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The subgroup exists across multiple diseases and patients within it demonstrate poor prognosis across multiple cancers, including breast, lung, colon, renal, pancreatic, stomach, bladder, ovarian, melanoma and glioblastoma.</p> <p>A 15 gene signature has been developed to prospectively identify patients which fall into the EMT molecular subgroup from formalin-fixed paraffin-embedded (FFPE) tissue and can be used to select patients for:</p> <ol> <li>MAPK targeted therapies (for example: MEK, p38 inhibitors)</li> <li>EMT targeted therapies (for example: AXL inhibitors)</li> <li>RTK targeted therapies (for example: Tyrosine kinase inhibitors)</li> </ol> <div class="u-flex u-flex-justify-start u-m-t-auto "> <a class="c-btn c-btn-secondary c-btn--red" href="/diagnostics/contact-us/">Contact Us</a> </div> <div class="u-flex u-block@m"> </div> <p> </p> <div class="u-flex u-block@m"> <div class="u-align-center u-p-a2 u-bg-light-grey u-m-r1 u-m-b1" style="max-width: 400px;"> <p><a href="/diagnostics/claratreport/"><img decoding="async" class="aligncenter wp-image-51373 lazyload" data-src="/diagnostics/wp-content/uploads/sites/3/2020/03/claraT-logo-1-1.png" alt="" width="154" height="108" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" style="--smush-placeholder-width: 154px; --smush-placeholder-aspect-ratio: 154/108;"><noscript><img decoding="async" class="aligncenter wp-image-51373 " src="/diagnostics/wp-content/uploads/sites/3/2020/03/claraT-logo-1-1.png" alt="" width="154" height="108"></noscript></a></p> <h4><a href="/diagnostics/claratreport/">Almac EMT Assay</a></h4> </div> <div class="u-align-center u-p-a2 u-bg-light-grey u-m-r1 u-m-b1" style="max-width: 400px;"> <p><br> <img fetchpriority="high" decoding="async" class="aligncenter wp-image-51374 " src="/diagnostics/wp-content/uploads/sites/3/2020/03/Untitled-2-1.png" alt="" width="394" height="166"></p> </div> </div> <div class="u-align-center u-p-a2 u-bg-light-grey u-m-r1 u-m-b1" style="max-width: 625px;"> <p>Assessment of the Almac EMT Assay can be made through use of Almac Diagnostic Services unique gene expression report, <a href="/diagnostics/claratreport/">clara<sup>T</sup></a>.This provides visualisation of the EMT Assay scores as an easy-to-interpret graduated bar.</p> </div> <div style="height:56px" aria-hidden="true" class="wp-block-spacer"></div> <div class="o-wrapper"> <div class="o-grid"> <div class="o-grid__item u-width-full "> <h2 class="u-m-b4">Related Resources</h2> </div> </div> <div class="o-grid u-flex-align-stretch u-m-b3"> <article class="o-grid__item u-width-4/12 u-width-4/12@l u-width-6/12@m u-width-full@s u-flex u-m-b3 u-a-full"> <div class="c-related-resources__panel u-flex u-flex-direction-column u-flex-align-flex-start u-p-x4 u-p-y3 u-m-b2"> <p class="c-resource__category">Poster</p> <h4 class="u-m-t2">Development of a Pan-Cancer 15 Gene Expression Signature to Detect a Subgroup Driven by MAPK Signalling</h4> <a 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