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2021-22 Catalog | Caltech Academic Catalog
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d-flex flex-column menu-item"> <div class="sidebar-menu-block__level-2__item__wrapper "> <a class="sidebar-menu-block__level-2__link" href="/archive/2021-22/department/IST/"> Information Science and Technology </a> </div> </li> <li class="sidebar-menu-block__level-2__item d-flex flex-column menu-item"> <div class="sidebar-menu-block__level-2__item__wrapper "> <a class="sidebar-menu-block__level-2__link" href="/archive/2021-22/department/L/"> Languages </a> </div> </li> <li class="sidebar-menu-block__level-2__item d-flex flex-column menu-item"> <div class="sidebar-menu-block__level-2__item__wrapper "> <a class="sidebar-menu-block__level-2__link" href="/archive/2021-22/department/Law/"> Law </a> </div> </li> <li class="sidebar-menu-block__level-2__item d-flex flex-column menu-item"> <div class="sidebar-menu-block__level-2__item__wrapper "> <a class="sidebar-menu-block__level-2__link" href="/archive/2021-22/department/MS/"> Materials Science </a> </div> </li> <li class="sidebar-menu-block__level-2__item d-flex flex-column menu-item"> <div class="sidebar-menu-block__level-2__item__wrapper "> <a class="sidebar-menu-block__level-2__link" href="/archive/2021-22/department/Ma/"> Mathematics </a> </div> </li> <li class="sidebar-menu-block__level-2__item d-flex flex-column menu-item"> <div class="sidebar-menu-block__level-2__item__wrapper "> <a class="sidebar-menu-block__level-2__link" href="/archive/2021-22/department/ME/"> Mechanical Engineering </a> </div> </li> <li class="sidebar-menu-block__level-2__item d-flex flex-column menu-item"> <div class="sidebar-menu-block__level-2__item__wrapper "> <a class="sidebar-menu-block__level-2__link" href="/archive/2021-22/department/MedE/"> Medical Engineering </a> </div> </li> <li class="sidebar-menu-block__level-2__item d-flex flex-column menu-item"> <div class="sidebar-menu-block__level-2__item__wrapper "> <a class="sidebar-menu-block__level-2__link" href="/archive/2021-22/department/Mu/"> Music </a> </div> </li> <li class="sidebar-menu-block__level-2__item d-flex flex-column menu-item"> <div class="sidebar-menu-block__level-2__item__wrapper "> <a class="sidebar-menu-block__level-2__link" href="/archive/2021-22/department/NB/"> Neurobiology </a> </div> </li> <li class="sidebar-menu-block__level-2__item d-flex flex-column menu-item"> <div class="sidebar-menu-block__level-2__item__wrapper "> <a class="sidebar-menu-block__level-2__link" href="/archive/2021-22/department/PVA/"> Performing and Visual Arts </a> </div> </li> <li class="sidebar-menu-block__level-2__item d-flex flex-column menu-item"> <div class="sidebar-menu-block__level-2__item__wrapper "> <a class="sidebar-menu-block__level-2__link" href="/archive/2021-22/department/Pl/"> Philosophy </a> </div> </li> <li class="sidebar-menu-block__level-2__item d-flex flex-column menu-item"> <div class="sidebar-menu-block__level-2__item__wrapper "> <a class="sidebar-menu-block__level-2__link" href="/archive/2021-22/department/PE/"> Physical Education </a> </div> </li> <li class="sidebar-menu-block__level-2__item d-flex flex-column menu-item"> <div class="sidebar-menu-block__level-2__item__wrapper "> <a class="sidebar-menu-block__level-2__link" href="/archive/2021-22/department/Ph/"> Physics </a> </div> </li> <li class="sidebar-menu-block__level-2__item d-flex flex-column menu-item"> <div class="sidebar-menu-block__level-2__item__wrapper "> <a class="sidebar-menu-block__level-2__link" href="/archive/2021-22/department/PS/"> Political Science </a> </div> </li> <li class="sidebar-menu-block__level-2__item d-flex flex-column menu-item"> <div class="sidebar-menu-block__level-2__item__wrapper "> <a class="sidebar-menu-block__level-2__link" href="/archive/2021-22/department/Psy/"> Psychology </a> </div> </li> <li class="sidebar-menu-block__level-2__item d-flex flex-column menu-item"> <div class="sidebar-menu-block__level-2__item__wrapper "> <a class="sidebar-menu-block__level-2__link" href="/archive/2021-22/department/SEC/"> Scientific and Engineering Communication </a> </div> </li> <li class="sidebar-menu-block__level-2__item d-flex flex-column menu-item"> <div class="sidebar-menu-block__level-2__item__wrapper "> <a class="sidebar-menu-block__level-2__link" href="/archive/2021-22/department/SS/"> Social Science </a> </div> </li> <li class="sidebar-menu-block__level-2__item d-flex flex-column menu-item"> <div class="sidebar-menu-block__level-2__item__wrapper "> <a class="sidebar-menu-block__level-2__link" href="/archive/2021-22/department/SA/"> Student Activities </a> </div> </li> <li class="sidebar-menu-block__level-2__item d-flex flex-column menu-item"> <div class="sidebar-menu-block__level-2__item__wrapper "> <a class="sidebar-menu-block__level-2__link" href="/archive/2021-22/department/VC/"> Visual Culture </a> </div> </li> <li class="sidebar-menu-block__level-2__item d-flex flex-column menu-item"> <div class="sidebar-menu-block__level-2__item__wrapper "> <a class="sidebar-menu-block__level-2__link" href="/archive/2021-22/department/Wr/"> Writing </a> </div> </li> </ul> </div> </nav> </div> </section> </aside> <div class="left-sidebar-block__content grid-item col-sm-8 pb-5 pb-sm-0 js-sidebar-content"> <div class="course-description2 " id="bibebmb-115"> <div class="course-description2__label"> Bi/BE/BMB 115 </div> <h2 class="course-description2__title"> Viruses and Applications to Biological Systems </h2> <div class="course-description2__units-and-terms"> <span class="course-description2__units-and-terms__item">9 units (3-2-4)</span> | <span class="course-description2__units-and-terms__item">third term</span> </div> <div class="course-description2__description course-description2__general-text"> Learn about viruses as fascinating biological machines, focusing on naturally-occurring and evolved variants, in silico viral vector engineering, and computational methods that include structure visualization and machine learning. This course will introduce the fundamentals in the chemistry and biology of viruses, emphasizing their engineerable properties for use in basic research and translational applications. Topics include: viruses by the numbers, mammalian and non-mammalian (plant, bacteria) viruses, enveloped vs. non-enveloped viruses, host-virus interactions, viral life cycles (replication vs. dormancy), immune responses to viruses, zoonosis, diverse mechanisms of entry and replication, the application of viruses as gene-delivery vehicles (with a focus on adeno-associated viruses or AAVs, lentiviruses, and rabies), and how to engineer viral properties for applications in basic research and gene therapy. The lectures will be complemented by short lab exercises in AAV preparation, bioinformatics and machine learning, and structure visualization. Given in alternate years; offered 2021-22. </div> <div class="course-description2__instructors course-description2__general-text"> <span class="course-description2__instructors__label font-weight-bold">Instructors:</span> Bjorkman, Gradinaru, Van Valen </div> </div> <div class="course-description2 " id="chbmb-129"> <div class="course-description2__label"> Ch/BMB 129 </div> <h2 class="course-description2__title"> Introduction to Biophotonics </h2> <div class="course-description2__units-and-terms"> <span class="course-description2__units-and-terms__item">9 units (3-0-6)</span> | <span class="course-description2__units-and-terms__item">first term</span> </div> <div class="course-description2__prerequisites">Prerequisites: Ch 21 abc and Ch 125 recommended.</div> <div class="course-description2__description course-description2__general-text"> This course will cover basic optics and introduce modern optical spectroscopy principles and microscopy techniques. Topics include molecular spectroscopy, linear and nonlinear florescence microscopy, Raman spectroscopy, coherent microscopy, single-molecule spectroscopy, and super-resolution imaging. </div> <div class="course-description2__instructors course-description2__general-text"> <span class="course-description2__instructors__label font-weight-bold">Instructor:</span> Wei </div> </div> <div class="course-description2 course-description2--not-offered" id="bmbbich-170"> <div class="course-description2__label"> BMB/Bi/Ch 170 </div> <h2 class="course-description2__title"> Biochemistry and Biophysics of Macromolecules and Molecular Assemblies </h2> <div class="course-description2__units-and-terms"> <span class="course-description2__units-and-terms__item">9 units (3- 0-6)</span> | <span class="course-description2__units-and-terms__item">first term</span> </div> <div class="course-description2__prerequisites">Prerequisites: Ch/Bi 110.</div> <div class="course-description2__description course-description2__general-text"> Detailed analysis of the structures of the four classes of biological molecules and the forces that shape them. Introduction to molecular biological and visualization techniques. Not offered 2021-2022. </div> </div> <div class="course-description2 course-description2--not-offered" id="bmbbich-173"> <div class="course-description2__label"> BMB/Bi/Ch 173 </div> <h2 class="course-description2__title"> Biophysical/Structural Methods </h2> <div class="course-description2__units-and-terms"> <span class="course-description2__units-and-terms__item">9 units (3-0-6)</span> | <span class="course-description2__units-and-terms__item">second term</span> </div> <div class="course-description2__description course-description2__general-text"> Basic principles of modern biophysical and structural methods used to interrogate macromolecules from the atomic to cellular levels, including light and electron microscopy, X-ray crystallography, NMR spectroscopy, single molecule techniques, circular dichroism, surface plasmon resonance, mass spectrometry, and molecular dynamics and systems biological simulations. Not offered 2020-21. </div> <div class="course-description2__instructors course-description2__general-text"> <span class="course-description2__instructors__label font-weight-bold">Instructors:</span> Jensen, and other guest lecturers </div> </div> <div class="course-description2 " id="bmbbich-174"> <div class="course-description2__label"> BMB/Bi/Ch 174 </div> <h2 class="course-description2__title"> Advanced Topics in Biochemistry and Molecular Biophysics </h2> <div class="course-description2__units-and-terms"> <span class="course-description2__units-and-terms__item">6 units (3-0-3)</span> | <span class="course-description2__units-and-terms__item">first term</span> </div> <div class="course-description2__prerequisites">Prerequisites: Ch/Bi 110 or equivalent.</div> <div class="course-description2__description course-description2__general-text"> Discussion of research fields in biochemistry and molecular biophysics at Caltech. Development of skills in literature analysis and information synthesis. </div> <div class="course-description2__instructors course-description2__general-text"> <span class="course-description2__instructors__label font-weight-bold">Instructors:</span> Chong, Semlow, and guest lecturers </div> </div> <div class="course-description2 " id="bmbch-178"> <div class="course-description2__label"> BMB/Ch 178 </div> <h2 class="course-description2__title"> Macromolecular Function: kinetics, energetics, and mechanisms </h2> <div class="course-description2__units-and-terms"> <span class="course-description2__units-and-terms__item">9 units (3-0-6)</span> | <span class="course-description2__units-and-terms__item">first term</span> </div> <div class="course-description2__prerequisites">Prerequisites: Ch/Bi 110 or equivalent.</div> <div class="course-description2__description course-description2__general-text"> Discussion of the energetic principles and molecular mechanisms that underlie enzyme's catalytic proficiency and exquisite specificity. Principles of allostery, selectivity, and enzyme evolution. Practical kinetics and their application to more complex biological systems, including steady-state and pre-steadystate kinetics, kinetic simulations, and kinetics at single molecule resolution. </div> <div class="course-description2__instructors course-description2__general-text"> <span class="course-description2__instructors__label font-weight-bold">Instructor:</span> Shan </div> </div> <div class="course-description2 " id="bibmb-189"> <div class="course-description2__label"> Bi/BMB 189 </div> <h2 class="course-description2__title"> The Cell Cycle </h2> <div class="course-description2__units-and-terms"> <span class="course-description2__units-and-terms__item">6 units (2-0-4)</span> | <span class="course-description2__units-and-terms__item">third term</span> </div> <div class="course-description2__prerequisites">Prerequisites: Bi 8 and Bi 9.</div> <div class="course-description2__description course-description2__general-text"> The course covers the mechanisms by which eukaryotic cells control their duplication in a properly regulated manner. A large emphasis will be placed on the controls that cells employ to replicate and segregate their chromosomes with the necessary precision. In addition, the course will examine the mechanisms by which cells detect and rectify damaged DNA throughout the cell cycle. These various processes, collectively known as checkpoint-regulatory mechanisms, lie at the heart of how organisms maintain genomic integrity throughout their lifetimes. These pathways are essential for the prevention of cancer, birth defects, and other maladies. As part of the course, students will give presentations on key publications in the field, including both classic papers and newer papers that employ cutting-edge technologies. </div> <div class="course-description2__instructors course-description2__general-text"> <span class="course-description2__instructors__label font-weight-bold">Instructor:</span> Dunphy </div> </div> <div class="course-description2 " id="bmbch-202-abc"> <div class="course-description2__label"> BMB/Ch 202 abc </div> <h2 class="course-description2__title"> Biochemistry Seminar Course </h2> <div class="course-description2__units-and-terms"> <span class="course-description2__units-and-terms__item">1 unit</span> | <span class="course-description2__units-and-terms__item">first, second, third terms</span> </div> <div class="course-description2__description course-description2__general-text"> The course focuses on a seminar on selected topics from outside faculty on recent advances in biochemistry. Components for each faculty visit include participation in a recitation, a formal discussion section with visiting faculty, and attendance of the Biochemistry seminar. Biochemistry Seminars take place 1-2 times per month (usually 4pm on Thursdays). </div> </div> <div class="course-description2 " id="bibebmb-222"> <div class="course-description2__label"> Bi/BE/BMB 222 </div> <h2 class="course-description2__title"> The Structure of the Cytosol </h2> <div class="course-description2__units-and-terms"> <span class="course-description2__units-and-terms__item">6 units (2-0-4)</span> | <span class="course-description2__units-and-terms__item">third term</span> </div> <div class="course-description2__prerequisites">Prerequisites: Bi 9, Ch/Bi 110-111 or graduate standing in a biological discipline.</div> <div class="course-description2__description course-description2__general-text"> The cytosol, and fluid spaces within the nucleus, were once envisioned as a concentrated soup of proteins, RNA, and small molecules, all diffusing, mixing freely, and interacting randomly. We now know that proteins in the cytosol frequently undergo only restricted diffusion and become concentrated in specialized portions of the cytosol to carry out particular cellular functions. This course consists of lectures, reading, student presentations, and discussion about newly recognized biochemical mechanisms that confer local structure and reaction specificity within the cytosol, including protein scaffolds and "liquid-liquid phase separations" that form "membraneless compartments". </div> <div class="course-description2__instructors course-description2__general-text"> <span class="course-description2__instructors__label font-weight-bold">Instructor:</span> Kennedy </div> </div> <div class="course-description2 " id="bmbch-230"> <div class="course-description2__label"> BMB/Ch 230 </div> <h2 class="course-description2__title"> Macromolecular Structure Determination with Modern X-ray Crystallography Methods </h2> <div class="course-description2__units-and-terms"> <span class="course-description2__units-and-terms__item">12 units (2-4-6)</span> | <span class="course-description2__units-and-terms__item">third term</span> </div> <div class="course-description2__prerequisites">Prerequisites: Consent of instructor.</div> <div class="course-description2__description course-description2__general-text"> Advanced course in macromolecular crystallography integrating lecture and laboratory treatment of diffraction theory, crystallization (proteins, nucleic acids and macromolecular complexes), crystal characterization, X-ray sources and optics, crystal freezing, X-ray diffraction data collection (in-house and synchrotron), data reduction, multiple isomorphous replacement, single- and multi-wavelength anomalous diffraction phasing techniques, molecular replacement, electron density interpretation, structure refinement, structure validation, coordinate deposition and structure presentation. In the laboratory component, one or more proteins will be crystallized and the structure(s) determined by several methods, in parallel with lectures on the theory and discussions of the techniques </div> <div class="course-description2__instructors course-description2__general-text"> <span class="course-description2__instructors__label font-weight-bold">Instructor:</span> Hoelz </div> </div> <div class="course-description2 " id="bibmb-251-abc"> <div class="course-description2__label"> Bi/BMB 251 abc </div> <h2 class="course-description2__title"> Current Research in Cellular and Molecular Biology </h2> <div class="course-description2__units-and-terms"> <span class="course-description2__units-and-terms__item">1 unit</span> <span class="course-description2__units-and-terms__item"></span> </div> <div class="course-description2__prerequisites">Prerequisites: graduate standing.</div> <div class="course-description2__description course-description2__general-text"> Presentations and discussion of research at Caltech in biology and chemistry. Discussions of responsible conduct of research are included. Bi/BMB 251a will not be offered 2021-2022. </div> <div class="course-description2__instructors course-description2__general-text"> <span class="course-description2__instructors__label font-weight-bold">Instructors:</span> Sternberg, Hay </div> </div> <div class="course-description2 course-description2--not-offered" id="bmb-278"> <div class="course-description2__label"> BMB 278 </div> <h2 class="course-description2__title"> Fundamentals of Molecular Genetics </h2> <div class="course-description2__units-and-terms"> <span class="course-description2__units-and-terms__item">9 units (3-0-6)</span> | <span class="course-description2__units-and-terms__item">third term</span> </div> <div class="course-description2__description course-description2__general-text"> Principles and mechanisms of DNA repair and replication, transcription and splicing, and protein synthesis. Not offered 2021-2022. </div> </div> <div class="course-description2 " id="bmb-299"> <div class="course-description2__label"> BMB 299 </div> <h2 class="course-description2__title"> Graduate Research </h2> <div class="course-description2__units-and-terms"> <span class="course-description2__units-and-terms__item">Units to be arranged</span> | <span class="course-description2__units-and-terms__item">first, second, third terms</span> </div> <div class="course-description2__description course-description2__general-text"> Students may register for research units after consultation with their adviser. </div> </div> </div> </div> </div> </div> <div class="page-published-at"> Published Date: July 28, 2022 </div> </main> <footer class="footer-container"> <div class="footer d-flex flex-column flex-wrap flex-sm-row justify-content-sm-between"> <div class="footer__torch-box"></div> <img alt="Caltech Torch" class="footer__torch" src="/static/theme7/img/flame.png"> <div class="footer__left"> <img alt="Caltech Logo" class="footer__left__caltech-wordmark" src="/static/theme7/img/caltech-new-logo.png"> <div class="footer__left__caltech-title">California Institute of Technology</div> </div> <div class="footer__right"> <img class="footer__right__map-marker" src="/static/theme7/img/icon-footerpin.png" alt="map marker"> <div class="footer__right__contact-info-row">1200 East California Boulevard</div> <div class="footer__right__contact-info-row">Pasadena, California 91125</div> </div> <nav class="footer__menu w-100 d-flex flex-wrap justify-content-center" aria-label="Footer"> <a class="footer__menu__link" href="https://www.caltech.edu/privacy-notice">Privacy Notice</a> <span class="footer__menu__link">Site content Copyright @ 2025</span> <a class="footer__menu__link footer__menu__link--login" href="/admin/login/">Log In</a> </nav> </div> </footer> <script src="https://cdn.jsdelivr.net/npm/anchor-js@5.0.0/anchor.min.js" integrity="sha256-aQmOEF2ZD4NM/xt4hthzREIo/2PFkOX/g01WjxEV7Ys=" crossorigin="anonymous"></script> <script> anchors.options = { visible: 'touch', titleText: 'Right-click here and choose "Copy Link" to get a link to this part of the page.', } anchors.add(); </script> </body> </html>