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id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Vai a una voce in un'altra lingua. Disponibile in 24 lingue" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-24" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">24 lingue</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D8%A5%D9%86%D8%AA%D8%B1%D9%84%D9%88%D9%83%D9%8A%D9%86-10" title="إنترلوكين-10 - arabo" lang="ar" hreflang="ar" data-title="إنترلوكين-10" data-language-autonym="العربية" data-language-local-name="arabo" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-cs mw-list-item"><a href="https://cs.wikipedia.org/wiki/Interleukin_10" title="Interleukin 10 - ceco" lang="cs" hreflang="cs" data-title="Interleukin 10" data-language-autonym="Čeština" data-language-local-name="ceco" class="interlanguage-link-target"><span>Čeština</span></a></li><li class="interlanguage-link interwiki-cy mw-list-item"><a href="https://cy.wikipedia.org/wiki/IL10" title="IL10 - gallese" lang="cy" hreflang="cy" data-title="IL10" data-language-autonym="Cymraeg" data-language-local-name="gallese" class="interlanguage-link-target"><span>Cymraeg</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Interleukin-10" title="Interleukin-10 - tedesco" lang="de" hreflang="de" data-title="Interleukin-10" data-language-autonym="Deutsch" data-language-local-name="tedesco" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Interleukin_10" title="Interleukin 10 - inglese" lang="en" hreflang="en" data-title="Interleukin 10" data-language-autonym="English" data-language-local-name="inglese" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Interleucina_-_10" title="Interleucina - 10 - spagnolo" lang="es" hreflang="es" data-title="Interleucina - 10" data-language-autonym="Español" data-language-local-name="spagnolo" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-et mw-list-item"><a href="https://et.wikipedia.org/wiki/Interleukiin-10" title="Interleukiin-10 - estone" lang="et" hreflang="et" data-title="Interleukiin-10" data-language-autonym="Eesti" data-language-local-name="estone" class="interlanguage-link-target"><span>Eesti</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D8%A7%DB%8C%D9%86%D8%AA%D8%B1%D9%84%D9%88%DA%A9%DB%8C%D9%86_%DB%B1%DB%B0" title="اینترلوکین ۱۰ - persiano" lang="fa" hreflang="fa" data-title="اینترلوکین ۱۰" data-language-autonym="فارسی" data-language-local-name="persiano" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Interleukine_10" title="Interleukine 10 - francese" lang="fr" hreflang="fr" data-title="Interleukine 10" data-language-autonym="Français" data-language-local-name="francese" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/Interleucina-10" title="Interleucina-10 - galiziano" lang="gl" hreflang="gl" data-title="Interleucina-10" data-language-autonym="Galego" data-language-local-name="galiziano" class="interlanguage-link-target"><span>Galego</span></a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/%D7%90%D7%99%D7%A0%D7%98%D7%A8%D7%9C%D7%95%D7%A7%D7%99%D7%9F_10" title="אינטרלוקין 10 - ebraico" lang="he" hreflang="he" data-title="אינטרלוקין 10" data-language-autonym="עברית" data-language-local-name="ebraico" class="interlanguage-link-target"><span>עברית</span></a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Interleukin-10" title="Interleukin-10 - indonesiano" lang="id" hreflang="id" data-title="Interleukin-10" data-language-autonym="Bahasa Indonesia" data-language-local-name="indonesiano" class="interlanguage-link-target"><span>Bahasa Indonesia</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%82%A4%E3%83%B3%E3%82%BF%E3%83%BC%E3%83%AD%E3%82%A4%E3%82%AD%E3%83%B3-10" title="インターロイキン-10 - giapponese" lang="ja" hreflang="ja" data-title="インターロイキン-10" data-language-autonym="日本語" data-language-local-name="giapponese" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-lv mw-list-item"><a href="https://lv.wikipedia.org/wiki/Interleik%C4%ABns_10" title="Interleikīns 10 - lettone" lang="lv" hreflang="lv" data-title="Interleikīns 10" data-language-autonym="Latviešu" data-language-local-name="lettone" class="interlanguage-link-target"><span>Latviešu</span></a></li><li class="interlanguage-link interwiki-ms mw-list-item"><a href="https://ms.wikipedia.org/wiki/Interleukin_10" title="Interleukin 10 - malese" lang="ms" hreflang="ms" data-title="Interleukin 10" data-language-autonym="Bahasa Melayu" data-language-local-name="malese" class="interlanguage-link-target"><span>Bahasa Melayu</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Interleukine-10" title="Interleukine-10 - olandese" lang="nl" hreflang="nl" data-title="Interleukine-10" data-language-autonym="Nederlands" data-language-local-name="olandese" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Interleukina_10" title="Interleukina 10 - polacco" lang="pl" hreflang="pl" data-title="Interleukina 10" data-language-autonym="Polski" data-language-local-name="polacco" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Interleucina_10" title="Interleucina 10 - portoghese" lang="pt" hreflang="pt" data-title="Interleucina 10" data-language-autonym="Português" data-language-local-name="portoghese" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%98%D0%BD%D1%82%D0%B5%D1%80%D0%BB%D0%B5%D0%B9%D0%BA%D0%B8%D0%BD_10" title="Интерлейкин 10 - russo" lang="ru" hreflang="ru" data-title="Интерлейкин 10" data-language-autonym="Русский" data-language-local-name="russo" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Interleukin_10" title="Interleukin 10 - serbo-croato" lang="sh" hreflang="sh" data-title="Interleukin 10" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="serbo-croato" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/%D0%98%D0%BD%D1%82%D0%B5%D1%80%D0%BB%D0%B5%D1%83%D0%BA%D0%B8%D0%BD_10" title="Интерлеукин 10 - serbo" lang="sr" hreflang="sr" data-title="Интерлеукин 10" data-language-autonym="Српски / srpski" data-language-local-name="serbo" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/%C4%B0nterl%C3%B6kin_10" title="İnterlökin 10 - turco" lang="tr" hreflang="tr" data-title="İnterlökin 10" data-language-autonym="Türkçe" data-language-local-name="turco" class="interlanguage-link-target"><span>Türkçe</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/IL10" title="IL10 - ucraino" lang="uk" hreflang="uk" data-title="IL10" data-language-autonym="Українська" data-language-local-name="ucraino" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E7%99%BD%E7%BB%86%E8%83%9E%E4%BB%8B%E7%B4%A0-10" title="白细胞介素-10 - cinese" lang="zh" hreflang="zh" data-title="白细胞介素-10" data-language-autonym="中文" data-language-local-name="cinese" class="interlanguage-link-target"><span>中文</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span 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I contenuti hanno solo fine illustrativo e non sostituiscono il parere medico: <a href="/wiki/Wikipedia:Disclaimer_medico" title="Wikipedia:Disclaimer medico">leggi le avvertenze</a>.</span></div> </div> <style data-mw-deduplicate="TemplateStyles:r133964453">.mw-parser-output .avviso .mbox-text-div>div,.mw-parser-output .avviso .mbox-text-full-div>div{font-size:90%}.mw-parser-output .avviso .mbox-image{flex-basis:52px;flex-grow:0;flex-shrink:0}.mw-parser-output .avviso .mbox-text-full-div .hide-when-compact{display:block}</style><div style="" class="ambox metadata noprint plainlinks avviso avviso-generico"> <div class="avviso-immagine mbox-image noprint"><span typeof="mw:File"><a href="/wiki/File:Antibody_with_CDRs.svg" class="mw-file-description" title="Abbozzo immunologia"><img alt="Abbozzo immunologia" src="//upload.wikimedia.org/wikipedia/commons/thumb/7/79/Antibody_with_CDRs.svg/45px-Antibody_with_CDRs.svg.png" decoding="async" width="45" height="45" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/79/Antibody_with_CDRs.svg/68px-Antibody_with_CDRs.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/79/Antibody_with_CDRs.svg/90px-Antibody_with_CDRs.svg.png 2x" data-file-width="115" data-file-height="115" /></a></span></div> <div class="avviso-testo mbox-text"> <div class="mbox-text-div"><b>Questa voce  sull'argomento immunologia è solo un <a href="/wiki/Aiuto:Abbozzo" title="Aiuto:Abbozzo">abbozzo</a></b>.<br /> <div style="font-size:90%;"><a class="external text" href="https://it.wikipedia.org/w/index.php?title=Interleuchina_10&action=edit">Contribuisci</a> a migliorarla secondo le <a href="/wiki/Aiuto:Manuale_di_stile" title="Aiuto:Manuale di stile">convenzioni di Wikipedia</a>. </div> <div class="hide-when-compact"> </div> </div> </div> </div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r133964453"><div style="" class="ambox metadata plainlinks avviso avviso-contenuto"> <div class="avviso-immagine mbox-image noprint"><span typeof="mw:File"><a href="/wiki/File:Question_book-4.svg" class="mw-file-description" title="Niente fonti!"><img alt="Niente fonti!" src="//upload.wikimedia.org/wikipedia/commons/thumb/6/64/Question_book-4.svg/45px-Question_book-4.svg.png" decoding="async" width="45" height="35" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/64/Question_book-4.svg/68px-Question_book-4.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/64/Question_book-4.svg/90px-Question_book-4.svg.png 2x" data-file-width="262" data-file-height="204" /></a></span></div> <div class="avviso-testo mbox-text"> <div class="mbox-text-div"><b>Questa voce o sezione  sull'argomento immunologia <a href="/wiki/Wikipedia:Uso_delle_fonti" title="Wikipedia:Uso delle fonti">non cita le fonti necessarie</a> o quelle presenti sono insufficienti</b>. <div class="hide-when-compact"> <div class="noprint"><hr />Puoi <a class="external text" href="https://it.wikipedia.org/w/index.php?title=Interleuchina_10&action=edit">migliorare questa voce</a> aggiungendo citazioni da <a href="/wiki/Wikipedia:Fonti_attendibili" title="Wikipedia:Fonti attendibili">fonti attendibili</a> secondo le <a href="/wiki/Wikipedia:Uso_delle_fonti" title="Wikipedia:Uso delle fonti">linee guida sull'uso delle fonti</a>. </div> </div> </div> </div> </div> <table class="infobox sinottico" summary="Tabella sinottica che riassume i principali dati del soggetto"><tbody><tr class="sinottico_testata"><th colspan="2" style="background:#C2C3FF; color:#000;">Interleuchina 10</th></tr><tr><td class="sinottico_testo_centrale" colspan="2"><figure class="mw-halign-center" typeof="mw:File/Frameless"><a href="/wiki/File:IL10_Crystal_Structure.rsh.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/3/38/IL10_Crystal_Structure.rsh.png/260px-IL10_Crystal_Structure.rsh.png" decoding="async" width="260" height="192" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/38/IL10_Crystal_Structure.rsh.png/390px-IL10_Crystal_Structure.rsh.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/38/IL10_Crystal_Structure.rsh.png/520px-IL10_Crystal_Structure.rsh.png 2x" data-file-width="1018" data-file-height="753" /></a><figcaption></figcaption></figure>Struttura terziaria dell'IL-10</td></tr><tr class="sinottico_divisione"><th colspan="2" style="background:#E2F3EF; color:#000;"><a href="/wiki/Gene" title="Gene">Gene</a></th></tr><tr><th><i><a href="/wiki/HUGO" class="mw-redirect" title="HUGO">HUGO</a></i></th><td><a rel="nofollow" class="external text" href="http://www.genenames.org/cgi-bin/search?search_type=all&search=IL10&submit=Submit">IL10</a> CSIF; IL-10; IL10A; MGC126450; MGC126451; TGIF </td></tr><tr><th><a href="/wiki/Locus_genico" title="Locus genico">Locus</a></th><td><a href="/wiki/Cromosoma_1" title="Cromosoma 1">Chr. 1</a> <i><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/Omim/getmap.cgi?chromosome=1q32.1">q32.1</a></i> </td></tr><tr class="sinottico_divisione"><th colspan="2" style="background:#E2F3EF; color:#000;"><a href="/wiki/Proteina" class="mw-redirect" title="Proteina">Proteina</a></th></tr><tr><th><i><a href="/wiki/UniProt" title="UniProt">UniProt</a></i></th><td><a rel="nofollow" class="external text" href="http://www.uniprot.org/uniprot/P22301">P22301</a> </td></tr><tr><td class="sinottico_piede2 noprint nomobile metadata" colspan="2"><a href="https://www.wikidata.org/wiki/Q423698" class="extiw" title="d:Q423698"><span title="Modifica i dati della voce Interleuchina 10 su Wikidata">Modifica dati su Wikidata</span></a><b> ·</b> <a href="/wiki/Template:Proteina/man" title="Template:Proteina/man"><span title="Manuale del template Proteina">Manuale</span></a></td></tr></tbody></table> <p>L'<b>interleuchina 10</b> è una <a href="/wiki/Citochina" title="Citochina">citochina</a> anti-<a href="/wiki/Infiammazione" title="Infiammazione">infiammatoria</a>. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Struttura">Struttura</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleuchina_10&veaction=edit&section=1" title="Modifica la sezione Struttura" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Interleuchina_10&action=edit&section=1" title="Edit section's source code: Struttura"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>IL-10 è un dimero con 6 domini ad <a href="/wiki/Alfa_elica" title="Alfa elica">α-elica</a> presenti su ciascun monomero che si legano non covalentemente con l'altro monomero. Il suo recettore, IL-10R fa parte dei recettori per citochine di tipo II e sul versante citoplasmatico è associato a Jak1 e a Tyk2 che trasducono il segnale mediante STAT3. IL-10 è prodotta principalmente dai <a href="/wiki/Monocita" title="Monocita">monociti</a>, dai <a href="/wiki/Linfocita" title="Linfocita">linfociti</a> T regolatori e dai linfociti T<sub>H</sub>2. </p> <div class="mw-heading mw-heading2"><h2 id="Funzione">Funzione</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleuchina_10&veaction=edit&section=2" title="Modifica la sezione Funzione" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Interleuchina_10&action=edit&section=2" title="Edit section's source code: Funzione"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>È in grado di inibire la sintesi di citochine pro-infiammatorie quali <a href="/wiki/Interferone" class="mw-redirect" title="Interferone">IFN-γ</a>, <a href="/wiki/Interleuchina_2" title="Interleuchina 2">IL-2</a>, IL-3, <a href="/wiki/Fattore_di_necrosi_tumorale" title="Fattore di necrosi tumorale">TNF-α</a> e GM-CSF, prodotte da cellule quali macrofagi e <a href="/wiki/Linfociti_T" class="mw-redirect" title="Linfociti T">linfociti T</a> helper di classe 1. I macrofagi che la producono vengono inattivati tramite un feedback negativo, stimola invece la proliferazione dei linfociti B e la produzione di anticorpi a carico delle plasmacellule. Inoltre, ha mostrato anche un ruolo importante nella soppressione della capacità di presentazione dell'antigene da parte delle <a href="/wiki/Cellula_APC" class="mw-redirect" title="Cellula APC">cellule APC</a>, questo a causa di un effetto depressivo nella produzione di molecole <a href="/w/index.php?title=MHC_II&action=edit&redlink=1" class="new" title="MHC II (la pagina non esiste)">MHC II</a>. </p><p>Proprio per il legame con IFN-y e TNF ha una componente di stimolo enzimatico con gli epatociti. </p> <div class="mw-heading mw-heading2"><h2 id="Voci_correlate">Voci correlate</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleuchina_10&veaction=edit&section=3" title="Modifica la sezione Voci correlate" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Interleuchina_10&action=edit&section=3" title="Edit section's source code: Voci correlate"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Cellula_APC" class="mw-redirect" title="Cellula APC">Cellula APC</a></li> <li><a href="/wiki/Citochina" title="Citochina">Citochina</a></li> <li><a href="/wiki/Immunit%C3%A0_innata" class="mw-redirect" title="Immunità innata">Immunità innata</a></li> <li><a href="/wiki/Interleuchina" class="mw-redirect" title="Interleuchina">Interleuchina</a></li> <li><a href="/wiki/Linfocita" title="Linfocita">Linfocita</a></li> <li><a href="/wiki/Linfocita_T" title="Linfocita T">Linfocita T</a></li> <li><a href="/wiki/Monocita" title="Monocita">Monocita</a></li> <li><a href="/wiki/Sistema_immunitario" title="Sistema immunitario">Sistema immunitario</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="Altri_progetti">Altri progetti</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleuchina_10&veaction=edit&section=4" title="Modifica la sezione Altri progetti" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Interleuchina_10&action=edit&section=4" title="Edit section's source code: Altri progetti"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <div id="interProject" class="toccolours" style="display: none; clear: both; margin-top: 2em"><p id="sisterProjects" style="background-color: #efefef; color: black; font-weight: bold; margin: 0"><span>Altri progetti</span></p><ul title="Collegamenti verso gli altri progetti Wikimedia"> <li class="" title=""><span class="plainlinks" title="commons:Category:Interferons or interleukin-10 (IL-10)"><a class="external text" href="https://commons.wikimedia.org/wiki/Category:Interferons_or_interleukin-10_(IL-10)?uselang=it">Wikimedia Commons</a></span></li></ul></div> <ul><li><span typeof="mw:File"><a href="https://commons.wikimedia.org/wiki/?uselang=it" title="Collabora a Wikimedia Commons"><img alt="Collabora a Wikimedia Commons" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/4a/Commons-logo.svg/18px-Commons-logo.svg.png" decoding="async" width="18" height="24" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/4a/Commons-logo.svg/27px-Commons-logo.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/4a/Commons-logo.svg/36px-Commons-logo.svg.png 2x" data-file-width="1024" data-file-height="1376" /></a></span> <span class="plainlinks"><a class="external text" href="https://commons.wikimedia.org/wiki/?uselang=it">Wikimedia Commons</a></span> contiene immagini o altri file su <b><span class="plainlinks"><a class="external text" href="https://commons.wikimedia.org/wiki/Category:Interferons_or_interleukin-10_(IL-10)?uselang=it">Interleuchina 10</a></span></b></li></ul> <style data-mw-deduplicate="TemplateStyles:r141815314">.mw-parser-output .navbox{border:1px solid #aaa;clear:both;margin:auto;padding:2px;width:100%}.mw-parser-output .navbox th{padding-left:1em;padding-right:1em;text-align:center}.mw-parser-output .navbox>tbody>tr:first-child>th{background:#ccf;font-size:90%;width:100%;color:var(--color-base,black)}.mw-parser-output .navbox_navbar{float:left;margin:0;padding:0 10px 0 0;text-align:left;width:6em}.mw-parser-output .navbox_title{font-size:110%}.mw-parser-output .navbox_abovebelow{background:#ddf;font-size:90%;font-weight:normal}.mw-parser-output .navbox_group{background:#ddf;font-size:90%;padding:0 10px;white-space:nowrap}.mw-parser-output .navbox_list{font-size:90%;width:100%}.mw-parser-output .navbox_list a{white-space:nowrap}html:not(.vector-feature-night-mode-enabled) .mw-parser-output .navbox_odd{background:#fdfdfd;color:var(--color-base,black)}html:not(.vector-feature-night-mode-enabled) .mw-parser-output .navbox_even{background:#f7f7f7;color:var(--color-base,black)}.mw-parser-output .navbox a.mw-selflink{color:var(--color-base,black)}.mw-parser-output .navbox_center{text-align:center}.mw-parser-output .navbox .navbox_image{padding-left:7px;vertical-align:middle;width:0}.mw-parser-output .navbox+.navbox{margin-top:-1px}.mw-parser-output .navbox .mw-collapsible-toggle{font-weight:normal;text-align:right;width:7em}body.skin--responsive .mw-parser-output .navbox_image img{max-width:none!important}.mw-parser-output .subnavbox{margin:-3px;width:100%}.mw-parser-output .subnavbox_group{background:#e6e6ff;padding:0 10px}@media screen{html.skin-theme-clientpref-night .mw-parser-output .navbox>tbody>tr:first-child>th{background:var(--background-color-interactive)!important}html.skin-theme-clientpref-night .mw-parser-output .navbox th{color:var(--color-base)!important}html.skin-theme-clientpref-night .mw-parser-output .navbox_abovebelow,html.skin-theme-clientpref-night .mw-parser-output .navbox_group{background:var(--background-color-interactive-subtle)!important}html.skin-theme-clientpref-night .mw-parser-output .subnavbox_group{background:var(--background-color-neutral-subtle)!important}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .navbox>tbody>tr:first-child>th{background:var(--background-color-interactive)!important}html.skin-theme-clientpref-os .mw-parser-output .navbox th{color:var(--color-base)!important}html.skin-theme-clientpref-os .mw-parser-output .navbox_abovebelow,html.skin-theme-clientpref-os .mw-parser-output .navbox_group{background:var(--background-color-interactive-subtle)!important}html.skin-theme-clientpref-os .mw-parser-output .subnavbox_group{background:var(--background-color-neutral-subtle)!important}}</style><table class="navbox mw-collapsible mw-collapsed noprint metadata" id="navbox-Sistema_immunitario"><tbody><tr><th colspan="2"><div class="navbox_navbar"><div class="noprint plainlinks" style="background-color:transparent; padding:0; font-size:xx-small; color:var(--color-base, #000000); white-space:nowrap;"><a href="/wiki/Template:Sistema_immunitario" title="Template:Sistema immunitario"><span title="Vai alla pagina del template">V</span></a> · <a href="/wiki/Discussioni_template:Sistema_immunitario" title="Discussioni template:Sistema immunitario"><span title="Discuti del template">D</span></a> · <a class="external text" href="https://it.wikipedia.org/w/index.php?title=Template:Sistema_immunitario&action=edit"><span title="Modifica il template. Usa l'anteprima prima di salvare">M</span></a></div></div><span class="navbox_title"><a href="/wiki/Sistema_immunitario" title="Sistema immunitario">Sistema immunitario</a></span></th></tr><tr><th colspan="1" class="navbox_group" style="text-align:right;"><a href="/wiki/Sistema_immunitario_innato" title="Sistema immunitario innato">Immunità innata</a></th><td colspan="1" class="navbox_list navbox_odd" style="text-align:left;"><table class="subnavbox"><tbody><tr><th class="subnavbox_group">Cellule</th><td colspan="1"><a href="/wiki/Granulociti" class="mw-redirect" title="Granulociti">Granulociti</a> (<i><a href="/wiki/Neutrofili" class="mw-redirect" title="Neutrofili">Neutrofili</a> · <a href="/wiki/Eosinofili" class="mw-redirect" title="Eosinofili">Eosinofili</a> · <a href="/wiki/Basofili" class="mw-redirect" title="Basofili">Basofili</a></i>) · <a href="/wiki/Macrofagi" class="mw-redirect" title="Macrofagi">Macrofagi</a> (<i><a href="/wiki/Cellule_di_Kupffer" class="mw-redirect" title="Cellule di Kupffer">cellule di Kupffer</a> · <a href="/wiki/Microglia" title="Microglia">microglia</a></i>) · <a href="/wiki/Cellule_dendritiche" class="mw-redirect" title="Cellule dendritiche">Cellule dendritiche</a> (<i><a href="/wiki/Cellula_di_Langerhans" title="Cellula di Langerhans">cellule di Langerhans</a></i>) · <a href="/wiki/Mastociti" class="mw-redirect" title="Mastociti">Mastociti</a> · <a href="/wiki/Linfociti_NK" class="mw-redirect" title="Linfociti NK">Linfociti NK</a></td></tr><tr><th class="subnavbox_group">Meccanismi</th><td colspan="1"><a href="/wiki/Infiammazione" title="Infiammazione">Infiammazione</a> (<i><a href="/wiki/Toll-like_receptor" title="Toll-like receptor">Toll-like receptor</a> · <a href="/wiki/Citochina" title="Citochina">Citochine</a> · <a href="/wiki/Chemochine" title="Chemochine">Chemochine</a></i>) · <a href="/wiki/Sistema_del_complemento" title="Sistema del complemento">Sistema del complemento</a> · <a 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