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<span class="hide tagmanagervalue" data-attribute="publishDate" data-value="November 19, 2024" data-type="string"></span> <div class="issue--info"> <a class="issue--journal-rss is-b" href="/rss/site_3/67.xml"></a> <h1 class="issue--text fw-5"> <span><strong>November 19, 2024</strong>,</span> <span>Vol 332,</span> <span>No. 19,</span> <span>Pages </span>1595<span>-</span>1682 </h1> </div> <div id="this-week-in-jama" class="issue-group group--this-week-in-jama"><div class="article-type-group thm-col">This Week in JAMA</div> <div class="issue-group-articles"> <div class="article"> <div class="nopdf"></div> <h3 class="article--title"> <a href="https://jamanetwork.com/journals/jama/fullarticle/2825493">Audio Highlights<span class="subtitle"><span class="colon-for-citation-subtitle">: </span>October 19-25, 2024</span></a> </h3> <div class="article--links"> <a class="article--abstract" href="https://jamanetwork.com/journals/jama/article-abstract/2825493">Abstract</a> <a class="article--full-text" href="https://jamanetwork.com/journals/jama/fullarticle/2825493">Full Text</a> </div> <div class="badges"> <span class="badge icon-free"><span class="sr-t">free access</span></span> <span class="badge icon-online_only"><span class="sr-t">online only</span></span> <span class="badge icon-audio"><span class="sr-t">has audio</span></span> </div> <div class="article--citation"> <em>JAMA.</em> <span class="meta-citation"> 2024;332(19):e2318437. doi:10.1001/jama.2023.18437</span> </div> <ul class="article--linked-audios no-bullet ml0 mt05"> <li class="article--linked-audio"> <div class="article--author-interview fw-b"> <a href="https://jamanetwork.com/learning/audio-player/18922516" target="_blank"><i class="icon-podcast black"></i></a> <div class="article--author-interview-text text-small"> <a href="https://jamanetwork.com/learning/audio-player/18922516" target="_blank" class="thm-col">Podcast:</a> Declaration of Helsinki Revision, Fewer Chemotherapy Cycles for Retinoblastoma, Staffing in Dialysis Centers, and more </div> </div> </li> </ul> </div> </div> </div> <div class="movable-ad-target"> </div> <div id="original-investigation" class="issue-group group--original-investigation"><div class="article-type-group thm-col">Original Investigation</div> <div class="issue-group-articles"> <div class="article"> <h4 class="superClassification">Caring for the Critically Ill Patient</h4> <a class="pdf pdfaccess js-pdfaccess" href="https://jamanetwork.com/journals/jama/articlepdf/2824930/jama_taccone_2024_oi_240114_1731080344.08481.pdf" title="PDF of article" data-article-id="2824930" data-article-url="https://jamanetwork.com/journals/jama/articlepdf/2824930/jama_taccone_2024_oi_240114_1731080344.08481.pdf" data-ajax-url="/Content/CheckPdfAccess"></a> <h3 class="article--title"> <a href="https://jamanetwork.com/journals/jama/fullarticle/2824930">Restrictive vs Liberal Transfusion Strategy in Patients With Acute Brain Injury<span class="subtitle"><span class="colon-for-citation-subtitle">: </span>The TRAIN Randomized Clinical Trial</span></a> </h3> <div class="article--authors"> Fabio Silvio&#160;Taccone,&#160;MD, PhD; Carla&#160;Rynkowski Bittencourt,&#160;MD, PhD; Kirsten&#160;M&#248;ller,&#160;MD, PhD; et al. </div> <div class="article--links"> <a class="article--abstract" href="https://jamanetwork.com/journals/jama/article-abstract/2824930">Abstract</a> <a class="article--full-text" href="https://jamanetwork.com/journals/jama/fullarticle/2824930">Full Text</a> </div> <div class="badges"> <span class="badge icon-quiz_cme"><span class="sr-t">has active quiz</span></span> <span class="badge icon-audio"><span class="sr-t">has audio</span></span> </div> <div class="article--citation"> <em>JAMA.</em> <span class="meta-citation"> 2024;332(19):1623-1633. doi:10.1001/jama.2024.20424</span> </div> <div class="article--excerpt"><p class="para">This randomized clinical trial assesses the effect of a liberal vs a restrictive hemoglobin threshold for red blood cell transfusion on unfavorable neurological outcome in patients with acute brain injury.</p></div> <ul class="article--linked-audios no-bullet ml0 mt05"> <li class="article--linked-audio"> <div class="article--author-interview fw-b"> <a href="https://jamanetwork.com/learning/audio-player/18918603" target="_blank"><i class="icon-podcast black"></i></a> <div class="article--author-interview-text text-small"> <a href="https://jamanetwork.com/learning/audio-player/18918603" target="_blank" class="thm-col">Podcast:</a> JAMA Critical Care Research at ESICM Congress 2024 </div> </div> </li> </ul> <ul class="article--linked-articles"> <li class="linked-article--article editorial"> <div class="linked-article--type thm-col">Editorial</div> <a class="linked-article--title angled-line" href="https://jamanetwork.com/journals/jama/fullarticle/2824932">Shifting Balance of the Risk-Benefit of Restrictive Transfusion Strategies in Neurocritically Ill Patients—Is Less Still More?</a> <div class="linked-article--authors"> Alexis F.&#160;Turgeon,&#160;MD, MSc; Fran&#231;ois&#160;Lauzier,&#160;MD, MSc </div> <div class="linked-article--journal-name"> JAMA </div> <ul class="article--linked-audios no-bullet ml0 mt05"> <li class="article--linked-audio"> <div class="article--author-interview fw-b"> <a href="https://jamanetwork.com/learning/audio-player/18918603" target="_blank"><i class="icon-podcast black"></i></a> <div class="article--author-interview-text text-small"> <a href="https://jamanetwork.com/learning/audio-player/18918603" target="_blank" class="thm-col">Podcast:</a> JAMA Critical Care Research at ESICM Congress 2024 </div> </div> </li> </ul> </li> </ul> </div> <div class="article"> <a class="pdf pdfaccess js-pdfaccess" href="https://jamanetwork.com/journals/jama/articlepdf/2825162/jama_ye_2024_oi_240113_1731080348.59663.pdf" title="PDF of article" data-article-id="2825162" data-article-url="https://jamanetwork.com/journals/jama/articlepdf/2825162/jama_ye_2024_oi_240113_1731080348.59663.pdf" data-ajax-url="/Content/CheckPdfAccess"></a> <h3 class="article--title"> <a href="https://jamanetwork.com/journals/jama/fullarticle/2825162">Three vs 6 Cycles of Chemotherapy for High-Risk Retinoblastoma<span class="subtitle"><span class="colon-for-citation-subtitle">: </span>A Randomized Clinical Trial</span></a> </h3> <div class="article--authors"> Huijing&#160;Ye,&#160;MD, PhD; Kang&#160;Xue,&#160;MD; Ping&#160;Zhang,&#160;MD, PhD; et al. </div> <div class="article--links"> <a class="article--abstract" href="https://jamanetwork.com/journals/jama/article-abstract/2825162">Abstract</a> <a class="article--full-text" href="https://jamanetwork.com/journals/jama/fullarticle/2825162">Full Text</a> </div> <div class="article--citation"> <em>JAMA.</em> <span class="meta-citation"> 2024;332(19):1634-1641. doi:10.1001/jama.2024.19981</span> </div> <div class="article--excerpt"><p class="para">This randomized clinical trial examines whether 3 cycles of carboplatin, etoposide, and vincristine chemotherapy is noninferior to 6 cycles for enucleated unilateral retinoblastoma with high-risk pathological features.</p></div> <ul class="article--linked-articles"> <li class="linked-article--article editorial"> <div class="linked-article--type thm-col">Editorial</div> <a class="linked-article--title angled-line" href="https://jamanetwork.com/journals/jama/fullarticle/2825271">Meeting the Unmet Needs in Rare Cancer<span class="subtitle"><span class="colon-for-citation-subtitle">: </span>Advancing Treatment Options for Retinoblastoma and Beyond</span></a> <div class="linked-article--authors"> Ning&#160;Li,&#160;MD; Shuhang&#160;Wang,&#160;MD; Guo&#160;Zhao,&#160;MD </div> <div class="linked-article--journal-name"> JAMA </div> </li> <li class="linked-article--article invited-commentary"> <div class="linked-article--type thm-col">Invited Commentary</div> <a class="linked-article--title angled-line" href="https://jamanetwork.com/journals/jama/fullarticle/2825227">Three vs 6 Cycles of Adjuvant Chemotherapy for Retinoblastoma</a> <div class="linked-article--authors"> Ann M.&#160;Leahey,&#160;MD; Amish&#160;Shah,&#160;MD, PhD; Carol L.&#160;Shields,&#160;MD </div> <div class="linked-article--journal-name"> JAMA Ophthalmol </div> </li> </ul> </div> <div class="article"> <a class="pdf pdfaccess js-pdfaccess" href="https://jamanetwork.com/journals/jama/articlepdf/2824276/jama_lee_2024_oi_240098_1731080352.26956.pdf" title="PDF of article" data-article-id="2824276" data-article-url="https://jamanetwork.com/journals/jama/articlepdf/2824276/jama_lee_2024_oi_240098_1731080352.26956.pdf" data-ajax-url="/Content/CheckPdfAccess"></a> <h3 class="article--title"> <a href="https://jamanetwork.com/journals/jama/fullarticle/2824276">Screening for <i>Helicobacter pylori</i> to Prevent Gastric Cancer<span class="subtitle"><span class="colon-for-citation-subtitle">: </span>A Pragmatic Randomized Clinical Trial</span></a> </h3> <div class="article--authors"> Yi-Chia&#160;Lee,&#160;MD, PhD; Tsung-Hsien&#160;Chiang,&#160;MD, PhD; Han-Mo&#160;Chiu,&#160;MD, PhD; et al. </div> <div class="article--links"> <a class="article--abstract" href="https://jamanetwork.com/journals/jama/article-abstract/2824276">Abstract</a> <a class="article--full-text" href="https://jamanetwork.com/journals/jama/fullarticle/2824276">Full Text</a> </div> <div class="badges"> <span class="badge icon-audio"><span class="sr-t">has audio</span></span> </div> <div class="article--citation"> <em>JAMA.</em> <span class="meta-citation"> 2024;332(19):1642-1651. doi:10.1001/jama.2024.14887</span> </div> <div class="article--excerpt"><p class="para">This randomized clinical trial evaluates the effects of <i>Helicobacter pylori</i> stool antigen assessment plus fecal immunochemical testing (FIT), vs FIT alone, on gastric cancer incidence and mortality among adults in Taiwan.</p></div> <ul class="article--linked-audios no-bullet ml0 mt05"> <li class="article--linked-audio"> <div class="article--author-interview fw-b"> <a href="https://jamanetwork.com/learning/audio-player/18915757" target="_blank"><i class="icon-podcast black"></i></a> <div class="article--author-interview-text text-small"> <a href="https://jamanetwork.com/learning/audio-player/18915757" target="_blank" class="thm-col">Podcast:</a> Fecal Immunochemical Test (FIT) and Helicobacter pylori Stool Antigen Co-Testing for Gastric Cancer </div> </div> </li> </ul> <ul class="article--linked-articles"> <li class="linked-article--article editorial"> <div class="linked-article--type thm-col">Editorial</div> <a class="linked-article--title angled-line" href="https://jamanetwork.com/journals/jama/fullarticle/2824280">Fecal Immunochemical Test and <i>Helicobacter pylori</i> Stool Antigen Co-Testing<span class="subtitle"><span class="colon-for-citation-subtitle">: </span>A Potential 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Constanza&#160;Camargo,&#160;PhD, MSc, MHA </div> <div class="linked-article--journal-name"> JAMA </div> <ul class="article--linked-audios no-bullet ml0 mt05"> <li class="article--linked-audio"> <div class="article--author-interview fw-b"> <a href="https://jamanetwork.com/learning/audio-player/18915757" target="_blank"><i class="icon-podcast black"></i></a> <div class="article--author-interview-text text-small"> <a href="https://jamanetwork.com/learning/audio-player/18915757" target="_blank" class="thm-col">Podcast:</a> Fecal Immunochemical Test (FIT) and Helicobacter pylori Stool Antigen Co-Testing for Gastric Cancer </div> </div> </li> </ul> </li> </ul> </div> </div> </div> <div id="research-letter" class="issue-group group--research-letter"><div class="article-type-group thm-col">Research Letter</div> <div class="issue-group-articles"> <div class="article"> <a class="pdf pdfaccess js-pdfaccess" href="https://jamanetwork.com/journals/jama/articlepdf/2825312/jama_li_2024_ld_240068_1731080365.47439.pdf" title="PDF of article" data-article-id="2825312" data-article-url="https://jamanetwork.com/journals/jama/articlepdf/2825312/jama_li_2024_ld_240068_1731080365.47439.pdf" data-ajax-url="/Content/CheckPdfAccess"></a> <h3 class="article--title"> <a href="https://jamanetwork.com/journals/jama/fullarticle/2825312">GLP-1 Receptor Agonist and SGLT2 Inhibitor Prescribing in People With Type 1 Diabetes</a> </h3> <div class="article--authors"> Piaopiao&#160;Li,&#160;MS; Zhiyan&#160;Li,&#160;MPH; Elizabeth&#160;Staton,&#160;BA; et al. </div> <div class="article--links"> <a class="article--abstract" href="https://jamanetwork.com/journals/jama/article-abstract/2825312">Abstract</a> <a class="article--full-text" href="https://jamanetwork.com/journals/jama/fullarticle/2825312">Full Text</a> </div> <div class="article--citation"> <em>JAMA.</em> <span class="meta-citation"> 2024;332(19):1667-1669. doi:10.1001/jama.2024.18581</span> </div> <div class="article--excerpt"><p class="para">This pooled cross-sectional study explores prescribing rates for glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter 2 inhibitors among US patients with type 1 diabetes.</p></div> </div> <div class="article"> <a class="pdf pdfaccess js-pdfaccess" href="https://jamanetwork.com/journals/jama/articlepdf/2824688/jama_collier_2024_ld_240078_1731080363.34598.pdf" title="PDF of article" data-article-id="2824688" data-article-url="https://jamanetwork.com/journals/jama/articlepdf/2824688/jama_collier_2024_ld_240078_1731080363.34598.pdf" data-ajax-url="/Content/CheckPdfAccess"></a> <h3 class="article--title"> <a href="https://jamanetwork.com/journals/jama/fullarticle/2824688">Decline of Mpox Antibody Responses After Modified Vaccinia Ankara–Bavarian Nordic Vaccination</a> </h3> <div class="article--authors"> Ai-ris Y.&#160;Collier,&#160;MD; Katherine&#160;McMahan,&#160;MS; Catherine&#160;Jacob-Dolan,&#160;PhD; et al. </div> <div class="article--links"> <a class="article--abstract" href="https://jamanetwork.com/journals/jama/article-abstract/2824688">Abstract</a> <a class="article--full-text" href="https://jamanetwork.com/journals/jama/fullarticle/2824688">Full Text</a> </div> <div class="badges"> <span class="badge icon-free"><span class="sr-t">free access</span></span> <span class="badge icon-audio"><span class="sr-t">has audio</span></span> </div> <div class="article--citation"> <em>JAMA.</em> <span class="meta-citation"> 2024;332(19):1669-1672. doi:10.1001/jama.2024.20951</span> </div> <div class="article--excerpt"><p class="para">This study assesses mpox-specific immune responses for 12 months after MVA-BN vaccination.</p></div> <ul class="article--linked-audios no-bullet ml0 mt05"> <li class="article--linked-audio"> <div class="article--author-interview fw-b"> <a href="https://jamanetwork.com/learning/audio-player/18929551" target="_blank"><i class="icon-podcast black"></i></a> <div class="article--author-interview-text text-small"> <a href="https://jamanetwork.com/learning/audio-player/18929551" target="_blank" class="thm-col">Podcast:</a> Mpox Treatment Strategies, Clinical Presentation, and Diagnostic Approaches </div> </div> </li> </ul> </div> </div> </div> <div id="viewpoint" class="issue-group group--viewpoint"><div class="article-type-group thm-col">Viewpoint</div> <div class="issue-group-articles"> <div class="article"> <h4 class="superClassification">Health and the 2024 US Election</h4> <a class="pdf pdfaccess js-pdfaccess" href="https://jamanetwork.com/journals/jama/articlepdf/2823961/jama_shachar_2024_vp_240115_1731080337.72966.pdf" title="PDF of article" data-article-id="2823961" data-article-url="https://jamanetwork.com/journals/jama/articlepdf/2823961/jama_shachar_2024_vp_240115_1731080337.72966.pdf" data-ajax-url="/Content/CheckPdfAccess"></a> <h3 class="article--title"> <a href="https://jamanetwork.com/journals/jama/fullarticle/2823961">Preventive Care Coverage Threatened by Federal Court Ruling</a> </h3> <div class="article--authors"> Carmel&#160;Shachar,&#160;JD, MPH; 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