Cell Sorters and Single Cell Dispensers

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Scientists</h2></div> </div> </div> </div> <div> <div class="paragraph paragraph--type--card-paragraph paragraph--view-mode--default card-para-default"> <div class="row card_row"> <div class="col-md-6"> <div class="h-100"> <div class="d-flex flex-column h-100"> <a href="/resources/testimonials/from-your-peers-development-of-crispr-edited-cell-line-models-with-single-cell-dispenser" > <div class="card-img-top text-center mb-3" style="background-repeat: no-repeat; background-color: #f5f5f5; height:200px; width: 100%;"> <div class="teaser-valign-container" style=""> <div class="valign"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/oscar-perez-leal-headshot-525x300.png" alt="Dr. Oscar Perez-Leal describes how his team leveraged a Bio-Techne Single Cell Sorter and Single Cell Dispenser to improve clonal outgrowth of CRISPR-edited cells. " loading="lazy" > </div> </div> </div> </a> <a class="card_title_link" href="/resources/testimonials/from-your-peers-development-of-crispr-edited-cell-line-models-with-single-cell-dispenser" > <h3 class="card_title_htag"></h3> </a> <div class="card_description flex-grow-1"> <div><p><strong>Dr. Oscar Perez-Leal from Temple University </strong>describes how his team leveraged a Bio-Techne Single Cell Dispenser to improve clonal outgrowth of CRISPR-edited cells.</p></div> </div> <div class="card-bottom-link"> <div> <a href="/resources/testimonials/from-your-peers-development-of-crispr-edited-cell-line-models-with-single-cell-dispenser" > Read Article </a> </div> </div> </div> </div> </div> <div class="col-md-6"> <div class="h-100"> <div class="d-flex flex-column h-100"> <a href="/resources/literature/cell-line-development-for-biopharmaceutical-production-using-namocell-single-cell-dispenser" > <div class="card-img-top text-center mb-3" style="background-repeat: no-repeat; background-color: #f5f5f5; height:200px; width: 100%;"> <div class="teaser-valign-container" style=""> <div class="valign"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/lina-chakrabarti-headshot-525x300.png" alt="Dr. Lina Chakrabarti from AstraZeneca discusses how the single cell sorting dispensing technology on the Pala™ system boosted cell line development workflows for biopharmaceutical manufacturing. " loading="lazy" > </div> </div> </div> </a> <a class="card_title_link" href="/resources/literature/cell-line-development-for-biopharmaceutical-production-using-namocell-single-cell-dispenser" > <h3 class="card_title_htag"></h3> </a> <div class="card_description flex-grow-1"> <div><p><strong>Dr. Lina Chakrabarti from AstraZeneca</strong> discusses how the single cell dispenser technology on the Pala™ system boosted cell line development workflows for biopharmaceutical manufacturing.<a name="technology"></a></p></div> </div> <div class="card-bottom-link"> <div> <a href="/resources/literature/cell-line-development-for-biopharmaceutical-production-using-namocell-single-cell-dispenser" > Read Article </a> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="thin-banner banner_wrapper"> <div class="banner-dark"> <div> <div><h2>Interested in cell sorting or cell isolation?</h2></div> <a href="#form" > <button type="button" class="btn btn-primary"> Request Information </button> </a> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--_-2-text-to-media mb-4 paragraph--view-mode--default"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_text_to_media:field_header_2_global"> <div><h2>Sort Cells According to Your Requirements</h2></div> </div> <div class="field_block:paragraph:2_2_text_to_media:field_lg_sngl_frmtd_text_global"> <div><h4><strong>Leverage the powerful combination of microfluidics, flow cytometry, and liquid dispensing in the Pala system to: </strong></h4> <ul> <li>Get single cells dispensed into 96- or 384-well plates with the <strong>Single Cell Sorting Mode</strong></li> <li>Isolate rare cells from large populations with the <strong>Enrichment Mode</strong></li> <li>Easily sort tens of thousands of cells with the <strong>Bulk Sorting Mode</strong></li> </ul> <p><strong>Microfluidics in a Cartridge: </strong>Sterile, disposable, enables single cell sorting</p> <p><strong>Flow Cytometry: </strong>Cell viability ensured, no prior experience with flow cytometry needed</p> <p><strong>Liquid Dispensing: </strong>Cells dispensed into 97- or 384-well plates in minutes</p></div> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_text_to_media:field_indv_media"> <div> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/pala-three-sort-dispense-technologies-525x300-v2.png" alt="The Bio-Techne Pala Cell Sorter and Single Cell Dispenser employs three technologies for single cell sorting and dispensing: microfluidics, flow cytometry, and liquid cell dispensing." loading="lazy" > </div> </div> <div class="field_block:paragraph:2_2_text_to_media:field_image_caption"> <div>A. Microfluidics, B. Flow Cytometry, C. Liquid Dispensing</div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--section paragraph--view-mode--default mb-4"> <div> <div> <div class="paragraph paragraph--type--header"> <div> <div><h2>Featured Resources</h2></div> </div> </div> </div> <div> <div class="paragraph paragraph--type--_-3-media-to-text paragraph--view-mode--default mb-4"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--25-75"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:1_3_media_to_text:field_indv_media"> <div> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/lg-high-titer-lgG-clone-graph-400x235.png" alt="Graph showing enrichment High-Titer lgG Clones enabled by the Pala Single Cell Sorting and Dispensing system from Bio-Techne." loading="lazy" > </div> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:1_3_media_to_text:field_header_2_global"> <div><h3>Enriching High Titer IgG-producing Clones Application Note</h3></div> </div> <div class="field_block:paragraph:1_3_media_to_text:field_lg_sngl_frmtd_text_global"> <div><p>Cold capture coupled with the Pala single cell sorting system enables enrichment of high-titer IgG clones.</p></div> </div> <div class="field_block:paragraph:1_3_media_to_text:field_call_to_action_global"> <a href="/resources/testimonials/from-your-peers-development-of-crispr-edited-cell-line-models-with-single-cell-dispenser" class="btn btn-primary" type="link"> Read Application Note </a> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--_-3-media-to-text paragraph--view-mode--default mb-4"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--25-75"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:1_3_media_to_text:field_indv_media"> <div> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/lg-single-cell-isolation-graph-400x235.png" alt="Graph displaying Single Cell Isolation enabled by the Bio-Techne Pala Cell Sorter and Single Cell Dispenser" loading="lazy" > </div> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:1_3_media_to_text:field_header_2_global"> <div><h3>Single Cell Isolation with Minimal Sample Input Application Note</h3></div> </div> <div class="field_block:paragraph:1_3_media_to_text:field_lg_sngl_frmtd_text_global"> <div><p>Isolate single cells from a population as small as 100 cells.</p></div> </div> <div class="field_block:paragraph:1_3_media_to_text:field_call_to_action_global"> <a href="/resources/literature/minimal-sample-input-and-high-cell-recovery-with-the-bio-techne-single-cell-dispense" class="btn btn-primary" type="link"> Read Application Note </a> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--section paragraph--view-mode--default mb-4"> <div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><h2>Pala Cell Sorter/Single Cell Dispensers vs Conventional Cell Sorters</h2> <p>See how Pala compares with fluorescence-activated cell sorting (FACS)</p> <figure class="responsive-figure-table"><table class="overflow-auto table table-bordered"> <thead> <tr> <th> </th> <th>Namocell Single Cell Dispensers</th> <th>Traditional Cell Dispensers</th> </tr> </thead> <tbody> <tr> <td><strong>Pressure</strong></td> <td>Less than 2 psi</td> <td>20 - 70 psi</td> </tr> <tr> <td><strong>Initiation time</strong></td> <td>2 - 3 min</td> <td>30 - 45 min</td> </tr> <tr> <td><strong>Processing speed</strong></td> <td>2 - 50,000 cells/second</td> <td>2,000 - 20,000 cells/second</td> </tr> <tr> <td><strong>Fluorescence channels</strong></td> <td>Up to 11</td> <td>16</td> </tr> <tr> <td><strong>Minimum input</strong></td> <td>100 cells</td> <td>200,000 cells</td> </tr> <tr> <td><strong>Droplet size</strong></td> <td>1 µL</td> <td>0.001 - 0.005 µL</td> </tr> <tr> <td><strong>Sheath</strong></td> <td>6.5 mL/hr</td> <td>1 - 2 L/hr</td> </tr> <tr> <td><strong>Sterile sorting</strong></td> <td>Easy</td> <td>Difficult</td> </tr> <tr> <td><strong>96-well sorting</strong></td> <td>Standard</td> <td>Optional</td> </tr> <tr> <td><strong>System clogging</strong></td> <td>No</td> <td>Yes</td> </tr> <tr> <td><strong>Cost</strong></td> <td>$</td> <td>$$$</td> </tr> </tbody> </table></figure></div> </div> </div> <div> <div class="paragraph paragraph--type--individual-button mb-4 paragraph--view-mode--default w-100"> <div class="row"> <div class="col"> <a href="#form" class="btn btn-primary float-left" type="link" > Request Demo and Information </a> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--full-page-text-with-media mb-4 paragraph--view-mode--default"> <div><h2>Accelerate Your Workflow</h2></div> <div> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/single-cell-dispenser-workflow-1470x400-v2.png" alt="Pala Single Cell Sorting and Single Cell Dispensing instrument workflow vs. traditional FACS workflow" loading="lazy" > </div> <div><p><sup>*</sup>Chakrabarti, Lina, <em>et al.</em> “Simplifying Stable CHO Cell Line Generation with High Probability of Monoclonality by Using Microfluidic Dispensing as an Alternative to Fluorescence Activated Cell Sorting.” Biotechnology Progress, 10 Mar. 2024, <a href="https://doi.org/10.1002/btpr.3441" target="_blank">https://doi.org/10.1002/btpr.3441</a>. Accessed 11 Apr. 2024.</p></div> </div> </div> <div> <div class="thin-banner banner_wrapper"> <div class="banner-dark"> <div> <div><h2>Ready to collect your cells in as little as 7 minutes?</h2></div> <a href="#form" > <button type="button" class="btn btn-primary"> Request Information </button> </a> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--clickable-icons-container paragraph--view-mode--default"> <div class="container"> <div class="row"> <div class="col p-0 "> <h2></h2> </div> </div> <div class="row"> <div class="col "> <div><h2><a name="applications"></a>Applications of the Pala Single Cell Sorting and Dispensing System</h2> <p>Click an icon below to learn more about how the Pala system empower modern research and therapeutics. You will be redirected to the original Namocell webpage.</p></div> </div> </div> <div class="row"> <div class="row"> <div class="col-xl-2 col-lg-2 col-md-4 col-sm-6 col-6 mb-4"> <div class="paragraph paragraph--type--indvidual-clickable-icon paragraph--view-mode--default card p-3 text-center h-100 mb-0"> <a href="/resources/instrument-applications/crispr-cell-engineering-single-cell-dispenser" > <div><article> <div><img src='https://resources.bio-techne.com/bio-techne-assets/images/research-areas/crispr-cell-eng-icon.png' alt='Bio-techne instruments can be applied to utilize CRISPR and iPSC cloning'></div> </article> </div> <p><strong>CRISPR and Cell Engineering</strong></p> </a> </div> </div> <div class="col-xl-2 col-lg-2 col-md-4 col-sm-6 col-6 mb-4"> <div class="paragraph paragraph--type--indvidual-clickable-icon paragraph--view-mode--default card p-3 text-center h-100 mb-0"> <a href="/resources/instrument-applications/cell-line-development-single-cell-dispenser" > <div><article> <div><img src='https://resources.bio-techne.com/bio-techne-assets/images/research-areas/cell-line-dev-icon.png' alt='Bio-Techne instruments can be applied to develop cell lines'></div> </article> </div> <p><strong>Cell Line Development</strong></p> </a> </div> </div> <div class="col-xl-2 col-lg-2 col-md-4 col-sm-6 col-6 mb-4"> <div class="paragraph paragraph--type--indvidual-clickable-icon paragraph--view-mode--default card p-3 text-center h-100 mb-0"> <a href="/resources/instrument-applications/single-cell-genomics-single-cell-dispenser" > <div><article> <div><img src='https://resources.bio-techne.com/bio-techne-assets/images/research-areas/single-cell-genomics-icon.png' alt='Bio-Techne instruments can be applied to study single cell genomics'></div> </article> </div> <p><strong>Single Cell Genomics</strong></p> </a> </div> </div> <div class="col-xl-2 col-lg-2 col-md-4 col-sm-6 col-6 mb-4"> <div class="paragraph paragraph--type--indvidual-clickable-icon paragraph--view-mode--default card p-3 text-center h-100 mb-0"> <a href="/resources/instrument-applications/antibody-discovery-single-cell-dispenser" > <div><article> <div><img src='https://resources.bio-techne.com/bio-techne-assets/images/research-areas/antibody-disc-icon.png' alt='Bio-Techne instruments can be applied to develop antibodies'></div> </article> </div> <p><strong>Antibody Discovery</strong></p> </a> </div> </div> <div class="col-xl-2 col-lg-2 col-md-4 col-sm-6 col-6 mb-4"> <div class="paragraph paragraph--type--indvidual-clickable-icon paragraph--view-mode--default card p-3 text-center h-100 mb-0"> <a href="/resources/instrument-applications/rare-cell-isolation-single-cell-dispenser" > <div><article> <div><img src='https://resources.bio-techne.com/bio-techne-assets/images/research-areas/rare-cell-isolation-icon.png' alt='Bio-Techne instruments can be applied to isolate rare cells'></div> </article> </div> <p><strong>Rare Cell Isolation</strong></p> </a> </div> </div> </div> </div> </div> </div> </div> <div> <section class="paragraph paragraph--type--full-width-banner-with-image mb-4 paragraph--view-mode--default paragraph-background-color--"> <div class="banner_background_image" data-bgimage="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/covid19-products-banner-background-1110x240.jpg" style="background-repeat: no-repeat;"> <div> <div> <div> <div class="paragraph paragraph--type--_-2-media-to-text mb-4 paragraph--view-mode--default"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_media_to_text:field_indv_media"> <div> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/stem-cell-cluster-for-cept-cocktail.png" alt="Stem Cell Cluster for CEPT Cocktail" loading="lazy" > </div> </div> </div> </div> <div class="layout__region 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<div class="col-md-6"> <div class="h-100"> <div class="d-flex flex-column h-100"> <a href="/p/cell-sorting-and-single-cell-dispensing/pala_ni006" > <div class="card-img-top text-center mb-3" style="background-repeat: no-repeat; background-color: #f5f5f5; height:200px; width: 100%;"> <div class="teaser-valign-container" style=""> <div class="valign"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/bt-pala-instrument-525x300-v2.png" alt="Bio-Techne Pala Cell Sorter and Single Cell Dispenser" loading="lazy" > </div> </div> </div> </a> <a class="card_title_link" href="/p/cell-sorting-and-single-cell-dispensing/pala_ni006" > <h3 class="card_title_htag"> <div>The Pala System</div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>For more comprehensive cellular analysis needing multiple markers, use the dual-laser Pala system</p></div> </div> <div class="card-bottom-link"> <div> <a href="/p/cell-sorting-and-single-cell-dispensing/pala_ni006" > Learn About Pala </a> </div> </div> </div> </div> </div> <div class="col-md-6"> <div class="h-100"> <div class="d-flex flex-column h-100"> <a href="/search?keywords=Cell%20Sorting%20and%20Single%20Cell%20Dispensing%20Consumables&sub_category=Cell%20Sorting%20and%20Single%20Cell%20Dispensing%20Consumables&compatible_instrument=Pala&view=condensed" > <div class="card-img-top text-center mb-3" style="background-repeat: no-repeat; background-color: #f5f5f5; height:200px; width: 100%;"> <div class="teaser-valign-container" style=""> <div class="valign"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/bt-microfluidic-cell-cartridge-525x300.png" alt="Disposable microfluidic cell cartridge used with the Bio-Techne Pala Cell Sorter and Single Cell Dispenser" loading="lazy" > </div> </div> </div> </a> <a class="card_title_link" 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