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Identification of Matrix Metalloproteinase 11 as a Prognostic Biomarker in Pancreatic Cancer | Anticancer Research
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Delinasios), All rights reserved" /> <meta name="DC.AccessRights" content="restricted" /> <meta name="DC.Description" content="Background/Aim: The aim of this study was to investigate matrix metalloproteinase 11 (MMP11) as a promising biomarker in human pancreatic cancer. Materials and Methods: A consecutive eliminating method was used to select biomarker candidates in pancreatic cancer. mRNA and protein expression levels of candidates were determined in tissues and whole blood samples of healthy donors and pancreatic cancer patients. The prognostic value of MMP11 was determined using various data-sets and Liptak's Z analysis. Results: Analysis using Gene Expression Omnibus (GEO) database showed significantly higher MMP11 mRNA expression in pancreatic cancer tissues compared to that in various normal tissues. MMP11 protein was specifically expressed in pancreatic cancer tissues, but not in various normal or other cancer tissues. Secreted MMP11 levels could be measured using easily accessible techniques and whole blood samples of pancreatic cancer. In addition, high levels of MMP11 were associated with poor prognosis of pancreatic cancer patients. Conclusion: MMP11 may be a promising prognostic biomarker for pancreatic cancer patients." /> <meta name="DC.Contributor" content="JUNGWHOI LEE" /> <meta name="DC.Contributor" content="JUNGSUL LEE" /> <meta name="DC.Contributor" content="JAE HOON KIM" /> <meta name="article:published_time" content="2019-11-01" /> <meta name="article:section" content="Experimental Studies" /> <meta name="citation_title" content="Identification of Matrix Metalloproteinase 11 as a Prognostic Biomarker in Pancreatic Cancer" /> <meta name="citation_abstract" lang="en" content="<p>Background/Aim: The aim of this study was to investigate matrix metalloproteinase 11 (MMP11) as a promising biomarker in human pancreatic cancer. Materials and Methods: A consecutive eliminating method was used to select biomarker candidates in pancreatic cancer. mRNA and protein expression levels of candidates were determined in tissues and whole blood samples of healthy donors and pancreatic cancer patients. The prognostic value of MMP11 was determined using various data-sets and Liptak9s Z analysis. Results: Analysis using Gene Expression Omnibus (GEO) database showed significantly higher MMP11 mRNA expression in pancreatic cancer tissues compared to that in various normal tissues. MMP11 protein was specifically expressed in pancreatic cancer tissues, but not in various normal or other cancer tissues. Secreted MMP11 levels could be measured using easily accessible techniques and whole blood samples of pancreatic cancer. In addition, high levels of MMP11 were associated with poor prognosis of pancreatic cancer patients. Conclusion: MMP11 may be a promising prognostic biomarker for pancreatic cancer patients.</p>" /> <meta name="citation_journal_title" content="Anticancer Research" /> <meta name="citation_publisher" content="International Institute of Anticancer Research" /> <meta name="citation_publication_date" content="2019/11/01" /> <meta name="citation_mjid" content="anticanres;39/11/5963" /> <meta name="citation_id" content="39/11/5963" /> <meta name="citation_public_url" content="https://ar.iiarjournals.org/content/39/11/5963" /> <meta name="citation_abstract_html_url" content="https://ar.iiarjournals.org/content/39/11/5963.abstract" /> <meta name="citation_full_html_url" content="https://ar.iiarjournals.org/content/39/11/5963.full" /> <meta name="citation_pdf_url" content="https://ar.iiarjournals.org/content/anticanres/39/11/5963.full.pdf" /> <meta name="citation_issn" content="0250-7005" /> <meta name="citation_issn" content="1791-7530" /> <meta name="citation_doi" content="10.21873/anticanres.13801" /> <meta name="citation_pmid" content="31704821" /> <meta name="citation_volume" content="39" /> <meta name="citation_issue" content="11" /> <meta name="citation_article_type" content="Research Article" /> <meta name="citation_section" content="Experimental Studies" /> <meta name="citation_firstpage" content="5963" /> <meta name="citation_lastpage" content="5971" /> <meta name="citation_author" content="JUNGWHOI LEE" /> <meta name="citation_author_institution" content="Department of Applied Life Science, SARI, Jeju National University, Jeju, Republic of Korea" /> <meta name="citation_author_email" content="sdjd1108@kaist.ac.kr" /> <meta name="citation_author_email" content="kimjh@jejunu.ac.kr" /> <meta name="citation_author" content="JUNGSUL LEE" /> <meta name="citation_author_institution" content="Department of Bio and Brain Engineering, KAIST, Daejeon, Republic of Korea" /> <meta name="citation_author" content="JAE HOON KIM" /> <meta name="citation_author_institution" content="Department of Applied Life Science, SARI, Jeju National University, Jeju, Republic of Korea" /> <meta name="citation_author_institution" content="Subtropical/tropical Organism Gene Bank, Jeju National University, Jeju, Republic of Korea" /> <meta name="citation_author_email" content="sdjd1108@kaist.ac.kr" /> <meta name="citation_author_email" content="kimjh@jejunu.ac.kr" /> <meta name="citation_reference" content="citation_journal_title=JNCI Journal of the National Cancer Institute;citation_journal_abbrev=JNCI J Natl Cancer Inst;citation_author=DP. 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Mulvihill;citation_title=Biomarkers in pancreatic adenocarcinoma: Current perspectives;citation_pages=7459-7467;citation_volume=9;citation_year=2016;citation_pmid=28003762" /> <meta name="twitter:title" content="Identification of Matrix Metalloproteinase 11 as a Prognostic Biomarker in Pancreatic Cancer" /> <meta name="twitter:card" content="summary_large_image" /> <meta name="twitter:image" content="https://ar.iiarjournals.org/sites/default/files/highwire/default/covers/acr_default_cover_0.gif" /> <meta name="twitter:description" content="Background/Aim: The aim of this study was to investigate matrix metalloproteinase 11 (MMP11) as a promising biomarker in human pancreatic cancer. Materials and Methods: A consecutive eliminating method was used to select biomarker candidates in pancreatic cancer. mRNA and protein expression levels of candidates were determined in tissues and whole blood samples of healthy donors and pancreatic cancer patients. The prognostic value of MMP11 was determined using various data-sets and Liptak's Z analysis. Results: Analysis using Gene Expression Omnibus (GEO) database showed significantly higher MMP11 mRNA expression in pancreatic cancer tissues compared to that in various normal tissues. MMP11 protein was specifically expressed in pancreatic cancer tissues, but not in various normal or other cancer tissues. Secreted MMP11 levels could be measured using easily accessible techniques and whole blood samples of pancreatic cancer. In addition, high levels of MMP11 were associated with poor prognosis of pancreatic cancer patients. Conclusion: MMP11 may be a promising prognostic biomarker for pancreatic cancer patients." /> <meta name="og-title" property="og:title" content="Identification of Matrix Metalloproteinase 11 as a Prognostic Biomarker in Pancreatic Cancer" /> <meta name="og-url" property="og:url" content="https://ar.iiarjournals.org/content/39/11/5963" /> <meta name="og-site-name" property="og:site_name" content="Anticancer Research" /> <meta name="og-description" property="og:description" content="Background/Aim: The aim of this study was to investigate matrix metalloproteinase 11 (MMP11) as a promising biomarker in human pancreatic cancer. Materials and Methods: A consecutive eliminating method was used to select biomarker candidates in pancreatic cancer. mRNA and protein expression levels of candidates were determined in tissues and whole blood samples of healthy donors and pancreatic cancer patients. The prognostic value of MMP11 was determined using various data-sets and Liptak's Z analysis. Results: Analysis using Gene Expression Omnibus (GEO) database showed significantly higher MMP11 mRNA expression in pancreatic cancer tissues compared to that in various normal tissues. MMP11 protein was specifically expressed in pancreatic cancer tissues, but not in various normal or other cancer tissues. Secreted MMP11 levels could be measured using easily accessible techniques and whole blood samples of pancreatic cancer. In addition, high levels of MMP11 were associated with poor prognosis of pancreatic cancer patients. Conclusion: MMP11 may be a promising prognostic biomarker for pancreatic cancer patients." /> <meta name="og-type" property="og:type" content="article" /> <meta name="og-image" property="og:image" content="https://ar.iiarjournals.org/sites/default/files/highwire/default/covers/acr_default_cover_0.gif" /> <link rel="shortlink" href="/node/56194" /> <link rel="shortcut icon" href="https://ar.iiarjournals.org/sites/default/files/images/favicon.ico" type="image/vnd.microsoft.icon" /> <meta name="viewport" content="width=device-width, initial-scale=1" /> <title>Identification of Matrix Metalloproteinase 11 as a Prognostic Biomarker in Pancreatic Cancer | Anticancer Research</title> <link type="text/css" rel="stylesheet" href="/sites/default/files/advagg_css/css__v18zy1wd9cHiVjdo-wati0FRJQmuO40o6b6phMXVk1M__Dt2GXI_G8k5QZN5HghvaY5_QAuh6x-qr4s3xUIUj1sA__M8F9fri-b1QX8RwJbNRiWvN_bqCXCQEG9-9ZZDMJpyg.css" media="all" /> <link type="text/css" rel="stylesheet" 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class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a"> <div class="highwire-cite-overline"><span class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">Experimental Studies</span></span></div> <div class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="anticanres;39/11/5963" data-atom-uri="/anticanres/39/11/5963.atom" data-request-view="full"></span></div> <h1 class="highwire-cite-title" id="page-title">Identification of Matrix Metalloproteinase 11 as a Prognostic Biomarker in Pancreatic Cancer</h1> <div class="highwire-cite-authors"><span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">JUNGWHOI LEE</span>, <span class="highwire-citation-author" data-delta="1">JUNGSUL LEE</span> and <span class="highwire-citation-author" data-delta="2">JAE HOON KIM</span></span></div> <div class="highwire-cite-metadata"><span class="highwire-cite-metadata-journal highwire-cite-metadata">Anticancer Research </span><span class="highwire-cite-metadata-date highwire-cite-metadata">November 2019, </span><span class="highwire-cite-metadata-volume highwire-cite-metadata">39 </span><span class="highwire-cite-metadata-issue highwire-cite-metadata">(11) </span><span class="highwire-cite-metadata-pages highwire-cite-metadata">5963-5971; </span><span class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.21873/anticanres.13801 </span></div> <div class="highwire-cite-extras"><span class="highwire-foxycart-add-to-cart-ahah highwire-foxycart-add-to-cart-ahah" data-text="Add to Cart (%short-price)" data-apath="/anticanres/39/11/5963.atom" data-type="link" data-font-icon="" data-parent-id="56005"></span></div> </div> <div id="hw-article-author-popups-top-node-56194--61716460053" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">JUNGWHOI LEE </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>1</span>Department of Applied Life Science, SARI, Jeju National University, Jeju, Republic of Korea</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=JUNGWHOI%2BLEE%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=LEE%20J&link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AJUNGWHOI%2BLEE%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-corresp-email-link last"><span>For correspondence: <a href="mailto:sdjd1108@kaist.ac.kr" class="" data-icon-position="" data-hide-link-title="0">sdjd1108@kaist.ac.kr</a> <a href="mailto:kimjh@jejunu.ac.kr" class="" data-icon-position="" data-hide-link-title="0">kimjh@jejunu.ac.kr</a></span></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">JUNGSUL LEE </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>2</span>Department of Bio and Brain Engineering, KAIST, Daejeon, Republic of Korea</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=JUNGSUL%2BLEE%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=LEE%20J&link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AJUNGSUL%2BLEE%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">JAE HOON KIM </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>1</span>Department of Applied Life Science, SARI, Jeju National University, Jeju, Republic of Korea</div><div class='author-affiliation'><span class='nlm-sup'>3</span>Subtropical/tropical Organism Gene Bank, Jeju National University, Jeju, Republic of Korea</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=JAE%2BHOON%2BKIM%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=KIM%20JH&link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AJAE%2BHOON%2BKIM%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-corresp-email-link last"><span>For correspondence: <a href="mailto:sdjd1108@kaist.ac.kr" class="" data-icon-position="" 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data-highwire-cite-ref-tooltip-instance="highwire_reflinks_tooltip" class="content-block-markup" xmlns:xhtml="http://www.w3.org/1999/xhtml"><div class="article abstract-view "><span class="highwire-journal-article-marker-start"></span><div class="section abstract" id="abstract-1"><h2>Abstract</h2><p id="p-4">Background/Aim: The aim of this study was to investigate matrix metalloproteinase 11 (MMP11) as a promising biomarker in human pancreatic cancer. Materials and Methods: A consecutive eliminating method was used to select biomarker candidates in pancreatic cancer. mRNA and protein expression levels of candidates were determined in tissues and whole blood samples of healthy donors and pancreatic cancer patients. The prognostic value of MMP11 was determined using various data-sets and Liptak's Z analysis. Results: Analysis using Gene Expression Omnibus (GEO) database showed significantly higher MMP11 mRNA expression in pancreatic cancer tissues compared to that in various normal tissues. MMP11 protein was specifically expressed in pancreatic cancer tissues, but not in various normal or other cancer tissues. Secreted MMP11 levels could be measured using easily accessible techniques and whole blood samples of pancreatic cancer. In addition, high levels of MMP11 were associated with poor prognosis of pancreatic cancer patients. Conclusion: MMP11 may be a promising prognostic biomarker for pancreatic cancer patients.</p></div><ul class="kwd-group"><li class="kwd"><a href="/keyword/mmp11" class="hw-term hw-article-keyword hw-article-keyword-mmp11" rel="nofollow">MMP11</a></li><li class="kwd"><a href="/keyword/pancreatic-cancer" class="hw-term hw-article-keyword hw-article-keyword-pancreatic-cancer" rel="nofollow">pancreatic cancer</a></li><li class="kwd"><a href="/keyword/prognosis" class="hw-term hw-article-keyword hw-article-keyword-prognosis" rel="nofollow">prognosis</a></li><li class="kwd"><a href="/keyword/biomarker" class="hw-term hw-article-keyword hw-article-keyword-biomarker" rel="nofollow">biomarker</a></li><li class="kwd"><a href="/keyword/whole-blood" class="hw-term hw-article-keyword hw-article-keyword-whole-blood" rel="nofollow">whole blood</a></li></ul><ul class="history-list"><li xmlns:hwp="http://schema.highwire.org/Journal" class="received" hwp:start="2019-09-24"><span class="received-label">Received </span>September 24, 2019.</li><li xmlns:hwp="http://schema.highwire.org/Journal" class="rev-recd" hwp:start="2019-10-02"><span class="rev-recd-label">Revision received </span>October 2, 2019.</li><li xmlns:hwp="http://schema.highwire.org/Journal" class="accepted" hwp:start="2019-10-07"><span class="accepted-label">Accepted </span>October 7, 2019.</li></ul><ul class="copyright-statement"><li class="fn" id="copyright-statement-1">Copyright漏 2019, International Institute of Anticancer Research (Dr. George J. 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class="highwire-citation-export"> <div class="highwire-citation-info"> <div class="highwire-article-citation highwire-citation-type-highwire-article cite-tool-node56194" data-node-nid="56194" id="citation-node-56194--278688668" data-pisa="anticanres;39/11/5963" data-pisa-master="anticanres;39/11/5963" data-apath="/anticanres/39/11/5963.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-standard clearfix"> <div class="highwire-cite-title">Identification of Matrix Metalloproteinase 11 as a Prognostic Biomarker in Pancreatic Cancer</div> <div class="highwire-cite-authors"><span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">JUNGWHOI</span> <span class="nlm-surname">LEE</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">JUNGSUL</span> <span class="nlm-surname">LEE</span></span>, <span class="highwire-citation-author" 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data-apath="/anticanres/39/11/5963.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-standard clearfix"> <div class="highwire-cite-title">Identification of Matrix Metalloproteinase 11 as a Prognostic Biomarker in Pancreatic Cancer</div> <div class="highwire-cite-authors"><span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">JUNGWHOI</span> <span class="nlm-surname">LEE</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">JUNGSUL</span> <span class="nlm-surname">LEE</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">JAE HOON</span> <span class="nlm-surname">KIM</span></span></span></div> <div class="highwire-cite-metadata"><span class="highwire-cite-metadata-journal highwire-cite-metadata">Anticancer Research </span><span class="highwire-cite-metadata-date highwire-cite-metadata">Nov 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