CINXE.COM

<!DOCTYPE html> <html lang="en" dir="ltr"> <head>  <script async src="https://www.googletagmanager.com/gtag/js?id=G-P63WKM1TM1"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-P63WKM1TM1'); </script>  <script type="text/javascript" > (function(m,e,t,r,i,k,a){m[i]=m[i]||function(){(m[i].a=m[i].a||[]).push(arguments)}; m[i].l=1*new Date(); for (var j = 0; j < document.scripts.length; j++) {if (document.scripts[j].src === r) { return; }} k=e.createElement(t),a=e.getElementsByTagName(t)[0],k.async=1,k.src=r,a.parentNode.insertBefore(k,a)}) (window, document, "script", "https://mc.yandex.ru/metrika/tag.js", "ym"); ym(55165297, "init", { clickmap:false, trackLinks:true, accurateTrackBounce:true, webvisor:false }); </script> <noscript><div><img src="https://mc.yandex.ru/watch/55165297" style="position:absolute; left:-9999px;" alt="" /></div></noscript>    <title>Search results for: formulations</title> <meta name="description" content="Search results for: formulations"> <meta name="keywords" content="formulations"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler ml-auto" type="button" data-toggle="collapse" data-target="#navbarMenu" aria-controls="navbarMenu" aria-expanded="false" aria-label="Toggle navigation"> <span class="navbar-toggler-icon"></span> </button> <div class="w-100"> <div class="d-none d-lg-flex flex-row-reverse"> <form method="get" action="https://waset.org/search" class="form-inline my-2 my-lg-0"> <input class="form-control mr-sm-2" type="search" placeholder="Search Conferences" value="formulations" name="q" aria-label="Search"> <button class="btn btn-light my-2 my-sm-0" type="submit"><i class="fas fa-search"></i></button> </form> </div> <div class="collapse navbar-collapse mt-1" id="navbarMenu"> <ul class="navbar-nav ml-auto align-items-center" id="mainNavMenu"> <li class="nav-item"> <a class="nav-link" href="https://waset.org/conferences" title="Conferences in 2024/2025/2026">Conferences</a> </li> <li class="nav-item"> <a class="nav-link" href="https://waset.org/disciplines" title="Disciplines">Disciplines</a> </li> <li class="nav-item"> <a class="nav-link" href="https://waset.org/committees" rel="nofollow">Committees</a> </li> <li class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdownPublications" role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false"> Publications </a> <div class="dropdown-menu" aria-labelledby="navbarDropdownPublications"> <a class="dropdown-item" href="https://publications.waset.org/abstracts">Abstracts</a> <a class="dropdown-item" href="https://publications.waset.org">Periodicals</a> <a class="dropdown-item" href="https://publications.waset.org/archive">Archive</a> </div> </li> <li class="nav-item"> <a class="nav-link" href="https://waset.org/page/support" title="Support">Support</a> </li> </ul> </div> </div> </nav> </div> </header> <main> <div class="container mt-4"> <div class="row"> <div class="col-md-9 mx-auto"> <form method="get" action="https://publications.waset.org/abstracts/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="formulations"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 445</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: formulations</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">445</span> Toxicological Standardization of Heavy Metals and Microbial Contamination Haematinic Herbal Formulations Marketed in India </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=A.%20V.%20Chandewar">A. V. Chandewar</a>, <a href="https://publications.waset.org/abstracts/search?q=Sanjay%20Bais"> Sanjay Bais</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Backgound: In India, drugs of herbal origin have been used in traditional systems of medicines such as Unani and Ayurveda since ancient times. WHO limit for Escherichia coli is 101/gm cfu, for Staphylococus aureus 105/gm cfu, and for Pseudomonas aeruginosa 103/gm cfu and for Salmonella species nil cfu. WHO mentions maximum permissible limits in raw materials only for arsenic, cadmium, and lead, which amount to 1.0, 0.3, and 10 ppm, respectively. Aim: The main purpose of the investigation was to document evidence for the users, and practitioners of marketed haematinic herbal formulations. In the present study haematinic herbal formulations marketed in Yavatmal India were determined for the presence of microbial and heavy metal content. Method: The investigations were performed by using specific medias and atomic absorption spectrometry. Result: The present work indicates the presence of heavy metal contents in herbal formulations selected for study. It was found that arsenic content in formulations was below the permissible limit in all formulations. The cadmium and lead content in six formulations were above the permissible limits. Such formulations are injurious to health of patient if consumed regularly. The specific medias were used to determining the presence of Escherichia coli 4 samples, Staphylococcus aureus 3 samples, and P. aeruginosa 4 samples. The data indicated suggest that there is requirement of in process improvement to provide better quality for consumer health in order to be competitive in international markets. Summary/Conclusion: The presence of microbial and heavy metal content above WHO limits indicates that the GMP was not followed during manufacturing of herbal formulations marketed in India. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=toxicological%20standardization" title="toxicological standardization">toxicological standardization</a>, <a href="https://publications.waset.org/abstracts/search?q=heavy%20metals" title=" heavy metals"> heavy metals</a>, <a href="https://publications.waset.org/abstracts/search?q=microbial%20contamination" title=" microbial contamination"> microbial contamination</a>, <a href="https://publications.waset.org/abstracts/search?q=haematinic%20herbal%20formulations" title=" haematinic herbal formulations"> haematinic herbal formulations</a> </p> <a href="https://publications.waset.org/abstracts/8893/toxicological-standardization-of-heavy-metals-and-microbial-contamination-haematinic-herbal-formulations-marketed-in-india" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/8893.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">449</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">444</span> Preparation and Evaluation of Citrus hystrix Nanoemulsion Formulation against Rice Weevil, Sitophilus oryzae</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Elsayed%20Elmiligy">Elsayed Elmiligy</a>, <a href="https://publications.waset.org/abstracts/search?q=Dzolkhifili%20Omar"> Dzolkhifili Omar</a>, <a href="https://publications.waset.org/abstracts/search?q=Norhayu%20Asib"> Norhayu Asib</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Sitophilus oryzae is a primary destructive insect pest. A study on nanoemulsion formulation of C. hystrix peel oil and evaluation of its insecticidal effect on the adults of S. oryzae was held in toxicology laboratory at Faculty of Agriculture, Universiti Putra Malaysia (UPM). Three nanoemulsion formulations (F1, F2, and F3) were prepared using C. hystrix peel oil (a.i), Tween 80 (surfactant), AMD 810 (carrier) and deionized water. The selected formulations have undergone stability tests, surface tension, zeta potential and particle size measurements. The formulations were tested for their contact and fumigant activity against the adults of S. oryzae. LC₅₀ values were obtained from Probit regressions using the Polo-PC program. All the formulations showed stability under storage temperature and centrifugation. They were characterized as nanoemulsions as they remained in the range of nanoscale 200 nm. The formulations revealed lower surface tension in the range of 29.5 to 30.4 mN/m. They showed stable of zeta potential values. The formulations showed the highest toxicity against the adults of S. oryzae. The order of decreasing toxicity was F1 > F2 > F3 with LC₅₀ values of 52.1, 58.5, and 61.7 µl/l for contact toxicity, and 71, 75.5, and 76.7 µl/l air for fumigant bioassay after 72 hours. Formulation of C. hystrix peel oil in a nanoemulsion enhance its effectiveness and reduce the amount of applied essential oil. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Citrus%20hystrix%20peel%20oil" title="Citrus hystrix peel oil">Citrus hystrix peel oil</a>, <a href="https://publications.waset.org/abstracts/search?q=Sitophilus%20oryzae" title=" Sitophilus oryzae"> Sitophilus oryzae</a>, <a href="https://publications.waset.org/abstracts/search?q=nanoemulsion" title=" nanoemulsion"> nanoemulsion</a>, <a href="https://publications.waset.org/abstracts/search?q=contact%20toxicity" title=" contact toxicity"> contact toxicity</a>, <a href="https://publications.waset.org/abstracts/search?q=Fumigant%20bioassay" title=" Fumigant bioassay"> Fumigant bioassay</a> </p> <a href="https://publications.waset.org/abstracts/98408/preparation-and-evaluation-of-citrus-hystrix-nanoemulsion-formulation-against-rice-weevil-sitophilus-oryzae" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/98408.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">140</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">443</span> A Brief History of Kampo Extract Formulations for Prescription in Japan</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Kazunari%20Ozaki">Kazunari Ozaki</a>, <a href="https://publications.waset.org/abstracts/search?q=Mitsuru%20Kageyama"> Mitsuru Kageyama</a>, <a href="https://publications.waset.org/abstracts/search?q=Kenki%20Miyazawa"> Kenki Miyazawa</a>, <a href="https://publications.waset.org/abstracts/search?q=Yoshio%20Nakamura"> Yoshio Nakamura</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Kampo (Japanese Traditional medicine) is a medicine traditionally practiced in Japan, based on ancient Chinese medicine. Most Kampo doctors have used decoction of crude drug pieces for treatment. 93% of the Kampo drugs sold in Japan are Kampo products nowadays. Of all Kampo products, 81% of them are Kampo extract formulations for prescription, which is prepared in powdered or granulated form from medicinal crude drug extracts mixed with appropriate excipient. Physicians with medical license for Western medicine prescribe these Kampo extract formulations for prescription in Japan. Objectives: Our study aims at presenting a brief history of Kampo extract formulations for prescription in Japan. Methods: Systematic searches for relevant studies were conducted using not only printed journals but also electronic journals from the bibliographic databases, such as PubMed/Medline, Ichushi-Web, and university/institutional websites, as well as search engines, such as Google and Google Scholar. Results: The first commercialization of Kampo extract formulations for general use (or OTC (over-the-counter) Kampo extract formulation) was achieved after 1957. The number of drugs has been subsequentially increased, reaching 148 Kampo extract formulation for prescription currently. Conclusion: We provide a history of Kampo extract formulations for prescription in Japan. The originality of this research is that it analyzes the background history of Kampo in parallel with relevant transitions in the government and insurance systems. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=health%20insurance%20system" title="health insurance system">health insurance system</a>, <a href="https://publications.waset.org/abstracts/search?q=history" title=" history"> history</a>, <a href="https://publications.waset.org/abstracts/search?q=Kampo" title=" Kampo"> Kampo</a>, <a href="https://publications.waset.org/abstracts/search?q=Kampo%20extract%20formulation%20for%20prescription" title=" Kampo extract formulation for prescription"> Kampo extract formulation for prescription</a>, <a href="https://publications.waset.org/abstracts/search?q=OTC%20Kampo%20extract%20formulation" title=" OTC Kampo extract formulation"> OTC Kampo extract formulation</a>, <a href="https://publications.waset.org/abstracts/search?q=pattern%20corresponding%20prescription%20%28Ho-sho-so-tai%29%20system" title=" pattern corresponding prescription (Ho-sho-so-tai) system"> pattern corresponding prescription (Ho-sho-so-tai) system</a> </p> <a href="https://publications.waset.org/abstracts/81559/a-brief-history-of-kampo-extract-formulations-for-prescription-in-japan" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/81559.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">286</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">442</span> Increasing Solubility and Bioavailability of Fluvastatin through Transdermal Nanoemulsion Gel Delivery System for the Treatment of Osteoporosis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ramandeep%20Kaur">Ramandeep Kaur</a>, <a href="https://publications.waset.org/abstracts/search?q=Makula%20Ajitha"> Makula Ajitha</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Fluvastatin has been reported for increasing bone mineral density in osteoporosis since last decade. Systemically administered drug undergoes extensive hepatic first-pass metabolism, thus very small amount of drug reaches the bone tissue which is highly insignificant. The present study aims to deliver fluvastatin in the form of nanoemulsion (NE) gel directly to the bone tissue through transdermal route thereby bypassing hepatic first pass metabolism. The NE formulation consisted of isopropyl myristate as oil, tween 80 as surfactant, transcutol as co-surfactant and water as the aqueous phase. Pseudoternary phase diagrams were constructed using aqueous titration method and NE’s obtained were subjected to thermodynamic-kinetic stability studies. The stable NE formulations were evaluated for their droplet size, zeta potential, and transmission electron microscopy (TEM). The nano-sized formulations were incorporated into 0.5% carbopol 934 gel matrix. Ex-vivo permeation behaviour of selected formulations through rat skin was investigated and compared with the conventional formulations (suspension and emulsion). Further, in-vivo pharmacokinetic study was carried using male Wistar rats. The optimized NE formulations mean droplet size was 11.66±3.2 nm with polydispersity index of 0.117. Permeation flux of NE gel formulations was found significantly higher than the conventional formulations i.e. suspension and emulsion. In vivo pharmacokinetic study showed significant increase in bioavailability (1.25 fold) of fluvastatin than oral formulation. Thus, it can be concluded that NE gel was successfully developed for transdermal delivery of fluvastatin for the treatment of osteoporosis. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=fluvastatin" title="fluvastatin">fluvastatin</a>, <a href="https://publications.waset.org/abstracts/search?q=nanoemulsion%20gel" title=" nanoemulsion gel"> nanoemulsion gel</a>, <a href="https://publications.waset.org/abstracts/search?q=osteoporosis" title=" osteoporosis"> osteoporosis</a>, <a href="https://publications.waset.org/abstracts/search?q=transdermal" title=" transdermal"> transdermal</a> </p> <a href="https://publications.waset.org/abstracts/75669/increasing-solubility-and-bioavailability-of-fluvastatin-through-transdermal-nanoemulsion-gel-delivery-system-for-the-treatment-of-osteoporosis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/75669.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">189</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">441</span> Insecticidal Effects of the Wettable Powder Formulations of Plant Extracts on Cotton Bollworm, Helicoverpa armigera (Lep. Noctuidae)</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Reza%20Sadeghi">Reza Sadeghi</a>, <a href="https://publications.waset.org/abstracts/search?q=Maryam%20Nazarahari"> Maryam Nazarahari</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Due to the numerous side effects of chemical pesticides, in this research, to provide the practical use of herbal compounds, the extracts of the two plants of thyme and eucalyptus were extracted by using water, 70% ethanol, and n-hexane solvents via percolation method and then formulated as wettable powders. The mortality rates of cotton bollworm (Helicoverpa armigera) were investigated under different concentrations of ethanolic, hexanic, and aqueous extracts of thyme and eucalyptus and their formulations in laboratory conditions. The results showed that the used concentrations, types of solvents, and sorts of formulations significantly affected the mortality rates of cotton bollworm larvae during the exposure period of 24 h. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cotton%20bollworm" title="cotton bollworm">cotton bollworm</a>, <a href="https://publications.waset.org/abstracts/search?q=eucalyptus" title=" eucalyptus"> eucalyptus</a>, <a href="https://publications.waset.org/abstracts/search?q=formulation" title=" formulation"> formulation</a>, <a href="https://publications.waset.org/abstracts/search?q=thyme" title=" thyme"> thyme</a>, <a href="https://publications.waset.org/abstracts/search?q=toxicity" title=" toxicity"> toxicity</a> </p> <a href="https://publications.waset.org/abstracts/173002/insecticidal-effects-of-the-wettable-powder-formulations-of-plant-extracts-on-cotton-bollworm-helicoverpa-armigera-lep-noctuidae" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/173002.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">85</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">440</span> Evaluation of Trapping Efficiency of Slow Released Formulations of Methyl Eugenol with Lanolin Wax against Bactrocera zonata</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Waleed%20Afzal%20Naveed">Waleed Afzal Naveed</a>, <a href="https://publications.waset.org/abstracts/search?q=Muhammd%20Dildar%20Gogi"> Muhammd Dildar Gogi</a>, <a href="https://publications.waset.org/abstracts/search?q=Muhammad%20Sufian"> Muhammad Sufian</a>, <a href="https://publications.waset.org/abstracts/search?q=Muhammad%20Amjad%20Ali"> Muhammad Amjad Ali</a>, <a href="https://publications.waset.org/abstracts/search?q=Muhammad%20Junaid%20Nisar"> Muhammad Junaid Nisar</a>, <a href="https://publications.waset.org/abstracts/search?q=Mubashar%20Iqbal"> Mubashar Iqbal</a>, <a href="https://publications.waset.org/abstracts/search?q=Amna%20Jalal"> Amna Jalal</a>, <a href="https://publications.waset.org/abstracts/search?q=Faisal%20Munir"> Faisal Munir</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The study was carried out to evaluate the performance of Slow-Released Formulations (SRF) of Methyl eugenol with Lanolin wax in orchard of the University of Agriculture Faisalabad, Pakistan against fruit flies. Lanolin wax was mixed with methyl eugenol in nine ratios (10:90, 20:80, 30:70, 40:60, 50:50, 60:40, 70:30, 80:20 and 90:10). The results revealed that SRFₗₗ-7 trapped 42.1 flies /day/trap, exhibited an attractancy index (AI) of 51.71%, proved strongly attractive SRFₗₗ for B. zonata and was categorized as Class-III slow-released formulation (AI > 50%). The SRFₗₗ-2, SRFₗₗ-3, SRFₗₗ-4, SRFₗₗ-5, SRFₗₗ-6, SRFₗₗ-8 and SRFₗₗ-9 trapped 17.7, 27.9, 32.3, 23.8, 28.3, 37.8 and 19.9 flies /day/trap, exhibited an attractancy index (AI) of 20.54%, 41.02%, 26.00%, 34.15%, 43.50%, 49.86% and 46.07% AI respectively, proved moderately attractive slow-released formulations for B. zonata and were categorized as Class-II slow-released formulations (AI = 11-50%). However, SRFₗₗ-1 trapped 14.8 flies /day/trap, exhibited 0.71% AI proved little or nonattractive slow-released formulation and was categorized as Class-I slow-released formulation for B. zonata (AI < 11%). <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Bactrocera%20zonata" title="Bactrocera zonata">Bactrocera zonata</a>, <a href="https://publications.waset.org/abstracts/search?q=slow-released%20formulation" title=" slow-released formulation"> slow-released formulation</a>, <a href="https://publications.waset.org/abstracts/search?q=lenoline%20wax" title=" lenoline wax"> lenoline wax</a>, <a href="https://publications.waset.org/abstracts/search?q=methyl%20euginol" title=" methyl euginol"> methyl euginol</a> </p> <a href="https://publications.waset.org/abstracts/97291/evaluation-of-trapping-efficiency-of-slow-released-formulations-of-methyl-eugenol-with-lanolin-wax-against-bactrocera-zonata" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/97291.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">237</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">439</span> Systematic Formulation Development and Evaluation of Self-Nanoemulsifying Systems of Rosuvastatin Employing QbD Approach and Chemometric Techniques</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sarwar%20Beg">Sarwar Beg</a>, <a href="https://publications.waset.org/abstracts/search?q=Gajanand%20Sharma"> Gajanand Sharma</a>, <a href="https://publications.waset.org/abstracts/search?q=O.%20P.%20Katare"> O. P. Katare</a>, <a href="https://publications.waset.org/abstracts/search?q=Bhupinder%20Singh"> Bhupinder Singh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The current studies entail development of self-nano emulsifying drug delivery systems (SNEDDS) of rosuvastatin, employing rational QbD-based approach for enhancing its oral bioavailability. SNEDDS were prepared using the blend of lipidic and emulsifying excipients, i.e., Peceol, Tween 80, and Transcutol HP. The prepared formulations evaluated for in vitro drug release, ex vivo permeation, in situ perfusion studies and in vivo pharmacokinetic studies in rats, which demonstrated 3-4 fold improvement in biopharmaceutical performance of the developed formulations. Cytotoxicity studies using MTT assay and histopathological studies in intestinal cells revealed the lack of cytotoxicity and thereby safety and efficacy of the developed formulations. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=SNEDDS" title="SNEDDS">SNEDDS</a>, <a href="https://publications.waset.org/abstracts/search?q=bioavailability" title=" bioavailability"> bioavailability</a>, <a href="https://publications.waset.org/abstracts/search?q=solubility" title=" solubility"> solubility</a>, <a href="https://publications.waset.org/abstracts/search?q=Quality%20by%20Design%20%28QbD%29" title=" Quality by Design (QbD)"> Quality by Design (QbD)</a> </p> <a href="https://publications.waset.org/abstracts/13541/systematic-formulation-development-and-evaluation-of-self-nanoemulsifying-systems-of-rosuvastatin-employing-qbd-approach-and-chemometric-techniques" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/13541.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">505</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">438</span> Carbonation and Mechanical Performance of Reactive Magnesia Based Formulations</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Cise%20Unluer">Cise Unluer</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Reactive MgO hydrates to form brucite (Mg(OH)2, magnesium hydroxide), which can then react with CO2 and additional water to form a range of strength providing hydrated magnesium carbonates (HMCs) within cement-based formulations. The presented work focuses on the use of reactive MgO in a range of concrete mixes, where it carbonates by absorbing CO2 and gains strength accordingly. The main goal involves maximizing the amount of CO2 absorbed within construction products, thereby reducing the overall environmental impact of the designed formulations. Microstructural analyses including scanning electron microscopy (SEM), X-ray diffraction (XRD) and thermogravimetry/differential thermal analysis (TG/DTA) are used in addition to porosity, permeability and unconfined compressive strength (UCS) testing to understand the performance mechanisms. XRD Reference Intensity Ratio (RIR), acid digestion and TG/DTA are utilized to quantify the amount of CO2 sequestered, with the goal of achieving 100% carbonation through careful mix design, leading to a range of carbon neutral products with high strengths. As a result, samples stronger than those containing Portland cement (PC) were produced, revealing the link between the mechanical performance and microstructural development of the developed formulations with the amount of CO2 sequestered. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=carbonation" title="carbonation">carbonation</a>, <a href="https://publications.waset.org/abstracts/search?q=compressive%20strength" title=" compressive strength"> compressive strength</a>, <a href="https://publications.waset.org/abstracts/search?q=reactive%20MgO%20cement" title=" reactive MgO cement"> reactive MgO cement</a>, <a href="https://publications.waset.org/abstracts/search?q=sustainability" title=" sustainability"> sustainability</a> </p> <a href="https://publications.waset.org/abstracts/62022/carbonation-and-mechanical-performance-of-reactive-magnesia-based-formulations" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/62022.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">180</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">437</span> Study on Preparation and Storage of Composite Vegetable Squash of Tomato, Pumpkin and Ginger</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=K.%20Premakumar">K. Premakumar</a>, <a href="https://publications.waset.org/abstracts/search?q=R.%20G.%20Lakmali"> R. G. Lakmali</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20M.%20A.%20C.%20U.%20Senarathna"> S. M. A. C. U. Senarathna </a> </p> <p class="card-text"><strong>Abstract:</strong></p> In the present world, production and consumption of fruit and vegetable beverages have increased owing to the healthy life style of the people. Therefore, a study was conducted to develop composite vegetable squash by incorporating nutritional, medicinal and organoleptic properties of tomato, pumpkin and ginger. Considering the finding of several preliminary studies, five formulations in different combinations tomato pumpkin were taken and their physico-chemical parameters such as pH, TSS, titrable acidity, ascorbic acid content and total sugar and organoleptic parameters such as colour, aroma, taste, nature, overall acceptability were analyzed. Then the best sample was improved by using 1 % ginger (50% tomato+ 50% pumpkin+ 1% ginger). Best three formulations were selected for storage studied. The formulations were stored at 30 °C room temperature and 70-75% of RH for 12 weeks. Physicochemical parameters , organoleptic and microbial activity (total plate count, yeast and mold, E-coil) were analyzed during storage periods and protein content, fat content, ash were also analysed%.The study on the comparison of physico-chemical and sensory qualities of stored Squashes was done up to 12 weeks storage periods. The nutritional analysis of freshly prepared tomato pumpkin vegetable squash formulations showed increasing trend in titratable acidity, pH, total sugar, non -reducing sugar, total soluble solids and decreasing trend in ascorbic acid and reducing sugar with storage periods. The results of chemical analysis showed that, there were the significant different difference (p < 0.05) between tested formulations. Also, sensory analysis also showed that there were significant differences (p < 0.05) for organoleptic character characters between squash formulations. The highest overall acceptability was observed in formulation with 50% tomato+ 50% pumpkin+1% ginger and all the all the formulations were microbiologically safe for consumption. Based on the result of physico-chemical characteristics, sensory attributes and microbial test, the Composite Vegetable squash with 50% tomato+50% pumpkin+1% ginger was selected as best formulation and could be stored for 12 weeks without any significant changes in quality characteristics. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=nutritional%20analysis" title="nutritional analysis">nutritional analysis</a>, <a href="https://publications.waset.org/abstracts/search?q=formulations" title=" formulations"> formulations</a>, <a href="https://publications.waset.org/abstracts/search?q=sensory%20attributes" title=" sensory attributes"> sensory attributes</a>, <a href="https://publications.waset.org/abstracts/search?q=squash" title=" squash"> squash</a> </p> <a href="https://publications.waset.org/abstracts/59602/study-on-preparation-and-storage-of-composite-vegetable-squash-of-tomato-pumpkin-and-ginger" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/59602.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">199</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">436</span> Improving Lutein Bioavailability by Nanotechnology Applications</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hulya%20Ilyasoglu%20Buyukkestelli">Hulya Ilyasoglu Buyukkestelli</a>, <a href="https://publications.waset.org/abstracts/search?q=Sedef%20Nehir%20El"> Sedef Nehir El</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Lutein is a member of xanthophyll group of carotenoids found in fruits and vegetables. Lutein accumulates in the macula region of the retina and known as macular pigment which absorbs damaging light in the blue wavelengths. The presence of lutein in retina has been related to decreased risk of two common eye diseases, age-related macular degeneration, and cataract. Being a strong antioxidant, it may also have effects on prevention some types of cancer, cardiovascular disease, cognitive dysfunction. Humans are not capable of synthesizing lutein de novo; therefore it must be provided naturally by the diet, fortified foods, and beverages or nutritional supplement. However, poor bioavailability and physicochemical stability limit its usage in the food industry. Poor solubility in digestive fluids and sensitivity to heat, light, and oxygen are both affect the stability and bioavailability of lutein. In this context, new technologies, delivery systems and formulations have been applied to improve stability and solubility of lutein. Nanotechnology, including nanoemulsion, nanocrystal, nanoencapsulation technology and microencapsulation by complex coacervation, spray drying are promising ways of increasing solubilization of lutein and stability of it in different conditions. Bioavailability of lutein is also dependent on formulations used, starch formulations and milk proteins, especially sodium caseinate are found effective in improving the bioavailability of lutein. Designing foods with highly bioavailable and stabile lutein needs knowledge about current technologies, formulations, and further needs. This review provides an overview of the new technologies and formulations used to improve bioavailability of lutein and also gives a future outlook to food researches. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=bioavailability" title="bioavailability">bioavailability</a>, <a href="https://publications.waset.org/abstracts/search?q=formulation" title=" formulation"> formulation</a>, <a href="https://publications.waset.org/abstracts/search?q=lutein" title=" lutein"> lutein</a>, <a href="https://publications.waset.org/abstracts/search?q=nanotechnology" title=" nanotechnology"> nanotechnology</a> </p> <a href="https://publications.waset.org/abstracts/81492/improving-lutein-bioavailability-by-nanotechnology-applications" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/81492.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">380</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">435</span> Performance of Different Biodegradable Waxes Based Specialized Pheromone and Lure Application Technology-Male Anhelation Technique-Cue Lure Formulations in Bittergourd Field against Bactrocera cucurbitae</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Amna%20Jalal">Amna Jalal</a>, <a href="https://publications.waset.org/abstracts/search?q=Muhammad%20Dildar%20Gogi"> Muhammad Dildar Gogi</a>, <a href="https://publications.waset.org/abstracts/search?q=Muhammad%20Jalal%20Arif"> Muhammad Jalal Arif</a>, <a href="https://publications.waset.org/abstracts/search?q=Anum%20Tariq"> Anum Tariq</a>, <a href="https://publications.waset.org/abstracts/search?q=Waleed%20Afzal%20Naveed"> Waleed Afzal Naveed</a>, <a href="https://publications.waset.org/abstracts/search?q=Talha%20Farooq"> Talha Farooq</a>, <a href="https://publications.waset.org/abstracts/search?q=Mubashir%20Iqbal"> Mubashir Iqbal</a>, <a href="https://publications.waset.org/abstracts/search?q=Muhammad%20Junaid%20Nisar"> Muhammad Junaid Nisar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Melon fruit flies (Diptera: Tephritidae: Dacinae) are economically important pests of the cucurbits and are geographically distributed throughout the tropics and subtropics of the world. It causes heavy quantitative and qualitative losses in bitter gourd. The present experiment was carried out to evaluate the performance of different biodegradable waxes based SPLAT-MAT-CL (Specialized Pheromone and Lure Application Technology-Male Anhelation Technique- Cue Lure) formulations in bitter gourd field. Fourteen SPLAT-MAT emulsions/formulations were prepared by admixing different SPLAT matrices with toxicant (spinosad) and sex pheromone cuelure (attractant) in different proportionate percentage by weight. The results revealed that attraction and trapping of fruit flies of B. cucurbitae varied significantly for different SPLAT-MAT-CL formulations (p < 0.05). The maximum B. cucurbitae males were trapped in SPLAT-MAT-CL-7 (60 flies/trap/day) followed by SPLAT-MAT-CL-9 (40 flies/trap/day). The performance of all other formulations of SPLAT-MAT-CL was found in the order of SPLAT-MAT-CL-8 (30 flies/trap/day) > SPLAT-MAT-CL-3 (28 flies/trap/day) > SPLAT-MAT-CL-5 (25 flies/trap/day) > SPLAT-MAT-CL-4 (22 flies/trap/day) > SPLAT-MAT-CL-12 (20 flies/trap/day) SPLAT-MAT-CL-2 (19 flies/trap/day) > SPLAT-MAT-CL-14 (17 flies/trap/day) > SPLAT-MAT-CL-13 (15 flies/trap/day) > SPLAT-MAT-CL-11 (10 flies/trap/day) > SPLAT-MAT-CL-1 (8 flies/trap/day) > SPLAT-MAT-CL-10 (02 flies/trap/day). Overall, all the SPLAT-MAT-CL formulations, except SPLAT-MAT-CL-10, demonstrated higher density of captures of B. cucurbitae males as compared to standard (06 flies/trap/day). The results also demonstrate that SPLAT-MAT-CL-7, SPLAT-MAT-CL-9, SPLAT-MAT-CL-8, SPLAT-MAT-CL-3, SPLAT-MAT-CL-5, SPLAT-MAT-CL-4, SPLAT-MAT-CL-12, SPLAT-MAT-CL-2, SPLAT-MAT-CL-14, SPLAT-MAT-CL-13, SPLAT-MAT-CL-11 and SPLAT-MAT-CL-1 explained approximately 5, 4.6, 4.1, 3.6, 3.3, 3.1,2.8,2.5 and 1.6 times higher captures of B. cucurbitae males over standards. However, SPLAT-MAT-CL-10 demonstrated 3 times fewer captures of B. cucurbitae males over standards. In conclusion, SPLAT-MAT-CL-7, SPLAT-MAT-CL-9 can be exploited for the monitoring and trapping of B. cucurbitae in its IPM of program. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=attractancy" title="attractancy">attractancy</a>, <a href="https://publications.waset.org/abstracts/search?q=field%20conditions" title=" field conditions"> field conditions</a>, <a href="https://publications.waset.org/abstracts/search?q=melon%20fruit%20fly" title=" melon fruit fly"> melon fruit fly</a>, <a href="https://publications.waset.org/abstracts/search?q=SPLAT-MAT-CL" title=" SPLAT-MAT-CL"> SPLAT-MAT-CL</a> </p> <a href="https://publications.waset.org/abstracts/97310/performance-of-different-biodegradable-waxes-based-specialized-pheromone-and-lure-application-technology-male-anhelation-technique-cue-lure-formulations-in-bittergourd-field-against-bactrocera-cucurbitae" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/97310.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">268</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">434</span> Sun Protection Factor (SPF) Determination of Sericin Cream and Niosomal Gel</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Farzad%20Doostishoar">Farzad Doostishoar</a>, <a href="https://publications.waset.org/abstracts/search?q=Abbas%20Pardakhty"> Abbas Pardakhty</a>, <a href="https://publications.waset.org/abstracts/search?q=Abdolreza%20Hassanzadeh"> Abdolreza Hassanzadeh</a>, <a href="https://publications.waset.org/abstracts/search?q=Sudeh%20salarpour"> Sudeh salarpour</a>, <a href="https://publications.waset.org/abstracts/search?q=Elham%20Sharif"> Elham Sharif</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Sericin is a protein extracted from silk and has antioxidant, antimicrobial, antineoplastic, wound healing and moisturizing properties. Different cosmetic formulation of sericin is available in different countries such as Japan and the other south-eastern Asian countries. We formulated and evaluated the sunscreen properties of topical formulations of sericin by an in vitro method. Method: Niosomes composed of sorbitan palmitate (Span 40), polysorbate 40 (Tween 40) and cholesterol (300 µmol, 3.5:3.5:3 molar ratio) were prepared by film hydration technique. Sericin was dissolved in normal saline and the lipid hydration was carried out at 60°C and the niosomes were incorporated in a Carbomer gel base. A W/O cream was also prepared and the release of sericin was evaluated by using Franz diffusion cell. Particle size analysis, sericin encapsulation efficiency measurement, morphological studies and stability evaluation were done in niosomal formulations. SPF was calculated by using Transpore tape in vitro method for both formulations. Results: Niosomes had high stability during 6 months storage at 4-8°C. The mean volume diameter of niosomes was less than 7 µm which is ideal for sustained release of drugs in topical formulations. The SPF of niosomal gel was 25 and higher than sericin cream with a diffusion based release pattern of active material. Conclusion: Sericin can be successfully entrapped in niosomes with sustained release pattern and relatively high SPF. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=sericin" title="sericin">sericin</a>, <a href="https://publications.waset.org/abstracts/search?q=niosomes" title=" niosomes"> niosomes</a>, <a href="https://publications.waset.org/abstracts/search?q=sun%20protection%20factor" title=" sun protection factor"> sun protection factor</a>, <a href="https://publications.waset.org/abstracts/search?q=cream" title=" cream"> cream</a>, <a href="https://publications.waset.org/abstracts/search?q=gel" title=" gel"> gel</a> </p> <a href="https://publications.waset.org/abstracts/25326/sun-protection-factor-spf-determination-of-sericin-cream-and-niosomal-gel" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/25326.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">500</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">433</span> Design and Development of Mucoadhesive Buccal Film Bearing Itraconazole</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Yuvraj%20Singh%20Dangi">Yuvraj Singh Dangi</a>, <a href="https://publications.waset.org/abstracts/search?q=Kamta%20Prasad%20Namdeo"> Kamta Prasad Namdeo</a>, <a href="https://publications.waset.org/abstracts/search?q=Surendra%20Bodhake"> Surendra Bodhake</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The purpose of this research was to develop and evaluate mucoadhesive films for buccal administration of itraconazole using film-forming and mucoashesive polymers. Buccal films of chitosan bearing Itraconazole were prepared by solvent casting technique. The films have been evaluated in terms of film weight, thickness, density, surface pH, FTIR, X-ray diffraction analysis, bioadhesion, swelling properties, and in vitro drug release studies. It was found that film formulations of 2 cm2 size having weight in the range of 204 ± 0.76 to 223 ± 2.09 mg and film thickness were in the range of 0.44 ± 0.11 to 0.57 ± 0.19 mm. Density of the films was found to be 0.102 to 0.126 g/ml. Drug content was found to be uniform in the range of 8.23 ± 0.07 to 8.73 ± 0.09 mg/cm2 for formulation A1 to A4. Maximum bioadhesion force was recorded for HPMC buccal films (A2) i.e. 0.57 ± 0.47 as compared to other films. In vitro residence time was in range of 1.7 ± 0.12 to 7.65 ± 0.15 h. The drug release studies show that formulations follow non-fickian diffusion. These mucoadhesive formulations could offer many advantages in comparison to traditional treatments. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=biovariability" title="biovariability">biovariability</a>, <a href="https://publications.waset.org/abstracts/search?q=buccal%20patches" title=" buccal patches"> buccal patches</a>, <a href="https://publications.waset.org/abstracts/search?q=itraconazole" title=" itraconazole"> itraconazole</a>, <a href="https://publications.waset.org/abstracts/search?q=Mucoadhesion" title=" Mucoadhesion"> Mucoadhesion</a> </p> <a href="https://publications.waset.org/abstracts/24059/design-and-development-of-mucoadhesive-buccal-film-bearing-itraconazole" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/24059.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">513</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">432</span> Study of the Potential of Raw Sediments and Sediments Treated with Lime or Cement for Use in a Foundation Layer and the Base Layer of a Roadway </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Nor-Edine%20Abriak">Nor-Edine Abriak</a>, <a href="https://publications.waset.org/abstracts/search?q=Mahfoud%20Benzerzour"> Mahfoud Benzerzour</a>, <a href="https://publications.waset.org/abstracts/search?q=Mouhamadou%20Amar"> Mouhamadou Amar</a>, <a href="https://publications.waset.org/abstracts/search?q=Abdeljalil%20Zri"> Abdeljalil Zri</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this work, firstly we have studied the potential of raw sediments and sediments treated with lime or cement for use in a foundation layer and the base layer of a roadway. Secondly, we have examined mineral changes caused by the addition of lime or cement in order to explain the mechanical performance of stabilized sediments. After determining the amount of lime and cement required stabilizing the sediments, the compaction characteristics and Immediate Bearing Capacity (IBI) were studied using the Modified Proctor method. Then, the evolution of the three parameters, which are optimum water content, maximum dry density and IBI, were determined. Mechanical performances can be evaluated through resistance to compression, resistance under traction and the elasticity modulus. The resistances of the formulations treated with ROLAC®645 increase with the amount of ROLAC®645. Traction resistance and the elastic modulus were used to evaluate the potential of the formulations as road construction materials using the classification diagram. The results show that all the other formulations with ROLAC®645 can be used in subgrades and foundation layers for roads. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=sediment" title="sediment">sediment</a>, <a href="https://publications.waset.org/abstracts/search?q=lime" title=" lime"> lime</a>, <a href="https://publications.waset.org/abstracts/search?q=cement" title=" cement"> cement</a>, <a href="https://publications.waset.org/abstracts/search?q=roadway" title=" roadway"> roadway</a> </p> <a href="https://publications.waset.org/abstracts/53905/study-of-the-potential-of-raw-sediments-and-sediments-treated-with-lime-or-cement-for-use-in-a-foundation-layer-and-the-base-layer-of-a-roadway" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/53905.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">267</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">431</span> Rapid Nanoparticle Formulation Development and Screening Using NanoFabTxTM Platform</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Zhen%20Ye">Zhen Ye</a>, <a href="https://publications.waset.org/abstracts/search?q=Maryam%20Zaroudi"> Maryam Zaroudi</a>, <a href="https://publications.waset.org/abstracts/search?q=Elizabeth%20Aisenbrey"> Elizabeth Aisenbrey</a>, <a href="https://publications.waset.org/abstracts/search?q=Nicolynn%20E.%20Davis"> Nicolynn E. Davis</a>, <a href="https://publications.waset.org/abstracts/search?q=Peng%20Gao"> Peng Gao</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Nanoparticles have been used as drug delivery systems in the treatment of life-threatening diseases for decades, but traditional formulation development methods are time consuming and labor intensive. Millipore Sigma has developed a platform¬¬– NanoFabTxTM¬¬– for rapid and reproducible formulation development and screening to ensure consistentnanoparticle characteristics. Reproducible and precise control of the development process for a range of nanoparticle formulations accelerates the introduction of novel formulations to the clinic. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Bio%20platform" title="Bio platform">Bio platform</a>, <a href="https://publications.waset.org/abstracts/search?q=Formulation%20development" title=" Formulation development"> Formulation development</a>, <a href="https://publications.waset.org/abstracts/search?q=NanoFabTxTM" title=" NanoFabTxTM"> NanoFabTxTM</a>, <a href="https://publications.waset.org/abstracts/search?q=Drug%20delivery" title=" Drug delivery"> Drug delivery</a> </p> <a href="https://publications.waset.org/abstracts/154392/rapid-nanoparticle-formulation-development-and-screening-using-nanofabtxtm-platform" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/154392.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">236</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">430</span> Nano-Pesticides: Recent Emerging Tool for Sustainable Agricultural Practices</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ekta">Ekta</a>, <a href="https://publications.waset.org/abstracts/search?q=G.%20K.%20Darbha"> G. K. Darbha</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Nanotechnology offers the potential of simultaneously increasing efficiency as compared to their bulk material as well as reducing harmful environmental impacts of pesticides in field of agriculture. The term nanopesticide covers different pesticides that are cumulative of several surfactants, polymers, metal ions, etc. of nanometer size ranges from 1-1000 nm and exhibit abnormal behavior (high efficacy and high specific surface area) of nanomaterials. Commercial formulations of pesticides used by farmers nowadays cannot be used effectively due to a number of problems associated with them. For example, more than 90% of applied formulations are either lost in the environment or unable to reach the target area required for eﬀective pest control. Around 20−30% of pesticides are lost through emissions. A number of factors (application methods, physicochemical properties of the formulations, and environmental conditions) can inﬂuence the extent of loss during application. It is known that among various formulations, polymer-based formulations show the greatest potential due to their greater efficacy, slow release and protection against premature degradation of active ingredient as compared to other commercial formulations. However, the nanoformulations can have a significant effect on the fate of active ingredient as well as may release some new ingredients by reacting with existing soil contaminants. Environmental fate of these newly generated species is still not explored very well which is essential to field scale experiments and hence a lot to be explored in the field of environmental fate, nanotoxicology, transport properties and stability of such formulations. In our preliminary work, we have synthesized polymer based nanoformulation of commercially used weedicide atrazine. Atrazine belongs to triazine class of herbicide, which is used in the effective control of seed germinated dicot weeds and grasses. It functions by binding to the plastoquinone-binding protein in PS-II. Plant death results from starvation and oxidative damage caused by breakdown in electron transport system. The stability of the suspension of nanoformulation containing herbicide has been evaluated by considering different parameters like polydispersity index, particle diameter, zeta-potential under different environmental relevance condition such as pH range 4-10, temperature range from 25°C to 65°C and stability of encapsulation also have been studied for different amount of added polymer. Morphological characterization has been done by using SEM. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=atrazine" title="atrazine">atrazine</a>, <a href="https://publications.waset.org/abstracts/search?q=nanoformulation" title=" nanoformulation"> nanoformulation</a>, <a href="https://publications.waset.org/abstracts/search?q=nanopesticide" title=" nanopesticide"> nanopesticide</a>, <a href="https://publications.waset.org/abstracts/search?q=nanotoxicology" title=" nanotoxicology"> nanotoxicology</a> </p> <a href="https://publications.waset.org/abstracts/85148/nano-pesticides-recent-emerging-tool-for-sustainable-agricultural-practices" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/85148.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">256</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">429</span> Formulation and Evaluation of Piroxicam Hydrotropic Starch Gel</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mohammed%20Ghazwani">Mohammed Ghazwani</a>, <a href="https://publications.waset.org/abstracts/search?q=Shyma%20Ali%20Alshahrani"> Shyma Ali Alshahrani</a>, <a href="https://publications.waset.org/abstracts/search?q=Zahra%20Abdu%20Yousef"> Zahra Abdu Yousef</a>, <a href="https://publications.waset.org/abstracts/search?q=Taif%20Torki%20Asiri"> Taif Torki Asiri</a>, <a href="https://publications.waset.org/abstracts/search?q=Ghofran%20Abdur%20Rahman"> Ghofran Abdur Rahman</a>, <a href="https://publications.waset.org/abstracts/search?q=Asma%20Ali%20Alshahrani"> Asma Ali Alshahrani</a>, <a href="https://publications.waset.org/abstracts/search?q=Umme%20Hani"> Umme Hani</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background and introduction: Piroxicam is a nonsteroidal anti-inflammatory drug characterized by low solubility-high permeability used to reduce pain, swelling, and joint stiffness from arthritis. Hydrotropes are a class of compounds that normally increase the aqueous solubility of insoluble solutes. Aim: The objective of the present research study was to formulate and optimize Piroxicam hydrotropic starch gel using sodium salicylate, sodium benzoate as hydrotropic salts, and potato starch for topical application. Materials and methods: The prepared Piroxicam hydrotropic starch gel was characterized for various physicochemical parameters like drug content estimation, pH, tube extrudability, and spreadability; all the prepared formulations were subjected to in-vitro diffusion studies for six hours in 100 ml phosphate buffer (pH 7.4) and determined gel strength. Results: All formulations were found to be white opaque in appearance and have good homogeneity. The pH of formulations was found to be between 6.9-7.9. Drug content ranged from 96.8%-99.4.5%. Spreadability plays an important role in patient compliance and helps in the uniform application of gel to the skin as gels should spread easily; F4 showed a spreadability of 2.4cm highest among all other formulations. In in vitro diffusion studies, extrudability and gel strength were good with F4 in comparison with other formulations; hence F4 was selected as the optimized formulation. Conclusion: Isolated potato starch was successfully employed to prepare the gel. Hydrotropic salt sodium salicylate increased the solubility of Piroxicam and resulted in a stable gel, whereas the gel prepared using sodium benzoate changed its color after one week of preparation from white to light yellowish. Hydrotropic potato starch gel proposed a suitable vehicle for the topical delivery of Piroxicam. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Piroxicam" title="Piroxicam">Piroxicam</a>, <a href="https://publications.waset.org/abstracts/search?q=potato%20starch" title=" potato starch"> potato starch</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrotropic%20salts" title=" hydrotropic salts"> hydrotropic salts</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrotropic%20starch%20gel" title=" hydrotropic starch gel"> hydrotropic starch gel</a> </p> <a href="https://publications.waset.org/abstracts/157199/formulation-and-evaluation-of-piroxicam-hydrotropic-starch-gel" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/157199.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">145</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">428</span> Formulation of the N-Acylethanolamine, Linoleoylethanolamide into Cubosomes for Delivery across the Blood-Brain Barrier</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Younus%20Mohammad">Younus Mohammad</a>, <a href="https://publications.waset.org/abstracts/search?q=Anita%20B.%20Fallah"> Anita B. Fallah</a>, <a href="https://publications.waset.org/abstracts/search?q=Ben%20J.%20Boyd"> Ben J. Boyd</a>, <a href="https://publications.waset.org/abstracts/search?q=Shakila%20B.%20Rizwan"> Shakila B. Rizwan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> N-acylethanolamines (NAEs) are endogenous lipids, which have neuromodulatory properties. NAEs have shown neuroprotective properties in various neurodegenerative diseases including Alzheimer's disease, Parkinson's disease and ischemic stroke. However, NAEs are eliminated rapidly in vivo by enzymatic hydrolysis. We propose to encapsulate NAEs in liquid crystalline nanoparticles (cubosomes) to increase their biological half-life and explore their therapeutic potential. Recently, we have reported the co-formulation and nanostructural characterization of cubosomes containing the NAE, oleoylethanolamide and a synthetic cubosome forming lipid phytantriol. Here, we report on the formulation of cubosomes with the NAE, linoleoylethanolamide (LEA) as the core cubosome forming lipid. LEA-cubosomes were formulated in the presence of three different steric stabilisers: two brain targeting ligands, Tween 80 and Pluronic P188 and a control, Pluronic F127. Size, morphology and internal structure of formulations were characterized by dynamic light scattering (DLS), cryogenic transmission electron microscopy (Cryo–TEM) and small angle X–ray scattering (SAXS), respectively. Chemical stability of LEA in formulations was investigated using high-performance liquid chromatography (HPLC). Cytotoxicity of formulations towards human cerebral microvascular endothelial cell line (hCMEC/D3) was also investigated using an MTT (3-[4, 5- dimethylthiazol-2-yl]-2, 5-diphenyl tetrazolium bromide) assay. All cubosome formulations had mean particle size of less than 250 nm and were uniformly distributed with polydispersity indices less than 0.2. Cubosomes produced had a bicontinuous cubic internal structure with an Im3m space group but different lattice parameters, indicating the different modes of interaction between the stabilisers and LEA. LEA in formulations was found to be chemically stable. At concentrations of up to 20 µg/mL LEA in the presence of all the stabilisers, greater than 80% cell viability was observed. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=blood-brain%20barrier" title="blood-brain barrier">blood-brain barrier</a>, <a href="https://publications.waset.org/abstracts/search?q=cubosomes" title=" cubosomes"> cubosomes</a>, <a href="https://publications.waset.org/abstracts/search?q=linoleoyl%20ethanolamide" title=" linoleoyl ethanolamide"> linoleoyl ethanolamide</a>, <a href="https://publications.waset.org/abstracts/search?q=N-acylethanolamines%20%28NAEs%29" title=" N-acylethanolamines (NAEs)"> N-acylethanolamines (NAEs)</a> </p> <a href="https://publications.waset.org/abstracts/76072/formulation-of-the-n-acylethanolamine-linoleoylethanolamide-into-cubosomes-for-delivery-across-the-blood-brain-barrier" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/76072.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">203</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">427</span> Insecticidal Activity of Piper aduncum Fruit and Tephrosia vogelii Leaf Mixed Formulations against Cabbage Pest Plutella xylostella (L.) (Lepidoptera: Plutellidae) </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Eka%20Candra%20Lina">Eka Candra Lina</a>, <a href="https://publications.waset.org/abstracts/search?q=Indah%20Widhianingrum"> Indah Widhianingrum</a>, <a href="https://publications.waset.org/abstracts/search?q=Mita%20Eka%20Putri"> Mita Eka Putri</a>, <a href="https://publications.waset.org/abstracts/search?q=Nur%20Afni%20Evalia"> Nur Afni Evalia</a>, <a href="https://publications.waset.org/abstracts/search?q=Muhammad%20Makky"> Muhammad Makky</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The emulsifiable concentrate (EC) and wettable powder (WP) of Piper aduncum and Tephrosia vogelii mixed formulations were tested for their activities in the laboratory and their effectiveness in the field against cabbage pest Plutella xyostella. Cabbage leaves soaked in six different mixed formulation concentrations were tested to 2ⁿᵈ instar larvae of P. xylostella with six replications. The observation was conducted everyday until larvae reached 4ᵗʰ instar stage. Correlation between concentration and larvae mortality was analyzed using probit (POLO-PC). The survived larvae was observed by looking at the growth and development, as well as the antifeedant effects. Field efficacy test was based on LC₉₅ value from laboratory test result. The experiment used a randomized block design with 5 treatments and 3 replications to test the populations of P. xylostella larvae and insecticide effectivity. The results showed that the EC and WP mixed formulations showed insecticidal activity against P. xylostella larvae, with LC₉₅ value of 0.35% and 0.37%, respectively. The highest antifeedant effect on EC mixed formulation was 85.01% and WP mixed formulation was 86.23%. Both mixed formulations also slowed the development of larvae when compared with control. Field effication result showed that applications of EC mixed formulation were able to restrain the population of P. xylostella, with effectivity value of 71.06%. Insecticide effectivity value of EC mixed formulation was higher than WP mixed formulation and Bacillus thuringiensis formulation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=botanical%20insecticide" title="botanical insecticide">botanical insecticide</a>, <a href="https://publications.waset.org/abstracts/search?q=efficacy" title=" efficacy"> efficacy</a>, <a href="https://publications.waset.org/abstracts/search?q=emulsifiable%20concentrate%20%28EC%29" title=" emulsifiable concentrate (EC)"> emulsifiable concentrate (EC)</a>, <a href="https://publications.waset.org/abstracts/search?q=Plutella%20xylostella" title=" Plutella xylostella"> Plutella xylostella</a>, <a href="https://publications.waset.org/abstracts/search?q=wettable%20powder%20%28WP%29" title=" wettable powder (WP)"> wettable powder (WP)</a> </p> <a href="https://publications.waset.org/abstracts/86856/insecticidal-activity-of-piper-aduncum-fruit-and-tephrosia-vogelii-leaf-mixed-formulations-against-cabbage-pest-plutella-xylostella-l-lepidoptera-plutellidae" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/86856.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">242</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">426</span> Exploring the Application of Additive Manufacturing in the Production of Aerogels for the Purpose of Creating Environmentally Friendly Agricultural Formulations with Controlled Release Properties</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Pram%20Abhayawardhana">Pram Abhayawardhana</a>, <a href="https://publications.waset.org/abstracts/search?q=Ali%20Reza%20Nazmi"> Ali Reza Nazmi</a>, <a href="https://publications.waset.org/abstracts/search?q=Hossein%20Najaf%20Zadeh"> Hossein Najaf Zadeh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This study examines the use of additive manufacturing (AM) to develop sustainable and intelligent agricultural formulations that can gradually release fertilisers. AM offers the ability to design customised formulations with precise geometries and controlled release properties while taking into account their mechanical, chemical, and environmental properties. The study specifically investigates the use of an aerogel matrix mixed with a potential fertiliser in agriculture. Highly porous 3D printed aerogel structures were designed to enable the slow release of fertilisers. The performance of the formulated mixture is evaluated against other commonly used materials for slow-release applications. The findings suggest that the 3D printed gel made has great potential for slow-release fertilisers, providing an environmentally friendly solution for agricultural practices. The combination of AM technology and sustainable materials can play a vital role in mitigating the negative environmental impact of traditional fertilisers, as well as improving the efficiency and sustainability of agricultural production. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=3D%20printing" title="3D printing">3D printing</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrogel" title=" hydrogel"> hydrogel</a>, <a href="https://publications.waset.org/abstracts/search?q=aerogel" title=" aerogel"> aerogel</a>, <a href="https://publications.waset.org/abstracts/search?q=fertiliser" title=" fertiliser"> fertiliser</a>, <a href="https://publications.waset.org/abstracts/search?q=agriculture" title=" agriculture"> agriculture</a> </p> <a href="https://publications.waset.org/abstracts/163659/exploring-the-application-of-additive-manufacturing-in-the-production-of-aerogels-for-the-purpose-of-creating-environmentally-friendly-agricultural-formulations-with-controlled-release-properties" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/163659.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">94</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">425</span> Formulation Design and Optimization of Orodispersible Tablets of Diphenhydramine Hydrochloride Having Adequate Mechanical Strength</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jiwan%20P.%20Lavande">Jiwan P. Lavande</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20V.%20Chandewar"> A. V. Chandewar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In the present study, orodispersible tablets of diphenhydramine hydrochloride were prepared using croscarmellose sodium, crospovidone and camphor, menthol (as subliming agents) in different ratios and ODTs prepared with superdisintegrants were compared with ODTs prepared with camphor and menthol (subliming agents) for the following evaluation of in vitro disintegration time, dispersion time, wetting time, hardness and water absorption ratio. Results revealed that the tablets of all formulations have acceptable physical parameters. The drug and excipients compatibility study was evaluated using FTIR technique and has not detected any incompatibility. The in vitro release of drug from DC6 formulation was quick when compared to other formulations. Stability study was carried out as per ICH guidelines for three months and results revealed that upon storage disintegration time of tablets had not shown any significant difference. Microscopic study of different formulations of sublimed tablets showed formation of pores for the tablets prepared by sublimation method. Thus, conclusion can be made that the stable orodispersible tablets of diphenhydramine hydrochloride can be developed for the rapid release of diphenhydramine hydrochloride. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=orodispersible%20tablet" title="orodispersible tablet">orodispersible tablet</a>, <a href="https://publications.waset.org/abstracts/search?q=subliming%20agent" title=" subliming agent"> subliming agent</a>, <a href="https://publications.waset.org/abstracts/search?q=super%20disintegrants" title=" super disintegrants"> super disintegrants</a>, <a href="https://publications.waset.org/abstracts/search?q=diphenhydramine%20hydrochloride" title=" diphenhydramine hydrochloride"> diphenhydramine hydrochloride</a> </p> <a href="https://publications.waset.org/abstracts/4238/formulation-design-and-optimization-of-orodispersible-tablets-of-diphenhydramine-hydrochloride-having-adequate-mechanical-strength" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/4238.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">235</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">424</span> Baricitinib Lipid-based Nanosystems as a Topical Alternative for Atopic Dermatitis Treatment</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=N.%20Garr%C3%B3s">N. Garrós</a>, <a href="https://publications.waset.org/abstracts/search?q=P.%20Bustos"> P. Bustos</a>, <a href="https://publications.waset.org/abstracts/search?q=N.%20Beirampour"> N. Beirampour</a>, <a href="https://publications.waset.org/abstracts/search?q=R.%20Mohammadi"> R. Mohammadi</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Mallandrich"> M. Mallandrich</a>, <a href="https://publications.waset.org/abstracts/search?q=A.C.%20Calpena"> A.C. Calpena</a>, <a href="https://publications.waset.org/abstracts/search?q=H.%20Colom">H. Colom</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Atopic dermatitis (AD) is a persistent skin condition characterized by chronic inflammation caused by an autoimmune response. It is a prevalent clinical issue that requires continual treatment to enhance the patient's quality of life. Systemic therapy often involves the use of glucocorticoids or immunosuppressants to manage symptoms. Our objective was to create and assess topical liposomal formulations containing Baricitinib (BNB), a reversible inhibitor of Janus-associated kinase (JAK), which is involved in various immune responses. These formulations were intended to address flare-ups and improve treatment outcomes for AD. We created three distinct liposomal formulations by combining different amounts of 1-palmitoyl-2-oleoyl-glycero-3-phosphocholine (POPC), cholesterol (CHOL), and ceramide (CER): (i) pure POPC, (ii) POPC mixed with CHOL (at a ratio of 8:2, mol/mol), and (iii) POPC mixed with CHOL and CER (at a ratio of 3.6:2.4:4.0 mol/mol/mol). We conducted various tests to determine the formulations' skin tolerance, irritancy capacity, and their ability to cause erythema and edema on altered skin. We also assessed the transepidermal water loss (TEWL) and skin hydration of rabbits to evaluate the efficacy of the formulations. Histological analysis, the HET-CAM test, and the modified Draize test were all used in the evaluation process. The histological analysis revealed that liposome POPC and POPC:CHOL avoided any damage to the tissues structures. The HET-CAM test showed no irritation effect caused by any of the three liposomes, and the modified Draize test showed a good Draize score for erythema and edema. Liposome POPC effectively counteracted the impact of xylol on the skin, and no erythema or edema was observed during the study. TEWL values were constant for all the liposomes with similar values to the negative control (within the range 8 - 15 g/h·m2, which means a healthy value for rabbits), whereas the positive control showed a significant increase. The skin hydration values were constant and followed the trend of the negative control, while the positive control showed a steady increase during the tolerance study. In conclusion, the developed formulations containing BNB exhibited no harmful or irritating effects, they did not demonstrate any irritant potential in the HET-CAM test and liposomes POPC and POPC:CHOL did not cause any structural alteration according to the histological analysis. These positive findings suggest that additional research is necessary to evaluate the efficacy of these liposomal formulations in animal models of the disease, including mutant animals. Furthermore, before proceeding to clinical trials, biochemical investigations should be conducted to better understand the mechanisms of action involved in these formulations. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=baricitinib" title="baricitinib">baricitinib</a>, <a href="https://publications.waset.org/abstracts/search?q=HET-CAM%20test" title=" HET-CAM test"> HET-CAM test</a>, <a href="https://publications.waset.org/abstracts/search?q=histological%20study" title=" histological study"> histological study</a>, <a href="https://publications.waset.org/abstracts/search?q=JAK%20inhibitor" title=" JAK inhibitor"> JAK inhibitor</a>, <a href="https://publications.waset.org/abstracts/search?q=liposomes" title=" liposomes"> liposomes</a>, <a href="https://publications.waset.org/abstracts/search?q=modified%20draize%20test" title=" modified draize test"> modified draize test</a> </p> <a href="https://publications.waset.org/abstracts/166385/baricitinib-lipid-based-nanosystems-as-a-topical-alternative-for-atopic-dermatitis-treatment" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/166385.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">92</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">423</span> Formulation, Preparation, and Evaluation of Coated Desloratadine Oral Disintegrating Tablets</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mohamed%20A.%20Etman">Mohamed A. Etman</a>, <a href="https://publications.waset.org/abstracts/search?q=Mona%20G.%20Abd-Elnasser"> Mona G. Abd-Elnasser</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohamed%20A.%20Shams-Eldin"> Mohamed A. Shams-Eldin</a>, <a href="https://publications.waset.org/abstracts/search?q=Aly%20H.%20Nada"> Aly H. Nada</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Orally disintegrating tablets (ODTs) are gaining importance as new drug delivery systems and emerged as one of the popular and widely accepted dosage forms, especially for the pediatric and geriatric patients. Their advantages such as administration without water, anywhere, anytime lead to their suitability to geriatric and pediatric patients. They are also suitable for the mentally ill, the bed-ridden and patients who do not have easy access to water. The benefits, in terms of patient compliance, rapid onset of action, increased bioavailability, and good stability make these tablets popular as a dosage form of choice in the current market. These dosage forms dissolve or disintegrate in the oral cavity within a matter of seconds without the need of water or chewing. Desloratadine is a tricyclic antihistaminic, which has a selective and peripheral H1-antagonist action. It is an antagonist at histamine H1 receptors, and an antagonist at all subtypes of the muscarinic acetylcholine receptor. Desloratadine is the major metabolite of loratadine. Twelve different placebos ODT were prepared (F1-F12) using different functional excipients. They were evaluated for their compressibility, hardness and disintegration time. All formulations were non sticky except four formulations; namely (F8, F9, F10, F11). All formulations were compressible with the exception of (F2). Variable disintegration times were found ranging between 20 and 120 seconds. It was found that (F12) showed the least disintegration time (20 secs) without showing any sticking which could be due to the use of high percentage of superdisintegrants. Desloratadine showed bitter taste when formulated as ODT without any treatment. Therefore, different techniques were tried in order to mask its bitter taste. Using Eudragit EPO resulted in complete masking of the bitter taste of the drug and increased the acceptability to volunteers. The compressible non sticky formulations (F1, F3, F4, F5, F6, F7 and F12) were subjected to further evaluation tests after addition of coated desloratadine, including weight uniformity, wetting time, and friability testing.. Fairly good weight uniformity values were observed in all the tested formulations. F12 exhibiting the shortest wetting time (14.7 seconds) and consequently the lowest (20 seconds) disintegration time. Dissolution profile showed that 100% desloratadine release was attained after only 2.5 minutes from the prepared ODT (F12) with dissolution efficiency of 95%. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Desloratadine" title="Desloratadine">Desloratadine</a>, <a href="https://publications.waset.org/abstracts/search?q=orally%20disintegrating%20tablets%20%28ODTs%29" title=" orally disintegrating tablets (ODTs)"> orally disintegrating tablets (ODTs)</a>, <a href="https://publications.waset.org/abstracts/search?q=formulations" title=" formulations"> formulations</a>, <a href="https://publications.waset.org/abstracts/search?q=taste%20masking" title=" taste masking "> taste masking </a> </p> <a href="https://publications.waset.org/abstracts/10491/formulation-preparation-and-evaluation-of-coated-desloratadine-oral-disintegrating-tablets" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/10491.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">454</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">422</span> Stability and Rheology of Sodium Diclofenac-Loaded and Unloaded Palm Kernel Oil Esters Nanoemulsion Systems</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Malahat%20Rezaee">Malahat Rezaee</a>, <a href="https://publications.waset.org/abstracts/search?q=Mahiran%20Basri"> Mahiran Basri</a>, <a href="https://publications.waset.org/abstracts/search?q=Raja%20Noor%20Zaliha%20Raja%20Abdul%20Rahman"> Raja Noor Zaliha Raja Abdul Rahman</a>, <a href="https://publications.waset.org/abstracts/search?q=Abu%20Bakar%20Salleh"> Abu Bakar Salleh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Sodium diclofenac is one of the most commonly used drugs of nonsteroidal anti-inflammatory drugs (NSAIDs). It is especially effective in the controlling the severe conditions of inflammation and pain, musculoskeletal disorders, arthritis, and dysmenorrhea. Formulation as nanoemulsions is one of the nanoscience approaches that have been progressively considered in pharmaceutical science for transdermal delivery of drug. Nanoemulsions are a type of emulsion with particle sizes ranging from 20 nm to 200 nm. An emulsion is formed by the dispersion of one liquid, usually the oil phase in another immiscible liquid, water phase that is stabilized using surfactant. Palm kernel oil esters (PKOEs), in comparison to other oils; contain higher amounts of shorter chain esters, which suitable to be applied in micro and nanoemulsion systems as a carrier for actives, with excellent wetting behavior without the oily feeling. This research was aimed to study the effect of O/S ratio on stability and rheological behavior of sodium diclofenac loaded and unloaded palm kernel oil esters nanoemulsion systems. The effect of different O/S ratio of 0.25, 0.50, 0.75, 1.00 and 1.25 on stability of the drug-loaded and unloaded nanoemulsion formulations was evaluated by centrifugation, freeze-thaw cycle and storage stability tests. Lecithin and cremophor EL were used as surfactant. The stability of the prepared nanoemulsion formulations was assessed based on the change in zeta potential and droplet size as a function of time. Instability mechanisms including coalescence and Ostwald ripening for the nanoemulsion system were discussed. In comparison between drug-loaded and unloaded nanoemulsion formulations, drug-loaded formulations represented smaller particle size and higher stability. In addition, the O/S ratio of 0.5 was found to be the best ratio of oil and surfactant for production of a nanoemulsion with the highest stability. The effect of O/S ratio on rheological properties of drug-loaded and unloaded nanoemulsion systems was studied by plotting the flow curves of shear stress (τ) and viscosity (η) as a function of shear rate (γ). The data were fitted to the Power Law model. The results showed that all nanoemulsion formulations exhibited non-Newtonian flow behaviour by displaying shear thinning behaviour. Viscosity and yield stress were also evaluated. The nanoemulsion formulation with the O/S ratio of 0.5 represented higher viscosity and K values. In addition, the sodium diclofenac loaded formulations had more viscosity and higher yield stress than drug-unloaded formulations. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=nanoemulsions" title="nanoemulsions">nanoemulsions</a>, <a href="https://publications.waset.org/abstracts/search?q=palm%20kernel%20oil%20esters" title=" palm kernel oil esters"> palm kernel oil esters</a>, <a href="https://publications.waset.org/abstracts/search?q=sodium%20diclofenac" title=" sodium diclofenac"> sodium diclofenac</a>, <a href="https://publications.waset.org/abstracts/search?q=rheoligy" title=" rheoligy"> rheoligy</a>, <a href="https://publications.waset.org/abstracts/search?q=stability" title=" stability"> stability</a> </p> <a href="https://publications.waset.org/abstracts/37675/stability-and-rheology-of-sodium-diclofenac-loaded-and-unloaded-palm-kernel-oil-esters-nanoemulsion-systems" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/37675.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">423</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">421</span> Study on Preparation and Storage of Jam Incorporating Carrots (Dacus Carrota), Banana (Musa Acuminata) and Lime (Citrus Aurantifola)</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=K.%20Premakumar">K. Premakumar</a>, <a href="https://publications.waset.org/abstracts/search?q=D.%20S.%20Rushani"> D. S. Rushani</a>, <a href="https://publications.waset.org/abstracts/search?q=H.%20N.%20Hettiarachchi"> H. N. Hettiarachchi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The production and consumption of preserved foods have gained much importance due to globalization, and they provide a health benefit apart from the basic nutritional functions. Therefore, a study was conducted to develop a jam incorporating carrot, banana, and lime. Considering the findings of several preliminary studies, five formulations of the jam were prepared by blending different percentages of carrot and banana including control (where the only carrot was added). The freshly prepared formulations were subjected to physicochemical and sensory analysis.Physico-Chemical parameters such as pH, TSS, titrable acidity, ascorbic acid content, total sugar and non-reducing sugar and organoleptic qualities such as colour, aroma, taste, spread ability and overall acceptability and microbial analysis (total plate count) were analyzed after formulations. Physico-Chemical Analysis of the freshly prepared Carrot –Banana Blend jam showed increasing trend in titrable acidity (from 0.8 to 0.96, as % of citric acid), TSS (from 70.05 to 67.5 0Brix), ascorbic acid content (from 0.83 to 11.465 mg/100ml), reducing sugar (from 15.64 to 20.553%) with increase in carrot pulp from 50 to 100%. pH, total sugar, and non-reducing sugar were also reduced when carrot concentration is increased. Five points hedonic scale was used to evaluate the organoleptic characters. According to Duncan's Multiple Range Test, the mean scores for all the assessed sensory characters varied significantly (p<0.05) in the freshly made carrot-banana blend jam formulations. Based on the physicochemical and sensory analysis, the most preferred carrot: banana combinations of 50:50, 100:0 and 80:20 (T1, T2, and T5) were selected for storage studies.The formulations were stored at 300 °C room temperature and 70-75% of RH for 12 weeks. The physicochemical characteristics were measured at two weeks interval during storage. The decreasing trends in pH and ascorbic acid and an increasing trend in TSS, titrable acidity, total sugar, reducing sugar and non-reducing sugar were noted with advancement of storage periods of 12 weeks. The results of the chemical analysis showed that there were significance differences (p<0.05) between the tested formulations. Sensory evaluation was done for carrot –banana blends jam after a period of 12 weeks through a panel of 16 semi-trained panelists. The sensory analysis showed that there were significant differences (p<0.05) for organoleptic characters between carrot-banana blend jam formulations. The highest overall acceptability was observed in formulation with 80% carrot and 20% banana pulp. Microbiological Analysis was carried out on the day of preparation, 1 month, 2 months and 3 months after preparation. No bacterial growth was observed in the freshly made carrot -banana blend jam. There were no counts of yeast and moulds and coliforms in all treatments after the heat treatments and during the storage period. Only the bacterial counts (Total Plate Counts) were observed after three months of storage below the critical level, and all formulations were microbiologically safe for consumption. Based on the results of physio-chemical characteristics, sensory attributes, and microbial test, the carrot –banana blend jam with 80% carrot and 20% banana (T2) was selected as best formulation and could be stored up to 12 weeks without any significant changes in the quality characteristics. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=formulations" title="formulations">formulations</a>, <a href="https://publications.waset.org/abstracts/search?q=physicochemical%20parameters" title=" physicochemical parameters"> physicochemical parameters</a>, <a href="https://publications.waset.org/abstracts/search?q=microbiological%20analysis" title=" microbiological analysis"> microbiological analysis</a>, <a href="https://publications.waset.org/abstracts/search?q=sensory%20evaluation" title=" sensory evaluation"> sensory evaluation</a> </p> <a href="https://publications.waset.org/abstracts/59580/study-on-preparation-and-storage-of-jam-incorporating-carrots-dacus-carrota-banana-musa-acuminata-and-lime-citrus-aurantifola" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/59580.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">203</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">420</span> Effect Of Tephrosia purpurea (Family: Fabaceae) Formulations On Oviposition By The Pulse Beetle Callosobruchus chinensis Linn.</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Priyanka%20Jain">Priyanka Jain</a>, <a href="https://publications.waset.org/abstracts/search?q=Meera%20Srivastava"> Meera Srivastava</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Among important insect pests of stored grains, the pulse beetle Callosobruchus chinensis Linn. (Coleoptera: Bruchidae) is one such pest causing considerable damage to stored pulses. An effort was made to screen plant Tephrosia purpurea (Family: Fabaceae) for its efficacy against the said pest. The pulse beetle C. chinensis was raised on green gram Vigna radiata in incubators maintained at 28 ± 2°C and 70% RH. Different formulations using plant parts (root, stem, leaf and fruit) were employed in the form of aqueous suspension, aqueous extract and ether extract and the treatments were made using different dose concentrations, namely 1%, 2.5%, 5% and 10%, besides normal and control. Specific number of adult insects were released in muslin cloth covered beakers containing weighed green gram grains and treated with different dose concentrations (w/v). Observations for the number of eggs laid by the pest insect C. chinensis was recorded after three days of treatment and it was observed that in general all the treatments of the plant resulted in significant decrease in the eggs laid (no/pair) by the insect, suggesting that the selected plant has a potential to be used against C. chinensis. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Callosobruchus%20chinensis" title="Callosobruchus chinensis">Callosobruchus chinensis</a>, <a href="https://publications.waset.org/abstracts/search?q=egg%20laying" title=" egg laying"> egg laying</a>, <a href="https://publications.waset.org/abstracts/search?q=Tephrosia%20purpurea" title=" Tephrosia purpurea"> Tephrosia purpurea</a>, <a href="https://publications.waset.org/abstracts/search?q=Fabaceae" title=" Fabaceae"> Fabaceae</a>, <a href="https://publications.waset.org/abstracts/search?q=plant%20formulations" title=" plant formulations"> plant formulations</a> </p> <a href="https://publications.waset.org/abstracts/8746/effect-of-tephrosia-purpurea-family-fabaceae-formulations-on-oviposition-by-the-pulse-beetle-callosobruchus-chinensis-linn" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/8746.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">340</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">419</span> Insecticidal Effects of Plant Extract-Based Formulations on the Cotton Bollworm, Helicoverpa armigera (Hübner) (Lepidoptera: Noctuidae)</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Reza%20Sadeghi">Reza Sadeghi</a>, <a href="https://publications.waset.org/abstracts/search?q=Maryam%20Nazarahari"> Maryam Nazarahari</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Considering the effectiveness of botanical pesticides in pest management, these compounds have garnered attention as a sustainable approach to reducing pest-induced damage in agriculture while preserving the environment. Botanical pesticides enable farmers to cultivate higher-quality crops by minimizing the use of chemical pesticides. In this study, plant extracts obtained using n-hexane as a solvent from two botanical sources, thyme and eucalyptus, were evaluated under laboratory conditions for their effectiveness in controlling the cotton bollworm (Helicoverpa armigera). The mortality rate of bollworm larvae was assessed across various concentrations of the hexane-based formulations. The results revealed that the hexane-based formulations of thyme and eucalyptus extracts significantly reduced the population of bollworm larvae after 24 hours of exposure. Thyme extract, in particular, demonstrated high effectiveness as a botanical pesticide, suggesting its potential as an efficient alternative to chemical pesticides in pest management. These findings underscore that botanical pesticides can mitigate the environmental consequences of chemical pesticides and provide innovative solutions for sustainable agriculture by leveraging the active compounds present in plant extracts. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cotton%20bollworm" title="cotton bollworm">cotton bollworm</a>, <a href="https://publications.waset.org/abstracts/search?q=thyme" title=" thyme"> thyme</a>, <a href="https://publications.waset.org/abstracts/search?q=eucalyptus" title=" eucalyptus"> eucalyptus</a>, <a href="https://publications.waset.org/abstracts/search?q=extract%20formulation" title=" extract formulation"> extract formulation</a>, <a href="https://publications.waset.org/abstracts/search?q=" title=" "> </a>, <a href="https://publications.waset.org/abstracts/search?q=toxicity" title=" toxicity"> toxicity</a> </p> <a href="https://publications.waset.org/abstracts/195201/insecticidal-effects-of-plant-extract-based-formulations-on-the-cotton-bollworm-helicoverpa-armigera-hubner-lepidoptera-noctuidae" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/195201.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">4</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">418</span> On the End-of-Life Inventory Problem</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hans%20Frenk">Hans Frenk</a>, <a href="https://publications.waset.org/abstracts/search?q=Sonya%20Javadi"> Sonya Javadi</a>, <a href="https://publications.waset.org/abstracts/search?q=Semih%20Onur%20Sezer"> Semih Onur Sezer</a> </p> <p class="card-text"><strong>Abstract:</strong></p> We consider the so-called end of life inventory problem for the supplier of a product in its final phase of the service life cycle. This phase starts when the production of the items stops and continues until the warranty of the last sold item expires. At the beginning of this phase, the supplier places a final order for spare parts to serve customers coming with defective items. At any time during the final phase, the supplier may also decide to switch to an alternative and more cost-effective policy. This alternative policy may be in the form of replacing a defective item with a substitutable product or offering discounts / rebates on new generation products. In this setup, the objective is to find a final order quantity and also a switching time which will minimize the total expected discounted cost. We study this problem under a general cost structure in a continuous-time framework where arrivals of defective items are given by a non-homogeneous Poisson process. We consider four formulations which differ by the nature of the switching time. These formulations are studied in detail and properties of the objective function are derived in each case. Using these properties, we provide exact algorithms for efficient numerical implementations. Numerical examples are provided illustrating the application of these algorithms. In these examples, we also compare the costs associated with these different formulations. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=End-of-life%20inventory%20control" title="End-of-life inventory control">End-of-life inventory control</a>, <a href="https://publications.waset.org/abstracts/search?q=martingales" title=" martingales"> martingales</a>, <a href="https://publications.waset.org/abstracts/search?q=optimization" title=" optimization"> optimization</a>, <a href="https://publications.waset.org/abstracts/search?q=service%20parts" title=" service parts"> service parts</a> </p> <a href="https://publications.waset.org/abstracts/71462/on-the-end-of-life-inventory-problem" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/71462.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">335</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">417</span> Improving the Dimensional Stability of Medium-Density Fiberboard with Bio-Based Additives</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Reza%20Hosseinpourpia">Reza Hosseinpourpia</a>, <a href="https://publications.waset.org/abstracts/search?q=Stergios%20Adamopoulos"> Stergios Adamopoulos</a>, <a href="https://publications.waset.org/abstracts/search?q=Carsten%20Mai"> Carsten Mai</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Medium density fiberboard (MDF) is a common category of wood-based panels that are widely used in the furniture industry. Fine lignocellulosic fibres are combined with a synthetic resin, mostly urea formaldehyde (UF), and joined together under heat and pressure to form panels. Like solid wood, MDF is a hygroscopic material; therefore, its moisture content depends on the surrounding relative humidity and temperature. In addition, UF is a hydrophilic resin and susceptible to hydrolysis under certain conditions of elevated temperatures and humidity, which cause dimensional instability of the panels. The latter directly affect the performance of final products such as furniture, when they are used in situations of high relative humidity. Existing water-repellent formulations, such as paraffin, present limitations related to their non-renewable nature, cost and highest allowed added amount. Therefore, the aim of the present study was to test the suitability of renewable water repellents as alternative chemicals for enhancing the dimensional stability of MDF panels. A small amount of tall oil based formulations were used as water-repellent agents in the manufacturing of laboratory scale MDF. The effects on dimensional stability, internal bond strength and formaldehyde release of MDF were tested. The results indicated a good potential of tall oil as a bio-based substance of water repellent formulations for improving the dimensional stability of MDF. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=dimensional%20stability" title="dimensional stability">dimensional stability</a>, <a href="https://publications.waset.org/abstracts/search?q=medium%20density%20fiberboard" title=" medium density fiberboard"> medium density fiberboard</a>, <a href="https://publications.waset.org/abstracts/search?q=tall%20oil" title=" tall oil"> tall oil</a>, <a href="https://publications.waset.org/abstracts/search?q=urea%20formaldehyde" title=" urea formaldehyde"> urea formaldehyde</a> </p> <a href="https://publications.waset.org/abstracts/58107/improving-the-dimensional-stability-of-medium-density-fiberboard-with-bio-based-additives" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/58107.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">240</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">416</span> Development and Characterization of Novel Topical Formulation Containing Niacinamide</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sevdenur%20Onger">Sevdenur Onger</a>, <a href="https://publications.waset.org/abstracts/search?q=Ali%20Asram%20Sagiroglu"> Ali Asram Sagiroglu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Hyperpigmentation is a cosmetically unappealing skin problem caused by an overabundance of melanin in the skin. Its pathophysiology is caused by melanocytes being exposed to paracrine melanogenic stimuli, which can upregulate melanogenesis-related enzymes (such as tyrosinase) and cause melanosome formation. Tyrosinase is linked to the development of melanosomes biochemically, and it is the main target of hyperpigmentation treatment. therefore, decreasing tyrosinase activity to reduce melanosomes has become the main target of hyperpigmentation treatment. Niacinamide (NA) is a natural chemical found in a variety of plants that is used as a skin-whitening ingredient in cosmetic formulations. NA decreases melanogenesis in the skin by inhibiting melanosome transfer from melanocytes to covering keratinocytes. Furthermore, NA protects the skin from reactive oxygen species and acts as a main barrier with the skin, reducing moisture loss by increasing ceramide and fatty acid synthesis. However, it is very difficult for hydrophilic compounds such as NA to penetrate deep into the skin. Furthermore, because of the nicotinic acid in NA, it is an irritant. As a result, we've concentrated on strategies to increase NA skin permeability while avoiding its irritating impacts. Since nanotechnology can affect drug penetration behavior by controlling the release and increasing the period of permanence on the skin, it can be a useful technique in the development of whitening formulations. Liposomes have become increasingly popular in the cosmetics industry in recent years due to benefits such as their lack of toxicity, high penetration ability in living skin layers, ability to increase skin moisture by forming a thin layer on the skin surface, and suitability for large-scale production. Therefore, liposomes containing NA were developed for this study. Different formulations were prepared by varying the amount of phospholipid and cholesterol and examined in terms of particle sizes, polydispersity index (PDI) and pH values. The pH values of the produced formulations were determined to be suitable with the pH value of the skin. Particle sizes were determined to be smaller than 250 nm and the particles were found to be of homogeneous size in the formulation (pdi<0.30). Despite the important advantages of liposomal systems, they have low viscosity and stability for topical use. For these reasons, in this study, liposomal cream formulations have been prepared for easy topical application of liposomal systems. As a result, liposomal cream formulations containing NA have been successfully prepared and characterized. Following the in-vitro release and ex-vivo diffusion studies to be conducted in the continuation of the study, it is planned to test the formulation that gives the most appropriate result on the volunteers after obtaining the approval of the ethics committee. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=delivery%20systems" title="delivery systems">delivery systems</a>, <a href="https://publications.waset.org/abstracts/search?q=hyperpigmentation" title=" hyperpigmentation"> hyperpigmentation</a>, <a href="https://publications.waset.org/abstracts/search?q=liposome" title=" liposome"> liposome</a>, <a href="https://publications.waset.org/abstracts/search?q=niacinamide" title=" niacinamide"> niacinamide</a> </p> <a href="https://publications.waset.org/abstracts/146181/development-and-characterization-of-novel-topical-formulation-containing-niacinamide" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/146181.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">112</span> </span> </div> </div> <ul class="pagination"> <li class="page-item disabled"><span class="page-link">&lsaquo;</span></li> <li class="page-item active"><span class="page-link">1</span></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=formulations&page=2">2</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=formulations&page=3">3</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=formulations&page=4">4</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=formulations&page=5">5</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=formulations&page=6">6</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=formulations&page=7">7</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=formulations&page=8">8</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=formulations&page=9">9</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=formulations&page=10">10</a></li> <li class="page-item disabled"><span class="page-link">...</span></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=formulations&page=14">14</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=formulations&page=15">15</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=formulations&page=2" rel="next">&rsaquo;</a></li> </ul> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th foundational anniversary</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Account <li><a href="https://waset.org/profile">My Account</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Explore <li><a href="https://waset.org/disciplines">Disciplines</a></li> <li><a href="https://waset.org/conferences">Conferences</a></li> <li><a href="https://waset.org/conference-programs">Conference Program</a></li> <li><a href="https://waset.org/committees">Committees</a></li> <li><a href="https://publications.waset.org">Publications</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Research <li><a href="https://publications.waset.org/abstracts">Abstracts</a></li> <li><a href="https://publications.waset.org">Periodicals</a></li> <li><a href="https://publications.waset.org/archive">Archive</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Open Science <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Philosophy.pdf">Open Science Philosophy</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Award.pdf">Open Science Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Society-Open-Science-and-Open-Innovation.pdf">Open Innovation</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Postdoctoral-Fellowship-Award.pdf">Postdoctoral Fellowship Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Scholarly-Research-Review.pdf">Scholarly Research Review</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Support <li><a href="https://waset.org/page/support">Support</a></li> <li><a href="https://waset.org/profile/messages/create">Contact Us</a></li> <li><a href="https://waset.org/profile/messages/create">Report Abuse</a></li> </ul> </div> </div> </div> </div> </div> <div class="container text-center"> <hr style="margin-top:0;margin-bottom:.3rem;"> <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank" class="text-muted small">Creative Commons Attribution 4.0 International License</a> <div id="copy" class="mt-2">© 2024 World Academy of Science, Engineering and Technology</div> </div> </footer> <a href="javascript:" id="return-to-top"><i class="fas fa-arrow-up"></i></a> <div class="modal" id="modal-template"> <div class="modal-dialog"> <div class="modal-content"> <div class="row m-0 mt-1"> <div class="col-md-12"> <button type="button" class="close" data-dismiss="modal" aria-label="Close"><span aria-hidden="true">×</span></button> </div> </div> <div class="modal-body"></div> </div> </div> </div> <script src="https://cdn.waset.org/static/plugins/jquery-3.3.1.min.js"></script> <script src="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/js/bootstrap.bundle.min.js"></script> <script src="https://cdn.waset.org/static/js/site.js?v=150220211556"></script> <script> jQuery(document).ready(function() { /*jQuery.get("https://publications.waset.org/xhr/user-menu", function (response) { jQuery('#mainNavMenu').append(response); });*/ jQuery.get({ url: "https://publications.waset.org/xhr/user-menu", cache: false }).then(function(response){ jQuery('#mainNavMenu').append(response); }); }); </script> </body> </html>