="https://publications.waset.org/abstracts/search?q=non-water-soluble%20drugs" title=" non-water-soluble drugs"> non-water-soluble drugs</a>, <a href="https://publications.waset.org/abstracts/search?q=precipitators" title=" precipitators"> precipitators</a> </p> <a href="https://publications.waset.org/abstracts/19314/ultrafine-non-water-soluble-drug-particles" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/19314.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">483</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7</span> Towards a Rigorous Analysis for a Supercritical Particulate Process</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Yousef%20Bakhbakhi">Yousef Bakhbakhi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Crystallization with supercritical fluids (SCFs), as a developed technology to produce particles of micron and sub-micron size with narrow size distribution, has found appreciable importance as an environmentally friendly technology. Particle synthesis using SCFs can be achieved employing a number of special processes involving solvent and antisolvent mechanisms. In this study, the compressed antisolvent (PCA) process is utilized as a model to analyze the theoretical complexity of crystallization with supercritical fluids. The population balance approach has proven to be an effectual technique to simulate and predict the particle size and size distribution. The nucleation and growth mechanisms of the particles formation in the PCA process is investigated using the population balance equation, which describes the evolution of the particle through coalescence and breakup levels with time. The employed mathematical population balance model contains a set of the partial differential equation with algebraic constraints, which demands a rigorous numerical approach. The combined Collocation and Galerkin finite element method are proposed as a high-resolution technique to solve the dynamics of the PCA process. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=particle%20formation" title="particle formation">particle formation</a>, <a href="https://publications.waset.org/abstracts/search?q=particle%20size%20and%20size%20distribution" title=" particle size and size distribution"> particle size and size distribution</a>, <a href="https://publications.waset.org/abstracts/search?q=PCA" title=" PCA"> PCA</a>, <a href="https://publications.waset.org/abstracts/search?q=supercritical%20carbon%20dioxide" title=" supercritical carbon dioxide"> supercritical carbon dioxide</a> </p> <a href="https://publications.waset.org/abstracts/89209/towards-a-rigorous-analysis-for-a-supercritical-particulate-process" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/89209.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">197</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">6</span> Synthesis of Biopolymeric Nanoparticles of Starch for Packaging Reinforcement Applications</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Yousof%20Farrag">Yousof Farrag</a>, <a href="https://publications.waset.org/abstracts/search?q=Sara%20Malmir"> Sara Malmir</a>, <a href="https://publications.waset.org/abstracts/search?q=Rebeca%20Bouza"> Rebeca Bouza</a>, <a href="https://publications.waset.org/abstracts/search?q=Maite%20Rico"> Maite Rico</a>, <a href="https://publications.waset.org/abstracts/search?q=Bel%C3%A9n%20Montero"> Belén Montero</a>, <a href="https://publications.waset.org/abstracts/search?q=Lu%C3%ADs%20Barral"> Luís Barral</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Biopolymers are being extensively studied in the last years as a replacement of the conventional petroleum derived polymers, especially in packaging industry. They are natural, biodegradable materials. However, the lack of good mechanical and barrier properties is a problem in the way of this replacement. One of the most abundant biopolymers in the nature is the starch, its renewable, biocompatible low cost polysaccharide, it can be obtained from wide variety of plants, it has been used in food, packaging and other industries. This work is focusing on the production a high yield of starch nanoparticles via nanoprecipitation, to be used as reinforcement filling of biopolymer packaging matrices made of different types of starch improving their mechanical and barrier properties. Wheat and corn starch solutions were prepared in different concentrations. Absolute ethanol, acetone and different concentrations of hydrochloric acid were added as antisolvents dropwise under different amplitudes of sonication and different speeds of stirring, the produced particles were analyzed with dynamic light scattering DLS and scanning electron microscope SEM getting the morphology and the size distribution to study the effect of those factors on the produced particles. DLS results show that we have nanoparticles using low concentration of corn starch (0.5%) using 0.1M HCl as antisolvent, [Z average: 209 nm, PDI: 0,49], in case of wheat starch, we could obtain nanoparticles [Z average: 159 nm, PDI: 0,45] using the same starch solution concentration together with absolute ethanol as antisolvent. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=biopolymers" title="biopolymers">biopolymers</a>, <a href="https://publications.waset.org/abstracts/search?q=nanoparticles" title=" nanoparticles"> nanoparticles</a>, <a href="https://publications.waset.org/abstracts/search?q=DLS" title=" DLS"> DLS</a>, <a href="https://publications.waset.org/abstracts/search?q=starch" title=" starch"> starch</a> </p> <a href="https://publications.waset.org/abstracts/45014/synthesis-of-biopolymeric-nanoparticles-of-starch-for-packaging-reinforcement-applications" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/45014.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">327</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5</span> Preparation of Polylactide Nanoparticles by Supercritical Fluid Technology</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jakub%20Z%C3%A1gora">Jakub Zágora</a>, <a href="https://publications.waset.org/abstracts/search?q=Daniela%20Plach%C3%A1"> Daniela Plachá</a>, <a href="https://publications.waset.org/abstracts/search?q=Karla%20%C4%8Cech%20Barabaszov%C3%A1"> Karla Čech Barabaszová</a>, <a href="https://publications.waset.org/abstracts/search?q=Sylva%20Hole%C5%A1ov%C3%A1"> Sylva Holešová</a>, <a href="https://publications.waset.org/abstracts/search?q=Roman%20G%C3%A1bor"> Roman Gábor</a>, <a href="https://publications.waset.org/abstracts/search?q=Alexandra%20Mu%C3%B1oz%20Bonilla"> Alexandra Muñoz Bonilla</a>, <a href="https://publications.waset.org/abstracts/search?q=Marta%20Fern%C3%A1ndez%20Garc%C3%ADa"> Marta Fernández García</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The development of new antimicrobial materials that are not toxic to higher living organisms is a major challenge today. Newly developed materials can have high application potential in biomedicine, coatings, packaging, etc. A combination of commonly used biopolymer polylactide with cationic polymers seems to be very successful in the fight against antimicrobial resistance [1].PLA will play a key role in fulfilling the intention set out in the New Deal announced by the EU commission, as it is a bioplastic that is easily degradable, recyclable, and mass-produced. Also, the development of 3D printing in the context of this initiative, and the actual use of PLA as one of the main materials used for this printing, make the technology around the preparation and modification of PLA quite logical. Moreover, theenvironmentally friendly and energy saving technology like supercritical fluid process (SFP) will be used for their preparation. In a first approach, polylactide nano- and microparticles and structures were prepared by supercritical fluid extraction. The RESS (rapid expansion supercritical fluid solution) method is easier to optimize and shows better particle size control. On the contrary, a highly porous structure was obtained using the SAS (supercritical antisolvent) method. In a second part, the antimicrobial biobased polymer was introduced by SFP. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=polylactide" title="polylactide">polylactide</a>, <a href="https://publications.waset.org/abstracts/search?q=antimicrobial%20polymers" title=" antimicrobial polymers"> antimicrobial polymers</a>, <a href="https://publications.waset.org/abstracts/search?q=supercritical%20fluid%20technology" title=" supercritical fluid technology"> supercritical fluid technology</a>, <a href="https://publications.waset.org/abstracts/search?q=micronization" title=" micronization"> micronization</a> </p> <a href="https://publications.waset.org/abstracts/142773/preparation-of-polylactide-nanoparticles-by-supercritical-fluid-technology" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/142773.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">188</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4</span> Experimental Design for Formulation Optimization of Nanoparticle of Cilnidipine</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Arti%20Bagada">Arti Bagada</a>, <a href="https://publications.waset.org/abstracts/search?q=Kantilal%20Vadalia"> Kantilal Vadalia</a>, <a href="https://publications.waset.org/abstracts/search?q=Mihir%20Raval"> Mihir Raval</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Cilnidipine is practically insoluble in water which results in its insufficient oral bioavailability. The purpose of the present investigation was to formulate cilnidipine nanoparticles by nanoprecipitation method to increase the aqueous solubility and dissolution rate and hence bioavailability by utilizing various experimental statistical design modules. Experimental design were used to investigate specific effects of independent variables during preparation cilnidipine nanoparticles and corresponding responses in optimizing the formulation. Plackett Burman design for independent variables was successfully employed for optimization of nanoparticles of cilnidipine. The influence of independent variables studied were drug concentration, solvent to antisolvent ratio, polymer concentration, stabilizer concentration and stirring speed. The dependent variables namely average particle size, polydispersity index, zeta potential value and saturation solubility of the formulated nanoparticles of cilnidipine. The experiments were carried out according to 13 runs involving 5 independent variables (higher and lower levels) employing Plackett-Burman design. The cilnidipine nanoparticles were characterized by average particle size, polydispersity index value, zeta potential value and saturation solubility and it results were 149 nm, 0.314, 43.24 and 0.0379 mg/ml, respectively. The experimental results were good correlated with predicted data analysed by Plackett-Burman statistical method. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=dissolution%20enhancement" title="dissolution enhancement">dissolution enhancement</a>, <a href="https://publications.waset.org/abstracts/search?q=nanoparticles" title=" nanoparticles"> nanoparticles</a>, <a href="https://publications.waset.org/abstracts/search?q=Plackett-Burman%20design" title=" Plackett-Burman design"> Plackett-Burman design</a>, <a href="https://publications.waset.org/abstracts/search?q=nanoprecipitation" title=" nanoprecipitation"> nanoprecipitation</a> </p> <a href="https://publications.waset.org/abstracts/81639/experimental-design-for-formulation-optimization-of-nanoparticle-of-cilnidipine" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/81639.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">159</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3</span> Nanoprecipitation with Ultrasonication for Enhancement of Oral Bioavailability of Fursemide: Pharmacokinetics and Pharmacodynamics Study in Rat Model</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Malay%20K.%20Das">Malay K. Das</a>, <a href="https://publications.waset.org/abstracts/search?q=Bhanu%20P.%20Sahu"> Bhanu P. Sahu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Furosemide is a weakly acidic diuretic indicated for treatment of edema and hypertension. It has very poor solubility but high permeability through stomach and upper gastrointestinal tract (GIT). Due to its limited solubility it has poor and variable oral bioavailability of 10-90%. The aim of this study was to enhance the oral bioavailability of furosemide by preparation of nanosuspensions. The nanosuspensions were prepared by nanoprecipitation with sonication using DMSO (dimethyl sulfoxide) as a solvent and water as an antisolvent (NA). The prepared nanosuspensions were sterically stabilized with polyvinyl acetate (PVA).These were characterized for particle size, ζ potential, polydispersity index, scanning electron microscopy (SEM), differential scanning calorimetry (DSC), X-ray diffraction (XRD) pattern and release behavior. The effect of nanoprecipitation on oral bioavailability of furosemide nanosuspension was studied by in vitro dissolution and in vivo absorption study in rats and compared to pure drug. The stable nanosuspension was obtained with average size range of the precipitated nanoparticles between 150-300 nm and was found to be homogenous showing a narrow polydispersity index of 0.3±0.1. DSC and XRD studies indicated that the crystalline furosemide drug was converted to amorphous form upon precipitation into nanoparticles. The release profiles of nanosuspension formulation showed up to 81.2% release in 4 h. The in vivo studies on rats revealed a significant increase in the oral absorption of furosemide in the nanosuspension compared to pure drug. The AUC0→24 and Cmax values of nanosuspension were approximately 1.38 and 1.68-fold greater than that of pure drug, respectively. Furosemide nanosuspension showed 20.06±0.02 % decrease in systolic blood pressure compared to 13.37±0.02 % in plain furosemide suspension, respectively. The improved oral bioavailability and pharmacodynamics effect of furosemide may be due to the improved dissolution of furosemide in simulated gastric fluid which results in enhanced oral systemic absorption of furosemide from stomach region where it has better permeability. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=furosemide" title="furosemide">furosemide</a>, <a href="https://publications.waset.org/abstracts/search?q=nanosuspension" title=" nanosuspension"> nanosuspension</a>, <a href="https://publications.waset.org/abstracts/search?q=bioavailability%20enhancement" title=" bioavailability enhancement"> bioavailability enhancement</a>, <a href="https://publications.waset.org/abstracts/search?q=nanoprecipitation" title=" nanoprecipitation"> nanoprecipitation</a>, <a href="https://publications.waset.org/abstracts/search?q=oral%20drug%20delivery" title=" oral drug delivery "> oral drug delivery </a> </p> <a href="https://publications.waset.org/abstracts/10344/nanoprecipitation-with-ultrasonication-for-enhancement-of-oral-bioavailability-of-fursemide-pharmacokinetics-and-pharmacodynamics-study-in-rat-model" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/10344.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">573</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> Controlled Drug Delivery System for Delivery of Poor Water Soluble Drugs</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Raj%20Kumar">Raj Kumar</a>, <a href="https://publications.waset.org/abstracts/search?q=Prem%20Felix%20Siril"> Prem Felix Siril</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The poor aqueous solubility of many pharmaceutical drugs and potential drug candidates is a big challenge in drug development. Nanoformulation of such candidates is one of the major solutions for the delivery of such drugs. We initially developed the evaporation assisted solvent-antisolvent interaction (EASAI) method. EASAI method is use full to prepared nanoparticles of poor water soluble drugs with spherical morphology and particles size below 100 nm. However, to further improve the effect formulation to reduce number of dose and side effect it is important to control the delivery of drugs. However, many drug delivery systems are available. Among the many nano-drug carrier systems, solid lipid nanoparticles (SLNs) have many advantages over the others such as high biocompatibility, stability, non-toxicity and ability to achieve controlled release of drugs and drug targeting. SLNs can be administered through all existing routes due to high biocompatibility of lipids. SLNs are usually composed of lipid, surfactant and drug were encapsulated in lipid matrix. A number of non-steroidal anti-inflammatory drugs (NSAIDs) have poor bioavailability resulting from their poor aqueous solubility. In the present work, SLNs loaded with NSAIDs such as Nabumetone (NBT), Ketoprofen (KP) and Ibuprofen (IBP) were successfully prepared using different lipids and surfactants. We studied and optimized experimental parameters using a number of lipids, surfactants and NSAIDs. The effect of different experimental parameters such as lipid to surfactant ratio, volume of water, temperature, drug concentration and sonication time on the particles size of SLNs during the preparation using hot-melt sonication was studied. It was found that particles size was directly proportional to drug concentration and inversely proportional to surfactant concentration, volume of water added and temperature of water. SLNs prepared at optimized condition were characterized thoroughly by using different techniques such as dynamic light scattering (DLS), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), atomic force microscopy (AFM), X-ray diffraction (XRD) and differential scanning calorimetry and Fourier transform infrared spectroscopy (FTIR). We successfully prepared the SLN of below 220 nm using different lipids and surfactants combination. The drugs KP, NBT and IBP showed 74%, 69% and 53% percentage of entrapment efficiency with drug loading of 2%, 7% and 6% respectively in SLNs of Campul GMS 50K and Gelucire 50/13. In-vitro drug release profile of drug loaded SLNs is shown that nearly 100% of drug was release in 6 h. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=nanoparticles" title="nanoparticles">nanoparticles</a>, <a href="https://publications.waset.org/abstracts/search?q=delivery" title=" delivery"> delivery</a>, <a href="https://publications.waset.org/abstracts/search?q=solid%20lipid%20nanoparticles" title=" solid lipid nanoparticles"> solid lipid nanoparticles</a>, <a href="https://publications.waset.org/abstracts/search?q=hot-melt%20sonication" title=" hot-melt sonication"> hot-melt sonication</a>, <a href="https://publications.waset.org/abstracts/search?q=poor%20water%20soluble%20drugs" title=" poor water soluble drugs"> poor water soluble drugs</a>, <a href="https://publications.waset.org/abstracts/search?q=solubility" title=" solubility"> solubility</a>, <a href="https://publications.waset.org/abstracts/search?q=bioavailability" title=" bioavailability"> bioavailability</a> </p> <a href="https://publications.waset.org/abstracts/46151/controlled-drug-delivery-system-for-delivery-of-poor-water-soluble-drugs" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/46151.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">312</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Use of Low-Cost Hydrated Hydrogen Sulphate-Based Protic Ionic Liquids for Extraction of Cellulose-Rich Materials from Common Wheat (Triticum Aestivum) Straw</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Chris%20Miskelly">Chris Miskelly</a>, <a href="https://publications.waset.org/abstracts/search?q=Eoin%20Cunningham"> Eoin Cunningham</a>, <a href="https://publications.waset.org/abstracts/search?q=Beatrice%20Smyth"> Beatrice Smyth</a>, <a href="https://publications.waset.org/abstracts/search?q=John.%20D.%20Holbrey"> John. D. Holbrey</a>, <a href="https://publications.waset.org/abstracts/search?q=Gosia%20Swadzba-Kwasny"> Gosia Swadzba-Kwasny</a>, <a href="https://publications.waset.org/abstracts/search?q=Emily%20L.%20Byrne"> Emily L. Byrne</a>, <a href="https://publications.waset.org/abstracts/search?q=Yoan%20Delavoux"> Yoan Delavoux</a>, <a href="https://publications.waset.org/abstracts/search?q=Mantian%20Li."> Mantian Li.</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Recently, the use of ionic liquids (ILs) for the preparation of lignocellulose derived cellulosic materials as alternatives to petrochemical feedstocks has been the focus of considerable research interest. While the technical viability of IL-based lignocellulose treatment methodologies has been well established, the high cost of reagents inhibits commercial feasibility. This work aimed to assess the technoeconomic viability of the preparation of cellulose rich materials (CRMs) using protic ionic liquids (PILs) synthesized from low cost alkylamines and sulphuric acid. For this purpose, the tertiary alkylamines, triethylamine, and dimethylbutylamine were selected. Bulk scale production cost of the synthesized PILs, triethylammonium hydrogen sulphate and dimetheylbutylammonium hydrogen sulphate, was reported as $0.78 kg-1 to $1.24 kg-1. CRMs were prepared through the treatment of common wheat (Triticum aestivum) straw with these PILs. By controlling treatment parameters, CRMs with a cellulose content of ≥ 80 wt% were prepared. This was achieved using a T. aestivum straw to PIL loading ratio of 1:15 w/w, a treatment duration of 180 minutes, and ethanol as a cellulose antisolvent. Infrared spectra data and decreased onset degradation temperature of CRMs (ΔTONSET ~ 70 °C) suggested the formation of cellulose sulphate esters during treatment. Chemical derivatisation can aid the dispersion of prepared CRMs in non-polar polymer/ composite matrices, but act as a barrier to thermal processing at temperatures above 150 °C. It was also shown that treatment increased the crystallinity of CRMs (ΔCrI ~ 40 %) without altering the native crystalline structure or crystallite size (~ 2.6 nm) of cellulose; peaks associated with the cellulose I crystalline planes (110), (200), and (004) were observed at Bragg angles 16.0 °, 22.5 ° and 35.0 ° respectively. This highlighted the inability of assessed PILs to dissolve crystalline cellulose and was attributed to the high acidity (pKa ~ - 1.92 to - 6.42) of sulphuric acid derived anions. Electron micrographs revealed that the stratified multilayer tissue structure of untreated T. aestivum straw was significantly modified during treatment. T. aestivum straw particles were disassembled during treatment, with prepared CRMs adopting a golden-brown film-like appearance. This work demonstrated the degradation of non-cellulosic fractions of lignocellulose without dissolution of cellulose. It is the first to report on the derivatisation of cellulose during treatment with protic hydrogen sulphate ionic liquids, and the potential implications of this with reference to biopolymer feedstock preparation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cellulose" title="cellulose">cellulose</a>, <a href="https://publications.waset.org/abstracts/search?q=extraction" title=" extraction"> extraction</a>, <a href="https://publications.waset.org/abstracts/search?q=protic%20ionic%20liquids" title=" protic ionic liquids"> protic ionic liquids</a>, <a href="https://publications.waset.org/abstracts/search?q=esterification" title=" esterification"> esterification</a>, <a href="https://publications.waset.org/abstracts/search?q=thermal%20stability" title=" thermal stability"> thermal stability</a>, <a href="https://publications.waset.org/abstracts/search?q=waste%20valorisation" title=" waste valorisation"> waste valorisation</a>, <a href="https://publications.waset.org/abstracts/search?q=biopolymer%20feedstock" title=" biopolymer feedstock"> biopolymer feedstock</a> </p> <a href="https://publications.waset.org/abstracts/188889/use-of-low-cost-hydrated-hydrogen-sulphate-based-protic-ionic-liquids-for-extraction-of-cellulose-rich-materials-from-common-wheat-triticum-aestivum-straw" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/188889.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">36</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a 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